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1969 34: 100-110
ABSTRACTS
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ABSTRACTS
Baldini,
Mario
Klaus
Betke,
Arthur
M.D.,
Munich,
T. E. Brittingham,
Jacques
M.D.,
Caen,
M.D.,
Paris,
Pietro
deNicola,
Ludvik
Donner,
Tenn.
France
Green,
M.D.,
M.D.,
New
F. W.
Gunz,
Susan
R. Holl#{225}n,
M.D.,
Harry
S. Jacob,
Miehel
M.D.,
M.D.,
Cohn
Georges
Math#{233},M.D.,
Italy
Thomas
F. Necheles,
Czechoslovakia
Japan
Bracha Ramot, M.D.,
Peter C. Reizenstein,
City
Zoran
New
York
York
Sydney,
M.D.,
Jamra,
India
Tokyo,
M.D.,
Goldstein,
City
Budapest,
OF
AND
FOETAL
Minnesota
John
J#{243}zwik, A. Jasiewicz,
J. Diakowski.
From
General
Chemistry,
Bialystok,
174,
Poland.
S. Sack,
Steiner,
E.
Ralph
Brazil
IN
THE
M.
of
of Medicine,
Haematologia
2:171-
1968.
hydrolysates
purified
columns
and
using
the
of erythrocyte
stroma
Dowex-50
ion-exchange
effluent
was examined
for
the amount
of glucosamine
mine.
In adult
erythrocyte
amino
amounts
samples.
tosamine
S.
R.
and galactosastroma
both
sugars
were
detected
in greater
than
in the corresponding
foetal
The ratio of glueosamine
to galacwas
similar
in both
materials.H.
HEMOGLOBIN
FUNCTION
IN
STORED
oxygen
Ohio
France
Boston,
Aviv,
M.D.,
Mass.
Israel
Stockholm,
Belgrade,
M.D.,
Buenos
New
M.D.,
Aires,
York
J. Clin.
dissociation
Argentina
City
Providence,
Chicago,
M.D.,
Sweden
Yugoslavia
Ph.D.,
M.D.,
Denmark
N.Y.
R.I.
Illinois
San
Francisco,
Invest.
48:311-
of
blood
stored
in various
preservatives
was studied
over a
period
of several
weeks.
A marked
increase
in oxygen
affinity
was noted
within
the first
week in blood
stored
in either
standard
ACD
solution
or ACD
solution
to which
adenine
had been added.
This increase
in
correlated
levels
of erythrocyte
acid.
When
affinity
red
much
cell
less
that erythroeyte
the oxygen
out that this
may
when
must
well
with
3-dephosphoglyceric
falling
inosine
was added
to the prethere was much
less change
in 02
during
the first two weeks
of storage
servative,
and
2,
levels
of
2,
3
DPG
also
fell
rapidly.
The
authors
conclude
2, 3 DPG
is important
in
dissociation
of blood.
They point
change
in
oxygen
dissociation
be of some
therapeutic
significance
massive
transfusions
of stored
blood
be administered.-T.
F. N.
BLOOD.
H. Franklin-Bunn,
M. H. May,
W.
F.
Kocholaty,
C. E.
Shields.
From
U.S.
Army
Medical
Research
Laboratory,
Fort
100
Tel
Wallerstein,
#{176}2 affinity
The
were
Columbus,
M.D.,
Ultmann,
0.
The
Smos
Danuta
Kilczewska,
the Department
School
U.S.S.R.
M.D.,
Knox, Kentucky.
321, 1969.
ERYTHROCYTES.
Switzerland
Parfs,
M.D.,
B. Schorr,
Manfred
Hungary
COMPONENT
ADULT
Berne,
Moscow,
M.D.,
Rolovi6,
Julian
Minneapolis,
S#{227}o
Paulo,
Macpherson,
Edgardo
Australia
ERYTHROCYTES
HsxossmiE
M.D.,
M.D.,
Netherlands
Pavia,
Prague,
Fukutake,
Robert
Ira
M.D.,
M.D.,
Huser,
Kassirsky,
Sven-Age
Killmann,
M.D.,
Copenhagen,
Frederick
A. Klipstein,
M.D., Rochester,
Maria
Kope#{233},
M.D.,
Warsaw,
Poland
S. Africa
Nashville,
J. B. Chatterjea,
M.D., Calcutta,
F. J. Cleton,
M.D., Leiden,
The
Katsuhiro
Joseph
M.D.,
T. H. Bothwell,
Editor
Hans-Jurg
Germany
Cardiff, Wales
M.D., Johannesburg,
Bloom,
M.D.,
INFLUENCE
ON
AND
OF
HEMOGLOBIN
ERYTHROCYTE
BETA
BLOOD,
PRECIPITATION
METABOLISM
THALASSEMIA.
VoL.
IN
D.
34, No. 1
G.
(JULY),
ALPHA
Nathan,
1969
Calif.
From www.bloodjournal.org by guest on October 15, 2014. For personal use only.
101
ABSTRACTS
to lead
T. B. Stossel,
R. B. Gunn,
H. S. Zarkowand M. T. Laforet.
From
Children’s
Hospital
Medical
Center,
Boston,
Mass.
J. Clin. Invest. 48:33-41,
1969.
to loss of hemoglobin
represents
scribed.-T.
sky,
the
twelfth
F. N.
DIFFERENCES
Red
and
cells from patients
with Hb H disease
/3-thalassemia
major
were
separated
“young”
and “old”
cell layers
by dif-
into
ferential
centrifugation.
In
content,
hexose
tivity,
and
monophosphate
potassium
conclude
that
globin
shunt
led
flux
inclusion
precipitation)
the
ac-
authors
to
( hemo-
formation
is
related
to
cation
permeability.
The
increase
in potassium
flux does
not appear
to
be correlated
with the level of intracellular
GSH. The authors
are of the opinion,
however,
that the premature
removal
of incluerythrocytes
related
is
the
to
the
inclusions
changes
mechanical
rather
in
in
than
thalassemia
properties
of
secondary
to
permeability.-T.
cation
HUMAN
BETWEEN
a-
AND
any
F.
search
Unit,
Biochemistry,
Med.
normal
gotes.
N.
of
suggest
that
if
genes,
RiVERDALE-BRONX
STABLE
THE
HEMOGLOBIN
:
UN-
AN
RESULTING
SUBSTITUTION
OF
ARGININE
GLY-
would
FOR
B6 OF THE
f3 POLYPEPT1DE
CHAIN.
H. M. Ranney,
A. S. Jacobs,
L. Udem,
R. Zalusky.
From
Dept.
of Medicine,
Albert
Einstein
College of Medicine,
Bronx,
N. Y. Biochem.
Biophys.
Res.
Commun.
33:1004-1011,
1968.
CINE
AT
HELICAL
Another
previously
hemoglobin
from
presented
hemolytic
bin
was
a
with
anemia.
accounted
for
On
vertical
globin.
unrecognized
variant
hemolysate
who
RESIDUE
identified
in
German-Jewish
30
per
cent
starch
of
gel
the
at
semic
within
8.6
( TEB bufFer),
it had
a mobility
similar
to
that
of Hb S. Fingerprint
analysis
of Hb
RB revealed
a substitution
of arginine
for
the normally
occurring
glycine
at residue
24
of the
of
a
beta
chain
(B6).
This
substitution
interior
for a nonpolar
residue
in the
of the molecule
might
be expected
to alter
the relationship
to
attached
polar
the
heme-globin
heme.
relationship
of the peptide
Such
changes
have
been
of
Liverpool,
220:664-668,
chain
in
found
than
/3
the
processes
termination
/3-thalassemia.
debate
the
discovery
two
types
IN
but
of
of
a-
of
chains
University
of
of
be
to
thalasidentical
error.
translation
seemed
(Lon-
and
to
experimental
Although
not
excluded,
Liver-
experiments
normal
shown
mRNA
thus
of
Nature
pulse-labelling
was
limits
/3-THALASSE-
Weatherall,
S.
From Depart-
England.
1968.
kinetics
of
num-
comment:
for
by
de-
a varying
Abstracter’s
Medicine,
means
varia-
thalassemia
Clegg,
D. I.
and P. Wad.
assembly
genes
considerable
SYNTHESIS
J. B.
pool,
By
may
chain
B.
ment
the
hemo-
L.
a-chains
genes
a
forward
more
ex-
a-chain
In a bet-
four
of
supported
Na-Nakorn
the
pH
put
the
be
of
in
of
a-chain
genes.
HEMOGLOBIN
woman
a partially
compensated
The abnormal
hemoglo-
inheritance
chains-A.
don)
these
the
upon
with
might
pairs
of
be
MIA.
of
often
authors
sequence.
explain
is
The
pairs
two
severity
affected
persons
unstable
variant.
resulting
one
theory
is
with
patients
phenomenon
Two
also
of
in
has
only
in
This
hemoglobin
found
abnormal.
ben
of
Brit.
1968.
necessarily
erozygote
FROM
England.
amino-acid
pending
hEMOGLOBIN
a-CHAIN
Department
this
not
would
THE
University
man
different
tion
AND
Pos-
Cambridge,
/3-chain
plained
be
OF
mutant
that
corresponding
of
a-CHAIN
is a quantitative
difference
in the
of a- and a-chain
variants
to
hemoglobin
in respective
heterozyIn the case of a-chain
variants
the
half
about
AND
f3-THALASSEMIA.
J. 4:748-750,
There
de-
HEMOGLOBIN
DUPLICATION
From
proportion
This
H. Lehmann
and R. W. Carrell.
M.R.C.
Abnormal
Haemoglobin
Re-
percentage
increased
erythrocyte
sion-containing
OF
GENE.
the “young”
cells contain
inclusion
bodies
(precipitated
alpha
chains)
whereas
in Hb
H disease
it is the older
cells
which
contain
the intracellular
precipitates
( f3 chains).
Comparison
of the
number
of inclusioncontaining
cells and glycolysis,
glutathione
stability.
hemoglobin
a-
BETWEEN
MUTANTS
SIBLE
fl-thalassemia,
such
and
be
normal
The
chain
in
defective
chain
initiation
was
abnormal
ribosomal
assembly
was
not
thought
to be an
explanation
for the defective
chain
synthesis
in this disease.
The results
suggest
that in
/3-thalassemia
reduced
/3-chain
synthesis
is due
to defective
regulation
and
hence
reduced
production
of
normal
mRNA.A. L. B.
From www.bloodjournal.org by guest on October 15, 2014. For personal use only.
102
A
ABSTRACTS
H DISsE
IN
G. Efremov,
I. Nedelkovski,
H. Duma,
S. Apostolova,
M. Andrejeva
and
T. Stoj/evski.
From
the School
of
Medicine,
University
of Skopje,
Yugoslavia.
Blood
Transfusion
Bull.
23:79-84,
1968.
CASE
OF
HEMOGLOBIN
FAILURE
year old
long lasting
A
with
to
hemoglobin
have
displayed
for
H
thalassemia.
of
the
be
propositus
and
were
her
mild
was
two
not
were
within
HYDROPS
but
in
“BSB
FETALIS
one
and
fetalis
R.
values.-Z.
study
weeks
gestation.
4.9
Gm.
per
bilirubin
sion
All
were
The
cent
was
bodies
some
were
beyond
the
infants.
alive,
and
hour.
In
morphologic
gosity
that
blood
these
that
this
was
hydrops
cent
hundred
sociated
27
present
it
is
in
in
did
a majority
not
Thailand
Bart’s
born
effect
ineffective
severity
of
sickle
KERNICTERUS
W.
of
IN
DEHYDROGENASE
IN
H.
W.
SINGAPORE.
Boon.
Colorado
Colorado.
the
From
Medical
Center,
Pediatrics
R.
Uni-
Den-
41:1055-1062,
ular,
and
Malay
more
neonatal
in
the
absence
of
bin
upon
to
values
of
of
kernicterus
clothing
or
which
developed
addition
to
to
some
appeared
especially
be
ethnic
fam-
predisposed
jaundice.
the
recently
at
Ten
per
cent
of
in this series either
In
were
biliru-
levels
transfusion,
neonatal
is
predis-
serum
occur.
infants
kernicterus.
who
in
group
reach
there
When
mild,
ethnic
frequently
exchange
signs
even
deficiency.
however
the
a
more
than
hyperbilirubinemia,
kernicterus
may
enzyme-deficient
required
to
and
infants,
G-6-PD
process,
superimposed
Singpartic-
infants
severe
Caucasian
hemolytic
position
in
hyperbilirubinemia,
Singapore-born
any
in
infants
Indian
and
have
prolonged
in a significant
infants
Chinese
extent,
do
is found
ictenic
Apparently
lesser
present
and
with
hemoglobin-I.
one
NEONATAL
infants
stored
In
two
had
in
been
moth
in
in
G.
E.
University
the
of
City,
to
instances
dressed
balls.-
S.
tive
DEFICITS.
Miller
Birth
Kansas
significant
and
Defects
E.
F.
Center,
Medical
Center,
J. Dis.
Amer.
differences
motor
hearing
children
PRODUCTION
Child.
1968.
examination,
as-
B.
Kansas.
116:37-43,
No
J.
From
Kansas
IN
NEUROLOGICAL
Holmes,
of
10.9
B.
LoNG-Tuur
Smith.
three
hydrops
BILmuBINEMIA
OF
of
believe
northern
is
was
1968.
for
fetalis.
population,
a dosage
apparent
AND
and
ver,
assumed
predisposing
the
Penn1968.
heterozywas
evidence
is
L.
Univer-
J. B. S.
parents,
factor
In
the
using
or
INFANTS
Brown
versity
severe
much
a significant
infants
with
the
homozygous
authors
thalassemia
of
of
the
and
present
the
heterozygous
per
gene
were
was
mothers,
of
DEFICIENT
ilies
Inclu-
survived
Although
iron-deficiency
cent.
11
and
B. S.
differences,
blood
erythrocytes
suggesting
smears,
alpha-thalassemia.
to
Only
38
was
cord
per
most
infants
the
mean
none
a thalassemia
peripheral
described
28 and
in a few
evidence
for
cent
hemoglobin
the
1 mg.
noted
is
per
infants
mean
below
an
100
between
and
were
of
born
27
born
of
73:265-266,
frequency
crises-I.
apore.
BART’S
Thailand
almost
decreasing
CELL
II
Philadelphia,
Pediat.
G-6-PD
deficiency
number
of severely
WITH
Northern
with
hemoglobin.
Bart’s
in this
of
in
associated
J.
Call,
Hospital
Pennsylvania,
PREVENT
SICKLE
Hb
IN
NORTHERN
THAILAND.
B.
Thumasathit,
A. Nondasuta,
S. Silpisornkosol, B. Lousuebsakul,
P. Unchalipongse
and M. Mangkornkanok.
From
the Faculty of Medicine,
Chiang
Mai University,
Chiang
Mai,
Thailand.
J. Pediat.
73:132138,
1968.
Hydrops
of
L.
GLUCOSE-6-PHOSPHATE
and
No evi-
HEMOGLOBIN
usually
the
F.
HYPERBILIRUBINEMIA
sibling
inclusions”
ASSOCIATED
From
TO
IN
on the
presence
was found.
noted.
Hb A2
normal
Lessen.
cell
typical
test,
alive
children
Oski,
in
patient
made
inclusion”
micro-poikilocytosis
of Hb
H was
dence
F
“BSB
F.
sity
HCL
EPISODES
ANEMIA.
sylvania.
rapidly
migrating
Hb H ( 7%) and
Hb A2 (0,3%).
Hb F was found
2,3%. In the pedigree,
parents
of the
decreased
to
Diagnosis
the
This
features
PROMAZINE
PAINFUL
In a double
blind
study,
similar
to the one used
with
in Ghana,
promazine
HC1
born woman
demonstrated
disease.
hematological
basis
of
Macedonian
anemia
was
42
OF
THE
MACEDONIA.
were
43
to
in
development,
observed
7li
years
neurologic
or
in
a group
old
who
percepof
63
had
From www.bloodjournal.org by guest on October 15, 2014. For personal use only.
103
ABSTRACTS
neonatal
jaundice
bilirubin
levels
with
between
ml. when
they were
of their
peers
who
had
-J.
B. S.
BARBITURATE
Y.
ing
or potentiating
W. C.
CYCLE
KREBS
C.
Catz
Pediat.
YOUNG
and
Children’s
S. I.
Normal
Hospital,
Res.
and
studied.
2:361-370,
The
of barbital
UDP-glucuronyl
in
liver
adult
enzyme
transferase
homogenates
mice
activity
from
and rabbits.
was
greatest
animals,
and
or phenobarbital
the
effect
The
in
in
effect
on
the newyoung
ani-
mals appeared
to be dose-related.
UDPGT
activity
was also observed
Increased
in newborn
mice
following
treatment
of dams
during late pregnancy.
In newborn
and young
rabbits,
barbiturate-pretreatment
accelerated
bilirubin
clearance
from
the
serum.
In
treated
adult
rabbits
there
was
an increase
in bile flow and in total bilirubin
excretion.
From these observations
it is suggested
that
barbiturates
not only increase
hepatic
UDPGT activity,
but may also augment
cell or
membrane
permeability,
and/or
facilitate
bilirubin
transport
through
the liver, particularly
in adult
animals-I.
B. S.
OF
THE
IN
LmnuMIc
COLONY
NORMAL
SERUM.
E. R. Stanley,
W.
A.
Robinson
and G. L. Ada.
From
Walter
and Eliza Hall Institute,
Royal Melbourne
Hospital,
Melbourne,
Australia.
Aust.
J.
Exp.
Biol. Med.
Sci. 46:715,
1968.
cytes.
Only
sera
contained
dehydrogenase,
dehydrogenase.
In
leu-
succinate
dehydrogenase
was
A clear
survey
of the literature
and
of the problem
is given in the introduction.
The obtained
results
are discussed
also on the basis of previous
personal
investigations.-P.
d. N.
lower
than
in
OF
ENZYMES
AND
normal
LEUKOCYTES.
F. Martelli
M.
Clinica
cells.
GLYCOGENOLYSIS
LEUKEMIC
and
Medica,
M.
IN
Haematologica
The
following
NORMAL
F. Grignani,
Tonato.
From
the
University
Italy.
of
Perugia,
53:89-118,
enzymes
1968.
were
studied:
amylo-1,6-glucosidase,
phos-
Phosphoglucomutase
very
high
was
found.
kemia
activity.
In
the
than
in
subject
substance.
substances
in-
exhibited
a
glucose-6-phosphatase
acute
normal
are
and
myelogenous
activities
cells.
A
available
is critically
in
few
the
analyzed-P.
leu-
were
higher
data
on
literature,
this
which
d. N.
Ponassi,
and C.
KINETICS
IN
THE
Doc.
A.
P. Boccaccio,
L. Morra,
F. Brema
Sacchctti.
From
the Istituto
Sci-
entifico
di
of
Italy.
and
ligation
given
Interna,
University
Haematologica
53:269-
1968.
Normal
tial
Medicina
Genova,
284,
ics.
No
enzymatic
to
mouse
condehy-
kemic
leukocytes
( acute
and myelogenous
leukemias
) the levels of enzymatic
activities
were more elevated
than in normal
granulo-
be
Some
oxydase,
alpha-ketoglutarate
malate
GRANULOCYTE
leukopoietic
taken
isocytric
succinate
Normal
and
leukemic
mouse
serum
contains
a factor
capable
of stimulating
suspensions
of mouse
marrow
cells
to form
colonies.
This
has
been
characterized
as
heat labile,
nondialysable,
migrating
in the
a-globulin-post-albumen
region,
resistant
to
ether,
RNA-ase
and DNA-ase,
with buoyant
density
of about
1.34 and a sedimentation
coefficient
of
between
4.5 and
7.0.
It is
probably
a protein
or glycoprotein
and may
specifically
were
were
pyruvate
P-enzyme,
phorylase.
STIMULATING
AND
MOUSE
a
leukocytes
phoglucomutase,
glucose-6-phosphatase
and
maltase.
The lowest
activity
was found
in
amylo-1,6-glucosidase,
followed
by
phos-
LEUKOCYTES
FACTOR
LEU-
Haematologica
enzymes
:
phorphorylase,
PROPERTIES
Italy.
aconitase,
dehydrogenase,
fumarase,
newborn
HUMAN
leukemic
enzyme,
drogenase,
ac-
stimulat-
M. F. Martelli
and F.
Clinica
Medica,
Uni-
following
consideration
densing
injection
colony
IN CIRCULATING
M. Tonato,
From
the
Grignani.
versity
of Perugia,
53:1-20, 1968.
BILIRUBIN
IN
the
factor-F.
into
Prior
born
EXCRETION
the
N.
jaundiced.
OF
ANIMALS.
From
enhanced
and
been
hibiting
KOCYTES.
AND
ADULT
Yaffe.
Buffalo,
1968.
tivity
not
ENHANCEMENT
CONJUGATION
AND
unconjugated
serum
6 and 23mg./l00
compared
to a group
DFP32
study
Tagged
splenomegalic
of the
some
splenic
tagged
aspects
granulocytes
(through
vein)
granulocytes
of
par-
dogs
in
granulocyte
were
studied
were
order
kinet-
also
From www.bloodjournal.org by guest on October 15, 2014. For personal use only.
ABSTRACTS
104
in the splenic
artery
and vein as well as in
some
splenectomized
dogs.
The values
obtinned
were
similar
to those
observed
in
humans.
The total granulocyte
pool and the
granulocyte
turnover
rate were higher
in the
dog.
The
marginal
granulocyte
pool
was
reduced
after
splenectomy,
two values
autotransfusions
were
was
that
shown
amount
of
through
it.
perimental
of
the
granulocytes
circulating
investigations
regard
were carried
rate technics,
tion on the
CASES
AND
OF
AN
The
problem
purposes
: to
of
ment
of
the
ascertain
of
the
The
were
different
of
one
of
ploidy
Denver
the
chromosomes.
in
for
of the
in
cation,
while
all
the
the
absence
authors,
of
of
to
mosomes.
be
frequent-P.
while
In
the
is
further
the
CsmoMosoiIE
STUDIES
C,
frequently
found
those
of the
N.
ON
in
show
skin
that
PATIENTS
Second
C.
WITH
and
R. P.
Clinic
University
Debrecen,
the
W.
G. Nagy
the
for
Medical
Hungary.
2:179-186,
Haematol-
1968.
myelofibrosis
polycythemia
developing
vera.
of
the
No
As
after
compared
second
group
for
majority
the
chromosome
radiation
damage
tients.-S.
R.
to
the
nor-
logical
of
found
was
metaphase
suggesting
among
the
pa-
A
RE-
H.
IN
AMPHIBIA:
Balls and L. N. Ruben.
of East Anglia,
School
Sciences,
Exp.
aneuploidy
aberration
was
TUMORS
M.
University
il-
E,
Norwich,
Tumor
Lymphoid
F
or
by
to
Res.
From
of Bio-
England.
10:238-260,
propor-
G group
are
to
These
tumors
to
their
and
in
Progr.
1968.
are
of
tumors
discussed
been
adults
to
seem
been
pear
in
attempted.
Some
to be caused
by
appear
um-associated
related
to
reference
features.
of
Four
to be
readily
the
fifteen
all
transfer
has
of these
tumors
apa viral agent;
others
a bacterium
agent-I.
induction
found
which
re-
species.
with
biological
species
been
etiology,
have
amphibian
date
amphibian
their
transferable
less
to
six
transferability,
some
the
have
originate
chro-
as extrachromo-
A group
tumors
ported
of
appearance
metaphasic
of the
From
secondary
case
D,
inversely
the
not
Chromosome
studies
have
been
performed
on 9 patients
with
polycythemia
vera in exacerbation
and in 3 patients
with
one
According
is
of
to
VERA.
LYMPHOID
represented
of
but
the
dividing
not inherited.-F.
Medicine,
VIEW.
third
extrachromosomes
frequency
of
classifi-
the
were
in
cent
evidence
and
were
Denver
groups
length
d.
This
leukesame
the
A girl with acute
leukehad had CC did not show
blood
cells or fibroblasts.
Ph’ is acquired
metaphasic
was
in
Chromosomes
more
somes,
aneu-
chromosomes.
the
the
that
toward
evolution
and
extrachromosomes
tional
suggested
a scheme.
second
of
of
relapse,
cells.
literature.
distribution
the
various
the
Med.
chromosome
in
demonstrated
other
abnormalities
abnormalities
presence
the
in
groups
the
G. The
and
to
clonal
case
abnormalities
by
of
chromosomic
present
had
length
each
cases
Ph’
blood
cells while
fibroblast
cultures.
mia whose
father
the Ph’ in either
patient
under
each
factors
Ann.
mal picture,
no chromosome
aberration
was
found
in the first
group
of patients.
In one
develop-
the
system
The
lustrated
ap-
cases
of the
among
predisposing
was
the
per
ogia
groups
from
reported
the
the
three
Carson,
From
of Tas-
granulocytic
had had
50
School,
ex-
chronologic
in the
Aust.
in
Yurgutis.
two
particular
aneuploidy.
those
of
with
involved
The
statistical
analysis
of extrachromosomes
groups
and
Internal
extrachromosomes,
whether
are
from
showed
marrow
Haematolog-
occurrence
various
Liu-
FAMILIAL
Australia.
with
chronic
whose
mother
disease
LEU-
investigated
establish
the
examination
and
Italy.
IN
1969.
man
(CG)
A
mia
THREE
1968.
chromosomes
Hobart,
18:7,
G. Rovera
and
Clinica
Medica,
the
Tonino,
was
pearance
mania,
PAT-
IN
STAGE.
From
trachromosomes
to
and
and accuinforma-P.
d. N.
MYELOGENOUS
ACUTE
of
53:465-480,
D.
of
POLYCYTHEMIA
Pegoraro.
ica
pre-
DISTRIBUTION
CHRONIC
IN
ex-
not
EXTRACHROMOSOMES
University
and
had
consideration
out with dependable
thus giving
important
problems
concerned.
OF
KEMIA
of
which
EVOLUTION
TERNS
granulocytes
it
held up a large
into
A. S.
Dept.
of
the
taken
STUDIES
A. C. Baikie,
0. M.
Spiers
and I. Ferguson.
Medicine,
University
KAEMIAS.
other
means
These
been
CLONAL
the
By
tagged
spleen
conditions
viously
L.
while
unchanged.
CYTOCENETIC
E.
or
U.
a bacteri-
From www.bloodjournal.org by guest on October 15, 2014. For personal use only.
105
ABSTRACTS
COMPARATIVE
Sruny
PRODUCTION
HEALTHY
E
L. Gergely,
OF
Gy.
Gy.
SUBJECTS.
F. D. Toth
and
From
the Institute
of MicroUniversity
Medical
School
of
Hungary.
Acta Microbiol.
Acad.
biology,
Debrecen,
Hung.
14:391-397,
LETS.
S. van Creveld
From
The
Haemophuia
(N.H.),
The Netherlands.
218:361-362,
1968.
INTERFERON
LEUKOCYTES
THE
LEUKEMIC
AND
Hadhdzy,
Szegedi.
Sci.
ON
BY
1967.
The
Leukocytes
obtained
from patients
with
myeloid
leukemia
produced
more interferon
than
those
from
leukocytes
healthy
infected
produced
virus
donors.
by
more
Leukemic
Newcastle
interferon
those
infected
by Sendai
VirUS.
Such a difference
was not demonstrable
when
normal
leukocytes
were
used.
The
average
interferon
titres
were
244 and 38 with
the Sendai
virus
and 985 and 27 with
the Newcastle
disease
virus.
Calculated
from
the average
of all experimental
results,
leukemic
leukocytes
produced
15 times
more
interferon
than
normal
ones.
Interferon
production
prostaglandin
aggregation
and
Addition
PGE2,
ma.
current
LEUKEMIA
A.
CLUSTERS.
G. Glass, J. A. Hill and R. W. Miller.
From
the Epidemiology
Branch,
National
Cancer
Institute,
National
Institutes
of
Health,
Bethesda,
Md. J. Pediat.
73:101107, 1968.
THE
of
death
certificates
of
all
chil-
dren
dying
of leukemia
or other
cancer
in
Los
Angeles
County
between
1960
and
1964,
revealed
a uniform
mortality
rate
throughout
By
the
constructing
a few
narrow
closely
to create
those
W.
Department
Gross.
cine,
University
1207,
1968.
described
believe
cases
overemphasize
buffer
absolute
of
an
the
IN
epidemiology
tends
that
of this
the
plays
virus
disease.
PLATELETS
INFLUENCE
E2
ON
OF
THE
E1
PROSTAGLANDINS
AGGREGATION
OF
BLOOD
AND
PLATE-
was
simple:
of
count
and
in
with
7.4,
volume
in
yield
the
in
aggregates
before
distribu-
the
amount
and
Lat.
plate-
the
vol-
B.
BLEEDING
AND
Corteiltire
the
Coulter
of
EXTRACORPOREAL
Al.
Haemat.
rich
times
pH
ADHESIVENESS
From
and
MediWschr.
Plasma,
5000
aggregates.-K.
UREMIA
Italy.
Schneider
Internal
determined
these
AGPARTICLE
K#{246}ln.Klin.
solution
DURING
caccio.
literature.
possibility
oncogenic
of
in
induction
of platelet
aggregaor by protamine
sulfate.
The
incorporated
TIME
to
leukemia
platelets
TimonsocYTE
diluted
A-med,
umes
concen-
and
suggest
be corrected
by
of
is
particle
curves,
lets
“gerrymandering”
of
the
spread
a role in the
-J.
B. S.
in
that
in high
ELECTEONIC
of
is
following
by CaCL,
tion
ag-
curves
similar
thrombasthe-
K#{252}bler, W.
procedure
Girling’s
around
AN
R.
tion
disag-
inhibited
abnormal
OF
BY
thrombocytes,
possible
comparable
of
COUNTER.
and
rapid
PGE1
even
DETERMINATION
PLATELET
tracts.
it was
clusters
around
infectious
cases,
leukemia
authors
boundaries
census
boundaries
grouped
previously
The
to
predetermined
however,
GREGATION
Counter
Analysis
of
concept
The
OF
the
prevented
Clanzmann’s
thrombasthenia
that the abnormality
cannot
PGE2.-A.
B.
by
increased
failed
to promote
ADP aggregation
platelets
from
a patient
with
this
The results
are consistent
with the
disease.
from patients
with myeloid
leuless inhibited
by actinomycin
D
than
that by normal
leukocytes.
Leukocytes
from patients
with lymphoid
leukemia
produced
as much
or less interferon
than those
from healthy
persons.-S.
R. H.
Addition
(PGE2)
by ADP producing
seen in Clanzmann’s
trations,
of the
leukocytes
kemia
was
SIGNIFICANCE
E2
gregation.
gregation
to those
disease
than
rapid
the
of patients
but showed
from
normally
abnormally
of
C. N. Pascha.
Clime,
Huizen
Nature
(Lond.).
a variety
with ADP
disaggregation.
platelets
aggregated
and
University
11:188-197,
DIALYSIS
and
D.
of
BranMilano,
1968.
Study
of seven cases. Platelet
adhesiveness
evaluated
by means
of a method
de-
rived
from
the
original
Wright’s
method.
A
significant
decrease
of platelet
adhesiveness
was observed
in the middle
of the dialysis
period.
At the end,
there
was a tendency
to rise, which
continued
for two hours
thereafter.
The bleeding
time presented
an opposite behavior
(first
prolonged,
then
reduced
toward
initial
values).
Abstracter’s
comment:
These
results
are similar
to those
From www.bloodjournal.org by guest on October 15, 2014. For personal use only.
106
ABSTRACTS
observed
during
extracorporeal
for cardiopulmonary
by-pass.
are of interest,
even
though
small number
of observations-P.
NECTOMY.
B. Jochweds
and B. KeydanaJedrzejewska.
From
the
Department
of
Internal
Medicine,
Institute
of Tubercu-
circulation
The
results
limited
to a
d. N.
losis,
Warsaw,
Poland.
PLATELET
COUNTS
B.
From
IN
Kong.
School
Pediat.
the
72
hours,
ranged
302,000.
In
35
1700
between
2200
veloped
20
days
of
and
69,000
less than
ROLE
OF
age.
The
were
156,000
with
birth
Gm.,
platelet
seen
in
days
in
in
whole
later.
platelet
levels,
Pauly,
operative
may
red
hesiveness
in
ACUTE
comment:
important
implies,
hemostasis
in
to
if
red
or
e.g.,
The
changes
ad-
method.
exists
platelets
merely
or plasma.
determine,
cell
this
cells
as
the
are
relevant
L.
thrombosis-A.
mechanism
by
has
the
RHAGIC
CRISES
IN
THROMBOCYTHEMIA
A
CASE
last
few
authors
J. L.
Suskind.
School,
40:847,
of transformation
of lymand
intensively
anti-
investigated
years.
In
describe
transformation
a
induced
the
similar
by
dun-
present
paper
lymphocyte
HgC12.
Studies
of action
of this
simple
chemical
should
help to explain
the mechanism
of action
of
more
complicated
stimulants-I.
C.
LYMPHOCYTE
IN
Vn-rio
CHARACTERIZATION
TOXIN.
From
vine)
W.
the
Proc.
with
It
author
of
OF
CYTOTOXICITY:
HUMAN
LYMPHO-
P. Koib
and C. A. Granger.
University
of California
(InNat. Acad. Sci. USA 61:1250,
OF
AFTER
SPLE-
of
is
The
immunoglobulin
propose
and
that
to
lymphotoxin.”
feel
a mw.
are
far
the authors
lymphocytes
leads
“human
authors
with
mediates
and dethe exact
accomplished
present
study
adenoidal
is then
assayed
with the growth
interfere
authors
this
In the
human
phytohemagglutinin-this
layers.
HErIoR-
how
production
material
to
B.
details
from clear.
stimulate
a protein
VASOMOTOR
RABBITS
phytohemagglutinin
been
the
AND
CHLORIDE.
The
lymphocyte
in some
way
tumor
immunity,
allograft
rejection
layed
hypersensitivity.
However,
fragility,
possibility
the
red
ing
MERCURIC
1968.
platelet
by
method
gens
LYMPHOCYTES
RATS
observed
a PRP-ADP
that post-
increased
measured
changes
The
phocytes
postoperative
was
changes,
to
Hellem’s
indicate
is
cell
when
Abstracter’s
that
greater
discuss
A. Caron
and R. R.
of Oregon
Medical
Oregon.
J. Cell
Biol.
University
weigh-
THE
adhesiveness
contribute
C.
OF
PIGS,
BY
Portland,
1969.
IN
authors
the sudden
release
of
the platelets
in the pathosyndrome
observed.-M.
K.
GUINEA
INDUCED
1400
infants
blood
compared
to
The
author
considered
mixture.
the
The
of
TRANSFORMATION
FROM
TO OPERATION.
A
from
of
BLAST
birth
four
de10 and
Platelet
adhesiveness
measured
in whole
blood
by
Hellem’s
glass-bead
column
method
was markedly
increased
within
four
hours
of surgery.
Adhesiveness
measured
in
blood reconstituted
from postoperative
platelet-rich plasma
( PRP) and postoperative
red
cells
was
greater
than
that
observed
in
blood
reconstituted
from post-operative
PRP
and preoperative
red cells.
A storage
artifact
was
excluded
by repeating
the experiment
three
role
5-
of a
sple-
IMMUNOHEMATOLOGY
P. N
Bennet.
From
Department
of Medicine,
University
of Aberdeen,
Aberdeen,
Scotland. J. Clin Path.
21:695-697,
1968.
rise
described.
of
urine
after
first
B. S.
RESPONSE
is
vascular
increase
acid in the
thrombocythemia
possible
counts
whose
ERYTHROCYTES
PLATELET
38:
and
the
Gm.,
between
two
Lek.
weights
during
lowest
1 Kg-I.
nectomy
genesis
Tg.
of recurrent
accompanying
hydroxyindoloacetic
patient
with
the
platelet
case
with
serotonin
120,000
Among
38
infants
was
below
1700
thrombocytopenia
weight
interesting
12-hourly
between
infants
and
An
crises
thrombocytopenot corroborated.
above
month.
ing
reported
was
first
determinations
remained
PREMATURE
J.
The previously
nia of prematurity
During
HEALTHY
Fogel,
D. Arias
and F.
the
University
of Miami
of Medicine,
Miami,
Florida.
J.
73:108-110,
1968.
INFANTS.
Pol.
1968.
1440-1441,
the
This
for its ability
to
of L cell monothat
this
material
is
of 85,000,
it is not an
not complement.
The
this material
mediates
From www.bloodjournal.org by guest on October 15, 2014. For personal use only.
107
ABSTRACTS
lymphocyte
cytotoxicity.
Abstracter’s
cornment:
There
is certainly
as yet no direct
evidence
that such
materials
are
produced
in
vivo
as
a result
of lymphocyte
contact
with antigens.-I.
C.
and
smallpox
vaccine.
phytohemagglutinin
umn
purification.
Separation
W.
ON
THE
membrane
From
Washington,
D.
UROPOD.
the
Hospital.
and
LYMPHOCYTE
McFarland.
C.
V.
Science
A.
163:818,
1969.
view
Lymphocytes
in
motion
as well
ing.
as to
the
Electron
tail
surface
on
microscopic
section
shows
microspike
sites
of
on
that
necessary
macrophage
for
intercourse
of
the
AND
ON
OF
ANTIGEN
R.
IN
that
the
are
the
D.
From
Moore
the
ern
ANTIBODY
Reserve
Nature
M.
of
Pathology,
horse
carried
out
experiments
of
antibody
macrophages
are
ulation
The
not
macrophages
may
the restimulation
E. U.
on
-J.
an
of
OF
relatives
Harris.
Dept.
From
of
Houston,
synthesis.
the
IN
RE-
PERIPHERAL
M.
Hersh
BLOOD
and
University
J.
of
Developmental
Texas.
1194,
effect
INTERACTION
E.
E.
bead
sponse
to
separated
of
macrophage
used
cells’
were
streptodornase,
purified
reduced
antigen
when
leukocyte
Culture
the
column
these
purified
monolayers
response
lymphocyte
to
streptolysin
purified
re-
compared
to
in
unvitro.
lymphocytes
generally
antigen.
0,
protein
on
restored
The
in
in
dizygotic
IgA
a
twins,
macroglobulinemia
pa-
immunodiffusion
tests
and Heremans,
quantification
of
and
of
antigens
streptokinasederivative
of
in
1gM.
( 252
1965)
serum
The
values
total
rural
author
population
IgA
of
and
donors
for
and
of
district
individuals)
blood
male
IgG
the
a
(38
the
in
a
individuals)
immunoglobins
were
levels
with
increased
age throughout
adult life, with no difference
between
the sexes.
This
relationship
with
age was not found
for 1gM, but females
showed
significantly
higher
levels
than
males.
Analysis
of variance
performed
on
results
obtained
in 89 monozygotic
and 42
dizygotic
twin
pairs,
provided
evidence
of
both
genetic
have
and
an
environmental
effect
on
23
being
population.
1gM
above
was
significantly
pected
greater
in the
than in
95
The
of
number
per
greater
cent
of
the
values
could
renorfor
tolerance
than
in
relatives
investigated.
those
im-
done
of 353
with
The
the
of
were
limit
be
ex-
by chance
alone.
Also a significantly
number
of M-components
was found
1gM class in the serum
of relatives
the general
population,
whereas
the
number
classes
studies
compared
mal
levels
a total
patients
were
influences
serum
Family
macroglobulinemia;
blastogenic
suspensions
IgG,
sample
found.
of
have
Carbonara
for the
of
determined
thoroughly
suits
Glass
Uni-
population,
and
of
munoglobins.
1968.
suspensions
were
the
radial
three
villages
Netherlands
to
Texas,
Therapeutics,
100:1184-
Immunology,
( Mancini,
were
used
similar
the
BLASTOGENIC
HUMAN
LEUKOCYTES.
levels
from
Simple
group
fact,
antibody
ANTIGEN-INDUCED
SPONSE
In
inhibitory
MACROPHAGE-LYMPHOCYTE
THE
lymphoapparently
antigen.
exert
restim-
by
lymphocytes
specific
IN
State
random
that
the
for
synthesis
LEVELS
authors
suggest
required
primed
the
recognize
9
the
which
U.
months
Ohio.
1968.
ferritin,
E.
INFLUENCES
Thesis.
of monozygotic
in
has
West-
Cleveland,
spleen
of
vitro.-J.
investigated
the
accuracy
and
reproducibility
of this method.
It was
impossible
to determine
absolute
values
and
therefore
results
were
reported
as percentages
of a pooled
reference
serum.
In a
Case
immunized
with
are
1969.
groups
levels
Schoenberg.
219:297,
rabbits
Employing
BY
LYMPHOCYTES.
D.
University,
(London)
earlier
cytes.
and
Dept.
in
Kaiff.
Immunoglobin
control
and
SYNTHESIS
OF
W.
Leyden,
versity
group
C.
Cusrwus
antigen
response
IMMUNOGLOBULIN
Al.
tients.
RESTIMULATION
blastogenic
EVIRONMENTAL
SERUM
MAN.
this
immunological
accomplished-I.
is
of
interaction
called
speculates
which
lympho-
uptake
to antigen
GENETIC
it is mov-
lymphocyte
by
or
and
cells
projections
the
the
col-
This
observation
author
areas
tail.
a
“feels”
other
which
multiple
The
microspikes.
receptor
have
contacts,
to debris,
of
macrophage-lymphocyte
lymphocytes
tail apparently
also
temporarily
attaches
to
by
macrophages
blastogenesis.
MICROSPIKES
response
unaffected
by a semipermeable
prevented
the
restoration
of
The results
are consistent
with
and
cytes
The
was
of
of
M-components
immunoglobulins
in
the
other
were
not
differ-
From www.bloodjournal.org by guest on October 15, 2014. For personal use only.
108
ABSTRACTS
ent
in
that
both
groups.
These
results
indicate
has occurred
of 1gM
cells
in families
of macroglopatients.
The
results
of these
bear
out the
technical
difficulties
in quantification
of immunoglobulin
a disregulation
producing
bulinemia
studies
involved
levels
and
provide
sound
evidence
for
the
that
at least
one
monoclonal
is in part
genetically
deter1. C.
hypothesis
gammopathy
mined-F.
EFFECTS
OF
CASEIN
ON
THE
REGENEBA-
II. This
was
to the stimulant
in group
I
between
the injection
of chiorambucil
and
the protein-free
diet.
Nevertheless,
in the
two groups
the restoration
of the neutrophil
action
apparently
of casein,
and
due
administered
lymphocyte
levels
occurred
dan-
chiefly
the
ten days
of the casein
refeeding
regimen.
This
restoration
was much
more
noticeable
in group
I, mainly
affecting
the
increase
in number
and size of the lymphocytes:
after
ten
days
there
were
9630 В± 870
ing
lymphocytes
per
cmm.
compared
to
5710
В±
640 in group
II. The cellular
index (product
of the
two
perpendicular
diameters)
in
PHOCYTES
IN
PROTEIN
DEPLETED
RATS
group
I rose from
112.5
В± 6.4 j2
on
the
INJECTED
WITH
A RDIoMIrIETIC
AGENT
first day of refeeding
to 159.4
В± 2.9 p2 on
(CHLORAMBUCIL
) . A POSSIBLE
IMMUNOthe eleventh
day,
while
in group
II the
LOGICAL
MECHANISM
FOR
THE
LYMPHOrespective
values
were
109.0
В± 3.1 z2 and
POIETIC
EFFECT
OF INGESTED
PROTEIN.
A.
124.5
В±
5 2
The
final
weight
of the
Aschkenasy.
Centre
National
de la Reand lymph
nodes
( four cervical
and
cherche
Scientifique,
Laboratoire
d’H#{233}- spleen
two
mesenteric)
were
similarly
higher
in
matologie
Nutritionnelle,
45-Orleans-la
group
I (641
В± 37 mg.
and
90 В± 9 mg.)
Source,
France.
Rev. Franc.
Etud.
Clin.
than
in group
II (506 В± 23 and 55 В± 6 mg.)
Biol. 13:792-799,
1968.
in
spite
of
identical
body
weights.
In the
An attempt
was made
to find whether
lymph
nodes
the
germinal
centers
were
the
regeneration
of leukocytes
and
espelarger
and more numerous
in group
I (6 В±
cially
the
increase
in number
and
size
of
1.7 per
section)
than
in group
II ( 1.8 В±
blood
lymphocytes
induced
by the ingestion
0.1 ). These
results
suggest
that
in group
I
of casein
in protein
deficient
rats could
be
the lymphocytes
newly
formed
after the ininterpreted
as an immunological
response
jection
of
chlorambucil
were
conditioned
of
the animal
to the “secondary”
protein
to the
casein
before
the
beginning
of the
ingestion.
In this
case,
such
a response
protein
free
diet,
and
because
of this they
should
be
more
readily
demonstrable
in
reacted
to the refeeding
of protein
with an
animals
previously
conditioned
to these proanamnestic
response.
In group
II the newly
teins
than
in unconditioned
animals.
This
formed
lymphocytes
were
formed
during
the
hypothesis
suggested
the
following
expenperiod
of
nitrogen
deprivation
and
could
TION
OF
mental
scheme:
neal
injection
male
cent
six
per
a
BLOOD
After
of
adult
casein
protein-free
rats
men
NEUTROPHILS
single
intrapenito-
( 12
chiorambucil
rats
for
diet
submitted
were
a
Lms-
AND
not,
mg/Kg.)
received
a diet of 18
two weeks
followed
by
( group
I ). Six other
only
to
the
latter
regi-
the
beginning
a week before
the injection
II ). After
a weight
loss of 40 per
on the average
in 78 days of deprivain group
I and 55 days in group
II, all
rats were
restored
for ten days
to a
diet
of
( group
cent
tion
18
per
cent
casein.
The
the
chlorambucyl
reached
its
maximum
four days after
the injection,
the
fall in lymphocyte
level being
more marked
(minimum
of В± 1000 cells/cmm.
) than that
of
the neutrophils.
There
then
followed
a
partial
two
spontaneous
groups
neutrophils
was
more
restoration
which
was more
pronounced
than
in the
lymphocytes
pronounced
in group
I than
in
in
that
lymphocytes
glandular
in
actions.
Thus,
and
seem
by
the
the
and
group
CAL
an
dietary
rence
IN
IGG-IGA.
Pegoraro.
From
of
quantitative
lymphocytes
Torino,
pro-
M.
CrroLoGI-
AND
A
rereaction
proteins.-G.
CASE
MACROGLOBULINEMIA
53:305-320,
interest
of
IMMUNOLOGICAL
University
primary
to the
changes
GLOBULIN
Case
is a known
immunological
to contribute
PATTERNS
STROM
L.
than
anamnestic
volumetric
yoked
It
increase
in number
of large
and the number
and size of
germinal
centres
are more
pro-
nounced
would
conditioned.
the
CLINICAL,
leukopenia
by
caused
be
therefore,
fact
OF
WALDEN-
WITH
CRYO-
A. Pileri, C. Ricci and
the Clinica
Medica,
Italy. Haematologica
1968.
report
of a 58 year
of the case consists
and in some cytological
old female.
The
in its rare occuraspects.
There
From www.bloodjournal.org by guest on October 15, 2014. For personal use only.
109
ABSTRACTS
was
a systemic
proliferation
and
lymphoreticular
istics in protein
electronmicroscopy
These
of lymphocytic
cells,
synthesis
whose
were
and immunofluorescence.
cells
were
different
from
those
of
lymphocytic
leukemia
because
of
greater
proliferative
activity
and
response
to phytohemagglutinin.-
chronic
their
greater
dapest,
Hungary.
178. 1968.
charactershown
by
In
the
ionic
bound
proteins
bound
IgG
in
Luus
OF
LOWED
42
200
ON
PARATIVE
N.
ERYTHEMATOSUS
ANALYSIS
HOOD.
ADULT
From
School
versity
CASES
FOL-
and
Uni-
York,
New
42:37-49,
a high
mortality
rate
in
the
patients
A
HUMAN
RARE
FINDING
IN
ISOANTIBODY.
L.
ISRAEL.
and R. Pinker-Schweitzer.
ment
of Serology,
Central
Kupat
Holim,
Haifa,
Israel.
Sci.
5:114,
Hornstein
From DepartLaboratory.
Israel J. Med.
1969.
and
Although
to
be
saline.
ous
anti-Tj’
is
as
transfusion
report
on
Israel.-B.
are
extremely
occurrence
reviewed.
rare,
a possible
accidents.
the
R.
A REPORT
ON
loG
lime
cause
This
of
Szdsz,
INFLUENCING
TO
ERYTHROCYTES.
Eva
Puskds,
J. Gergely.
From
the
Hematology
and
Blood
a single
temperature
fixation
a
more
the
be
washing
The
and
showed
stable
it
of
The
and
moglobin
The
COUNTING
AutoAnalyser
bond
is the
antiTja
has
first
in
C. A.
Central
ASPECIFIC
I. Arky,
Medgyesi,
Institute
Transfusion,
of
Bu-
Au-ro-
AN
SMA-4
and
red
less
EVALUATION
Belfast,
falsely
results.
The
blood
output
L. B.
AUTOANALYSER
Ireland.
in
and
After
red
most
showed
precision
hemoglobin
Hematocrit
J.
and
HosClin.
that
the
1969.
the
acceptable.
modifications
curate.
low
THE
evaluation
and
the
cent
erroneous,
automated
Northern
Systematic
were
23 per
were
OF
Path. 22:11-18,
of
and
T. R. J. Lappin,
A. Lamont
Nelson.
From
Royal
Victoria
C.
pita1,
counts.
cell
a conductance
the need for rapid
stained
films.-A.
of
ac-
white
by
that
increases
fIt.
gave
of he-
reliable
giving
reporting
SMA-4.
system
estimations
estimations
consider
counting
and
and
estimated
method,
was
M.C.H.C.
most of these
authors
MACHINE.
reproducible
hematocrit,
carry-over
seri-
Wrrss
EXPERIENCE
BLOOD
curate
isfactory
FACTORS
BINDING
can
A. E.
Green,
V. L. Middleton,
K. C. Prentis,
and A. C. Signy.
From St. Stephen’s
Hospital,
London,
England.
J. Clin.
Path.
22:19-27,
1969.
MATIC
conductance
SOME
IgG
of IgG
adsorption
firmly
of
MISCELLANEOUS
AN
significance
considered
by
the
surface
which
was
characteristic
of the
papain-insensitive
IgG population.
IgG fixation
is highly
influenced
by ionic
strength
and
by the cation
composition
of the mcdiurn-S.
R. H.
AntiTja
isoantibody
was
found
in the
serum
of a woman
who was examined
because
of habitual
abortions.
The same antibody
was later
also found
in the serum
of
her brother.
The history
of this antibody,
its
incidence
but
the
extent
of
FIRST
on
nonloosely
existed,
with
onset
before
15 years
of age. The authors
believe
that
combination
therapy
with
adrenocortical
steroids
and chloroquine
provide
the best prognosis
in SLE;
however,
antimetabolites
were
not
evaluated.-J.
B. S.
ANTITJa,
eliminated,
dependence
beside
with
and
1968.
Childhood
SLE in this group
of patients
was very similar
to adult
SLE.
The exceptions were a tendency
for the onset in girls
to be clustered
around
adolescence,
a twofold higher
incidence
of hepatosplenomegaly and adenopathy,
and a lower incidence
of pulmonary
involvement
among
the children,
as well as a shorter
duration
and a
higher
washings
Thereafter,
physiological
that
C0M-
Medicine,
of
N. Y. Pediatrics
Crni.D-
A. C. Meislin
the New
York
CONCURRENTLY.
Rothfield.
IN
WITH
CASES
are
2:175-
intercellular
remains
cells.
to
medium
SYSTEMIC
of 3-5
the
blood
eluted
P.d.N.
course
solutions,
red
Haematologia
cell
and
white
accuracy
cell
were
counts
determinations
samples
measurement
but
it
counts
described
certain
as
was
also
ac-
were
sat-
this
is a
influenced
by marked
variations
in
concentration
of
EDTA,
proteins
and electrolytes.
It should
be
possible
to effect
computorized
data
handling
and,
with
an analogue-digital
converter,
to produce
data compatible
with
From www.bloodjournal.org by guest on October 15, 2014. For personal use only.
110
ABSTRACTS
records.
Abstracter’s
Comment
: The
main
disadvantages
appear
to be the graphical
output
which
is not usually
compatible
with
patient
records
and the conductance
method
for measuring
hematocnit.
Errors
due to the
latter
may be difficult
to detect
in a busy
laboratory.-A.
L. B.
ous
THE
patients
Among
the incidence
in
OF
SPLENECTOMY
son,
0.
IN
Burgert,
the Mayo
J. Dis.
INFECTION
W. D. ErickH. B. Lynn.
From
CHILDREN.
Jr., and
Clinic,
FOLLOWING
Rochester,
Child.
116:1-12,
Minn.
After
reviewing
17 reported
nectomies,
involving
1313
adding
a group
of 154 cases
Clinic,
the authors
conclude
tomy
followed
below
the
by
age
increased
of
Amer.
1968.
one
series of splechildren,
and
from the Mayo
that
splenecyear
susceptibility
AMERICAN
is definitely
to
SOCIETY
Cleveland,
See
announcements,
seri-
back
a mortality
older
of infection
is not
non-splenectomized
fections
quently
meningitis.
youngsters
cent
of
than
a
35
one
per
year,
than
but inin the splenectomized
group
fretook the form
of sepsis
and/or
Among
these
splenectomized
the course
was frequently
short,
their
with
HAZARD
with
children
infection,
cent.
78
per
cent
developing
ill
became
higher
peers,
mortality.
serious
within
12
Among
the
infections
76
months,
and
per
91
30 months
of operation.
Pneumococcus,
meningococcus
and
hemophilus
influenzae
were
the most
frequent
organisms
reported,
in the order
given.
The
authors
do not appear
to favor
administraper
cent
tion
of
might
within
prophylactic
infer
from
although
antibiotics,
this
report
that
course
of penicillin
for all
dergoing
splenectomy
would
part of valor-I.
B. S.
OF
December
advertising
youngsters
be the
HEMATOLOGY
7-9
section
of this
a 30
issue
one
month
Unbetter
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