Department of Paediatrics
Annual Report 2009тАУ10
тАШтАШ
Courage is resistance
to fear, mastery of fear тАУ
not absence of fear.
тАЩтАЩ
Mark Twain
Contents
4
ChairтАЩs Report
6
Staff Highlights
13
Medical Education Training
and Scholarship in the
Department of Paediatrics
28
Division of Adolescent Medicine
36
Division of Cardiology
48
Division of
Clinical and Metabolic Genetics
56
Division of
Clinical Pharmacology & Toxicology
64
Division of
Developmental Paediatrics
70
Division of Endocrinology
80
Division of Gastroenterology,
Hepatology and Nutrition
92
Division of Haematology/Oncology
112 Division of Immunology/Allergy
118 Division of Infectious Diseases
128 Division of Neonatology
144 Division of Nephrology
150 Division of Neurology
162 Division of
Paediatric Emergency Medicine
170 Division of Paediatric Medicine
180 Division of Respiratory Medicine
190 Division of Rheumatology
200 Bloorview Kids Rehab
202 Transplant Centre
206 Paediatric Housestaff
207 Paediatric Grand Rounds
211 Promotions/Recognition
212 Awards
216 Resident and Fellow
Awards and Achievements
217 Annual Resident and
Fellow Research Day
ChairтАЩs Report
Left to right: Ms. Marilyn Monk, Dr. Rayfel Schneider, Dr. Meredith Irwin, Dr. Denis Daneman, Dr. Daune MacGregor, Mr. Ben Vozzolo
What are the metrics that matter in judging the success of a
So what did we actually do this past year? From a clinical
department such of ours? Some would say quality of the care
standpoint, I continue to be impressed by the ever-improving
provided to our patients and nothing else; others, that what
standards of care. A few examples only: the Sickle Cell Program
really counts is how we renew ourselves both by training the
saw more patients in the clinic but fewer in the Emergency
next generation of paediatricians and paediatric subspecialists
Department, and it had fewer in-patient days; the Cystic Fibrosis
and by recruiting the smartest and best faculty; and still others
Program and its adult counterpart at St. MichaelтАЩs Hospital are
would measure our success by just how far we have been able
talking about median survival rates above 40 years of age; the
to push the frontiers of new knowledge that make advances
SickKids Team Obesity Management Program is experiencing
in health care and education possible. Most of us, however,
significant success helping teens avoid bariatric surgery for a
would agree that it is the sum of all three plus more:
while at least; and the Gastrointestinal Failure Team reports
integration, innovation, inspiration, and, yes, perspiration.
similar achievements. Meanwhile, wait times in the Emergency
It is not an exaggeration to claim that our department remains
the past. The list goes on, but so do the challenges in patient
committed to all of the above and continues to impress with
safety and continuous quality improvement.
Department are down, and chemotherapy delays are a thing of
its achievements. In the exciting milieu of The Hospital for
Sick Children and University of Toronto, superbly supported
Education scholarship is thriving in our department with
by CEO Mary Jo Haddad and Dean Catharine Whiteside and
increasingly more trainees seeking scholarship as a career
their teams, it would be hard not to succeed. And letтАЩs also
path. The close interaction with the Learning Institute with its
not forget the secure funding that we receive through the
own scientists and simulation lab is well poised to support these
comprehensive Alternate Funding Plan with the Ministry of
individuals. The next challenge in teaching relates to the imminent
Health and Long-Term Care of the Province of Ontario.
opening of the Mississauga Academy of Medicine with the need
for recruitment and training of a new group of teachers.
2
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Research funding has steadily increased, leading to an
As we celebrate our successes, so we need to reflect on
associated surge in productivity in every type of research from
the challenges ahead: patient safety, quality improvement,
understanding fundamental molecular and cellular processes
outcomes analysis, access, and flow are some but not all
to developmental biology, clinical trials, health services, health
aspects of clinical excellence and deserve our increasing
economics and health policy research. Of particular note is
attention. The pendulum in research training has swung away
the incredible productivity of our Paediatric Medicine group:
from fundamental science and towards newer areas of clinical
TARget! Kids, the Paediatric Outcomes Research Team,
investigation such as health services, health policy, health
Complex Care and others.
outcomes тАУ all essential components of a robust research
enterprise. Also, we must incorporate and evaluate new
The past year was an active one in recruitment, both of
education technologies in our environment and make the
Division heads and junior faculty. The future looks very bright
best use of information technology.
with Jim Whitlock from Vanderbilt moving in to lead the
Division of Haematology/Oncology, Steve Porter from Harvard
This end-of-academic-year report offers me the opportunity to
joining us as Head of the Division of Paediatric Emergency
say a huge thank you to everyone who contributes so much to
Medicine, and Lisa Robinson stepping up to Head of
the vigour and vitality of our department. The faculty scored at
Nephrology. Add to these other new faculty such as Yaron
the very top of job and institutional engagement in the recent
Avitzur, Binita Kamath and Thom Walters in Gastroenterology,
Staff Engagement Survey, strong evidence of our departmentтАЩs
Hepatology and Nutrition, Komudi Siriwardena in Metabolics,
commitment to our patients, hospital and university.
Daniel Roth in Paediatric Medicine, Suzanne Beno in Paediatric
Emergency Medicine, and Reshma Amin in Respiratory
With my deepest gratitude to all,
Medicine. And recruitment continues. At the same time as
we welcome our new faculty, a big thank you is in order for
those Division heads stepping down after their 10 years of
outstanding leadership: Victor Blanchette in Haematology/
Oncology; Denis Geary in Nephrology and Bill Mounstephen
in Paediatric Emergency Medicine.
Denis Daneman, MB, BCh, FRCPC
Chair of Paediatrics, University of Toronto
Paediatrician-in-Chief, The Hospital for Sick Children
R.S. McLaughlin Chair in Paediatrics, at The Hospital for Sick Children
International health initiatives have expanded in the past year,
most especially our relationship with Hamad Medical Centre
in Doha, Qatar. Led medically by Denis Geary, this initiative
is by all accounts highly successful. Participation in numerous
other international activities continues, for example the Toronto
Addis Ababa Academic Collaboration, which links many
University of Toronto departments with their counterparts
at the University of Addis Ababa in Ethiopia.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
3
Staff Highlights - Welcome! New Division heads raise expectations
Stephen Porter
Division Head
Paediatric Emergency Medicine
Porter: Clear communications
PorterтАЩs CV shows an impressive list of credentials and
Service excellence and high-quality care are priorities for
achievements in clinical work and research. It also reveals
the SickKids Emergency Department. Meeting these objectives
that he earned his bachelorтАЩs degree in biology and English
is a challenge when there is high demand and the families
literature. тАЬI have a thing about words, always did,тАЭ he says.
seeking emergency care come from many different cultures,
тАЬOne of the frustrating things in medicine is how to arrive at the
with many different expectations and needs. ItтАЩs a challenge
right question and getting a reliable answer. I love to figure out
that calls for innovation.
the best way to gather and use information from parents.тАЭ
Meet the man for the job, Stephen Porter, the new Division
He did this in Boston with the 3-C (clear, concise communications)
Head of Paediatric Emergency Medicine. Recruited from
campaign that used a plain-language, single-page form which
ChildrenтАЩs Hospital Boston, he joined SickKids Sept. 1, 2010
parents were asked to complete upon arrival. The form asks
with a vision that is rooted in family-centred care and effective
them to share their worries and questions, and identify the
integration of personnel, processes and resources.
treatment they think might be needed. It is an excellent way
SickKids has one of CanadaтАЩs busiest emergency departments,
developed and tested the form at Boston, and it became a
receiving almost 58,000 patients a year. Only a fraction of
standard part of the registration process after he left. He is
those cases can be admitted to SickKids. тАЬThe front door to
eager to see if it will add value for care at SickKids.
to start a fruitful conversation with families, says Porter. He
SickKids is always open,тАЭ Porter says, тАЬbut not the backdoor
that leads from Emerg to the hospital.тАЭ
Other innovations are in the offing, for example, a way to
address the information needs of families after discharge
The job of Emergency is to sort тАЬthe worried well from the
from emergency care. Porter plans to capture familiesтАЩ email
critically illтАЭ while always being prepared for the worst, such as
addresses in registration, then communicate with them
a pandemic outbreak. Careful planning, top-notch teamwork,
electronically to best support them during their childтАЩs
good intra-hospital collaboration, and innovative use of
home-based care. The email they receive will also include
information technology are all critical, he says. And, above
a link to the health information website, aboutkidshealth.ca.
all, clarity in communications, which forms the basis of best
practice in emergency medicine.
Anyone could have thought of that but no one else did. PorterтАЩs
talent for creative solutions is exactly what SickKids needs as
it strengthens its culture of innovation.
4
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Lisa Robinson
Division Head
Nephrology
Robinson: Integrating science
Her plans include an additional nephrologist and a nurse
Lisa Robinson is a scientist and clinician with exceptional
practitioner to do in-patient work, and she wants to strengthen
communications skills and a natural inclination to look at the
big picture. She was born and raised in Toronto and earned her
medical degree at University of Toronto, followed by a paediatrics
residency at University of Western Ontario in London and a
fellowship in paediatric nephrology at Duke University in North
the fellowship program with more international partnerships.
тАЬWe have trained people from all over the world and SickKids
is a popular destination for nephrology specialists,тАЭ she says.
тАЬWhat the trainees see here in one year, they wouldnтАЩt see at
home in many years.тАЭ
Carolina where she completed her research training. She joined
SickKids in 2002.
Mentorship is important to Robinson. In 2006 she started an
outreach program called Kids Science that deploys volunteer
In April 2010 she was appointed Head of Nephrology to replace
trainees to work with students of middle- and high-school age
Denis Geary who is a leader of SickKidsтАЩ partnership with the
and inspire them to pursue a career in science or technology.
Hamad Medical Corporation in Qatar to advise on the creation
of a new, state-of-the-art childrenтАЩs hospital. The transition
тАЬKids are turned off by science, and the problem is the way we
has been smooth. тАЬDenis is very wise and I talk to him a lot,тАЭ
teach it,тАЭ Robinson says. тАЬSchools present science as a finished
Robinson says.
product but thatтАЩs the wrong idea. Scientists are constantly
This doesnтАЩt mean itтАЩs business as usual in Nephrology.
on questions that the children ask. The results are fantastic тАУ
Robinson has all kinds of ideas for improvement. She
schools tell us our kids are more likely to take science courses
recognizes the need for integration of clinical, basic, and
than those who havenтАЩt taken part in the program.тАЭ
trying to do things better. In Kids Science we base our teaching
translational research, and under her leadership one of the
staff nephrologists has started weekly rounds of integrated
Kids Science was supported by the Ontario Ministry of Research
research. тАЬItтАЩs important for context that basic researchers
& Innovation the first three years. It is currently funded by the
and clinical researchers understand each otherтАЩs work and
Research Institute, and Robinson trusts funding will continue
not be isolated in their own area. You have to think big;
to be available.
thatтАЩs how you innovate and find new treatments.тАЭ
In this project and everything she does, Robinson tends to
On the clinical side, she is also looking at change. The
push the limit. тАЬItтАЩs a hospital-wide attitude. Where others
increasing number of complex cases, including transplant
may say no, we will say yes. If not at SickKids, where else
patients, means that the demand for expertise is growing.
would you find this approach? ThatтАЩs part of what makes
SickKids such an exciting place.тАЭ
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
5
James Whitlock
Division Head
Haematology/Oncology
Whitlock: Building the best in the world
As well, Whitlock and his wife, Debbie, recent empty-nesters,
When Victor Blanchette completed his term as Head of
wanted to move to a тАЬreal city,тАЭ a place with more diversity
Haematology/Oncology this year, SickKids interviewed a
and opportunities than Nashville. What sealed the deal,
number of excellent candidates to fill the position. James
however, was the shared passion for helping children which
Whitlock from Vanderbilt University Medical Center and the
he found at SickKids.
Monroe Carell Jr. ChildrenтАЩs Hospital at Vanderbilt in Nashville,
Tennessee quickly emerged as number one.
Medicine has been a personal journey for Whitlock; he knew
His research interests include the biology and treatment of
represented the first generation in his family to attend college
childhood acute leukaemias, the development of new drugs
and enter medicine, he had no footsteps to follow in so he
he wanted to be a doctor from an early age, however, as he
for the treatment of childhood cancers, and the biology and
made his own path. He has found a similar sense of purpose
treatment of histiocytic disorders. He has received numerous
and ambition at SickKids.
honours and awards, and has authored or co-authored more
than 80 manuscripts and book chapters.
тАЬThis is a world-class hospital with renowned specialists, a
strong research institute, close ties to the community and an
SickKids wasnтАЩt the only place that expressed an interest in
recruiting Whitlock, but as it turned out Toronto had everything
amazing institutional culture with visionary leadership,тАЭ he says.
тАЬThe Haematology/Oncology program here is truly great тАУ but it
he was looking for. First of all, the city is home to leading
can be so much more. I think this will be the best childhood
faculty members, some of whom he already knew from his
cancer and blood diseases program in the world. That is our goal.тАЭ
work with the international ChildrenтАЩs Oncology Group,
including Sheila Weitzman, a world leader in histiocytosis.
Whitlock isnтАЩt just whistling Dixie. During his time at Vanderbilt,
its paediatric oncology program tripled in size and ranked
In WhitlockтАЩs words, scientists like Janet Rossant, SickKidsтАЩ
among the top 25 U.S. childrenтАЩs cancer programs in the
Chief of Research, and Peter Dirks, Principal Investigator at
2009-10 U.S. News & World Report survey. SickKids is already
The Arthur and Sonia Labatt Brain Tumour Research Centre,
a leader in paediatric cancer research and treatment. It is
have helped to make Toronto the тАЬworld capital of stem cell
reasonable to expect that even greater achievements will follow.
research,тАЭ which matters a great deal to an oncologist when
evidence is mounting that cancer is a stem cell disease.
6
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Hats Off! Successful teams are an inspiration
inside and outside SickKids
Model collaboration in
cystic fibrosis research
fine reputation in CF, he says. тАЬThe link at SickKids between
He accepted the offer to come to Toronto because of SickKidsтАЩ
SickKids is famous for its contributions to the fight against
clinical researchers and basic science researchers is unique.
cystic fibrosis. The gene defect that causes CF was discovered
For example, the clinical research team is now working with
at SickKids in 1988; today some of the worldтАЩs leading CF
basic scientists who use stem cells from patientsтАЩ skin to test
scientists work at SickKids where they keep looking for new
drugs that can correct the basic defect in CF lungs. These tight
and better ways to treat the disease.
collaborations help us to push ahead in pursuing new therapies.тАЭ
Even before the ground-breaking discovery by former SickKids
There is growing hope that CF can be controlled through the
scientist Dr. Lap-Chee Tsui and his team, SickKids was working
development of new drugs, says Ratjen. Earlier promises of
on CF and had developed a great deal of knowledge about the
gene therapy that would eradicate CF did not materialize, but a
disease and its treatment.
better understanding of the disease has led to new and exciting
therapies, some of which are already being tested in patients.
As the body of knowledge and expertise grew, SickKids decided
to establish the Cystic Fibrosis Centre in 2007. Care, research
Even before these therapies are brought to market, clinical
and learning are integrated with one overriding goal to improve
excellence and research have been highly successful, so much
the life and lifespan of CF patients.
so that CF is no longer considered a fatal childhood disease.
The centre is led by Felix Ratjen, Professor of Paediatrics, Head
while todayтАЩs median age of life expectancy for a child born
of Respiratory Medicine, H.E. SellerтАЩs Chair in Cystic Fibrosis
with CF in Canada is over 40 years.
Fifty years ago, patients were not expected to reach school age,
and Senior Scientist in Physiology & Experimental Medicine,
and Christine Bear, Senior Scientist in Molecular Structure &
Ratjen says that about five years ago, the number of adult CF
Function and Professor of Physiology and Biochemistry.
patients in Toronto exceeded the number of children with the
disease for the first time. This landmark event happened earlier
Ratjen did most of his medical training in Germany. After a
in Toronto than in many other centres around the world. Today
research fellowship at ChildrenтАЩs Hospital Boston, he was
SickKids has about 300 patients with cystic fibrosis compared
appointed Deputy Chief of the Department of Paediatrics at
to an adult population of 400 at the CF clinic at St. MichaelтАЩs
the University of Essen, Germany, in 1998 and Professor of
Hospital in Toronto.
Paediatrics in 2001. He served as Chief Executive of the
scientific board of the German CF foundation in 2002-05 and
тАЬAdvances made in the last decade are enormous,тАЭ Ratjen says.
was actively involved in the European Respiratory Society.
тАЬThis is a success story and it is linked to the unique working
relationship among scientists at SickKids.тАЭ
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
7
SickKids studies healthy children
health. тАЬThis is the first initiative of its kind,тАЭ says Parkin,
A hospital treats sick people and makes them better, however,
director of the Research and Fellowship Program in Paediatric
SickKids also studies children who are well and tries to
Medicine, senior associate scientist in Child Health Evaluative
understand what keeps them from getting sick.
Sciences and associate professor. тАЬThere are no other primary
care research networks like this in Canada.тАЭ
A couple of years ago, Drs. Patricia Parkin, Jonathan Maguire
and Catherine Birken agreed there was a need for information
The project would not exist, she says, without the partnerships
on how to maintain the good health that most people are born
with the Applied Health Research Centre at St. MichaelтАЩs
with. The problem is significant: by the end of childhood,
Hospital, the leading data coordinating centre at the University
40 per cent of Canadian children are dealing with preventable
of Toronto, and Mount Sinai Services where blood samples are
conditions, including obesity, asthma, injury, behaviour
tested using cutting-edge, high-throughput laboratory technology.
problems or learning difficulties, all of which can affect
people for the rest of their lives.
Birken, who is a staff paediatrician, a project investigator in
Child Health Evaluative Sciences and assistant professor, is
The three investigators established TARGetKids! (Toronto Applied
focusing on obesity, which is a serious problem among youth:
Research Group), an initiative that will show which childhood
six years ago, 26 per cent of Canadian children aged two to
conditions are associated with the most common adult diseases
17 were overweight. TARGetKids! will help to show if public
тАУ heart attacks, strokes, diabetes and cancer тАУ and how these
education programs or other interventions for pre-schoolers
diseases can be prevented at an early age. It is based on a
are lowering the number. тАЬWe are using knowledge translation
reciprocal arrangement with community paediatricians and
to work on obesity prevention,тАЭ says Birken. тАЬWe hope to learn
family physicians affiliated with the University of Toronto.
if we can develop tools for doctors in the community to identify
high-risk children, and if there is a critical time to intervene.тАЭ
The projectтАЩs current focus is on obesity and vitamin D and iron
deficiency. Data are captured from patients in community
Vitamin D levels have been linked to respiratory infections,
offices where parents fill in detailed questionnaires about their
asthma, diabetes, multiple sclerosis, and some cancers.
childтАЩs health, nutrition, lifestyle and behaviour. Both children
Maguire, a full-time physician at St. MichaelтАЩs, a part-time
and parents provide height, weight and waist circumference,
physician at SickKids and a scientist at both institutions,
and children give blood samples that are tested for nutritional
and an assistant professor, is the lead on the study of links
indicators including cholesterol, glucose, iron and vitamin D
between vitamin D and chronic health conditions.
levels. Results come back in a couple of days and are shared
with the community physicians, who otherwise wouldnтАЩt have
He is also involved in the work on iron deficiency, which is led
access to this kind of information. The project also offers
by Parkin. Early iron deficiency has been linked to delayed
community practitioners a meaningful way to work with
development, behaviour problems, school failure, lower
SickKids on research and scholarship.
employment, and an increased risk of stroke during childhood.
Parkin and Maguire have already shown there is an association
So far, 3,000 children up to the age of six have been recruited
between bottle use and iron deficiency and that community
in the greater Toronto area from Village Park Paediatrics,
physicians can influence when parents wean their children from
Clairhurst Paediatrics, Danforth Paediatrics, Mount Sinai Family
the bottle, thereby helping to reduce tooth decay, obesity and
Medicine, St JosephтАЩs Health Centre and St MichaelтАЩs Family
iron deficiency.
Medicine. The aim is to increase the number of study sites to
include urban children across Canada.
TARGetKids! has created excitement in CanadaтАЩs research
The first set of comprehensive data will be presented at the
$3.2 million from Canadian Institutes for Health Research, plus
community; already the project has received more than
2011 annual meeting of the Canadian Paediatric Society; any
sizeable grants from the St. MichaelтАЩs Foundation, University of
number of journal articles, abstracts and presentations will
Toronto, Dairy Farmers of Ontario, Danone, and The PhysiciansтАЩ
follow in years to come, adding new knowledge about childhood
Services Incorporated Foundation.
8
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Providing the best level of education
Successful team: Education scholarship
тАЬWe donтАЩt think itтАЩs enough only to educate paediatricians,тАЭ
he says. тАЬAt SickKids we want to provide the best level of
education and ensure that we enhance patient care.тАЭ And
Education is at the heart of the Department of Paediatrics,
education scholarship, that is studying the impact of our
and central to this function is Dr. Rayfel Schneider, Associate
educational endeavours, has become a preferred pathway
Chair of Medical Education.
for many entering an academic career in Paediatrics.
Under his committed and passionate leadership, the education
Success in RayfelтАЩs office is also measured in the awards his
office has thrived with a team that now includes Adelle
team members have won. This past year alone, Adelle Atkinson
Atkinson, Program Director for Postgraduate Medical Education,
was the first recipient of the Sarita Verma Award for Advocacy
Stacey Bernstein, Director of Undergraduate Medical Education,
and Mentoring in Postgraduate Medicine 2009-2010; Stacey
Suzan Schneeweiss, Director of Continuing Education, Tina
Bernstein, the Wightman-Berris Academy Award for Individual
Martimianakis, Education Researcher, and Shelley Weiss,
Teaching Excellence 2009-2010; Tina Martimainakis: The
Director of Faculty Development.
2010 Association of Medical Education of Europe (AMEE) Patil
Award for best Research in Medical Education Presentation,
The team is living proof that SickKids is much more than a hospital. тАЬInterdisciplinarity: At the intersection of knowledge-production
Academic paediatric health sciences institution describes much
and identity formationтАЭ; and Suzan Schneeweiss: Division of
better SickKids which has integrated patient care, research and
Paediatric Emergency Medicine Clinical Practice Award
education and taken paediatrics to a new level.
2009-2010.
SickKids is considered a national and international leader
Medical Education in Department of Paediatrics 2009-2010
in medical education. It houses a critical mass of leaders in
education, and they are setting their sights high, says Schneider.
тАв 224 medical students, increasing to 259 in 2011
тАв 76 core residents
тАв 71 sub-specialty residents
тАв 223 clinical fellows
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
9
Jaeggi and Jones promoted to Professors of Paediatrics
Edgar Jaeggi
Associate Scientist, Physiology
& Experimental Medicine
Staff Cardiologist; Head,
Fetal Cardiac Program
Nicola Jones
Senior Scientist, Cell Biology
Staff Gastroenterologist,
Gastroenterology,
Hepatology and Nutrition
Background тАУ Born and raised in Switzerland, obtained
Background тАУ Born in Cardiff, South Wales, grew up in Cobourg
medical degree from the University of Basel. Trained in general
and Oshawa, Ontario. University of Toronto Faculty of Medicine,
paediatric cardiology at the University ChildrenтАЩs Hospitals of
paediatrics training and paediatric gastroenterology fellowship
Z├╝rich and Geneva; Westmead Hospital in Sydney, Australia;
at SickKids, PhD in Molecular and Medical Genetics
Fetal and Interventional Cardiology at Sainte-Justine Hospital
Department at U of T.
in Montreal, and Electrophysiology at SickKids. Joined clinical
staff at University Hospital of Geneva in 1998, and returned
Research тАУ Enteric pathogens and how they interact with host
to Toronto in 2002.
cells to cause disease such as gastric cancer and inflammatory
bowel disease. Human beings have more bacteria in their
Research тАУ Current research areas include fetal intervention,
bodies than human cells тАУ we are really more bacteria than
fetal arrhythmias, and cardiovascular effects of intrauterine
human, sort of like condominiums for bacteria. These
growth restriction. Prenatal treatment, for example by catheter
microorganisms are very beneficial but can also cause disease.
intervention, is one of the most controversial and challenging
I am interested in figuring out how to harness the beneficial
issues in my field. It affects not one but two patients at the
features that promote health and how to prevent the diseases
same time and risks and benefits must be considered very
that these microorganisms can cause.
carefully.
All-time favourite scientist тАУ Leonardo da Vinci. He epitomizes
All-time favourite scientist тАУ Probably Dr. Abraham Rudolph,
a renaissance person and I admire his artistic abilities and
who has pioneered our understanding of fetal physiology and
how he integrated art and science. My favourite contemporary
is still considered one of the most distinguished paediatric
scientist is Dana Philpott from U of T, who is known for her work
cardiologists in the world. I met him once when I was working as
on innate immunity. She is very smart, a wonderful individual
a fellow in Z├╝rich and he visited us in Toronto in November 2010.
and a great role model for young people in science today.
Why science? тАУ For me, the question is more, тАШwhy medicine?тАЩ
Why science? тАУ I had not intended on being a scientist but was
It is through medicine that I came into science. We are all
exposed to research during my fellowship. I had an amazing
committed to trying to improve the well-being of our patients
mentor, Dr. Phil Sherman, the lab environment was fascinating
and I would hope that my research is contributing to finding
and I realized it was what I wanted to do. I saw that by studying
new methods for improving the quality of life and the outcome
disease mechanisms I could be a more effective physician.
of some of our patients.
Why SickKids? тАУ SickKids is a great place! There is
Why SickKids? тАУ SickKids is a world-renowned centre that
collaboration everywhere. As a clinician I work with patients
offers tremendous clinical and research opportunities. I have
and families, and the link between clinicians and scientists
held positions in five cardiac hospitals on three different
is fantastic.
continents in my professional career and none of them have
offered the kinds of opportunities that you find at SickKids.
10
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Medical Education Training and Scholarship
This past year, our Department proved once again why
Educational Administrative Staff
education is one of its core strengths. Our teachers, training
Mary Antonopoulos, Undergraduate Education
programs and students are making an impact locally, nationally
Joanna Barnes, Undergraduate Education
and internationally with their scholarly activity and their
Susan Jenkins, Administrative Supervisor
commitment to excellence in teaching and learning. This
Sandra Layno, Postgraduate Education
report serves to recognize the dedication of our teachers
Eleanor Mitchell, Postgraduate Education/Education Scholarship
and educators. It documents their achievements and outlines
Nicole Winters, Continuing Education
promising new directions for research, innovation, teaching
and application in medical education.
Education Researchers
Adam Dubrowski, PhD, Education Researcher, Learning Institute
Organization
Tina Martimianakis, PhD, Education Researcher,
Educational activities in the Department of Paediatrics are
Department of Paediatrics
led by Dr. Rayfel Schneider, the Associate Chair (Education)
Maria Mylopoulos, PhD, Education Researcher, Learning Institute
and the Medical Education Advisory Committee (MEAC) (see
Kathryn Parker, PhD, Education Consultant, Learning Institute
organizational chart below). The MEAC works to enhance
excellence in teaching and education, to increase the
Faculty pursuing formal training in education 2009-2010
recognition of the educational achievements of our faculty
Adelle Atkinson (Education Scholars Program)
within the Department and beyond, and to facilitate the
Angela Punnett (Masters in Education)
academic promotion of faculty and the career development
Michelle Shouldice (Masters in Education)
of clinical educators and teachers. It also establishes
Melinda Solomon (Masters in Education)
mentorship opportunities for faculty engaged in educational
Shelly Weiss (Education Scholars Program)
activities, fosters collaborations and networks with other
groups interested in education, and provides advice and
Trainees pursing formal training in education 2009-2010
guidance to the chair with regard to educational priorities.
Vicky Breakey (Masters in Education)
Elly Berger (Masters in Education)
Medical Education Advisory Committee
Membership 2009-2010
Clare Hutchinson (Masters in Education)
Rayfel Schneider (Chair)
Catherine Walsh (PhD in Education)
Sarah Schwartz (Masters in Education)
Adelle Atkinson
Stacey Bernstein
EDUCATIONAL TRAINING AND LEADERSHIP
Robert Hilliard
Undergraduate Education
Ann Jefferies
Our undergraduate program, led by Dr. Stacey Bernstein,
Karen Leslie
is actively building and enhancing the paediatric experiences
Tina Martimianakis
for students throughout the four years of medical school
Jonathan Pirie
training. There are currently 224 students in the first-year
Angela Punnett
class, with enrolment expected to increase to 250 students
Lisa Robinson
beginning in 2011.
Suzan Schneeweiss
Michelle Shouldice
In 2008-2009 we were excited to launch the Pediatric
Shelly Weiss
Longitudinal Experience (PedLE) which we offered to all our
first-year medical students. That year, 60 students spent three
half days with community paediatricians or SickKids faculty.
The program focused on increasing the studentsтАЩ paediatric
knowledge base and their comfort in interacting with children.
The program also gave students an opportunity to get a sense
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 11
of what it is like to be a paediatrician. The PedLE was well
We have continued to subscribe to the paediatric online
received and highly rated by the students. The following year,
interactive cases developed by the Council of Medical Student
140 students applied for the 60 spots and we expanded the
Education in Pediatrics (COMSEP). All third-year clerks must
experience to offer placements for 70 students over four
complete 10 cases. The cases are very well received and
half days. Thirty four SickKids faculty and 20 community
most students do more than the assigned number of cases.
paediatricians participated in teaching.
The students also spend 2-4 week blocks in the Electives
In the second year, the Art & Science of Clinical Medicine II
Program, which is popular among U of T, national and
(ASCMII) course runs over five consecutive Thursday mornings
international students. Over 226 elective students participated
five times per year. Last year 23 SickKids faculty, 11 clinical
in 2009-2010. Our Social Paediatrics elective continued to be
fellows and 31 community paediatricians taught ASCMII. We
a popular and highly sought-out experience for clerks. In the
pushed back our starting time by half an hour to get two more
revised clerkship curriculum, all core rotations are front- loaded
hours of clinical experience for the students. Our tutors once
in third year. The entire fourth-year class in 2011-12 will have
again received exceptionally high teaching evaluation scores
electives from September to December 2011. We expect fierce
from the students.
competition for the coveted elective spots! All students will
have тАЬselectivesтАЭ between January and April 2012.
For the 2010-11 year, we are planning to amalgamate two of
the second-year courses тАУ Pathobiology of Disease (PBD) and
Postgraduate Education
FMP (Foundations of Medical Practice) into a new and improved
The Postgraduate Paediatric Training Program in the
course called Mechanisms, Manifestations and Management
Department of Paediatrics is led by Dr. Adelle Atkinson. This
of Disease (triple M-D). Hosanna Au has assumed leadership
continues to be the largest training program in Canada with
as manager of the paediatric weeks of the course.
unparalleled resources both in the area of depth and breadth
of patient experiences, as well as an outstanding teaching and
The third-year clinical clerks are integrated into community
research faculty. The program attracts the most outstanding,
hospitals with half of the class spending their full six-week
sought-after candidates in the country. Applicant numbers
rotation in one of 12 community hospital sites. The other
continue to increase yearly, including international medical
half spends three weeks in community paediatric offices and
graduates. The program is rich in diversity. Specifically, we
three weeks at SickKids on the general paediatric wards, in
have 75 core residents, 62 subspecialty residents, and 214
Emergency Medicine or Adolescent Medicine. This year we
clinical fellows enrolled in the 2009-10 academic year. The
sent six students to Credit Valley Hospital for their six-week
Department of Paediatrics is home to 17 residency training
placement. With rave reviews and less than a year to the
programs accredited by the Royal College of Physicians and
opening of the Mississauga Academy of Medicine (MAM), we
Surgeons of Canada.
are sending eight students to Credit Valley Hospital for the
2010-11 academic year. The students and residents were
The success of the training program is largely due to faculty
hard at work this summer leading an initiative to develop
engagement in the process. An active Residency Program
a тАЬPeds On the GoтАЭ handbook for the third-year clerks.
Committee oversees the administration and running of the
training program, and various subcommittees exist to ensure
Over the past two years, the clerkship (years three and four)
that each part of the program (resident selection, academic
were completely revamped and the new curriculum will be
curriculum, evaluation, research, mentoring) are delivered in
launched in 2010-11. Students have portfolio groups that
an evidence-based fashion with scholarship as a natural part
meet five times a year тАУ chaired by a faculty member (Academy
of the process.
Scholar) and resident (Junior Academy Scholar) with a focus
on discussing the experience of becoming a physician and
the non-medical expert CanMEDs roles.
12
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
The curriculum of the program is in constant evolution
leadership of the resident group. This year, a new initiative
responding to resident feedback, Ministry of Health & Long-
was undertaken by the residents to partner with the Gosford
Term Care priorities and the changing landscape of our
Park Public School which is located in a disadvantaged
community. The fourth year of the program has been
neighbourhood. All residents have the opportunity to
redesigned and currently addresses the needs of our trainees
participate in this and the other advocacy projects,
who are pursuing a career in community paediatrics. There is
which add important dimensions to resident training.
an emphasis on a significant amount of community experience
with distributed education, as well as other important areas,
Last spring saw the first national Canadian Paediatric
such as child maltreatment and paediatric psychiatry.
Subspecialty Match. The University of Toronto subspecialty
programs matched 25 candidates, accounting for almost
The academic half day has undergone an evolution over the
40 per cent of all matched subspecialty positions across the
last several years with the insertion of a number of тАЬsub-
country. The residents from our own Core Paediatric Program
curriculaтАЭ to fully address all the CanMEDS roles. These
who entered the match did extremely well with a 100 per cent
include the Acute Care and Resuscitation Program (ACRP),
match rate. Outstanding candidates from other universities
Paediatric Psychiatry, Advocacy and soon a curriculum in
across Canada filled approximately 50 per cent of the University
Palliative Care as well as Dermatology. The ACRP continues to
of Toronto matched positions. The subspecialty programs
grow and mature and is the first program of its kind in Canada.
continued to attract excellent applicants from around the world.
Resident scholarship continues to be of a high standard with
Continuing Education
all residents being engaged in scholarly activities, including
The goal of our continuing education office is to promote
clinical research, education, patient safety, quality assurance
development and dissemination of continuing education
and patient advocacy. Some of our projects are initiated and
activities locally, nationally and internationally. Our Continuing
led by our trainees, others by our teachers and educators.
Education Committee (CEC), led by Suzan Schneeweiss, is
Some of the scholarly activities explore aspects of our
comprised of both academic and community-based health care
programming and aim to improve our curriculum and teaching.
professionals. Library services also help to support CE activities.
Recently, the residents studied a portion of the ACRP in a
There is strong collaboration with the University of Toronto,
scholarly way and had their work accepted in poster form at
Office of Continuing Education and Professional Development,
two national conferences. In a separate project, barriers to
and the Centre for Faculty Development. The CEC develops and
resident research are being explored. The aim of this study
supports a breadth of programming. Dr. Schneeweiss has also
is to develop recommendations for improving the scholarly
collaborated with the Office of CEPD at the University of Toronto
development of trainees. We have also started mapping the
to provide faculty development opportunities in continuing
social paediatric content of the program. One of the aims of
education. She worked with the Centre for Faculty Development
this study is to look at the attitudes and experiences related
to provide workshops on achieving higher level evaluations
to teaching and learning social paediatric content.
and use of an audience response system.
A primary focus for the program this past academic year has
Faculty members of the Department of Paediatrics have
been on teaching and evaluating the CanMEDS roles. There is
been active in continuing education activities for the
a robust CanMEDS curriculum within the academic half day,
2009-10 academic year. In addition, Dr. Savithiri Ratnapalan
which covers a wide variety of topics and a CanMEDS OSCE
successfully conducted her third annual longitudinal Project
offered each spring with almost 100 trainees taking part in
Planning and Management Course. City Wide Rounds,
this evaluative activity.
organized by Drs. Mark Feldman and Michael Peer from the
Advocacy continues to be a focus of the program. There are
event, attracting 120 community-based paediatricians and
currently four major advocacy projects underway under the
taking place four times annually.
Division of Paediatric Medicine, continues to be a popular
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 13
The Department of Paediatrics continues to have a strong
There was outstanding faculty contribution with 80 members
commitment to excellence in continuing education with ongoing
of our faculty presenting at this event. This year, a nephrology
courses, conferences and faculty development activities.
and urology subspecialty day, under the direction of Drs. Diane
The Annual Paediatric Update (course director: Dr. Suzan
Hebert and Walid Farhat, was presented with a comprehensive
Schneeweiss) was held April 14-17, 2010 and is the largest
look at the evaluation and management of common renal and
conference by the Department of Paediatrics attracting a local,
urologic disorders in children.
national and international audience with over 250 participants.
Finally, many of our divisions have been engaged in a variety of continuing education events:
Division
Adolescent Medicine
CE Leaders
Event
Dr. Debra Katzman
One-day conference reuniting past SickKids Adolescent
Bloorview Kids Rehab
Dr. Golda Milo-Manson
Clinical and Metabolic Genetics
at The Hospital for Sick Children
and Mount Sinai Hospital
Dermatology
Dr. David Chitayat
Medicine fellows with the aim of creating a wider Adolescent
Medicine community-of-practice and developing a spirit
of global cooperation among colleagues
Two-day Child Development Update designed to link current
developmental paediatric research and its translation into
clinical paediatric practice
18th annual symposium on New Developments in Prenatal
Diagnosis and Medical Genetics
Drs. Miriam Weinstein
and Elena Pope
One-day Paediatric Dermatology Update aimed at
community-based practitioners
Haematology/Oncology
Dr. Angela Punnett
Second annual Paediatric Chemotherapeutics Update
Motherisk Program
Dr. Gideon Koren
Motherisk Program 2010 - Pregnant and Lactating Women
Neonatology
Dr. Hilary White and
Ms. Annette Martens
Annual Acute Care Transport Course which was held in
conjunction with the Annual Paediatric Update
Neurology тАУ
Centre for Brain and Behaviour
Dr. Carter Snead
Three-day international symposium on brain injury in children
Paediatric Emergency Medicine
Dr. Amina Lalani
6th annual Paediatric Emergency Medicine Conference
attracting more than 150 participants.
Paediatric Emergency Medicine
Dr. Sanjay Mehta and
Dr. Suzan Schneeweiss
Advanced Pediatric Life Support course тАУ
delivered three times over the course of the year
Paediatric Emergency Medicine
Dr. Suzan Schneeweiss
Paediatric Emergency Procedural Sedation Course тАУ
delivered four times over the course of the year
Paediatric Emergency Medicine
Drs. Amina Lalani
and Sanjay Mehta
Pediatric Emergency Trauma Course тАУ
held twice in the last academic year
Rheumatology
14
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
The Division celebrated 25 years of subspecialty programming
and hosted a тАЬCelebration of ExcellenceтАЭ during which former
trainees were invited to participate in a two-day academic
symposium covering the field of paediatric rheumatology
FACULTY DEVELOPMENT
In addition, a database was created to capture scholarly
The Faculty Development subcommittee of the Medical
activity. Several presentations regarding our DepartmentтАЩs
Education Advisory Committee, led by Karen Leslie, has
educational strengths and contributions were delivered
developed and delivered an annual medical education day
drawing on empirical data from this database, showcasing
to promote faculty development in education. This event was
our educational activities and productivity, but also pointing
started in 1999 by Dr. Jonathan Hellmann. Over the past
to opportunities for growth.
10 years, invited speakers have addressed a range of topics/
technology in education, interprofessional education, the
LEADERSHIP IN EDUCATION BEYOND
THE DEPARTMENT OF PAEDIATRICS
role of feedback in learning, team-based communication and
Several of our faculty members hold key leadership positions in
themes including simulation-based learning, the role of
mentoring. The objectives of the day are to inform Department
education beyond the Department of Paediatrics, demonstrating
members about developments in medical education and
our growing capacity to inform educational practice more
promote scholarship and research in medical education.
broadly. Dr. Karen Leslie began her term as Director of the
Centre for Faculty Development (CFD) in the fall of 2009. In
In 2010, Medical Education Day showcased emerging
this new role, she has enhanced the programming available
knowledge in medical education with a grand rounds
through the CFD and led many exciting new initiatives. Dr. Jay
presentation by Dr. Kevin Eva from McMaster University.
Rosenfield continues as Vice-Dean of Undergraduate Medical
Dr. Eva is the current editor of Medical Education, one of the
Education at the University of Toronto. In Novemeber 2009,
premier medical education journals. Dr. Eva is widely known
Dr. Norman Rosenblum was appointed Associate Dean,
for his research in the area of assessment. He presented an
Physician Scientist Training, at the Faculty of Medicine.
engaging and thought-provoking grand rounds, followed by a
Dr. Susan Tallett holds the position of Chief of Education
practical workshop on assessment strategies. The day ended
of the SickKids Learning Institute and chairs the Education
with two presentations of education research by Drs. Ann
Subcommittee and the Continuing Professional Development
Jefferies and Tina Martimianakis.
Committee of the Canadian Paediatric Society. Finally,
Dr. Jonathan Pirie co-leads the procedural lab in the Learning
In July 2010, Dr. Shelly Weiss was appointed Director of Faculty
InstituteтАЩs simulation program.
Development. In her new role, and with the support of the Faculty
Development Committee, she will focus on evolving strategies to
support and mentor faculty in their academic and clinical activities.
HONOURS AND AWARDS
International
Jefferies A, Shah V: Association for Medical Education in
MEDICAL EDUCATION SCHOLARSHIP
Europe (AMEE) Patil Award for novel contribution in Teaching
This past year, Dr. Tina Martimianakis and members of the
and Learning. Presentation - тАЬImplementing practice change:
Educational Scholarship Enhancement Committee (ESEC)
What educational methods are effective?тАЭ, August 2010.
have worked to capture and document scholarship activity,
as well as develop programming to enhance faculty skills in
Martimianakis MA: Association for Medical Education in Europe
educational research, teaching, innovation and application. In
(AMEE) Patil Award for best Research in Medical Education.
September 2009, Medical Education Scholarship Rounds was
Presentation - тАЬInterdisciplinarity: At the intersection of
launched. The rounds are accredited and provide a forum for
knowledge-production and identity formationтАЭ, August 2010.
members of the department to share their scholarly activity as
well as take part in faculty development sessions designed to
Rapoport A: Scholarship: The program in palliative care
build skills in education research methodology. The sessions
education and practice - Pediatric track. Harvard Medical
focused on such diverse topics as clinical excellence, expertise,
School, Boston, MA, 2010.
educational program evaluation, interviewing methodology,
experimental methods and ethical guidelines, drawing heavily
on the expertise of educators within the Department.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 15
National
Walsh C: University of Toronto Standardized Patient ProgramтАЩs
Coffey M, Tallett S, Thomson K, Matlow A: Best Poster Award:
25th Anniversary Grant, 2010.
Knowledge and attitudes of paediatric residents regarding
communication around medical errors: The importance of social
Walsh C: Network of Excellence in Simulation for Clinical Teaching
context. Canadian Patient Safety Symposium, Montreal, 2009.
and Learning, Innovation and Evaluation Project Grant, 2009.
Jarvis A: Michel Weber Education Award for Sustained
Weitzman S: Excellence in Postgraduate Medical Education
Contribution to Paediatric Education in Canada, Canadian
Award, University of Toronto, 2010.
Paediatric Society, 2010.
Departmental
Jarvis A: First Recipient, Paediatric Emergency Section
Chitayat D: Continuing Medical Education Award to the faculty
Education Award, Canadian Paediatraic Society, Award
member who has demonstrated excellence in course
was created and named in Dr. JarvisтАЩ honour for sustained
coordination or teaching in a Department of Paediatrics/
contribution to education in the subspecialty, 2010.
University of Toronto Continuing Education sponsored event.
Walsh C: Canadian Child Health Clinician Scientist Program
Feldman: Marvin Gerstein Award to a part-time member of the
Doctoral Award from the Canadian Institutes of Health
Department of Paediatrics who has demonstrated excellence
Research, 2009.
in teaching as nominated by core paediatric residents.
Provincial
Friedman J: Harry Bain Award for Excellence in Clinical Teaching
Feldman M: Barry Zimmerman Memorial Prize - Continuing
to a full-time member of the Department of Paediatrics who
Education - for dedicated work on behalf of children for the
has demonstrated excellence in teaching as nominated by core
Electronic Child Health Record of Ontario, 2009.
paediatric residents.
University
Gans M: Postgraduate Community Teaching Award in
Atkinson A: Recipient of the 2010 Sarita Verma Award for
recognition of excellence in the teaching of paediatric
Advocacy and Mentorship in Postgraduate Medicine.
residents within community-based hospitals and offices.
Bernstein S: Wightman-Berris Academy Undergraduate
Hamilton J: POWER Teacher Award, Department of Paediatrics,
Individual Teaching Award, University of Toronto, 2010.
University of Toronto: Outstanding Contributions to
Postgraduate Teaching, 2010.
Jarvis A: Clinical Inter-professional Collaboration and Education
Award, Michener Institute of Applied Health Sciences, PALS
Jacobson S: POWER Teacher Award, Department of Paediatrics,
Advisory Team (Chairperson), 2009.
University of Toronto: Outstanding Contributions to
Postgraduate Teaching, 2010.
Jarvis A: University of Toronto Medical Society created an
annual prize in Dr. JarvisтАЩ name in honor of her contribution as
Jarvis A: Continuing Medical Education Award to the faculty
Associate Dean, Health Professions Student Affairs, Faculty of
member who has demonstrated excellence in course
Medicine, for students who demonstrate outstanding qualities
coordination or teaching in a Department of Paediatrics/
of caring and support offered to their peers, 2009.
University of Toronto Continuing Education sponsored event.
16
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Jarvis A: Continuing Education Award for Sustained Excellence
Tse SML: Department of Paediatrics Scholarship for Education
and Contribution, Department of Paediatrics, University of
Scholar Program, Centre for Faculty Development, University
Toronto, 2010.
of Toronto, 2010.
McNamara P: POWER Teacher Award, Department of
Wales P: POWER Teacher Award, Department of Paediatrics,
Pediatrics, University of Toronto: Outstanding Contributions
University of Toronto: Outstanding Contributions to
to Postgraduate Teaching, 2010.
Postgraduate Teaching, 2010.
Mendoza R: Subspecialty Teaching Award to the faculty
Walsh C: Department of Paediatrics Research Fellowship
member who has demonstrated commitment to excellence
Award, Hospital for Sick Children, 2009.
in teaching the subspecialty residents and clinical fellows.
Divisional
Nofech-Mozes Y: The Undergraduate Community Teaching
Al-Zaidy S: CanMeds Trainee Award, Division of Neurology,
Award in recognition of excellence in the teaching of medical
Hospital for Sick Children, 2010.
students within community-based hospitals and offices.
Benseler S: James C. Fallis Teaching Award, Division of
Punnett A: R.H.A. Haslam Preclerkship Teaching Award to
Paediatric Emergency Medicine, The Hospital for Sick Children,
the faculty member who has demonstrated excellence in
2009-2010.
preclerkshop teaching.
Donner E: CanMeds Faculty Award, Division of Neurology,
Roberts W: POWER Teacher Award, Department of Paediatrics,
Hospital for Sick Children, 2010.
University of Toronto: Outstanding Contributions to
Postgraduate Teaching, 2010.
Elbers J: William J. Logan Award for Excellence in Clinical Teaching,
Division of Neurology, The Hospital for Sick Children, 2010.
Saunderson J: The Lionel Weinstein Clerkship Teaching Award
to the faculty member who has demonstrated excellence in
Feldman M: Best Clinical Teacher Award, Paediatrics,
clerkship teaching.
St. JosephтАЩs Health Centre, Toronto, 2009.
Scolnik D: POWER Teacher Award, Department of Paediatrics,
Goh E: Joe T.R. Clarke Award (Teaching Excellence),
University of Toronto: Outstanding Contributions to
Division of Clinical and Metabolic Genetics, May 2010.
Postgraduate Teaching, 2010.
Jefferies A: Excellence in Teaching Award, Neonatal-Perinatal
Sung L: POWER Teacher Award, Department of Pediatrics,
Division, University of Toronto, June 2010.
University of Toronto: Outstanding Contributions to
Postgraduate Teaching, 2010.
Lalani A: Best presentation, James C. Fallis Teaching Award
for Paediatric Emergency Medicine Fellows Rounds,
Tse S: PERLs Award (Paediatric Educational Resident Lecture
The Hospital for Sick Children, 2009-2010.
Series Award) to the faculty member who has demonstrated
commitment to excellence in teaching at the Paediatric
academic sessions.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 17
Moharir M: William A. Hawke Award for Excellence in
Educational Development Fund, UofT
Clinical Teaching, Division of Neurology, The Hospital
The Educational Development Fund aims at тАЬcatalyzing
for Sick Children, 2010.
initiatives that immediately and directly impact University of
Toronto Faculty of Medicine education and teaching programs
Punnett A: Alvin Zipursky Teaching Award, Division of
through innovation and developmentтАЭ. In a highly competitive
Haematology/Oncology, The Hospital for Sick Children, 2010.
year, the following project received funding:
EDUCATIONAL FUNDING
The interprofessional OSCE development simulation tool
In the past academic year, our faculty, residents and fellows
(part II). Simmons B, Reeves S, Wagner S. Educational
also had significant grant capture with 42 awards totaling
development fund - University of Toronto/The University of
$2,284,167.64 (multi-year funds have been adjusted to reflect
Toronto Office of Interprofessional Education ($16,827 2009)
monies allotted for one academic year in the calculation of
this total) to pursue research in education.
Preparation for a career in academic medicine: Understanding
the process of peer-group mentoring for postgraduate trainees.
Paediatric Consultants Education Research Grant, SickKids
Leslie K, Breakey V, Lingard L. Education Development Fund
In the 2009-2010 academic year, four Paediatric Consultants
($5,280 2009)
Education Research Grants were awarded to faculty members
pursuing research which promises to increase understanding of
Other Funding Sources
educational phenomenon and contribute to theory building on
An important component of our educational research activity
such topics as research methods, attitudes and perceptions to
involves collaborations that span departments and institutions.
teaching, career decision-making and technologically enhanced
Furthermore, our faculty were involved in collaborative research
learning. The projects awarded also hold potential to enhance
projects that were merited with funding from a variety of
our local educational practices.
sources including the Royal College, Canadian Institutes
of Health Research and the Ministry of Health.
Dubrowski A: Testing the effectiveness of an Internet mediated,
video based, educational networking instrument in preparing
A CIPP framework for implementation and evaluation of a
trainees for simulation-based teaching of fundamental
faculty development program for neonatal-perinatal medicine.
technical skills. A randomized control study ($5,000).
Jefferies A, Finan E, Lee KS, Simmons B. Continuing Education
Shouldice M: Career decision making in pediatric residency
($4,900 2010-2011)
Research and Development Grant, University of Toronto
($5,000).
A comparison of debriefing methods following simulated
Thull-Freedman J: Understanding the paediatric literature:
neonatal resuscitation. Williams C. NRP Research Grant
What statistical and epidermiological concepts do clinicians
($16,180 2010)
need to know? ($4,500).
A qualitative observational study of resident oral pediatric
Weiss S: Attitudes, experiences and perceptions of faculty
developmental case presentations. Orsino A, Kawamura A,
with a revised curriculum incorporating the CanMEDS
Lingard L, Fehlings D. Bloorview Research Institute Seed
competencies ($4,890).
Grant Competition ($10,552 2008-2009)
18
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
A training cascade for Ethiopian surgical and obstetrical care:
Development of an internet-based psycho-educational program
An interprofessional, educational, leadership and skills training
for school-age children with arthritis and their parents: Phase 1.
program. M. Derbew, A. Dubrowski, R. Kneebone. Development
Feldman B, Stinson J, Duffy C, Huber A, Tucker L, McGrath P,
Partnership in Higher Education: British Council (2008-2011
Tse S, Hetherington R, Spiegel L, Campillo S, Benseler S.
$130,000)
Canadian Arthritis Network SRP Grant ($240,000 2009-2010)
Advancing faculty development: A systematic review.
Development of a virtual learning environment for
Reeves S, Leslie K, Egan-Lee E, Baker L Leslie K, Egan-Lee E,
interprofessional education in critical care. Kapralos B,
Baker L. Royal College of Physicians and Surgeons of Canada
Dubrowski A, Hogan M, Mallette M, Hogue A, Shi, W.,
($4,950 2010)
Goldsworthy, S. Inukshuk Wireless Content Development
Projects ($133,000 2009-2010)
An interprofessional team orientation experience. Mehta A,
Honeyford L, Punnett A. C17 Education Grant Competition
($1,910 2009-2010)
Effect of expert versus peer (intra-professional versus
inter-professional) feedback on the acquisition of urinary
catheterization skills. Walsh C, Carnahan H, Dubrowski A,
Assessment and evaluation of a pilot interprofessional OSCE
Backstein D, Ling SC, Rose D. Network of Excellence in
(iOSCE). Simmons B, Reeves S, Wagner S. Undergraduate
Simulation for Clinical Teaching and Learning Innovation
Medical Education Curriculum Renewal Fund тАУ University of
and Evaluation Projects Grant ($24,743 2009-2010)
Toronto/The University of Toronto Office of Interprofessional
Education ($19,141 2009)
E-learning interprofessional curriculum resources for pre-
Assessment and evaluation of a pilot interprofessional OSCE
J, McGillion M, Lax L, Hunter J, Dubrowski A, Henry J. Canadian
(iOSCE). Simmons B, Reeves S, Wagner S. Matching Funds
Institutes of Health Research Community Alliances for Health
licensure health science students across Canada. Watt-Watson
Medical Council of Canada/The University of Toronto Office
Research & Knowledge Exchange on Pain ($350,000
of Interprofessional Education ($10,000 2009)
2008-2012)
Canadian Child Health Clinician Scientist Program.
Enhancing patient safety using web based simulation project.
Rosenblum N, Lee S. Canadian Institutes of Health Research
Glover Takahashi S, Matlow A, Tallett S, Bandiera G, McIlroy J:
($4,500,000 2002-2015)
Network for Excellence in Simulation for Clinical Teaching
and Learning ($50,000 2009-2010)
Design and evaluation of an Interprofessional OSCE (Objective
Structured Clinical Examination) Development (IpOD)
Evaluation of case-based Interprofessional Education (IPE)
simulation tool. Simmons B, Reeves S, Wagner SJ. Network
sessions: Development and implementation. Wagner S, Reeves
of Excellence for Simulation in Clinical Teaching and Learning
S, Simmons B. Undergraduate Medical Education Curriculum
($49,200 2009-2010)
Renewal Fund тАУ University of Toronto/The University of
Toronto Office of Interprofessional Education ($13,951 2009)
Development and validation of an objective skill assessment
tool for colonoscopy. Walsh C, Carnahan H, Ling SC, Khanna N,
Exploring adaptive expertise in inter-professional team practice.
Walters T, Rabeneck L, Reznick R. American Society for
Mylopoulos M. SickKids Research Institute New Ideas Grant
Gastrointestinal Endoscopy (ASGE) Quality in Endoscopy
($27,612 2009)
Research Award Application ($75,000 2009-2010)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 19
Exploring mentorship as a strategy to build capacity for
Integration of bio-physiological information with a point-of-care
knowledge translation research and practice. Gagliardi AR,
decision support system for safer patient care. Doran DM,
Bell M, Leslie K, Levinson W, Straus S, Morrison L,
Goubran R, Doherty S, Knoefel F, Dubrowski A. Collaborative
Tourangeau A, Rotstein O, Silver I. Canadian Institutes
Health Research Projects тАУ Natural Sciences and Engineering
of Health Research ($83,765 2009-2010)
Research Council/Canadian Institutes of Health Research
($455,310 2008-2010)
Faculty development to support capacity building for Interprofessional education. Leslie K. Reeves S, Silver I, Merkley J,
IP-COMPASS: Interprofessional Collaboration Organization
Richardson D, Wagner S, Andrews M, Kwan D. Ministry of
Measurement & Performance Assessment. Oandasan I,
Health and Long-Term Care ($310,000 2008-2009)
Lowe M, Parker K, Pauze E, Simmons B, Sinclair L, Wagner SJ.
Feasibility of an interactive web-based rheumatology teaching
($580,000 2008-2009)
Interprofessional Care/Education Fund тАУ Health Force Ontario
module for pediatric residents. Tse SM, Feldman BM,
Schneider R, Hyman A, Stringer E, Bassilious E, Batthish M,
Partnered learning project. Lingard L, Durrant M, Fleming-
Bendiak G, Gupta S, Bradley N, Cameron T, Tait G, Shouldice M.
Carroll B, Lowe M, Nicholas D, Reisman J, Sinclair L, Tallett S.
Educational Deans Funds Matched with Department of
HealthForceOntario ($413,553 2007-2009)
Paediatrics Fund ($18,300 2007-2009)
Partnerships for health improvement/building skills,
Health education and learning practices promoting social
changing practice: Simulator training for hand hygiene protocols.
inclusion of children with developmental disabilities. Minnes P,
McGeer A, Dubrowski A, Beduz MA. Canadian Patient Safety
Hutchinson N, Perry A, Isaacs B, Ouelette-Kuntz H, Loh A,
Institute/Canadian Institutes of Health Research ($425,616
Cornish K, Dionne C, Nachshen J, Versnel J, Weiss J. Canadian
2009-2011)
Institutes of Health Research ($299,995 2009-2011)
Physician-researchers in pediatrics: A study on dual
Image, text, sound and technology program. Interactive
accountability. Zlotnik RS, Boydell K, dтАЩAjincourt-Canning L,
community simulation environment for public health
Simpson C, Levin A, McDonald N, McFadden J, Sampson H,
curriculums. Kapralos B, Hogan M, Muirhead B, Dubrowski A.
Schneider R, Strahlendorf C. Canadian Institutes of Health
Social Science and Humanities Research Council of Canada
Research ($78,398 2008-2010)
($49,452 2009-2010)
Resuscitation competencies in inter-professional education
Innovations and evaluation projects. Effectiveness of an
(ReCIPE). Simmons B, Reeves S, Deland M. Neonatal
internet mediated, networked learning instrument in simulation
Resuscitation Program Research Grant тАУ Canadian Paediatric
based training of clinical tasks. Dubrowski A, Barry M,
Society ($17,590 2009-2010)
Carnahan H, Kapralos B, MacDonald-Jenkins J, Rose D, Safir O,
Backstein D. The Network of Excellence in Simulation for
Clinical Teaching and Learning ($37,128 2009-2010)
Self-regulated motor learning: Mechanisms and application.
Dubrowski A. Natural Sciences and Engineering Research
Council ($75,000 2008-2013)
Innovations and evaluation projects. Linking learning objectives
with simulators тАУ Understanding how health care professionals
Sustainability grant for IPE development at the University of
learn clinical tasks using simulation. Brydges R, Dubrowski A,
Toronto Office of Interprofessional Education. Oandasan I,
Mallette C, Pollex H, Carnahan H. The Network of Excellence
Wagner S, Lowe M, Sinclair L, Tassone M, Simmons B,
in Simulation for Clinical Teaching and Learning ($35,452
Parker K. Ontario Ministry of Training for Colleges and
2009-2010)
Universities ($150,000 2009)
20
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
System level evaluation of the ACPAC program graduates:
Bismilla Z, Finan E, McNamara PJ, LeBlanc V, Jefferies A,
Determining collaborative practice behavior following the
Whyte H: Failure of paediatric and neonatal trainees to meet
introduction of an APP in arthritis care across diverse clinical
Canadian neonatal resuscitation program standards for
settings in Ontario: Lundon K, Shupak R, Lineker S, Schneider R,
neonatal intubation. Journal of Perinatology 2010: 30(3):
Passalent L, Sinclair L, Kennedy C. Canadian Initiative for
pp 182-187.
Outcomes in Rheumatology Care (49,898 2010-2011)
Bollegala N, Garfield H, Scott IM, Wright BJ, Brenneis FR,
The interprofessional OSCE development simulation tool (part I).
Atenafu E, Feldman M: The clerkship pediatric rotation:
Simmons B, Reeves S, Wagner S. Network of Excellence in
Does setting matter? Canadian Medical Education Journal
Simulation for Clinical Teaching and Learning/The University
2010: 1(1): pp 51-55.
of Toronto Office of Interprofessional Education ($49,200 2009)
Brydges R, Dubrowski A: Collision error avoidance: Influence of
Utilizing teaching evaluations to promote faculty development
proportion congruency and sensorimotor memory on open-loop
in teaching. Leslie K, Lieff S, Pittini R, Reeves S, Schrieber M.
grasp control. Experimental Brain Research 2009: 198(4):
Undergraduate Medical Education Curriculum Renewal Fund
pp 445-453.
($19,630 2009)
Brydges R, Farhat W, El-Hout Y, Dubrowski A: Pediatric
SHARING OUR KNOWLEDGE DISCOVERIES
urology training: Performance-based assessment using the
Our educational research and scholarship is disseminated
fundamentals of laparoscopic surgery. Journal of Surgical
regularly in leading clinical and educational journals. This
Research 2009: January 24 [Epub ahead of print].
past academic year, our faculty and residents the following
peer-reviewed publications and two book chapters.
Brydges R, Carnahan H, Dubrowski A: Assessing skills in
a self-guided learning setting: Absolute symmetry error.
Peer Review Publications
Advances in Health Sciences Education 2009: January 9
Baker L, Egan E, Martimianakis MA, Reeves S. Relationships of
[Epub ahead of print].
power: Implications for interprofessional education and practice.
Journal for Inter-professional Care 2010: Early Online Release.
Brydges R, Carnahan H, Safir O, Dubrowski A: Probing the
effectiveness of directed self-guided learning of clinical
Baker L, Reeves S, Egan-Lee E, Leslie K, Silver I: The ties that
technical skills in a simulated setting. Medical Education
bind: A network approach to creating a program in faculty
2009: 43(6) pp 507-515. Commentary: Hays R: pp 505-506.
development. Medical Education 2010: 44(2): pp 132-139.
Busing N, Slade S, Rosenfield J, Gold I, Maskill S: In the spirit
Baker L, Egan-Lee E, Leslie K, Silver I, Reeves S: Exploring an
of Flexner: Working toward a collective vision for the future of
IPE faculty development program using the 3-P model. Journal
medical education in Canada. Academic Medicine 2010: 85(2):
of Interprofessional Care 2010: 24(5): pp 597-600.
pp 340-348.
Batthish M, Bassilious E, Blanchette N, Soon G, Luca N, St
Carnahan H, Dubrowski A, Grierson LEM: Temperature
Bernard R, Cameron T, Bahr T, Hyman A, Tait G, Feldman B,
influences both haptic perception and force production when
Schneider R, Tse SML: The development of an interactive
grasping. International Journal of Industrial Ergonomics 2010:
web-based rheumatology teaching module. Arthritis &
40: pp 55-58.
Rheumatism 2009: 60(10): p 508.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 21
Coffey M, Tallett S, Thompson K, Matlow A: Knowledge and
Gropper R, Harnett N, Parker K, Pearce S, MacIver D, Murray L,
attitudes of paedatric residents toward disclosure of adverse
Ramsay L, Ripley A, Sands B, Zychla L: The path to simulated
events. Canadian Paediatric Society, Ottawa, ON. Paediatric
learning: Developing a valid and reliable tool to evaluate
Child Health 2009: 14: p 41A.
radiological technology studentsтАЩ performance in patient
interactions Journal for Allied Health 2010: 39(1): pp 28-33.
Daneman D, Kennedy J, Coyte P: Evaluation of the Career
Development and Compensation Plan in the Department of
Hodges BD, Maniate J, Martimianakis MA, Alsuwaidan M,
Paediatrics at The Hospital for Sick Children. Healthcare
Segouin C: Cracks & crevices: Globalization discourse and
Quarterly 2010: 13: pp 64-71.
medical education. Medical Teacher 2009: 31(10): pp 910-917.
Doran DM, Haynes RB, Kushniruk A, Straus S, Grimshaw J,
Khokhotva M, Backstein D, Dubrowski A: Performance error
Hall LM, Dubrowski A, Di Pietro T, Newman K, Almost J, Nguyen H,
is not necessary for learning of orthopaedic bone drilling.
Carryer J, Jedras D: Supporting evidence-based practice for
Canadian Journal of Surgery 2009: 52(2): pp 98-102.
nurses through information technologies. Worldviews Evidence
Based Nursing 2009: December 16 [Epub ahead of print].
Koontz MB, Cuttler L, Palmert MR, OтАЩRiordan MA, Borawski EA,
McConnell J, Kern EO: Development and validation of a
Dorman K, Derbew M, Satterthwaite L, Woodrow S, Howard A,
questionnaire to assess carbohydrate and insulin-dosing
Reznick R, Dubrowski A: Addressing the severe shortage of
knowledge in youth with type 1 diabetes. Diabetes Care 2010:
healthcare providers in Ethiopia: Bench model teaching of
33(3): pp 457-462.
technical skills. Medical Education 2009: 43(7): pp 621-627.
Kuper A, Martimianakis MA, McNaughton N, Albert M, Hodges B:
Gagliardi AR, Perrier L, Webster F, Leslie K, Bell M, Levinson W,
Asking new questions with qualitative research: A reflection on
Rotstein O, Tourangeau A, Morrison L, Silver I, Straus SE:
AMEE 2009. Medical Teacher 2010: 32: pp 1-2.
Exploring mentorship as a strategy to build capacity for
knowledge translation research and practice: protocol for a
qualitative study. Implementation Science 2009: 4: p 55.
Lacasse M, Ratnapalan S: Teaching-skills training programs
for family medicine residents: Systematic review of formats,
content, and effects of existing programs. Canadian Family
Ginsburg S, Regehr G, Mylopoulos M: From behaviours to
Physician 2009: 55(9): pp 902-903.
attributions: Further concerns regarding the evaluation of
professionalism. Medical Education 2009: 43: pp 414-425.
Lacasse M, Routhier G, LeBlanc P, Th├йor├кt J, Glenn J,
Ratnapalan S: Teaching residents to teach: Do program
Green S, Grierson LE, Dubrowski A, Carnahan H: Motor
directors and trainees agree on format and content? Canadian
adaptation and manual transfer: Insight into the persistent
Medical Education Journal 2010: 1(1): pp e18-e28.
nature of sensorimotor representations. Brain and Cognition
2010: 72(3): pp 385-393.
Lovett M, Bremner R, Barr CL: Association of reading
disabilities with regions marked by acetylated H3 histones in
KIAA0319. American Journal of Medical Genetics Part B 2009:
153B: pp 447-462.
22
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Mehta SV, Al-Dhafian A, Schneeweiss S, Babyn P, Pirie J: Does
Silver I, Leslie K: Faculty development for continuing
online X-ray education help trainees in the pediatric emergency
interprofessional education and collaborative practice.
department? Open Medicine 2009; 3(3 Suppl.): p 57.
Journal of Continuing Education in the Health Professions
2009: 29(3): pp 1-6.
Mirfendereski M, Roth K, Fan B, Dubrowski A, Carnahan H,
Azarpazhooh A, Basrani B, Torneck CD, Friedman S: Technique
Valani R, Sriharan A, Scolnik D: Designing international health
acquisition in the use of two thermoplasticized root filling
electives using the CanMEDS core competencies. Medical
methods by inexperienced dental students: A microcomputed
Teacher 2009: 31(12): p 1097.
tomography analysis. Journal of Endodontics 2009: 35(11):
pp 1512-1517.
Valani R, Verma M, Sriharan A, Scolnik D: Enabling change
Rosenblum ND, Bazett-Jones D, OтАЩBrodovich H: A Scientist
emergency medicine elective. Israeli Journal of Emergency
Track Investigator Program to Support Early Career Outcomes
Medicine 2009: 9(2): pp 22-29.
in attitudes among medical students during a paediatric
for Clinician Scientists. Journal of Pediatrics 2009: 155(5):
pp 603-604.
Walsh CM, Ling SC, Wang CS, Carnahan H: Concurrent versus
terminal feedback: ItтАЩs better to wait! Academic Medicine
Ratnapalan S, Rayar MS, M Crawley M: Educational services
2009: 84(Suppl 10): pp S54-S57.
for hospitalized children. Paediatrics & Child Health 2009:
14(7): pp 433-443.
Xeroulis G, Dubrowski A, Leslie K: Simulation in laparoscopic
surgery: A concurrent validity study for FLS. Surgical Endoscopy
Rosenfield J: Commentary-interesting approach more research
2009: 23(1): pp 161-165.
needed. International Journal of the Creative Arts in
Interdisciplinary Practice (on-line). Issue 8, Fall 2009.
Book Chapters
Dubrowski A, MacRae H: Measurement of competence.
Szumacher E, Harnett N, Warner S, Kelly V, Danjoux C, Barker
In: Minimally Invasive Surgery Training: Theories, Methods,
R, Woo M, Mah K, Ackerman I, Dubrowski A, Rose S, Crook J:
Outcomes [Internet] (Park A, Klein RV, eds.). Washington:
Effectiveness of educational intervention on the congruence
Department of Health & Human Services (US), National
of prostate and rectal contouring as compared with a Gold
Institutes of Health, National Library of Medicine, January
Standard in three-dimensional radiotherapy for prostate.
2010. Available from: http://www.mastri.umm.edu/NIH-Book.
International Journal of Radiation Oncology Biology and
Physics 2009: May 19 [Epub ahead of print].
Dubrowski A, Carnahan H, Reznick R. Research in surgical
education: A primer. In: Key Topics in Surgical Research and
Methodology (Darzi A, Athanasiou T, Debas H, eds.). Springer,
New York, 2009.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 23
HIGHLIGHTS OF OTHER FORMS
OF EDUCATIONAL SCHOLARSHIP
Drs. Tina Martimianakis and Maria Mylopoulos contributed
Education scholarship can take many forms, including
Atelier тАУ Qualitative Research in Depth. This advanced four-day
the development or dissemination of knowledge related to
workshop familiarized participants with educational, cognitive
in the development and teaching of the 2010 Wilson Centre
faculty and student relations, student learning and teaching,
science, rhetorical and social science theories relevant to
curriculum and program development, assessment and program
educational research and provided skill building opportunities
evaluation, and educational policies, among other things.
for evolving theory-based qualitative educational research. Tina
Martimianakis developed and delivered with colleagues an
This section highlights forms of educational scholarship taking
invited pre-conference workshop for the Association for Medical
place in our Department, including promising new directions in
Education in Europe on qualitative methodology (with Ayelet
educational innovation, which have not been captured under
Kuper, Nancy McNaughton, Mathieu Albert and Sarah Whyte).
the sections of awards, grants and publications.
Dr. Ann Jeffries developed and delivered a series of education
Enhancing Educational Methods and Pedagogy
related workshops, including Enhancing Assessment and
Our Department has a dedicated group of educators with
Evaluation in Inter-Professional Education at the Association
expertise in educational methods and pedagogy. During the
of Medical Education in Europe (with B. Simmons and
past year, they have contributed to skill building in education
S. Wagner), Becoming a Successful Educator and Incorporating
within the department, the university and internationally.
International Medical Graduates into a Canadian Residency
Program at the Annual Conference of the Royal College of
Dr. Zia Bismilla delivered a number of presentations and
Physicians and surgeons of Canada (with A. Atkinson and
workshops on simulation and health professional assessment
R. Hilliard), and Moving Your Career Ahead as a Clinician-
at the Sickkids Learning Institute, the Wilson Centre, and the
Teacher/Educator for the Centre for Faculty Development
Pediatric Academic Society.
(with R. Hilliard and K. Leslie).
In April 2009, Dr. Adam Dubrowski led a group of specialists
Curriculum and Program Development
in education theory, simulation design and simulation-based
Educators in our Department focus a lot of their energy on
education and training to Addis Ababa University (AAU),
reviewing, revising and developing programming for all levels
Ethiopia to conduct a four-day course. Dr. Dubrowski also
of trainees that is grounded in the most up-to-date basic and
contributed to the development and delivery of the Simulation
clinical research and is developed, delivered and assessed
Research Refined: The Network of Excellence in Simulation
according to current educational theories and practices.
for Clinical Teaching and Learning (NESCTL) and the Wilson
Furthermore, members of our faculty are contributing to
Centre Atelier. This four-day intensive program in advanced
the development of educational programming and learning
simulation-based education research guided participants
standards and objectives at the university, national and even
through some of the most relevant theories of learning,
international level. The following are only some examples of
performance assessments and performance affecting factors.
activities that fall in this category:
24
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Dr. Shinya Ito, in collaboration with three institutions in Europe,
Dr. Gideon Koren has created and led a number of educational
is leading an international initiative involving 20 institutions
programs including the NIH-CIHR Summer Institute in Maternal-
with a plan to formulate a program for global training of
Fetal Pharmacology, a new model for Critical Appraisal rounds
paediatric clinical pharmacologists to improve paediatric drug
in clinical pharmacology and workshops on screening and
therapy. The proposal has received funding from the European
diagnosing of FASD.
Union. The development of the curriculum and innovative
learning environments, as well as the implementation of
the program, will evolve over the next five years.
Dr. Anu Wadhwa led an interprofessional team in the complete
restructuring, development and implementation of the
outpatient experience of the Infectious Diseases fellows. In
At the national level, Dr. Jay Rosenfield, through his position
addition to the тАШmedical expertтАЩ CanMEDS competency, this
as Co-Chair of the Task Force on Implementation Strategy,
new Continuity of Care curriculum has been designed to
Future of Medical Education in Canada, is coordinating a
specifically incorporate teaching an evaluation in the CanMED
process of curriculum renewal of undergraduate medical
тАШmanagerтАЩ competency. In addition, Dr. Wadhwa developed and
training across Canada.
presented a four-part interactive series to the Infectious
Within our Department, a number of educational innovations
skills in physician communication.
Diseases fellows, aimed at improving and evaluating their
and curricular changes were made last year that work to
enhance our training programs or educate families and
Educational Assessment and Evaluation
patients. For example, Dr. Susanne Benseler developed and
In the area of assessment and evaluation we have a growing
implemented the clinical research tools (CRT) curriculum for
focus on using existing modalities or developing new tools
paediatric and adult rheumatology fellows. Collaborating with
to assess learning of complex tasks, including specialized
AboutKids-Health, she also developed an online educational
procedures or working in teams.
tool for patients with CNS vasculitis and their families.
As part of her PhD thesis work, Dr. Catherine Walsh, Fellow
Dr. Anne Opavsky conceptualized, and oversaw the
in Gastroenterology, Hepatology and Nutrition, is currently
development and launch of e-fection, a quarterly newsletter
developing an evaluation tool for training in colonoscopy and
produced by the Division of Infectious Diseases to enhance
researching the process of teaching procedural skills, including
understanding and learning on topics related to prevention,
studies of optimal training of feedback to trainees.
diagnosis and management of infectious disease. E-fection
articles are contributed by members of the Division (including
Drs. Brian Simmons, Susan Wagner and Ann Jefferies are
staff, fellows and nurses) and designed for community and
evolving approaches for using the OSCE to assess CanMEDS
hospital-based physicians, fellows, residents, medical
competencies. Brian Simmons is also developing, with a
students, and other health care workers.
number of collaborators across the university, approaches
to assessing interprofessional education.
Dr. Simon Ling implemented a formal curriculum for fellows
in paediatric gastroenterology. The design of this curriculum
Dr. Kathryn Parker is leading a number of evaluation initiatives
was initiated by Nicola Jones and had input from all faculty
at the Learning Institute with hospital-wide focus. For example,
and fellows.
this past year Kathryn has evolved the Learning Institute
strategy map and balanced scorecard, led the development
of quality indicators for education, and developed a strategic
framework for evaluating organizational strategic change
and innovation.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 25
Division Head
Dr. Debra K. Katzman
Full-Time
Dr. Eudice Goldberg
Dr. Miriam Kaufman
Dr. Karen Leslie
Dr. Cathleen Steinegger
Part-Time
Dr. Miriam Rossi
Dr. Rahul Saxena
Dr. Ellie Vyver
Clinical Fellows
Dr. Ian Chen, DO
Dr. Herbert Joseph Bonifacio
Dr. Alene Toulany
Dr. Trish Tulloch
Dr. Asha Pemberton-Gaskin
Administrative Staff
Denise Ferreira
Melissa Keown
Burnett Wint
Division of Adolescent Medicine
The Division of Adolescent Medicine provides state-of-the-art,
The team continues to develop and customize new resources,
comprehensive specialty care to patients up to 18 years of age,
including colourful clinic posters and timelines to encourage
focusing its clinical activities in five programs: Eating Disorders,
patients, families and practitioners to begin preparing for
Good 2 Go, Substance Abuse, Young Families and SickKids
transition to adult care at an early age. Other resources include
Interprofessional Team for Youth (SITY). All of these are
the transition тАЬGetting Ready for Adult CareтАЭ booklet, transition
comprehensive and interdisciplinary programs with strong
readiness checklists, graduation certificates, transfer letters,
clinical, educational and research activities.
and the MyHealth Passport. For many of these resources,
Eating Disorders Program
customize the tools for their specific clinic population. For
The Eating Disorders Program at SickKids continues to provide
example, the timeline has been customized for more than
interdisciplinary, family-based treatment to children and
nine hospital programs and the MyHealth Passport for more
adolescents with a wide range of eating disorders and complex
than 40 clinics/conditions.
hospital programs work closely with the Good 2 Go team to
eating problems. Clinical services range from consultation and
outpatient programs to intensive day hospital and in-patient
The team also works directly with many teams throughout the
services. Multifamily group therapy continues to be a vital
hospital to plan and implement patient/family education days
component of eating disorder care and allows for families to
and transfer clinics (an opportunity for patients to meet adult
receive comprehensive treatment and support in a timely
providers). Direct patient care is provided for especially complex
manner. The Eating Disorders Program provides training in the
transition cases referred to the program from throughout the
care of these complex patients to medical students, paediatric
hospital through the Transitions Treatment Clinic.
residents and subspecialty residents, as well as to a wide
range of interdisciplinary trainees. Additionally, the Ontario
The Good 2 Go team held the second annual, hospital-wide
Community Outreach Program (a collaborative of SickKids,
EmployABLE event in collaboration with OntarioтАЩs Mazemaster/
University Health Network and the MOHLTC) trains health care
Youth@bilities at the hospital in May 2010. This full-day event
professionals around the province to assess and treat patients
drew over 100 youth, and was designed to motivate adolescents
with eating disorders, which allows many families to receive
with chronic health conditions to develop skills for successful
excellent treatment in their home community. The Eating
job search. This year the event included motivational speakers,
Disorders Program has an active research agenda. Our primary
opportunities to learn interview skills, a forum for networking
areas of research include the biological underpinnings of
with potential employers and a variety of discussions on
eating disorders, medical and psychological interventions
accommodations in the workplace as they relate to medical
for eating disorders and determinants of outcomes.
conditions. Negotiations with Mazemaster/Youth@bilities have
also started to develop a monthly career clinic designed to
Good 2 Go Transition Program
provide individual support and vocational counselling for youth
The goal of the Good 2 Go Transition Program is to prepare all
with special health care needs.
youth with chronic health conditions to leave SickKids by the
age of 18 years with the necessary skills and knowledge to
The team continues to seek and receive outside funding for
advocate for themselves or through others, maintain health-
specific initiatives and research projects. Manulife Financial
promoting behaviours and utilize adult health care services
funded a project on clinical pathways (i.e., guidelines to
appropriately and successfully. Due to an increase in the
facilitate patient transitions designed to be used by health
volume of clinics requesting assistance in developing transition
care providers at clinic visits throughout SickKids) is being
initiatives, a Clinical Nurse Specialist joined the team in
developed in conjunction with IT services. The team received
August 2009. In addition, a new team lead joined the
funding from the Kidney Foundation of Canada to work
Good 2 Go Transition Program in June 2010.
collaboratively with staff from the University Health Network
to explore the best way to modify an existing adult self-
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 27
management program for youth who have chronic health
and high school students, teachers, group home staff,
conditions. Over the past year, focus groups and initial
probation officers and parent groups. The program is shifting
self-management group sessions took place and the
the focus of the outreach education efforts to target those
intervention will be expanded to include patients with diabetes.
professionals working with adolescents in order to provide them
with the knowledge and skills with which to enhance the work
The team collaborates with many programs/clinics within the
they currently do with this complex patient population.
hospital and with community partners (e.g. Holland Bloorview,
Mazemaster/Youth@bilities). Additionally, they offer
Integral to the clinical work is the ongoing pursuit to develop
supervision and mentorship to several interdisciplinary trainees
new knowledge about how best to deliver care to adolescent
in the area of transition. This year a nursing mastersтАЩ and
and their families. These objectives are pursued in research
social work mastersтАЩ student and the Adolescent Medicine
projects that look at evaluation of family-based programs and
Fellows will be working closely with the team in various clinical
program outcomes in this high-risk population.
and research projects. Additional educational efforts include
an introduction to transition during SickKidsтАЩ Nursing
SickKids Inter-professional Team for Youth: SITY
Orientation Sessions (led by Good 2 Go Staff), and rounds/
The SickKids Interprofessional Team for Youth (SITY) provides
training of psychology and social work interns.
youth with access to expert adolescent health care services
The upcoming year (2010-2011) marks the fifth year of the
providers. The team addresses a wide spectrum of concerns
Good 2 Go Transition Program and a celebration event will
including illness-specific issues for youth with chronic health
be planned to recognize the efforts of staff throughout the
conditions, the identification and reduction of high-risk health
from our team of highly skilled interprofessional healthcare
hospital and collaborative adult programs who serve as
behaviours and advocacy efforts. Increasingly, the SITY team
champions promoting transition initiatives.
is being consulted regarding youth with clinical conditions that
are considered diagnostic dilemmas.
Substance Abuse Program
The Substance Abuse Program continues to provide clinical
SITY also provides clinical services in collaboration with renal,
assessment and ongoing treatment to adolescents and their
cardiac and lung transplant programs, the HIV and SLE clinics
families who are experiencing difficulties as a result of alcohol
and through in-patient consultations. The clinic has been
and other substance abuse. Services provided include
actively involved with the newly developed STOMP clinic. SITY
outpatient counselling, comprehensive health assessment
has an established link to the Substance Abuse Program,
and follow-up, intensive day treatment, as well as parent
addressing the complex medical needs of these adolescents.
support and counselling.
In addition, SITY continues to build partnerships with local
The program provides education and training to a variety of
agencies such as Toronto ChildrenтАЩs Aid Society and the
learners, including medical students, core and subspecialty
Triangle School Program of the Toronto District School Board
paediatric trainees, child and youth counselor and nurse
in an effort to enable youth in the downtown core to access
practitioner students to name a few. Members of the program
health information and necessary health services otherwise
are also engaged in the provision of continuing education locally,
unavailable to them.
nationally and internationally. This ranges from engaging
paediatric residents through the use of role playing, to
This year marks the debut of the Continuity of Care Clinic (C3)
presenting to advanced practice nurses about the adolescent
for Adolescent Medicine subspecialty residents focusing on
brain and the effects of substance abuse. Outreach community
continuity of care for medical services, ongoing counselling to
education has included presentations and sessions with middle
youth, and enhancing the ability for successful interventions.
28
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Finally, this year, representatives of the SITY team will be
The Young Families Program is a designated site for the new
influencing adolescent health at the international level by providing
Social Paediatrics Program where medical students and
a five-day curriculum to student health advisors in Singapore.
residents learn to integrate the principles of the social
determinates of health to a vulnerable high-risk population.
The Young Families Program
In addition, members of YFP are working with the social
The Young Families Program (YFP) focuses on providing health
paediatrics team to integrate innovative models of health care
care, advocacy, support and education to high-risk adolescent
into community sites such as schools and child protection clinics.
parents and their children. The YFP collaborates with several
agencies including prenatal homes and child protection
Our Team
agencies. In particular, the YFP provides a consultation clinic
The Division of Adolescent Medicine at SickKids is the largest
alongside St. MichaelтАЩs Hospital Inner City team at The June
division of adolescent medicine in Canada, with a diverse
Callwood Centre for Teenagers and provides clinical care,
interprofessional clinical team and staff. Members of the
education and policy recommendations.
interprofessional team provide quality care to adolescents
and their families in a teen-friendly setting. This integrated
The YFP, in collaboration with Suspected Child Abuse and
approach is essential to promoting comprehensive health
Neglect (SCAN) team, has created the High Risk Project - a
care to adolescents and their families.
clinical research project that has resulted in a developmentallyappropriate standardized approach to clinical assessment,
Research
education and ongoing care of patients. The team is embarking
The Division of Adolescent Medicine has integrated research
on the intervention phase with an emphasis on maternal and
into a more fundamental and focused component of its work.
infant mental health and child-parent relationships. The YFP
Key research areas include biological studies of eating
has developed a collaboration with the Infant Mental Health
disorders and their medical consequences with specific
Team in the Department of Psychiatry, meeting the needs of
emphasis on osteoporosis and brain structure and function,
the most vulnerable at-risk youth and their children.
epidemiology of early-onset eating disorders, evaluation of
family-based treatments for adolescents with eating disorders;
The interprofessional team members continue to provide
approaches in understanding and evaluating the process of
resources and education to health professionals in a variety
health care transition for youth with special health care needs;
of settings through structured clinical experiences, conference
and the evaluation of faculty development and mentoring.
presentations and committee participation and affiliation with
Other areas of research include the Young FamiliesтАЩ High-Risk
several faculties at the University of Toronto. Teaching of all
Project that is geared to help understand the medical and
disciplines is occurring in the clinic setting, and increasingly
psychological characteristics of this high-risk population.
in the community sites where high-risk youth are presently
Several research projects have been undertaken by the
underserviced. Recent collaborative research relationships
Substance Abuse Program including the GAIN-Short Screener
with faculty members from the Lawrence S. Bloomberg Faculty
Project, Strengthening Families Project, which is a collaborative
of Nursing, University of Toronto, will support expansion of our
project with Health Canada looking at long-term outcomes
research capacity in the field of high-risk adolescent parents
of patients in day treatment, and a quality improvement project
and their children.
evaluating parentsтАЩ educational needs in an effort to develop
parent psychoeducation program on adolescent substance
use and abuse.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 29
Teaching and Education
In January 2009, The University of Toronto subspecialty
The Division provides training opportunities to a diverse group
training program in adolescent medicine was accredited by
of learners including undergraduate and postgraduate medical
the Royal College of Physicians and Surgeons of Canada. To
trainees from medicine (Paediatrics, Psychiatry and Family
date, it is one of four in adolescent medicine in Canada to be
Medicine), nursing, psychology, social work, nutrition, art
recognized by the college. The program underwent an interval
therapy and child youth counsellor training programs. Members
review in September 2010. Members of the Division have
of the Division continue to make important educational
taken a leadership role in the development of the first RCPSC
contributions to local, provincial, national and international
subspecialty examination in adolescent medicine. The first
committees, and have leadership roles at the Centre for
examination was offered in September 2010. The first SickKids
Faculty Development,the Royal College of Physicians and
fellows to complete the newly accredited subspecialty training
Surgeons of Canada, Canadian Paediatric Society Adolescent
program will graduate in summer of 2011.
Health Committee, American Academy of Pediatrics Section
on Adolescent Medicine, the Society for Adolescent Medicine,
the Canadian Association for Adolescent Health, the Canadian
This past year, the Division hosted the first FellowтАЩs Day,
тАЬExploring Adolescent Health Together and Globally.тАЭ The goal of
Association for Medical Education and the Academy for
this one-day educational conference was to bring together past
Eating Disorders.
and current SickKidsтАЩ fellows from around the world to share
The Division of Adolescent Medicine has played an integral
and their families. Approximately 30 fellows participated in this
role in the social paediatrics initiative at SickKids. Dr. Eudice
exciting day, representing Barbados, Canada, Costa Rico, India,
Goldberg represents the lead for Adolescent Medicine and
Israel, Jamaica, New Zealand, Saudi Arabia, and Turkey.
successes and challenges in the work we do with adolescents
has participated in community initiatives with Dr. Lee Ford
Jones and others, representing the тАЬyouth componentтАЭ of
The Division has been involved in developing an adolescent
the program. Initiatives underway include looking at violence
medicine program with the Hamad Medical Corporation in
and mental health needs in the Jane-Finch corridor and the
Qatar. Until now, paediatrics in Qatar only included children
development of school-based clinics in Ontario. In addition,
up to the age of 14; so this will be a new subspecialty in the
the YFP is a designated site for social paediatrics electives.
region. An interprofessional group within the Division at SickKids
The Division of Adolescent Medicine continues to play an
has been meeting internally and also by teleconference with
integral role at SickKids and the University of Toronto in the
a group in Qatar. The Division will send a physician and nurse
area of youth advocacy.
practitioner to Qatar for an in-depth needs assessment and
other teams will follow up with action plans.
The Division launched its quarterly newsletter Adolessence
which provides information about divisional programs,
services and events. It also offers updates on events involving
the Division. The newsletter has been widely disseminated
in an effort to inform our colleagues throughout the Hospital
about the many initiatives happening in the Division of
Adolescent Medicine.
30
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Honours and Awards
Kaufman M: Recipient of the Arbor Award, University of Toronto.
Gagliardi AR, Perrier L, Webster F, Leslie K, Bell M, Levinson W,
Rotstein O, Tourangeau A, Morrison L, Silver I, Straus SE:
Exploring mentorship as a strategy to build capacity for
Publications
knowledge translation research and practice: protocol for a
Anthony SJ, Kaufman M, Drabble A, Seifert-Hansen M,
qualitative study. Implementation Science 2009: 4: p 55.
Dipchand Al, Martin K: Perceptions of transitional care needs
and experiences in pediatric heart transplant recipients.
American Journal of Transplantation 2009: 9(3): pp 614-619.
Goldberg E, Millson P, Rivers S, Jeanneret Manning S, Leslie K,
Read S, Shipley C, Victor CJ: An HIV risk reduction intervention
for incarcerated youth: A randomized controlled trial. Journal
Areemit R, Katzman DK, Pinhas L, Kaufman M: The experience
of Adolescent Health 2009: 44(2): pp 136-145.
of siblings of adolescents with eating disorders. Journal of
Adolescent Health 2010: 46: pp 569-576.
Kanbur N ├Ц, Goldberg E, Pinhas L, Hamilton R, Clegg R,
Katzman DK: Second-degree atrioventricular block (Mobitz
Baker L, Reeves S, Egan-Lee E, Leslie K, Silver I: The ties that
Type I) in an adolescent with anorexia nervosa: Intrinsic or
bind: A network approach to creating a program in faculty
acquired conduction abnormality. International Journal of
development. Medical Education 2010: 44(2): pp 132-139.
Eating Disorders 2009: 42(6): pp 575-578.
Baker L, Egan-Lee E, Leslie K, Silver I, Reeves S: Exploring an
Kanbur N ├Ц, Pinhas L, Lorenzo A, Farhat W, Licht C,
IPE faculty development program using the 3-P model. Journal
Katzman DK: Nocturnal enuresis in adolescents with
of Interprofessional Care 2010: 24(5): pp 597-600.
anorexia nervosa: Prevalence, potential causes and
Bravender T, Bryant-Waugh R, Herzog D, Katzman D, Kriepe RD,
2010: March 30: [Epub ahead of print].
pathophysiology. International Journal of Eating Disorders
Lask B, Le Grange D, Lock J, Loeb KL, Marcus MD, Madden S,
Nicholls D, OтАЩToole J, Pinhas L, Rome E, Sokol-Burger M, Wallin
Katzman DK. Sexting: Keeping teens safe and responsible
U, Zucker N: Workgroup for Classification of Eating Disorders in
in a technologically savvy world. Paediatrics & Child Health
Children and Adolescents: Classification of eating disturbance
2010: 15 (1): pp 41-42.
in children and adolescents: Proposed changes for the DSM-V.
European Eating Disorders Review 2010: 18(2): pp 79-89.
Katzman DK, Taddeo D: Emergency contraception.
Adolescent Health Committee, Canadian Paediatrics Society.
Findlay S, Pinzon J, Taddeo D, Katzman DK: Assessment
August 2009 (http://www.caringforkids.cps.ca/teenhealth/
and management of children and adolescents with anorexia
EmergencyContraception.htm at the www.caringforkids.cps.ca).
nervosa тАУ a family-based approach. Paediatrics & Child Health
2010: 15(1): pp 31-35.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 31
Kaufman M, Shemesh E, Benton T: The adolescent
Funding
transplant recipient. Pediatric Clinics of North America 2010:
Advancing faculty development: A systematic review.
57(2): pp 575-92.
Reeves S, Leslie K, Egan-Lee E, Baker L Leslie K, Egan-Lee E,
Baker L. Royal College of Physicians and Surgeons of Canada
Lee A, Kaufman M: In my life. The Lancet Online,
($4,950 2010)
December 2009. Accessible at: http://www.thelancet.com/
themed-disability-lee.
Bulimic eating disorders in children and adolescents: Canadian
McDonagh J, Kaufman M: The challenging adolescent.
Boachie A, Crosby R, Katzman DK. Psychiatric Endowment
Journal of Rheumatology 2009: 48(8): pp 872-875.
Fund at SickKids ($24,000 2007-2009)
Paediatric Surveillance Program (CPSP). Pinhas L, Heinmaa M,
McDonagh J, Kaufman M: Transition from pediatric to adult
Development and testing of a self-management program
care after solid organ transplantation: Current Opinions in
for youth post-kidney transplant: A pediatric and adult care
Organ Transplantation 2009. 14: pp 526-532.
collaboration. Dettmer E, Cullen-Dean G, DтАЩAgostino N,
Kaufman M, Lorber S, Mitchell M, Schiff J, Pool R.
Silver I, Leslie K: Faculty development for continuing
Kidney Foundation of Canada ($85,134 2008-2010)
interprofessional education and collaborative practice.
Journal of Continuing Education in the Health Professions
Development of specialized transition program for HIV+
2009: 29(3): pp 1-6.
patients. Gilead Foundation ($24,000 2009)
Books and Book Chapters
Early-onset eating disorders тАУ a cohort study. Toulnay A,
Katzman DK, Kanbur N ├Ц, Steinegger C. Medical screening
Pinhas L, Elliott A, Pinzon J, Katzman DK. TraineeтАЩs Start-up
and management of eating disorders in adolescents. In: The
Fund ($3,000 2008-2009)
Oxford Handbook of Eating Disorders (Agras WS, ed.). Oxford
Library of Psychology, Oxford University Press, Inc., 2010.
Effects of anorexia nervosa on peak bone mass. Klibanski A,
Katzman DK, Misra M, Herzog D, Levitsky L. National
Institutes of Health/National Institute of Diabetes and
Digestive and Kidney Diseases ($3,801,660 2003-2010)
32
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Exploring mentorship as a strategy to build capacity for
Mobile phone-based self-management system for adolescents
knowledge translation research and practice. Gagliardi AR,
with Type I Diabetes Mellitus: A home-based self-care tool that
Bell M, Leslie K, Levinson W, Straus S, Morrison L, Tourangeau A,
links the client and family with their health care team. Cafazzo
Rotstein O, Silver I. Canadian Institutes of Health Research
J, Palmert M, Katzman DK, Leonard K, Casseleman M. Care to
($83,765 2009-2010)
Know Centre, Saint Elizabeth Health Care ($119,000
2009-2010)
Faculty development to support capacity building for Interprofessional education. Leslie K. Reeves S, Silver I, Merkley J,
Personality, body image, and disordered eating in pediatric
Richardson D, Wagner S, Andrews M, Kwan D. Ministry of
heart and lung transplant recipients. Pollock-BarZiv SM,
Health and Long-Term Care ($310,000 2008-2009)
Anthony S, Dipchand A, Kaufman M, Solomon M. International
Society for Heart and Lung Transplantation ($12,000 2009)
Family therapy and Fluoxetine in the treatment of adolescent
anorexia nervosa. Agras S, Brandt H, Halmi K, Johnson C,
Preparation for a career in academic medicine: Understanding
Kaye W, Wilfley D, Woodside B, Pinhas L, Katzman DK.
the process of peer-group mentoring for postgraduate trainees.
National Institute of Mental Health ($6,250,000 2007-2012)
Leslie K, Breakey V, Lingard L. Education Development Fund
($5,280 2009)
Frequency and pathophysiology of nocturnal enuresis in
adolescents with anorexia nervosa. Kanbur NO, Pinhas L,
Risperidone for adolescent anorexia nervosa: A pilot project.
Lorenzo A, Farhat W, Licht C, Katzman DK. TraineeтАЩs Start-up
Pinhas L, Bondy S, Lau E, Steinegger C , Katzman D, Woodside
Fund ($3,000 2008-2009)
B. SickKids Psychiatry Endowment Fund Grant ($24,874
2009 - 2010)
Further development of the MyHealth Passport. Good 2 Go
Transition Program. John Deere Foundation ($50,000
2008-2013)
Strengthening families for parents and youth 12-16. Goldberg E.
Health Canada Drug Strategy Community Initiatives Fund
($309,210 2009-2012)
Leadership: тАЬCreating Communities of Practice for Interprofessional Collaboration (IPC) in TorontoтАЭ. Kwan D, Leslie K,
The development and evaluation of an internet site to enhance
Lieff S, Nasmith L, Oandasan I, Reeves S, Silver I. Ministry of
the transfer and transition from pediatric to adult-focuses
Health and Long-Term Care Interprofessional, Mentorship,
cardiology care. Good-2-Go Transition Program. Labatt Heart
Preceptorship, Leadership and Coaching Fund ($1,200,000
Centre Innovation Fund ($25,000 2009-2011)
2007-2009)
Utilizing teaching evaluations to promote faculty development
in teaching. Leslie K, Lieff S, Pittini R, Reeves S, Schrieber M.
Undergraduate Medical Education Curriculum Renewal Fund
($19,630 2009)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 33
Division Head
Dr. Andrew Redington
Full-Time
Dr. Lee Benson
Dr. Tim Bradley
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Rajiv Chaturvedi
Anne Dipchand
Mark Friedberg
Fraser Golding
Gil Gross
Lars Grosse-Wortmann
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Robert Hamilton
Edgar Jaeggi
Paul Kantor
Joel Kirsh
Kyong-Jin Lee
Brian McCrindle
Dr.
Dr.
Dr.
Dr.
Luc Mertens
Seema Mital
Jennifer Russell
Elizabeth Stephenson
Part-Time
Dr. Claudia Almeida
Dr. Jack Colman
Dr. Rejane Dillenburg
Dr. Ra Han
Dr. Alexandra Jevremovic
Division of Cardiology
Divisional Overview
The cardiovascular research focus within the SickKids Research
The Division of Cardiology was formally established in the 1940s
Institute has made fundamental contributions to our understanding
and is now one of the largest and most successful in the world.
of the cellular biology and molecular genetics of pulmonary
Its philosophy has remained unchanged since its inception over
vascular bed, with recent diversification to include the study of
60 years ago: to provide the highest quality care in an evidence-
the fetal myocyte, detailed study of the intercellular structure of
based environment of clinical innovation and scientific discovery.
the heart and vessels, electrophysiology of the developing heart
The Division is not only performing at the highest clinical
and immunology of cardiac transplantation. High-quality basic
standard, but is now better positioned to drive innovation and
and translational research, with an emphasis on direct clinical
scientific discovery than at any other time in its history.
applicability, will continue to form the bedrock of our academic
program. As an example, the biology of a new technique, remote
While the Division is an integral part of the Department of
ischemic preconditioning, has been explored and translated to
Paediatrics, it also forms a key part of the Labatt Family Heart
clinical trials here at SickKids. The heart centre is making a
Centre, which was officially opened two years ago. Incorporating
major investment in the development of biobanking facility in
the Division of Cardiology, the Division of Cardiac Surgery, the
which DNA and tissue samples will be held for future fundamental,
Division of Cardiac Critical Care and The Toronto Congenital
translational and clinical research investigations. Aside from this
Cardiac Centre for Adults, the heart centre is already one of
thematic funding, the heart centre supports many proposals for
the best organized and cohesive in the world. However, there is
clinical innovation and seed-funding for scientific programs via
much more investment and development required before it will
its endowment, with the expectation that patient and family
have reached its goals. Nonetheless, over the past decade,
satisfaction will improve and the quality of research and its
the divisional activities, in close collaboration with surgical and
ability to garner external peer-reviewed funding will be enhanced.
intensive care colleagues and all the other members of the heart
centre, have contributed to our markedly improved preoperative
The Royal College-accredited Paediatric Cardiology Training
diagnosis and postoperative outcomes for children undergoing
Program is the largest in Canada and one of the largest and
cardiac surgery. In addition, our activities have led the field in
most sought after in North America. As such, its fellows have
development of therapeutic catheter techniques, made
populated cardiology groups throughout the world, many going
important contributions to our understanding of fetal cardiac
on to become leaders of our specialty.
medicine, established one of the largest paediatric cardiac
transplantation centres worldwide, and won international
The single most important development of the last decade,
recognition for contributions in the field of epidemiology of
however, has been the establishment of the Labatt Family
acquired and congenital heart disease and surgical outcomes.
Heart Centre. Following a series of important internal initiatives,
Each of these areas has provided the substrate for the large
the extraordinary generosity of the Labatt family has funded
clinical research output of the Division which is underpinned
the redevelopment and future activities of the heart centre
by a world class laboratory science program. One of the recent
at SickKids.
exciting clinical developments was the commissioning of an
integrated suite of catheter laboratories and magnetic resonance
scanning facilities. This unique fusion will allow simultaneous
multi-mode research, investigation and treatment, setting the
scene for MRI-guided interventional procedures and physiologic
measurements in children.
Dr.
Dr.
Dr.
Dr.
Dr.
Anilkumar Menon
Tapas Mondal
Norman Musewe
Lynne Nield
Kambiz Norozi
Dr.
Dr.
Dr.
Dr.
Dr.
Erwin Oechslin
Ralf Fauch
Rachel Wald
Roxanne Walker
Eval Welisch
Adjunct
Dr. Fred Keeley
Cross-Appointees
Dr. Desmond Bohn
Dr. Sarah Bowdin
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Tilman Humpl
Afrothite Kotsakis
Renee Sananes
Steven Schwartz
Ben Sivarajan
Shi-Joon Yoo
Research Associates
Dr. Xiaojing Dai
Dr. Gustavo LaRotta
Dr. Jing Li
Publications
Barton M, Wasfy S, Dipchand AI, Hebert D, Ng V, Solomon M,
Al Dhahri KN, Potts JE, Chiu CC, Hamilton RM, Sanatani S:
Fecteau A, Stephen D, Allen U: Seven-valent pneumococcal
Are implantable loop recorders useful in detecting arrhythmias
conjugate vaccine in pediatric solid organ transplant recipients:
in children with unexplained syncope? Pacing and Clinical
a prospective study of safety and immunogenicity. The Pediatric
Electrophysiology 2009: 32: pp 1422-1427.
Infectious Diseases Journal 2009: 28(8): pp 688-692
Allen U, Barton M, Beyene J, Hu P, Khodai-booran N,
Bauch A, Lee KJ, Yoo SJ: Complete congenital obstruction
Hebert D, Dipchand A, Ng V, Solomon M, Grant D, Fecteau A,
of a scimitar vein in an infant with severe respiratory failure.
Ngan B, Read S, Zielenska M, Weitzan S: Gene expression
Cardiology in the Young 2009: 19(5): pp 524-526.
using microarrays in transplant recipients at risk of EBV
lymphoproliferation after organ transplantation: Preliminary
Boshoff D, Brown S, DeGiovanni J, Stumper O, Wright J,
proof-of-concept. Pediatric Transplantation 2009: 13(8):
Mertens L, Gewillig M: Percutaneous management of a fontan
pp 990-998.
fenestration: in search for the ideal restriction-occlusion
Apitz C, Reyes J, Humpl T, Redington AN: Pharmacokinetic
75 (1): pp 60-65.
device. Cathererization and Cardiovascular Inverventions 2010:
and hemodynamic responses to oral Sildenafil during invasive
testing in children with pulmonary hypertension. Journal of
Botker HE, Kharbanda R, Schmidt MR, Bottcher M, Kaltoft AK,
American College of Cardiology 2010: 55(14): pp 1456-1462.
Terkelsen CJ, Munk K, Anderson NH, Hansen TM, Trautner S,
Lassen JF, Christiansen EH, Krusell LR, Kristensen SD,
Thuesen L, Nielsen SS, Rehling M, Sorensen HT, Redington AN,
Apitz C, Webb GD, Redington A: Tetralogy of Fallot.
Neilseu TT: Remote ischaemic conditioning before hospital
Lancet 2009: 374(9699): pp 1462-1471.
admission, as a complement to angioplasty, and effect on
Asoh K, Hickey E, Dorostkar PC, Chaturvedi RR, van Arsdell G,
myocardial salvage in patients with acute myocardial infarction:
Humpl T, Benson LN: Outcomes of emergent cardiac
A randomized trial. Lancet 2010: 375(9716): pp 727-734.
catheterization following pediatric cardiac surgery. Catheter
Bradley TJ, Potts JE, Shoo KL, Potts MT, DeSouza A, Sandor
Cardiovascular Intervention 2009: 73: pp 933-940.
GGS: Early changes in the biophysical properties of the aorta
Asoh K, Walsh M, Hickey E, Nagiub M, Chaturvedi R, Lee KJ,
in pre-adolescent children born small for gestational age.
Benson LN: Percutaneous pulmonary valve implantation with
Journal of Pediatrics 2010: 156(3): pp 388-392.
bioprosthetic valves. European Heart Journal 2010: 31(11):
pp 1404-1409.
Buffo-Sequeira I, Kirsh JA, Hamilton RM, Russell JL, Gross GJ:
Barnett CP, Jaeggi E, Han RK, Nevo O, Keating S, Shannon P,
arrhythmogenic right ventricular cardiomyopathy. American
Bitnun A, Chitayat D: Unusual cardiac presentation of
Journal of Cardiology 2009: 104: pp 411-413.
Utility of exercise testing in children and teenagers with
congenital cytomegalovirus infection. Ultrasound in Obstetrics
and Gynecology 2010: 35: pp 119-120.
Clinical Fellows
Dr. Arvin Abadilla
Dr. Nauman Ahmad
Dr. Majied Alariefy
Dr. Mohammed Alghamdi
Dr. Jaime Alkon
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Tara Bharucha
Sharon Borik
Jennifer Conway
Andrea Dragulescu
Lucas Eastaugh
Tom Einbinder
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Yousef Etoom
Fernanda Fernandes
Alejandro Floh
Michael-Alice Moga
Thomas Moller
Mike Seed
Dr.
Dr.
Dr.
Dr.
Neil Seller
Mohit Singla
Dominik Stambach
Jonathan Windram
Subspecialty
Rresidents
Dr. Steven Greenway
Dr. Emilie Jean-St-Michel
Dr. Michael Mendelson
Dr. Varsha Thakur
Cadeiras M, Shahzad K, John MM , Gruber D, Bayern M,
Crystal MA, Al Najashi K, Williams WG, Redington AN,
Auerbach S, Sinha A, Latif F, Unniachan S, Memon S, Mital S,
Anderson RH: Inferior sinus venosus defect: Echocardiographic
Restaino S, Marboe CC, Addonizio LJ, Deng MC: Relationship
diagnosis and surgical approach. Journal of Thoracic
between a validated molecular cardiac transplant rejection
Cardiovascular Surgery 2009: 137(6): pp 1349-1355.
classifier and routine organ function parameters. Clinical
Dehghani P, Benson LN, Horlick EM: Transcatheter closure
Transplantation 2010: 24(3): pp 321-327.
of persistent left sided superior caval vein draining into left
Chaturvedi RR, Herron TJ, Simmons RM, Shore DS, Kumar P,
atrium - importance of balloon test occlusion. Journal of
Sethia B, Chua F, Kentish JC: Passive stiffness of myocardium
Invasive Cardiology 2009: 21: pp e122-e125.
from congenital heart disease. Implications for diastole and
cardiac dilatation Circulation 2010: 121(8): pp 979-988.
Dipchand A, Naftel D, Feingold B, Spicer R, Yung D, Kaufman B,
Kirklin J, Allain-Rooney T, Hsu D: Outcomes of children with
Cherney DZI, Miller JA, Scholey JW, Nasrallah R, Hebert RL,
cardiomyopathy listed for transplant: A multi-institutional study.
Curtis J, Dekker MG, Slorach C, Sochett EB, Bradley TJ:
Journal of Heart and Lung Transplantation 2009: 28(12):
Renal hyperfiltration is a determinant of endothelial function
pp 1312-1321.
responses to Cyclooxygenase 2 Inhibition in Type 1 Diabetes.
Dipchand AI, Pollock BarZiv SM, Manlhiot C, West LJ,
Diabetes Care 2010: 33(6): pp 1344-1346.
VanderVliet M, McCrindle BW: Equivalent outcomes for
Cherney DZI, Reich HN, Miller JA, Lai V, Zinman B, Dekker MG,
pediatric heart transplantation recipients ABO-blood group
Bradley TJ, Scholey JW, Sochett EB: Age is a determinant
incompatible versus ABO-compatible. American Journal
of acute hemodynamic responses to hyperglycemia and
of Transplantation 2009: 9: pp 1-9.
angiotensin ii in humans with uncomplicated Type 1 Diabetes
Docx M, Gewillig M, Simons A, Vandenberghe P, Weyler J,
Mellitus. American Journal of Physiology тАУ Regulatory,
Integrative and Comparative Physiology 2010: 199(1):
Ramet J, Mertens L: Pericardial effusions in adolescent
R206-R214.
girls with anorexia nervosa: Clinical course and risk factors.
Eating Disorders 2010: 18(3): pp 218-225.
Cherney DZI, Sochett EB, Lai V, Dekker MG, Slorach C,
Scholey JW, Bradley TJ: Renal hyperfiltration and arterial
Docx M, Vandenberghe P, Maleux, G, Gewillig, M, Mertens L:
stiffness in humans with uncomplicated Type 1 Diabetes
Severe hypertension due to renal polar artery stenosis in
Mellitus. Diabetes Care 2010: June 28 [Epub ahead of print].
an adolescent treated with coil embolization. Paediatric
Radiology 2009: 39: pp 1234-1237.
Clarizia NA, Chahal N, Manlhiot C, Kilburn J, Redington AN,
McCrindle BW: Transition to adult health care for adolescents
Draper DE, Giddins NG, McCort J, Gross GJ: Diagnostic
and young adults with congenital heart disease: perspectives
usefulness of graded exercise testing in pediatric
of the patient, parent and health care provider. Canadian
supraventricular tachycardia. Canadian Journal of
Journal of Cardiology 2009: 25(9): pp e317-e322.
Cardiology 2009: 25: pp 407- 410.
Research fellows
Dr. Kenji Baba
Dr. Mi-Young Cho
Dr Tadashi Waragai
Administrative Staff
Fatima Alas
Fe Berbano
Theresa Braggs
Sandra Brisebois
Paula Capela
Esther Delea
Pamela Hardy
Georgia Herdsman
Susan Jessop
Shelley Kahn-Fortes
Shloka Mirchandaney
Andrea Morris
Susan Morton
Eleanor Paulino
Ann Prosser
Rooma Vaidya
Shirley Wang
Eyskens B, Brown SC, Claus P, Dymarkowski S, Gewillig M,
Gross GJ: Management of Brugada syndrome in children.
Bogaert J, Mertens L: The influence of pulmonary regurgitation
Pediatric Health 2010: 4: pp 35-43.
on regional right ventricular function in children after
surgical repair of Tetralogy of Fallot. European Journal
of Echocardiography 2010: 11(4): pp 341-345.
Grosse-Wortmann L, Roche SL, Yoo SJ, Seed M , Kantor P:
Early changes in right ventricular function and their clinical
consequences in childhood and adolescent dilated cardiomyopathy.
Friedberg MK, Dubin AM, Van Hare GF, McDaniel GM,
Cardiology in the Young 2010: 20(4): pp 418-425.
Niksch A, Rosenthal DN: Acute effects of single-site pacing
from the left and right ventricle on ventricular function and
Grosse-Wortmann L, Rednington A: Doing the right thing at
ventricular-ventricular interactions in children with normal
the right time: Is there more to pulmonary valve replacement
hearts. Congenital Heart Disease 2009: 4: pp 356-361.
than meets the eye? European Heart Journal 2009: 30(17):
pp 2076-2078.
Friedberg MK, Dubin AM, Van Hare GF, McDaniel GM, Niksch A,
Rosenthal DN: Pacing-induced electromechanical ventricular
Hamilton R: Arrhythmogenic right ventricular cardiomyopathy.
dysynchrony does not acutely influence right ventricular
PACE 2009: 32: pp S44-S51.
function and global hemodynamics in children with normal
hearts. Journal of Cardiovascular Electrophysiology 2009: 20:
Hamilton RM, Azevedo ER: Sudden cardiac death in dilated
pp 539-544.
cardiomyopathies. PACE 2009: 32: pp S32-S40.
Friedberg MK, Silverman NH, Moon-Grady AJ, Tong E, Nourse J,
Hamilton R, Gray C, Belanger SA, Warren AE, Gow RM,
Sorenson B, Lee J, Hornberger LK: Prenatal detection of congenital
Sanatani S, Cote J-M, Lougheed J, Leblanc J, Martin S, Miles B,
heart disease. Journal of Pediatrics 2009: 155 pp 26-31.
Mitchell C, Gorman DA, Weiss M, Schachar R: Cardiac risk
assessment before the use of stimulant medications in
Gajarski R, Naftel D, Pahl E, Alejos J, Bennett Pearce F, Kirklin JK,
children and youth: A joint position statement by the Canadian
Zamberlan M, Dipchand A: Outcomes of pediatric patients with
Paediatric Society, the Canadian Cardiovascular Society and
hypertrophic cardiomyopathy listed for transplant. Journal of
the Canadian Academy of Child and Adolescent Psychiatry.
Heart and Lung Transplantation 2009: 28(12): pp 1329-1334.
Journal of the Canadian Academy of Child and Adolescent
Psychiatry 2009: 18: pp 349-355.
Gossett JG, Canter C, Zheng J, Schechtman K, Blume ED,
Rodgers S, Naftel DC, Kirklin JK, Scheel J, Fricker FJ, Kantor PF,
Hirji A, Bernasconi A, McCrindle BW, Dunn E, Gurofsky R,
Pahl E, and the Pediatric Heart Transplant Study Investigators:
Manlhiot C, Miner S, Kingdom J, Jaeggi E, Van Arsdell G,
Decline in rejection in the first year after pediatric cardiac
Nield L: Outcome of prenatally diagnoses Tetralogy of Fallot:
transplantation: A multi-institutional study. Journal of Heart
Implications for valve sparing repair versus transannular patch.
and Lung Transplantation 2010: 29(6): pp 625-632.
Canadian Journal of Cardiology 2010: 26: e1-e6.
Grattan MJ, McCrindle BW: Recurrent exacerbations of
Jaeggi E, Chitayat D, Taylor G: An unusual form of persistent
protein-losing enteropathy after initiation of growth hormone
fetal bradyarrhythmia: Atrial standstill associated with a
therapy in a fontan patient controlled with spironolactone.
complete loss of the atrial myocardium. Heart Rhythm 2009:
Congenital Heart Disease 2010: 592: pp 165-167.
6: pp 1370-1372.
38
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Jaeggi E, Golding F, Silverman E: Letter by Jaeggi et al
Kirk F, Naftel D, Hoffman T, Almond C, Boyle G, Caldwell RL,
regarding article тАЬPerinatal outcome of fetal atrioventricular
Kirklin JK, White K, Dipchand AI: Outcome of pediatric
block: One-hundred sixteen cases from a single institutionтАЭ.
patients with dilated cardiomyopathy listed for transplant:
Circulation 2009: 119: e539.
A multi-institutional study. The Journal of Heart and Lung
Transplantation 2009: 28(12): pp 1322-1328.
Jaeggi ET, Laskin CA, Hamilton RM, Kingdom J, Silverman ED:
The importance of maternal anti-Ro/SSA antibodies as
Krahn AD, Simpson CS, Parkash R, Yee R, Champagne J,
prognostic markers of the development of cardiac neonatal
Healey JS, Cameron D, Thibault B, Mangat I, Tung S, Sterns L,
lupus erythematosus: A prospective study of 186 antibody-
Birnie DH, Exner DV, Sivakumaran S, Davies T, Coutu B, Crystal
exposed fetuses and infants. Journal of the American College
E, Wolfe K, Verma A, Stephenson EA, Sanatani S, Gow R,
of Cardiology 2010: 55: pp 2778-2284.
Connors S, Paredes FA, Turabian M, Kus T, Essebag V,
Gardner M: Formation of a national network for rapid response
Kantor PF, Abraham JR, Dipchand AI, Benson LN, Redington
to device and lead advisories: The Canadian Heart Rhythm
AN: The impact of changing medical therapy on transplantation-
Society Device Advisory Committee. Canadian Journal of
free survival in paediatric dilated cardiomyopathy. Journal of
Cardiology 2009: 25(7): pp 403-405.
American College of Cardiology 2010: 55(13): pp 1377-1384.
Lampert R, Hayes DL, Annas GJ, Farley MA, Goldstein NE,
Kantor P, Mertens L: Heart failure in children. Part I: Clinical
Hamilton RM, Kay GN, Kramer DB, Mueller PS, Padeletti L,
evaluation, diagnostic testing, and initial medical management.
Pozuelo L, Schoenfeld MH, Vardas PE, Wiegand DL, Zellner R:
European Journal of Pediatrics 2010: 169(3): pp 269-279.
HRS Expert Consensus Statement on the Management of
Cardiovascular Implantable Electronic Devices (CIEDs) in
Kantor P, Mertens L: Heart failure in children. Part II: Current
patients nearing end of life or requesting withdrawal of
maintenance therapy and new therapeutic approaches.
therapy. Heart Rhythm 2010: 7: pp 1008-1026.
European Journal of Pediatrics 2010: 169(4): pp 403-410.
Lara-Corrales L, Mellerio JE, Martinez AE, Green A, Lucky AW,
Karagoz T, Asoh K, Hickey E, Chaturvedi R, Lee KJ, Nykanen D,
Azizkhan RG, Murrell DF, Agero AL, Kantor PF, Pope E: Dilated
Benson L: Balloon dilation of pulmonary valve stenosis in
cardiomyopathy in Epidermolysis bullosa: A retrospective,
infants less than 3 kg: A 20 year experience. Catheter and
multicenter study. Pediatric Dermatology 2010: 27(3): pp 238-243.
Cardiovascular Interventions 2009: 74(5): pp 753-761.
Lin AE, OтАЩBrien B, Demmer LA, Almeda KK, Blanco CL,
Karamlou T, McCrindle BW, Blackstone EH, Cai S, Jonas RA,
Glasow PF, Berul CI, Hamilton R, Micheil Innes A, Lauzon JL,
Bradley SM, Ashburn DA, Caldarone CA, Williams WG: Lesion-
Sol-Church K, Gripp KW: Prenatal features of Costello
specific outcomes in neonates undergoing congenital heart
syndrome: ultrasonographic findings and atrial tachycardia.
surgery are related to predominately patient and management
Prenatal Diagnosis 2009: 29: pp 682-690.
factors rather than institution or surgeon experience: A
Congenital Heart Surgeons Society Study. Journal of Thoracic
Lin YT, Manlhiot C, Ching JC, Han RK, Nield LE, Dillenburg R,
and Cardiovascular Surgery 2010: 139(3): pp 569-577.
Pepelassis D, Lai LS, Smythe JF, Chahal N, Yeung RSM,
Kharbanda R, Nielson TT, Redington A: Translation of remote
Disease in Ontario, Canada, 1995-2006. Paediatric
ischemic preconditioning. Lancet 2009: 31: 374(9700):
International 2010: January 26 [Epub ahead of print].
McCrindle BW. Epidemiological surveillance of Kawasaki
pp 1557-1565.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 39
Manlhiot C, Knezevich S, Radojewski E, Cullen-Dean G,
Moiduddin N, Asoh K, Slorach C, Benson LN, Friedberg MK:
Williams WG, McCrindle BW: Functional health status of
Effect of transcatheter pulmonary valve implantation on
adolescents after the Fontan procedure тАУ comparison with
short-term right ventricular function as determined by two-
their siblings. Canadian Journal of Cardiology 2009: 25(9):
dimensional speckle tracking strain and strain rate imaging.
e294-e300.
American Journal of Cardiology 2009: 104: pp 862-867.
Marcovecchio ML, Dunger DB, Dalton RN, Daneman D,
Moola F, McCrindle BW, Longmuir PE: Physical activity
Deanfield JE, Gray A, Jones TW, Neil A, Prevost AT, Acerini CL,
participation in youth with surgically corrected congenital
Amin R, Anand B, Barrett TG, Bradley TJ, Cameron FJ,
heart disease: Devising guidelines so Johnny can participate.
Celermajer DS, Cheetham TD, Cooper C, Couper J, Cotterill AM,
Paediatrics & Child Health 2009: 14(3): pp 167-170.
Davis EA, Donaghue KC, Dutta A, Edge JA, Mann NP,
Moudiotis C, Rayman G, Shield J, Thalange N, Wong TY:
Nasr A, McNamara P, Mertens L, Levin D, James A, Holtby H,
Adolescent type 1 Diabetes Cardio-renal Intervention Trial
Langer J: Is routine preoperative 2D echocardiography
(AdDIT). BMC Pediatrics 2009: 9: p 79.
necessary for infants with esophageal atresia, omphalocele,
or anorectal malformation? Journal of Pediatric Surgery 2010:
Marelli A, Beauchesne L, Mital S, Therrien J, Silversides CK:
45 (5): pp 876-879.
Canadian Cardiovascular Society 2009 Consensus Conference
on Management of Adults with Congenital Heart Disease:
Ohye RG, Sleeper LA, Mahony L, Newburger JW, Pearson GD,
Introduction. Canadian Journal of Cardiology 2010: 26(3):
Lu M, Goldberg CS, Tabbutt S, Frommelt PC, Ghanayem NS,
pp e65-e69.
Laussen PC, Rhodes JF, Lewis AB, Mital S, Ravishankar C,
Williams IA, Dunbar-Masterson C, Atz AM, Colan S, Minich LL,
McCrindle BW: Kawasaki disease: A childhood illness with
Pizarro C, Kanter KR, Jaggers J, Jacobs JP, Dent CK, Pike N,
important consequences into adulthood. Circulation 2009:
McCrindle BW, Virzi L, Gaynor JW, for the Pediatric Heart
120(1): pp 6-8.
Network Investigators: Outcomes of the Norwood Procedure
in Infants randomized to a modified Blalock-Taussig versus
Mehra M, Crespo-Leiro M, Dipchand A, Ensminger S, Hiemann N,
right ventricle-to-pulmonary artery shunt. New England Journal
Kobashigawa J, Madsen J, Parameshwar J, Starling R,
of Medicine 2010: 362(21): pp 1980-1992.
Uber P: New ISHLT cardiac allograft vasculopathy standardized
nomenclature: A common international definition will benefit
Ozawa A, Al-Radi O, MacDonald C, Tran KC, Sapra P, Davey LD,
heart transplant patients. The Journal of Heart and Lung
Chaturvedi RR, Caldarone CA, van Arsdell GS: The functional
Transplantation 2010: 29(7): pp 717-727.
intraoperative pulmonary blood flow study is a more sensitive
Minich LL, Atz AM, Colan SD, Sleeper LA, Mital S, Jaggers J,
and physiologic tolerance of ventricular septal defect closure
Margossian R, Prakash A, Li JS, Cohen MS, Lacro RV, Klein GL,
after complete unifocalization in patients with pulmonary
Hawkins JA: Partial and transitional atrioventricular septal
atresia, ventricular septal defect, and major aortopulmonary
defect outcomes: Does age at repair matter? Annals of
collaterals. Circulation 2009: 120(11 Suppl): S46-S52.
predictor than preoperative anatomy for right ventricular pressure
Thoracic Surgery 2010: 89(2): pp 530-536.
40
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Parkash R, Crystal E, Bashir J, Simpson C, Birnie D, Sterns L,
Sarnari R, Kamal RM, Friedberg MK, Silverman NH:
Exner D, Thibault B, Connors S, Healey J, Champagne J,
Doppler assessment of the ratio of the systolic to
Cameron J, Mangat I, Verma A, Wolfe K, Essebag V, Kus T,
AyalaтАРParedes F, Davies T, Sanatani S, Gow R, Coutu B,
diastolic duration in normal children: Relation to heart rate,
Sivakumaran S, Stephenson E, Krahn A: Complications
age and body surface area. Journal of the
associated with revision of sprint fidelis leads: Report from
the CHRS Device Advisory Committee. Circulation 2010:
American Society of Echocardiography 2009: 22: pp 928-932.
121(22): pp 2384-2387.
Saxena P, Newman MA, Shehatha JS, Redington AN,
Pollock-Barziv SM, Allain-Rooney T, Manlhiot C, Babu A, Nalli N,
Konstantinov IE: Remote ischemic conditioning: Evolution
McCrindle BW, Dipchand AI: Continuous infusion of thymoglobulin
of the concept, mechanisms, and clinical application.
for induction therapy in pediatric heart transplant recipients:
Journal of Cardiac Surgery 2009: 25(1): pp 127-134.
Experience and outcomes with a novel strategy for administration.
Pediatric Transplantation 2009: 13(5): pp 585-589.
Schwerzmann M, Salehian O, Harris L, Siu SC, Williams WG,
Quercia N, Somers GR, Halliday W, Kantor PF, Banwell B,
arrhythmias and sudden death in adults after a Mustard
Yoon G: Friedreich ataxia presenting as sudden cardiac death
operation for transposition of the great arteries. European
in childhood: Clinical, genetic and pathological correlation,
Heart Journal 2009: 30(15): pp 1873-1879.
Webb GD, Colman JM, Redington A, Silversides CK: Ventricular
with implications for genetic testing and counselling.
Neuromuscular Disorder 2010: 20(5): pp 340-342.
Schwieger-Briel A, Balma-Mena A, Ngan B, Dipchand A,
Roche SL, OтАЩSullivan J, Kantor PF: Hypertension after
immunosuppressed patients. Pediatric Dermatology 2010:
pediatric cardiac transplantation: Detection, etiology,
[Epub ahead of print].
Pope E: Trichodysplasia spinulosa тАУ a rare complication of
implications and management. Pediatric Transplantation
2010: 14(2): pp 159-168.
Seed M, Bradley T, Bourgeous J, Jaeggi E, Yoo SJ: Pulmonary
Saltzman AJ, Mancini-DiNardo D, Li C, Chung WK, Ho CY,
syndrome diagnosed with antenatal magnetic resonance
Hurst S, Wynn J, Care M, Hamilton RM, Seidman GW, Gorham J,
imaging. Pediatric Radiology 2009: 39: pp 747-749.
lymphangectasia associated with hypoplastic left heart
McDonough B, Sparks E, Seidman JG, Seidman CE, Rehm HL:
Short communication: The cardiac myosin binding protein C
Sequeira IB, Kirsh JA, Hamilton RM, Russell JL, Gross GJ:
Arg502Trp mutation: a common cause of hypertrophic
Utility of exercise testing in children and teenagers with
cardiomyopathy. Circulation Research 2010: 106: pp 1549-1552.
arrhythmogenic right ventricular cardiomyopathy. American
Journal of Cardiology 2009: 104: pp 411-413.
Sarkola T, Redington AN, Keeley F, Bradley TJ, Jaeggi ET:
Transcutaneous very high resolution ultrasound to quantify
Shimizu M, Tropak M, Diaz RJ, Suto F, Surendra H, KUzmin E,
arterial wall layers in muscular and elastic arteries: Validation
Li J, Gross G, Wilson GJ, Callahan JW, Redington AN: Transient
of a method. Atherosclerosis 2010: July 7 [Epub ahead of print].
limb ischemia remotely preconditions through a humoral
mechanism acting directly on the myocardium: Evidence
suggesting cross-species protection. Clinical Science (London)
2009: 117(5): pp 191-200.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 41
Shivananda S, Kirsh J, Whyte H, Muthalaly K, McNamara PJ:
Tanous D, Benson LN, Horlick EM: Coarctation of the aorta:
Impact of oxygen saturation targets and oxygen therapy during
Evaluation and management. Current Opinion in Cardiology
the transport of neonates with clinically suspected congenital
2009: 24(6): pp 509-515.
heart disease. Neonatology 2009: 97: pp 154-162.
Tanous D, Collins N, Dehghani P, Benson LN, Horlick EM:
Silversides CK, Kiess M, Beauchesne L, Bradley TJ, Connelly M,
Covered stents in the management of coarctation of the
Niwa K, Mulder B, Webb G, Colman J, Therrien J: Canadian
aorta in the adult: Initial results and 1-year angiographic and
Cardiovascular Society 2009 Consensus Conference on the
hemodynamic follow-up. International Journal of Cardiology
management of adults with congenital heart disease: Outflow
2010: 140(3): pp 287-295.
tract obstruction, coarctation of the aorta, tetralogy of Fallot,
Ebstein anomaly and MarfanтАЩs syndrome. Canadian Journal
of Cardiology 2010: 26(3): e80-e97.
Tobler D, Williams WG, Jegatheeswaran A, van Arsdell GS,
McCrindle BW, Greutmann M, Oechslin EN, Silversides CK:
Cardiac outcomes in young adult survivors of the arterial
Silversides CK, Marelli A, Beauchesne L, Dore A, Kiess M,
switch operation for transposition of the great arteries. Journal
Salehian O, Bradley TJ, Colman J, Connelly M, Harris L, Khiary P,
of the American College of Cardiology 2010: 56: pp 58-64.
Mital S, Niwa K, Oechslin E, Poirier N, Schwerzmann M, Taylor D,
Vonder Muhll I, Baumgartner H, Benson L, Celermajer D,
Tyrrell PN, Beyene J, McCrindle BW, Feldman BM, Silverman ED,
Greutmann M, Horlick E, Landzberg M, Meijboom F, Mulder B,
Bradley TJ: Rheumatic disease and carotid intima media
Warnes C, Webb G, Therrien J: Canadian Cardiovascular
thickness: A systematic review and meta-analysis.
Society 2009 Consensus Conference on the management
Arteriosclerosis, Thrombosis, and Vascular Biology 2010:
of adults with congenital heart disease: Executive summary.
30(5): pp 1014-1026.
Canadian Journal of Cardiology 2010: 26(3): pp 143-150.
Vezmar M, Chaturvedi R, Lee KJ, Almeida C, Manlhiot C,
Stephenson EA, Lu M, Berul CI, Etheridge SP, Idriss SF,
McCrindle BW, Horlick EM, Benson LN: Percurtaneous
Margossian R, Reed JH, Prakash A, Sleeper LA, Vetter VL,
pulmonary valve implantation in the young: 2 year follow-up.
Blaufox AD: Arrhythmias in a contemporary fontan cohort:
Journal of the American College of Cardiology тАУ Cardiovascular
Prevalence and clinical associations in a multicenter
Intervention 2010: 3(4): pp 439-448.
cross-sectional study. Journal of the American College
of Cardiology 2010: 56(11): pp 890-896.
Walsh MA, McCrindle BW, Dipchand AI, Manlhiot C, Hickey EJ,
Caldarone CA, Van Arsdell GS, Schwartz SM: Left ventricular
Stevens K, Hakonarson H, Kim C, Doevendans P, Mital S,
morphology influences mortality following the Norwood
Raue J, Glessner J, Coles JG, Moreno V, Granger A, Gruber SB,
operation. Heart 2009: 95(15): pp 1238-1244.
Gruber PJ: Common variation in ISL1 confers genetic
susceptibility for human congenital heart disease. PlosOne
2010: 5(5): p e10855.
Wan AW, Jevremovic A, Seda E, Tierney S, McCrindle BW,
Dunn E, Manlhiot C, Wald RM, Jaeggi ET, Nield LE: Comparison
of impact of prenatal versus postnatal diagnosis of congenitally
Sy RW, Hamilton R, Krahn AD: Neonatal Heart Block and Long
corrected transposition of the great arteries: A multicenter
QT Syndrome. Journal of Cardiovascular Electrophysiology
experience. The American Journal of Cardiology 2009: 104(9):
2010: April 28 [Epub ahead of print].
1276-1279.
42
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Warren A, Belanger S, Hamilton R, Gray C: Cardiac risk
Books and Book Chapters
assessment prior to the use of stimulant medications in
Benson L: The patent arterial duct. In: Paediatric Cardiology,
children and youth: A joint position statement by the Canadian
3rd Edition (Anderson RH, Baker EJ, Redington A, Rigby JML,
Pediatric Society, the Canadian Cardiovascular Society and
Penny D, Wernovsky G, eds.). Elsevier, London, England, 2009.
the Canadian Academy of Child and Adolescent Psychiatry.
Canadian Journal of Cardiology 2009: 25(11): pp 625-630.
Benson L, Yoo SJ, Al-Habshan F, Anderson RA: Ventricular
septal defect. In: Paediatric Cardiology, 3rd Edition (Anderson RH,
Williams RV, Ravishankar C, Zak V, Evans F, Atz AM, Border WL,
Baker EJ, Redington A, Rigby JML, Penny D, Wernovsky G, eds.).
Levine J, Li JS, Mahony L, Mital S, Pearson GD, Prakash A,
Elsevier, London, England, 2009.
Hsu DT: Pediatric Heart Network Infant Single Ventricle Trial:
Birth weight and prematurity in the screened population.
Conway J, Dipchand A: Optimization of outcomes for children
Congenital Heart Disease 2010: 5: pp 96-103.
after solid organ transplantation. In: Pediatric Clinics of North
America. Elsevier, London, England, 2010.
Wong DT, Grosse-Wortmann L, Yoo S-J: Transpleural pulmonaryto-systemic venous collaterals in a case with obstructed
Dipchand AI, Blume ED: Heart and Heart and Lung
scimitar vein. Pediatric Cardiology 2010: May 28 [Epub
Transplantation. In: Paediatric Cardiology, 3rd Edition
ahead of print].
(Anderson RH, Baker EJ, Redington A, Rigby JML, Penny D,
Wernovsky G, eds.). Elsevier, London, England, 2009.
Xin P, Zhu W, Li J, Ma S, Wang L, Liu M, Li J, Wei M,
Redington AN: Combined local ischemic postconditioning
Friedberg MK, Tay EL, Gatzoulis MA, Mertens L: The role
and remote preconditioning recapitulate the cardioprotective
of echocardiography in adult congenital heart disease. In:
effects of local ischemic preconditioning. American Journal of
European Society of Cardiology Textbook of Cardiovascular
Physiology тАУ Heart and Circulatory Physiology 2010: 298(6):
Imaging (Zamorano JL, Bax JJ, Radmakers F, Knuuti J, eds.).
pp H1819-H1831.
Springer-Verlag, London, 2009.
Yetman AT, McCrindle BW: The prevalence and clinical impact
Ganame J, Mertens L: Quantitative methods in echocardiography
of obesity in adults with Marfan syndrome.
- Advanced techniques in the assessment of ventricular
function. In: Echocardiography in Pediatric and Adult Congenital
Canadian Journal of Cardiology 2010: 26(4): pp 137-139.
Heart Disease (Eidem B, Cetta F, OтАЩLeary P, eds.). Wiley,
London, 2009.
Zangwill S, Hamilton R: Restrictive cardiomyopathy. PACE
2009: 32: pp S41-S43.
Grosse-Wortmann L, Lee W, Yoo S-J: Magnetic resonance
Zangwill SD, Naftel D, LтАЩEcuyer T, Rosenthal D, Robinson B,
(Anderson R, Baker E, Penny D, Redington A, Rigby M,
Kirklin JK, Stendahl G, Dipchand AI: Outcomes of children
Wernovsky G, eds.). Churchill-Livingstone, Philadelphia, 2009.
imaging and computed tomography. In: Paediatric Cardiology
with restrictive cardiomyopathy listed for heart transplant:
A multi-institutional study. Journal of Heart and Lung
Grosse-Wortmann L, Yoo S-J: Anatomic and functional
Transplantation 2009: 28(12): pp 1335-1340.
assessment of the pulmonary circulation. In: Principles
and Practice of Cardiac Magnetic Resonance in Congenital
Heart Disease: Form, Function and Flow (Fogel MA, ed.).
Wiley-Blackwell, Malden, MA, 2010.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 43
Jaeggi E, Tulzer G: Pharmacological and interventional fetal
Stephenson EA, Davidson A: Electrophysiology, pacing and
cardiovascular treatment. In: Paediatric Cardiology, 3rd Edition
devices. In: Paediatric Cardiology, 3rd Edition (Anderson RH,
(Anderson RH, Baker EJ, Redington A, Rigby JML, Penny D,
Baker EJ, Redington A, Rigby JML, Penny D, Wernovsky G, eds.).
Wernovsky G, eds.). Elsevier, London, England, 2009.
Elsevier, London, England, 2009.
Mahadevan V, McLaughlin P, Benson L: Catheter intervention
Funding
for baffle leak or venous obstruction. In: Cases in Adult
A novel adaptation of strain-based myocardial performance
Congenital Heart Disease (Gatzoulis MA, Webb GD, Broberg CS,
evaluation in heart rate dependent contractile remodeling.
Hideki U, eds.). Churchill- Livingstone, Philadelphia, 2009.
Gross GJ, Friedberg MK, Mertens L, Slorach C, Hui W, Jiang J,
Odland HH. Labatt Family Heart Centre Innovations Fund
Mertens L, Eyskens B, Ganame J: Systolic function. In:
($17,524 2010-2011)
Echocardiography in Pediatric and Congenital Heart Disease
(Lai W, Mertens L, Cohen M, Geva T, eds.). Blackwell,
CIHR Team in Childhood Obesity Research. McCrindle B,
London, 2009.
Anderson H, Hamilton J, Parkin P, Pencharz P. Canadian
Institutes of Health Research ($2,364,798 2009-2013)
Mertens L, Gewillig M, Hagler DJ. Tricuspid atresia and single
ventricle. In: International Textbook of Cardiology (Crawford MH,
Can post-operative biventricular pacing improve cardiac
DiMarco JP, Paulus WJ, eds.). Mosby Ltd., London, 2009.
output and decrease mechanical ventilation in children with
electro-mechanical dyssynchrony after surgical repair of
Mertens L, Marek J, Vogt M, Cohen M: Transposition of the
atrioventricular septal defect? Friedberg M, Stephenson EA.
great arteries. In: Echocardiography in Pediatric and Congenital
Labatt Family Heart Centre Innovation Funding ($48,640.50
Heart Disease (Lai W, Mertens L, Cohen M, Geva T, eds.).
2010-2012)
Blackwell, London, England, 2009.
Detection of graft rejection in heart transplant recipients by
Mertens L, Rigby ML, Horowitz ES, Anderson RH: Cross
magnetic resonance imaging. Grosse-Wortmann L, Kantor P,
sectional echocardiographic and doppler imaging. In: Paediatric
Chaturvedi R, Holtby H, Yoo S-J. Labatt Family Heart Centre
Cardiology, 3rd Edition (Anderson RH, Baker EJ, Redington A,
Innovation Fund, The Hospital for Sick Children ($24,600
Rigby JML, Penny D, Wernovsky G, eds.). Elsevier, London,
[$15,800 from SickKids REB and $8,800 from Research
England, 2009.
Awards Office] 2009-2010)
Pahl E, Dipchand A, Burch M: Heart transplantation for heart
Echocardiographic assessment of diastolic dysfunction in
failure in children. In: Heart Failure Clinics. Elsevier,
children with congenital heart disease. Golding F. Labatt
Philadelphia, 2010.
Family Heart Centre Innovation Fund ($25,000 2010)
Skippen P, Sanatani S, Mondal T, Chant-Gambacourt C, Potts J,
Environmental factors affecting cardiac development.
Kantor PF: Pediatric arrhythmias. In: Manual of Pediatric
Understanding the mechanisms of cardiac malformations.
Intensive Care (Kirpalani H, Huang LH, eds.). PeopleтАЩs Medical
Mital S. Labatt Family Heart Centre Innovation Fund
Publishing House USA Ltd., Shelton, CT, 2009.
($34,300 2010)
44
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Establishment of normal values for echocardiography
PIAF study. Fouron JC, Pasquier JC, Audibert F, Bujold E,
ventricular and vascular functional research. Mertens L,
Chetaille P, Jaeggi E, Morin L, Takser L, Weiss-Lambrou R.
Friedberg MK Bradley TJ, Jaeggi ET. Labatt Family Heart
Canadian Institutes of Health Research ($907,333
Centre Innovation Fund ($48,000 2010-2013)
2009-2014)
Genetics of heart disease in children. Mital S. Labatt Family
Prevalence and characterization of post-thrombotic syndrome
Heart Centre Innovation Fund ($450,000 2010-2013)
after pediatric cardiac surgery. McCrindle B, Manlhiot C,
Brandao L, Williams S, Chan AK, Gruenwald CE, Menjak IB.
GenomeHeart. An international network to study cardiac
Labatt Family Heart Centre Innovation Fund ($39,560
malformations. Mital S. Ontario Ministry of Research and
2009-2010)
Innovation International Strategic Opportunities Program
($149,880 2010-2013)
Primary EBV infection in the immunosuppressed setting of
organ transplantation. Determinants of virus-host interaction.
Increasing physical activity among children with congenital
Allen U, Beyene J, Dipchand A, Grunebaum E, Hebert D, Husain
heart defects. McCrindle B, Russell J, Dettmer E, Longmuir P,
S, Mazulli T, Ng V, Read S, Robinson J, Tellier R, Weitzman S.
Faulkner G. Heart and Stroke Foundation of Ontario
Canadian Institutes of Health Research ($509,125 2010-2014)
($668,349 2010-2012)
The effect of remote ischemic preconditioning on clinical and
Longitudinal assessment of the effects of bi-ventricular pacing
genomic responses to open heart surgery in children.
in AVSD тАУ 3rd round. Friedberg M, Stephenson E. Labatt
McCrindle B, Redington A, Scherer S, Van Arsdell G, Scharwtz
Family Heart Centre Innovation Fund ($48,460.50 2010)
S, Caldarone C, Coles J, Ly L, Holtby H. Heart and Stroke
Foundation of Ontario ($148,534 2009-2010) ($570,399
Molecular expression and epitopes in congenital heart block.
2010-2010)
Hamilton R, Jaeggi E, Silverman ED. ICRH Mandate Bridge
Funding ($100,000 2010-2011)
Transplant Centre Biobank. Mital S. SickKids Transplant
Centre ($300,000 2010-2012)
MRI assessment of pulmonary vascular remodeling and
vasoconstriction in pulmonary hypertension. MacGowan K,
Ventricular-ventricular interactions and their modulation for
Grosse-Wortmann L, Humpl T, Yoo S-J. Canadian Institutes
enhancement of right ventricular performance in pulmonary
of Health Research ($260,076 2009-2012)
arterial hypertension. Friedberg M, Redington A, Humpl T,
Mertens L. Canadian Institutes of Health Research
Pilot study to evaluate the effect of peri-operative diastolic
($298,500 2010-2013)
function on post-surgical course in infants with hypoplastic left
heart syndrome. Friedberg M, Mertens L, Schwartz S, Jaeggi E,
Fernandes F. Labatt Family Heart Centre Innovation Fund
($44,868 2009-2011)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 45
Division Head
Dr. Daune MacGregor
(Interim)
Full-Time
Dr. Sarah Bowdin
Dr. David Chitayat
Dr. Annette Feigenbaum
Dr. Roberto Mendoza
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Stephen Meyn
Julian Raiman
Komudi Siriwardena
Andreas Schulze
Rosanna Weksberg
Grace Yoon
Part-Time
Dr. Joe Clarke
Dr. Leona Fishman
Clinical Fellows
Dr. Ramses Badilla
Dr. Brian Chung
Dr. Hanna Faghfoury
Dr. Alison Yeung
Division of Clinical and Metabolic Genetics
Divisional Overview
The Division of Clinical and Metabolic Genetics has developed
The Division of Clinical and Metabolic Genetics provides
and participated in numerous educational activities within the
excellent clinical care and supports a variety of research,
hospital. It has important links to the Research Institute and
educational and administrative programs.
the Department of Paediatric Laboratory Medicine. The Division
directs Fellowship and Residency training programs in genetic
In August of 2009, the Division welcomed Dr. Komudi
medicine, as well as the MSc Program in Genetic Counselling.
Siriwardena, staff geneticist, who joined the genetic metabolic
During the 2009-2010 academic year, our Division was home
team. Dr. Annette Feigenbaum moved to the United States in
to six medical genetics residents and four clinical fellows, making
June 2010 but will continue with ongoing research projects.
it one of the largest training programs of its kind in Canada.
Research endeavours in the Division are a vital part of our
We have participated in several initiatives with other
program and currently focus on the translation of new genomic
subspecialties at SickKids to organize the genetic service
information for patients and their families. There is continuing
in parallel with their respective clinics. These clinics include
increase in the use of microarrays for genetic testing. The
Orthopaedic Surgery, Neurology and Cardiology.
influx of genomic data for many of our patients has affected
our patterns of practice. There are many new challenges in
As with many clinics at SickKids, transitioning our patients to
the interpretation of entirely novel data in clinical settings.
adult facilities requires careful planning. The Genetic Metabolic
The Ninth Annual Starbucks Clinical Research Summer
Good2Go team for patients between the ages of 16 and 18.
Students Competition was awarded to Dr. Andreas Schulze,
A transition strategy includes a readiness checklist, GMD
Quantitative in vivo magnetic resonance (MR) spectroscopy of
passport, formal genetic counselling, discussion of the adult
the brain in children as standard of care at SickKids; Dr. Julian
transfer plan, as well as planning a meet and greet visit to the
team has developed a genetic metabolic passport with the
Raiman, Treatment of X-linked adrenoleukdystrophy (XALD)
adult genetics program at Toronto General Hospital just prior
with Lovastatin; Dr. Sarah Bowdin, Molecular genetic testing
to their last metabolic clinic visit at SickKids. In addition,
in a cohort of paediatric patients with cardiomyopathy; and
the Genetic Metabolic team, led by Dr. Hanna Faghfoury, is
Dr. Rosanna Weksberg, Assisted Reproduction: Does folate
currently developing a transitional care checklist for genetic
metabolism play a role in determining risks to offspring?
metabolic patients aged 13 to 15. The checklist is for the
team to use with this age group to identify areas for discussion
A new annual research seed grant competition named for
in the areas of medical needs, diet, psychosocial and
Dr. Rosanna Weksberg was established. The award was
schooling. Tools from the Good2Go program will be utilized,
established to promote innovative academic, scholarly and
including the readiness checklists and Myhealth passport.
research related projects in the field of genetics. Funding will
The Phenylketonuria team held their annual education day in
be provided via donated funds to support novel research ideas
conjunction with SickKids Specialty Food Shop in April. Families
that may not be funded through conventional funding agencies.
were able to take part in cooking demonstrations and hear
The first awardees were Dr. Roberto Mendoza, Dr. Julian
from experts in the field.
Raiman and Dr. Andreas Schulze. A criteria for submission
to this competition is that there must be at least one trainee
(resident, fellow or genetic counselling student) as part of
the research team.
Residents
Dr. Almundher Al Maawali
Dr. Elaine Goh
Dr. Andrea Guerin
Dr. Natalya Karp
Dr. Shailly Jain Ghai
Dr. Joyce So
Dr. Soghra Jougheh Doust
Administrative Staff
Michelle Chu
Jennifer Costa
Michael Delaney
Susan Dukhedlin-Lalla
Laurie Furtado
Denese Henry
Andrea Jonker
Melanie Lameront
Stephanie Lappan-Gracon
Michelle Lo
Tina Martins
Tanya Palermo
Deb Taylor
Rozmin Visram
Khadine Wiltshire
A number of divisional members were honoured at this yearтАЩs
Two of our interprofessional staff members were also
Department of Paediatric Awards Day. Dr. David Chitayat
presented with awards this year. Ms. Cheryl Shuman, Director
received the Continuing Education Award for Excellence in
of Genetic Counselling, was awarded the Leadership Award
Long-term Contributions in Course Coordination. Dr. Roberto
from the Canadian College of Genetic Counsellors. This award
Mendoza received the Subspecialty Teaching Award which
is in recognition of exceptional initiative and creativity in
recognizes educational excellence in clinical teaching by a
expanding the scope and visibility of the genetic counselling
full-time faculty member in the Department of Paediatrics
profession in Canada and a significant contribution to the
within a subspecialty program. Dr. Elaine Goh received the
professional development of its members. Ms. Dawn Cordeiro,
CanMEDS Competencies Award which honours a trainee (core
a nurse with the Genetic Metabolic program, received a Daisy
paediatric and paediatric subspecialty residents and fellows)
Award in 2009. The Daisy Award is presented to a nurse at
who exemplifies one or more of the non-medical expert
SickKids who demonstrates extraordinary skill and
competencies embodied in the Royal College of Physicians
compassionate care.
and Surgeons of Canada. Dr. Brian Chung received the
Residents Research Day Award for excellence in resident,
Honours and Awards
subspecialty and fellow research. Deb Taylor received the
Chitayat D: Continuing Education Award for Excellence in
Paediatric Administrative Award in recognition of outstanding
Long-term Contributions in Course Coordination, Department
performance and excellence in all aspects of administration.
of Paediatrics, University of Toronto, The Hospital for Sick
Children, June 2010.
In addition, three teaching awards to honour excellence in
teaching within the Division were established. These awards
Goh E: Gorlin Award for Best Trainee Presentation, David W.
were voted on by the trainees and students. The Margaret M.
Smith Workshop, 2009.
Thompson Award, presented to a staff member for excellence
in teaching, was awarded to Dr. Roberto Mendoza. The Joe T.R.
Goh E: CanMEDS Competencies Award, Paediatric Subspecialty
Clarke Award, presented to a trainee for excellence in teaching,
Resident, Department of Paediatrics, University of Toronto,
was awarded to Dr. Elaine Goh, and the Interprofessional
The Hospital for Sick Children, June 2010.
Teaching Award, presented to an interprofessional staff member
for excellence in teaching, was awarded to Ms. Stacy Hewson,
Goh E: Joe T.R. Clarke Award (Teaching Excellence),
genetic counsellor with the Genetic Metabolic program.
Division of Clinical and Metabolic Genetics, May 2010.
Dr. Daune MacGregor received two awards this year - The
Jain S: Fellow Award of David Smith Workshop for the poster
College of Physicians and Surgeons of OntarioтАЩs Council Award
presentation of: тАЬA possible role for PTPN11 gene in sex
and the Paediatric Chairs of CanadaтАЩs National Paediatric
determinationтАЭ, August 2009.
Academic Leadership тАУ Clinical Practitioner Award. The CPSO
Council Award is given to a physician who has demonstrated
MacGregor DL: Council Award, The College of Physicians and
excellence and comes closest to meeting the societyтАЩs vision
Surgeons of Ontario, November 2009.
of an тАЬideal physician.тАЭ The PCCтАЩs Leadership Award recognizes
Dr. MacGregorтАЩs outstanding contributions to leadership in
MacGregor DL: National Paediatric Academic Leadership - Clinical
clinical care, professional activities and education and training.
Practitioner Award, Paediatric Chairs of Canada, June 2010.
48
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Mendoza-Londono R: Subspecialty Teaching Award for
Bradshaw PS, Meyn MS. A new means to deal with ends:
Excellence in Clinical Teaching, Department of Paediatrics,
Heat shock protein regulation of the DNA damage response
University of Toronto, The Hospital for Sick Children, June 2010.
protein Apollo. Cell Cycle 2009 8(14): pp 2138-2139.
Mendoza-Londono R: Margaret W. Thompson Award -
Breakey VR, Meyn S, Ng V, Allen C, Dokal I, Lansdorp PM,
Excellence in Teaching, May 2010.
Abla O, Dror Y. Hepatitis-associated aplastic anemia presenting
as a familial bone marrow failure syndrome. Journal of Pediatric
Raiman J: Toronto EMS Citizenship Award, 2010.
Hematology/Oncology 2009: 31(11): pp 884-887.
Publications
Cameron JM, Levandovskiy V, MacKay N, Utgikar R,
Alazami AM, Schneider SA, Bonneau D, Pasquier L,
Ackerley C, Chiasson D, Halliday W, Raiman J, Robinson BH:
Carecchio M, Kojovic M, Steindl K, de Kerdanet M, Nezarati MM,
Identification of a novel mutation in GYS1 (muscle-specific
Bhatia KP, Degos B, Goh E, Alkuraya FS. C2orf37 mutational
glycogen synthase) resulting in sudden cardiac death, that
spectrum in Woodhouse-Sakati syndrome patients. Clinical
is diagnosable from skin fibroblasts. Molecular Genetics
Genetics 2010: April 6 [Epub ahead of print].
and Metabolism 2009: 98(4): pp 378-382.
Al-Dirbashi OY, Fisher L, McRoberts C, Siriwardena K,
Cameron JM, Maj M, Levandovskiy V, Barnett CP, Blaser S,
Geraghty M, Chakraborty P: Identification of a neonate
Mackay N, Raiman J, Feigenbaum A, Schulze A, Robinson BH:
with hepatorenal tyrosinemia by combined routine newborn
Pyruvate dehydrogenase phosphatase 1 (PDP1) null mutation
screening for succinylacetone, acylcarnitines and amino
produces a lethal infantile phenotype. Human Genetics 2009:
acids. Clinical Biochemistry 2010: 43(7-8): pp 691-693.
125(3): pp 319-26.
Barnett CP, Jaeggi E, Han RK, Nevo O, Keating S, Shannon P,
Chitayat D, Glanc P: Diagnostic approach in prenatally detected
Bitnun A, Chitayat D: Unusual cardiac presentation of
genital abnormalities. Ultrasound Obstetrics and Gynecology
congenital cytomegalovirus infection. Ultrasound Obstetrics
2010: 35(6): pp 637-646.
and Gynaecology 2010: 35(1): pp 119-120.
Fernandez BA, Roberts W, Chung B, Weksberg R, Meyn S,
Barnett CP, Lam WC, Schulze A: Premature retinal detachment
Szatmari P, Joseph-George AM, Mackay S, Whitten K, Noble B,
causing unilateral blindness in a 12 year old girl with gyrate
Vardy C, Crosbie V, Luscombe S, Tucker E, Turner L, Marshall
atrophy. Journal of Inherited Metabolic Disease 2009: 32(5)
CR, Scherer SW. Phenotypic spectrum associated with de
pp 670-671.
novo and inherited deletions and duplications at 16p11.2 in
Barnett C, Langer JC, Hinek A, Bradley TJ, Chitayat D: Looking
disorder. Journal of Medical Genetics 2010: 47(3): pp 195-203.
individuals ascertained for diagnosis of autism spectrum
past the lump: Genetic aspects of inguinal hernia in children.
Journal of Pediatric Surgery 2009: 44(7): pp 1423-1431.
Gahunia HK, Babyn PS, Kirsch S, Mendoza-Londono R:
Imagining of SOHX-associated anomalies. Seminars in
Basel-Vanagaite L, Shaffer L, Chitayat D: Keppen-Lubinsky
Muscularskeletal Radiology 2009:13(3): pp 236-54.
syndrome: Expanding the phenotype. American Journal of
Medical Genetics Part A 2009: 149A: pp 1827-1829.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 49
Goh ES, Li C, Horsburgh S, Kasai Y, Kolomietz E, Morel CF.
Koifman A, Feigenbaum A, Bi W, Shaffer LG, Rosenfeld J,
The Roberts syndrome/SC phocomelia spectrum тАУ A case
Blaser S, Chitayat D: A homozygous deletion of 8q24.3
report of an adult with review of the literature. American
including the NIBP gene associated with severe developmental
Journal of Medical Genetics Part A 2010: 152A(2): pp.
delay, dysgenesis of the corpus callosum, and dysmorphic
472-478.
facial features. American Journal of Medical Genetics Part A
2010: 152A: pp 1266-1272.
Grafodatskaya D, Choufani S, Ferreira JC, Butcher DT,
Lou Y, Zhao C, Scherer SW, Weksberg R: EBV transformation
Lehman AM, Eydoux P, Doherty D, Glass IA, Chitayat D,
and cell culturing destabilizes DNA methylation in human
Chung BY, Langlois S, Yong SL, Lowry RB, Hildebrandt F,
lymphoblastoid cell lines. Genomics 2010: 95(2):73-83.
Trnka P: Co-occurrence of Joubert syndrome and Jeune
asphyxiating thoracic dystrophy. American Journal of
Hartley JL, Zachos NC, Dawood B, Donowitz M, Forman J,
Medical Genetics Part A 2010: 152(6): pp 1411-1419.
Pollitt RJ, Morgan NV, Tee L, Gissen P, Kahr WH, Knisely AS,
Watson S, Chitayat D, Booth IW, Protheroe S, Murphy S,
Patel C, Hardy G, Cox P, Bowdin S, McKeown C, Russell AB:
de Vries E, Kelly DA, Maher ER: Mutations in TTC37 Cause
Mosaic trisomy 1q: The longest surviving case. American
Trichohepatoenteric Syndrome (phenotypic diarrhoea of
Journal of Medical Genetics Part A 2009: 149A(8): pp
infancy). Gastroenterology 2010: 138(7): pp 2388-2398.
1795-1800.
Horike S, Ferreira JC, Meguro-Horike M, Choufani S, Smith AC,
MacRae AR, Chodirker BN, Davies GA, Palomaki GE, Knight GJ,
Shuman C, Meschino W, Chitayat D, Zackai E, Scherer SW,
Minett J, Kavsak PA, Toi A, Chitayat D, Van Caeseele PG:
Weksberg R: Screening of DNA methylation at the H19
Second and first trimester estimation of risk for Down
promoter or the distal region of its ICR1 ensuresefficient
syndrome: Implementation and performance in the SAFER
detection of chromosome 11p15 epimutations in Russell-Silver
study. Prenatal Diagnosis 2010: 30(5): pp 459-466.
syndrome. American Journal of Medical Genetics Part A 2009:
149: pp 2415-2423.
McClelland V, Cullup T, Bodi I, Ruddy D, Buj-Bello A, Biancalana V,
Jaeggi ET, Chitayat D, Taylor G: Atrial standstill associated with
Trounce J, Laporte J, Mohammed S, Sewry C, Raiman J,
loss of atrial mycocytes: A rare cause of fetal bradyarrhythmia.
Jungbluth H: Vici associated with sensorineural hearing loss
Heart Rhythm 2009: 6(9): pp 1370-1372.
and evidence of neuromuscular involvement on muscle biopsy.
Boehm J, Bitoun M, Miller O, Jan W, Menson E, Amaya L,
American Journal of Medical Genetics 2010: 152A(3): pp 741-747.
Jain S, Yang P, Farrell SA. A case of 8q22.1 microdeletion
without the Nablus mask-like facial syndrome phenotype.
Mir A, Kaufman L, Noor A, Motazacker MM, Jamil T, Azam M,
European Journal of Medical Genetics 2010: 53: pp 108-110.
Kahrizi K, Rafiq MA, Weksberg R, Nasr T, Naeem F, Tzschach A,
Kuss AW, Ishak GE, Doherty D, Ropers HH, Barkovich AJ,
Klieger-Grossmann C, Djokanovic N, Chitayat D, Koren G:
Najmabadi H, Ayub M, Vincent JB: Identification of mutations
In utero exposure to therapeutic radiation for Hodgin lymphoma.
in TRAPPC9, which encodes the NIK- and IKK-beta-binding
Canadian Family Physician 2009: 55(10): pp 988-991.
protein, in nonsyndromic autosomal-recessive mental
retardation. American Journal of Human Genetics 2009:
85(6): pp 909-915.
50
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Nishimura G, Dia J, Lausch E, Unger S, Megarbane A, Kitoch H,
Thompson MD, Nezarati MM, Gillessen-Kaesbach G,
Kim O, Cho T, Bedeschi F, Mendoza-Londono R, Silengo M,
Meinecke P, Mendoza-Londono R, Mornet E, Brun-Heath I,
Schmidt-Rimpler M, Spranger J, Zabel B, Ikegawa S, Superti-
Squarcioni CP, Legeai-Mallet L, Munnich A, Cole DE:
Furga A: Sponodylo-epiphyseal dysplasia, maroteaux type
Hyperphosphatasia with seizures, neurologic deficit, and
(Pseudo-Morquio syndrome type2) and parastremmatic
characteristic facial features: Five new patients with Mabry
dysplasia are caused by TRPV4 mutations. American Journal
syndrome. American Journal of Medical Genetics 2010:
of Medical Genetics 2010: 152A(6): pp 1443-1449.
152A(7): pp 1661-1669.
Nulman I, Sgro M, Barrera M, Chitayat D, Cairney J, Koren G:
Yang T, Mendoza-Londono R, Lu H, Tao J, Li K, Keller B,
Long-term neurodevelopment of children exposed in utero to
Jiang MM, Shah R, Chen Y, Bertin TK, Engin F, Dabovic B,
cyclosporin after maternal renal transplant. Pediatric Drugs
Rifkin DB, Hicks J, Jamrich M, Beaudet AL, Lee B: E-selectin
2010: 12(2): pp 113-122.
ligand-1 regulates growth plate homeostasis in mice by inhibiting
the intracellular processing and secretion of mature TGF-beta.
Pinto D, Chunghttp://www.nature.com/nature/journal/v466/
Journal of Clinical Investigation 2010: 120(7): pp 2474-2485.
n7304/full/nature09146.html - a1 B, Cytrynbaumhttp://www.
nature.com/nature/journal/v466/n7304/full/nature09146.
Yinon Y, Kingdom JC, Proctor LK, Kelly EN, Salle JL, Wherrett D,
html - a1 C, Weksberg R, Betancur C: Functional impact of
Keating S, Nevo O, Chitayat D: Hypospadias in males with
global rare copy number variation in autism spectrum disorder.
intrauterine growth restriction due to placental insufficiency:
Nature 2010: June 9 [Epub ahead of print].
the placental role in the embryogenesis of male external
Proctor LK, Toal M, Keating S, Chitayat D, Okrun N, Windrim RC,
152A(1): pp 75-83.
genitalia. American Journal of Medical Genetics Part A 2010:
Smith GC, Kingdom JC: Placental size and the prediction of
severe early-onset intrauterine growth restriction in women
Books and Book Chapters
with low pregnancy-associated plasma protein-A. Ultrasound
Bowdin S, Rowland H: Genetic syndromes and PICU - Specific
Obstetrics and Gynecology 2009: 34(3): pp 274-282.
features. In: Oxford Handbook of Pediatric Intensive Care
(Barry P, Morris K, Ali T, eds.). Oxford University Press, Oxford,
Rohrbach M, Chitayat D, Maegawa G, Shanske S, Davidzon G,
UK, 2010.
Chong K, Clarke JT, Toi A, Tarnopolsky M, Robinson B, Blaser S:
Intracerebral periventricular pseudocysts in a fetus with
Hoffmann GF, Schulze A: Organic acidurias. In: Pediatric
mitochondrial depletion syndrome: An association or
Endocrinology and Inborn Errors of Metabolism (Sarafoglou K,
coincidence. Fetal Diagnosis Therapy 2009: 25(2): pp 177-182.
Hoffmann GF, Roth SK, eds.). McGraw-Hill, New York, 2009.
Roifman E, Chitayat D: Combined immunodeficiency, facial
Schulze A: Creatine deficiency syndromes. In: Pediatric
dysmorphism, optic nerve atrophy, skeletal anomalies and
Endocrinology and Inborn Errors of Metabolism (Sarafoglou K,
developmental delay: A new syndrome. Clinical Genetics 2009:
Hoffmann GF, Roth SK, eds.). McGraw-Hill, New York, 2009.
76(5): pp 449-457.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 51
Schulze A, Matern D, Hoffmann GF: Newborn screening. In:
Autism Treatment Network: Cooperative multi-center program
Endocrinology and Inborn Errors of Metabolism (Sarafoglou K,
for research and treatment of autism. Roberts SW, Loh A,
Hoffmann GF, Roth SK, eds.). McGraw-Hill, New York, 2009.
Feigenbaum A, Weiss S, Marcon C, Goldfarb C, Berall G,
Bradley E, Brian J, Freeman N, Atkinson A, Taylor M, Stinson J,
Weksberg R, Shuman C: Beckwith-Wiedemann syndrome and
Mitchell S, Green P, Chitayat D. Autism Speaks ($408,000
hemihypertrophy. In: Management of Genetic Syndromes, 3rd
2008-2010)
Edition (Cassidy SB, Allanson JE, eds.). John Wiley & Sons, Inc.,
New York, 2010.
Brain and whole body anatomy study in AGAT and GAMT mice
with high-resolution magnetic resonance imaging. Schulze A.
Funding
Mead Johnson/Weston Endowment 2010 ($13,790 2010)
A phase 2, fixed-sequence, open-label, switch-over study of
the safety and tolerability of HPN-100 compared to sodium
Canadian Molecular Cytogenetics Platform. Friedman JM,
phenylbutyrate in children 6тАУ17 years of age with urea cycle
Chitayat D. Canadian Foundation for Innovation ($4,512,925
disorders, with a long-term safety extension. Feigenbaum A.
2005-2010)
Hyperion Therapeutics ($31,878 2009-2011)
Common pathways of human DNA double strand break repair
A phase 3, randomized, double-blind, cross-over, active-
and telomere maintenance. Meyn MS. Canadian Cancer
controlled study of the efficacy and safety of HPN-100,
Society/SickKids Research Institute ($122,877 2009-2014)
glyceryl tri-(4-phenylbutyrate), for the treatment of adults
with urea cycle disorders (Help UCD) Feigenbaum A.
Constitutional epigenetic and genetic errors and the risk of
Hyperion Therapeutics ($30,660/patient 2010-2012)
paediatric cancer. Weksberg R. SickKids Foundation New
Ideas Grant ($50,000 2009-2010)
A phase 3, open-label study of the safety of HPN-100 for
the long-term treatment of urea cycle disorders (Treat UCD)
Cooperative multi-center program for research and treatment of
Feigenbaum A. Hyperion Therapeutics ($33,560/patient
autism. Roberts SW, Loh A, Feigenbaum A, Weiss S, Marcon C,
2010-2012)
Goldfarb C, Berall G, Bradley E, Brian J, Freeman N, Atkinson A,
Taylor M, Stinson J, Mitchell S, Green P. Autism Treatment
Autism Research Training (ART) Program. Fombonne E,
Network ($408,000 2008-2010)
Evans AC, Mottron L, Scherer S, Volden J, Bryson S, Iarocci G,
Roberts W, Smith I, Zwaigenbaum L, Burack J, Mirenda P,
Delineating the natural history of caffey disease. Mendoza R,
Rouleau G, Szatmari P, Weksberg R. Canadian Institutes
Guerin A. Dr. R. Weksberg Research Grant Competition
of Health Research ($1,950,000 2009-2015)
($6,980 2010-2011)
52
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Developing and implementing a transitional care checklist in
Lysosomal storage disease chart review. Raiman J.
the genetic metabolic clinic at The Hospital for Sick Children.
Starbucks Summer Studentship Award ($4,800 2010)
Raiman J, Faghfoury H, Burr L, Sappleton K. Dr. R. Weksberg
Research Grant Competition ($6,180 2010-2011)
Organization for the study of sex-differences, third annual
meeting. Weksberg R. Canadian Institute of Health Research
DNA damage responses in human hematopoietic stem and
($15,000 2009)
progenitor cells тАУ A pilot study. Meyn MS. SickKids Cancer
Center New Ideas Grant ($49,600 2009-2010)
Patient iPS cells with copy number variations to model
neuropsychiatric disorders. Ellis J, Scherer S, Weksberg R.
DNA sequencing as a diagnostic tool for FBP1 gene mutations
National Institutes of Health ($207,388 2009-2011)
in Costa Rican patients with fructose-1, 6-biphosphatase
deficiency. Schulze A, Badilla R, Stockley T. Dr. R. Weksberg
PKU 015. A phase 3b open-label study to evaluate the effect
Research Grant Competition ($6,880 2010-2011)
of Kuvan┬о on neurocognitive function, maintenance of blood
phenylalanine concentrations, safety, and population
Factors associated with making a diagnosis in patients
pharmacokinetics in young children with phenylketonuria.
presenting with cleft lip and palate or cleft palate alone. Bowdin S.
Feigenbaum A. Biomarin ($38,780/patient 2009-2016)
Starbucks Summer Studentship Award ($5,000 2010)
Prevalence of creatine deficiency syndromes and genetic
Funding of an autism intervention research network for physical
variability in creatin metabolism in children with ASD: A pilot
health. Roberts SW, Loh A, Feigenbaum A, Weiss S, Marcon C,
study. Schulze A, Loh A, Roberts W, Scherer S, Anagnostou E,
Goldfarb C, Berall G, Bradley E, Brian J, Freeman N, Atkinson A,
Chun-Hui Tsai A, Reynods A, Bauman M. Autism Intervention
Taylor M, Stinson J, Mitchell S, Green P, Chitayat D. Health
Research Network for Physical Health ($250,000 2009)
Resources and Services Administration ($400,882 2009-2011)
Quantitative in vivo magnetic resonance (MR) spectroscopy of
Funding of an autism intervention research network for physical
the brain in children as standard of care at SickKids. Schulze A.
health. Roberts SW, Loh A, Feigenbaum A, Weiss S, Marcon C,
Starbucks Summer Studentship Award ($4880 2009)
Goldfar C, Berall G, Bradley E, Brian J, Freeman N, Atkinson A,
Taylor M, Stinson J, Mitchell S, Green P: Autism Treatment
Network - HRSA award ($408,000 2009-2011)
The SickKids Research Institute infrastructure grant. Meyn MS,
Rossant J. Canadian Foundation for Innovation ($91,119,176
2008-2013)
Identifying epigenetic targets of lithium: An in-vitro pilot study.
Ickowicz A, Weksberg R, Butcher D. Psychiatric Endowment
Fund ($23,375 2009-2010).
Treatment of GAMT (guanidinoacetate methyltransferase)
deficiency with high-dose ornithine to reduce the accumulation
of the neurotoxin guanidinoacetate by inhibition of the AGAT
Investigation of intrauterine growth restriction by gene
enzyme (arginine:glycine amidinotransferase) Schulze A.
expression and DNA methylation profiling. Weksberg R,
Heinz/Mead Johnson/Weston Endowment 2010
Chitayat D, Kingdom J, Keating A. Canadian Institutes
($13,000 2010)
of Health Research ($383,883 2008-2011)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 53
Division Head
Dr. Shinya Ito
Full-Time
Dr. Gideon Koren
Dr. Irena Nulman
Dr. Margaret Thompson
Part-Time
Dr. David Juurlink
Dr. Lisa Thurgur
Scientific Staff
Dr. Patricia Harper
Cross-Appointees/
Clinical
Dr. Sylvain Baruchel
Dr. Sheila Jacobson
Dr. Prashant Joshi
Dr. Christopher Parshuram
Dr. Savithiri Ratnapalan
Dr. Denis Scolnik
Dr. Marco Sivilotti
Dr. Bonnie Stevens
Dr. Anna Taddio
Cross-Appointees/
Scientific
Dr. Lidia Derewlany
Dr. Alejandro Nava-Ocampo
Clinical Fellows
Dr. Facundo Garcia
Bournissen
Dr. Shahnaz Chaudhry
Division of Clinical Pharmacology & Toxicology
Divisional Overview
The Division is one of the two major training sites of the Royal
The Division of Clinical Pharmacology and Toxicology focuses on
College-accredited Clinical Pharmacology Residency program
a wide range of drug-related issues in paediatrics. The Division
of the University of Toronto. Our medical residency training
is one of the largest and the most active paediatric pharmacology
program spearheaded the recent change of the specialty
programs internationally. Our major clinical activities include
residency training structure to add Emergency Medicine to the
a consultation service, the Motherisk program (a reproductive
existing four entry disciplines, which include Paediatrics. This
toxicology program), the Ontario Poison Centre, and DART (Drug
change enables us to train residents with emergency medicine
Allergy, Reactions, and Toxicity) clinic in collaboration with the
background in the clinical toxicology stream in our education
Division of Allergy and Immunology to provide specialized
program. On the international scene, SickKids Clinical
outpatient follow-up and management for those with various
Pharmacology has been chosen as one of the four leading
drug/toxin-related problems. The two information centres
centres in the European Union-funded international initiative
receive annually about 35,000 (Motherisk) and 75,000 (Poison
of Paediatric Pharmacology training to address global needs
Centre) inquires, which have reached the limit of the response
of paediatric clinical pharmacologists to enhance safe and
capacity of the systems. Motherisk Program directed by
effective drug therapy in children worldwide.
Dr. Gideon Koren continues to generate and disseminate new
knowledge in the field of drug safety for fetus and breastfeeding
Research in the Division includes drug metabolizing enzymes
babies. The 25th anniversary of the Motherisk program was
and their regulation, drug transporters, placental and mammary
celebrated during the annual Motherisk Update conference,
gland drug transport and metabolism, and reproductive
which attracted more than 200 participants. The Ontario Poison
toxicology and teratology. The breadth and depth of these basic
Centre led by Dr. Margaret Thompson has now become a hub to
and clinical research programs are shown in the publications
medical toxicology training in Canada, attracting many residents
(over 60) and funding records (over 2 million during this time
and fellows nationally and internationally.
period). Our Division members serve as editor and associate
editor of key journals in the discipline, showing strong
leadership in the field.
Dr.
Dr.
Dr.
Dr.
Dr.
Hisaki Fujii
Rinat Hackmon
Miho Inoue
Geert Willem Jong
Aleksey Kazmin
Dr.
Dr.
Dr.
Dr.
Chagit Klieger-Grossman
Alla Osadchy
Toshihiro Tanaka
Sachi Sakaguchi
Research Fellows
Dr. Masako Asoh
Dr. Parvaneh Yazdani Brojeni
Dr. Nada Djokanovic
Dr. Taro Kamiya
Dr.
Dr.
Dr.
Dr.
Parvaz Madadi
Ilan Matok
Mina Ogawa
Hendrick Kah Poh Tan
resident
Bandar Baw
Research Associate
Dr. Katarina Aleksa
Honours and Awards
Ebrahimi N, Maltepe C, Bournissen FG, Koren G: Nausea and
Nulman I: Andre Boivin Professorship in Maternal/Fetal
vomiting of pregnancy: Using the 24-hour Pregnancy-Unique
Toxicology. Duchesnay Inc., 2009.
Quantification of Emesis (PUQE-24) scale. Journal of Obstetrics
and Gynaecology Canada 2009: 31: pp 803-807.
Nulman I: Schwarz-Reisman SickKids Scholar Award,
Hospital for Sick Children, 2009.
Einarson A, Choi J, Einarson TR, Koren G: Adverse effects of
antidepressant use in pregnancy: An evaluation of fetal growth
Publications
and preterm birth. Depression and Anxiety 2010: 27: pp 35-38.
Banach R, Boskovic R, Einarson T, Koren G: Long-term
developmental outcome of children of women with epilepsy,
Elis A, Lishner M, Walker S, Atias D, Korenberg A,
unexposed or exposed prenatally to antiepileptic drugs: a meta-
Koren G: Doxorubicin in lymphoma: Association between
analysis of cohort studies. Drug Safety 2010: 33: pp 73-79.
pharmacokinetic variability and clinical response.
Therapeutic Drug Monitoring 2010: 32(1): pp 50-52.
Chan WS, Koren G, Barrera M, Rezvani M, Knittel-Keren D,
Nulman I: Neurocognitive development of children following in
Elzagallaai AA, Knowles SR, Rieder MJ, Bend JR, Shear NH,
utero exposure to labetalol for maternal hypertension. A cohort
Koren G: In vitro testing for the diagnosis of anticonvulsant
study using a prospectively collected database. Hypertension
hypersensitivity syndrome: a systematic review. Molecular
in Pregnancy 2010: 29: pp 271-283.
Diagnosis & Therapy 2009: 13: pp 313-330.
Chuang A, Ito S: Ambient tonicity and intestinal CYP3A. Expert
Garcia-Bournissen F, Nesterenko M, Karaskov T, Koren G:
Opinion on Drug Metabolism & Toxicology 2010: 6: pp 883-893.
Passive environmental exposure to cocaine in Canadian
children. Paediatric Drugs 2009: 11: pp 30-32.
Ciszkowski C, Madadi P, Phillips MS, Lauwers AE, Koren G:
Codeine, ultrarapid-metabolism genotype, and postoperative
Garcia-Bournissen F, Altcheh J, Giglio N, Mastrantonio G,
death. New England Journal of Medicine 2009: 361: pp
Omar Della Vedova C, Koren G: Pediatric clinical pharmacology
827-828.
studies in chagas disease: Focus on Argentina. Paediatric
Drugs 2009: 11: pp 33-37.
de Wildt SN, Ito S, Koren G: Challenges for pharmacogenetics
studies in children: CYP3A phenotyping as an example.
Garcia-Bournissen F, Altcheh J, Paunchaud A, Ito S: Is
Drug Discovery 2009: 14: pp 6-15.
nifurtimox for treatment for Chagas disease compatible
with breastfeeding? Archives of Disease in Childhood 2010:
de Wildt SN, Kearns GL, Murry DJ, Koren G, van den Anker JN:
Ontogeny of midazolam glucuronidation in preterm infants.
European Journal of Clinical Pharmacology 2010: 66(2): pp
165-170.
lab manager
Mr. Joey Gareri
Administrative Staff
Ms. Niki Balamatsis
Ms. Sarah Bondy
Ms.
Ms.
Ms.
Ms.
Hila Halshtok
Leah Moscato
Donna Tedesco
Shannon VanderKooi
95: pp 224-228.
Gareri J, Brien J, Reynolds J, Koren G: Potential role of the
Han JY, Choi JS, Chun JM, Park HD, Lee SY, Kim CH, Park Q,
placenta in fetal alcohol spectrum disorder. Paediatric Drugs
Nava-Ocampo AA, Koren G: Pregnancy outcome of women
2009: 11: pp 26-29.
transfused during pregnancy with blood products inadvertently
obtained from donors treated with acitretin. Journal of
Gijsen V, de Wildt SN, Ito S: Probability of rash related to
Obstetrics and Gynaecology 2009: 29: pp 694-697.
gabapentine therapy in a child. Annals of Pharmacotherapy
2009: 43: pp 387-389.
Hutson JR, Aleksa K, Pragst F, Koren G: Detection and
quantification of fatty acid ethyl esters in meconium by
Gill SK, Maltepe C, Mastali K, Koren G: The effect of
headspace-solid-phase microextraction and gas chromatography
Acid-reducing pharmacotherapy on the severity of nausea
mass spectrometry. Journal of Chromatography. B,
and vomiting of pregnancy. Obstetrics and Gynecology
Analytical Technologies in the Biomedical and Life
International 2009: 2009: p 585269.
Sciences 2009: 877: pp 8-12.
Gill SK, Nguyen P, Koren G: Adherence and tolerability of
Inoue M, Caldarone CA, Frndova H, Cox P, Ito S, Taddio A,
iron-containing prenatal multivitamins in pregnant women
Guerguerian AM: Safety and efficacy of ketorolac in children
with pre-existing gastrointestinal conditions. Journal of
after cardiac surgery. Intensive Care Medicine 2009: 35:
Obstetrics and Gynaecology 2009: 29: pp 594-598.
pp 1584-1592.
Glatstein MM, Garcia-Bournissen F, Giglio N, Finkelstein Y,
Ito S: Breast cancer risk and history of being breastfed.
Koren G: Pharmacologic treatment of hyperthyroidism during
Epidemiology 2009: 20: p 155.
lactation. Canadian Family Physician 2009: 55: pp 797-798.
Ito S: Clinical investigation in Pediatrics. Pediatric Drugs 2009:
Golubchik D, Polturak E, Koren G, Lipson SG: A high resolution
11: pp 67-68.
magneto-optical system for imaging of individual magnetic
flux quanta. Optics Express 2009: 17: pp 16160-16165.
James L, Ito S: Neonatal pharmacology: rational therapeutics
Grausgruber A, Schony W, Grausgruber-Berner R, Koren G,
Therapeutics 2009: 86: pp 573-577.
for the most vulnerable. Clinical Pharmacology and
Apor BF, Wancata J, Meise U: тАЬSchizophrenia has many facesтАЭ
тАУ evaluation of the Austrian Anti-Stigma-Campaign 2000-2002.
Psychiatrische Praxis 2009: 36: pp 327-333.
Klieger-Grossmann C, Djokanovic N, Chitayat D, Koren G:
In utero exposure to therapeutic radiation for Hodgkin
lymphoma. Canadian Family Physician 2009: 55: pp 988-991.
Grupp SG, Greenberg ML, Ray JG, Busto U, Lanctot KL,
Nulman I, Koren G: Pediatric cancer rates after universal
Klieger C, Pollex E, Kazmin A, Koren G: Hypoglycemics:
folic acid flour fortification in Ontario. Journal of Clinical
Pharmacokinetic considerations during pregnancy.
Pharmacology 2010: May 10 [Epub ahead of print].
Therapeutic Drug Monitoring 2009: 31: pp 533-541.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 57
Koren G: Training clinicians in pediatric pharmacology-
Madadi P, Moretti M, Djokanovic N, Bozzo P, Nulman I,
toxicology: The Toronto model. Paediatric Drugs 2009:
Ito S, Koren G: Guidelines for maternal codeine use during
11: pp 60-62.
breastfeeding. Canadian Family Physician 2009: 55: pp
1077-1078.
Koren G, Rieder M, MacLeod SM: The global alliance
for pediatric pharmacology: The future is here and now.
Matok I, Gorodischer R, Koren G, Landau D, Wiznitzer A,
Paediatric Drugs 2009: 11: pp 4-5.
Levy A: Exposure to folic acid antagonists during the first
trimester of pregnancy and the risk of major malformations.
Koren G: ACP Journal Club. SSRIs in early pregnancy were
British Journal of Clinical Pharmacology 2009: 68: pp 956-962.
associated with increased risk for septal heart defects but
not major congenital malformations overall. Annals of Internal
Matok I, Gorodischer R, Koren G, Sheiner E, Wiznitzer A,
Medicine 2009: 151: JC6-JC15.
Uziel E, Levy A: The safety of h2 blockers use during pregnancy.
Journal of Clinical Pharmacology 2010: 50: pp 81-87.
Koren G, Fantus E, Nulman I: Managing fetal alcohol spectrum
disorder in the public school system: A needs assessment pilot.
Moller M, Koren G: Unsuspected prenatal opioid exposure:
Canadian Journal of Clinical Pharmacology 2010: 17: pp 79-89.
Long-term detection by alternative matrices. Therapeutic
Drug Monitoring 2010: 32(1): pp 1-2.
Koren G, Nulman I: Editorial. Drugs in pregnancy: Associations,
causation and misperceptions. Archives of Pediatrics &
Adolescent Medicine 2010: 164: pp 494-495.
Nulman I, Koren G: Pharmacokinetic comparison of a delayedrelease combination of doxylamine and pyridoxine (Diclectin)
and oral solutions of these drugs in healthy women. The
Lau A, Duong TT, Ito S, Young RSM: The differential effects of
Canadian Journal of Clinical Pharmacology 2009: 16: pp
IVIG and salicylate on TNF-production and effect or function
400-406.
during evolution of Kawasaki Disease. Arthritis & Rheumatism
2009: 60: pp 2131-2141.
Nulman I, Rovet J, Barrera M, Knittel-Keren D, Feldman BM:
Lau A, Duong TT, Ito S, Wilson GJ, Young RSM: Inhibition of
and vomiting of pregnancy. Journal of Pediatrics 2009: 155:
MMP-9 activity improves coronary outcome in an animal model
pp 45-50.
Neurodevelopment of children exposed to maternal nausea
of Kawasaki Disease. Clinical and Experimental Immunology
2009: 157: pp 300-309.
Nulman I, Sgro M, Barrera M, Chitayat D, Cairney D, Koren G:
Long-term neurodevelopment of children exposed in utero to
Lee CYW, Ratnapalan S, Thompson MA, Nathan P: Unusual
cyclosporin after maternal renal transplant. Paediatric Drugs
reactions to 5-HT3 receptor antagonists in a child with
2010: 12: pp 113-122.
rhabdomyosarcoma. Canadian Journal of Clinical Pharmacology
2010: 16: pp e1-e4.
OтАЩBrien L, Baumer C, Thieme D, Sachs H, Koren G: Hair as a
novel noninvasive method to study the impact of pregnancy on
CYP2D6 metabolizing capacity. Therapeutic Drug Monitoring
2009: 31: pp 531-532.
58
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Osadchy A, Kazmin A, Koren G: Nicotine replacement therapy
Staroselsky A, Klieger-Grossmann C, Garcia-Bournissen F,
during pregnancy: Recommended or not recommended?
Koren G: Exposure to fifth disease in pregnancy. Canadian
Journal of Obstetrics & Gynaecology Canada 2009: 31:
Family Physician 2009: 55: pp 1195-1198.
pp 744-747.
Taddio A, OтАЩBrien L, Ipp M, Stephens D, Goldbach M, Koren G:
Sarkar M, Koren G, Kalra S, Ying A, Smorlesi C, De Santis M,
Reliability and validity of observer ratings of pain using the
Diav-Citrin O, Avgil M, Voyer Lavigne S, Berkovich M,
visual analog scale (VAS) in infants undergoing immunization
Einarson A: Montelukast use during pregnancy: A multicentre,
injections. Pain 2009: 147: pp 141-146.
prospective, comparative study of infant outcomes. European
Journal of Clinical Pharmacology 2009: August 26 [Epub ahead
Tan KP, Wang B, Yang M, Boutros PC, MacAulay J, Xu H,
of print].
Chuang AI, Kosuge K, Yamamoto M, Takahashi S, Wu A,
Ross DD, Harper PA, Ito S: Aryl hydrocarbon receptor (AHR)
Sakaguchi S, Garcia-Bournissen F, Kim R, Scwarz UI,
is a transcriptional activator of human breast cancer resistance
Nathan PC, Ito S: Prolonged neutropenia after irinotecan-based
protein (BCRP/ABCG2). Molecular Pharmacology 2010:
chemotherapy in a child with polymorphisms of UGT1A1
May 10 [Epub ahead of print].
and SLCO1B1. Archives of Disease in Childhood 2009: 94:
pp 981-982.
Tanaka T, Ito S: Novel H1N1 influenza and pregnancy. Expert
Opinion in Obstetrics and Gynecology 2010: 5: pp 169-175.
Schoeman K, Bend JR, Hill J, Nash K, Koren G: Defining
a lowest observable adverse effect hair concentrations
Tanaka T, Nakajima K, Murashima A, Garcia-Bournissen F,
of mercury for neurodevelopmental effects of prenatal
Koren G, Ito S: Safety of neuraminidase inhibitors, oseltamivir
methylmercury exposure through maternal fish consumption:
and zanamivir for pregnant and breastfeeding women during
A systematic review. Therapeutic Drug Monitoring 2009: 31:
the current pandemic of novel influenza A (H1N1) virus.
pp 670-682.
Canadian Medical Association Journal 2009: 181: pp 55-58.
Shor S, Nulman I, Kulaga V, Koren G: Heavy in utero ethanol
Thomson S, Koren G, Van Steen V, Rieder M, Van Uum SH:
exposure is associated with the use of other drugs of abuse
Testosterone concentration in hair of hypogonadal men with
in a high-risk population. Alcohol 2009: December 21 [Epub
and without testosterone replacement therapy. Therapeutic
ahead of print].
Drug Monitoring 2009: 31: pp 779-782.
Simon A, Liu GZ, Koren G, Choudhary G: cANF causes
vanderVaart S, Gijsen VM, de Wildt SN, Koren G: A systematic
endothelial cell hyperpolarization by activation of chloride
review of the therapeutic effects of Reiki. Journal of Alternative
channels. Peptides 2009: 30: pp 2337-2342.
and Complementary Medicine 2009: 15: pp 1157-1169.
Staroselsky A, Fantus E, Sussman R, Sandor P, Koren G,
Vohra S, Akoury H, Bernstein P, Einarson TR, Pairaudeau N,
Nulman I: Predictors of behavioural phenotype in children with
Taddio A, Koren G: The effectiveness of Proctofoam-HC for
psychiatric disorders exposed in utero to alcohol and parental
treatment of hemorrhoids in late pregnancy. Journal of
psychopathology. Pediatric Drugs 2009: 11: pp 22-25.
Obstetrics and Gynaecology Canada 2009: 31: pp 654-659.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 59
Yaghoobi M, Koren G, Nulman I: Challenges with diagnosing
Antidepressants in pregnancy and fetal outcome. Koren G,
colorectal cancer during pregnancy. Canadian Family Physician
Berrard A. RSQ/Counseil du Medicament du Quebec
2009: 55: pp 881-885.
($50,000/year 2006-2009)
Yazdani P, Motz M, Koren G: Estimating the neurocognitive
Biologically-based outcome predictors in Juvenile radiopathic
effects of an early intervention program for children with
arthritis. Rosenberg J, Koren G. Canadian Institutes of Health
prenatal alcohol exposure. Canadian Journal of Clinical
Research ($1,250,000 2007-2012)
Pharmacology 2009: 16(3): pp 453-459.
California Tobacco-Related Disease Research Program.
Zelner I, Shor S, Gareri J, Lynn H, Roukema H, Lum L, Eisinga K,
Passive exposure to tobacco smoke in children. Koren G,
Nulman I, Koren G: Universal screening for prenatal alcohol
Zakarian J. San Diego State University ($150,000 2008-2010)
exposure: A progress report of a pilot study in the region of
Grey Bruce, Ontario. Therapeutic Drug Monitoring 2010:
May 4 [Epub ahead of print].
Centre for the study of complex childhood diseases (CSCCD).
Post M, Koren G. Canadian Foundation for Innovation
($2,400,000 2007-2010)
Ziv O, Morales E, Song YK, Peng X, Odening KE, Buxton AE,
Karma A, Koren G, Choic BR: Origin of complex behavior of
Developing a national screening tool kit for those identified and
spatially discordant alternans in a transgenic rabbit model of
potentially affected by FASD. Koren G. Public Health Agency of
type 2 long QT syndrome. Journal of Physiology 2009: 587:
Canada ($708,000 2007-2012)
pp 4661-4680.
Drugs and human milk. Ito S. Canadian Institutes of Health
Book Chapters
Research ($376,323 2007-2010; $602,292 2010-2015)
Ito S, Brochet MS. Drug exposure during lacatation. In:
Compendium of Pharmaceuticals and Specialties (Clin-Info
Environmental Team Grant: Effects of brominated flame
Section). Canadian Parmacists Association, Ottawa, 2009.
retardants on reproductive health on development. Koren G,
Goodyer C. Canadian Institutes of Health Research
Funding
($2,500,000 2010-2015)
A program of health technology assessment in children:
Assessing the use of biologic response modifiers for juvenile
Baseline biomonitoring studies and a survey of child-youth
idiopathic arthritis and the use of TPMT genetic testing for
health as prerequisites to epidemiological studies to assess
predicting mercaptopurine doses in children with acute
the health risk of the Attawapiskat first nation and Walpole
lymphoblastic leukemia. Ito S, Unger W. Ministry of Health and
island first nation. Koren G, Bend J, Rieder M. First Nation &
Long-term Care Drug Innovation Fund ($308,150 2009-2010)
Inuit Branch ($249,000 2009-2010)
60
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Genotype specific approaches to therapy in childhood -
Population pharmacokinetics of benznidozole in children with
Canadian Pharmacogenomic Network for Drug Safety. Ito S.
Chagas disease. Bournissen F, Koren G. Thrasher Research
Canadian Institutes of Health Research ($105,000/year
Fund ($25,000 US 2008-2010)
2009-2014)
Pre-emptive use of diclectin. Koren G. Duchesnay Inc.
Hair cortisol as a biomarker of chronic HPA axis response
($135,000/year 2005 -2011)
to stress. Sanders A, Koren G. North Carolina Translational
and Clinical Science Institute ($9,270 US 2009-2010)
Studies on pregnancy exposure to medications and vaccines.
Koren G, Chambers C. Organization of Teratology Information
Neurodevelopment of children exposed in utero to
Services ($5,300,000 US 2004-2012)
chemotherapy for maternal breast cancer. Nulman I.
Canadian Breast Cancer Foundation ($436,257 2010-2012)
The association between fatty acid ethyl esters in meconium
and the diagnoses of FASD in an at-risk Canadian population.
Novel transcriptional control of human CYP3A. Ito S. Canadian
Nulman I. Canadian Foundation on Fetal Alcohol Research
Institutes of Health Research ($340,540 2007-2010)
($54,950 2008-2011)
Obstetric Pharmacology Research Network: An RCT of diclectin
The effect of supra-therapeutic doses of Diclectin on childтАЩs
for nausea and vomiting in pregnancy. Koren G. Duchesnay
neurodevelopment. Nulman I. Duchesnay Inc. ($487,600
Inc./National Institutes of Health ($9,200,000 2007-2010)
2005-2010)
Pain in preterm infants in development and effects. Grunan R,
The fetal safety of proctofoam. Koren G. Duchesnay Inc.
Koren G. National Institutes of Health ($1,304,369 2007-2012)
($79,000/year 2007-2010)
Pharmacokinetics of folate in pregnancy. Koren G.
The Ivey Chair in Molecular Toxicology. Koren G. Canadian
Duchesnay Inc. ($96,000/year 2006-2012)
Institutes of Health Research ($250,000/year 2004-2014)
Pilot Project - Diagnosis of FASD in children in the care of
The role of placenta in fetal toxicology. Koren G. Canadian
ChildrenтАЩs Aid Society of Toronto and Catholic ChildrenтАЩs Aid
Institutes of Health Research ($584,309 2007-2011)
Society. Nulman I. Mothercraft ($55,000/year 2009-2011)
Use of antidepressant medications during pregnancy and
lactation: Development of an evidence-based decision tool.
Grigoriadis S, Koren G. Ontario Ministry of Health and
Long-Term Care ($294,357 2009-2011)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 61
Division Head
Dr. Darcy Fehlings
Full-Time
Dr. Evdokia Anagnostou
Dr. Douglas Biggar
Dr.
Dr.
Dr.
Dr.
Dr.
Ryan Hung
Elizabeth Jimenez
Anne Kawamura
Alvin Loh
Laura McAdam
Dr.
Dr.
Dr.
Dr.
Dr.
Golda Milo-Manson
Angela Orsino
Wendy Roberts
Jay Rosenfield
Peter Rumney
Part-Time and/or
Community Physicians:
Dr. Paige Church
Dr. Janine Flanagan
Dr. Cynthia Goldfarb
Dr. Mark Handley-Derry
Dr. Carolyn Hunt
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Nicola Jones-Stokreef
Peggy Kirkpatrick
Donal OтАЩLeary
Anne Richards
Clive Schwartz
David Shawn
Diann Superina-Bell
Division of Developmental Paediatrics
Divisional Overview
Roberts W: Professional Award for Excellence in Research,
The Division of Developmental Paediatrics is situated at
Ontario Association on Developmental Disabilities Research
Holland Bloorview Kids Rehabilitation Hospital. The Division
Special Interest Group, 2010.
consists of full-time physicians as well as a community section
of developmental paediatricians. The main clinical focus of the
Roberts W: Power Teacher, Award for Outstanding
Division is on childhood developmental disorders, such as
Contributions to Postgraduate Teaching, Department of
cerebral palsy and autism spectrum disorders. In addition,
Paediatrics, University of Toronto, 2010.
there is a paediatric rehabilitation component with the
Publications
acquired brain injury and neuromuscular programs.
Berkel S, Marshal CR, Weiss B, Howe J, Roeth R, Moog U,
Within the Division, there is a strong commitment to education.
Endris V, Roberts SW, Szatmari P, Pinto D, Bonin M, Riess A,
Under the leadership of Dr. Anne Kawamura as program
Engels H, Sprengel R, Scherer SW, Rappold GA: Mutations in
director, the fully accredited subspecialty residency program
the SHANK2 synaptic scaffolding gene in autism spectrum
in developmental paediatrics is the largest in Canada. There is
disorder and mental retardation. Nature Genetics 2010: 42(6):
also a commitment to training paediatric, physiatry, and neurology
pp 489-491.
residents and medical students in applied childhood disability.
Birken C, Parkin P, To T, Wilkins R, Macarthur C: Neighbourhood
The Division members actively lead applied clinical research
socioeconomic status and homicides among children in urban
in childhood disability studies, in association with the Holland
Canada. Pediatrics 2009: 123: e815-e819.
Bloorview Research Institute led by Dr. Colin Macarthur.
Busing N, Slade S, Rosenfield J, Gold I, Maskill S: In the spirit
Honours and Awards
of flexner: Working toward a collective vision for the future of
Biggar D: Dr. David Green Award, Muscular Dystrophy Canada,
medical education in Canada. Academic Medicine 2010: 85(2):
July 2009.
pp 340-348.
Biggar D: Physiatry Residency Program, Best contribution to
Delgado M, Hirtz D, Aisen M, Ashwal S, Fehlings D,
the program quality, June 2010.
McLaughlin J, Morrison L, Shrader M, Tilton A, Vargus-Adams J:
Practice parameter: Pharmacologic treatment of spasticity in
Fehlings D: Top scientific poster, Annual Meeting for the
American Academy for CP and Developmental Medicine, 2009.
children and adolescents with cerebral palsy (an evidencebased review): Report of the Quality Standards Subcommittee
of the American Academy of Neurology and the Practice
Fehlings D: Honourary Member, European Academy of
Committee of the Child Neurology Society. Neurology 2010:
Childhood Disability, 2010.
74(4): pp 336-343.
McAdam L: Young Investigator Award, 38th Annual Meeting
Fehlings D, Novak I, Berweck S, Hoare B, Stott N, Russo R:
Child Neurology Society, 2009.
Botulinum toxin assessment, intervention and follow-up for
paediatric upper limb hypertonicity: International consensus
statement. European Journal of Neurology 2010: 17: pp 38-56.
Cross-Appointees/
Scientific Staff
Dr. Jessica Brian
Dr. Colin Macarthur
Dr. Patricia McKeever
Fellows
Dr. Ghassan Abu-Kuwaik
Dr. Michal Begin
Dr. Nirit Brosh-Katz
Dr. Melissa Carter
Dr. Andrea Garbutt
Dr. Joelene Huber
Dr. Sharon Smile
Dr. Elizabeth Young
Administrative Staff
Maureen Hodge
Barbara Zimnowodzki
Administrative Staff at
Bloorview Kids Rehab
Merlene Chin
Joanne Jenah
Romana Karnetova
Sharon Ouellette
Fernandez BA, Roberts SW, Chung B, Weksberg R, Meyn S,
Li W, Lam-Damji S, Chau T, Fehlings D: The development of a
Szatmari P, Joseph-George AM, Mackay S, Whitten K, Noble B,
home-based virtual reality therapy system to promote upper
Vardy C, Crosbie V, Luscombe S, Tucker E, Turner L, Marshall
extremity movement for children with hemiplegic cerebral
CR, Scherer SW: Phenotypic spectrum associated with de
palsy. Technology and Disability 2009: 21(3): pp 107-113.
novo and inherited deletions and duplications at 16p11.2
in individuals ascertained for diagnosis of autism spectrum
Mirenda P, Smith I, Vaillancourt T, Georgiades S, Duku E,
disorder. Journal of Medical Genetics 2009: 47(3): pp 195-203.
Szatmari P, Bryson S, Fombonne E, Roberts W, Volden J,
Gracies JM, Burke K, Clegg N, Browne R, Rushing C, Fehlings D,
Team: Validating the Repetitive Behavior Scale - Revised in
Matthews D, Tilton A, Delgado M: Reliability of the Tardieu
young children with autism spectrum disorder. Journal of
Waddell C, Zwaigenbaum L, and the Pathways in ASD Study
Scale for assessing spasticity in children with cerebral palsy.
Autism and Developmental Disorders 2010: April 20 [Epub
Archives of Physical Medicine and Rehabilitation 2010: 91(1):
ahead of print].
pp 421-428.
Rosenfield J: Commentary-interesting approach more research
Hollender E, Chaplin W, Soorya L, Wasserman S, Novotny S,
needed. International Journal of the Creative Arts in
Rusoff J, Feirsen N, Anagnostou E: Divalproex sodium vs.
Interdisciplinary Practice (on-line). Issue 8, Fall 2009.
placebo for the treatment of irritability in children and
adolescents with autism spectrum disorders.
Shen Y, Dies KA, Holm IA, Bridgemohan C, Sobeih MM,
Neuropsychopharmacology 2010: 35(4): pp 990-998.
Caronna EB, Miller KJ, Frazier JA, Silverstein I, Picker J,
Howard A, Macarthur C, Rothman L, Willan A, Macpherson A:
Brewster SJ, Kowalczyk SJ, Rosen-Sheidley B, McGowan C,
School playground surfacing and arm fractures in children: A
Duda AW 3rd, Lincoln SA, Lowe KR, Schonwald A, Robbins M,
cluster randomized trial comparing sand to wood chip surfaces.
Hisama F, Wolff R, Becker R, Nasir R, Urion DK, Milunsky JM,
Weissman L, Raffalli P, Jeste S, Demmer LA, Peters HK,
PLoS Medicine 2009: December 15 [Epub ahead of print].
Rappaport L, Gusella JF, Walsh CA, Wu BL, Miller DT: Autism
Consortium Clinical Genetics/DNA Diagnostics Collaboration:
Hung RM, Yoon G, Hawkins C, Halliday W, Biggar D, Vajsar J:
Clinical genetic testing for patients with autism spectrum
Cap myopathy caused by mutation of the skeletal alpha-actin
disorders. Pediatrics 2010: 125(4): e727-e735.
gene ACTA1. Neuromuscular Disorders 2010: 20: pp 238-240.
Sutcliffe TL, Logan WJ, Fehlings DL: Pediatric constraintJethwa A, Mink J, Macarthur C, Knights S, Fehlings T, Fehlings
induced movement therapy is associated with increased
D: Development of the Hypertonia Assessment Tool (HAT): A
contralateral cortical activity on functional magnetic resonance
discriminative tool for hypertonia in children. Developmental
imaging. Journal of Child Neurology 2009: 24(10):
Medicine and Child Neurology 2010: 52(5): pp e83-e87.
pp 1230-1235.
King BH, Hollander E, Sikick L, McCracken JT, Scahill L,
Young N, Rochon T, McCormick A, Law M, Wedge J, Fehlings D:
Gregman JD, Donnelly CL, Anagnostou E, Dukes K, Sullivan L,
The health and quality of life outcomes among youth and
Hirtz D, Wagner A, Ritz L, STAART Psychopharmacology
young adults with cerebral palsy. Archives of Physical Medicine
Network: Lack of efficacy of citalopram in children with autism
and Rehabilitation 2010: 91(1): pp 143-148.
spectrum disorders and high levels of repetitive behavior:
Citalopram ineffective in children with autism. Archives of
General Psychiatry 2009: 66(6): pp 583-590.
64
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Funding
Autism Intervention Research Network on Physical Health.
A longitudinal evaluation of the LIFEspan model of linked
Perrin J, Roberts W, Loh A. Autism Treatment Network,
healthcare. Macarthur C, Bayley M, Kingsnorth S, Maxwell J,
Massachusetts General Hospital ($400,882 2008-2011)
McKeever P, Lindsay S, Colantonio A, Hamdani S. Ontario
Neurotrauma Foundation ($307,608 2009-2013)
Autism Research Training (ART) program. Fombonne E, Bryson
S, Burack JA, Evans AC, Iarocci G, Mirenda P, Mottron L,
A molecular genetic study of autism and related phenotypes
Roberts SW, Rouleau GA, Scherer SW, Smith IM, Szatmari P,
in extended pedigrees. Szatmari P, Zwaigenbaum L, Scherer S,
Volden J, Zwaigenbaum L, Anagnostou E, Boyle M, Brian J,
Vincent J, Roberts SW, Goldberg J, Mahoney W, Fernandez B.
Couture M. Drapeau P, Enns J, Fahnestock M, Johnson S,
Canadian Institutes of Health Research ($550,000 2006-2011)
Kelley E, Kennedy T, Kingstone A, Mazer B, Moore C, Muckle G,
Nicholas D, Nicolson R, Paterson A, Tanaka J, Vaillancourt T,
A pilot dose finding study of pioglitazone in children with ASD.
Weksberg R. Canadian Institutes of Health Research
Anagnostou E, Brian J, Dupuis A. DeanтАЩs Fund ($10,000
($1,950,000 2009-2015)
2010-2011)
Autism spectrum disorders: Pathways to better outcomes
A pilot, randomized, placebo-controlled trial of omega-3 fatty
(Phase II). Szatmari P, Bryson SE, Fombonne E, Zwaigenbaum
acids in the treatment of young children with autism. Anagnostou E,
L, Smith I, Waddell C, Vaillancourt T, Mirenda P, Roberts W,
Roberts W, Brian J. ALVA Foundation ($150,000 2009-2012)
Volden J. Canadian Institutes of Health Research ($1,712,750
2009-2014)
A qualitative observational study of resident oral pediatric
developmental case presentations. Orsino A, Kawamura A,
Autism Treatment Network: Cooperative multi-centre program
Lingard L, Fehlings D. Bloorview Research Institute Seed
for research and treatment of autism. Roberts SW, Loh A,
Grant Competition ($10,552 2008-2009)
Feigenbaum A, Weiss S, Marcon C, Goldfarb C, Berall G,
Bradley E, Brian J, Freeman N. Atkinson A, Taylor M, Stinson J,
Active video games for promotion of physical activity in children
Mitchell S, Green P. Autism Speaks ($428,000 2008-2010)
and youth with disabilities: Risks and benefits. Biddiss E,
McKeever P, Wright V, Chau T, Fehlings D. Canadian Institutes
Biometric authentication using handwriting biomechanics.
of Health Research ($147,272 2010-2013)
Chau T, Anagnostou E, Fleury A. Natural Sciences and
An evaluation of the long-term effectiveness of botulinum toxin
2010-2013)
Engineering Research Council of Canada ($340,000
in children with spastic cerebral palsy. Fehlings D, Goldsmith C,
Narayanan U, Rosenbaum P, Wright W. Canadian Institutes of
Health Research ($442,307 2008-2012)
Canadian Injury Indicators Development, Phase II. Pike I,
Macpherson A, Macarthur C, Warda L, Babul S, Goodman D,
Raina P. Canadian Institutes of Health Research ($225,000
Autism comes to the hospital: Experiences of hospital care
2008-2011)
from the perspectives of children and adolescents with autism
spectrum disorder, their parents and health care providers.
ChildrenтАЩs, parentтАЩs and rehabilitation professionalsтАЩ beliefs
Muskat B, Nicholas D, Roberts SW, Stoddart K, Zwaigenbaum
regarding the value of walking: CIHR training grant in autism
L. SickKids Foundation and the Institute of Human
research. Fombonne E, Bryson S, Paterson A, Scherer S,
Development, Child and Youth Health - Canadian Institutes
Roberts W, Szatmari P, Smith I, Moore C. Canadian Institutes
of Health Research ($190,000 2010-2012)
of Health Research ($1,950,000 2009-2015)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 65
Development of an indicator of the impact of assistive devices
Functional outcomes following orthopaedic surgery based on
on children with disabilities and their families. Ryan S,
gait laboratory versus observational gait analysis in ambulatory
Campbell K, McKeever P, Montpetit K, Perkin S, Rigby P,
children with cerebral palsy: A multi-centre pilot randomized
Roxborough L, Stevens J. Canadian Institutes of Health
controlled trial. Narayanan U, Willan AR, Fehlings DL, Wedge JH,
Research ($225,000 2008-2011) and Bloorview Research
Zabjek KF. Canadian Institutes of Health Research ($314,633
Institute ($100,00 2008-2011)
2009-2013)
Discriminating autism from other atypical patterns of
Functional status outcome indicators for young children with
development in a community sample. Roncadin C, Roberts W,
cerebral palsy: Evaluation of the comparative abilities of two
Niccols A, Brian J, Bryson S, Smith I, Zwaigenbaum L. The
internationally-recognized measures to detect change, and
Ontario Mental Health Foundation (Type A Grant) ($142,005
determination of benchmarks for clinically important change.
2008-2010)
Wright V, Stratford P, Goldsmith C, Rigby P, Fehlings D,
Rosenbaum P. Canadian Institutes of Health Research
Dissociating cognitive and motor components of healthy and
($174,565 2008-2010)
dysfunctional expressive language development in children.
Pang E, Cheyne D, De Nil L, Roberts W. Canadian Institutes
of Health Research ($776,210 2008-2013)
Funding of an autism intervention research network for physical
health. Roberts SW, Loh A, Feigenbaum A, Weiss S, Marcon C,
Goldfarb C, Berall G, Bradley E, Brian J, Freeman N, Atkinson A,
Early developmental trajectories in autism. Zwaigenbaum L,
Taylor M, Stinson J, Mitchell S, Green P. Health Resources &
Bryson SE, Roberts S, Smith I, Szatmari P, Vaillancourt T.
Services Administration ($400,882 2009-2011)
Canadian Institutes of Health Research ($932,585 2006-2011)
Genome wide DNA methylation profiling in autism. Weksberg R,
Enhancing inter-subjectivity in infants at high-risk for autism.
Roberts SW, Scherer S. Canadian Institutes of Health
Bryson S, Brian J, Smith I, Zwaigenbaum L, Roberts SW.
Research ($649,518 2008-2011)
Autism Speaks Canada ($638,006 2007-2010)
Genomic influences on brain and behavioural trajectories in
Evaluating outcomes of hip interventions in children with
autism spectrum disorders. Zwaigenbaum L, Anagnostou E,
severe non-ambulatory cerebral palsy using the CPCHILD:
Scherer S, Evans A, Roberts W, Bryson S, Fombonne E,
A prospective cohort study. Narayanan U, Fehlings D, Weir S.
Mirenda P, Hall G, Szatmari P. NeuroDevNet ($2,643,200
Ontario Federation for Cerebral Palsy ($44,445 2010-2012)
2010-2013)
Evaluation of quality of movement in ambulatory children with
Greater outcomes for children impacted with severe
cerebral palsy: Validity and sensitivity to change of the quality
developmental disabilities and their families (GO4KIDDS).
FM. Rosenbaum P, Wright V, Mesterman R, Fehlings D, Kim M.
Perry A, Bebko J, Minnes P, Weiss J, Barrowman N,
Physicians Services Incorporated Foundation ($125,000
Condillac R, Dunn-Geier J, Isaacs B, Linblad T, Loh A,
2007-2009)
Nicolson R, Penn-Flanagan H. Canadian Institutes of
Health Research ($323,526 2009-2011)
Final stages of the development of the GMFM challenge
module: A new advanced motor skills test for children with
cerebral palsy. Wright V, Fehlings D. Physiotherapy Foundation
of Canada ($2,000 2010-2011)
66
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Health education and learning practices promoting social
School reintegration for children and youth with acquired
inclusion of children with developmental disabilities. Minnes P,
brain injury. Good D, Rumney P, MacDougall J, DeMatteo C,
Hutchinson N, Perry A, Isaacs B, Ouelette-Kuntz H, Loh A,
McKeever P, Guerriere D, Martinussen R, Kumpf J, Bennett S,
Cornish K, Dionne C, Nachshen J, Versnel J, Weiss J. Canadian
Loyst S. Ontario Neurotrauma Foundation ($348,400
Institutes of Health Research ($299,995 2009-2011)
2008-2010)
Implications for rehabilitation with children with cerebral palsy.
School, home and neighbourhood accessibility: Physically
Gibson B, Wright V, Fehlings D, McKeever P, Young N. Social
disabled childrenтАЩs assessments (The ScHaN Project).
Sciences and Humanities Research Services ($35,351
McKeever P, Ruddick S, Dunn J, Yantzi N, Young N, Doherty S.
2008-2009)
Canadian Institutes of Health Research ($360,768 2008-2011)
Improving early diagnosis and treatment for ASD: The Canadian
The efficacy of an intelligent prompting system to develop
Infant Sibling Project. Zwaigenbaum L, Brian J, Bryson S,
self-care activities in children with autism. Mihailidis A,
Szatmari P, Roberts W, Smith I. Autism Speaks Canada
Roberts SW, Polatajko H, Chau T. SickKids Foundation
($1,008,704 2010-2014)
($129,470 2007-2009)
Intranasal oxytocin for the treatment of children and
The experience of autism over the course of paediatric
adolescents with autism spectrum disorder (ASD). Anagnostou
development. Nicholas D, Roberts SW, McKeever P.
E, Roberts SW, Dupuis A, Jacob S, Cook E. Department of
SickKids Foundation ($95,996 2008-2010)
Defense ($805,791 2010-2013)
The genetic epidemiology of autism: Family and molecular
Long term follow-up of boys with Duchenne muscular dystrophy.
studies. Szatmari P, Zwaigenbaum L, Goldberg J, Bryson SE,
Biggar WD. Cooperative International Neuromuscular
Roberts SW, Patterson J, Mahoney A, Merette W, Tuff L,
Research Group ($6,000 2007-2012)
Vincent J, Scherer S. Canadian Institutes of Health Research
($779,731 2008-2013)
Memantine vs placebo for the treatment of motor skill deficits
for children with autism. Anagnostou E, Brian J, Roberts W,
The lived experience of mothers of children with autism.
Dupuis A, Loorya L, Bregman J. Autism Speaks ($200,000
Nicholas D, Roberts SW, McKeever P. Social Sciences and
2010-2012)
Humanities Research Council ($154,000 2008-2011)
Neurodevelopmental Network: National Centres of Excellence
Understanding early developmental trajectories in autism:
(NeuroDevNet NCE). Goldowitz D, Shevell M, Fehlings M,
From infancy to age 8. Zwaigenbaum L, Bryson S, Szatmari P,
Fehlings D, Limperopoulos C, Scherer S, Majnemer A, Yager J
Smith I, Roberts SW. Canadian Institutes of Health Research
(Cerebral Palsy Demonstration Project). Networks of Centres
($1,098,859 2010-2015)
of Excellence of Canada ($19,572,000 2010-2015)
Prevalence of creatine deficiency syndromes and genetic
variability in creatine metabolism in children with autism
spectrum disorder: A pilot study. Schulze A, Loh A, Scherer S,
Roberts W, Anagnostou E, Bauman M, Tsai A. Autism
Intervention Research Network on Physical Health,
Massachussetts General Hospital ($250,000 2009-2011)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 67
Division Head
Dr. Mark R. Palmert
Full-Time
Dr. Denis Daneman
Dr. Jill Hamilton
Dr.
Dr.
Dr.
Dr.
Farid Mahmud
Kusiel Perlman
Etienne Sochett
Diane Wherrett
Part-Time
Dr. Jacqueline Curtis
Dr. Susan Kirsch
Dr. Dror Koltin
Dr. Stacey Urbach
Gynaecology
Dr. Lisa Allen
Dr. Nicolette Caccia
Dr. Sari Kives
Dr. Alexandra Nevin-Lam
Dr. Melanie Ornstein
Dr. Rachel Spitzer
Cross-Appointees
Dr. Amira Klip
Dr. Joanne Rovet
Honourary
Dr. Robert Ehrlich
Division of Endocrinology
Divisional Overview
An important innovation this year was the launch of the
The past academic year was productive for the Division of
SickKids Team Obesity Management Program. STOMP is
Endocrinology with ongoing development of existing programs
an interdisciplinary medical-surgical program for obese
and new innovations. We continued our efforts to train future
children and youth. The program is intended for children and
endocrinologists from Canada and around the world. This year,
adolescents with complex, severe obesity defined as: greater
we had 10 trainees in our subspecialty training program: three
than the 99th percentile for BMI, or greater than the 95th with
Canadians, three Israelis, two Irish, one Kuwaiti and one German.
an associated severe medical or psychosocial co-morbidity or
additional chronic illness impacted by obesity (e.g. solid organ
Our areas of clinical focus continue to be: (i) Diabetes: our
transplant, brain tumour-related hypothalamic obesity). STOMP
comprehensive program provides ongoing care to more than
is an intensive two-year program focusing on healthy lifestyle
1,000 children and teens with diabetes, including a program for
psychoeducation and cognitive behavioural therapy with
comprehensive assessment and treatment of adolescents with
access to surgical intervention (lap band bariatric procedure).
chronically poor diabetes control. New programs for youth with
The interdisciplinary team consists of three physicians
type II diabetes and medication-induced diabetes are also
(endocrinology, general paediatrics and general surgery),
being developed; (ii) General Endocrinology: emphasizing the
an exercise therapist, psychologist, dietitian, social worker,
areas of growth, thyroid disease, disorders of sex development,
information coordinator and nurse practitioner.
pubertal disorders and reproductive health; (iii) Calcium: the
Calcium-Bone and Bone Health Clinics assess children with
Our research efforts have targeted the following areas: (i)
abnormal bone health from a wide variety of causes as part of
prediction and prevention of type 1 diabetes: our group is
the multidisciplinary Bone Health Centre; and (iv) Gynecology
involved in the multinational TrialNet and TRIGR study groups;
Section: provides care to pre-teen and adolescent girls across
(ii) implications and treatment of insulin resistance and obesity
a wide spectrum of disorders.
among children and adolescents and the evolution of these
abnormalities in young children; (iii) identification of factors
We continued to develop further our pathways for the care
affecting metabolic control and the early complications of
of children with thyroid cancer in collaboration with Oncology,
diabetes; (iv) psychosocial and psychological outcomes in
Otolaryngology and Nuclear Medicine; to enhance our program
diabetes and other endocrine disorders; (v) evaluation of
designed to provide care to survivors of paediatric cancer who
disorders of calcium and bone mineral metabolism in
develop endocrine abnormalities; and to develop further our
paediatrics; and (vi) clinical and laboratory-based investigation
obesity program.
of complex genetic traits, with an emphasis on identification
of genes that regulate the timing of puberty.
Subspecialty
Residents/Clinical
Fellows
Dr. Ereny Bassilious
Dr. Dror Koltin
Dr. Clodagh OтАЩGorman
Dr.
Dr.
Dr.
Dr.
Constantine Samaan
Rayzie Shulman
Jonathan Wasserman
Jonathan Yeshayahu
Fellows - Gynaecology
Dr. Erin Barlow
Research Fellow
Dr. Corinna Grasemann
Administrative Staff
Shahla Amiri
Elizabeth Rodgers
Minet Smith
Zarine Tilak
Melissa Warren
Honours and Awards
Aggarwal A, Lucco KL, Lacy J, Kives S, Gerstle JT, Allen L:
Barlow E, Allen L, Ornstein M (PI): 2nd place Paediatric
Ovarian epithelial tumors of low malignant potential: A case
Gynecology Oral Presentation, Society of Obstetrics &
series of 5 adolescent patients. Journal of Pediatric Surgery
Gynaecology, Montreal. Use of Levonorgestrel-releasing
2009: 44: pp 2023-2027.
intrauterine system for menstrual suppression in the
developmentally delayed adolescent, June 2010.
Aimone A, Vaughan J, Ward W, Jefferie A, Campbell DM,
Asztalos E, Feldman F, Rovet J, Westall C, Whyte H, OтАЩConnor
Daneman D: Frederick Kenny Visiting Lecturer, ChildrenтАЩs
DL: Growth and body composition of human mild-fed premature
Hospital/University of Pittsburgh.
infants provided with extra energy and nutrients early after
hospital discharge: One year follow-up. Journal of Pediatric
Daneman D: John F. Crigler Visiting Lecturer, Boston ChildrenтАЩs
Gastroenterology and Nutrition 2009: 49: pp 456-466.
Hospital/Harvard Medical School.
Al Abdulrazzaq D, OтАЩGorman C, Urbach S: Hypoglycemia and
Daneman D: ISPAD (International Society for Pediatric and
micropenis in the newborn - hormonal red flags. Paediatrics &
Adolescent Diabetes) Prize for Achievement.
Child Health 2009: 14: pp 453-456.
Daneman D: Alvin B Hayles Visiting Lecturer, Mayo Clinic
Allen L: Opinions in pediatric and adolescent gynecology:
Medical School.
Timing of gonadectomy: Opinion one: A case for delayed
gonadectomy. Journal of Pediatric and Adolescent Gynecology
Hamilton J: Hospital for Sick Children Foundation:
2009: 22(6): pp 381-384.
Humanitarian Award Nomination for Family Advisory Committee
Award, 2009 (nominated by patients and their families for
Allen LM, Lucco KL, Brown CM, Spitzer RF, Kives S: Psychosexual
providing family-centred care).
and functional outcomes after creation of a neovagina with
laparoscopic Davydov in patients with vaginal agenesis.
Hamilton J: POWER Teacher Award, Department of Pediatrics,
Fertility Sterility 2010: March 14 [Epub ahead of print].
University of Toronto: Outstanding Contributions to
Postgraduate Teaching, 2010.
Aman J, Skinner TC, de Beaufort CE, Swift PG, Aanstoot HJ,
Cameron F, Martul P, Chiarelli F, Daneman D, Danne T, Dorchy
Publications
H, Hoey H, Kaprio EA, Kaufman F, Kocova M, Mortensen HB,
AdDIT Research Group: The Adolescent Type 1 Diabetes
Nj├╕lstad PR, Phillip M, Robertson KJ, Schoenle EJ, Urakami T,
Cardio-Renal Intervention Trial. BioMed Central Paediatrics
Vanelli M, Skovlund S: Associations between physical activity,
2009: 9: p 79.
sedentary behavior, and glycemic control in a large cohort
of adolescents with type 1 diabetes: The Hvidoere Study
Afzal S, Wherrett D, Bartels U, Tabori U, Huang A, Stephens D
Group on Childhood Diabetes. Pediatric Diabetes 2009: 10:
and Bouffet E: Challenges in management of patients with
pp 234-239.
intracranial germ cell tumor and diabetes insipidus treated
with cisplatin and/or ifosfamide based chemotherapy.
Journal of Neuro-oncology 2009: 97(3): pp 393-399.
Amed S, Daneman D, Mahmud F, Hamilton J: Type 2 diabetes
in children and youth. Expert Review of Cardiovascular Therapy
2010: 8(3): pp 393-406.
70
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Amed S, Dean H, Panagiotopoulos C, Sellers E, Hadjiyannakis
Cherney DZI, Sochett EB, Lai V, Dekker MG, Slorach C,
S, Laubscher T, Dannenbaum D, Shah B, Booth G, Hamilton J:
Scholey JW, Bradley TJ: Renal hyperfiltration and arterial
National surveillance for non-type 1 diabetes mellitus in
stiffness in humans with uncomplicated type 1 diabetes
Canadian children: Type 2 diabetes, medication induced
mellitus. Diabetes Care 2010: June 28 [Epub ahead of print].
diabetes and monogenic diabetes. Diabetes Care 2010: 33(4):
pp 786-791.
Chiang CWK, Gajdos ZKZ, Korn JM, Kuruvilla FG, Butler JL,
Hackett R, Guiducci C, Nguyen T, Wilks R, Forrester T, Haiman
Avula S, Daneman A, Navarro O, Moineddin R, Urbach S,
CA, Henderson KD, Le Marchand L, Henderson BE, Palmert MR,
Daneman D: Incidental Thyroid abnormalities in children:
McKenzie CA, Lyon HN, Cooper RS, Zhu X, Hirschhorn JN:
Identified by neck ultrasound for ton-thyroid disorders.
Rapid assessment of genetic ancestry in populations of
Pediatric Radiology 2010: May 21 [Epub ahead of print].
unknown origin by genome-wide genotyping of pooled samples.
PLoS Genetics 2010: 5; 6(3): e1000866.
Badawi A, Klip A, Haddad P, Cole DEC, Bailo BG, El-Sohemy A,
Karmali M: Type 2 diabetes mellitus and inflammation:
Chiu TT, Patel N, Shaw AE, Bamburg JR, Klip A: Arp2/3- and
Prospects for biomarkers of risk and nutritional intervention.
cofilin-coordinated actin dynamics is required for insulin-
Diabetes, Metabolic Syndrome and Obesity: Targets and
mediated GLUT4 translocation to the surface of muscle cells.
Therapy 2010: 3: pp 173-186.
Molecular Biology of the Cell 2010: September 1 [Epub ahead
of print].
Bilan PJ, Samokhvalov V, Koshkina A, Schertzer JD, Samaan
CM, Klip A: Direct and macrophage-mediated actions of fatty
Clarson CL, Mahmud FH, Baker JE, Clark HE, McKay WM,
acids causing insulin resistance in muscle cells. Invited review.
Schauteet VD, Hill D: Metformin in combination with structured
Archives of Physiology and Biochemistry 2009: 115: 4:
lifestyle intervention improved body mass index in obese
pp 176-190.
adolescents, but did not improve insulin resistance.
Endocrinology 2009: 36(1): pp 141-146.
Bui H, To T, Stein R, Fung KW, Daneman D: Is diabetic
ketoacidosis at disease onset a result of missed diagnosis?
The Journal of Pediatrics 2010: 156(3): pp 472-477.
Contreras-Ferrat AE, Toro B, Bravo R, Parra V, V├бsquez C,
Ibarra C, Mears D, Chiong M, Jaimovich E, Klip A, Lavandero S:
An Inositol 1,4,5-Triphosphate (IP3) -IP3 receptor pathway
Cherney DZI, Miller JA, Scholey JW, Nasrallah R, H├йbert RL,
is required for Insulin-Stimulated Glucose Transporter 4
Dekker MG, Slorach C, Sochett EB, Bradley TJ: Renal
translocation and glucose uptake in cardiomyocytes.
hyperfiltration is a determinant of endothelial function
Endocrinology 2010: 151(10): August 4 [Epub ahead of print].
responses to cyclooxygenase 2 inhibition in type 1 diabetes.
Diabetes Care 2010: 33(6): pp 1344-1346.
Daneman D, Kennedy J, Coyte P: Evaluation of the Career
Development and Compensation Plan in the Department of
Cherney DZI, Reich HN, Miller JA, Lai V, Zinman B, Dekker MG,
Paediatrics at The Hospital for Sick Children. Healthcare
Bradley TJ, Scholey JW, Sochett EB: Age is a determinant of
Quarterly 2010: 13: pp 64-71.
acute hemodynamic responses to hyperglycemia and
angiotensin ii in humans with uncomplicated type 1 diabetes
mellitus. American Journal of Physiology: Regulatory, Integrative
and Comparative Physiology 2010: 299(1): pp R206-R214.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 71
Garin I, Edghill EL, Akerman I, Rubio-Cabezas O, Rica I, Locke JM,
Hartig SM, Ishikura S, Hicklen RS, Feng Y, Blanchard EG,
Maestro MA, Alshaikh A, Bundak R, del Castillo G, Deeb A,
Voelker KA, Pichot CS, Grange RW, Raphael RM, Klip A,
Deiss D, Fernandez JM, Godbole K, Hussain K, OтАЩConnell M,
Corey SJ: The F-BAR protein CIP4 promotes GLUT4 endocytosis
Klupa T, Kolouskova S, Mohsin F, Perlman K, Sumnik Z, Rial JM,
through bidirectional interactions with N-WASp and Dynamin-2.
Ugarte E, Vasanthi T; Neonatal Diabetes International Group,
Journal of Cell Science 2009: 122: pp 2283-2291.
Johnstone K, Flanagan SE, Mart├нnez R, Casta├▒o C, Patch AM,
Fern├бndez-Rebollo E, Raile K, Morgan N, Harries LW, Casta├▒o L,
Ishikura S, Antonescu CN, Klip A: Documenting GLUT4 Exocytosis
Ellard S, Ferrer J, Perez de Nanclares G, Hattersley AT
and endocytosis in muscle cell monolayers. Invited review.
Current Protocols in Cell Biology 2010: Unit 15.15: pp: 1-9.
Garin I, Edghill EL, Hattersley AT, Perlman K: Recessive
mutations in the INS gene result in neonatal diabetes through
Junqueira, B, Allen L, Spitzer R, Lucco K, Babyn P, Doria A:
reduced insulin biosynthesis. Proceedings of the National
Mullerian duct anomalies and mimics in children and
Academy of Sciences 2010: 107(7): pp 3105-3110.
adolescents: correlative intraoperative assessment with
clinical imaging. Radiographics 2009: 29(4): pp 1085-1103.
Gottlieb PA, Quinlan S, Krause-Steinrauf H, Greenbaum CJ,
Wilson DM, Rodriguez H, Schatz DA, Moran AM, Lachin JM,
Kewalramani G, Bilan PJ, Klip A: Muscle insulin resistance:
Skyler JS, for the Type 1 Diabetes TrialNet, MMF-DZB
assault by lipids, cytokines and local macrophages. Invited
Study Group: Failure to preserve beta-cell function with
Review. Current Opinions in Clinical Nutrition and Metabolic
mycophenolate mofetil and daclizumab combined therapy in
Care 2010: 13: pp 382-390.
patients with new- onset type 1 diabetes. Diabetes Care 2010:
33(4) pp 826-832.
Koontz MB, Cuttler L, Palmert MR, OтАЩRiordan MA, Borawski EA,
McConnell J, Kern EO: Development and validation of a
Greenbaum RG, Stevens S, Sheard E, Rovet J: Social cognitive
questionnaire to assess carbohydrate and insulin-dosing
and emotion processing abilities of children with fetal alcohol
knowledge in youth with type 1 diabetes. Diabetes Care 2010:
spectrum disorders: A comparison with attention deficit
33(3): pp 457-462.
hyperactivity disorder. Alcoholism, Clinical and Experimental
Research 2009: 33: pp 1656-1670.
Mabbott DJ, Rovet J, Noseworthy M, Smith ML, Rockel C:
The relations between white matter and declarative memory in
Guttmann A, Nakhla M, Henderson M, To T, Daneman D,
older children and adolescents. Brain Research 2009: 1294:
Cauch-Dudek K, And X, Lam H, Hux J: Validation of a Health
pp 80-90.
administrative data algorithm for assessing the epidemiology
of diabetes in Canadian children. Pediatric Diabetes 2010:
Mahmud FH, Hill D, Cuerdin M, Clarson CL: Impaired
11(2): pp 122-228.
endothelial function in obese adolescents with insulin
resistance. Journal of Pediatrics 2009: 155(5): pp 678-682.
Hamilton J, Odrobina E, Hanley A, Zinman B, Retnakaran R:
Effect of maternal insulin sensitivity during pregnancy on infant
Mahon JL, Sosenko JM, Rafkin-Mervis L, Krause-Steinrauf H,
weight gain and adiposity at 12 months of age. Obesity 2010:
Lachin JM, Thompson C, Bingley PJ, Bonifacio E, Palmer JP,
18(2): pp 340-346.
Eisenbarth GS, Wolfsdorf J, Skyler JS, and the Type 1 Diabetes
TrialNet Study Group: The TrialNet natural history study of the
development of Type 1 diabetes: Objectives, design, and
initial results. Pediatric Diabetes 2009: 10(2): pp 97-104.
72
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Nakhla M, Daneman D, To T, Paradis G, Guttmann A: Transition
Rakhshani N, Jeffery A, Schulte F, Barrera M, Atenafu E,
to adult care for youths with diabetes: Findings from a universal
Hamilton J: Evaluation of a comprehensive care clinic model
health care system. Pediatrics 2009: 124(6): pp 1134-1141.
for children with brain tumour and risk for hypothalamic
obesity. Obesity 2010: January 7 [Epub ahead of print].
Niu W, Bilan PJ, Ishikura S, Schertzer JD, Contreras-Ferrat A,
Fu Z, Liu J, Boguslavsky S, Foley KP, Liu Z, Li J, Chu G,
Retnakaran R, Qi Y, Goran M, Hamilton J: Evaluation of
Panakkezhum T, Lopaschuk GD, Lavandero S, Yao Z, Klip A:
proposed oral disposition index measures in relation to the
Contraction-related stimuli regulate GLUT4 traffic in C2C12-
actual disposition index. Diabetic Medicine 2009: 26(12):
GLUT4myc skeletal muscle cells. American Journal of
pp 1198-1203.
Physiology, Endocrinology and Metabolism 2010: 298:
pp e1058-e1071.
Rottembourg D, OтАЩGorman C, Urbach S, Garneau PY, Langer J,
Van Vliet G, Hamilton J, Huot C: Outcome after bariatric surgery
Nulman I, Rovet J, Barrera M, Knittel-Keren D, Feldman BM,
in two adolescents with hypothalamic obesity following
Koren G: Neurodevelopment of children exposed to maternal
treatment of craniopharyngioma. Journal of Pediatric
nausea and vomiting of pregnancy and diclectin. The Journal
Endocrinology and Metabolism 2009: 22(9): pp 867-872.
of Pediatrics 2009:155: pp 45-50.
Savasi I, Lacy JA, Gerstle JT, Stephens D, Kives S, Allen:
Obadia M, Rakhshani N, Jeffery A, Chahal N, Sangha G,
Management of ovarian dermoid cysts in the pediatric and
McCrindle B, OтАЩConnor D, Maccarone T, Hamilton J: MEALTRAIN:
adolescent population. Journal of Pediatric and Adolescent
What do in-patient hospitalized children choose to eat? The
Gynecology 2009: 22: pp 360-364.
Journal of Pediatrics 2010: 156(4): pp 685-686.
Schulte F, Bartels U, Bouffet E, Janzen L, Hamilton J,
OтАЩGorman C, Simoneau-Roy J, Pencharz P, MacFarlane J,
Barrera M: Body Weight, Cognitive Functioning and social
MacLusky I, Narang I, Adeli K, Daneman D, Hamilton J: Sleep
competence in survivors of childhood brain tumors.
disordered breathing is increased in obese adolescents with
Pediatric Blood & Cancer 2010: 55(3): pp 532-539.
craniopharyngioma compared with obese controls. The Journal
of Clinical Endocrinology and Metabolism 2010: 95(5):
Schwenk RW, Dirkx E, Coumans WA, Bonen A, Klip A, Glatz JFC,
pp 2211-2218.
Luiken JJFP: Requirement for distinct vesicle-associated
membrane proteins in insulin- and AMP-activated protein
OтАЩGorman C, Hamilton J, Rachmiel M, Gupta A, Ngan B,
kinase (AMPK) -induced translocation of GLUT4 and CD36
Daneman D: Differentiated thyroid cancer in childhood:
in cultured cardiomyocytes. Diabetologia 2010: 53(10):
A retrospective review. Thyroid 2010: 20(4): pp 375-380.
pp 2209-2219.
Pescovitz MD, Greenbaum CJ, Krause-Steinrauf H, Becker DJ,
Shao H, Sinasac D, Burrage LC, Hodges CA, Supelak PJ,
Gitelman SE, Goland R, Gottlieb PA, Marks JB, McGee PF,
Palmert MR, Moreno C, Cowley AW, Jacob HJ, and Nadeau JH:
Moran AM, Raskin P, Rodriguez H, Schatz D, Wherrett D,
Analyzing complex traits with congenic strains. Mammalian
Wilson DM, Lachin JM, Skyler JS and The Type 1 Diabetes
Genome 2010: 21(5-6): pp 276-286.
TrialNet Anti-CD20 Study Group: Rituximab, B-lymphocyte
depletion, and preservation of beta-cell function. New England
Shum AK, DeVoss J, Tan C, Hou Y, Johannes K, OтАЩGorman C,
Journal of Medicine 2009: 361(22): pp 2143-2152.
Jones KD, Sochett EB, Fong L, Anderson MS: Identification of
an autoantigen demonstrates a link between interstitial lung
disease and a defect in central tolerance. Science Translational
Medicine 2009: 1(9): p 9ra20.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 73
Simic N, Westall C, Asztalos E, Rovet J: Visual abilities at
Whittle W, Singh S, Allen L, Windrim R, Thomas J, Leyland N:
six-months in preterm infants: Impact of thyroid hormone
Laparoscopic Cervico-Isthmic Cerclage: surgical technique
deficiency and neonatal medical morbidity. Thyroid 2010:
and obstetric outcomes. American Journal of Obstetrics and
20: pp 309-315.
Gynecology 2009: 201(4): pp 364-367.
Sud S, Marcon M, Assor E, Palmert MR, Daneman D, and
Wolfsdorf J, Craig M, Daneman D, Dunger D, Edge J, Lee W,
Mahmud F: Celiac disease and pediatric type 1 diabetes:
Rosenbloom A, Sperling M, Hanas R: Diabetic Ketoacidosis:
Treatment dilemmas. International Journal of Pediatric
ISPAD Clinical Practice Guidelines. Pediatric Diabetes 2009:
Endocrinology 2010: June 23 [Epub ahead of print].
10(Suppl 12): pp 118-133.
Swift P, Skinner T, de Beaufort C, Cameron F, Aman J,
Yinon Y, Kingdom JC, Proctor LK, Kelly EN, Salle JL, Wherrett D,
Aanstoot HJ, Casta├▒o L, Chiarelli F, Daneman D, Danne T,
Keating S, Nevo O, Chitayat D: Hypospadias in males with
Dorchy H, Hoey H, Kaprio E, Kaufman F, Kocova M, Mortensen H,
intrauterine growth restriction due to placental insufficiency:
Nj├╕lstad P, Phillip M, Robertson K, Schoenle E, Urakami T,
The placental role in the embryogenesis of male external
Vanelli M, Ackermann R, Skovlund S, for the Hvidoere Study
genitalia. American Journal of Medical Genetics Part A 2009:
Group on Childhood Diabetes: Target setting in intensive insulin
152A(1): pp 75-83.
management is associated with metabolic control: The
Hvidoere Childhood Diabetes Study Group Centre Differences
Zhu H, Shah S, Ng SC, Einhorn W, Shinoda G, Viswanathan S,
Study 2005. Pediatric Diabetes 2010: 11(4): pp 271-278.
Takeuchi A, Grassemann C, Hirschhorn J, Palmert MR,
Szauter K, Ordas A, Laxer R, Pope E, Wherrett D, Alman B,
phenotypes identified in human genetic association studies.
Mink M, Boyd C, Csiszar K, Hinek A: A novel fibrotic disorder
Nature Genetics 2010: 42(7): pp 626-630.
Daley GQ: Lin28A transgenic mice manifest size and pubertal
associated with increased dermal fibroblast proliferation and
downregulation of genes of the microfibrillar network. British
Books and Book Chapters
Journal of Dermatology 2010: June 18 [Epub ahead of print].
Daneman D, Frank M, Perlman K: When a child has diabetes,
3rd Edition. Key Porter Books, Toronto, 2010.
TODAY Study Group: Design of a family-based lifestyle
intervention for youth with type 2 diabetes: The TODAY study.
Gupta S, Urbach SL. Endocrine complications. In: The Hospital
International Journal of Obesity (London) 2010: 34(2):
for Sick Children Handbook of Supportive Care in Pediatric
pp 217-226.
Oncology (Abla O, Dupuis L, Naqvi A, Truong T, Breakey V, eds.).
Jones & Bartlett, Sudbury, MA, 2009.
Van Eyk N, Allen L, Giesbrecht E, Jamieson MA, Kives S, Morris M,
Ornstein M, Fleming N: Pediatric vulvovaginal disorders: A
Perlman K. Management of diabetes mellitus in children and
diagnostic approach and review of the literature. Journal of
adolescents: In: Approach to the Management of Diabetes
Obstetrics and Gynaecology Canada 2009: 31: pp 850-862.
Mellitus. Banting and Best Diabetes Centre, Toronto, 2009.
Wherrett D, Daneman D: Prevention of type 1 diabetes.
Rovet J, Foley T, Nakhala M: Pediatric thyroid disease:
Endocrinology and Metabolism Clinics of North America 2009:
Hypothyroidism. In: Clinical Management of Thyroid Disease
38: pp 777-790.
(Wondisford F, Radovick S, eds.). Elsevier Press, New York, 2009.
74
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Shulman RM, Palmert MR, Wherrett D: Disorders of sex
Autonomic nervous system regulation in adolescents and
development. In: Fanaroff & MartinтАЩs Neonatal-Perinatal
children treated for craniopharyngioma. Hamilton J, McCrindle B,
Medicine, 8th Edition (Martin R, Fanaroff A, Walsh M, eds.).
Syme C. Brainchild Foundation ($20,632 2010-2012).
Elsevier, Philadelphia, 2010.
Bypassing insulin resistance of muscle cells caused by
Funding
ceramide, oxidative stress and macrophage-co-culture. Klip A.
Adolescent type 1 diabetes cardio-renal intervention trial
Canadian Diabetes Association ($300,000 2006-09)
(AdDIT). Daneman D. The Hospital for Sick Children
($91,020 2008-2012)
Brain function in FASD: Neuroanatomy of Memory Mapping,
Rovet J. Canadian Foundation for Fetal Alcohol Research
Adolescent diabetes intervention trial (AdDIT) (retinopathy and
($64,000 2008-2010)
cardiovascular). Daneman D, Curtis J, Mahmud F, Sochett E.
Canadian Diabetes Association ($85,000 2009-2012)
CASE Center for transdisciplinary research on energetics and
cancer: Determinants of obesity and metabolic dysfunction
Adolescent diabetes intervention trial (AdDIT). Daneman D,
in adolescents. Berger N, Redline S, Palmert MR. National
Sochett E, Curtis J, Mahmud F. Heart and Stroke Foundation
Institutes of Health/National Cancer Institute ($1,529,233
of Ontario ($363,577 2009-2012)
2005-2010)
Adolescent type 1 diabetes cardio-renal intervention trial
Comparison of continuous versus cyclical use of a 30-MCG
(AdDIT). Daneman D, Curtis J, Sochett S, Mahumd F. Juvenile
ethinyl estradiol 0.15 mg desogestrel oral contraceptive pill in
Diabetes Research Foundation ($383,504.80 US 2007-2012)
adolescents. Allen L, Brown C. Akzo Nobel тАУ Organon Canada
($24,500 2006-2011)
Adolescent type 1 diabetes cardio-renal intervention trial
(AdDIT). Daneman D, Curtis J, Sochett S, Mahumd F.
Comparison of continuous versus cyclical use of a 30-MCG
British Heart Foundation (┬г30, 400 2007-2012)
ethinyl estradiol 0.15 mg desogestrel oral contraceptive pill
in adolescents. Allen L, Brown C. PhysiciansтАЩ Services
An early developmental model of overeating, obesity and
Incorporated Foundation ($70,500 2006-2011)
executive dysfunction. Levitan R, Meany M, Davis C, Dub├й L,
Gruber R, Hamilton J, Kennedy J, Matthews S, Soares C,
DNA methylome study in type 1 diabetes. Petronis A, Palmert MR.
Steiner M. Canadian Institutes of Health Research ($763,130
National Institutes of Health/National Institute of Child
2010-2015)
Health and Human Development ($2,939,808 2009-2012)
A pilot prospective study of measurement of ovarian function
Exploring the mechanisms of risk for type 2 diabetes in
in adolescent females receiving cancer therapy. Gupta A,
adolescents. Hamilton J, OтАЩGorman C. Adrian and Rita Hudson
Lee-Chong A, Allen L, Kives S, Traubici J. Comprehensive
Fund at the Toronto Community Foundation ($38,611
Cancer Center Adolescent Transition Care Program
2009-2010)
Competition ($50,000, 2009-2010)
Gene by environment interactions that modulate pubertal
Assessment of health-related quality and life and anxiety in
timing. Palmert MR, Grasemann C. The Hospital for Sick
survivors of paediatric differentiated thyroid cancer. Hamilton J,
Children Research Training Centre ($80,000 2009-2010)
Dupuis M, Schulte F, Murphy A. SickKids Endocrine Research
Fund ($6,500 2009)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 75
Gene by Environment interactions that modulate pubertal
Intracellular compartment plasticity and signal transmission in
timing. Palmert MR, Wang M. Institute of Medical Science
insulin action. Klip A. Canadian Institutes of Health Research
Summer Undergraduate Student Research Award ($2,400
($759,560 2005-2010)
2009-2009)
Interplay between fatty acids and macrophages in the genesis
Genetic factors that regulate the onset of puberty. Palmert MR.
and relief of muscle cell insulin resistance Klip A. Canadian
National Institutes of Health/National Institute of Child
Diabetes Association ($255,000 2009-2012)
Health and Human Development ($1,633,256 2005-2010)
JDRF (Juvenile Diabetes Research Foundation) and Diabetes
Growth hormone therapy and bone quality in pediatric
UK (AdDIT) Study. Daneman D. Juvenile Diabetes Research
osteoporosis. Sochett E, Grynpas M. Eli Lilly Canada
Foundation and Diabetes UK ($85,000 2008-2012)
($125,000 2006-2009)
Mapping brain function in Fetal Alcohol Spectrum Disorders:
Hemodynamic modulation in type 1 diabetes. Miller J,
Neuroanatomy of memory. Rovet, J. Canadian Institutes of
Sochett E, Cherney D. Canadian Institutes of Health
Health Research ($100,000 2008-2010)
Research ($127,603.17 2007-2012)
Mobile phone-based self-management system for adolescents
High impact strategies towards overweight reduction in youth
with Type 1 diabetes mellitus: A home-based self-care tool that
(HISTORY). Determinants of metabolic risk in overweight
links the client and family with their health care team. Cafazzo J,
children and adolescents. Team Grant: McCrindle B, Hamilton J,
Palmert MR, Katzman D. Applied Client-Focused Team (ACT)
Parkin P, Pencharz P, Anderson G, Birken C, Wells G, Riddell M,
Grant, St. ElizabethтАЩs Care to Know Center ($119,000
Hanley A, OтАЩConnor D, Dettmer E, Bellissimo N, Langer J, Tein I,
2009-2010)
Mahmud FH, Narang I. Canadian Institutes of Health Research
($2,322,370 2008-2013)
Mouse model of in-utero hyperglycemia: Assessment of risks
for metabolic abnormalities in offspring. Palmert MR, Lee Y.
Impact of maternal metabolic abnormalities in pregnancy
Banting and Best Diabetes Centre, Charles Hollenburg
on breast milk composition and subsequent infant metabolic
Summer Studentship ($2,400 2009-2009)
development. OтАЩConnor DL, Ley S, Hanley T. Co-Applicant:
Hamilton J, Sermer M, Retnakaran R, Zinman B. Canadian
PROMOTE: Preschoolers at risk - obesity and cardiometabolic
Diabetes Association ($225,429 2009-2012)
risk factors: Towards early identification. Birken CS, Adeli K,
Hamilton J, Hanley A, Maguire J, McCrindle B, Parkin PC.
Insulin resistance and beta cell dysfunction in early childhood:
the role of maternal and infant metabolic risk factors. Hamilton
J, Retnakaran R, Hanley A, Zinman B. Canadian Institutes of
Health Research ($511,886 2008-2013)
76
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Canadian Institutes of Health Research ($100,000 2010-2011)
PROMOTE: Preschoolers at risk-obesity and cardiometabolic
The role of eyes and gaze in normal and abnormal social
risk factors: Towards early identification. Birken CS, Adeli K,
cognition development, Rovet J. Canadian Institutes of
Hamilton J, Hanley A, Maguire J, McCrindle B, Parkin PC:
Health Research ($100,000 2009-2011)
PhysiciansтАЩ Services Incorporated Foundation ($168,200
2010-2012)
Treatment Options for Type 2 Diabetes in Adolescents and
Youth (TODAY). Palmert MR, Dahms W. National Institutes
Regulation of muscle glucose transporters by Rac and
of Health/National Institute of Diabetes and Digestive
Rabs during insulin action and lipotoxicity. Klip A. Canadian
and Kidney Diseases ($3,240,000 2002-2010)
Institutes of Health Research ($724,217 2010-2015)
Type 1 Ddabetes genetics consortium. Wherrett DK. National
The comprehensive care clinic for children with central
Institutes of Health contract with Benaroya Research
tumours: Evaluating the efficacy of an integrated, multi-
Institute ($15,000 US 2004-2009)
disciplinary model of care for children with hypothalamic
dysfunction. Hamilton JK, Barrera M, Guger S, Popov T,
Type 1 Diabetes TrialNet Toronto Clinical Centre. Wherrett DK.
Schulte F. Brainchild Foundation ($27,931 2006-2009)
National Institutes of Health ($500,000 2009-2010)
The GH Monitor Registry. Hamilton J (Principal Investigator
Type 1 Diabetes TrialNet. Toronto Clinical Centre. Wherrett DK.
SickKids site). Serono Canada Incorporated (Funding is
National Institutes of Health ($2,100,000 + $100,000 per
distributed on a per patient basis) ($6,200 2005-2010)
year 2009-2014)
The GLUT4 interactomes and their metabolic implications.
Use of ACASI to gather information on risk behaviours in a
Klip A. Canadian Institutes of Health Research ($818,206
referral population of pregnant Canadian adolescents. Spitzer
2007-2012)
RF. PhysiciansтАЩ Services Incorporated Foundation ($37,800
2010-2012)
The impact of dietary factors on the pathophysiology of
gestational diabetes and subsequent type 2 diabetes.
Vitamin D supplementation and CD4 count in HIV-infected
Retnakaran R, Hanley AJ, Zinman B, Connelly PW, Sermer M,
children. Bitnun A, Read S, Kakalia S, Sochett E. Canadian
Hamilton JK. Canadian Diabetes Association ($272,590
Foundation for HIV/AIDS Research ($24,997 2008-2009)
2008-2011)
The prevalence of albuminuria in youth with type 2 diabetes.
Sellers E, Hadjiyannakis S, Hamilton J, Dean H, Amed S,
Panagiotopoulos D, Dyck R, Langlois V, Dart A. Public
Health Agency of Canada ($40,000 2010-2012)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 77
Division Head
Dr. Anne Griffiths
Full-Time
Dr. Yaron Avitzur
Dr. Peter Durie
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Nicola Jones
Binita Kamath
Simon Ling
Margaret Marcon
Aleixo Muise
Vicky Ng
Paul Pencharz
Dr. Philip Sherman
Dr. Thomas Walters
Dr. Stanley Zlotkin
Part-Time
Dr. Glenn Berall
Dr. Carol Durno
Dr. Paul Kortan
Dr. Gary May
Cross-Appointees
Dr. Latifa Yeung
Dr.
Dr.
Dr.
Dr.
Dr.
Maher Al-Hatlani
Marialena Mouzaki
Scott Nightingale
Christiane Sokollik
Johan Van Limbergen
Clinical Fellows
Research Fellows
Division of Gastroenterology, Hepatology & Nutrition
Divisional Overview
Divisional faculty conduct research which spans the spectrum
The Division of Gastroenterology, Hepatology and Nutrition
from basic and translational to patient-based in such areas
provides subspecialty clinical care to children and adolescents
as inflammatory bowel disease, exocrine pancreatic diseases,
with gastrointestinal, pancreatic, hepatologic and nutritional
liver diseases, GI microbiology and immunology, nutritional
disorders, including those who have undergone liver and/or
metabolism and nutrient requirements. Increasingly, faculty
small bowel transplantation. Clinical volumes and patient
collaborate in or lead large multi-centre research consortia
complexity have increased steadily, with busy in-patient,
addressing both pathogenesis and treatment of childhood liver
ambulatory and procedural practices. The year 2009-2010
disease, cystic fibrosis, and inflammatory bowel disease.
was one of change for the Division, marked by the appointment
of three new full-time faculty members. The Division welcomed
Honours and Awards
Dr. Yaron Avitzur, as Medical Director, Intestinal Failure and
Durie P: Henry Lynch Lifetime Achievement Award, Division
Transplant Program; Dr. Binita Kamath as a Clinician/
of Gastroenterology, Hepatology and Nutrition, University of
Investigator in the Hepatology program; Dr. Thomas Walters
Pittsburgh, 2010.
as Co-Director of the Inflammatory Bowel Diseases Program
and Director of Endoscopic Procedures.
Durie P: Physician Researcher Award for Research Excellence,
Department of Pediatrics, University of Toronto, 2010.
The Division is responsible for the University of Toronto
fellowship training program in Paediatric Gastroenterology,
Griffiths A: Richard Rowe Award for Clinical Excellence in
Hepatology and Nutrition, which has an international reputation
Paediatric Medical Care, Department of Pediatrics, 2010.
for training academic subspecialists. The program, which
usually accepts four new fellows annually, consists of one year
Sherman P: NASPGHAN Harry Shwachman Award, 2010.
of intensive clinical training and two or more years of training
in basic or clinical research. The clinical component includes
Walters T: The Dick Hamilton Award, Division of Gastroenterology,
training in endoscopic procedures, inpatient management of
Hepatology and Nutrition, The Hospital for Sick Children, 2009.
complex patients including those awaiting and undergoing liver
transplantation and those with inflammatory bowel disease;
Zlotkin SH: Danone Institute Distinguished Nutrition Leadership
ambulatory clinics (including general GI, IBD, hepatology,
Award, 2010.
transplantation, feeding disorders, and nutrition). To
complement their clinical or basic science research training,
Zlotkin SH: American Academy of Paediatrics Samuel J. Fomon
fellows are encouraged to complete a post-graduate degree
Nutrition Award, 2009.
(MSc or PhD) at either the Faculty of Health Promotion,
Management and Epidemiology (HPME) or the Institute for
Bandsma R: Canadian Institutes of Health Research Fellowship
Medical Sciences at the University of Toronto. The emphasis
Award, 2010.
placed on academic scholarly work during training is aimed
at preparing fellows for careers in academic paediatric
Bandsma R: Canadian Diabetes Association Fellowship, 2010.
gastroenterology both in Canada and around the world.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Fatma Al-Madhaki
Vishal Avinashi
Robert Bandsma
Eric Benchimol
Tanja Gonska
Seamus Hussey
Keith Ooi
Dr. Juan Ossa
Dr. Mary Sherlock
Dr. Catharine Walsh
Constance OтАЩConnor
Karen Frost
Kim Milbury
Nurse Practitioners
Maria DтАЩAngelis
Krista Murch
Ambulatory Nurses
Zenaida Chinea
Katherine Parker
Vikki Scaini
Alison Stewart
Julia Kelly
Debra Harrison
Administrative Staff
Chona Callejo
Tamara Forde
Roxanne Francis
Margaret Johnson
Sherry Joy
Nnenna Ngoka
Lilatool Shakur
Suzanne Shek
Bandsma R: Banting and Best Fellowship, 2010.
Publications
Allen U, Barton M, Beyene J, Hu P, Khodai-Booran N, Hebert D,
Benchimol E: Poster of Distinction, NASPGHAN Annual Meeting,
Dipchand A, Ng V, Solomon M, Grant D, Fecteau A, Ngan B,
National Harbor, MD, November 12-14, 2009).
Read S, Zielenska M, Weitzman S: Gene expression using
DNA Microarrays in transplant recipients at risk of EBV
Hussey S: Poster Distinction, Digestive Diseases Week,
lymphoproliferation after organ transplantation: Preliminary
New Orleans, LA, 2010.
proof of concept. Pediatric Transplantation 2009: 13:
pp 990-998.
Hussey S: The Dick Hamilton Award, The Dick Hamilton Award,
Division of Gastroenterology, Hepatology and Nutrition, 2010.
Anthony S, Pollock-BarZiv S, Ng VL: Quality of life after pediatric
solid organ transplantation. Pediatric Clinics of North America
Ooi K: Clinical Research Award, Research Day, Department
2010: 57(2): pp 559-574.
of Paediatrics, University of Toronto, Canada, 2010.
Ardelean DS, Gonska T, Wires S, Cutz E, Griffiths A, Harvey E,
Ooi K: Career Enhancement Award, Canadian Child Health
Tse S, Benseler S: Severe ulcerative colitis after rituximab
Clinician Scientist Program, 2009.
therapy in a pediatric patient. Paediatrics 2010: 126:
pp 243-246.
Sherlock M: Inflammatory Bowel Disease Fellowship тАУ awarded
by the Canadian Association of Gastroenterology/Canadian
Institutes of Health Reseach/UCB Pharma, 2010.
Avitzur Y, Grant D: Intestine transplantation in children тАУ
Update 2010. Pediatric Clinics of North America 2010: 57(2):
pp 415-431.
Walsh C: Canadian Child Health Clinician Scientist Program
Doctoral Award from the Canadian Institutes of Health
Bales CB, Kamath BM, Munoz PS, Nguyen A, Piccoli DA,
Research, 2009.
Spinner NB, Horn D, Shults J, Leonard M, Grimberg A,
Loomes KM. Pathologic lower extremity fractures in children
Walsh C: Department of Paediatrics Research Fellowship
with Alagille Syndrome. Journal of Pediatric Gastroenterology
Award, Hospital for Sick Children, 2009
and Nutrition 2010: May 4 [Epub ahead of print].
Walsh C: University of Toronto Standardized Patient ProgramтАЩs
Bartlett JR, Friedman KJ, Ling SC, Pace RG, Bell SC, Bourke B,
25th Anniversary Grant, 2010
Castaldo G, Castellani C, Cipolli M, Colombo C, Colombo JL,
Debray D, Fernandez A, Lacaille F, Macek Jr. M, Rowland M,
Walsh C: American Society for Gastrointestinal Endoscopy
Salvatore F, Taylor CJ, Wainwright C, Wilschanski M, Zemkov├б D,
Quality in Endoscopic Research Award, 2009.
Hannah WB, Phillips MJ, Corey M, Zielenski J, Dorfman R,
Wang Y, Zou F, Silverman LM, Drumm ML, Wright FA, Lange EM,
Walsh C: Network of Excellence in Simulation for Clinical Teaching
Durie PR, Knowles MR: Genetic modifiers of liver disease in
and Learning, Innovation and Evaluation Project Grant, 2009.
cystic fibrosis. Journal of the American Medical Association
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80
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Barton M, Wasfy S, Dipchand A, Hebert D, Ng V, Solomon M,
Carter-Kent C, Yerian LM, Brunt EM, Angulo P, Kohli R, Ling SC,
Fecteau A, Stephen D, Allen U: Seven-valent pneumococcal
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Yap J, Lopez R, McCullough AJ, Feldstein AE: Nonalcoholic
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Dorfman R, Li W, Sun L, Lin F, Wang Y, Sandford A, Par├й PD,
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Brant S, Dassopoulos T, McGovern D, Torres E, Duerr R,
Zielenski J, Strug LJ: Modifier gene study of meconium ileus
McKay K, Kayserova H, Piskackova T, Macek M, Czerska K,
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in cystic fibrosis: Statistical considerations and gene mapping
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results. Human Genetics 2009: 126: pp 763-778.
genotypic characteristics of inflammatory bowel disease in
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pp 464-473.
Abla O, Dror Y: Hepatitis-associated aplastic anemia presenting
as a familial bone marrow failure syndrome. Journal of Pediatric
Hematology and Oncology 2009: 31(11): pp 884-887.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 81
Dotson J, Hyams J, Markowitz J, LeLeiko N, Mack D, Evans J,
Hartman-Craven B, Christofides A, OтАЩConnor DL, Zlotkin S.
Pfefferkorn M, Griffiths AM, Otley A, Bousvaros A, Kugathasan S,
Relative bioavailability of iron and folic acid from a new
Rosh J, Keljo D, Carvalho J, Tomer G, Mamula P, Kay M,
powdered supplement compared to a traditional tablet in
Kerzner B, Oliva-Hemker M, Langton C, Crandall W: Extra-
pregnant women. BMC Pregnancy and Childbirth 2009: 9: p. 33.
intestinal manifestations of pediatric inflammatory bowel
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Hussey S, Travasso LH, Jones NL: Autophagy as an emerging
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Immunology 2009: 21: pp 233-241.
Durno C, Holter S, Sherman PM, Gallinger S: Gastrointestinal
Hyams JS, Lerer T, Griffiths A, Pfefferkorn M, Stephens M,
phenotype of germline biallelic mismatch repair gene mutations.
Evans J, Otley A, Carvalho R, Mack D, Bousvaros A, Rosh J,
American Journal of Gastroenterology 2010: June 8 [Epub
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Keljo D, LeLeiko N, Markowitz J, Pediatric Inflammatory Bowel
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El-Matary W, Vandermeer B, Griffiths AM: Methotrexate for
infliximab therapy in children with ulcerative colitis. American
maintenance of remission in ulcerative colitis. Cochrane
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Imielinski M, Baldassano R, Griffiths AM, Russell RK, Annese V,
Gana JC, Turner D, Roberts EA, Ling SC: Derivation of a clinical
Dubinski M, Kugathasan S, Bradfield J, Walters T, Sleiman P,
prediction rule for the non-invasive diagnosis of varices in
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Hakonarson H: Common variants at 16p11 implicate IL-27
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of Pediatric Gastroenterology and Nutrition 2010: 50(6):
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82
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Kamath BM, Munoz PS, Bab N, Baker A, Chen Z, Spinner NB,
Khambalia A, OтАЩConnor DL, Zlotkin S. Periconceptional iron
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Lan H, Xu W, Silverberg MS, Rotin D: Polymorphisms in E-cadherin
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DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 83
Ng VL, Feng S: Preface: Optimization of outcomes of children
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after solid organ transplantation. Pediatric Clinics of North
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84
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Toiviainen-Salo S, Durie PR, Numminen K, Heikkila P, Marttinen E,
Turner D, Holger JS, Griffith LE, Beaton DE, Griffiths AM,
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DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 85
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86
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
A multi-center group to study acute liver failure in children.
Calcineurin inhibitor minimization and Foxp3+ Tregs post
Squires R, Ng V, Avitzur Y. National Institutes of Health
transplant. Hancock J, Kamath B. National Institutes
($10,800 US 2005-2010)
of Health/National Institute of Diabetes and Digestive
and Kidney Diseases ($25,000/year 2009-2011)
A multi-disciplinary human study on the genetic, environmental
and microbial interactions that cause IBD. Croitoru K, Griffiths AM,
Can SMOFlipid┬о, a composite parenteral nutrition lipid
Ropelski M, Moyeddi P. CrohnтАЩs and Colitis Foundation
emulsion, prevent progression of parenteral nutrition
of Canada ($5,600,000 2007-2012)
associated liver disease in infants with short bowel syndrome?
A pilot double blind randomized controlled trial. Wales P,
A prospective study of linear growth in paediatric IBD.
Pencharz P, Ling SC, Moore A, Feldman B, Diamond I.
Denson LA, Griffiths AM. CrohnтАЩs and Colitis Foundation
Investigator Initiated Research Funding, Fresnius Kabi,
of America ($150,000/year 2007-2010)
Germany ($162,500 2009-2011)
A randomized, double-blind, placebo controlled, multiple dose
Cell signaling in mucosal inflammation and pain. Ellen R,
study of VX-809 to evaluate safety, phamacokinetics and
McCullough C, Sherman PM. Canadian Institutes for
pharmacodynamics of VX-809 in Cystic Fibrosis subjects
Health Research ($325,000/year 2009-2015)
homozygous for the deltaF508-CFTR gene mutation. Durie P.
Vertex Pharmaceuticals, Inc. ($80,000 US 2009-2010)
Childhood Liver Disease and Research Network (ChiLDREN)
Consortium. Sokol R, Kamath B. National Institutes of Health/
A study of late rejection and medication non-adherence and
National Institute of Diabetes and Digestive and Kidney
after pediatric multi-organ transplantation. Pollock-BarZiv S,
Diseases ($146,076/year 2009-2014)
Ng V, Dipchand A, Solomon M, Hebert D. Astellas InvestigatorInitiated Study Grant ($25,000 2009-2010)
Childhood Liver Disease and Research Network (ChiLDREN)
Consortium. Sokol R, Ng V, Avitzur Y. National Institutes of
Adalimumab in pediatric CrohnтАЩs disease: A multicentre study.
Health ($146,620 2009-2010)
Griffiths AM. Abbott Laboratories (per patient remuneration;
anticipated $90,000 2007-2009)
Childhood Liver Disease and Research Network (ChiLDREN)
Consortium. Sokol R, Ng V, Kamath B, Ling S, Avitzur Y, Durie P,
Adherent and invading Escherichia coli engagement of
Chung C, Fecteau A. National Institutes of Health ($146,000
CEA-CAM6: Defining the link to CrohnтАЩs disease. Gray-Owen S,
2009-2010)
Sherman PM. CrohnтАЩs and Colitis Foundation of Canada
тАЬFederated Health Charities Legacy GrantтАЭ ($445,500
Clinical Research Facilitation Award. Durie P. Cystic Fibrosis
2008-2011)
Foundation Therapeutics, Inc. ($108,637 US/year 2007-2010)
Autism Treatment Network: Cooperative multi-center program
Constipation and toilet training in autism. Marcon M, Green P,
for research and treatment of autism. Roberts SW, Loh A,
Barreria L, Moroz L, Brian J. ATN AIRтАРP funding, Surrey Place
Feigenbaum A, Weiss S, Marcon M, Goldfarb C, Berall G,
Centre ($39,783 2010-2011)
Bradley E, Brian J, Freeman N. Atkinson A, Taylor M, Stinson J,
Mitchell S, Green P. Autism Speaks ($408,000 2008-2010)
Development and validation of an objective skill assessment
tool for colonoscopy. Walsh C, Carnahan H, Ling SC, Khanna N,
Walters T, Rabeneck L, Reznick R. American Society for
Gastrointestinal Endoscopy (ASGE) Quality in Endoscopy
Research Award Application ($75,000 2009-2010)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 87
Development and validation of an objective skill assessment
Health status of 10 year survivors of pediatric liver
tool for colonoscopy. Ling SC, Walsh C, Carnahan H.
transplantation: Review of a multi-center experience. Ng V,
Paediatric Consultants Grant ($4,968 2007-2011)
Bucuvalas J. National Institutes of Health Administrative
Supplement ($7,500 US 2010)
Development of a new sweat test using sweat potential
measurements. Durie P. Cystic Fibrosis Foundation
Immune regulation and biomarker development in pediatric and
Therapeutics, Inc. ($70,818 US/year 2008-2010)
adult onset human autoimmune diseases. Bar-Or A, Banwell B,
Diagnosing Cystic Fibrosis in neonates and adults: Where
Institutes of Health Research Team Grant ($2,018,445
do we draw the line? Durie P, Tullis E, Ratjen F. Canadian
2007-2112)
Piccirillo CA, Polychronakos C, Sherman PM. Canadian
Cystic Fibrosis Foundation ($120,000/year 2008-2011)
Infliximab in pediatric ulcerative colitis: A multicentre study.
Early predictors of outcome of biliary atresia. Nightingale S,
Griffiths AM. Centocor (per patient remuneration; anticipated
Ng VL. The Royal Australasian College of Physicians ($5,000
$100,000 2007-2009)
2009-2010)
Iron and malaria. Zlotkin S. National Institutes of Health
Effect of expert versus peer (intra-professional versus
($365,000 US/year 2009-2011)
inter-professional) feedback on the acquisition of urinary
catheterization skills. Walsh C, Carnahan H, Dubrowski A,
Molecular phenotypes for cystic fibrosis lung disease.
Backstein D, Ling SC, Rose D. Network of Excellence in
Knowles M, Durie P. National Institutes of Health
Simulation for Clinical Teaching and Learning Innovation
($60,000 US/year 2008-2010)
and Evaluation Projects Grant ($24,743 2009-2010)
Non-invasive diagnosis of esophageal varices in children.
Epithelial cell signaling responses to attaching-effacing
Ling S, Avitzur Y. Canadian Institutes of Health Research,
intestinal pathogens. Sherman PM. Canadian Institutes
Synthesis Grant: Knowledge Translation ($68,865
of Health Research ($752,500 2008-2013)
2008-2009)
Functional outcomes after pediatric liver transplantation. Ng V,
Non-invasive tests for the diagnosis of esophageal varices.
Fecteau A. National Institutes of Health ($3,000 US 2009-2010)
Ling SC, Gana JC, Garcia-Tsao G, Turner D. Canadian Institutes
of Health Research Synthesis Grant: Knowledge Translation
Funding of an autism intervention research network for physical
($68,865 2008-2010)
health (AIR-P). Roberts SW, Loh A, Feigenbaum A, Weiss S,
Marcon M, Goldfarb C, Berall G, Bradley E, Brian J, Freeman N,
Outcomes in severe pediatric ulcerative colitis: A multicenter
Atkinson A, Taylor M, Stinson J, Mitchell S, Green P. Health
study. Griffiths AM. Schering Canada ($350,000 2007-2009)
Resources and Services Administration ($400,882 2009-2011)
Pathobiology and ribosomal insufficiency in ShwachmanGenetic predictors of time to recurrence following ileal
Diamond syndrome. Rommens J, Durie P. Canadian Institutes
resection in early onset Crohn disease. McLeod R, Griffiths AM.
of Health Research ($124,238/year 2010-2015)
CrohnтАЩs and Colitis Foundation of Canada ($150,000/year
2007-2010)
Post-operative recurrence in paediatric Crohn Disease:
The influence of molecular factors. McLeod R, Silverberg M,
Griffiths AM, Walters TD. CrohnтАЩs & Colitis Foundation of
Canada Grant in Aid ($100,000/year 2007-2010)
88
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Prediction by ultrasound of the risk of hepatic cirrhosis
The contribution of genetic modulators of disease severity in
in cystic fibrosis (тАШPUSHтАЩ). Ling SC, Durie P, Navarro O.
cystic fibrosis to other diseases with similarities of clinical
Cystic Fibrosis Foundation/National Institutes of Health
phenotype. Durie P, Zielenski J. Genome Canada ($5,787,662
($333,000 2009-2013)
2005-2010)
Protocol AI463-08 тАЬEvaluation of the pharmacokinetics, safety,
The impact of an intestinal rehabilitation program on the
tolerability and efficacy of entecavir (ETV) in pediatric subjects
intestine transplant waiting list. Avitzur Y, Wang J. University
with chronic hepatitis B virus (HBV) infection who are HBeAg
of TorontoтАЩs Comprehensive Research Experience for
positiveтАЭ. Ling SC. Bristol-Myers Squibb ($25,000/patient
Medical Students Grant ($2,750 2010)
2007-2013)
The role of adherens junction protein in IBD. Muise A. CrohnтАЩs
Risk stratification and identification of immunogenetic and
and Colitis Foundation of Canada/ Canadian Association of
microbial markers of CD. Kugathasan S, PRO-KIIDS Consortium,
Gastroenterology/Canadian Institutes of Health Research
Walters TD. ChronтАЩs and Colitis Foundation of Canada Special
($115,000/year 2008-2012)
Purpose Grant ($1,000,000/year 2009-2012)
The role of CrohnтАЩs disease genes in intestinal failure and
Role of ATG16L1 in Crohn disease. Jones NL. CrohnтАЩs and
allograft rejection. Muise A, Avitzur Y. The Hospital for Sick
Colitis Foundation of Canada ($150,000/year 2008-2011)
Children, Transplant Center Grant ($12,500 2009-2010)
Role of autophagy during H. pylori infection and disease.
The role of NADPH oxidases in CrohnтАЩs disease. Jbrumell J,
Jones NL. Canadian Institutes of Health Research
Muise A. Canadian Institutes of Health Research ($192,840/
($103,575/year 2008-2013)
year 2009-2014)
Role of probiotics in the management of experimental
Therapeutic biomaterials for regenerative medicine. Sefton M,
inflammatory bowel disease. Sherman PM. CrohnтАЩs and
Sherman PM. Ontario Research Fund & Rimon Therapeutics
Colitis Foundation of Canada тАЬFay Shapiro Cutler
Inc. ($6,500,000 2009-2014)
Grant-In-Aid of ResearchтАЭ ($375,000 2007-2010)
Tier 1 (renewal). Sherman PM. Canada Research Chair
Sprinkles project support. Zlotkin S. HJ Heinz Company
($1,400,000 2008-2015)
Foundation ($300,000 US/year 2008-2009)
Understanding the genes involved in Inflammatory Bowel
Studies of Pediatric Liver Transplantation (SPLIT). Liver
Disease. Muise A. Ontario Ministry of Research and
transplantation in Alagille syndrome. Kamath B. National
Innovation ($25,000/year 2009-2014)
Institutes of Health/National Institute of Diabetes and
Digestive and Kidney Diseases ($7,500 2010-2010)
Studies of the proteins involved in Inflammatory Bowel Disease.
Muise A. Canadian Child Health Clinician Scientist Program
($5,000/year 2008-2012)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 89
Division Head
Dr. Victor Blanchette
Full-Time Faculty
Dr. Oussama Abla
Dr. Sarah Alexander
Dr. Ute Bartels
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Sylvain Baruchel
Eric Bouffet
Leonardo Brand├гo
Manuel Carcao
Helen Chan
John Doyle
Yigal Dror
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Adam Gassas
Ron Grant
Abha Gupta
Johann Hitzler
Annie Huang
Meredith Irwin
Walter Kahr
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Melanie Kirby
David Malkin
Ahmed Naqvi
Paul Nathan
Isaac Odame
Angela Punnett
Tal Schechter-Finkelstein
Dr.
Dr.
Dr.
Dr.
Lillian Sung
Uri Tabori
Sheila Weitzman
Suzan Williams
Division of Haematology/Oncology
Divisional Overview
paediatric oncology Phase I Consortium of COG (Principal
The Division of Haematology/Oncology provides a diagnostic
Investigator, Dr. Sylvain Baruchel) and an active participant in
service and specialist care for children under 18 with cancer
activities of the Soci├йt├й Internationale dтАЩOncologie P├йdiatrique
(paediatric oncology) and non-malignant blood disorders
(SIOP), the Histiocyte Society and the Berlin Frankfurt Munster
(paediatric haematology). The Division is the largest of its kind
(BFM) paediatric leukemia clinical trials group. The Division,
in Canada and among the largest of such programs worldwide.
in collaboration with the Pediatric Oncology Group of Ontario
Approximately 300 new cancer cases are registered in the
(POGO), supports a network of paediatric oncology satellite
paediatric oncology program each year, and the Division is the
centres in the Greater Toronto and surrounding areas. Satellite
designated centre for haematopoietic stem cell transplantation
centres in sickle cell disease are established in Rouge Valley
for patients under 18 years of age in the Province of Ontario.
hospital and William Osler Health Centre. Major achievements
The majority of the approximate 100 transplants performed
in the past year included the introduction of family-centred
each year are for children with cancer; fewer are performed for
patient rounds on the in-patient haematology/ oncology units
children with severe immunodeficiency disorders or genetic
and the establishment of an out-patient haematology/oncology
diseases. The number of in-patient days for paediatric
day hospital.
haematology/oncology cases is approximately 15,000/year
and the number of ambulatory care visits just over 20,000.
The Division is the largest Royal College of Physicians and
Reflecting the size and diversity of its clinical services, the
specialty paediatric haematology/oncology in Canada. The
Division is organized into six sections and three programs:
DivisionтАЩs Training Program Director is Dr. Angela Punnett.
the leukemia/lymphoma section (Section Head, Dr. Sheila
The Education Program in the Division also includes a large
Surgeons of Canada-accredited training program for the
Weitzman); the solid tumour section (Section Head, Dr. Ron
international training program in paediatric haematology/
Grant); the neurooncology (brain tumour) section (Section
oncology and offers subspecialty training opportunities in
Head, Dr. Eric Bouffet); the blood and marrow transplantation
areas such as paediatric leukemias/lymphomas,
section (Section Head, Dr. John Doyle); the haematology
neurooncology, cancer genetics, blood and marrow
section (Section Head, Dr. Victor Blanchette); the in-patient
transplantation and paediatric thrombosis and hemostasis.
services section (Section Head, Dr. Sarah Alexander); the
long-term follow-up (Aftercare) program (Program Head,
Research in the Division spans basic science to clinical care
Dr. Mark Greenberg); the new agents and innovative therapies
with a special focus on translational research. Approximately
program (Program Head, Dr. Sylvain Baruchel); and the cancer
one-half of the DivisionтАЩs 29 full-time faculty have appointments
genetics program (Program Head, Dr. David Malkin). The
as clinician scientists or clinician investigators in the
Haematology section has large programs in paediatric
Department of Paediatrics with parallel appointments in
thrombosis and hemostasis, the paediatric hemoglobinopathies
SickKids Research Institute. Research in the Division is
and the inherited and acquired paediatric marrow failure
multidisciplinary, involving health-care professionals with
syndromes and myelodysplasias. The Division is an active
expertise in a variety of areas (e.g. nursing, psychology, social
member of the ChilDr.enтАЩs Oncology Group (COG), the largest
work, pharmacy). The Division is committed to facilitating
paediatric cancer clinical trials group in North America
knowledge exchange through international partnerships with a
(SickKids Principal Investigator, Dr. Ron Grant), and is
particular focus on countries lacking the health-care resources
committed to the improvement in outcomes and quality of life
available in Canada. The Comprehensive Cancer Centre, with
in children with cancer through participation in ethics-approved,
its focus on promoting excellence across the spectrum of
prospective clinical trials. The Division is a member of the
clinical care, education and research related to paediatric
cancer, completed a successful second year.
Cross-Appointees/
Part-Time
Dr. Stephen Comay
Dr. Lee Ann Gallant
Dr. Mark Greenberg
Dr. David Hodgson
Dr.
Dr.
Dr.
Dr.
Dr.
Nicole Inch
Normand Laperriere
Barbara-Ann Millar
Aubrey Maze
Jill Solomon
Clinical and
Research Fellows
Dr. F. Al-Abbas
Dr. S. Al-Afghani
Dr. A. Al-Anazi
Dr. R. Al-Mahmoud
Dr. A. Almanea
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
O. Al-Sharif
Q. Alharbi
M. Ali
P. Angelini
K. Ashraf
M. Asim
L. Avila
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
J. Baker
W. Ballourah
B. Boonyawat
V. Breakey
P. Gibson
S. Gupta
A. Kassam
This year marked the end of the term of Dr. Victor Blanchette
Publications
as Division Head. Following an external review of the Division
Abla O, Weitzman S, Egeler RM: Langerhans cell histiocytosis:
and an international search, Dr. Jim Whitlock was appointed
Current concepts and treatments. Cancer Treatment Review
as the new Chief of the combined Division of Haematology/
2010: 36: pp 354-359.
Oncology. Dr. Whitlock is an internationally acclaimed
paediatric haematologist/oncologist with a special interest in
Adamiewicz TV, Abboud MR, Paler C, Olivieri N, Kirby M,
paediatric leukemias/lymphomas, the histiocytic disorders of
Vinchinsky E, Casella JF, Alvarez OA, Barredo JC, Lee MT,
children and paediatric cancer clinical trials. The administrative
Iyer RV, Kutlar A, McKie V, Odo N, Gee B, Kwiatkowski JL,
team for the Division comprises the Division Head, Judy van
Woods GM, Coates T, Wang W, Adams RJ: Serum ferritin level
Clieaf (Director, Child Health Services) and Lucy Holford
changes in children with sickle cell disease on chronic blood
(Administrator, Administrative and Support Services).
transfusion are non-linear, and are associated with iron
load and liver injury. Blood 2009: 114: pp 4632-4638.
Honours and Awards
Bartels U: Junior Faculty Award for Clinical Excellence in
Afzal S, Ethier MC, Dupuis LL, Tang L, Punnett AS,
Paediatric Medical Care, Hospital for Sick Children, 2009.
Richardson S, Allen U, Abla O, Sung L: Risk factors for
infection-related outcomes during induction therapy for
childhood acute lymphoblastic leukemia. Pediatric
Baruchel S: L├йgion dтАЩhonneur, France, 2010.
Infectious Diseases 2009: 28: pp 1064-1068.
Chan H: Order of Ontario, 2009.
Afzal S, Wherrett D, Bartels U, Tabori U, Huang A, Stephens D,
Punnett A: Families as Partners in Patient Safety Award,
Bouffet E: Challenges in management of patients with
Hospital for Sick Children, 2010.
intracranial germ cell tumour and diabetes insipidus treated
Punnett A: RHA Haslam Preclerkship Teaching Award, 2010.
Journal of Neuro-Oncology 2010: 97: pp 393-396.
Punnett A: Alvin Zipursky Teaching Award, Division of
Allen U, Barton M, Beyene J, Hu P, Khodai-Booran N, Hebert D,
Haematology/Oncology, Hospital for Sick Children, 2010.
Dipchand A, Ng V, Solomon M, Grant D, Fecteau A, Ngan B,
with cisplatin and/or ifosfamide based chemotherapy.
Read S, Zielenska M, Weitzman S: Gene expression
Sung L: William E. Rawls Award in Cancer Control, Canadian
using microarrays in transplant recipients at risk of EBV
lymphoproliferation after organ transplantation: Preliminary
Cancer Society, 2009.
proof-of-concept. Pediatric Transplantation 2009: 13: pp 990-998.
Sung L: POWER Teaching Award, The Hospital for Sick Children,
Angelini P, Hawkins C, Laperriere N, Bouffet E, Bartels U:
2010.
Post mortem examinations in pontine glioma: Challenges
Tabori U: Eureka! International Course of Translational
and chances. Journal of Neuro-Oncology 2010: May 16
Medicine Award, 2010.
[Epub ahead of print].
Weitzman S: Excellence in Postgraduate Medical Education
Angelini P, Kavadas F, Sharma N, Richardson SE, Tipples G,
Roifman C, Dror Y, Nofech-Mozes Y: Aplastic anemia following
Award, University of Toronto, 2010.
varicella vaccine. Pediatric Infectious Disease 2009: 28:
pp 746-748.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
A. Lee Chong
S. Leucht
O. Mosleh
R. Naithani
K. Phuakpet
C. Segbefia
F. Shaikh
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
E. Simpson
O. Teuffel
K. Thom
V. van Eimeren
K. Weingarten
B. Williams
P. Wong
Dr. N. Zhukova
Dr. A. Zorzi
Administrative Staff
Rhonda Adams
Bibi Ali
Ingrid Argiropoulos
Barbara Black
Enda Brennan
Sandra Carbone-Walker
Connie Grillo
Lucy Holford
Tiffany Jiminez
Shanaz Karim
Philippa McCaffrey
Kathleen Meliton
Sylvia Muir
Annabel Sousa
Arlene Zalzibar
Athale U, Duckworth J, Odame I, Barr R: Childhood atypical
Bjorkman S, Blanchette VS, Fischer K, Oh M, Spotts G, Schroth P,
teratoid rhabdoid tumor of the central nervous system:
Fritsch S, Patrone L, Ewenstein BM, for the ADVATE Clinical
Analysis of observational studies. Pediatric Hematology
Program Group, Collins PW: Comparative pharmacokinetics of
Oncology 2009: 31: pp 651-663.
plasma- and albumin-free recombinant factor VIII in children
and adults: the influence of blood sampling schedule on
Baruchel S, Sharp JR, Bartels U, Hukin J, Odame I, Portwine C,
observed age-related differences and implications for dose
Strother D, Freyer C, Halton J, Egorin MJ, Reis RM, Mathinho O,
tailoring. Thrombosis and Haemostasis 2010: 8: pp 730-736.
Stempak D, Hawkins C, Gammon J, Bouffet E: A Canadian
paediatric brain tumour consortium (CPBTC) phase II
Blanchette V, Bolton-Maggs P: Childhood immune
molecularly targeted study of imatinib in recurrent and
thrombocytopenic purpura: diagnosis and management.
refractory paediatric central nervous system tumours.
Hematology/Oncology Clinics of North America 2010: 24:
European Journal of Cancer 2009: 45: pp 2352-2359.
pp 249-273.
Beaumont M, Odame I, Babyn PS, Vidarsson L, Kirby MA,
Blanchette VS, Manco-Johnson MJ: Meeting unmet needs
Cheng MHL: Accurate liver T2 measurement of iron overload:
in inhibitor patients. Haemophilia 2010: 16: pp 46-51.
A simulations investigation and in-vivo study. Magnetic
Resonance Imagining 2009: 30: pp 313-320.
Bogue CO, Leahy TR, Rea DJ, Bitnun A, Brandao L, Kahr WH,
Jacobson S, Amaral JG, Connoly BL: Idiopathic suppurative
Beyene J, Atenafu EG, Hamid JS, To T, Sung L: Determining
pylephlebitis: Interventional radiological diagnosis and
relative importance of variables in developing and validating
management. Cardiovascular and Interventional Radiology
predictive models. BMC Medical Research Methodology
2009: 32: pp 1304-1307.
2009: 9: pp 64.
Bonilla M, Rossell N, Salaverria C, Gupta S, Barr R,
Biss TT, Blanchette VS, Clark DS, Wakefield CD, James PD,
Sala A, Metzger ML, Sung L: Prevalence and predictors of
Rand ML: Use of a quantitative pediatric bleeding questionnaire
abandonment of therapy among children with cancer in
to assess mucocutaneous bleeding symptoms in children with
El Salvador. International Journal of Cancer 2009: 125:
a platelet function disorder. Thrombosis and Haemostasis
pp 2144-2146.
2010: March 17 [Epub ahead of print].
Bouffet E: The role of myeloablative chemotherapy with
Biss T, Brand├гo L, Kahr W, Castle D, Williams S: The use of
autologous hematopoietic cell rescue in central nervous
elastic compression stockings for post-thrombotic syndrome
system germ cell tumors. Pediatric Blood and Cancer 2010:
in a child. Pediatric Blood and Cancer 2009: 53: pp 462-463.
54: pp 644-646.
Biss TT, Brand├гo LR, Kahr WHA, Chan AKC, Williams S: Clinical
Bouffet E, Tabori U, Huang A, Bartels U: Ependymoma:
probability score and D-dimer estimation lack utility in the
Lessons from the past, prospects for the future. ChildтАЩs
diagnosis of childhood pulmonary embolism. Thrombosis and
Nervous System 2009: 25: pp 1383-1384.
Haemostasis 2009: 7: pp 1633-1638.
Bouffet E, Tabori U, Huang A, Bartels U: Possibilities of new
therapeutic strategies in brain tumors. Cancer Treatment
Reviews 2010: 36: pp 335-341.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 93
Breakey VR, Blanchette VS, Bolton-Maggs PH: Towards
Dimaras H, H├йon E, Budning A, Doyle JJ, Halliday W, Gallie BL,
comprehensive care in transition for young people with
Chan HSL: Retinoblastoma CSF metastasis cured by
haemophilia. Haemophilia 2010: May 12 [Epub ahead of print].
multimodality chemotherapy without radiation. Ophthalmic
Genetics 2009: 30: pp 121-126.
Breakey VR, Meyn S, Ng V, Allen C, Dokal I, Lansdorp P, Abla O,
Dror Y: Hepatitis-associated aplastic anemia presenting as a
Dimaras H, Khetan V, Halliday W, H├йon E, Chan HSL, Gallie BL:
familial bone marrow failure syndrome. Pediatric Hematology
Retinoma underlying retinoblastoma revealed after tumor
Oncology 2009: 31: pp 884-887.
response to one cycle of chemotherapy. Archives of
Ophthalmology 2009: 127: pp 1066-1067.
Carcao M: Side effects and venous access issues with immune
tolerance therapy. Haemophilia 2009: 15: pp 494-500.
Dimaras H, Rushlow D, Halliday W, Doyle JJ, Babyn P,
Abella EM, Williams J, H├йon E, Gallie BL, Chan HS: Using RB1
Carcao M, Chambost H, Ljung R: Best practice prophylaxis in
mutations to assess minimal residual disease in metastatic
boys with severe haemophilia: Evaluation of current treatment
retinoblastoma. Translational Research 2010: 156: pp 91-97.
strategies. Hemophilia 2010: 16: pp 4-9.
Dix DB, Klassen AF, Papsdorf M, Klaassen RJ, Pritchard S,
Carcao M, Lambert T: Prophylaxis in haemophilia with
Sung L: Factors affecting the delivery of family-centered care
inhibitors: Update from international experience. Hemophilia
in pediatric oncology. Pediatric Blood and Cancer 2009: 53:
2010: 16: pp 16-23.
pp 1079-1085.
Carcao MD, Seary ME, Casas M, Winter L, Stain AM, Judd P:
Dunkel IJ, Chan HSL, Jubran R, Chantada GL, Goldman S,
Dental disease in Type 3 Von Willebrand disease: A neglected
Chintagumpala M, Khakoo Y, Abramson DH: High-dose
problem. Haemophilia 2010: June 20 [Epub ahead of print].
chemotherapy with autologous hematopoietic stem cell rescue
Chen J, Li Y, Doedens M, Wang P, Shago M, Dick J, Hitzler J:
55: pp 149-152.
for stage 4b retinoblastoma. Pediatric Blood and Cancer 2010:
Functional differences between myeloid leukemiaтАУinitiating and
transient leukemia cells in Down syndrome. Leukemia 2010:
Dupuis LL, Milne-Wren C, Cassidy M, Barrera M, Portwine C,
24: pp 1012-1017.
Johnston DL, Silva MP, Sibbald C, Leaker M, Routh S, Sung L:
Chong AL, Ngan BY, Weitzman S, Abla O: Anaplastic large cell
The parentsтАЩ perspective. Supportive Care Cancer 2009: 18:
lymphoma of the ovary in a pediatric patient. Journal of
pp 281-299.
Symptom assessment in children receiving cancer therapy:
Pediatric Hematology Oncology 2009: 31: pp 702-704.
Dupuis LL, Nathan PC: Optimizing emetic control in children
Chung JKH, Irwin MS: Chemosensitivity and the p53 family
receiving antineoplastic therapy: Beyond the guidelines.
network: triple threat? Current Drug Targets 2010: March 18
Pediatric Drugs 2010: 12: pp 51-61.
[Epub ahead of print].
Durbin AD, Hannigan GE, Malkin D: Oncogenic ILK: Tumor
Collins PW, Bjorkman S, Fischer K, Blanchette V, Oh M,
suppression and all that JNK. Cell Cycle 2009: 8: pp
Schroth P, Fritsch S, Casey K, Spotts G, Ewenstein BM:
4060-4066.
Factor VIII requirement to maintain a target plasma level in the
prophylactic treatment of severe haemophilia A: Influences of
Fadoo Z, Belgaumi A, Alam M, Azam I, Naqvi A: Pediatric
variance in pharmacokinetics and treatment regimens. Journal
lymphoma: A 10-year experience at a tertiary care hospital
of Thrombosis and Haemostasis 2010: 8: pp 269-275.
in Pakistan. Journal of Pediatric Hematology Oncology 2010:
32: pp 14-18.
94
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Finkelstein Y, Nava-Ocampo A, Schechter T, St. Pierre E,
Ginsberg JP, Aplenc R, McDonough J, Bethel J, Doyle J,
Goldman RD, Walker S, Koren G: Discrepancy in
Weiner DJ: Pre-transplant lung function is predictive of
pharmacokinetic analysis results by two standard population
survival following paediatric bone marrow transplantation.
pharmacokinetic software programs. Fundamental Clinical
Paediatric Blood & Cancer 2010: 54: pp 454-460.
Pharmacology 2009: 23: pp 53-57.
Goldsby RE, Lui Q, Nathan PC, Bowers DC, Yeaton-Massey A,
Finkelstein Y, Schechter T, Freedman SB: N95 vs. surgical
Raber SH, Hill D, Armstrong GT, Yasui Y, Zeltzer L, Robison LL,
mask protection against H1N1 virus. Journal of American
Packer RJ: Late occurring neurologic sequelae in adult
Medical Association 2010: 303: p 938.
survivors of childhood acute lymphoblastic leukemia: A report
from the Childhood Cancer Survivor Study. Journal of Clinical
Finkelstein-Schechter T, Gassas A, Mabbott D, Huang A,
Oncology 2010: 28: pp 324-331.
Bartels U, Tabori U, Janzen L, Hawkins C, Taylor M, Bouffet E:
Atypical teratoid/rhabdoid tumors: Improved outcome with high
Gray TL, Ooi CY, Tran D, Traubici J, Gerstle JT, Sung L:
dose chemotherapy. Journal of Pediatric Hematology Oncology
Gastrointestinal complications in children with acute myeloid
2010: 32: e182-e186.
leukemia. Leukemia and Lymphoma 2010: 51: pp 768-777.
Fouladkou F, Lu C, Jiang C, Zhou L, She Y, Walls JR, Kawabe H,
Gruenwald CE, Manlhiot C, Crawford-Lean L, Foreman C,
Brose N, Henkelman RM, Huang A, Bruneau BG, Rotin D:
Brand├гo LR, McCrindle BW, Holtby H, Richards R, Moriarty H,
The ubiquitin ligase Nedd4-1 is required for heart development
Van Arsdell G, Chan AK: Management and monitoring of
and is a suppressor of Thrombospondin-1. Journal Biological
anticoagulation for children undergoing cardiopulmonary
Chemistry 2010: 285: pp 6770-6780.
bypass in cardiac surgery. Journal Extra-Corporeal Technology
2010: 42: pp 9-19.
Frange P, Alapetite C, Gaboriaud G, Bours D, Zucker JM,
Zerah M, Brisse H, Chevignard M, Mosseri V, Bouffet E,
Gross T, Savoldo B, Punnett A: PTLD following pediatric solid
Doz F: From childhood to adulthood: Long-term outcome of
organ transplantation. Pediatric Clinics of North America 2010:
medulloblastoma patients. The Institut Curie experience
57: pp 481-504.
(1980-2000). Journal of Neurooncology 2009: 95: pp 271-279.
Gupta AA, Pappo A, Saunders N, Hopyan S, Ferguson P,
Gallie BL, Gronsdahl P, Dimaras H, Weizblit N, Astle W,
Wunder J, OтАЩSullivan B, Catton C, Greenberg M, Blackstein M:
Bendali N, Bhal A, Bowles E, Budning A, Carret AS, Chan HSL,
Clinical outcome of children and adults with localized Ewing
Chudley A, Clark I, Crooks B, Downie R, Erraguntla V, Green J,
sarcoma: Impact of chemotherapy dose and timing of local
Halliday W, Hamel P, H├йon E, Hope G, Ingram A, LaRoche R,
therapy. Cancer 2010: 116: pp 3189-3194.
Leat S, Livingstone M, Mallipatna A, McKay J, Paton K,
Robitaille J, Scott Lane L, Strahlendorf C, Superstein R,
Gupta S, Weitzman S: Primary and secondary hemophagocytic
Sutherland J, Ulster A, Valenzuela A, and Vasquez LM: National
lymphohistocytosis: Clinical features, pathogenesis and
Retinoblastoma Strategy Canadian Guidelines For Care.
therapy. Expert Review Clinical Immunology 2010: 6: pp
Canadian Journal of Ophthalmology 2009: 44: pp S1-S88.
137-154.
Gassas A, Zaidman I, Schechter T, Doyle J: Beyond
gastrointestinal graft-versus-host disease: A lesson to learn.
Paediatric Transplant 2010: April 13 [Epub ahead of print].
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 95
Halton, J, Gaboury I, Grant RM, Alos N, Cummings EA,
Jacob K, Albrecht S, Sollier C, Faury D, Sader E, Montpetit A,
Matzinger M, Shenouda N, Lentle B, Abish S, Atkinson S,
Serre D, Hauser P, Garami M, Bognar L, Hanzely Z, Montes JL,
Cairney E, Dix D, Israels S, Stephure D, Wilson B, Hay J,
Atkinson J, Farmer JP, Bouffet E, Hawkins C, Tabori U,
Moher D, Rauch F, Siminoski K, Ward LM: Advanced vertebral
Jabado N: Duplication of 7q34 is specific to juvenile pilocytic
fracture among newly diagnosed children with acute
astrocytomas and a hallmark of cerebellar and optic pathway
lymphoblastic leukemia: Results of the Canadian steroid-
tumours. British Journal of Cancer 2009: 101: pp 722-733.
associated osteoporosis in the pediatric population (STOPP)
research program. Journal of Bone and Mineral Research
2009: 24: pp 1326-1334.
Jhas S, Henriques L, Hawkins C, Bouffet E, Rutka JT: An
intracranial leiomyosarcoma in a child with neurofibromatosis
type 1. Canadian Journal of Neurological Science 2009: 36:
Hartley JL, Zachos NC, Dawood B, Donowitz M, Forman J,
pp 491-495.
Pollitt RJ, Morgan NV, Tee L, Gissen P, Kahr WH, Knisely AS,
Watson S, Chitayat D, Booth IW, Protheroe S, Murphy S,
Johnston DL, Keene D, Bartels U, Carret AS, Crooks B,
de Vries E, Kelly DA, Maher ER: Mutations in TTC37 cause
Eisenstat D, Fyer C, Lafay-Cousin L, Larouche V, Moghrabi A,
trichohepatoenteric syndrome (phenotypic diarrhea of infancy).
Wilson B, Zelcer S, Silva M, Brossard J, Bouffet E:
Gastroenterology 2010: 138: pp 2388-2398.
Medulloblastoma in children under the age of three years: A
retrospective Canadian review. Journal of Neurooncology 2009:
Hendershot E, Chang A, Colapinto K, Gerstle JT, Malkin D,
94: pp 51-56.
Sung L: Postoperative fevers in pediatric solid tumor patients:
How should they be managed? Journal of Pediatric
Johnston DL, Keene D, Bartels U, Carret AS, Crooks B,
Hematology/Oncology 2009: 31: pp 485-488.
Eisenstat D, Fryer C, Lafay-Cousin L, Larounch V, Moghrabi A,
Wilson B, Zelcer S, Silva M, Brossard J, Bouffet E: Patterns of
Inparajah M, Wong C, Sibbald C, Boodham S, Atenafu E,
enrollment of infants with central nervous system tumours on
Naqvi A, Dupuis L: Once daily Gentamicin dosing guidelines in
cooperative group studies: a report from the Canadian Brain
febrile neutropenic children. Pharmacotherapy 2010: 30: pp 43-51.
Tumour Consortium. Journal of Neurooncology 2010: February 5
[Epub ahead of print].
Iorio A, Halimeh S, Holzhauer S, Goldenberg N, Marchesini E,
Marcucci M, Young G, Bidlingmaier C, Brandao L,
Kahr WHA: Granules and thrombus formation. Blood 2009:
Ettingshausen E, Gringeri A, Kenet G, Knofler R, Kreuz W,
114: pp 932-933.
Kurnik K, Manner D, Santagostino E, Mannucci PM, NowakGottl U: Rate of inhibitor development in previously untreated
Kahr WHA, Savoia A, Pluthero FG, Li L, Christensen H,
hemophilia A patients treated with plasma-derived or
De Rocco D, Traivaree C, Butchart SE, Curtin J, Stollar EJ,
recombinant factor VIII concentrates: A systematic review.
Forman-Kay JD, Blanchette VS: Megakaryocyte and platelet
Journal Thrombosis Haemostasis 2010: 8: pp 1256-1265.
abnormalities in a patient with a W33C mutation in the
Ishaqi MK, Jamil A, Khanani M, Baroudi M, Trad O, El-Hayek M,
Thrombosis Haemostasis 2009: 102: pp 1241-1250.
conserved SH3-like domain of myosin heavy chain IIA.
Bouffet E: Hepatic sinusoidal obstruction syndrome in a
child after chemotherapy for medulloblastoma. Journal of
Kassam A, Chan AK, Dzolganovski B, Constantin J, Ramphal R,
Neurooncology 2010: 97: pp 137-141.
Grant RM, Sung L: No association between protein C levels
and bacteremia in children with febrile neutropenia. Journal
of Pediatric Hematology/Oncology 2009: 31: pp 647-650.
96
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Kenet G, Lutkhoff LK, Albisetti M, Bernard T, Bonduel M,
Lafay-Cousin L, Gupta A, Taylor M, Halliday W, Spiegler B,
Brandao L, Chabrier S, Chan A, deVeber G, Fiedler B, Fullerton
Huang A, Tabori U, Greenberg M, Weitzman S, Bouffet E:
HJ, Goldenberg NA, Grabowski E, Gunther G, Heller C,
Use if ICE chemotherapy in choroid plexus carcinoma.
Holzhauer S, Iorio A, Journeycake J, Junker R. Kirkham FJ,
Journal of Neurosurgery 2010: 5: pp 615-621.
Kurnik K, Lynch JK, Male C, Manco-Johnson M, Mesters R,
Monagle P, van Ommen CH, Raffini L Rostasy K, Simioni P,
Lam C, Bouffet E, Bartels U: Nimotuzumab in pediatric glioma.
Strater RD, Young G, Nowak-Gottl U: Impact of thrombophilia
Future Oncology 2009: 5: pp 1349-1361.
on risk of arterial ischemic stroke or cerebral sinovenous
thrombosis in neonates and children: A systematic review and
Lam C, Bouffet E, Tabori U, Mabbott D, Taylor M, Bartels U:
meta-analysis of observational studies. Circulation 2010: 121:
Rapamycin (sirolimus) in tuberous sclerosis associated
pp 1838-1847.
pediatric central nervous system tumors. Pediatric Blood
and Cancer 2010: 54: pp 476-479.
Khan U, Bogue C, Ungar W, Hilliard P, Carcao M, Moineddin R,
Doria A: Cost effectiveness analysis of different imaging
Laverdiere C, Liu Q, Yasui Y, Nathan PC, Gurney JG, Stovall M,
strategies for diagnosis of hemophilic arthropathy. Hemophilia
Diller LR, Cheung N, Wolden S, Robison LL, Sklar CA: Long-
2010: 16: pp 322-332.
term outcomes in survivors of neuroblastoma: a report from
Klaassen RJ, Krahn M, Gaboury I, Barr RD, Hughes J, Rogers P,
Cancer Institute 2009: 101: pp 1131-1140.
the Childhood Cancer Survivor Study. Journal of the National
Anderson R, Whitehead M, Ali SK, Yanofsky R, Jardin L, Abla O,
Silva M, Carret AS, Barnard D, Cappelli M: Nurses provide
Leahy TR, Punnett AS, Richardson WE, Gharabaghi F,
valuable proxy assessment of health-related quality of life in
Wadhwa A: Molecular identification of phaeohyphomycosis
children with Hodgkin disease. Cancer 2010: 116: pp 1602-1607.
due to alternaria infectoria in a patient with acute myeloid
Klaassen RJ, Krahn M, Gaboury I, Hughes J, Anderson R,
Disease 2010: 66: pp 318-321.
leukemia - a case report. Diagnostic Microbiology Infectious
Grundy P, Ali SK, Jardin L, Abla O, Silva M, Barnard D, Cappelli
M: Evaluating the ability to detect change of health-related
Lee Chong A, Ngan B, Weitzman S, Abla O: Anaplastic large
quality of life in children with Hodgkin disease. Cancer 2010:
cell lymphoma of the ovary in a child. Journal of Pediatric
116: pp 1608-1614.
Hematology/Oncology 2009: 31: pp 702-704.
Klintman J, Berntorp E, Astermark J: MIBS Study Group:
Lee C, Ratnapalan S, Thompson M, Nathan P, Closs J, French A,
Thrombin generation in vitro in the presence of by-passing
Punnett A, Garcia-Bournissen F, Ito S, Koren G: Unusual
agents in siblings with severe haemophilia A. Haemophilia
reactions to 5-HT3 receptor antagonists in a child with
2010: 16: pp 210-215.
rhabdomyosarcoma. Canadian Journal Clinical Pharmacology
2010: 17: pp e1-e4.
Lafay-Cousin L, Bouffet E, Hawkins C, Amid A, Huang A,
Mabbott DJ: Impact of radiation avoidance on survival
Lehrnbecher T, Ethier M, Zaoutis T, Creutzig U, Gamis A,
and neurocognitive outcome in infant medulloblastoma.
Reinhardt D, Aplenc R, Sung L: International variations in
Current Oncology 2009: 16: pp 21-28.
infection supportive care practices for pediatric patients with
acute myeloid leukemia. British Journal of Haematology 2009:
147: pp 125-128.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 97
Li M, Lee KF, Lu Y, Clarke I, Shih D, Eberhart C, Collins VP,
Manlhiot C, Pollock-Barziv SM, Holmes C, Weitzman S, Allen U,
Van Meter T, Picard D, Zhou L, Boutros PC, Modena P, Liang ML,
Clarizia NA, Ngan BY, McCrindle BW, Dipchand Al: Post-
Scherer SW, Bouffet E, Rutka JT, Pomeroy SL, Lau CC,
transplant lymphoproliferative disorder in pediatric heart
Taylor MD, Gajjar A, Dirks PB, Hawkins CE, Huang A: Frequent
transplant recipients. Journal of Heart and Lung
amplification of a chr19q13.41 microRNA polycistron in
Transplantation 2010: 29: pp 648-657.
aggressive primitive neuroectodermal brain tumors. Cancer
Cell 2009:16: pp 533-546.
Michalski A, Bouffet E, Taylor RE, Hargrave D, Walker D, Picton
S, Robinson K, Pizer B, Bujkiewicz S: The addition of high-dose
Licht C, Pluthero FG, Li L, Christensen H, Habbig S, Hoppe B,
tamoxifen to standard radiotherapy does not improve the
Geary DF, Zipfel PF, Kahr WH: Platelet-associated complement
survival of patients with diffuse intrinsic pontine glioma.
factor H in healthy persons and patients with atypical HUS.
Journal of Neurooncology 2010: March 19 [Epub ahead of print].
Blood 2009: 114: pp 4538-4545.
Morris SK, Dzolganovski B, Beyene J, Sung L: A meta-analysis
Lieberman L, Kirby M, Ozolins L, Mosko J, Friedman J: Initial
of the effect of antibody therapy for the prevention of severe
presentation of unscreened children with Sickle Cell disease:
respiratory syncytial virus infection. BMC Infectious Diseases
The Toronto experience. Pediatric Blood and Cancer 2009: 53:
2009: 9: p 106.
pp 397-400.
Nakahara Y, Northcott PA, Li M, Kongkham P, Yan H, Croul S,
Lusher J, Pipe S, Alexander S, Nugent D: Prophylactic therapy
Ra YS, Eberhart C, Huang A, Bigner D, Grajkowska W,
with Fibrogammin P is associated with a decreased incidence
Van Meter T, Rutka JT, Taylor MD: Genetic and epigenetic
of bleeding episodes: A retrospective study. Haemophilia 2010:
inactivation of Kruppel-like Factor 4 in medulloblastoma.
16: pp 316-321.
Neoplasia 2010: 12: pp 20-27.
Malkin D: Prenatal diagnosis, pre-implantation genetic
Naqvi A, Fadoo Z: Inadvertent intrathecal injection of PEG-
diagnosis and cancer: Was Hamlet wrong? Journal of Clinical
asparaginase. Journal of Pediatric Hematology/Oncology 2010:
Oncology 2009: 27: pp 4446-4447.
32: p 416.
Mallipatna AC, Sutherland JE, Gallie BL, Chan H, H├йon E:
Naqvi A, Fadoo Z, Alvi S: Vaccination guidelines for children
Management and outcome of unilateral retinoblastoma. Journal
with cancer and hematopoietic stem cell transplantation living
of the American Association for Pediatric Ophthalmology and
in resource-poor countries. Pediatric Blood and Cancer 2010:
Strabismus 2009: 13: pp 546-550.
54: pp 3-7.
Maloney AM, Ethier MC, Mitchell D, Zaoutis TE, Sung L:
Nathan PC, Wasilewski-Masker K, Janzen LA: Long-term
Alternaria sinusitis in children with acute myeloid leukemia:
outcomes in survivors of childhood acute lymphoblastic
Case reports from the Childhood Acute Myeloid Leukemia
leukemia. Hematology/Oncology Clinics of North America
Infection Research Group. Leukemia and Lymphoma 2010: 51:
2009: 23: pp 1065-1082.
pp 345-347.
Nicolin G, Parkin P, Mabbott D, Bartels U, Tabori U, Dondey J,
Manlhiot C, Brandao L, Somji Z, Chesney AL, MacDonald C,
Huang A, Rutka J, Buncic JR, Bouffet E: Natural history and
Gurofsky RC, Sabharwal T, Chahal N, McCrindle BW: Long-term
outcome of optic pathway gliomas in children. Paediatric Blood
anticoagulation in Kawasaki Disease: Initial use of low
& Cancer 2009: 15: pp 1231-1237.
molecular weight heparin may maximize potential for coronary
aneurysm regression. Pediatric Cardiology 2010: April 30
[Epub ahead of print].
98
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Odame I: Developing a global agenda for Sickle Cell Disease:
Pope E, Weitzman S, Ngan B, Walsh S, Morel K, Williams J,
Report of an international symposium and workshop in
Stein S, Garzon M, Knobler E, Lieber C, Turchan K, Wargon O,
Cotonou, Republic of Benin. American Journal Preventive
Tsuchiya A: Mycosis fungoides in the pediatric population:
Medicine 2010: 38: pp S571-S575.
Report from an international childhood registry of cutaneous
Oeffinger KC, Nathan PC, Kremer LCM: Challenges after
14: pp 1-6.
lymphoma. Journal Cutaneous Medicine and Surgery 2010:
curative treatment for childhood cancer and long-term follow
up of survivors. Hematology Oncology Clinics of North America
Provan D, Stasi R, Newland AC, Blanchette VS, Bolton-Maggs P,
2010: 24: pp 129-149.
Bussel JB, Chong BH, Cines DB, Gernsheimer TB, Godeau B,
Grainger J, Greer I, Hunt BJ, Imbach PA, Lyons G, McMillan R,
OтАЩGorman CS, Hamilton J, Rachmiel M, Gupta A, Ngan BY,
Rodeghiero F, Sanz MA, Tarantino M, Watson S, Young J,
Daneman D: Thyroid cancer in childhood: A retrospective
Kuter DJ: International consensus report on the investigation
review of childhood course. Thyroid 2010: 20: pp 375-380.
and management of primary immune thrombocytopenia.
Blood 2010: 115: pp 168-186.
Ooi CY, Brand├гo LR, Zolpys L, De Angelis M, Drew W, Jones N,
Ling SC, Fecteay A, Ng VL: Thrombotic events after pediatric
Punnett AS: Malignancy following solid organ and
liver transplantation. Pediatric Transplantation 2010:14:
hematopoietic stem cell transplantation. US Hematology
p 476-482.
2009: 2: pp 49-51.
Ota K, Dimaras H, H├йon E, Gallie BL, Chan HSL: Radiologic
Punnett A, Tsang R, Hodgson D: Hodgkin lymphoma across
surveillance for retinoblastoma metastases unexpectedly
the age spectrum: Epidemiology, therapy, and late effects.
showed disseminated toxocariasis in liver, lung and spinal cord.
Seminars Radiation Oncology 2010: 20: pp 30-44.
Canadian Journal of Ophthalmology 2010: 45: pp 185-186.
Qaddoumi I, Bouffet E: Supplementation of a successful
Pabalan N, Francisco-Pabalan O, Sung L, Jarjanazi H, Oxcelik H:
pediatric neuro-oncology telemedicine-based twinning program
Meta-analysis of two ERCC2 (XPD) polymorphisms, Asp312Asn
by e-mails. Telemedicine Journal E-Health 2009: 15: pp 975-982.
and Lys751Gln, in breast cancer. Breast Cancer Research and
Treatment 2010: April 9 [Epub ahead of print].
Rand M, Revel-Vilk S, Blanchette V, Schmugge M, Clark D,
Pasic I, Shlien A, Durbin A, Stavropoulos DJ, Baskin B,
factor VIII for continuous infusion use in haemophilia A.
Novokmet A, Malkin D: Recurrent focal copy-number changes
Haemophilia 2010: 16: pp 72-79.
Lillicrap D: In vitro and in vivo stability of diluted recombinant
and loss-of-heterozygosity implicate three genes at
chromosome 3q13.31 in osteosarcoma. Cancer Research
Ristovski-Slijepcevic S, Barr R, Bernstein M, Nathan PC:
2010: 70: pp 160-171.
A cross-Canada survey of clinical programs for the care
of survivors of cancer in childhood and adolescence.
Phipps S, Barrera M, Vannatta K, Xiong X, Doyle JJ, Alderfer MA:
Paediatrics & Child Health 2009: 14: pp 375-378.
Complementary therapies for children undergoing stem cell
transplantation: report of a multisite trial. Cancer 2010: 116:
Roberts AM, Watson IR, Foster D, Irwin MS, Ohh M:
pp 3924-3933.
Suppression of HIF-2alpha restores p53-dependent
chemosensitivity in renal cell carcinoma. Cancer
Research 2009: 69: pp 9056-9064.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 99
Rogovik AL, Li Y, Kirby MA, Friedman JN, Goldman RD:
Schechter T, Ishaqi KM, Rojas M, Irina Z, Doyle JJ, Gassas A:
Admission and length of stay due to painful vaso-occlusive
Outcome of hematopoietic stem cell transplantation of children
crisis in children. American Journal of Emergency Medicine
with very high risk acute lymphoblastic leukemia in first
2009: 27: pp 797-801.
complete remission. Pediatric Transplantation 2010: 14:
pp 377-382.
Rogovik AL, Persaud J, Friedman JN, Kirby M, Goldman RD:
Paediatric vaso-occlusive crisis and weather conditions-under
Schechter T, Liebman M, Gassas A, Ngan B, Navarro O: BK
review at Paediatric Care. American Journal of Emergency
virus associated hemorrhagic cystitis presenting as mural
Medicine 2009: 27: pp 797-801.
nodules in the urinary bladder after hematopoietic stem cell
transplantation. Pediatric Radiology 2010: 40: pp 1430-1433.
Ronghe M, Hargrave D, Bartels U, Tabori U, Vaidya S,
Chandler C, Kulkarni A, Bouffet E: Vincristine and carboplatin
Schechter T, Macartney C, Finkelstein Y, Gassas A,
chemotherapy for unresectable and/or recurrent low grade
Husain M, Doyle J, Dupuis LL: Dismal response to high-dose
glioma of the brainstem. Pediatric Blood and Cancer 2010: 55:
methylprednisolone after failure to respond to standard dose
pp 471-477.
in patients with acute GVHD. Bone Marrow Transplant 2010:
March 8 [Epub ahead of print].
Rosenberg PS, Zeidler C, Bolyard AA, Alter BP, Bonilla MA,
Boxer LA, Dror Y, Kinsey S, Link DC, Newburger PE,
Scheinemann K, Bartels U, Huang A, Hawkins C, Kulkarni AV,
Shimamura A, Welte K, Dale DC: Stable long-term risk of
Bouffet E, Tabori U: Survival and functional outcome of
leukemia in patients with severe congenital neutropenia
childhood spinal cord low grade gliomas. Journal of
maintained on G-CSF therapy. British Journal of Haematology
Neurosurgery 2009: 4: pp 254-261.
2010: 150: pp 196-199.
Schulte F, Bartels U, Bouffet E, Hamilton J, Barrera M: Body
Rujkijyanont P, Adams S, Beyene J, Dror Y: Bone marrow cells
weight, social competence, and cognitive functioning in
from patients with Shwachman-Diamond Syndrome abnormally
survivors of childhood brain tumors. Pediatric Blood Cancer
express genes involved in ribosome biogenesis and RNA
2010: 55: pp 532-539.
processing. British Journal of Haematology 2009: 145:
pp 806-815.
Schwertz H, K├╢ster S, Kahr WH, Michetti N, Kraemer BF,
Ryan C, Price V, John P, Mahant S, Baruchel S, Brandao L,
Zimmerman GA, Weyrich AS: Anucleate platelets
Blanchette V, Pope E, Weinstein M: Kasabach-Merritt
generate progeny. Blood 2010: 115: pp 3801-3809.
Weitz DA, Blaylock RC, Kraiss LW, Greinacher A,
phenomenon: A single centre experience. European Journal
of Haematology 2010: 84: pp 97-104.
Somers G, Ho M, Pienkowska M, Shlien A, Malkin D,
Ackerley C, Zielenska M: IGF2 is highly expressed in pediatric
Sakaguchi S, Garcia-Bournissen F, Kim R, Shwarz UI,
undifferentiated sarcomas and reveals two distinct cytoplasmic
Nathan PC, Ito S: Prolonged neutropenia after irinotecan-based
trafficking patterns. Pediatric Developmental Pathology
chemotherapy in a child with polymorphisms of UGT1A1
2010:13: pp 169-177.
and SLCO1B1. Archives of Disease in Childhood 2009: 94:
pp 981-982.
Soylu H, Brand├гo LR, Lee KS: Efficacy of local instillation
of recombinant tissue plasminogen activator for restoring
occluded central venous catheters in neonates. Pediatrics
2010: 156: pp 197-201.
100
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Sung L: Invasive fungal infections in children with cancer:
Valentino LA, Carcao M, Mathew P, Leissinger CA, Berntorp E,
Challenges to optimal management. Journal of Pediatrics
Blanchette V, DiMichele DM, Escuriola-Ettingshausen C,
2010: 156: pp S78-S86.
Ewenstein B, Ewing N, Gringeri A, Hoots WK, Negrier C: The
application of bypassing-agent prophylaxis in hemophilia A
Sung L, Yanofsky R, Klaassen RJ, Dix D, Pritchard S, Winick N,
patients with inhibitors: A meeting report. Haemophilila 2009:
Alexander S, Klassen A: Quality of life during active treatment
15: pp 959-965.
for pediatric acute lymphoblastic leukemia. International
Journal of Cancer 2010: June 22 [Epub ahead of print].
Vogiatzi MG, Macklin EA, Trachtenberg FL, Fung EB,
Cheung AM, Vichinski E, Olivieri N, Kirby M, Kwiatkowski JL,
Tabori U, Baskin B, Shago M, Alon N, Taylor MD, Ray PN,
Cunningham M, Holm I, Fleisher M, Grady RW, Peterson C,
Bouffet E, Malkin D, Hawkins C: Universal poor survival
Giardina PJ: Differences in the prevalence of growth, endocrine
in children with medulloblastoma harboring somatic
and Vitamin D abnormalities among the various thalassemia
TP53 mutations. Journal of Clinical Oncology 2010:
syndromes in North America for the Thalassemia Clinical
28: pp 1345-1350.
Research Network. British Journal Haematology 2009: 146:
pp 546-556.
Tabori U, Shilen A, Baskin B, Levitt S, Ray P, Alon N, Hawkins C,
Bouffet E, Pienkowska M, Lafay-Cousin L, Gozali A, Zhukov N,
Watanabe K, Ambekar C, Wang W, Ciccolini A, Schimmer A,
Shane L, Gonzalez I, Finlay J, Malkin D: TP53 alterations
Dror Y: SBDS-deficiency results in specific hypersensitivity
determine clinical subgroups and survival of patients with
to Fas stimulation and accumulation of Fas at the plasma
choroid plexus tumors. Journal of Clinical Oncology 2010:
membrane. Apoptosis 2009: 14: pp 7-89.
28: pp 1995-2001.
Watson IR, Li BK, Blanch A, Roche O, Ohh M, Irwin MS:
Teuffel O, Ethier MC, Beyene J, Sung L: Association between
Chemotherapy induces NEDP1-mediated destabilization
tumor necrosis factor-alpha promoter -308 A/G polymorphism
of MDM2. Oncogene 2010: 29: pp 297-304.
and susceptibility to sepsis and sepsis mortality: A systematic
review and meta-analysis. Critical Care Medicine 2010: 38:
Weitzman S, Arceci R, Braier J, Donadieu J, Egeler RM, Grois N,
pp 276-282.
Ladisch S, Webb D, Whitlock J: 2тАЩ-Chlorodeoxyadenosine
(2-CdA) as salvage therapy for Langerhans Cell Histiocytosis
Tomlinson D, Gibson F, Treister N, Baggott C, Judd P,
(LCH): Results of the LCH-S-98 protocol of the Histiocyte
Hendershot E, Maloney AM, Doyle J, Feldman B, Kwong K,
Society. Pediatric Blood & Cancer 2009: 53: pp 1271-1276.
Sung L: Refinement of the ChildrenтАЩs International Mucositis
Evaluation Scale (ChIMES): Child and parent perspectives
Wolter J, Angelini P, Irwin MS: P53 Family: Novel therapeutic
on understandability, content validity and acceptability.
targets in neuroblastoma. Future Oncology 2010: 6:
European Journal of Oncology Nursing 2010: 14: pp 29-41.
pp 429-444.
Tomlinson D, Gibson F, Treister N, Baggott C, Judd P,
Wong VC, Morrison A, Tabori U, Hawkins CE, Hawkins:
Hendershot E, Maloney AM, Doyle J, Feldman B, Kwong K,
Telomerase inhibition as a novel therapy for pediatric
Sung L: Understandability, content validity, and overall
ependymoma. Brain Pathology 2010: 20: pp 780-786.
acceptability of the ChildrenтАЩs International Mucositis
Evaluation Scale (ChIMES): Child and parent reporting. Journal
of Pediatric Hematology/Oncology 2009: 31: pp 416-423.
Yang JY, Williams S, Brandao L, Chan AKC: Neonatal and
childhood right atrial thrombosis: Recognition and a riskstratified treatment approach. Blood Coagulation and
Fibrinolysis 2010: 21: pp 301-307.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 101
Zarghooni M, Bartels U, Lee E, Buczkowicz P, Morrison A,
Breaky V, Truong T, Punnett A: Chemotherapy In: Handbook
Huang A, Bouffet E, Hawkins C: Whole-genome profiling of
of Supportive Care In Paediatric Oncology (Abla O, ed.).
pediatric diffuse intrinsic pontine gliomas highlights platelet-
Jones and Bartlett Publishers, Sudbury, MA, 2009.
derived growth factor receptor {alpha} and poly (ADP-ribose)
polymerase as potential therapeutic targets. Journal of Clinical
Cada M, Lau W, Carcao M: Haematologic complications. In:
Oncology 2010: 28: pp 1337-1344.
SickKids Handbook of Supportive Care in Pediatric Oncology.
(Abla O, ed.). Jones and Bartlett Publishers, Sudbury, MA, 2009.
Zwaan CM, Reinhardt D, Hitzler J, Vyas P: Acute leukemias
in children with Down syndrome. Hematology Oncology
Carcao M, Blanchette V: Workup of a bleeding child. In:
Clinics of North America 2010: 24: pp 19-34.
Hemophilia (Lee C, Berntorp E, Hoots K, eds.). Wiley-Blackwell,
New Jersey, 2010.
Books and Book Chapters
Abla O: Guidelines for drug usage in paediatric oncology. In:
Carcao M: Mild hemophilia. In: All about Hemophilia A:
The Hospital for Sick Children Handbook of Supportive Care in
A Guide for Families, 2nd Edition. Canadian Hemophilia
Pediatric Oncology. (Abla O, ed.). Jones and Bartlett Publishers,
Society, Toronto, 2010.
Sudbury, MA, 2009.
Cox K, Price V, Kahr WHA: Inherited platelet disorders: A
Abla O, Dupuis L, Chong D, Ling S: Gastrointestinal
clinical approach to diagnosis and management. In: Expert
complications. In: The Hospital for Sick Children Handbook
Review of Hematology. Expert Reviews Ltd., London, 2010.
of Supportive Care in Pediatric Oncology. (Abla O, ed.).
Jones and Bartlett Publishers, Sudbury, MA, 2009.
Das B, Tsuchida R, Baruchel S, Malkin D, Yeger H: The idea
and evidence for the tumor stemness switch. In: Regulatory
Abla O, Naqvi A: Acute allergic reactions. In: The Hospital
Networks in Stem Cells (Rajasekhar VK, Vemuri MC, eds.).
for Sick Children Handbook of Supportive Care in Pediatric
Humana Press, New York, 2009.
Oncology. (Abla O, ed.). Jones and Bartlett Publishers,
Sudbury, MA, 2009.
De Souza C, Abla O: Psychiatric issues. In: The Hospital
for Sick Children Handbook of Supportive Care in Pediatric
Abla O, Shenkier T, Jhanke K: Rare variants of primary CNS
Oncology. (Abla O, ed.). Jones and Bartlett Publishers,
lymphoma: Pediatric primary CNS lymphoma. In: Lymphoma
Sudbury, MA, 2009.
and Leukemia of the Nervous System. (Batchelor T,
DeAngelis L, eds.). Springer, Heidelberg, 2010.
Green G, Punnett A: Nutrition. In: Handbook of Supportive
Care in Paediatric Oncology (Abla O, ed.). Jones and Bartlett
Abla O, Weitzman S: ATRA (Retinoic Acid) Syndrome. In: The
Publishers, Sudbury, MA, 2009.
Hospital for Sick Children Handbook of Supportive care in
Pediatric Oncology. (Abla O, ed.). Jones and Bartlett Publishers,
Sudbury, MA, 2009.
Hopyan S, Gupta A: What is the best treatment of malignant
bone tumors in children? In: Evidence-Based Orthopaedics
(Wright JG, ed.). Saunders-Elsevier, Philadelphia, 2009.
Brandao L, Williams S, Breakey V, Abla O: Thrombotic
Emergencies. In: The Hospital for Sick Children Supportive
Odame I: Hematology considerations for the PICU. In: Manual
Care in Paediatric Oncology. (Abla O, ed.). Jones and
of Pediatric Intensive Care (Kirpalani H, Huang L, Duffet M,
Bartlett Publishers, Sudbury, MA, 2009.
Michenko M, eds.). BC Decker, Hamilton, 2009.
102
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Odame I, Chan AK: Coagulation disorders. In: Manual of
A multi-centre, open-label, single-arm, and multiple dosing trial
Pediatric Intensive Care (Kirpalani H, Huang L, Duffet M,
on efficacy and safety of monthly recombinant factor XIII (rFXIII)
Michenko M, eds.). BC Decker, Hamilton, 2009.
in subjects with congenital factor XIII deficiency - safety
extension trial. Carcao M, Blanchette V. Novo Nordisk
Punnett A: Mucositis. In: Handbook of Supportive Care
($12,647.60/patient 2010-present)
in Paediatric Oncology (Abla O, ed.). Jones and Bartlett
Publishers, Sudbury, MA, 2009.
A multicentre, randomized, open-label phase II trial evaluating
deferasirox compared with deferoxamine in patients with
Punnett A, Abla O: Hyperleukocytosis. In: Handbook of
cardiac iron overload due to chronic blood transfusions.
Supportive Care in Paediatric Oncology (Abla O, ed.).
Maseruka H, Jehl V, Lawniczek R, Odame I. Novartis
Jones and Bartlett Publishers, Sudbury, MA, 2009.
($12,343/patient 2009-2011)
Punnett A, Taylor T: Menses suppression. In: Handbook
A novel classification for childhood low grade gliomas. Hawkins
of Supportive Care in Paediatric Oncology (Abla O, ed.).
C, Bouffet E, Scheinemann K, Jabado N, Tabori U. BrainChild
Jones and Bartlett Publishers, Sudbury, MA, 2009.
Foundation ($60,000 2009-2011)
Robertson JD, Blanchette VS, Kahr WHA: Quantitative platelet
A phase I study of vinblastine in combination with rapamycin
disorders. In: Practical Haemostasis and Thrombosis,
in pediatric patients with recurrent or refractory solid tumors
2nd Edition. Wiley-Blackwell Publishing, Oxford, 2009.
including CNS tumors. Baruchel S. Solving Kids Cancer NYC,
James Birrell Fund ($121,690 2009-2010)
Segbefia C, Odame I: Childhood leukemia. In: Synopsis
of Hematology (Okpala I, Johnson C, eds.). Createspace
A Phase I/II study of CP751,851 and IGF IR antibody in
Publishers, Charleston, 2010.
refractory/recurrent solid tumors. Baruchel S. Pfizer
($22,349/patient 2008-2010)
Weitzman S, Egeler RM: Histiocytic disorders. In: Cancer
in Children and Adolescents (Carroll WL, Finlay JL, eds.).
A Phase I/II study of Temsirolimus in refractory/recurrent solid
Jones and Bartlett Publishers, Sudbury, MA, 2009.
tumors. Baruchel S. Wyeth CSA ($31,800/patient 2008-2010)
Funding
A phase II study of vinblastine in chemotherapy naive children
A 5-year observational study (registry) of children aged 2 to < 6
with progressive low grade gliomas. Bouffet E, Tabori U,
years at enrollment with transfusional hemosiderosis treated
Hawkins C, Keene D. Ontario Institute of Cancer Research
with deferasirox. Araosmigh-Bensafson C, Lawniczek T,
($430,197 2007-2010)
Hmissi A, Odame I. Novartis ($2,400/patient 2008-2012)
A pilot prospective study of measurement of ovarian function
A group wide phase II study of ET-743 in recurrent pediatric
in adolescent females receiving cancer therapy. Gupta A,
sarcoma. Baruchel S. ChildrenтАЩs Oncology Group ($75,000
Lee-Chong A, Allen L, Traubici J, Kives S. Comprehensive
2007-2010)
Cancer Center Adolescent Transition Care Program
Competition ($50,000 2009-2010)
A multi-centre, open-label, single-arm, and multiple dosing trial
on efficacy and safety of monthly recombinant factor XIII (rFXIII)
A prospective non-interventional study to describe health-
in subjects with congenital factor XIII deficiency. Carcao M,
related quality of life of youth and young adults with moderate
Blanchette V. Novo Nordisk ($16,356/pt 2009-2010)
or severe hemophilia A using recombinant factor VIII (Helixate
FS). St. Louis J, Young N, Blanchette V. CSL Behring
($296,388 2009-2013)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 103
A prospective study of the multidimensional quality of life in
Atypical hemolytic uremic syndrome: A new pathological role for
pediatric HSCT recipients. Schechter T, Doyle J, Gassas A.
complement and coagulation control in platelets. Licht CPB,
Canadian Institutes of Health Research ($5,000 2009-2010)
Kahr WHA. Heart and Stroke Foundation of Canada ($123,510
2009-2011)
A randomized controlled multicenter non-inferiority trial of twice
daily low dose dexamethasone versus high dose dexamethasone
Biochemical and genetic analyses of JPO2, a novel of c-Myc
for symptom control in children undergoing cranial or
oncogene interacting protein. Huang A. National Cancer
craniospinal radiation after complete or near complete
Institute of Canada ($440,082 2006-2010)
resection of a brain tumour. Bartels U. C17 Research
Network ($120,000 2009-2011)
Canadian family physicians attitudes and knowledge regarding
the care of adult survivors of childhood cancer: a survey study.
A three-month prospective open label study of therapy with
Nathan PC, Henderson T, Daugherty C, Del Giudice L, Grunfeld
Fragmin┬о (Dalteparin Sodium Injection) in children with
E. Pediatric Oncology Group of Ontario Seed Funding Grant
malignancies and venous thromboembolism. Brand├гo LR,
($14,000 2010-2011)
Williams S. Eisai Inc. ($8,000/patient 2010-2014)
Characterization of JPO2, a novel c-Myc co-transforming protein.
Advanced body-machine interfaces for voiceless
Rodrigues T and Huang A. Canadian Institute of Health
communications. Chau T, Bouffet E, Panacis Medical.
Research Doctoral Research Awards ($63,000 2007-2010)
Ontario Centres of Excellence ($240,000 2008-2011)
Characterization of novel oncogenic loci in childhood primitive
An international Phase II trial investigating nimotuzumab in
neuroectodermal brain tumors. Huang A. Canadian Institute of
pediatric patients with recurrent diffuse pontine glioma (DIPG).
Health Research ($450,000 2009-2013)
Bouffet E, Baruchel S. YM Bioscience ($12,000/pt 2007-2010)
Characterizing ALL stem cells. Guidos C, Danska J, Hitzler J.
An interprofessional team orientation experience. Mehta A,
Ontario Institute of Cancer Research ($630,000 2008-2012)
Honeyford L, Punnett A. C17 Education Grant Competition
($1,910 2009-2010)
Child Health Research Institute [Infrastructure for new
Research Building]. Rossant J, Malkin D, + 24 other co-
Antithrombin enhancement may improve anticoagulation
applicants. Canada Foundation for Innovation ($91,000,000
efficiency in infants undergoing cardiopulmonary bypass
2008-2013)
for cardiac surgery. Gruenwald C, Chan A, Van Arsdell GS,
McCrindle BW, Holtby H, Brand├гo LB, Manlhiot C. Heart and
Childhood Cancer Survivor Study (CCSS) expansion. Robison L,
Stroke Foundation of Ontario/Baxter Healthcare Corporation
Nathan P. National Institutes of Health/National Cancer
($395,518 2010-2012)
Institute ($27,365,542 2005-2010)
Assessment of pain survey. Foote D, Odame I, Thalassemia
ChIMES - Understandability and content validity. Sung, L,
Clinical Research Network. National Heart, Lung & Blood
Tomlinson, D. Pediatric Oncology Group of Ontario ($14,992
Institute ($674.00/patient 2009-2010)
2009-2010)
104
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Clonality of T-cells in peripheral blood of children with
Delivery of rFVIII via direct incorporation into platelets.
cutaneous lymphomas: An open label co-hort pilot study.
Kahr WHA. Bayer Canada ($230,000 2009-2011)
Pope E, Weitzman S, Chakkittakandiyil A, Zeller J, Alexander S,
Abdelhaleem M, Ngan B. Ride to Conquer Cancer, Division
of Hematology/Oncology ($25,000 2010-2011)
Detection of uptake of rFVIII (BAY 79-4979 & rFVIII-FS) by
platelets via IF and immunoblotting and monitoring the effects
of platelet-rFVIII via hemostatic assays. Kahr WHA. Bayer
Collaborative Academic Rehabilitation Engineering (CARE).
HealthCare ($24,662 2009-2011)
Chau T, Macarthur C, Fehlings D, Biddiss E, Andrysek J, Wright V,
Sejdic E, Mckeever P, Zabjek K, Bouffet E, Ducharme M,
Determination of the extent and role of monoallelic gene
Hisham A. Natural Sciences and Engineering Research
expression in low and high grade pediatric brain tumors.
Council, Collaborative Research and Training Experience
Tabori U. Comprehensive Cancer Centre, The Hospital for Sick
(CREATE) Program ($1,650,000, 2009-2015)
Children ($50,000 2009)
Combined telomerase inhibition and drug screen as novel
Developing an on-line self-management and transitional care
therapies for tumor initiating cells in pediatric nervous system
program for adolescents with cancer. Stinson J, Gupta A, Sung
tumors. Tabori U. Canadian Institutes of Health Research
L, Dettmer E. Comprehensive Cancer Center, The Hospital for
($300,000 2010-2014)
Sick Children ($43,750 2009-2010)
Combined telomerase inhibition and drug screen as novel
Development and testing of a multidimensional electronic pain
therapies for tumor initiating cells in pediatric nervous system
diary for youths with cancer. Stinson J, Nathan PC, Maloney AM,
tumors. Tabori U. Ontario Institute of Cancer Research
Gerstle T, Alman B, Hopyan S, Yanofsky R, Portwine C,
($526,152, 2009-2011)
Johnston D, Strahlendorf C. C17 Research Network ($199,929
2010-2012)
Core neuro-cognitive functions in children treated for posterior
fossa tumors. Mabbott DJ, Bouffet E, Noseworthy M, Laughlin
Development of efficacy parameters for the maintenance
S, Kulkarni A, Laperriere N, Sharpe M, Keene D, Montour-Proulx
phase of Acute Lymphoblastic Leukemia (ALL) treatment.
I, Briere M, Strother D, Witon A, Wilson B, Chafe S, McConnell
Hitzler J, Lee-Chong A, Lieberman M, Zagorski B, Nathan PC.
D, Hukin J, Fryer C. National Cancer Institute of Canada
Comprehensive Cancer Centre, The Hospital for Sick Children
($750,000 2007-2012)
($7,000 2010-2011)
Cultural adaptation, evaluation of psychometric properties of
DIPG Think Tank Meeting. Bartels U. Brainchild Foundation
the Psychosocial Assessment Tool (PAT2.0) and feasibility of
($25,000 2010-2011)
its use with families and children newly diagnosed with cancer
in Ontario. Barrera M, Punnett A, Cataudella D, Beaton D,
Discovery and characterization of C19MC a novel oncogenic
Zelcer S, Cassano J, Portwine C, Cassidy M, Johnston D,
miRNA locus in malignant brain tumors. Huang A. Canadian
Jensen P, Silva M, Atenafu E, Greenberg C, Bartels U, Nathan
Institutes of Health Research ($520,000 2010-2014)
PC. Pediatric Oncology Group of Ontario ($50,000 2010)
DNA Copy Number Variation in Li-Fraumeni Syndrome. Malkin D.
Defining the clinical phenotype of inherited marrow failure
Canadian Institutes for Health Research ($784,000 2009-2013)
syndromes and the risk factors for severe hematological
complications and cancer by the Canadian Marrow Failure
Early Researcher Award. Nathan PC. Ministry of Research and
Registry (CIMFR). Dror Y. C17 Research Network ($120,300
Innovation ($100,000 2010-2013)
2009-2011)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 105
Establishment of a comprehensive genetic bank for children
Genetic determinants of predisposition to childhood brain
with brain tumors. Tabori U, Malkin D. Brainchild Foundation
tumor initiation and progression. Tabori U, Malkin D.
($42,600 2008-2010)
Brainchild Foundation ($60,000 2008-2010)
Examining the relationship between white matter integrity and
Genetic epidemiology of osteosarcoma. Spector L, Malkin D,
the speed of neural processing in healthy children and children
Ross, J, Sklar C, Nagarajan R. National Institutes of Health
with brain tumours. Mabbott DJ, Dockstader C, Tabori U,
($1,000,000 2006-2011)
Bouffet E. Comprehensive Cancer Centre, The Hospital for
Sick Children (49,971 2010-2011)
Genetic predictors of acute myeloid leukemia treatment
response. Alpenc R, Sung L, Zaoutis T, Chen J, Alonzo T,
Exploring the barriers to successful transition to adult care
Lehrnbecher T. National Cancer Institute ($125,000
among childhood cancer survivors. Nathan PC, Klassen A,
2010-2014)
Barr R, Boydell K, Dettmer E, DтАЩAgostino N, Greenberg M.
Canadian Institutes of Health Research ($93,372 2010-2011)
Genetic predisposition for bone marrow failure. Dror Y.
Donor-directed funds ($20,000 2008-2010)
FDG-PET/CT in the evaluation of post-transplant
lymphoproliferative disorder in children following solid organ
Genome-wide analysis of bone marrow failure-related genetic
transplantation. Shammas A, Charron M, Punnett A, Hong T.
alterations in inherited marrow failure syndromes. Dror Y,
Comprehensive Cancer Centre, The Hospital for Sick Children
Beyene J, Shago M. Canadian Institutes of Health Research
($50,000 2010-2011)
($357,000 2010-2013)
Feasibility and effectiveness of the use of the psychosocial
Genome-wide profiling of pediatric diffuse intrinsic pontine
assessment tool (PAT 2.0) with families and children newly
glioma. Hawkins C, Bartels U, Stavropoulos J, Bouffet E.
diagnosed with cancer in Ontario. Barrera M, Punnett A,
National Brain Tumor Society ($198,670 2009-2011)
Cataudella D, Zelcer S, Cassano J, Portwine C, Cassidy M,
Johnston D, Jensen P, Silva M, Atenafu E, Greenberg C.
Identification of educational and infrastructural barriers to
Pediatric Oncology Group of Ontario ($50,000 2009-2010)
prompt antibiotic administration of children with cancer with
fever and neutropenia. Gupta S, Punnett A. C17 Education
Functional Oncogenomics for the Discovery of Cancer Drivers
Grant Competition ($2,400 2009-2010)
and Unique Subclasses (FOCUS). Khokha R, Irwin MS. Ontario
Research Fund (4,364,360 2010-2013)
Improving transition to follow-up care in childhood cancer
survivors: development of a questionnaire to measure
Genetic alterations converge on cell adhesion pathways in
transition readiness. Barr R, Klassen A, Nathan PC, Greenberg
childhood sPNET. Huang A. Brain Tumor Society ($200,000
M, Boydell K, DтАЩAgostino N, Dettmer E. Hamilton Academic
2008-2010)
Health Sciences Organization ($133,701 2009-2012)
Genetic characterization of CNS rhabdoid tumors. Huang A,
Infrastructure Grant Pediatric Consortium. Blanchette VS,
Bouffet E, Hawkins C. The Hospital for Sick Children
Devine S, Weitzman S, Portwine C, Halton J, Jardine L, Silva M.
Foundation ($70, 000 2009-2011).
Ontario Cancer Research Network ($990,404 2006-2011)
106
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Integrative genomics for health research тАУ Phase II. Scherer S,
Patterns and predictors of health care utilization by adult
Malkin D +8 other co-PIs. Canada Foundation for Innovation
survivors of childhood cancer: A Pediatric Oncology Group of
($19,989,710 2009-2013)
Ontario and Institute for Clinical Evaluative Sciences population
database linkage study. Nathan PC, Greenberg M, Hodgson D,
International rare histiocytic disorders registry. Abla, O.
Pole J, Agha M, Guttmann A, Sutradahr R. Canadian Institutes
Histiocytosis Association of America/Histiocytosis
of Health Research ($427,052 2009-2012)
Association of Canada (23,000 2009-2010)
Perceived cognitive function item bank for children who
Modulation of p73 by cyclo-oxygenase inhibitors in
undergo cancer treatment. Lai JS, Tucker K, Bouffet E, Turner C,
neuroblastoma. Irwin MS. National Cancer Institute of
Goldman S, Mabbott D. National Institutes of Health
Canada/Canadian Cancer Society ($373,829 2008-2011)
($1,033,053 2008-2010)
Molecular and pharmacologic correlates of acute myeloid
Pharmacokinetics and pharmacodynamics of thymoglobulin
leukemia in Down syndrome. Taub J, Campana D, Hitzler J,
in paediatric hematopoietic stem-cell transplant. Schechter-
Lacayo N. National Institutes of Health ($2,189,783
Finkelstein T, Gassas A, Dupuis L, Doyle JJ, Pollock S,
2007-2011)
Finkelstein Y. Comprehensive Cancer Centre, The Hospital
for Sick Children ($31,660 2009-2010)
Molecular determinants of Li-Fraumeni Syndrome-associated
cancers. Malkin D. Canadian Institutes for Health Research
($750,150 2010-2015)
Phase II study of high dose chemotherapy with cyclosporin
for vision-threatening intraocular retinoblastoma. Chan HSL,
Gallie BL. Terry Fox Research Institute ($151,816 2010-2012)
Molecular determinants of tumor formation in Li-Fraumeni
Syndrome. Malkin D. National Cancer Institute of Canada
Physical activity to modify sequelae and QOL in childhood ALL:
($423,000 2007-2010)
a nursing trial. Cox C, Nathan PC, Bhatia S, Wasilewski K,
Welk G, Ness K, Srivastava DK, Robison L, Howard S, Kaste S.
Molecular targeted therapies of childhood choroid plexus
National Institutes of Health/ National Cancer Institute
carcinoma. Gilbertson R, Malkin D, Guy K, Ellison D.
($4,544,841 2009-2014)
US Department of Defense ($1,750,000 2010-2013)
Post-marketing observational study on children treated with
National study of prophylaxis in adolescents and young
Exjade. Kirby-Allen M, Odame I. Novartis ($20,000 2008- 2011)
adults with inherited severe bleeding disorders. Carcao MD,
Blanchette VB, Chan A, Teitel J, Lillicrap D, Wu J. Bayer/
Predicting late effects of individual cancer survivors: a pilot
Canadian Blood Services/Hema-Quebec Partnership Fund
methodological study. Yasui Y, Greenberg M, McBride M,
($165,899 2007-2010)
Nathan PC. Canadian Institutes of Health Research ($58,570
2010-2011)
Nilotinib in growing vestibular schwannomas. Guha A, Eldestein
K, Laperriere N, Rutka J, Bouffet E, Zadeh G. Ontario Institute
Predicting late effects of individual cancer survivors. Yasui Y,
for Cancer Research ($538,142.67 2010-2012)
Greenberg M, Mcbride M, Nathan PC. Canadian Institutes of
Health Research ($109,049 2010-2012)
p73 modulatory proteins: Roles in apoptosis and
chemosensitivity. Irwin MS. National Cancer Institute of
Predicting the risk of infection in children receiving
Canada/Canadian Cancer Society Research Institute
chemotherapy for acute myeloid leukemia. Sung L. Canadian
($427,500, 2010-2013)
Institutes of Health Research ($300,000 2009-2014)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 107
Prediction of tumor resistance and normal brain sensitivity
Role of p73 in neuroblastoma and sensitivity to therapy. Irwin
to cranial irradiation in pediatric brain tumors. Tabori U.
MS. Elsie Winifred Crann Memorial Trust Award for Research
Brainchild Foundation ($50,000 2009-2011)
in Life Sciences, University of Toronto ($35,000 2008-2010)
Predictors of functional and neuro-cognitive outcomes in
Role of SATB2-p63 Interaction in HNSCC and chemosensitivity.
long term survivors of pediatric low grade gliomas. Tabori U,
Irwin MS. Cancer Research Society ($120,000 2008-2010)
Mabbott DJ, Rubin J, Gutmann D, Bouffet E. Pediatric
Brain Tumour Foundation of the United States ($100,000
2008-2010)
Serum biomarkers as predictors of bronchiolitis obliterans
in children receiving allogeneic hematopoietic stem cell
transplantation: A pilot study. Gassas A, Sung Lillian, Doyle JJ,
Prevalence and characterization of post-thrombotic syndrome
Finkelstein-Schechter T, Dell S, Subbarao P, Palaniyar N.
after pediatric cardiac surgery. McCrindle BW, Manlhiot C,
Comprehensive Cancer Centre, The Hospital for Sick Children
Brand├гo L, Williams S, Chan AK, Gruenwald CE, Menjak IB.
($50,121 2009-2010)
Labatt Family Heart Centre ($39,560 2009-2010)
Severe iron-deficiency anemia in infants and young children:
Prognostic and therapeutic implications for telomere
Canadian Pediatric Surveillance Program. Zlotkin S, Parkin P,
maintenance and telomerase inhibition in pediatric high grade
McCourt C, Wong S, Grabowski J, Carcao M, Belletrutti M.
gliomas. Tabori U. Canadian Institutes of Health Research
Canadian Paediatric Society/ Public Health Agency of
($385,811 2008-2011)
Canada (In-kind 2009-2011)
Quantitative non-invasive MRI measurements of
Silent Infarct Transfusion (SIT) trial in patients with Sickle Cell
cerebrovascular reactivity in children with sickle cell disease.
Disease. Debaum M, Odame I. National Heart, Lung and Blood
Kassner A, Williams S, Shroff M, deVeber G. Canadian
Institute ($13,000/patient 2009-2010)
Institutes of Health Research ($94,000 2010-2011)
Studies of alpha granule formation in human megakaryocytes
Randomized study of first TIME Immunotolerance Induction in
and platelets. Kahr WHA. Canadian Institutes of Health
patients with severe type A haemophilia with inhibitor at high
Research Canada ($689,721 2010-2015)
risk of failure: comparison of induction of immune tolerance
with FVIII concentrates with or without Von Willebrand factor.
TCD with transfusions changing to hydroxyurea (TWiTCH).
Carcao M. City of Hope Medical Centre (тВм1000/pt. 2009-present)
Williams S, Odame I. National Heart, Lung, and Blood
Institute ($23 million 2009-2014)
Relative bioavailability of an extemporaneous oral suspension
of aprepitant in adolescents. Dupuis L, Nathan PC, Hendershot
Team grant in physical activity, mobility and health (letter
E, Walsh K, Walker S, Zupanec S. Comprehensive Cancer
of intent): exercise in chronically ill children. Feldman B,
Centre, The Hospital for Sick Children ($45,692 2010-2011)
Noseworthy M, Tein I, Wells G, Biggar W, Coates A, Faulkner G,
Rodin: Research Of determinants of inhibitor development
Stephens S, Tarnopolsky M, Timmons B, Tse S, Vajsar J.
among previously untreated patients with haemophilia.
Canadian Institutes of Health Research ($10,000 2009-2010)
Hamilton R, McCrindle B, Nathan PC, Ratjen F, Schneiderman J,
Carcao M, Blanchette V. University Medical Center Utrecht
(тВм250/patient 2007-present)
108
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Teens taking charge: Developing an online self-management
The Von Willebrand Disease (VWD) international prophylaxis
and transitional care program for adolescents with cancer.
(VIP) study. Carcao M. Rho Inc. ($2,500 US/patient
Stinson J, Sung L, Gupta A, Dettmer E. Comprehensive Cancer
2009-present)
Centre, The Hospital for Sick Children ($50,000 2009-2010)
To improve infrastructure for paediatric cancer clinical trials.
Thalassemia clinical research network registry. Kirby M.
Pappo A, Malkin D, Devine S, Hitzler H, Silva M, Barr R,
National Institutes of Health ($45,696 2005-2010)
Halton J, Jardine L, Baruchel S, Bouffet E. Ontario Cancer
Research Network ($990,404 2005-2010)
Thalassemia longitudinal cohort study. Neufeld E, Odame I,
Thalassemia Clinical Research Network. National Heart,
Training program in protein folding and interaction dynamics:
Lung and Blood Institute ($1800/patient 2005-2010)
principles and diseases. Houry WA, Forman-Kay JD, Adeli K,
The genetic basis of severe sickle cell disease: The never lost
Glover JR, Gradinaru C, Heon E, Kahr WH, Kay LE, Lingwood CA,
international cohort study. Kirby M. ChildrenтАЩs Discovery
Mahuran DJ, Mcgavin MJ, Robertson J, Schmitt-Ulms G, Steipe B,
Institute ($149,968 2008-2012)
Williams DB, Wodak S, Woolley AG, Zhao R. Canadian
Chakrabartty A, Chalikian TV, Chan HS, Davidson AR, Fraser PE,
Institutes of Health Research ($1,950,000 2009-2015)
The neuro-protective effects of exercise in children treated
with cranial radiation for brain tumours. Mabbott DJ, Bartels U,
Treatment choices for children with typical acute immune
Bouffet E, Courneya K, Noseworthy M, Piscione J, Tabori U.
thrombocytopenic purpura: development of a decision aid.
Canadian Institutes of Health Research ($100,000 2010-2011)
Beck C, Parkin P, Birken C, Blanchette V, Boydell K, LlewellynThomas H. DeanтАЩs Fund New Staff Competition ($10,000
The Ontario Pediatric Oncology Clinical Trials Research Network.
2006-2011)
Blanchette V, Malkin D, Devine S, Baruchel S, Weitzman, S,
Bouffet E. Ontario Cancer Research Network ($1.2 million
Validation of the ChildrenтАЩs International Mucositis Evaluation
2006-2010)
Scale (ChIMES). Sung L, Beyene J, Feldman B, Tomlinson D.
Canadian Institutes of Health Research ($313,000 2010-2013)
The role of SBDS in promoting cell survival. Dror Y. Canadian
Institutes of Health Research ($250,000 2006-2011)
Weekly vinblastine for chemotherapy na├пve children with
progressive low grade glioma. Bouffet E, Pond G, Moghrabi A,
The role of VPS33B in platelet alpha granule formation.
Carret AS, Jabado N, Samson Y, Crooks B, Hand JP, Strother D,
Kahr WHA. Canadian Institutes of Health Research
Wilson B, Hukin J, Mpofu C, Whitton A, Zelcer S, Silva M,
($441,912 2006-2010)
Brossard J, Johnston D, Keene D, Bartels U, Tabori U, Hawkins C.
Ontario Institute of Cancer Research ($536, 885 2007-2010)
The roles of the novel p53 family proteins in cancer and
chemosensitivity. Irwin MS. Canada Research Chair
What factors are important for understanding quality of life in
($500,000 2008-2013)
children with cancer? Klaassen A, Dix D, OтАЩDonnell M, Pritchard S,
Raina P, Tucker L, Yanofsky R, Sung L. National Cancer
The utility of a pan-fungal PCR assay in detecting fungemia in
Institute of Canada ($35,000 2009-2010)
at-risk patients. Doyle J, Richardson S, Allen U. Paediatric
Consultants Grant ($9,772 2009-2010)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 109
Division Head
Dr. Chaim Roifman
Full-Time
Dr. Adelle Atkinson
Dr. Eyal Grunebaum
Dr. Julia Upton
Part-Time
Dr. Maria Asper
Dr. Stephen Feanny
Dr. David Hummel
Dr. Sasson Lavi
Clinical Assistant
Dr. Vy Kim
Dr. Nufar Marcus
Dr. Luis Murguia
Senior Scientist
Dr. Amos Cohen
Clinical Fellows
Dr. Nashat Al Sukaiti
Dr. Kyla Hildebrand
Dr. Melanie Makhija
Immunology and
allergy Nurses
Anne Kasprzak
Brenda Reid
Research Associate
Dr. Nigel Sharfe
Division of Immunology/Allergy
Divisional Overview
The Hypogammaglobulinemia Program at SickKids is recognized
The Division of Immunology and Allergy remains at the forefront
globally for its innovative approach and long-term follow up of
of innovation in primary immune deficiencies (PID). As the
over 200 patients. We transformed the therapy of these patients
founder and Director of the Canadian Centre for PID, Jeffrey
from multiple hospital-based admissions, to visits to the
Modell Centers Network and the Canadian Immunodeficiency
short-stay unit and eventually, treatment in their own community.
Society, Dr. Chaim RoifmanтАЩs national and international
The proficiency of our team, coupled with convenient care at a
programs support research, while facilitating early recognition,
medical centre close to home, provide our patients with the
diagnosis, and effective treatment of primary immune deficiencies.
personalized treatment they require. To further develop this
program, implementation of a home therapy program is
The Primary Immunodeficiency Program at SickKids is the
underway. Funding by the Canadian Immunodeficiency Society
largest of its kind in Canada and one of the largest in the world.
(CI Society) has permitted the completion of a provincial patient
Medical services are provided to over 2,000 outpatients referred
survey to assess such a model in Ontario. Final analysis is
from physicians and hospitals nationally. This number has
underway and a clinical trial is under development. As a leader
steadily increased by 30 percent over the last 10 years. With
in gammaglobulin treatment, Dr. Roifman acted as lead
a total of nine clinics per month, evaluation of our complex
investigator in multiple international clinical trials. As a result,
patients is enhanced by providing extensive time and attention
we have just completed a study of the efficacy and safety of
Omrigam, a novel form of IVIg, and are in the preparatory stages
to their conditions.
of participating in a Baxter Multicentre trial for subcutaneous
The Allergy Program at SickKids is a referral-based clinic for the
gammaglobulin infusions.
diagnosis and management of children with complex allergic
diseases, including multiple drug allergies, latex allergy,
Innovative protocols in stem cell and gene therapy, pioneered
anaphylaxis, food challenges, urticaria (chronic, idiopathic, cold/
at SickKids by Dr. Roifman, have positioned the Bone Marrow
heat induced, etc.), and asthma. To assess this diverse group,
Transplantation (BMT) Program as a benchmark world-wide.
three clinics are available to patients and families. They see
We have demonstrated that matched unrelated transplants are
900 patients a year, and 500 patients are referred to external
successful in 80 per cent of cases and are superior to other
clinics. This year was challenging due to the H1N1 pandemic,
modalities of BMT for multiple forms of PID (JAMA 2006;
causing an increased demand for the influenza vaccine in egg
Immunol Res 2007; BMT 2008). This year we demonstrated
allergic patients. Dr. Julia Upton, a physician in our Division,
its success in Omenn syndrome, which has proven to be even
along with the allergy team, managed to include a fourth H1N1
better than in other forms of SCID (Immunol Res 2009).
clinic, ensuring that all these additional high-risk patients were
Similarly, we have reported effective management of lung
vaccinated. This was a major achievement.
disease in partial ADA deficiency via PED-ADA therapy and
liver disease via immunosuppression (JACI 2009). Finally, we
described a rare adverse reaction of aplastic anemia following
varicella vaccine in a PID patient (Pediatr Infect Des J 2009).
Research
Technologists
Lorand Cimpeon
Tom Grunberger
Ariana Karanxha
Weixian Min
Murugesapillai Mylvaganam
Medical Lab
Technologists
Andrea Bates
Rachel Borlack
Harjit Dadi
Administrative Staff
Jayne Enhaynes
Sandra Mendonca
Canadian Centre
of PID and JMF
Centres Manager
Linda Pires
With such life-altering advancements in the care and quality
Advancements in gene and protein therapy were made in
of life of patients, Dr. Chaim Roifman, Division Head for 20
Dr. Eyal GrunebaumтАЩs laboratory. Using samples from adensoine
years, remains a member of the IUIS Committee for Primary
deaminase (ADA) deficient patients and mice, treated
Immunodeficiency (previously WHO). Here, he contributes to the
successfully with gene therapy, Dr. Grunebaum and his
creation of worldwide guidelines and classification for immune
colleagues were able to demonstrate the role of ADA in bone
deficiency (JACI 2009:124:1161-78). The Immunology and
development (Blood 2009). Furthermore, with The Chaim
Allergy Clinics of North America similarly recognized these
Roifman Scholar Award granted to Dr. Grunebaum in 2010 by
accomplishments as Dr. Chaim Roifman was guest editor for
the Canadian Immunodeficiency Society, Dr. GrunebaumтАЩs group
both 2010 volumes.
developed a novel method to deliver full-length ADA into cells,
providing hope for an effective alternative treatment for
Research remains an integral pillar of our Division. Under the
ADA-deficient patients. In addition, using normal and purine
guidance of Dr. Chaim Roifman, The Jeffrey Modell Research
nucleoside phosphorylase-deficient immune cells, before and
Laboratory for the Diagnosis of PID (Canadian Centre for PID)
after gene therapy, Dr. GrunebaumтАЩs lab developed a new
continues to thrive. In 2009, we performed 2,096 tests for the
method to assess responses of immune cells which avoided
evaluation of immunity in PID patients as well as 312 molecular
the use of radioactive material, thereby providing a safer tool to
sequences for possible immunodeficiency. Defining novel
evaluate immune responses (J Immunological Methods 2009).
phenotypes and genotypes of primary immunodeficiencies
With such outstanding advancements, it is no surprise that Dr.
remains the fundamental goal of this centre. As a result, we
Grunebaum was awarded the Fred Rosen/Jeffrey Modell/NIH
have characterized the pathophysiology and autoimmunity of
research grant in 2009.
Omenn syndrome (Blood 2009, JACI 2009), identified that
ADA-SCID bone manifestations are a product of a RANK/OPG
Education remains a major focus for every member of the
imbalance (Blood 2009), and discovered a novel phenotype of
Division. With a flawless certification record by the Royal College
combined immunodeficiency associated with facial dysmorphism,
of Physician and Surgeons of Canada since 1990, our program
optic nerve atrophy, skeletal abnormalities and developmental
provides exceptional training in clinical as well as laboratory
delay (Clinical Genetics 2009).
immunology. By preparing outstanding academic and nonacademic specialists in Immunology and Allergy, we continue
to attract over 25 brilliant candidates every year from across
the world. To accommodate these additional national and
international fellows, The CI Society-Talecris Fellowship Program
has supported our divison for over a decade. These trainees
have the opportunity to participate in a flexible program which
can be predominantly research oriented.
112
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Our commitment to education far exceeds these training
Thanks to the support of The Donald & Audrey Campbell
programs. As the Chair of the Jeffrey Modell Centers Network,
Chair, the Jeffrey Modell Foundation, the CI Society, Canadian
Dr. Chaim Roifman established The Robert A. Good/Jeffrey
Institutes of Health Research, March of Dimes, and the
Modell Fellowship in Immunodeficiency and Transplantation. This
Canadian Centre for Primary Immunodeficiency, children with
international program began in 2009 and provided matching
primary immunodeficiency are diagnosed earlier and receive
funds for several Immunology fellowship positions each year
state of the art treatment in a timely fashion.
globally. Our very own Amit Nahum was honoured in 2009 and is
now Assistant Professor of Paediatrics and Director of Immunology
Honours and Awards
at Kaplan Medical Centre in Israel. In addition, the Jeffrey Modell
Roifman CM, Dream Makers Award, Jeffrey Modell Foundation,
Canadian Immunodeficiency Network implemented Primary
New York, 2009.
Immunodeficiency Video Conference rounds. Since 2008, these
Royal College-accredited quarterly seminars, hosted by SickKids,
Atkinson A: Sarita Verma Award for Advocacy and Mentorship
link immunologists and trainees across Canada for discussions
in Postgraduate Medicine, 2010.
of complex cases. Participation is accessible through telehealth
video conferencing and web casting, with an average of 60
Atkinson A: Associate Professor, University of Toronto, 2009.
participants and nine national sites.
Grunebaum E, Associate Professor, University of Toronto, 2009.
Dr. Adelle Atkinson, now beginning her fifth year as the Director
of Post Graduate Education in the Department of Paediatrics,
Publications
continues to excel as an outstanding educator. In recognition
Angelini P, Kavadas F, Sharma N, Richardson SE, Tipples G,
of her achievements, she was promoted to Associate Professor
Roifman CM, Dror Y, Nofech-Mozes Y: Aplastic anemia following
in July 2009 and in the Spring of 2010, she received the Sarita
varicella vaccine. Pediatric Infectious Diseases Journal 2009:
Verma Award for mentorship and advocacy. Over the last year,
28(8): pp 746-748.
she has been invited to present at international conferences
in the area of postgraduate medical education and faculty
Griffith LM, Cowan MJ, Notarangelo LD, Puck JM, Buckley RH,
development on topics such as residency selection,
Candotti F, Conley ME, Fleisher TA, Gaspar B, Kohn DB, Ochs
professionalism, clinical teaching and feedback. Dr. Atkinson
HD, OтАЩReilly RJ, Rizzo D, Roifman CM, Small TN, Shearer WT:
runs a novel clinic studying drug allergies in medically complex
Improving cellular therapy for primary immune deficiency
patients, providing an important clinical service to this tertiary
diseases: Recognition, diagnosis and management. Journal of
care population.
Allergy and Clinical Immunology 2009: 124(6): pp 1152-1160.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 113
Nahum A, Reid B, Grunebaum M, Roifman CM: Matched
Somech R, Lai YH, Grunebaum E, Lesaux N, Cutz E,
unrelated bone marrow transplant for omenn syndrome.
Roifman CM: PEG-ADA improved lung disease but not liver
Immunologic Research 2009: 44: pp 25-34.
disease in partial ADA deficiency. Journal of Allergy and Clinical
Immunology 2009: 124(4): pp 848-850.
Notarangelo LD, Fischer A, Geha RS, Casanova JL, Chapel H,
Conley ME, Cunningham-Rundles C, Etzioni A, Hammartrom L,
Somech R, Simon AJ, Lev A, Dalal I, Spirer Z, Goldstein I,
Nonoyama S, Ochs HD, Puck JM, Roifman C, Seger R,
Nagar M, Amariglio N, Rechavi G, Roifman CM: Reduced
Wedgwood J: Primary immunodeficiencies: 2009 update.
central tolerance in Omenn syndrome leads to immature
International Union of Immunological Societies Expert
self-reactive oligoclonal T-cells. Journal of Allergy and
Committee on Primary Immunodeficiencies. Journal of Allergy
Clinical Immunology 2009: 124(4): pp 793-800.
and Clinical Immunology 2009: 124(6): pp 1161-1178.
Yu Y, Arora A, Min W, Roifman CM, Grunebaum E: EDU - Click
Poliani PL, Facchetti F, Ravanini M, Gennery A, Villa A,
flow cytometry as an alternative to 3H-thymidine for measuring
Roifman CM, Notarangelo LD: Early defects in human T cell
T cell proliferation. Journal of Immunological Methods 2009:
development severely affect distribution and maturation
350(1-2): pp 29-35.
of thymic stromal cells: Implications for the pathophysiology
of omenn syndrome. Blood 2009: 114: pp 105-108.
Books and Book Chapters
Grunebaum E, Candotti F: Immunodeficiency Due to Defects
Roifman CM, Chitayat D: Combined immunodeficiency, facial
of Purine Metabolism In Primary Immunodeficiency Diseases:
dysmorphism, optic nerve atrophy, skeletal anomalies and
A Molecular and Genetic Approach (Ochs HD, Smith E, Puck J,
developmental delay: A new syndrome. Clinical Genetics 2009:
eds.). Oxford University Press, New York, 2009.
76(5): pp 449-457.
Funding
Sauer AV, Mrak E, Hernandez RJ, Zacchi E, Cavani F,
A clinical study of the pharmacokinetics, efficacy and safety of
Casiraghi M, Grunebaum E, Roifman CM, Cervi MC, Ambrosi A,
immune globulin intravenous (human) Omr-IgG amтАЩ99 IGIV in
Carlucci F, Roncarolo MG, Villa A, Rubinacci A, Aiuti A:
subjects with primary immune deficient diseases. Grunebaum
Adenosine deaminase deficiency results in a bone phenotype
E, Somech R. FFF Enterprises ($55,000 2007-2009)
characterized by RANKL/OPG imbalance and osteoblasts
insufficiency. Blood 2009: 114(15): pp 3216-3226.
114
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
CI Society Talecris Treatment and Bone Marrow Transplant
Immune and non-immune abnormalities associated with purine
Centre for Primary Immunodeficiency. Roifman CM. Canadian
nucleoside Phosphorylase deficiency. Grunebaum E, Roifman
Immunodeficiency Society ($150,000 2009-2012)
CM. Jeffrey Modell Foundation/National Institutes of Health/
National Institute of Allergy and Infectious Diseases
Correcting PNP deficiency by intracellular delivery of PNP
($250,000 2009-2011)
fused to protein transduction domains. Grunebaum E.
US Immunodeficiency Network ($330,000 2006-2009)
Jeffrey Modell Centres Network. Roifman CM. Jeffrey Modell
Foundation ($15,000 2009)
Correcting purine nucleoside phosphorylase deficiency by
prolonged intracellular enzyme replacement therapy.
Jeffry Modell Canadain Immunodeficiency Network. Roifman CM.
Grunebaum E. March of Dimes ($390,000 2007-2010)
Canadian Immunodeficiency Society ($12,672 2009)
Epstein-Barr virus in health and disease in children and youth:
JMFRAG Research Fellowship. Roifman CM. Jeffrey Model
A prospective study of markers of virus-host interaction and
Foundation and Robert A Good Society ($37,500 2009)
genetic variation. Allen U, Beyenne J, Grunebaum E, Mazzulli T,
Read S, Robinson J, Tellier R, Weitzman S, Zielenska M.
Jeffrey Modell Research Laboratories for the diagnosis of
Canadian Institutes of Health Research ($398,968 2008-2012)
primary immunodeficiencies. Roifman CM. Jeffrey Modell
Foundation ($125,000 2009-2011)
Genetics of primary immunodeficiency. Roifman CM. Canadian
Immunodeficiency Society ($100,000 2007-2010)
Optimizing hematopoietic stem cell transplantation -the cord
advantage. Grunebaum E. Elizabeth Rose Herman Endowment
Home immunoglobulin therapy. Roifman CM. Canadian
Fund ($29,000 2008-2010)
Immunodeficiency Society ($430,000 2007-2011)
Talecris fellowship in Immunology. Roifman CM. Canadian
Immunodeficiency Society ($100,000 2009)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 115
Division Head
Dr. Upton Allen
Dr. Anupma Wadhwa
Dr. Valerie Waters
Dr. Stanley Read
Dr. Alana Rosenthal
Full-Time
Dr. Sean Ari Bitnun
Dr. Anne Opavsky
Dr. Dat Tran
Part-Time
Dr. Ian Kitai
Dr. Anne G. Matlow
Clinical Nurses
Debra Louch
Georgina MacDougall
Pat Malloy
Clinical Research
Nurse Coordinators
Cheryl Arneson
Kayleigh DтАЩAmour
Suganya Lee
Brenda OтАЩDoherty
Research Associates
Nasser Khodai Booran
Paul Pedulla
Social Worker
Robyn Salter
Division of Infectious Diseases
Divisional Overview
The Division continues to have a leadership role in structuring
The Division of Infectious Diseases is a leader in clinical,
the approach to the management of major emerging and
educational and research activities locally, nationally and
resurgent infectious disease threats. In this regard, the
internationally. The Division has active in-patient as well as
Division has been actively involved in influenza pandemic
ambulatory consultant services that include teams that focus
planning efforts at SickKids as well as provincially and
on general infectious diseases and infectious diseases in
nationally. Indeed, members of the Division had pivotal
immunocompromised infants, children and youth, respectively.
local, provincial, national and international leadership
We are a resource for issues related to infectious disease
roles in the H1N1 pandemic of 2009.
outbreaks, including new and emerging infectious, infection
control and the specialized areas of HIV, congenital infections,
In the area of education, representatives from our Division
management of infectious complications or organ
continue to play a key role in activities of the Royal College
transplantation, and the ever-increasing problem of
of Physicians and Surgeons of Canada, and in many areas
multi-drug resistant tuberculosis.
of undergraduate, graduate, post-graduate and continuing
medical education activities. Faculty members continue to
Division members have a leading role in national and
hold editorships, visiting professorships and related
international epidemiological, clinical, research advisory and
academic honours nationally and internationally.
related committees (e.g., the Infectious Diseases Society
of America, the Canadian Paediatric Society, Health Canada,
Honours and Awards
the American Society for Transplantation, the International
Pediatric Transplant Association and the Government of
the Bahamas).
Opavsky A: The coxsackie-adenovirus receptor in heart
infection and heart failure Heart and Stroke Foundation
Clinician Scientist Award ($166,000 2007-2010).
Our research initiatives are structured around themes that
include host susceptibility and related factors and innovative
Publications
antimicrobial and associated therapies. Specific research
Adam HJ, Louie L, Watt C, Gravel D, Bryce E, Loeb M, Matlow A:
initiatives include multi-centred paediatric HIV studies related
Canadian Nosocomial Infection Surveillance Program.
to maternal-to-child transmission and studies on new
Detection and characterization of heterogeneous vancomycin-
antiretrovirals, vaccine studies and research into the
intermediate Staphylococcus aureus isolates in Canada:
mechanisms of host susceptibility to viral infections. These
Results from CNISP, 1995-2006. Antimicrobial Agents and
infections include viral myocarditis, influenza illness, HIV,
Chemotherapy 2010: 54: pp 945-949.
EBV-related post-transplant lympoproliferative disorder (PTLD)
and encephalitis. Multicentred trials related to the diagnosis
Afzal S, Ethier M-C, Dupuis LL, Tang L, Punnett AS,
and prevention of infections in transplant patients are ongoing,
Richardson SE, Allen UD. Alba O, Sung L: Risk factors for
as well as participation in national surveillance studies
infection-related outcomes during induction therapy for
(IMPACT) and national collaborative paediatric studies through
childhood acute lymphoblastic leukemia. Pediatric Infectious
the Paediatric Investigators Collaborative Network on Infections
Diseases Journal 2009: 28(12): pp 1064-1068.
in Canada (PICNIC). Our research in infection control includes
the clinical and molecular epidemiology of paediatric
nosocomial infections.
Research Lab Staff
Sabah Asad
Cathy den Hollander
Michelle den Hollander
Danuta Kovach
Sharon Li
Annie Lu
Rinu Mathew
Reggie Peralta
Hilary Reddin
Kim Simpson
Julie Smith
Stella Yuen
Administrative Staff
Brenda Bishop
Savannah Hatt
Linda Martin
Bebi Wali
Allen UD: Epstein-Barr virus vaccination of transplant
Allen UD, members of the Infectious Diseases and
candidates: Light at the end of the tunnel. Transplantation
Immunization Committee, Canadian Pediatric Society:
2009: 88: pp 976-977.
Congenital syphilis: No longer just of historical interest.
Paediatrics & Child Health 2009: 14: p. 337.
Allen UD, Barton M, Beyene J, Hu P, Khodai-Booran N, H├йbert D,
Diphchand A, Ng V, Soloman M, Grant D, Fecteau A, Ngan B,
Allen UD, Onyett H, MacDonald N, Moore D, members of
Read S, Zielenska M, Weitzman S: Gene expression using
the Canadian Paediatric Society Infectious Diseases and
DNA microarrays in transplant recipients at risk of EBV
Immunization Committee. Questions and answers on pandemic
lymphoproliferation after organ transplantation: Preliminary
(H1N1) 2009 Influenza: The illness and antiviral drugs.
proof of concept. Pediatric Transplantation 2009: 13: pp
http://www.cps.ca/english/H1N1_IllnessAntiviral.htm
990-998. Accompanying editorial: Pediatric Transplantation
2009: 13: pp 944-947.
Allen UD, Onyett H, MacDonald N, Moore D, members of
the Canadian Paediatric Society Infectious Diseases and
Allen UD, Bow E, Doyle J, Richardson S, Robinson J, Rotstein C,
Immunization Committee. Pandemic influenza (H1N1) 2009
Davies D, Hui C, LeSaux N, Laverdiere M, Read S: Pediatric
and infection control controversies: Working with ongoing
antifungal therapy. Part I: Focus on febrile neutropenia,
change: Practice point. November, 2009 (http://www.cps.ca/
invasive aspergillosis, combination antifungal therapy and
english/H1N1_IllnessAntiviral.htm)
invasive candidiasis in immunocompromised pediatric patients.
Minerva Pediatrica 2010: 62: pp 57-69.
Allen UD, Onyett H, MacDonald N, Moore D, members of
the Canadian Paediatric Society Infectious Diseases and
Allen UD, Doucette K, Bow E: Guidance on the management of
Immunization Committee: Pandemic influenza (H1N1) 2009
mandemic H1N1 infection in immunocompromised individuals.
and infection control controversies: Dispelling myths held by
Available at http://www.ammi.ca/pdf/guidelineh1N1.pdf
parents about the influenza vaccine. Practice Point. November,
2009 http://www.cps.ca/english/H1N1_IllnessAntiviral.htm
Allen UD, Humar A, Limaye A, Miller R, Michaels M. Discipline
of transplant infectious diseases (ID). Foreword. American
Allen UD, Onyett H, MacDonald N, Moore D, members of
Journal of Transplantation 2009: 9(Suppl. 4): pp. S1-S2.
the Canadian Paediatric Society Infectious Diseases and
Immunization Committee: Questions and Answers on Pandemic
Allen UD, members of the Infectious Diseases and
(H1N1) 2009 Influenza: Protecting young babies from influenza:
Immunization Committee, Canadian Pediatric Society:
Practice Point. November, 2009 http://www.cps.ca/english/
Lyme disease in Canada: Q & A for paediatricians.
H1N1_IllnessAntiviral.htm
Paediatrics & Child Health 2009: 14: pp 103-105.
Allen UD, Onyett H, MacDonald N, Moore D, members of
Allen UD, members of the Infectious Diseases and
the Canadian Paediatric Society Infectious Diseases and
Immunization Committee, Canadian Pediatric Society:
Immunization Committee: Questions and answers on pandemic
The new influenza A Virus: A/Mexico/2009 (H1N1) practice
(H1N1) 2009 influenza: CanadaтАЩs eight-step vaccine safety
point for caregivers of children and youth. Paediatrics & Child
program: Vaccine literacy: Practice Point. November, 2009
Health 2009: 14: p 337.
http://www.cps.ca/english/H1N1_IllnessAntiviral.htm
118
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Allen UD, Preiksaitis J, the AST Infectious Diseases
Barton-Forbes M, OтАЩRiordan S, Read S, Allen UD.
Community of Practice: Epstein-Barr virus and post-transplant
Recommended screening and management plan for swine-
lymphoproliferative disorder in solid organ transplant recipients.
origin influenza A (H1N1) - Paediatric patients: Section 2 -
American Journal of Transplantation 2009: 9(Suppl. 4):
Treatment. Prepared for the Incident Management Team
pp S87-S96.
(Cindy Bruce-Barrett, Chair), Hospital for Sick Children
and the Ministry of Health and Long Term Care, Ontario
Allen U, the Influenza Management Team: H1N1 questions and
http://kidweb.sickkids.ca/pandemicflu/section.asp?s=
answers for immunocompromised and other high-risk children
Pediatric+Management+Documents&sID=27341
with chronic medical conditions. Hospital for Sick Children.
http://kidweb.sickkids.ca/pandemicflu/custom/
Annotation: With contributions by: Richardson S, Yau Y,
H1N1HighRiskQandA.pdf
Matlow A, Wray R. White D, and the Ontario Provincial
Pediatric Pandemic Planning Group.
Allen U, Richardson S, McGuire W, Bow E, Robinson J,
Rotstein C, Doyle J, Davies D, Hui C, LeSaux, N, Merchant P,
Bettinger JA, Sauve LJ, Scheifele DW, Moore D, Vaudry W,
Laverdiere M, Read S: Pediatric antifungal therapy. Part II:
Tran D, Halperin SA, Pelletier L: Pandemic influenza in
Neonatal infections. Minerva Pediatrica 2010: 62: pp 71-78.
Canadian children: A summary of hospitalized pediatric
cases. Vaccine 2010: 28(18): pp 3180-3184.
Barnett CP, Jaeggi E, Han RK, Nevo O, Keating S, Shannon P,
Bitnun A, Chitayat D: Unusual cardiac presentation of
Bitnun A, Read S, Tellier R, Petric M, Richardson S: Severe
congenital cytomegalovirus infection. Ultrasound in
acute respiratory syndrome associated coronavirus infection
Obstetrics and Gynecology 2010: 35: pp 119-120.
in Toronto children: A second look. Pediatrics 2009: 123:
pp 97-101.
Barton M, Wasfy S, Dipchand A, H├йbert D, Ng V, Solomon M,
Fecteau A, Stephens D, Allen UD: Seven-valent pneumococcal
Bitnun A, Richardson SE: Mycoplasma pneumoniae: Innocent
conjugate vaccine in pediatric solid organ transplant recipients:
bystander or a true cause of central nervous system disease.
A prospective study of safety and immunogencity. Pediatric
Current Infectious Disease Reports 2010: 12: pp 282-290.
Infectious Diseases Journal 200: 28: pp 688-692.
Bogue CO, Leahy TR, Rea DJ, Bitnun A, Brandao LR, Khar WH,
Barton-Forbes M, OтАЩRiordan S, Read S, Allen UD:
Jacobson S, Amaral JG, Connolly BL: Idiopathic suppurative
Recommended screening and management plan for swine-
pylephlebitis: Intervention radiological diagnosis and
origin influenza A (H1N1) - Paediatric patients: Section 1 -
management. Cardiovascular and Interventional Radiology
Screening. Prepared for the Incident Management Team
2009: 32(6): pp 1304-1307.
(Cindy Bruce-Barrett, Chair), Hospital for Sick Children
and the Ministry of Health and Long Term Care, Ontario
Caruso L, Yuen S, Smith J, Husain M, Opavsky MA:
http://kidweb.sickkids.ca/pandemicflu/section.asp?s=
Cardiomyocyte-targeted overexpression of the coxsackie-
Pediatric+Management+Documents&sID=27341
adenovirus receptor causes a cardiomyopathy in association
with beta-catenin signaling. Journal of Molecular and
Annotation: With contributions by: Richardson S, Yau Y,
Cellular Cardiology 2010: 48: pp 1194-1205.
Matlow A, Wray R. White D, and the Ontario Provincial
Pediatric Pandemic Planning Group.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 119
Coffey M, Mack L, Bishara T, De Faveri L, Matlow A:
Jaworsky D, Thompson C, Yudin MH, Bitnun A, Brophy J,
Prevalence and clinical significance of medication
Samson L, Antoniou T, Loutfy MR: Use of newer antiretroviral
discrepancies at pediatric hospital admission.
agents, darunavir and etravirine with or without raltegravir,
Academic Pediatrics 2009: 9(5): pp 360-365.
in pregnancy: A report of two cases. Antiviral Therapy 2010:
15(4): pp 677-680.
Coffey M, Cornish P, Koonthanam T, Etchells E, Matlow A:
Implementation of admission medication reconciliation at two
Kalpoe JS, Shoham S, Reid GE, Humar A, on behalf of the
academic health sciences centres: Challenges and success
American Society of Transplantation H1N1 Collaborative
factors. Healthcare Quarterly 2009: 12: pp 102-109.
Study Group. A multicenter study of outcomes from pandemic
influenza A/H1N1 infection in solid organ transplant recipients.
Gray TL, Ooi CY, Tran D, Traubici J, Gerstle JT, Sung L:
Lancet Infectious Diseases 2010: 10: pp 521-526.
Gastrointestinal complications in children with acute myeloid
leukemia. Leukemia and Lymphoma 2010: 51(5): pp 768-777.
Kasiske BL, Zeier MG, Craig JC, Ekberg H, Garvey CA,
Green MD, Vivekanand J, Josephson MA, Kiberd BA, Kreis HA,
Green M, Allen UD: H1N1 influenza A 2009 and pediatric
McDonald RA, Newmann JM, Obrador GT, Chapman JR,
transplantation: Lessons learned and to be learned. Pediatric
Vincenti FG, Balk EM, Wagner M, Raman G, Abariga S, Earley A,
Transplantation 2009: December 22 [Epub ahead of print].
Allen UD: Kidney Disease: Improving Global Outcomes (KDIGO)
Transplant Work Group: Clinical practice guideline for the care
Greenberg DP, Doemland M, Bettinger JA, Scheifele DW,
of kidney transplant recipients. American Journal of
Halperin SA, IMPACT Investigators, Waters V, Kandola K:
Transplantation 2009: 9(Suppl. 3): pp S1-155.
Epidemiology of pertussis and Haemophilus influenzae type b
disease in Canada with exclusive use of a pediatric DTaP-IPV/
Kotton CN, Kumar D, Caliendo AM, Asberg A, Chou S,
Hib combination vaccine and adolescent-adult Tdap vaccine:
Snydman DR, Allen UD. Humar A, on behalf of The
Implications for disease prevention in the US. The Pediatric
Transplantation Society International CMV Consensus Group:
Infectious Diseases Journal 2009: 28(6): pp 521-528.
International consensus guidelines on the management of
Hajek J, Yau Y, Kertes P, Soman T, Laughlin S, Kanani R,
2010: March 10 [Epub ahead of print].
cytomegalovirus in solid organ transplantation. Transplantation
Kazacos K, Dangoudoubiyam S, Opavsky MA: A child with
raccoon roundworm meningoencephalitis: A pathogen emerging
Kumar D, Michaels MG, Morris M, Green M, Avery R, Liu C,
in your own backyard? Canadian Journal of Infectious Diseases
Danziger-Isakov L, Stosor V, Estabrook M, Gantt S, Marr KA,
and Medical Microbiology 2009: 20: pp e177- e180.
Martin S, Silveira FP, Razonable RR. Allen UD, Levi ME,
Lyon GM, Bell LB, Huprikar S, Patel G, Gregg K, Pursell K,
Hawkes M, Richardson SE, Ipp M, Schuh S, Adachi D, Tran D:
Helmersen D, Julian K, Shiley K, Bono B, Dharnidharka VR,
Sensitivity of rapid influenza diagnostic testing for Swine-Origin
Alavi G, Kunimoto D, Gardam M, Kitai I, Menzies D, Morshed M,
2009 A (H1N1) influenza virus in children. Pediatrics 2010:
Pai M, Ward H, Webster D, Wobeser W, Canadian Tuberculosis
125(3): pp 639-644.
Committee: Recommendations on interferon gamma release
assays for the diagnosis of latent tuberculosis infection - 2010
Update. Canadian Communicable Disease Report 2010:
36(ACS-5): pp 1-21.
120
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Kumar D, Morris MI, Kotton CN, Fischer SA, Michaels MG,
Matlow A, Moody L, Laxer R, Stevens P, Goia C, Friedman JN:
Allen UD. Blumberg EA, Green M, Humar A, Ison MG, on behalf
Disclosure of medical error to parents and pediatric patients:
of the AST Infectious Diseases Community of Practice and
Assessment of parentsтАЩ attitudes and influencing factors.
Transplant Infectious Diseases Section of TTS: Guidance on
Archives of Disease in Childhood 2010: 95: pp 286-290.
novel influenza A/H1N1 in solid organ transplant recipients.
American Journal of Transplantation 2010: 10(1): pp 18-25.
Murkerji A, Sulowski C, Friedman JN, Opavsky A: Salmonella
Poona maternal mastitis causing neonatal meningitis. The
Kumar D, Michaels MG, Morris M, Green M, Avery R, Liu C,
Pediatric Infectious Disease Journal 2009: 12: pp 1141-1142.
Danziger-Isakov L, Stosor V, Estabrook M, Gantt S, Marr KA,
Martin S, Silveira FP, Razonable RR. Allen UD, Levi ME,
OтАЩRiordan S, Barton M, Yau Y, Read SE, Allen UD. Tran D.
Lyon GM, Bell LB, Huprikar S, Patel G, Gregg K, Pursell K,
Risk factors and outcomes among children admitted to
Helmersen D, Julian K, Shiley K, Bono B, Dharnidharka VR,
hospital with pandemic H1N1 influenza. Canadian Medical
Alavi G, Kalpoe JS, Shoham S, Reid GE, Humar A, on behalf of
Association Journal 2010: 182(1): pp. 39-44.
the American Society of Transplantation H1N1 Collaborative
Study Group: A multicenter study of outcomes from pandemic
Ota KV, Dimaras H, Heon E, Babyn PS, Yau, YCW, Read S,
influenza A/H1N1 infection in solid organ transplant recipients.
Budning A, Gallie BL, Chan HSL: Toxocariasis mimicking liver,
Lancet Infectious Diseases 2010: 10: pp 521-526.
lung, and spinal cord metastases from retinoblastoma. The
Pediatric Infectious Disease Journal 2009: 28: pp 1-2.
Leahy TR, Punnett AS, Richardson SE, Gharabaghi F,
Wadhwa A: Alternaria infectoria in a patient with AML -
Pau WS, AlSaffar H, Weinstein M, Kitai I: Sporotrichoid-like
a case report. Diagnostic Microbiology and Infectious
tuberculosis. Pediatric Infectious Diseases Journal 2009: 28:
Disease 2010: 66 (3): pp 318-321.
pp 1135-1136.
Mahant S, Cohen E, Weinstein M, Wadhwa A: Treatment of
Plevneshi A, Svoboda T, Armstrong I, Tyrrell GJ, Miranda A,
pleural empyema in children: A systematic review of RCTs.
Green K, Low D, McGeer A. Kitai I, Toronto Invasive Bacterial
Archives of Pediatrics and Adolescent Medicine 2010: 164:
Diseases Network: Population-based surveillance for invasive
pp 201-203.
pneumococcal disease in homeless adults in Toronto. PLoS
One 2009: 4(9): p e7255.
Manlhiot C, Pollock-Barziv SM, Holmes C, Weitzman S,
Allen UD, Clarizia NA, Ngan BY, McCrindle BW, Dipchand AI:
Scheinemann K, Ethier MC, Dupuis LL, Richardson SE, Doyle J,
Post-transplant lymphoproliferative disorder in pediatric
Allen UD. Sung L : Utility of peripheral blood cultures in
heart transplant recipients. Journal of Heart and Lung
bacteremic pediatric cancer patients with a central line.
Transplantation 2010: 29: pp 648-657.
Support Care Cancer. 2009: August 29 [Epub ahead of print].
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 121
Shi Y, Fukuoka M, Li G, Liu Y, Chen M, Konviser M, Chen X,
Vayalumkal JV, Gravel D, Moore D, Matlow A, and the Canadian
Opavsky MA, Liu PP: Regulatory T cells protects mice against
Nosocomial Infection Surveillance Program Surveillance for
Coxsackievirus-induced Myocarditis through TGF╬▓-CAR pathway.
Healthcare-Associated Febrile Respiratory Infections in
Circulation 2010: 121: pp 2624-2634.
Pediatric Hospitals participating in the Canadian Nosocomial
Simor AE, Gilbert NL, Gravel D, Mulvey MR, Bryce E, Loeb M,
acquired febrile respiratory infection in pediatric hospitals
Matlow A, MCGeer A, Louie L, Campbell J, Canadian
participating in CNISP. Infection Control and Hospital
Nosocomial Infection Surveillance Program: Methicillin-
Epidemiology 2009: 30(7): pp 652-658.
Infection Surveillance Program: Surveillance for healthcare-
resistant Staphylococcus aureus colonization or infection in
Canada: National Surveillance and Changing Epidemiology,
Walkty A, Boyd DA, Gravel D, Hutchinson J, McGeer A, Moore D,
1995-2007. Infection Control and Hospital Epidemiology 2010:
Simor A, Suh K, Taylor G, Miller M, Mulvey MR, Canadian
31(4): pp 348-356.
Nosocomial Infection Surveillance Program: Molecular
characterization of moxifloxacin resistance from Canadian
Simor AE, Louie L, Watt C, Gravel D, Mulvey MR, Campbell J,
Clostridium difficile clinical isolates. Diagnostic Microbiology
McGeer A, Bryce E, Loeb M, Matlow A: The CNISP antimicrobial
and Infectious Disease 2010: 66(4): pp 419-424.
susceptibilities of healthcare-associated and communityassociated strains of methicillin-resistant Staphylococcus
Wang Q, Babyn P, Branson H, Tran D, Davilla J, Mueller EL:
aureus (MRSA) from hospitalized patients in Canada, 1995-
Utility of MRI in the follow-up of pyogenic spinal infection in
2008. Antimicrobial Agents and Chemotherapy 2010: 54(5):
children. Pediatric Radiology 2010: 40(1): pp 118-130.
pp 2265-2268.
Waters V, Jamieson F, Richardson S, Ford-Jones L,
Tan M, Armstrong D, Birken K, Bitnun A, Caldarone C, Cox P,
Finkelstein M, Wormsbecker A, Halperin S: Case control
Kahr W, MacGregor D, Askalan R: Bacterial endocarditis in a
study of a pertussis outbreak in Toronto from October
child presenting with acute arterial ischemic stroke;
2005-March 2006. The Pediatric Infectious Disease
should thrombolytic therapy be absolutely contraindicated.
Journal 2009: 28(7): pp 582-587.
Developmental Medicine and Child Neurology 2009: 51:
pp 151-154.
Waters V, Jamieson F, Richardson S, Ford-Jones L, Finkelstein M,
Wormsbecker A, Halperin S. What is the significance of a high
Tan D, Asztelos E, Douglas D, Read S, Bitnun A: Congenital
cycle threshold positive IS481 PCR for Bordetella pertussis?
transmission of HIV, CMV and Toxoplasma gondii in a
(Reply to letter to the editor). The Pediatric Infectious Disease
premature infant. Pediatric Infectious Disease Journal 2009:
Journal 2009: 28(12): pp 1143-1144.
28: pp 1129-1131.
122
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Books and Book Chapters
Funding
Allen UD: Clinical features and diagnosis of post transplant
An IHPREG pilot study: Feasibility of the Ontario HIV pre-
lymphoproliferative disorders. In: Clinical features and
conception cohort study. Loutfy M, Angel J, Carvalhal A,
diagnostic evaluation of post transplant lymphoproliferative
Murphy K, Serghides L, Bayoumi A, Greene S, Newmeyer T,
disorder. In: Post-Transplant Lymphoproliferative Disorders
Smaill F, Bitnun A, Margolese S, Raboud J, Yudin M, Brophy J,
(Dharnidharka VR, Green M, Webber, eds.). Springer Publishers,
Masinde K, Rosenthal K. Canadian Institutes of Health
Heidelberg, Dordrechrt, London, New York, 2010.
Research ($96,075 2010-2011)
Allen UD, Green M: Prevention and treatment of infections
A pilot study of genetic determinants of severe influenza in
after pediatric solid organ transplantation. In: Optimization
children. Tran D, Paterson A, Beyene J, Richardson S, Schuh S.
of Ouctomes for Children after Solid Organ Transplantation
University of Toronto DeanтАЩs Fund - New Staff Grant ($10,000
(Ng V, Fend S, eds.). Pediatric Clinics of North America,
2007-2012)
Philadelphia, 2010.
Assessing the breadth and depth of cystic fibrosis-associated
Allen UD: Practice point: A pregnant patient with a previous
polymicrobial respiratory tract infections. Guttman D, Waters V.
pregnancy complicated by group B streptococcal disease. In:
Canadian Institutes of Health Emerging Team Grant
Infectious Diseases, 3rd Edition (Armstrong D, Cohen J, eds.).
(2,500,000 2010-2015)
Mosby International, London, UK, 2010.
A study of an HPV VLP vaccine in a cohort of HIV positive
Bridge M, Freeman S, Bitnun A: Infectious diseases. In: The
girls and women. Money D, Bitnun A, Dobson S, Kollmann T,
Hospital for Sick Children Handbook of Pediatrics, 11th Edition
Ogilvie G, Raboud J, Stuart G, Wobeser W, Cote H, Forbes J,
(Dipchand A, Friedman J, Bismilla Z, Gupta S, Lam C, eds.).
Krajden M, Petric M, Rachlis A, Coutlee F, Klein M, Loutfy M,
Saunders Elsevier Canada, Toronto, 2009.
Pick N, Smaill F, Walmsley S. Canadian Institutes of Health
Research ($646,068 2008-2010)
Rosenthal AJ, Matlow A, Wray R, Streitenberger L, Freeman R,
Cardamone K: Pediatrics. In: Association for Professionals
Defining the role of Stenotrophomonas maltophilia in cystic
in Infection Control and Epidemiology (APIC) Text of Infection
fibrosis patients. Waters V. Canadian Cystic Fibrosis
Control and Epidemiology, 3rd Edition, Volume II (Curchoe R,
Foundation ($81,290 2009-2011)
ed.,). APIC, Washington, 2009.
Does complicated pneumonia lead to chronic lung disease?
Wadhwa A: Infectious diseases. In: Manual of Pediatric
Cohen E, Weinstein M, Mahant S, Dell Sh, Traubici J,
Intensive Care, 1st Edition (Kirpalani HM, Huang L,
Wadhwa A. Pediatric Consultants Grant ($9,900 2010-2011)
Michenko M, Duffett M, eds.). PMPH-USA, Shelton, CT, 2009.
Effect of omega-3 fatty acid supplementation on
hypertriglyceridemia in HIV-infected children taking highly active
antiretroviral therapy (HAART): A randomized cross-over study.
Bitnun A, Read S, Brophy J. Canadian Foundation for HIV/AIDS
Research ($25,000 2008-2010)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 123
Effect of omega-3 fatty acid supplementation on
Heart failure and the coxsackie-adenovirus receptor (CAR):
hypertriglyceridemia in HIV-infected children taking highly active
Insights through a novel heart targeted CAR transgenic mouse.
antiretroviral therapy (HAART): A randomized cross-over study.
Opavsky MA. Heart and Stroke Foundation Grant-in-Aid
Read S, Bitnun A, Brophy J. Physicians Services Incorporated
($278,151 2007-2010)
Foundation ($32,000 2008-2011)
Immunogenicity of Arepanrix (AS-03-adjuvanted H1N1
Effect of omega-3 fatty acid supplementation on
pandemic influenza vaccine) in HIV-infected children.
hypertriglyceridemia in HIV-infected children taking highly active
Brophy J., Bitnun A, Read S. Canadian Foundation for
antiretroviral therapy (HAART): A randomized cross-over study.
AIDS Research ($22,800 2009-2010)
Bitnun A, Read S, Brophy J. Abbott Laboratories Ltd. ($40,500
2008-2009)
Interferon gamma release assays in immunocomprised
children: A pilot study. Kitai I, Bitnun A, Read S. Paediatric
Enhancing patient safety using web based simulation project.
Consultants Grant ($9620 2009-2011)
Glover-Takahashi S, Matlow A, Tallett S, Bandiera G, McIlroy J.
Network for Excellence in Simulation for Clinical Teaching
PHAC/CIHR Influenza Research Network (PCIRN). Halperin S,
and Learning ($50,000 2009)
Bortolussi R, Collett J-P, De Serres G, Kwong JJ, McNeil S,
Scheifele D, Ward B, Upton A, the PCIRN InvestigatorsтАЩ Group.
Epstein-Barr virus in health and disease in children
Public Health Agency of Canada/Canadian Institutes of
and youth: A prospective study of markers of virus-host
Health Research ($13,474,459 2008-2011)
interaction and genetic variation. Upton A, Beyene J,
Mazzulli T, Robinson J, Read S, Grunebaum E, Zielenska M,
Preclinical characterization of multmetric ribozymes as
Tellier R, Weitzman S. Canadian Institutes of Health
potential preventive and therapeutic agents for HIV infection.
Research ($398,968 2008-2012)
Joshi S, Read S. Canadian Institutes of Health Research
(236,234 2009-2012).
Genetic determinants of influenza severity in children: A
pre-pandemic community-based feasibility study. Tran D,
Predicting the risk of infection in children receiving
Beyene J, Bitnun A, Ipp M, Paterson A, Richardson SE.
chemotherapy for acute myeloid leukemia. Sung L, Allen U,
Canadian Institutes of Health Research ($99,919 2008-2009)
Beyene J. Canadian Institutes of Health Research
($817,963 2008-2012)
Genetic predictors of severe respiratory illness from pandemic
H1N1 influenza infection. Tran D, Paterson A. Public Health
Agency of Canada ($99,930 2010-2011)
124
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Primary EBV infection in the immnosuppressed setting of organ
The mechanism and immunological correlates of severe
transplantation: Determinants of the outcomes of virus-host
respiratory illness following 2009 H1N1 pandemic influenza
interaction. Allen UD, Beyene J, Dipchand A, Grunebaum E,
virus infection. Sharma S, Haeryfar SMM, Hancock REW,
Hebert D, Husain S, Mazulli T, Ng V, Read S, Robinson J,
Sahai BM, Tran D, Alexander M, Gubbay JB, Halperin SA, Lin F,
Tellier R, Weitzman S. Canadian Institutes of Health Research
Loeb MB, McGeer AJ, Palaniyar N, Paterson AD. Canadian
($488,265 2010-2014)
Institutes of Health Research ($300,000 2009-2010).
RSV Infection among transplant recipients and other high-risk
The psychosocial experiences and needs of HIV-positive women
compromised hosts. Allen UD, Robinson J. Abbott Canada
during their first year of motherhood. Greene S, Loutfy M,
($236,000 2008-2010)
Carvalhal A, Bitnun A, Brophy J, Kapiriri L, Margolese S,
Randomized double blind controlled trial of the use of a
Yudin M. Ontario HIV Trials Network ($450,000 2010-2013)
Masinde K, Murphy K, Raboud J, Salter R, Samson L, Smaill F,
biofilm antimicrobial susceptibility assay to guide antibiotic
therapy in chronic Pseudomonas aeruginosa infected cystic
The utility of pan-fungal PCR in detecting fungemia in at-risk
fibrosis patients (Hospital for Sick Children and St MichaelтАЩs
pediatric patients. Doyle J, Richardson S, Upton A. Paediatric
Hospital). Waters V. Innovotech Inc./National Research
Consultants Grant ($9772 2009)
Council Industrial Research Assistance Program
($200,000 2009-2012)
Understanding the HIV-Related transitions of families living
with HIV. Browne O, Bitnun A, Read S, Loutfy M, George C.
Severe influenza in children: Genetic determinants and
Ontario HIV Trials Network ($110,040 2009-2011)
related epidemiology. Tran D, Paterson A, Beyene J,
Richardson S, Schuh S, Roifman C. SickKids Foundation
Vitamin D supplementation and CD4 count in HIV-infected
($129,893 2008-2010)
children. Bitnun A, Read S, Kakalia S, Sochett E. Canadian
Foundation for HIV/AIDS Research ($24,997 2008-2009)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 125
Division Head
Dr. Shoo Lee
The Hospital for Sick
Children
Full-Time
Dr. Jacques Belik
Dr. Jonathan Hellmann
Dr. Andrew James
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Kyong-Soon Lee
Linh Lee
Patrick McNamara
Aideen Moore
Keith Tanswell
Christopher Tomlinson
Hilary Whyte
Part-Time
Dr. Rosemary Moodie
Adjunct
Dr. Xiaoping Luo
Cross Appointees
Dr. Bonnie Stevens
Honorary Faculty
Dr. Max Perlman
Dr. Paul Swyer
Dr. Arne Ohlsson
Division of Neonatology
Divisional Overview
The integrated University of Toronto Neonatal Follow-Up
The Division of Neonatology welcomes Dr. Simone Vaz to
Program was established under the leadership of Dr. Elizabeth
the faculty at Mount Sinai Hospital and Dr. Eugene Ng as a
Asztalos. The program will integrate the neonatal follow-up
full-time faculty member at Sunnybrook Health Sciences Centre
programs at the three NICUs (Mount Sinai, SickKids,
and Dr. Shoo Lee, who was appointed Chief of the Department
Sunnybrook). Dr. Edmond Kelly (Mount Sinai), Dr. Linh Ly
of Newborn and Developmental Paediatrics at Sunnybrook
(SickKids) and Dr. Paige Church (Sunnybrook) were appointed
Health Sciences Centre.
Directors of the Neonatal Follow-Up Clinics at their respective
The Division of Neonatology wishes to thank Dr. Rosemary
adopted at all follow-up clinics. New clinics will be established
Moodie, Dr. Shaheen Doctor and Dr. Maggie Shu for their
at SickKids and Mount Sinai to replace the joint follow-up
service and significant contributions and they deserve our
clinic at SickKids.
hospitals. A common neonatal follow-up protocol will be
enormous thanks and best wishes.
The DivisionтАЩs Neonatal-Perinatal Fellowship Training Program
The three level III NICUs at The Hospital for Sick Children,
continues to train the largest number of subspecialty trainees
Mount Sinai Hospital and WomenтАЩs College Hospital site
in neonatology of any centre in Canada, under the leadership
continue to suffer from a shortage of sufficient level III NICU
of Program Director, Dr. Martin Skidmore.
beds to adequately meet the maternal and neonatal needs
of our catchment area, which has continued to result in
The Division established the new Clinician-Scientist Scholar
regrettable deferrals of patients out of region, province
Training Program under the leadership of Dr. Robert Jankov. The
and country. The Ministry of Health and Long-Term Care
program is designed for neonatal fellows who have completed
commissioned a Neonatology Task Force, with province-wide
the Royal College-required training program in neonatal
representation including representatives from the three Toronto
perinatal medicine and are interested in pursuing further
NICUs, to address the issue of current level III NICU bed
research training to establish a career in research. The
requirements across the province, and the predicted increase
inaugural candidate in the program is Dr. Constance Williams.
in requirements over the next 10тАУ15 years. This was delivered
in 2007. The Ministry of Health and Long-Term Care responded
The Maternal-Infant Care (MICare) Research Centre was
by announcing 28 additional neonatal beds for the province,
established at Mount Sinai Hospital. The centre coordinates
including three additional NICU beds for Mount Sinai and three
several national and international research networks and will
for SickKids. All six additional beds have been opened.
also provide research support to members of the Division,
Mount Sinai Hospital was awarded the Ontario Human Milk
and methodologic consultations, database establishment and
Bank, and will be establishing it in partnership with SickKids
maintenance, computer programming and other support.
including research nurses and coordinator support, statistical
and Sunnybrook Health Sciences Centre. The Milk Bank will
be led by Dr. Sharon Unger. It will be the first in Ontario and
The Division continues to be well supported by major funding
one of only two in Canada.
agencies for its various foci at the three sites, including lung
biology, epidemiology, outcomes-based research and clinical trials.
This year we had 112 publications, and received grant funding
of $126,992,072. This represents increase of 31% and 54.8%
respectively compared to previous year.
Mount Sinai Hospital
Dr. Olufunmi Akindele
Dr. Yenge Diambomba
Dr. Emer Finan
Dr. Ann Jefferies
Dr. Edmond Kelly
Dr. Karel OтАЩBrien
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Prakesh Shah
Vibhuti Shah
Maggie Shu
Sharon Unger
Constance Williams
Kin Fan Young Tai
part-time
Dr. Simone Vaz
St. JosephтАЩs Hospital
Dr. Dilip Mehta
St. MichaelтАЩs Hospital
Dr. Tony Barozzino
Dr. Douglas Campbell
Dr. Michael Sgro
Dr. Ethel Ying
Sunnybrook Health
Sciences Centre
Full-Time
Dr. Elizabeth Asztalos
Dr. Paige Church
Dr. Michael Dunn
Honours and Awards
Banihani R: Award for Poster Presentation, CPS Annual
Asztalos E: Associate Professor, Department of Obstetrics
Meeting, Vancouver, BC, June 2010.
and Gynecology, Faculty of Medicine, University of Toronto,
November 2009.
Banihani R, Khurshid F, Al-Wassia H, Asztalos E, Shah P,
Doctor S: Medical Director, Neonatal Intensive Care Unit,
of neonates born at the limits of viability inborn vs outborn centres.
Moore A, Whyte H, Lee KS: Mortality rates and NICU outcomes
North York General Hospital, 2010-Present.
Ben Fadel N: Audrey Tan-Dy Humanitarian Award, NeonatalJefferies A: Excellence in Teaching Award, Neonatal-Perinatal
Perinatal Medicine Fellowship Training Program, University
Division, University of Toronto, June 2010.
of Toronto, 2010.
Lee K-S: Interim Clinical Director, NICU, Hospital for Sick
Lewis J: Trainee of the Year Award, Neonatal-Perinatal Medicine
Children, June-September 2009.
Fellowship Training Program, University of Toronto, 2010.
Lee S: Chief, Department of Newborn and Developmental
Publications
Paediatrics, Sunnybrook Health Sciences Centre, 2010.
Aimone A, Rovet J, Ward W, Jefferies A, Campbell DM,
Asztalos E, Feldman M, Vaughan J, Westall C, Whyte H,
Moore A: BORN (Better Outcomes Registry Network) Ontario
OтАЩConnor DL, Post-Discharge Feeding Study Group: Growth
Congenital Anomalies Surveillance Committee Leader, 2010.
and body composition of human milk-fed premature infants
Ng N: Deputy Chief, Department of Newborn and
discharge: One year follow-up. Journal of Pediatric
Developmental Paediatrics, Sunnybrook Health Sciences
Gastroenterology and Nutrition 2009: 49(4): pp 456-466.
provided with extra energy and nutrients early after hospital
Centre, 2010.
Azrapoozah A, Shah PS, Tenenbaum H, Goldberg MB:
Shah V: Karen McGibbon Award of Excellence тАУ Seymor Schulich
Photodynamic therapy for periodontitis: a systematic review
Honorarium Awarded for Excellence in Innovation, 2010.
and meta-analysis. Journal of Periodontology 2010: 81: pp 4-14.
Unger S: Women of Distinction Koeffler Foundation (Honoree),
Bassler D, Stoll BJ, Schmidt B, Asztalos EV, Roberts RS,
Mount Sinai Hospital, 2009.
Robertson CMT, Sauve RS, for the Trial of Indomethacin
Williams C: Canadian Institutes of Health Research Doctoral
neonatal morbidities to predict poor outcome in extremely
Award тАУ Frederick Banting and Charles Best Canada Graduate
low birth weight infants: Added role of neonatal infection.
Scholarship, April 2010.
Pediatrics 2009: 123(1): pp 313-318.
Prophylaxis in Preterms Investigators: Using a count of
Williams C: JKR Wightman Scholarship in Ethics from the
Belik J, Stevens D, Pan J, McIntyre BAS, Kantores C,
Royal College of Physicians and Surgeons, for paper entitled:
Ivanovska J, Xu EZ, Ibrahim C, Panama BK, Backx PH,
тАЬShared Decision Making in the NICU: the Virtuous TriadтАЭ.
McNamara PJ, Jankov RP: Pulmonary vascular and cardiac
effects of peroxynitrite decomposition in newborn rats. Free
Radical Biology & Medicine 2010: 49(8): pp 1306-1314.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Robert Jankov
Eugene Ng
Andrew Shennan
Brian Simmons
Martin Skidmore
Adrian Ziino
Part-Time
Dr. Shaheen Doctor
Dr. Eugene Ng
Clinical Fellows
Dr. Fouad Abou-Nahia
Dr. Suhair Al-Shanteer
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Mai Al-Qubaisi
Haytham Al-Khawaja
Eyad Al-Midani
Haydi Alwassia
Rudaina Banihani
Nadya Ben Fadel
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Hrolfur Brynjarsson
Poorva Deshpande
Christine Drolet
Afif El Khuffash
Julie Emberley
Julia Edwards
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Habib Haddad
Omer Hamud
Amish Jain
Faiza Khurshid
Emad Khadawardi
Ana Teresa Leslie
Belik J, Stevens D, Pan J, Shehnaz D, Ibrahim C, Kantores C,
Bould MD, Hayter MA, Campbell DM, Chandra DB, Joo HS,
Ivanovska J, Grasemann H, Jankov RP: Chronic hypercapnia
Naik VN: Cognitive aid for neonatal resuscitation: A prospective
down-regulates arginase expression and activity and increases
single-blinded randomized controlled trial. British Journal of
pulmonary arterial smooth muscle relaxation in the newborn
Anaesthesia 2009: 103(4): pp 570-575.
rat. American Journal of Physiology: Lung, Cellular and
Boutros J, Regier M, Skarsgard ED, Canadian Pediatric
Molecular Physiology 2009: 297: pp L777-L784.
Surgery Network: Is timing everything? The influence of
Belik J, Gema E, Gonz├бlez L, Vizcaino FP, Villamor E:
gestational age, birth weight, route, and intent of delivery on
Isoprostanes in fetal and neonatal health and disease.
outcome in gastroschisis. Journal of Pediatric Surgery 2009:
Free Radical Biology and Medicine 2010: 48: pp 177-188.
44(5): pp 912-917.
Belik J, Jerkic M, McIntyre BAS, Pan J, Leen J, Toporsian M,
Bradley TJ, Potts JE, Lee SK, Potts MT, De Souza AM,
Letarte M: Age-dependent endothelial nitric oxide synthase
Sandor GGS: Early changes in the biophysical properties
uncoupling in pulmonary arteries of endoglin heterozygous
of the aorta in pre-adolescent children born small for
mice. American Journal of Physiology: Lung, Cellular and
gestational age. Journal of Pediatrics 2010: 156(3): pp 388-392.
Molecular Physiology 2009: 297(6): pp L1170-L1178.
Campbell D, Barozzino T, Farrugia M, Sgro M: High-fidelity
Belik J: Riociguat, an oral soluble guanylate cyclase stimulator
simulation in neonatal resuscitation. Pediatric and Child Health
for the treatment of pulmonary hypertension. Current Opinion
2009: 14(1): pp 19-23.
in Investigational Drugs 2009: 10(9): pp 971-979.
Campoccia F, Almadhoob AR, Beck J, Slutsky AS, Dunn MS,
Bishara R, Dunn MS, Merko S, Darling P: Volume of foremilk,
Sinderby C: Neurally adjusted ventilatory assist and pressure
hindmilk, and total milk produced by mothers of very preterm
support ventilation in small species and the impact of
infants born at less than 28 weeks of gestation. Journal of
instrumental dead space. Neonatology 2009: 97: pp 279-285.
Human Lactation 2009: 25: pp 272-279.
Chambers CT, Taddio A, Uman LS, McMurtry CM, HELPinKIDS
Bismilla Z, Finan E, McNamara PJ, LeBlanc V, Jefferies A,
Team: Psychological interventions for reducing pain and
Whyte H: Failure of paediatric and neonatal trainees to meet
distress during routine childhood immunizations: a systematic
Canadian neonatal resuscitation program standards for neonatal
review. Clinical Therapeutics 2009: 31(Suppl2): pp S77-S103.
intubation. Journal of Perinatology 2010: 30(3): pp 182-187.
Chapman KP, Courtney-Martin G, Moore A, Langer JC,
Blount M, Ebling MR, Eklund M, James AG, McGregor C,
Tomlinson C, Ball RO, Pencharz P: The lysine requirement of
Percival N, Smith K, Sow D: A framework for analysis of
parenterally fed post-surgical human neonates. American
physiological data stream in intensive care environments.
Journal of Clinical Nutrition 2010: 91(4): pp 958-965.
IEEE Engineering in Biology and Medicine Magazine 2010:
Cheng SS, Forte V, Shah V: Symptomatic congenital vallecular
29(2): pp 110-118.
cyst in a neonate. Journal of Pediatrics 2009: 155: p 446.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Jillian Lewis
Ilana Magder
Patrocinio Mateo
Halima Maulidi
Adel Mohamed
Rohit Nagar
Nehad Nasef
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Sheryle Rogerson
Sameer Sadawarte
Mohit Sahni
Jesal Sheth
Abd Elazeez Shabaan
Jessie Van Dyk
Jennifer Young
Dr. Qian-shen Zhang
Dr. Lan Zhang
Dr. Meijian Zhao
Research Trainees
An Chen
Manal El Sayed
Ben Hur Johnson Mora
Xiaoying Li
Yue Zhang
Ann Man Yi
Mandy Lau
Azhar Masoud
Administrative Staff
Sonia Dos Santos
Violeta Dukic
Ana Granic
Jewel Randolph
Nithya Ravi
Choong K, Bohn D, Joffe A, Menum K, McNamara PJ, Litalien C:
Graham S, Shah PS, Von Aesch Z, Beyene J, Bayoumi A: A
Vasopressin in pediatric shock тАУ A randomized controlled trial.
systematic review of trials evaluating biomedical HIV prevention
American Journal of Respiratory and Critical Care Medicine
interventions shows that many lack power. HIV Clinical Trials
2009: 180(7): pp 632-639.
2009: 10: pp 413-431.
Committee on Fetus and Newborn, American Academy of
Grushka JR, Laberge JM, Puligandla P, Skarsgard ED, Canadian
Paediatrics: Advanced practice in neonatal nursing. Pediatrics
Pediatric Surgery Network: Effect of hospital case volume on
2009: 123: pp 1606-1607.
outcome in congenital diaphragmatic hernia: The experience of
Courtney-Martin G, Moore AM, Ball RO, Pencharz PB: The
Surgery 2009: 44(5): pp 873-876.
the Canadian Pediatric Surgery Network. Journal of Pediatric
addition of cysteine to the total sulphur amino acid requirement
as methionine does not increase erythrocytes glutathione
Honor├й JC, Kooli A, Hou X, Hamel D, Rivera JC, Hardy P,
synthesis in the TPN fed human neonate. Pediatric Research
Varma D, Jankov RP, Mancini J, Balazy M, Chemtob S:
2010: 67: pp 320-324.
Sustained hypercapnia causes cerebral microvascular
degeneration in the immature brain through induction of
Cowan KN, Puligandla PS, B├╝tter A, Skarsgard ED, Laberge JM,
nitrative stress. American Journal of Physiology: Regulatory,
and the Canadian Pediatric Surgery Network: The gastroschisis
Integrative and Comparative Physiology 2010: 298: pp
bowel score predicts outcome in gastroschisis. The Journal of
R1522-R1530.
Surgical Research 2009: 151: pp 290.
Ivanecky I, Belik J: Prenatal arginase changes and fetal
Davis PG, Schmidt B, Roberts RS, Doyle LW, Asztalos E,
oxygenation. The Open Nitric Oxide Journal 2010: 2: pp 77-82.
Haslam R, Sinha S, Tin W, for the Caffeine for Apnea of
Prematurity Trial Group: Caffeine for apnea of prematurity trial:
Jain A, Kelly E, Shah VS: Parvovirus B19 infection in pregnancy:
Benefits may vary in Subgroups. Journal of Pediatrics 2010:
Implications for childhood and outcomes. The Open Infectious
156(3): pp 382-387.
Diseases Journal 2009: 3: pp 83-93.
El-Khuffash A, McNamara PJ: Doppler ultrasound in neonatal
James AG, Ng E, Shah PS: A reference set of SNOMED terms
haemodynamics. Seminars in Fetal and Neonatal Medicine
for the structured representation of respiratory disorders of the
2010: June 18 [Epub ahead of print].
newborn infant. Studies in Health Technologies and Informatics
2009: 150: pp 243-247.
El-Naggar W, Yiu A, Mohamed A, Shah V, Manley J, McNamara P,
Taddio A: Comparison of pain responses between two different
Janssen P, Saxell L, Page L, Klein MC, Liston R, Lee SK:
methods of urine collection for diagnosis of infection in preterm
Outcomes of planned home birth with registered midwife
infants. Paediatrics 2010: 125(6): pp 1224-1229.
versus planned hospital birth with midwife or physician.
Epelman M, Daneman A, Kellenberger CJ, Aziz A, Konen O,
pp 377-83.
Canadian Medical Association Journal 2009: 181(6-7):
Moineddin R, Whyte H, Blaser S: Neonatal encephalopathy:
A prospective comparison of head US and MRI. Paediatric
Kumar A, Lakkundi A, McNamara PJ, Sehgal A: Surfactant and
Radiology 2010: April 22 [Epub ahead of print].
patent ductus arteriosus. Indian Journal of Pediatrics 2010:
77(1): pp 51-55.
130
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Kwan D, Beyene J, Shah PS: Adverse consequences of internet
McCaul C, Engelberts D, Kornecki A, McNamara PJ,
purchase of pharmacological agents or dietary supplements.
Kavanagh BP: PEEP improves survival in a rodent model of
Pharmacy Technology 2009: 25: pp 355-360.
CPR. Anesthesia and Analgesia 2009: 109(4): pp 1202-1208.
Lee SK, Canadian Neonatal Network EPIC Study Group.
McDonald SD, Han Z, Mulla S, Murphy KE, Beyene J, Ohlsson A,
Improving the quality of care for infants: A cluster randomized
on behalf of the Knowledge Synthesis Group: Preterm birth
controlled trial. Canadian Medical Association Journal 2009:
and low birth weight among in vitro fertilization singletons:
181: pp 469-476.
A systematic review and meta-analyses. European Journal of
Liu JQ, Morton J, Miedzyblocki M, Lee TF, Bigam DL, Fok TF,
146: pp 138-148.
Obstetrics and Gynecology and Reproductive Biology 2009:
Chen C, Lee SK, Davidge ST, Cheung PY: Sodium tanshinone
IIA sulfonate increased intestinal hemodynamics without
McDonald SD, Han Z, Mulla S, Murphy KE, Beyene J, Ohlsson A,
systemic circulatory changes in healthy newborn piglets.
on behalf of the Knowledge Synthesis Group: Preterm birth and
American Journal of Physiology. Heart and Circulatory
low birth weight among in vitro fertilization twins: A systematic
Physiology 2009: 297: pp H1217-H1224.
review and meta-analyses. European Journal of Obstetrics and
Gynecology & Reproductive Biology 2010: 148: pp 105-113.
Lodha A, Asztalos E, Moore A: Cytokine levels in neonatal
necrotising enterocolitis and long-term growth and
McNamara PJ, Mak W, Dunn M, Kelly E, Whyte H, Sehgal A,
development. Acta Paediatrica 2010: 99(3): pp 338-343.
McCrindle BW: Hemodynamic changes after delivery room
Magee LA, Abalos E, von Dadelszen P, Sibai B, Walkinshaw SA,
Archives of Disease in Childhood. Fetal and Neonatal Edition
for the CHIPS Study Group, Asztalos E: Control of hypertension
2010: June 7 [Epub ahead of print].
surfactant administration to very low birth weight infants.
in pregnancy. Current Hypertension Reports 2009: 11(6):
pp 429-436.
Mercier CE, Dunn MS, Ferelli KR, Howard DB, Soll RF, for the
Vermont Oxford Network ELBW Follow-up Study Group, Asztalos
Masood A, Belcastro R, Li J, Kantores C, Jankov RP, Tanswell
E: Neurodevelopmental outcomes of extremely low birth weight
AK: A peroxynitrite decomposition catalyst prevents 60%
infants from the Vermont Oxford Network: 1998-2003.
O2-mediated rat chronic neonatal lung injury. Free Radical
Neonatology 2010: 97(4): pp 329-338.
Biology & Medicine 2010: 49: pp 1182-1191.
Mills JL, Lin Y, MacNab YC, Skarsgard ED, Canadian Pediatric
Masood A, Yi M, Belcastro R, Shek S, Pan P, Kantores C,
Surgery Network: Does overnight birth influence treatment or
McNamara PJ, Kavanagh BP, Belik, Jankov RP, Tanswell AK:
outcome in congenital diaphragmatic hernia? American Journal
Therapeutic effects of hypercapnia on chronic lung injury and
of Perinatology 2010: 27(1): pp 91-95.
vascular remodeling in neonatal rats. American Journal of
Physiology: Lung, Cellular and Molecular Physiology 2009:
Nasef N, OтАЩBrien K, Wylie L, Unger S: Lessons from SARS:
297(5): pp L920-L930.
A retrospective study of outpatient care during an infectious
disease outbreak. BMC Pediatrics 2010: 10: p 51.
Massey KA, Magee LA, Dale S, Claydon J, Morris TJ, von
Dadelszen P, Liston RM, Ansermino JM, Canadian Perinatal
Nasr A, McNamara PJ, James AJ, Langer J: Is routine
Network Collaborative Group, British Columbia Perinatal Health
preoperative 2D echocardiography necessary for infants with
Program: A current landscape of provincial perinatal data
esophageal atresia, omphalocele, or anorectal malformation?
collection in Canada. Journal of Obstetrics and Gynaecology
Journal of Pediatric Surgery 2010: 45(5): pp 876-879.
Canada 2009: 31(3): pp 236-246.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 131
Nasr A, McNamara PJ, Mertens L, Levin D, James A,
Reilly BJ, M, Grasselli G, Mirabella L, Slutsky A, Dunn M,
Holtby H, Langer J: Is routine preoperative 2-dimensional
Sinderby C: Patient-ventilator interaction during neurally
echocardiography necessary for patients with esophageal
adjusted ventilatory assist in low birth weight infants.
atresia, omphalocele, or anorectal malformations? Journal
Pediatric Research 2009: 65(6): pp 663-668.
of Pediatric Surgery 2010: 45(5): pp 880-886.
Robinson JL, Davies HD, Barton M, OтАЩBrien K, Simpson K,
Ng E, Taddio A, Ohlsson A: Intravenous midazolam infusion
Asztalos E, Synnes A, Rubin E, Le Saux N, Hui C, Langley JM,
for sedation of infants in the neonatal intensive care unit
Sauve R, de Repentigny L, Kovacs L, Tan B, Richardson SE:
(Review update). Cochrane Database of Systematic Reviews
Characteristics and outcome of infants with candiduria in
2010: CD002052
neonatal intensive care: A Paediatric Investigators Collaborative
Nulman I, Sgro M, Barrera M, Chitiyat D, Cairney J, Koren G:
Infectious Ddiseases 2009: 9: p 183.
Network on Infections in Canada (PICNIC) Study. BMC
Long-term neurodevelopment of children exposed in utero to
ciclosporine after maternal renal transplant. Paediatric Drugs
2010: January 22 [Epub ahead of print].
Salmasi G, Grady R, Jones J, McDonald SD, on behalf of the
Knowledge Synthesis Group: Environmental tobacco smoke
exposure and perinatal outcomes: A systematic review and
Ohlsson A, Shah V: Intrapartum antibiotics for known maternal
meta-analyses. Acta Obstetricia Gynecologica et Scandinavica
Group B streptococcal colonization. Cochrane Database of
2010: 89: pp 423-441.
Systematic Reviews 2009: CD007467.
Seghal A, El-Naggar W, Glanc P, Asztalos E: Risk factors and
Pillai Riddell RR, Stevens BJ, McKeever P, Gibbins S,
ultrasonographic profile of posterior fossa haemorrhage in
Asztalos L, Katz J, Ahola S, Din L: Chronic pain in hospitalized
preterm infants. Journal of Paediatrics & Child Health 2009:
infants: Health professionalsтАЩ perspectives. The Journal
45(4): pp 215-218.
of Pain 2009: 10(12): pp 1217-1225.
Seghal A, Mak W, Dunn M, Kelly E, Whyte H, McCrindle B,
Proctor LK, Rushworth V, Shah PS, Keunen J, Windrim R,
McNamara PJ: Hemodynamic changes after delivery room
Ryan G, Kingdom J: Under-estimation of fetal weight in
surfactant administration to very low birth weight infants.
asymmetric preterm growth restriction by incorporation of
Archives of Disease and Child Fetal Neonatal Education 2010:
femur length. Ultrasound in Obstetrics and Gynecology 2010:
95(5): pp F345-F351.
35: pp 442-448.
Shah PS, Balkhair T, Ohlsson A, Beyene J, Scott F, Frick C,
Rafay M, deVeber GA, Cortez MA, Tan-Dy C, Al-Futaisi A,
on behalf of the Knowledge Synthesis Group on LBW/preterm
Yoon W, MacGregor D, Moore AM: Predictive value of clinical
birth: Intention to become pregnant and low birth weight and
and EEG features in the diagnosis of stroke and hypoxic
preterm birth: A systematic review. Maternal and Child Health
ischemic encephalopathy in neonates with seizures.
Journal 2009: December 9 [Epub ahead of print].
Stroke 2009: 40: pp 2402-2407.
Shah PS, Shah P, Young Tai KF: Chest compression and/or
Ray JG, Jiang D, Sgro M, Shah R, Singh G, Mamdani MM:
epinephrine at birth for preterm infants <32 weeks gestational
Thresholds for small gestational age among newborns of East
age: matched cohort study of neonatal outcomes. Journal of
Asian and South Asian ancestry. Journal of Obstetrics and
Perinatology 2009: 29: pp 693-697.
Gynaecology Canada 2009: 31(4): pp 322-330.
132
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Shah PS, Shah V, on behalf of the Knowledge Synthesis Group
Shivananda S, Kirsh J, Whyte HE, Muthallaly K, McNamara PJ:
on LBW/preterm birth: Influence of maternal birth status on
Impact of oxygen saturation targets and oxygen therapy during
subsequent low birth weight and preterm birth: A systematic
the transport of neonates with clinically suspected congenital
review. Acta Obstetricia et Gynecologica Scandinavica 2009:
heart disease. Neonatology 2010: 97(2): pp 154-162.
88: pp 1307-1318.
Shivananda S, Muthalally K, Whyte HE, Kirsh J, McNamara PJ:
Shah PS, Zao J, on behalf of the Knowledge Synthesis Group
Is oxygen safe in the transport of neonates with clinically
on LBW/preterm birth: Induced termination of pregnancy
suspected congenital heart disease? Neonatology 2009:
and low birth weight and preterm birth: A systematic review.
97(2): pp 154-162.
British Journal of Obstetrics and Gynaecology 2009: 116:
pp 1425-1442.
Shroff MM, Soares-Fernandes JP, Whyte H, Raybaud C: MR
Shah PS: Extensive cardiopulmonary resuscitation for VLBW
newborn. RadioGraphics 2010: 30(3): pp 763-780.
imaging for diagnostic evaluation of encephalopathy in the
and ELBW infants: A systematic review and meta-analysis.
Journal of Perinatology 2009: 29: pp 655-661.
Simic N, Westall C, Asztalos EV, Rovet J: Visual abilities
at 6 months in preterm infants: Impact of thyroid hormone
Shah PS: Hypothermia: a systematic review and meta-analysis
deficiency and neonatal morbidity. Thyroid 2010: 20(3):
of clinical trials. Seminars in Fetal and Neonatal Medicine
pp 309-315.
2010: March 7 [Epub ahead of print].
Simmons B, Wagner S: Assessment of continuing
Shah V, Taddio A, Rieder MJ, HELPinKIDS Team: Effectiveness
interprofessional education: Lessons learned. The Journal
and tolerability of pharmacologic and combined interventions
of Continuing Education in the Health Professions 2009:
for reducing injection pain during routine childhood
29(3): pp 168-171.
immunizations: systematic review and meta-analyses.
Clinical Therapeutics 2009: 31(Suppl 2): pp S104-S151.
Soylu H, Brandao L, Lee K-S: Efficacy of recombinant tissue
Shen Y, Dies KA, Holm IA, Bridgemohan C, Sobeih MM,
catheters in neonates. Journal of Pediatrics 2010: 156:
Caronna EB, Miller KJ, Frazier JA, Silverstein I, Picker J,
pp 197-201.
plasminogen (TPA) for restoring occluded central venous
Weissman L, Raffalli P, Jeste S, Demmer LA, Peters HK,
Brewster SJ, Kowalczyk SJ, Rosen-Sheidley B, McGowan C,
Soylu H, Jefferies A, Diambomba Y, Windrim R, Shah PS:
Duda AW 3rd, Lincoln SA, Lowe KR, Schonwald A, Robbins M,
Rupture of membranes before the age of viability and birth
Hisama F, Wolff R, Becker R, Nasir R, Urion DK, Milunsky JM,
after the age of viability: Comparison of outcomes in a matched
Rappaport L, Gusella JF, Walsh CA, Wu BL, Miller DT, Autism
cohort study. Journal of Perinatology 2010: March 11 [Epub
Consortium Clinical Genetics/DNA Diagnostics Collaboration:
ahead of print].
Clinical genetic testing for patients with autism spectrum
disorders. Pediatrics 2010: 125(4): e727-e735.
Stade B, Ali A, Bennett D, Campbell DM, Johnston M, Lens C,
Tran S, Koren G: The burden of prenatal exposure to alcohol:
Shivananda S, Kirsh J, Whyte HE, Muthallaly K, McNamara PJ:
revised measurement of cost. The Canadian Journal of Clinical
Accuracy of clinical diagnosis and decision to commence
Pharmacology 2009: 16(1): pp e91-e102.
intravenous prostaglandin E1 in neonates presenting with
hypoxemia in a transport setting. Journal of Critical Care 2010:
25(1): p 174.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 133
Stade B, Sgro M, Bailey C, Dzendoletas D, Bennett D, and
Tanswell AK: Inflammation in bronchopulmonary dysplasia.
Dowswell T: Psychological and/or educational interventions for
Canadian Respiratory Journal 2010: 17: pp e36-e37.
reducing prenatal alcohol consumption in pregnant women and
women planning pregnancy. Cochrane database of systematic
Tomlinson C, Rafii M, Ball RO, Pencharz P: The significance of
reviews 2009: 15(2): CD004228.
d-isomers in stable isotope studies in humans is dependent on
Stevens B, McGrath P, Ballantyne M, Yamada J, Dupuis A,
Clinical and Experimental 2010: 59(1): pp 14-19.
the age of the subject and the amino acid tracer. Metabolism:
Gibbins S, Franck L, Allen Finley G, Howlett A, Johnston C,
OтАЩBrien K, Ohlsson A: Influence of risk of neurological
Toporsian M, Jerkic M, Zhou Y-Q, Kabir MG, Yu LX,
impairment and procedure invasiveness on health
McIntyre BAS, Davis A, Wang YJ, Stewart DJ, Belik J, Husain M,
professionalsтАЩ management of procedural pain in neonates.
Henkelman M, Letarte M: Spontaneous adult-onset pulmonary
European Journal of Pain 2010: January 2 [Epub ahead of print].
arterial hypertension due to increased endothelial oxidative
stress in a murine model of hereditary hemorrhagic
Taddio A, Chambers CT, Halperin SA, Ipp M, Lockett D,
telangiectasia. Arteriosclerosis, Thrombosis and Vascular
Rieder MJ, Shah V, HELPinKIDS Team: Inadequate pain
Biology 2010: 30: pp 509-517.
management during routine childhood immunizations: The
nerve of it. Clinical Therapeutics 2009: 31(Suppl 2): pp S12-S67.
Turner D, Zlotkin SH, Shah PS, Griffiths AM: Omega-3 fatty
acids (fish oil) for maintenance of remission in inflammatory
Taddio A, Ilersich AL, Ipp M, Kikuta A, Shah V; HELPinKIDS
bowel disease: a systematic review and meta-analyses.
Team: Physical interventions and injection techniques for
Inflammatory Bowel Diseases 2010: June 17 [Epub ahead
reducing injection pain during routine childhood. Clinical
of print].
Therapeutics 2009: 31(Suppl 2): S48-S76.
Unger S, Salem S, Wylie L, Shah V: Newborn frontal horn cysts:
Taddio A, Pulleyblank R, Stephens D, McNair C, Shah V:
cause for concern? Journal of Perinatology 2010: pp 1-6
Canadian neonatologists practices regarding opioid use in
ventilated and spontaneously-breathing infants undergoing
Unger S, Wylie L, Fallah S, Heinrich L, OтАЩBrien K: Motivated by
medical procedures. The Clinical Journal of Pain 2010: 26:
money? The impact of financial incentive for the research team
pp 422-428.
on study recruitment. IRB: Ethics and Human Research 2010:
32: pp 16-19.
Taddio A, Crosdale B, Hogan ME, El Sayed MF, Lee KS,
Moore AM, Shah V: Safety of morphine in nonintubated
von Dadelszen P, Menzies JM, Payne B, Magee LA, and PIERS
infants in the neonatal intensive care unit. The Clinical
(Pre-eclampsia Integrated Estimate of RiSk) Study Group:
Journal of Pain 2009: 25: pp 418-422.
Predicting adverse outcomes in women with severe preeclampsia. Seminars in Perinatology 2009: 33(3): pp 152-157.
Tan DH, Asztalos E, Douglas D, Read S, Bitnun A:
Congenital transmission of human immunodeficiency virus,
Wieczorek PM, Guest S, Balki M, Shah V, Carvalho JCA: Breast
cytomegalovirus, and toxoplasmosis in a premature infant.
feeding success rate after vaginal delivery can be high despite
Pediatric Infectious Disease Journal 2009: 28(12):
the use of epidural fentanyl: An observational cohort study.
pp 1129-1131.
International Journal of Obstetric Anesthesia 2010: 19:
pp 273-277.
134
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Williams C: Shared decision making in the NICU: The virtuous
Books and Book Chapters
triad. Publication at the Royal College of Physicians and
Hellmann J: Commentary: Attitudes of neonatologists toward
Surgeons website for the JKR Wightman Award for Scholarship
delivery room management of confirmed trisomy 18: Potential
in Ethics, July 2009 http://rcpsc.medical.org/awards/
factors influencing a changing dynamic. In: 2009 Year Book of
manuscripts/Virtuous_Triad.pdf.
Neonatal and Perinatal Medicine (Fanaroff AA, Benitz W, Neu J,
Papile L-A, eds.). Mosby, St. Louis, MO, 2009.
Yinon Y MD, Visser J MD, Kelly EN MB, Windrim R MD,
Amsalem H MD, Seaward PG MB, Ryan G MB: Early intra-
Hellmann J: Commentary: Message framing and perinatal
uterine transfusions in severe red blood cell alloimmunization.
decisions. In: 2009 Year Book of Neonatal and Perinatal
Ultrasound in Obstetrics and Gynecology 2010: May 27
Medicine (Fanaroff AA, Benitz W, Neu J, Papile L-A, eds).
[Epub ahead of print].
Mosby, St. Louis, MO, 2009.
Yinon Y, Grisaru-Granovsky S, Chadda V, Windrim R, Seaward GR,
Hellmann J: Commentary: Values parents apply to decision-
Kelly EN, Beresovska O, Ryan G: Perinatal outcome following
making regarding delivery room resuscitation for high-risk
fetal chest shunt insertion for pleural effusions. Ultrasound in
newborns. In: 2009 Year Book of Neonatal and Perinatal
Obstetrics and Gynecology 2010: 36: pp 58тАУ64.
Medicine (Fanaroff AA, Benitz W, Neu J, Papile L-A, eds.).
Mosby, St. Louis, MO, 2009.
Yinon Y, Kingdom JC, Proctor LK, Kelly EN, Salle JL, Wherrett D,
Keating S, Nevo O, Chitayat D: Hypospadias in males with
McNamara PJ: Prematurity and cardiac disease. In: Textbook
intrauterine growth restriction due to placental insufficiency:
of Pediatric Cardiology 3rd Edition (Anderson RH, Baker EJ,
The placental role in the embryogenesis of male external
Redington A, Rigby ML, Penny D, eds.). Churchill Livingston
genitalia. American Journal of Medical Genetics 2010:
Publishing, New York, 2009.
152A(1): pp 75-83.
Ohlsson A, Shah P: Determinants of Low Birth Weight and
Yudin M, Salaripar M, Sgro M: Pregnant womenтАЩs knowledge of
Preterm Births: A Synopsis of Evidence. Institute of Health
influenza and the use and safety of the influenza vaccine during
Economics, Edmonton, Alberta, 2009.
pregnancy. Journal of Obstetrics and Gynaecology Canada
2009: 31(2): pp 120-125.
Percival J, Catley C, McGregor C, James A: A design for
modelling the impact of information and communication
Yudin MH, Salaripour M, Sgro MD: Impact of patient education
technologies on patient journeys in neonatal intensive care
on knowledge of influenza and vaccine recommendations
units. In: Intelligent Patient Management: Studies in
among pregnant women. Journal of Obstetrics and Gynaecology
Computational Intelligence, Volume 189 (McClean S, Millard P,
Canada 2009: 32(3): pp 232-237.
El-Darzi, Nugent C, eds.). Springer, Berlin/Heidelberg. 2009.
Ziino AJA, Ivanovska J, Belcastro R, Kantores C, Xu EZ, Lau M,
Shah V: Pain in the neonate. In: Recent Advances in
McNamara PJ, Tanswell AK, Jankov RP: Effects of Rho-kinase
Neonatology (Sharma N, Jain S, Verma VK, eds.).
inhibition on pulmonary hypertension, growth and abnormal
RajNeoCoN, India, 2009.
lung structure in neonatal rats chronically exposed to hypoxia.
Pediatric Research 2010: 67(2): pp 177-182.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 135
Tanswell AK, Padela S, Jankov RP: Altered growth factor
An innovative multi-faceted approach to implementation of
signaling in the pathogenesis of BPD. In: Bronchopulmonary
recommendations for management of infants at increased risk
Dysplasia (Abman SH, ed.). Informa Healthcare, New York, 2009.
for sepsis for inter-professional health care team. Shah V.
Ministry of Health and Long-Term Care Innovation Fund
Whyte H: Neonatal transport. In: Canadian Edition of Nancy
($41,850 2009)
CarolineтАЩs Emergency Care in the Streets, Canadian Edition,
6th Edition (MacDonald RD, Burgess RJ, eds.). Jones & Bartlett
Learning, Sudbury, MA, 2009.
Antepartum care of high risk pregnancy team. Janssen P, Lee S.
Michael Smith Foundation for Health Research ($213,090
2008-2011)
Funding
A CIPP framework for implementation and evaluation of a
Assessment and evaluation of a pilot interprofessional OSCE
faculty development program for neonatal-perinatal medicine.
(iOSCE). Simmons B, Reeves S, Wagner S. Undergraduate
Jefferies A, Finan E, Lee KS, Simmons B. Continuing Education
Medical Education Curriculum Renewal Fund тАУ University of
Research and Development Grant, University of Toronto
Toronto/The University of Toronto Office of Interprofessional
($4,900 2010-2011)
Education ($19,141 2009)
A comparison of debriefing methods following simulated
Assessment and evaluation of a pilot interprofessional OSCE
neonatal resuscitation. Williams C. NRP Research Grant
(iOSCE). Simmons B, Reeves S, Wagner S. Matching Funds
($16,180 2010)
Medical Council of Canada/The University of Toronto Office
of Interprofessional Education ($10,000 2009)
A critical appraisal of resuscitation practices in the NICU.
Gibbins S, Dunn M, Asztalos E, Schurr P, Chow J, Kiss A.
Birth under 29 weeks: Improving outcomes for mothers and
PBR Award Sunnybrook Health Sciences Centre ($12,358
babies. Liston R, Magee L, Allen VM, Ansermino JM, Barrett J,
2010-2011)
Lee SK, Piedboeuf B, Smith GN, Von Dadelszen P, Walker MC.
Canadian Institutes of Health Research (330,860 2005-2009)
A multi-faceted approach to the implementation of
recommendations for management of infants at increased risk
Calgary Impact of (ACoRN) acute care of at risk newborn
for sepsis for the interprofessional health care team. Shah V,
education program in rural China. Singhal N, Lee S. Canadian
Jefferies A. Academic Health Sciences Alternate Funding Plan
Institutes of Health Research ($90,000 2008-2010)
Phase III Innovation Fund ($39,613 2009-2010)
Canadian Child Health Clinician Scientist Program. Rosenblum
A national role-based survey investigating the use of
N, Lee S. Canadian Institutes of Health Research
information technology in canadian neonatal intensive care
($4,500,000 2002-2015)
units. Percival JC, McGregor C, Catley C, James A. Canadian
Patient Safety Institute ($20,000 2009-2010)
Canadian Pediatric Surgery Network Extension (CAPSNet-X).
Airway modulation of pulmonary vascular tone during
($10,000 2009-2010)
Puligandla P, Lee S. Canadian Institutes of Health Research
development and following pulmonary hypertension. Belik J.
Canadian Institutes of Health Research ($110,108/year
CARESS: Canadian RSV Evaluation Study Of Synagis┬о. Abbott
2004-2009)
Laboratories Ltd. An investigator-initiated study. Mitchell I,
Paes B, Allen U, James AG. Abbott Laboratories Ltd.
($120 per patient enrolled 2007-2009)
136
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
CIHR team in childrenтАЩs pain. Stevens B, Lee S. Canadian
DOMINO donor milk for improved neurodevelopmental
Institutes of Health Research ($4,054,611 2006-2011)
outcomes. Unger S. Canadian Institutes of Health Research
($920,270 2010-2015)
CIHR Team in Maternal Infant Care тАУ Translating knowledge
into improved care. Lee SK, Armson BA, Aziz K, Baker GR,
Donor human milk versus preterm formula as a substitute for
Barrington K, Dendukur N, El-Hajj MO, Haywood RS,
motherтАЩs own milk for feeding very low birth weight infants.
Joseph KJ, Liston RM, Magee LA, Ohlsson A, Saigal S,
OтАЩConnor D, Asztalos E. Canadian Institutes of Health
Sauve RS, Shaw NT, Skarsgard ED, Steven BJ, for the Canadian
Research ($920,271 2010-2015)
Neonatal Network. Canadian Institutes of Health Research
($4,902,460 2008-2013)
Donor human milk versus preterm formula as a substitute for
CIHR Team in Maternal-Infant Care. Lee S. Canadian Institutes
Campbell D. Canadian Institutes of Health Research
of Health Research ($5,640,990 2008-2013)
($184,000 2009)
CIHR Team in Pediatric Emergency Medicine. Klassen T,
Early external cephalic version-2 trial - renewal. Hutton EK,
Lee S. Canadian Institutes of Health Research ($3,845,904
Willan AR, Hannah ME, Gafni A, Ohlsson A, Barrett J, Ross SJ,
mothersтАЩ own milk for feeding very low birth weight infants.
2006-2011)
Windrim R, Delisle MF, Carson GD, Dunn MS, Pollard JK,
Natale R. Canadian Institutes of Health Research ($2,853,717
Control of Hypertension in Pregnancy Study (CHIPS). Magee L,
2003-2009)
Asztalos E, Ross S, Hutton E, Murphy K, Logan S, Moutquin JM,
Rey E, von Dadelszen P, Gruslin A, Helewa M, Lee S, Gafni A,
Effect of folic acid supplementation in pregnancy on
Singer J. Canadian Institutes of Health Research ($3,743,575
preeclampsia. Wen S, Lee S. Canadian Institutes of Health
2008-2014)
Research ($6,525,375 2009-2014)
Creating bone and joint health from the bedside to the bench
Efficacy and safety of methyxanthines in very low birth weight
and back. Frank C, Lee S. Alberta Heritage Foundation for
infants. Schmidt B, Asztalos E, Ohlsson A. Canadian Institutes
Medical Research ($5,000,000 2008-2013)
of Health Research ($2,038,135 2010-2015)
Death in Canadian neonatal intensive care units (NICUs):
Efficacy and safety of targeting lower arterial saturations to
Exploring the ethical determinants. Hellmann J, Shah P, Lee SK.
reduce oxygen toxicity and oxidative stress in very preterm
Canadian Institutes of Health Research ($124,998 2008-2010)
infants: The Canadian oxygen trial (COT). Schmidt B, Asztalos
E, Roberts R, Whyte R, Solimano A. Canadian Institutes of
Delayed umbilical cord clamping in preterm infants:
Health Research ($3,884,860 2006-2011)
A randomized controlled trial. Kelly C, Kellie M, Whittle W,
Windrim R, Shah PS. Mount Sinai Hospital, Department
Endothelial eNOS uncoupling and role of BMP-9 in the
of Obstetrics and Gynecology Research Fund ($4,000
regulation of pulmonary vascular tone during development and
2008-2010)
following pulmonary hypertension. Belik J, Letarte M, Toporsian
Design and evaluation of an Interprofessional OSCE
2007-2009)
M, Jerkic M. Heart and Stroke Foundation ($86,906/year
(Objective Structured Clinical Examination) Development (IpOD)
simulation tool. Simmons B, Reeves S, Wagner SJ. Network of
EPIQ-II project. James A. Canadian Institutes of Health
Excellence for Simulation in Clinical Teaching and Learning
Research ($42,215 2009-2011)
($49,200 2009-2010)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 137
Establishment of a Canadian-based international research
Hypercapnia as therapy for neonatal pulmonary hypertension.
network to improve quality of life, communication, and
Jankov RP. Canadian Institutes of Health Research ($579,880
economic outcomes in head and neck cancer survivors.
2009-2014)
Rieger J, Lee S. Canadian Institutes of Health Research
($100,000 2010-2011)
Hypoglycemia and neuroplasticity in the neonatal period.
Shroff MM, Moore AM, Whyte HEA, Taylor MJ. Translational
Evaluation of case-based Interprofessional Education (IPE)
Research Grant, Department of Medical Imaging, University
sessions: Development and implementation. Wagner S, Reeves
of Toronto ($35,000/year 2008-2010)
S, Simmons B. Undergraduate Medical Education Curriculum
Renewal Fund тАУ University of Toronto/The University of
Impact of ACORN newborn education program in rural China.
Toronto Office of Interprofessional Education ($13,951 2009)
Du L, Singhal N, McMillan DD, Aziz K, Lee SK. Canadian
Institutes of Health Research ($180,000 2008-2011)
Fluconozole prophylaxis for the prevention of candidiasis in
Infants <750 grams birth weight. Benjamin D, Asztalos E,
Implementation of a wireless positive patient identification
Smith P, Wade K. National Institute of Child Health and
system for the prevention of breast milk errors in the NICU.
Human Development ($2,793,089 2008-2013)
OтАЩBrien K, Unger S. Ministry of Health and Long-Term Care
Innovation Funds ($56,807 2009-2010)
Genome-environment interactions in type i diabetes. Danska J,
MacPherson A, Moore AM. Genome Canada ($94,127
2005-2009)
Improving safety in the insertion and care of percutaneously
inserted central catheters (PICCs) and umbilical catheters
(UCs) in 3 neonatal intensive care units (NICUs). Lee KS,
Group in Lung Development. Tanswell AK, Belik J, Chan A,
Dunn M, Jefferies A, Gibbins S, Doctor S. Canadian Medical
OтАЩBrodovich H, Post M, Rotin D, Cutz E, Hu J, Kavanagh B,
Protective Association Collaborative Research Grant
Otulakowski G, Yeger H. Canadian Institutes of Health
($49,750 2009-2011)
Research ($275,539 2004-2009)
Inhibition of physiological apoptosis as a major component of
Harmonizing evidence with consumer expectations,
chronic neonatal lung injury. Tanswell AK, Jankov RP. Canadian
interdisciplinary knowledge and organizational matrixes to
Institutes of Health Research ($430,045 2007-2012)
attain optimal mode of birth patterns. Andruschak J, Lee S.
Canadian Institute of Health Research ($195,346 2008-2010)
Initiative for translational hypertension research. Branko B,
Lee SK. University of Alberta ($300,000 2008-2011)
Head and Neck Research Network: A multidisciplinary
Canadian-based international team for improving
Innovation Fund. Sgro M. Innovation Fund, Physicians Services
communication and quality of life in head and neck cancer
Association, St. MichaelтАЩs Hospital ($13,000 2009)
survivors. Rieger J, Lee S. Canadian Institutes of Health
Research ($4,923 2009-2010)
IP-COMPASS: Interprofessional Collaboration Organization
Measurement & Performance Assessment. Oandasan I,
Health Law, Ethics and Policy Training Program. Flood C,
Lowe M, Parker K, Pauze E, Simmons B, Sinclair L, Wagner SJ.
Lee S. Canadian Institutes of Health Research ($3,412,500
Interprofessional Care/Education Fund тАУ Health Force Ontario
2002-2015)
($580,000 2008-2009)
138
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Keeping track of the patient in a resource-limited setting: pilot
Multiple courses of antenatal corticosteroids for preterm birth.
implementation of an electronic health record in Tanzania.
Murphy K, Lee S. Canadian Institutes of Health Research
Grimm N, Lee S. Canadian Institutes of Health Research
($7,980,470 2000-2010)
($53,167 2008-2010).
Nasal ventilation in premature infants. Kirpalani H, Chiu A,
Knowledge Translation Supplement. Shah V. Canadian
Lemyre B, Millar D, Roberts R, Vaillancourt K, Alvaro R,
Institutes of Health Research Meetings, Planning and
Connelly R, Howlett A, McNamara P, Peliowski A, Solimano A,
Dissemination Grant ($38,788 2009)
Shah P, Aziz K, Zupancic J, Meade M. Canadian Institute of
Health Research ($2,233,100 2007-2010)
Knowledge Translation: A pre-licensure interprofessional
clinical experience for health care student. Hunter J,
Neuroimaging and patent ductus arteriosus ligation. Taylor M,
Campbell F, Stinson J, McGillion M, Simmons B, Cameron A,
Sledge J, McNamara PJ. Natural Sciences and Engineering
Sinclair L, Lowe M, Wagner S. Pfizer Canada ($50,000, 2009)
Research Council of Canada ($384,734 2008-2012)
Low vs high fidelity simulation in neonatal resuscitation training.
Neuroimaging measures of brain function in preterm neonates.
Finan E, Bismilla Z, Whyte HE, McNamara P, LeBlanc V.
Taylor MJ, Sled JG, McNamara P, Whyte HEA, Moore AM,
Paediatric Consultants Grant ($5,000 2008-2009).
Donner EJ, Shroff MM. Collaborative Health Research
Program ($361,860 2008-2011)
Maternal-Infant Care (MICare) Research Centre. Lee S.
Ministry of Health and Long-Term Care ($15,000,000
Novel therapeutic interventions for bronchopulmonary
2009-2013)
dysplasia: Targeting oxidants and growth factors in the
newborn rat lung. Jankov RP. Canada Foundation for
MiTy Trial (Metform in Women with Type 2 Diabetes in
Innovation New Opportunities Fund/Ontario Research
Pregnancy Trial). Feig D, Lee S. Canadian Institutes of
Fund ($297,340 2004-2009)
Health Research ($1,735,119 2010-2011)
Observational study on the effects of enteral feeding and
Multicentre randomized trial of HeLP (heat loss prevention)
feeding methods on respiratory pattern as assessed by
in the delivery room. Vohra S, Reilly MC, Dunn M, Vincer M,
diaphragm electrical activity (EAdi) in very low birth weight
Wiebe N, Zayack D, Wimmer J. Canadian Institutes for Health
(VLBW) preterm infants. Ng E, Schurr P, Reilly M, Dunn M,
Research ($640,465 2004-2008)
Beck J. Physician Services Incorporated Foundation
($26,000 2008-2009)
Multiple courses of antenatal corticosteroids for preterm
birth (MACS). Murphy K, Asztalos E. Canadian Institute
Oxidative stress and neonatal pulmonary vascular resistance
of Health Research ($2,943,583; 2006-2010)
control. Belik J. Canadian Institutes of Health Research
($597,193 2009-2014)
Multiple courses of antenatal corticosteroids for preterm
birth study: A 5-year follow-up (MACS-5). Asztalos E, Gafni A,
Pain in Infants at risk for Neurological Impairment: A program
Hannah M, Murphy K, Ohlsson A, Ross S, Saigal S, Willan A,
of research: Phase3. (PINI 3). Stevens B, Gibbins S, McGrath P,
Matthews S, Rovet J, Lee S, Amankwah K, Kelly EN, Lee SK,
Johnston C, Asztalos E, OтАЩBrien K, Howlett A, McNamara P,
Delisle M-F, Guselle P, Sananes R. Canadian Institutes of
Pillai Riddell R. Canadian Institutes of Health Research
Health Research ($3,585,161; 2005-2012)
($851,050 2008-2012)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 139
Pediatric Academic Societies (PAS) Annual Meeting. Sgro M.
Role of reactive oxygen/nitrogen species in normal and
Mead Johnson Nutritionals Canada ($2,600 2010)
aberrant postnatal lung growth. Tanswell AK. Canadian
Institutes of Health Research ($708,400; 2004-2009)
Pediatric Perinatal Surgery Network (CAPSNET). Skarsgard E,
Lee SK. Canadian Institutes of Health Research ($246,500
Role of Rho-kinase in hypoxia-mediated pulmonary
2004-2009)
hypertension. Jankov RP. DeanтАЩs Fund New Staff Grants
Program, Faculty of Medicine, University of Toronto
PIERS (Pre-eclampsia Integrated Estimate of RiSK Mothers):
($10,000; 2005-2009)
Validation across conditions and clinical settings.
Von Dadelszen P, Lee S. Canadian Institutes of Health
Safety and efficacy of methylxanthines in the very low birth
Research ($774,496 2007-2010)
weight infant: Effect on sleep on the school age child.
Marcus C, Asztalos E. National Heart, Lung and Blood
Predicting neurobehaviorial outcome in preterm neonates.
Institute ($267,567/year 1 2009-2013)
Taylor M, Whyte HE, Moore A, Shroff M, Rayboud C, Donner E,
Frisk V. Canadian Institute of Health Research ($929,910;
Simulation in neonatal resuscitation. Campbell D. Innovation
2007-2012)
Fund, Physicians Services Association, St. MichaelтАЩs Hospital
($12,000 2009)
Preterm birth and healthy outcomes. Olson D, Lee S. Alberta
Heritage Foundation for Medical Research ($5,000,000
Steroids in immune mediated Congenital Complete
2008-2013)
Atrio-Ventricular Heart Block (CAVB): Do they affect brain
development? Kelly EN. PhysiciansтАЩ Services Incorporated
Randomized study of vasopressin vs epinephrine in a neonatal
Foundation ($43,900 2006-2009)
model of asphyxial cardiac arrest. McNamara PJ. American
Academy of Pediatrics ($28,940 2007-09)
Survey of mode of delivery and maternal and perinatal
outcomes in Canada. Lee S, Armson A, Allen V, Andruschuk J,
Regulation of normal and oxygen-mediated aberrant postnatal
Attenborough R, Bottomley J, DaSilva O, Frick C, Heaman M,
lung growth by growth factors. Tanswell AK. Canadian
Murphy P, Pasquier J-C, Bujold E, Crane J, Dumont A, Janssen P,
Institutes of Health Research ($799,686 2005-2010)
Klein M, Liu S, Moutquin J-M, OтАЩBrien B, Ohlsson A, Platt R,
Sauve R, von Dadelszen P, Walker M. Canadian Institutes of
Resuscitation competencies in inter-professional education
Health Research/World Health Organization ($250,000
(ReCIPE). Simmons B, Reeves S, Deland M. Neonatal
2007-2009)
Resuscitation Program Research Grant тАУ Canadian
Paediatric Society ($17,590 2009-2010)
Sustainability grant for IPE development at the University of
Toronto Office of Interprofessional Education. Oandasan I,
Rho-kinase inhibitor as therapy for chronic neonatal
Wagner S, Lowe M, Sinclair L, Tassone M, Simmons B,
pulmonary hypertension. Jankov RP, McNamara PJ. Canadian
Parker K. Ontario Ministry of Training for Colleges and
Institutes of Health Research ($323,592 2007-2010)
Universities ($150,000 2009)
Role of reactive oxygen/nitrogen species in normal and
Systematic reviews of determinants and effectiveness of
aberrant postnatal lung growth. Tanswell AK. Canadian
primary preventive interventions for low birth weight, and
Institutes of Health Research ($557,560; 2010-2015)
preterm birth. Shah P. Canadian Institutes of Health Research
тАУ Knowledge Synthesis/ Translation ($100,000 2008-2009).
140
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
The Canadian Pediatric Surgery Network (CAPSNET):
The MiTy Trial (Metformin in women with type 2 diabetes in
Establishing best practices for gastroschisis and congenital
pregnancy). Feig D, Asztalos E. Canadian Institutes of Health
diaphragmatic hernia. Bouchard S, Lee S. Canadian Institutes
Research ($1,735,119 2010-2015)
of Health Research ($100,000 2010-2011)
The Twin Birth Study: A multicentre randomized controlled trial
The CHIPS Trial (Control of Hypertension in Pregnancy Study).
comparing planned caesarean section with planned vaginal
Magee L, Lee S. Canadian Institutes of Health Research
birth for twins at 32-38 weeks gestation. Barrett J, Hannah M,
($4,263,450 2008-2014)
Willan A, Ross S, Hutton E, Allen A, Joseph KS, Armson A,
Farrell S, Ohlsson A, Asztalos E, Gafni A, Okun N, Leduc L.
The developing lung: Cellular and molecular physiology.
Canadian Institutes of Health Research ($8,608,045
Tanswell AK. Canadian Institutes of Health Research
2003-2011)
($252,476/year 2004-2009)
The WomenтАЩs Auxiliary Chair in Neonatology. Lee S.
The effect of remote ischemic preconditioning on clinical
The Hospital for Sick Children ($350,000 2009-2013)
and genomic responses to open heart surgery in children.
Redington A, McCrindle B, Holtby H, Schwartz S, Van Arsdell G,
Translating Research on Pain in Children (TROPIC) study.
Coles J, Ly L, Scherer S. Heart and Stroke Foundation of
Stevens B, Lee S. Canadian Institutes of Health Research
Ontario ($570,339 2009-2012)
($1,379,952 2008-2012)
The initiative for translational hypertension research: Tackling
Utility of modern ultrasound in the evaluation of cerebral
hypertension-related health management through knowledge
venous sinuses in neonates. Miller E, Shroff M, Moore AM.
translation, system re-design & direct translation of bench
Physicians Services Incorporated Foundation ($35,500
research to practice. Bramm B, Lee S. University of Alberta
2007-2009)
($300,000 2008-2011)
Withdrawal of artificial hydration & nutrition in newborn infants:
The interprofessional OSCE development simulation tool (part
Determining neonatal nursesтАЩ perspectives on the ethical &
I). Simmons B, Reeves S, Wagner S. Network of Excellence in
practical issues in this practice. Hellmann J, Ives-Baine L,
Simulation for Clinical Teaching and Learning/The University
Golec L, Lindsay G, Lee KS, Stephens D, Hetherington R.
of Toronto Office of Interprofessional Education ($49,200 2009)
Paediatrics Consultants Grant ($10,000 2008-2009)
The interprofessional OSCE development simulation tool (part
World Health Organization Global Survey for Maternal
II). Simmons B, Reeves S, Wagner S. Educational development
and Perinatal Outcomes in Canada. Lee SK, Armson A.
fund тАУ University of Toronto/The University of Toronto Office
World Health Organization ($500,000 2007-2009).
of Interprofessional Education ($16,827 2009)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 141
Division Head
Dr. Denis F. Geary
Full-Time
Dr. Elizabeth A. Harvey
Dr. Diane H├йbert
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Valerie Langlois
Christoph Licht
Rulan Parekh
Tino D. Piscione
Lisa A. Robinson
Norman D. Rosenblum
Part-Time
Dr. Rachel Pearl
Dr. Seetha Radhakrishnan
Dr. Lindsay Teskey
Adjunct
Dr. Leo Levin
Honorary
Dr. Gerald S. Arbus
Clinical Fellows
Dr. Badria Al-Ghaithi
Dr. Entesar Alhammadi
Dr. Naifain Al Kalbani
Dr. Reham Al-Mardini
Dr. Jamila Al-Matrafi
Dr. Turki Al Shareef
Division of Nephrology
Divisional Overview
Robinson LA: CFI LeaderтАЩs Opportunity Fund, University of
2009-2010 was another successful year for the Division of
Toronto, 2010.
Nephrology. The complexity of care provided and the number
of patients treated continue to increase. The Nephrology
Rosenblum ND: Maureen Andrew Mentor Award, Society for
Fellowship Training program, which provides a unique
Pediatric Research, 2010.
combination of comprehensive clinical training and scientific
exposure, continues to attract trainees from across the world.
Rosenblum ND: Paediatric Academic Leadership-Clinical
Investigator Award, Paediatric Chairs of Canada, 2009.
The research profile of the Division continues to grow, as
demonstrated by the number of successful grant applications
Publications
and the high quality of the journals in which their work is
Allen U, Barton B, Beyene J, Hu P, Khodai-Booran N,
published. With the recent addition of Dr. Rulan Parekh,
H├йbert D, Dipchand A, Ng V, Solomon M, Grant D, Fecteau A,
the Division is now poised to lead in both clinical and
Ngan B, Read S, Zielenska M, Weitzman S: Gene expression
epidemiological research and in basic scientific discovery.
using microarrays in transplant recipients at risk of EBV
In 2009-2010, the expertise in clinical care, education and
proof of concept. Pediatric Transplantation 2009: 13:
research of members of the Nephrology Division was recognized
pp 990-998.
lymphoproliferation after organ transplantation: Preliminary
by major awards at the local, national and international level.
The coming year will see exciting new changes as Dr. Lisa
Robinson assumes the role of Division Head.
Anthony SJ, H├йbert D, Todd L, Korus M, Langlois V, Pool R,
Robinson LA, Williams A, Pollock-BarZiv SM: Child and parental
perspectives of multidimensional quality of life outcomes
Honours and Awards
after kidney transplantation. Pediatric Transplantation 2010:
Geary DF: Claus Wirsig Humanitarian Award, The Hospital for
14: pp 249-256.
Sick Children, June 2010.
Atkinson MA, Neu AM, Oberai P, Fivush BA, Parekh RS:
Licht C: Appointed Member of the European DEAP-HUS Study
Predictors and consequences of higher estimated glomerular
Group, 2009.
filtration rate at dialysis initiation in children. Pediatric
Nephrology 2010: February 27 [Epub ahead of print]
Licht C: Appointed Member of the Safety Board of the
Barton M, Wasfy S, Dipchand AI, H├йbert D, Ng V, Solomon M,
European Treatment Trial for Alport Syndrome, 2010.
Fecteau A, Stephen D, Allen U: Seven-valent pneumococcal
Licht C: Norman Siegel Research Scholar Award, American
conjugate vaccine in pediatric solid organ transplant recipients:
Society of Nephrology, 2009.
A prospective study of safety and immunogenicity. The
Pediatric Infectious Disease Journal 2009: 28: pp 688-692.
Parekh RS: Inducted into the American Society of Clinical
Bash LD, Coresh J, K├╢ttgen A, Parekh RS, Fulop T, Wang Y,
Investigation, 2009.
Astor BC: Defining chronic kidney disease in the research
setting: The Atherosclerosis Risk in Communities (ARIC)
Robinson LA: Canada Research Chair Tier 2, 2010.
study. American Journal of Epidemiology, American Journal
of Epidemiology 2009: June 17 [Epub ahead of print].
Robinson LA: 2010 Black Business and Professional
Association (BBPA) Harry Jerome Health Sciences Award, 2010.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Swasti Chaturvedi
Siew Le Chong
Perry Lau
Andrew Lunn
Khalid Malik
Konggrapun Srisuwan
Post-Doctoral Fellows
Dr. Jason Cain
Dr. Lijun Chi
Clinical Research
Associates
Michelle Frieling
Jun Chuan Teh
Administrative Staff
Dana Debernyj
Juliet Rodrigo
Bernard Singh
Marisa Tuzi
Andrea Verdugo
Tania Viseu
Brady TM, Solomon BS, Neu AM, Siberry GK, Parekh RS:
Geary DF, Hodson EM, Craig JC: Interventions for bone disease
Patient, provider and clinic level predictors of unrecognized
in children with chronic kidney disease. Cochrane Database of
elevated blood pressure in children. Pediatrics 2010:125(6):
Systemic Reviews 2010: Issue 1: CD008327.
pp e1286-e1293.
Hiraki LT, Benseler SM, Tyrrell ON, Harvey EA, H├йbert D,
Cain JE, Di Giovanni V, Smeeton J, Rosenblum ND: Genetics of
Silverman ED: Ethnic differences in pediatric systemic lupus
renal hypoplasia: Insights into the mechanisms controlling
erythematosus. Journal of Rheumatology 2009: 36 (11):
nephron endowment. Pediatric Research 2010: 68: pp 91-98.
pp 2539-2546.
Cain JE, Islam E, Haxho F, Chen L, Bridgewater D,
Hothi DK, Harvey E, Goia CM, Geary DF: The value of
Nieuwenhuis E, Hui C-C, Rosenblum ND: GLI3 repressor
sequential dialysis, mannitol and midodrine in managing
controls nephron number via regulation of Wnt11 and Ret
children prone to dialysis failure. Pediatric Nephrology 2009:
in Ureteric Tip Cells. PLoS ONE 2009: 4(10): p e7313.
24(8): pp 1587-1591.
Chaturvedi S, Licht C, Langlois V: Hemolytic uremic syndrome
Huang Y-W, Su P, Guang YL, Crow MR, Chaukos D,
caused by Bordetella pertussis infection. Pediatric Nephrology
Yan H, Robinson LA: Constitutive endocytosis of the
2010: 25: pp 1361-1364.
chemokine, CX3CL1, prevents its degradation by cell
surface metalloproteases. Journal of Biological Chemistry
Choi N, Pluthero FG, Licht C: Intracellular localization and
2009: 284: pp 29644-29653.
release of platelet vascular endothelial growth factor. Journal
of Undergraduate Life Studies 2009: 3(1): pp 40-43.
Hugle B, Solomon M, Harvey EA, James A, Bridge M,
Bell-Peter A, Benseler S: Pneumocystis jirovecii pneumonia in
Chu AY, Parekh RS, Astor BC, Coresh J, Berthier-Schaad Y,
a child with WegenerтАЩs Granulomatosis treated with rituximab.
Smith MW, Shuldiner AR, Kao WH: Association of APOE
Arthritis & Rheumatology 2010: June 25 [Epub ahead of print]
polymorphism with chronic kidney disease in a nationally
representative sample: A Third National Health and Nutrition
Hurdowar A, Urmson L, Bohn D, Geary DF, Laxer R, Stevens P:
Examination Survey (NHANES III) Genetic Study. BMC Medical
Compliance with a paediatric clinical practice guideline for
Genetics 2009: 10: p 108.
intravenous fluid and electrolyte administration. Healthcare
Quarterly 2009: 12: pp 129-134.
De S, Waters AM, Segal AO, Trautmann A, Harvey EA, Licht C:
Severe atypical HUS caused by CFH S1191L тАУ Case
Kanbur N, Pinhas L, Lorenzo A, Farhat W, Licht C, Katzman DK:
presentation and review of treatment options. Pediatric
Nocturnal enuresis in adolescents with anorexia nervosa:
Nephrology 2010: 25 (1): pp 97-104.
Prevalence, potential causes, and pathophysiology.
International Journal of Eating Disorders 2010: March 30
El-Hout Y, Licht C, Pippi Salle JL, Ngan BY, Bagli DJ, Lorenzo AJ,
[Epub ahead of print].
Farhat WA: Hypertension in children with poorly functioning
unilateral kidneys: Predictors of resolution after nephrectomy.
Knoll GA, Blydt-Hansen TD, Campbell P, Cantarovich M, Cole E,
BJU International 2010: April 15 [Epub ahead of print].
Fairhead T, Gill JS, Gourishankar S, H├йbert D, Hodsman A,
Estrella MM, Astor BC, K├╢ttgen A, Selvin E, Coresh J,
Canadian Society of Transplantation and Canadian Society of
House AA, Humar A, Karpinski M, Kim SJ, Mainra R, Prasad GVR:
Parekh RS: Prevalence of kidney disease in anemia differs
Nephrology commentary on the 2009 KDIGO clinical practice
by GFR-estimating method: The Third National Health and
guideline for the care of kidney transplant recipients. American
Nutrition Examination Survey (1988-1994). Nephrology, Dialysis,
Journal of Kidney Diseases 2010: 56: pp 219-246.
Transplantation 2010: February 22 [Epub ahead of print].
144
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Koshy SM, Guttmann A, H├йbert D, Parkes RK, Logan AG:
Reidy KJ, Rosenblum ND. Cell and molecular biology of kidney
Incidence and risk factors for cardiovascular events and
development. Seminars in Nephrology 2009: 29: pp 321-337.
death in pediatric renal transplant patients: A single center
long-term outcome study. Pediatric Transplantation 2009: 13:
Rosenblum ND, Bazett-Jones D, OтАЩBrodovich H: A Scientist
pp 1027-1033.
Track Investigator Program to Support Early Career Outcomes
Koshy SM, H├йbert D, Lam K, Stukel TA, Guttmann A: Renal
pp 603-604.
for Clinician Scientists. Journal of Pediatrics 2009: 155(5):
allograft loss during transition to adult healthcare services
among pediatric renal transplant patients. Transplantation
Sharan S, Dupuis A, H├йbert D, Levin AV: The effect of oral
2009: 87: pp 1733-1736.
acetazolamide on weight gain in children. Canadian Journal
of Ophthalmology 2010: 45: pp 41-45.
Licht C, Pluthero FG, Li L, Christensen H, Habbig S, Hoppe B,
Geary DF, Zipfel PF, Kahr WH: Platelet-associated complement
Sienna JL, Saqan R, Teh JC, Frieling ML, Secker D, Cornelius V,
factor H in healthy persons and patients with atypical HUS.
Geary DF: Body size in children with chronic kidney disease
Blood 2009: 114(20): pp 4538-4545.
after gastrostomy tube feeding. Pediatric Nephrology 2010:
25(10): pp 2115-2121.
Malhotra A, Igo RP Jr, Thameem F, Kao WH, Abboud HE,
Adler SG, Arar NH, Bowden DW, Duggirala R, Freedman BI,
Smeeton J, Zhang X, Bulus N, Mernaugh G, Lange L,
Goddard KA, Ipp E, Iyengar SK, Kimmel PL, Knowler WC,
Karner CM, Carroll TJ, F├дssler R, Pozzi A, Rosenblum ND,
Kohn O, Leehey D, Meoni LA, Nelson RG, Nicholas SB, Parekh RS,
Zent R: Integrin linked kinase regulates p38MAPK-dependent
Rich SS, Chen YD, Saad MF, Scavini M, Schelling JR, Sedor JR,
cell cycle arrest in ureteric bud development. Development
Shah VO, Taylor KD, Thornley-Brown D, Zager PG, Horvath A,
2010: 137: pp 3233-3243.
Hanson RL: Genome-wide linkage scans for type 2 diabetes
mellitus in four ethnically diverse populations significant
Song X, Di Giovanni V, He N, Wang K, Ingram A, Rosenblum ND,
evidence for linkage on chromosome 4q in African Americans:
Pei Y: Systems biology of Autosomal Dominant Polycystic
The Family Investigation of Nephropathy and Diabetes
Kidney Disease (ADPKD): Computational identification of gene
Research Group. Diabetes/Metabolism Research Reviews
expression pathways and integrated regulatory networks.
2009: 25(8): pp 740-747.
Human and Molecular Genetics 2009: 18: pp 2328-2343.
Neuhaus TJ, Langlois V, Licht C: Behavioural abnormalities
Tole S, Durkan AM, Huang Y-W, Liu GY, Leung A, Jones LL,
in children with nephrotic syndrome тАУ an underappreciated
Taylor JA, Robinson LA: Thromboxane prostanoid receptor
complication of a standard treatment? Nephrology, Dialysis,
stimulation induces shedding of the transmembrane
Transplantation 2010: 25: pp 2397-2399.
chemokine, CX3CL1, yet enhances CX3CL1-dependent
leukocyte adhesion. American Journal of Physiology Cell
Plantinga LC, Fink NE, Coresh J, Sozio SM, Parekh RS,
Physiology 2010: 298:pp C1469-C1480.
Melamed ML, Powe NR, Jaar Bernard G: Peripheral vascular
disease-related procedures in dialysis patients: Predictors
Tole S, Mukovozov IM, Huang Y-W, Magalhaes MAO, Yan M,
and prognosis. Clinical Journal of the American Society of
Crow MR, Liu GY, Sun CX, Durocher Y, Glogauer M, Robinson
Nephrology 2009: 4(10): pp 1637-1645.
LA: The axonal repellent, Slit2, inhibits directional migration of
circulating neutrophils. Journal of Leukocyte Biology 2009: 86:
Prytula A, Lijima K, Kamei K, Geary DF, Gottlich E, Majeed A,
pp 1403-1415.
Taylor M, Marks SD, Tuchman S, Camilla R, Ognjanovic M,
Filler G, Smith G, Tullus K: Rituximab in refractory nephrotic
Waters AM, Licht C: aHUS caused by complement
syndrome. Pediatric Nephrology 2010: 25(3): pp 461-468.
dysregulation: new therapies on the horizon. Pediatric
Nephrology 2010: June 18 [Epub ahead of print].
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 145
Wine E, Shen-Tu G, Gareau MG, Goldberg HA, Licht C, Ngan BY,
An open-label, multi-center controlled clinical trial of
Sorensen ES, Greenaway J, Sodek J, Zohar R, Sherman PM:
Eculizumab in adolescent patients with plasma therapy
Osteopontin mediates citrobacter rodentium-induced colonic
sensitive atypical hemolytic-uremic syndrome (aHUS).
epithelial cell hyperplasia and attaching-effacing lesions.
Licht C. Alexion Pharmaceuticals, Inc. ($20,872 US for
American Journal of Pathology 2010: 177(3): pp 1320-1332.
26 week treatment protocol + $10,426 US for 26 week
extension phase per enrolled patient 2009-2010)
Xu K, Nieuwenhuis E, Cohen B, Wang W, Canty AJ, Danska J,
Coultas L, Rossant J, Wu MY, Piscione TD, Nagy A, Gossler A,
A prospective study of the multidimensional quality of life and
Hicks GG, Hui CC, Henkelman RM, Yu LX, Sled JG, Gridley T,
behavioral health of pediatric renal transplant recipients.
Egan SE: Lunatic fringe-mediated notch signaling is required
Pollock-BarZiv S, Anthony S, H├йbert D, Korus M, Langlois V,
for lung alveogenesis. American Journal of Physiology тАУ Lung,
Pool R, Robinson L, Williams A. Astellas Pharmaceuticals
Cell and Molecular Physiology 2010: 298(1): pp L45-L56.
($12,500 2009-2010)
Zipfel PF, Mache C, M├╝ller D, Licht C, Wigger M, Skerka C, for
Atypical Hemolytic Uremic Syndrome: A new pathological role
the European DEAP-HUS Study Group: DEAP-HUS: Deficiency
for complement and coagulation control in platelets. Licht C.
of CFHR plasma proteins and autoantibody-positive form of
American Society of Nephrology 2009 Norman Siegel
hemolytic uremic syndrome. Pediatric Nephrology 2010:
Research Scholar Grant ($200,000 US 2009тАУ2011)
25(10): pp 2009-2019.
Atypical Hemolytic Uremic Syndrome: A new pathological role
Books and Book Chapters
for complement and coagulation control in platelets. Kahr WA,
Saland J, Parekh RS: Dyslipidemias in renal disease. In:
Licht C. Heart and Stroke Foundation of Ontario ($290,704
Johns Hopkins Textbook of Dyslipidemia (Kwitterowich P, ed.).
2009-2012)
Lipincott, Williams and Wilkins, Baltimore, MD, 2010.
Canada Research Chair in Developmental Nephrology (Tier I).
Truong TH, Grant R, Langlois V: Renal complications. In:
Rosenblum ND. Canada Research Chairs Program
Handbook of Supportive Care in Pediatric Oncology (Abla O,
($200,000/year 2005-2012)
Breakey VR, Dupuis LL, Naqvi A, Troung TH, eds.). Jones
and Bartlett, Sudbury, MA, 2009.
Canadian Child Health Clinician-Scientist Program.
Funding
($325,000/year 2009-2015)
Rosenblum ND. Canadian Institutes of Health Research
Alport Syndrome Treatments and Outcomes Registry (ASTOR).
A prospective study of microalbuminuria in untreated boys
Canadian Paediatric Clinician Scientist Program.
with Alport Syndrome. Licht C, Kashton C. ASTOR Study тАУ
Rosenblum ND. B.C. Research Institute for ChildrenтАЩs
University of Minnesota ($36,000 US 2009-2012)
and WomenтАЩs Health ($150,000/year 2002-2015)
A multicenter, randomized, double-blind placebo-controlled
Canadian Paediatric Clinician Scientist Program. Rosenblum ND.
study to test the safety and effectiveness of Lipitor
SickKids Foundation ($300,000/year 2002-2014)
(atorvastatin) in reducing the progression of carotid IMT in early
childhood SLE: The Atherosclerosis Prevention in Pediatric
CIHR MD/PhD Grant. Rosenblum ND. Canadian Institutes of
Lupus Erythematosus (APPLE) Study. Silverman E, Harvey EA:
Health Research ($110,000/yearr 2009-2011)
National Institutes of Health тАУ National Institute of Arthritis
and Muscoskeletal and Skin Disease ($12,003 2003-2009)
CIHR MD/PhD Grant. Rosenblum ND. Canadian Institutes of
Health Research ($110,000/yearr 2009-2012)
146
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
CIHR MD/PhD Grant. Rosenblum ND. Canadian Institutes of
Multi-mode spinning disc confocal platform for live cell imaging.
Health Research ($110,000/yearr 2009-2013)
RobinsonL, Klip A, Trimble W. Canada Foundation for
Innovation ($964,325 2010-2012)
CIHR MD/PhD Grant. Rosenblum ND. Canadian Institutes of
Health Research ($110,000/yearr 2009-2014)
Notch signaling and control of podocyte cell proliferation in
development and disease. Piscione T. Kidney Foundation of
CIHR MD/PhD Grant. Rosenblum ND. Canadian Institutes of
Canada ($100,000 2009-2011)
Health Research ($110,000/yearr 2010-2015)
Predictors and consequences of chronic kidney disease.
Comprehensive multidisciplinary approach to reduce
Parekh RS, Astor B. National Institutes of Health/The
overweight and obesity post-renal transplantation.
National Institute of Diabetes and Digestive and Kidney
Langlois V, Cornelius V, Southmayd D. Transplant Centre,
Diseases ($519,186/year 2007-2011)
The Hospital for Sick Children ($8,653 2009-2010)
Regulation of the Membrane-anchored Chemokine, Fractalkine,
Control of kidney cell determination and morphogenesis by
by Thromboxane A2. Robinson L. Heart and Stroke Foundation
BMPs and beta-catenin in the normal and dysplastic kidney.
of Ontario ($268,452 2007-2010)
Rosenblum ND. Canadian Institutes of Health Research
($155,828/yearr 2008-2013)
Renal Disease Epidemiology Training Program. Parekh RS,
Klag MJ. National Institutes of Health ($287,119/year
Conversion of stable renal transplant patients from immediate-
2005-2010)
release tacrolimus (Prograf) to extended release tacrolimus
(Advagraf). H├йbert D, Robinson L, Langlois V, Nalli N, Leung C,
Role of the primary cilium in nephrogenesis. Rosenblum ND.
Pollock-BarZiv S. Astellas Pharma Canada, Inc. ($69,465
Kidney Foundation of Canada ($50,000/year 2008-2010)
2009-2010)
Slit and roundabout: New players in vascular injury. Robinson L.
Environmental exposure to metal mixtures and kidney disease.
Canadian Institutes of Health Research ($100,000 2009-2010)
Parekh RS, Fox CS. National Institutes of Health/The National
Institute of Diabetes and Digestive and Kidney Diseases
($49,000/year 2007-2012)
Study of Heart and Renal Protection (SHARP). Parekh RS.
Merck - Oxford Trials Group, Oxford, United Kingdom
($25,920/year 2004-2010)
Incidence and determinants of post myocardial infarction
sudden cardiac death in South Indians. Parekh RS. Johns
The role of MYH9 in renal transplantation. Parekh RS
Hopkins Global Health ($50,000/year 2009-2010)
(co-investigator). Johns Hopkins University-Institute for
Clinical and Translational Research (ICTR) Accelerated
KidCOM-Study. Licht C. The Foundation for Children with
Translational Incubator Pilot (ATIP) Program ($100,000/year
Atypical HUS ($5,000 2009)
2010-2011)
Longitudinal study of dialysis. Parekh RS. National Institutes
The role of notch signaling in focal segmental glomerulosclerosis.
of Health /The National Institute of Diabetes and Digestive
Piscione T. The American Society of Nephrology ($200,000
and Kidney Diseases ($452,033/year 2007-2012)
2007-2009)
Mineralization factors and atherosclerotic risk in dialysis.
Parekh RS. Abbott ($222,381/year 2009-2010)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 147
Division Head
Dr. O. Carter Snead III
Full-Time
Dr. Rand Askalan
Dr. Brenda Banwell
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Gabrielle deVeber
Elizabeth Donner
Cecil Hahn
Daune MacGregor
Berge Minassian
Mahendranath Moharir
Dr.
Dr.
Dr.
Dr.
Teesta Soman
Ingrid Tein
Jiri Vajsar
Shelly Weiss
Part-Time
Dr. Danielle Andrade
Dr. Jonathan Gladstone
Dr. Cristina Go
Dr. Jeffrey Kobayashi
Dr. Betty Koo
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Wayne Langburt
Christine Lay
Shanna Lindsay
William Logan
Gilbert Miller
Peter Rumney
Division of Neurology
Divisional Overview
Kobayashi J: 25 Year Service Award, University of Toronto,
The major foci of the clinical activities of the Division of
March 2010.
Neurology are epilepsy, stroke, headache, neurometabolic
disease, neuromuscular disease, neurogenetics, sleep
MacGregor D: OHA Health Achieve Leading Practices Award:
disorders, movement disorders, demyelinating diseases,
Transition to Rehab-Going with the тАШFloтАЩ, 2009; Council Award
functional neuroimaging, and neurointensive care.
of the College of Physicians and Surgeons of Ontario, 2009.
The Division of Neurology has a Royal College-accredited
MacGregor D: Paediatric Academic Leadership Award,
training program in Child Neurology as well as postdoctoral
Paediatric Chairs of Canada, 2010.
training programs in epilepsy, stroke, neurometabolic disease
and demyelinating diseases. In addition, there are a number
Minassian B: Physician Researcher Award for Scientific
of graduate students and postdoctoral fellows in clinical
Accomplishment, University of Toronto, Department of
neurophysiology, neurogenetics, molecular and cellular
Pediatrics, 2009.
neurobiology.
Moharir M: William A. Hawke Award for Excellence in Clinical
The research foci of the Division of Neurology is epilepsy
Teaching, Division of Neurology, The Hospital for Sick Children,
(both clinical and basic research), magnetoencephalography,
2010.
stroke, dyslexia, burden of disease and quality of life, muscular
dystrophy, multiple sclerosis, fatty acid oxidation disorders and
Ochi A: Nomination for the 2010 Robert Salter Humanitarian
molecular and cellular neurobiology.
Award, 2010.
Honours and Awards
Otsubo H: Best paper presented at the 2010 Japan Child
Al-Zaidy S: CanMeds Trainee Award, Division of Neurology,
Neurology Society Meeting.
Hospital for Sick Children, 2010.
Publications
deVeber G: American Academy of Neurology тАЬSidney Carter
Abend NS, Dlugos DJ, Hahn CD, Hirsch LJ, Herman ST: Use of
AwardтАЭ (awarded every 2 years to an outstanding Pediatric
EEG monitoring and management of non-convulsive seizures in
Neurologist), 2010.
critically ill patients: A survey of neurologists. Neurocritical
Care 2010: 12: pp 382-389.
Donner E: Epilepsy Toronto H.O.P.E. Award, in recognition of
outstanding contributions to the epilepsy community, 2010.
Akiyama T, Otsubo H: Antiepileptic drugs in North America.
Brain and Nerve 2010: 62: pp 519-526.
Donner E: Junior Faculty Award for Clinical Excellence in
Paediatric Medical Care, Department of Paediatrics, Hospital
Andrade DM: Genetic basis in epilepsies caused by malformations
for Sick Children, University of Toronto, 2010.
of cortical development and in those with structurally normal
brain. Human Genetics 2009: 126(1): pp 173-193.
Donner E: CanMeds Faculty Award, Division of Neurology,
Hospital for Sick Children, 2010.
Andrade DM, Hamani C, Lozano AM, Wennberg RA: Dravet
syndrome and deep brain stimulation: Seizure control after 10
Elbers J: William J. Logan Award for Excellence in Clinical Teaching,
years of treatment. Epilepsia 2009: November 16 [Epub ahead
Division of Neurology, The Hospital for Sick Children, 2010.
of print].
Cross-Appointees
Dr. Evdokia Anagnostou
Dr. Darcy Fehlings
Dr. Golda Milo-Manson
Dr. Wendy Roberts
Dr. Elysa Widjaja
Honourary
Dr. D. Berbrayer
Dr. F. Coceani
Dr. K. Haka-Ikse
Dr. John Lovering
Dr. E. Gordon Murphy
Dr. Diann Superina-Bell
Scientific Staff
Dr. Miguel Cortez
Dr. Elizabeth Kerr
Dr. Maureen Lovett
Dr. James MacFarlane
Dr. Ayako Ochi
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Hiroshi Otsubo
Elizabeth Pang
Jose Luis Perez Velazquez
Mary Lou Smith
Margot Taylor
Robyn Westmacott
Subspecialty Residents
Dr. Reem Al-Khater
Dr. Samiah Al-Zaidy
Dr. Aly Shah Nadir Aziz
Dr. Cyrus Boelman
Dr. John Brandsema
Andrade DM, Hamani C, Minassian BA: Treatment options for
Benifla M, Sala F, Jane J Jr, Otsubo H, Ochi A, Drake J,
epileptic myoclonus and epilepsy syndromes associated with
Donner E, Fujimoto A, Holowka S, Widjaja E, Snead OC III,
myoclonus. Expert Opinion on Pharmacotherapy 2009: 10(10):
Smith ML, Tamber MS, Rutka JT: Neurosurgical management
pp 1549-1560.
of intractable Rolandic epilepsy in children: Role of resection
Andrade DM, MacAndrews, MP, Hamani C, Angel M, Wennberg
4(3): pp 199-216.
in eloquent cortex. Journal of Neurosurgery Pediatrics 2009:
RA: Seizure recurrence 29 years after hemispherectomy for
Sturge-Weber syndrome. Canadian Journal of Neurological
Bernard T, Goldenberg N, Fullerton H, Gordon A, deVeber G:
Prognostic predictors for outcome after childhood stroke,
Sciences 2010: 37(1): pp 141-144.
AuthorтАЩs Reply. Lancet Neurology 2010: 9(2): pp 141-142.
Andrew M, Monagle P, Goldenberg N, Bernard T, Fullerton H,
Gordon A, deVeber G for the International Pediatric Stroke
Bhardwaj RD, Mahmoodabadi SZ, Otsubo H, Snead OC,
Study Group: Antithrombotic treatments, outcomes, and
Rutka JT, Widjaja E: Diffusion tensor tractography detection
prognostic factors in acute childhood-onset arterial ischemic
of functional pathway for the spread of epileptiform activity
stroke: A multicentre, observational, cohort study. Lancet
between temporal lobe and Rolandic region. ChildтАЩs Nervous
Neurology 2009: 8(12): pp 1120-1127.
System 2010: 26(2): pp 185-190.
Askalan R, Salweski R, Tuor UI, Hutchison J, Hawkins C:
Callen DJA, Shroff MM, Branson HM, Li DK, Lotze T,
X-linked inhibitor of apoptosis protein (XIAP) expression
Stephens D, Banwell B: The role of MRI in the differentiation of
following ischemic injury in the human and rat developing brain.
ADEM from MS in children. Neurology 2009: 72: pp 968-973.
Pediatric Research 2009: 65: pp 21-26.
Chan DW, Yamazaki M, Akiyama T, Chu B, Donner EJ,
Banwell B, Kennedy J, Sadovnick DL, Arnold DL, Magalhaes S,
Otsubo H: Rapid oscillatory activity in delta brushes of
Wambera K, Connolly MB, Yager J, Mah J, Shah N, Sebire G,
premature and term neonatal EEG. Brain and Development
Meaney B, Dilenge ME, Lortie A, Whiting S, Doja A, Levin S,
2010: 32: pp 482-486.
MacDonald A, Meek D, Wood E, Lowry N, Buckley D, Yim C,
Awuku M, Guimond C, Cooper P, Maison FG, Baird B, Bhan V,
Chan V, McCabe J, MacGregor DL: Botox treatment for migraine
Bar-Or A: The incidence of acquired demyelination of the
and chronic daily headache in adolescents. Journal of
central nervous system in Canadian children. Neurology 2009:
Neuroscience Nursing 2009: 41(5): pp 235-243.
72: pp 232-239.
Clapcote S, Duffy S, Xie G, Kirshenbaum G, Bechard AR,
Baskin B, Banwell B, Al Khater R, Hawkins C, Ray PN: Becker
Schack VR, Peterson J, Sinai L, Saab BJ, Lerch JP, Minassian BA,
muscular dystrophy caused by a unique intronic mutation
Ackerley CA, Sled JG, Cortez MA, Henderson JT, Vilsen B,
reducing the efficiency of the splice donor site of intron 26 of
Roder JC: Mutation I810N in the alpha3 isoform of Na+K+-
the dystrophin gene. Neuromuscular Disorders 2009: 19(3):
ATPase causes impairments in the sodium pump and
hyperexcitability in the CNS. Proceedings of the National
pp 189-192.
Academy of Science USA 2009: 106(33): pp 14085-14090.
Bayle DJ, Taylor MJ: Attention inhibition of early cortical
activation to fearful faces. Brain Research 2010: 1313:
pp 113-123.
Dr. Ana Marissa LagmanBartolome
Dr. Naila Makhani
Dr. Dragos Nita
Dr. Lance Rodan
Clinical Fellows
Dr. Kevin Jones
Dr. Manish Parakh
Dr. Sorawit Viravan
Dr. Eppie Yiu
Departmental Fellows
Dr. Omer Bar Yosef
Dr. Manesh Parakh
Dr. Klaus Werner
Epilepsy Fellows
Dr. Tomoyuki Akiyama
Dr. Ali Al-Otaibi
Dr. Juan Pablo Appendino
Dr. Odeya Bennett-Back
Dr. Blathnaid McCoy
Neurodevelopmental
Fellow
Dr. Ghassan Abu Kuwaik
Neurometabolic Fellow
Dr. Zarazuela Zolkipli
Clarke J, Maegawa G, Banwell B, Blaser S, Hawkins C, Hayes J:
Fayed N, Kerr EN: Comparing quality of life scales in childhood
Pharmacokinetics, safety and tolerability of miglustat in the
epilepsy: WhatтАЩs in the measures? International Journal of
treatment of pediatric patients with GM2 gangliosidosis.
Disability, Community & Rehabilitation 2009: 8(03): E publication.
Molecular Genetics and Metabolism 2009: 97(4): pp 284-291.
Fujiwara H, Otsubo H: Source localization of
Cornette L, deVeber G, Govaert P: Perinatal stroke. Seminars
magnetoencephalography for pediatric epilepsy.
in Fetal and Neonatal Medicine 2009: 14(5): pp 243-244.
Rinsho-Kenza (Japan) 2009: 53: pp 1057-1064.
Cortez MA, Li C, Whitehead S, Dhani SU, DтАЩAntonio C,
Gaetz W, Macdonad M, Cheyne D, Snead OC: Neuromagnetic
Huan U, Steffany, Bennett AL, Snead OC 3rd, Bear CE:
imaging of movement-related cortical oscillations in children
Disruption of CIC-2 expression is associated with progressive
and adults: Age predicts post-movement bet rebound.
neurodegneration in aging mice. Neuroscience 2010: 167(1):
Neuroimage 2010: 51(2): pp 792-807
pp 154-62.
Galicia E, Imai K, Mohamed IS, Go C, Fujimoto A, Ochi A,
Couto JM, Livne-Bar I, Huang K, Xu Z, Cate-Carter T, Feng Y,
Sakuta R, Halliday W, Rutka JT, Chuang SH, Snead OC 3rd,
Wigg K, Humphries T, Tannock R, Kerr, EN, Lovett MW,
Otsubo H: Changing ictal-onset EEG patterns in children with
Bremner R, Barr CL: Association of reading disabilities with
cortical dysplasia. Brain and Development 2009: 31(8):
regions marked by acetylated H3 histones in KIAA0319.
pp 569-576.
American Journal of Medical Genetics (Neuropsychiatric
Genetics) 2010: 153B: pp 447-462.
Georgiades S, Papageorgiou V, Anagnostou E: Brief report:
Dennis M, Salman MS, Jewell D, Hetherington R, Spiegler BJ,
spectrum disorder. Journal of Autism and Developmental
MacGregor DL, Drake JM, Humphreys RP, Gentili F: Upper limb
Disorders 2010: January 28 [Epub ahead of print].
Repetitive behaviours in Greek individuals with autism
motor function in young adults with spina bifida and hydrocephalus.
ChildтАЩs Nervous System 2009: 25(11): pp 1447-1453.
Gladstone J: From psychoneurosis to ICHD-2: An overview of
deVeber G: Delays in the timely diagnosis of stroke in children.
2009: 49(7): pp 1097-1111.
the state of the art in post-traumatic headache. Headache
Nature Neurology 2010: 6: pp 64-66.
Goldenberg N, Bernard T, Fullerton H, Gordon A, deVeber G; for
Dracopoulos A, Widjaja E, Raubaud C, Westall CA, Snead OC:
the International Pediatric Stroke Study Group. Antithrombotic
Vigabatrin-associated reversible MRI signal changes in patients
treatments, outcomes, and prognostic factors in acute
with infantile spasms. Epilepsia 2010: 51: pp 1297-1304.
childhood-onset arterial ischemic stroke: A multicentre,
observational, cohort study. Lancet Neurology 2009: 8(12):
Engle J, Smith ML: Attention and material-specific memory in
pp 1120-1127.
children with lateralized epilepsy. Neuropsychologia 2010: 48:
Govaert P, Ramenghi L, Taal R, de Vries L, deVeber G: Diagnosis
pp 38-42.
of perinatal stroke I: Definitions, differential diagnosis and
Evans JW, Todd RM, Taylor MJ, Strother SC: Group specific
registration. Acta Paediatrica 2009: 98(10): pp 1556-1567.
optimisation of fMRI processing steps for child and adult data.
NeuroImage 2010: 50: pp 479-490.
Neuromuscular Fellow
Dr. Heghine Muradyan
Demyelinating Disease
Fellow
Dr. Sunita Venkateswaran
Research Fellows
Dr. Mari Akiyama
Dr. Sylvia Doo
Dr. Miho Miyajima
Dr. Lakshmi Nagarajan
Stroke Fellows
Dr. Nomazulu Dlamini
Dr. Jorina Elbers
Administrative Staff
Cecilia Amorim
Erin Crawford
Maureen Hodge
Fatima Ledo
Michelle Lo
Marilyn McLaughlin
Susy OтАЩNeill
Wendy Ricketts
Ramona Zacharias
Barbara Zimnowodzki
Hajek J, Yau Y, Kertes P, Soman T, Laughlin S, Kanani R,
Jordan L, Rafay M, Askalan R, Smith S, deVeber G, Ashwal S:
Kazacos K, Dangoudoubiyam S. Opavsky MA: A child with
Antithrombotic treatment in neonatal cerebral sinovenous
raccoon roundworm meningoencephalitis: A pathogen emerging
thrombosis. International Pediatric Stroke Study Group:
in your own backyard? Canadian Journal of Infectious Diseases
Journal of Pediatrics 2010: 156(5): pp 704-710.
and Medical Microbiology 2009:20(4): pp e177-e180.
Kadis DS, Kerr EN, Rutka JT, Snead OC, Weiss SK, Smith MK:
Hamani C, Andrade DM, Wennberg RA, Hodaie M, Lozano A:
Pathology type does not predict language lateralization in
Deep brain stimulation for the treatment of epilepsy. International
children with medically intractable epilepsy. Epilepsia 2009:
Journal of Neural Systems 2009: 19(3): pp 213-226.
50: pp 1498-1504.
Hartley J, Westmacott R, Decker J, Shroff M, Yoon G:
Kenet G, L├╝tkhoff LK, Albisetti M, Bernard T, Bonduel M,
Childhood-onset CADASIL: Clinical, imaging and neurocognitive
Brandao L, Chabrier S, Chan A, deVeber G, Fiedler B,
features. Journal of Child Neurology 2010: 25(5): pp 623-627.
Fullerton HJ, Goldenberg NA, Grabowski E, G├╝nther G, Heller C,
Hollander E, Chaplin W, Soorya L, Wasserman S, Novotny S,
Kurnik K, Lynch JK, Male C, Manco-Johnson M, Mesters R,
Rusoff J, Feirsen N, Pepa L, Anagnostou E: Divalproex sodium
Monagle P, van Ommen CH, Raffini L, Rost├бsy K, Simioni P,
Holzhauer S, Iorio A, Journeycake J, Junker R, Kirkham FJ,
vs placebo for the treatment of irritability in children and
Str├дter RD, Young G, Nowak-G├╢ttl U: Impact of thrombophilia
adolescents with autism spectrum disorders.
on risk of arterial ischemic stroke or cerebral sinovenous
Neuropsychopharmacology 2010: 35(4): pp 990-998.
thrombosis in neonates and children: a systematic review
Hum KM, Smith ML, Lach L, Elliott IM: Self-perceptions of
121(16): pp 1838-1847.
and meta-analysis of observational studies. Circulation 2010:
social function two years after epilepsy surgery. Epilepsy
and Behavior 2010: 17(3): pp 354-359.
Kerr EN, Ellis L, Dupuis A, Rommens JM, Durie PR: The
Hung RM, Yoon G, Hawkins CE, Halliday W, Biggar D, Vajsar J:
Diamond syndrome indicates neurocognitive dysfunction with
behavioral phenotype of school-aged children with Shwachman
Cap myopathy caused by a mutation of the skeletal alpha-actin
loss of Shwachman-Bodian-Diamond syndrome gene function.
gene ACTA1. Neuromuscular Disorders 2010: 20(4): pp
Journal of Pediatrics 2010: 156(3): pp 433-438.
238-240.
Kirton A, deVeber G, Gunraj C, Chen R. Cortical excitability
Hung YI, Smith ML, Bayle DJ, Mills T, Cheyne DO, Taylor MJ:
and interhemispheric inhibition after subcortical pediatric
Unattended fear elicits early frontal-amygdala and fusiform
stroke: Plastic organization and effects of rTMS. Clinical
activations. NeuroImage 2010: 50: pp 727-733.
Neurophysiology 2010: May 26 [Epub ahead of print].
Huo J, Cortez MA, Snead OC III: GABA receptor proteins within
Klaus V, Vermeulen T, Minassian BA, Israelian N, Engel K,
lipid rafts in the AY-9944 model of atypical absence seizures.
Lund A, Roebrock K, Haberle J: Highly variable clinical
Epilepsia 2009: 50(4): pp 776-788.
phenotype of carbamylphosphate synthetase 1 deficiency in
one family: An effect of allelic variation in gene expression?
Jewell D, Fletcher JM, Mahy CE, Hetherington R, MacGregor D,
Clinical Genetics 2009: 76: pp 263-269.
Drake JM, Salman MS, Dennis M: Upper limb cerebellar motor
function in children with spina bifida. ChildтАЩs Nervous System
Kolski H, Vajsar J, Grenier D: Paediatric myasthenia: A moving
2009: October 13 [Epub ahead of print].
target. Paediatrics & Child Health 2010: 15(4): p 226.
152
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Kousi M, Siintola E, Dvorakova L, Vlaskova H, Turnbull J, Topcu M,
Makhani N, Gorman MP, Branson HM, Stazzone L, Banwell B,
Yuksel D, Gokben S, Minassian BA: Mutations in CLN7/MFSD8
Chitnis T: Cyclophosphamide therapy in pediatric multiple
are a common cause of variant late-infantile neuronal ceroid
sclerosis. Neurology 2009: 72(24): pp 2076-2082.
lipofuscinosis. Brain 2009: 132(pt 3): pp 810-819.
Malik V, Rodino-Klapac LR, Viollet L, Wall C, King W, Al-Dahhak R,
Lamhonwah AM, Bear CE, Huan LJ, Ackerley C, Tein I: Cystic
Lewis S, Shilling CJ, Kota J, Serrano-Munuera C, Hayes J,
fibrosis transmembrane conductance regulator in human
Mahan JD, Campbell KJ, Banwell B, Dasouki M, Watts V,
muscle: Dysfunction causes abnormal metabolic recovery
Sivakumar K, Bien-Willner R, Flanigan KM, Sahenk Z, Barohn
in exercise. Annals of Neurology 2010: 67(6): pp 802-808.
RJ, Walker CM, Mendell JR: Gentamicin-induced readthrough
of stop codons in Duchenne muscular dystrophy. Annals of
Latinus, M, VanRullen R, Taylor MJ: Top-down and bottom-up
Neurology 2010: 67(6): pp 771-780.
attentional modulation in processing bimodal face/voice
stimuli. BMC Neuroscience 2010: 11: p 36.
McLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J,
Laughon M, OтАЩShea MT, Allred EN, Bose C, Kuban K,
Ness JM, Tenembaum S, OтАЩConnor KC, Viglietta V, Wong SJ,
Van Marter LJ, Ehrenkranz RA, Leviton A; ELGAN Study
Tavakoli NP, de Seze J, Idrissova Z, Khoury SJ, Bar-Or A,
Investigators: Chronic lung disease and developmental delay
Hafler DA, Banwell B, Wucherpfennig KW: Age-dependent
McArdel S, Kuhle J, Kappos L, Rostasy K, Pohl D, Gagne D,
at 2 years of age in children born before 28 weeks gestation.
B cell autoimmunity to a myelin surface antigen in pediatric
Pediatrics 2009: 124 (2): pp 637-648.
multiple sclerosis. The Journal of Immunology 2009: 183(6):
pp 4067-4076.
Lay CL, Broner SW: Migraine in women. Neurologic Clinics
2009: 27(2): pp 503-511.
McMillan HJ, Campbell C, Mah JK; Canadian Paediatric
Lovett M, Bremner R, Barr CL: Association of reading
Canadian paediatric neuromuscular physicians survey.
disabilities with regions marked by acetylated H3 histones
Canadian Journal of Neurological Science 2010: 37(2):
in KIAA0319. American Journal of Medical Genetics Part B
pp 195-205.
Neuromuscular Group: Duchenne muscular dystrophy:
2009: 153B: pp 447-462.
Miller E, Widjaja E, Nilsson D, Yoon G, Banwell B, Blaser S:
Mabbott DJ, Rovet J, Noseworthy MD, Smith ML, Rockel C:
Magnetic resonance imaging of a unique mutation in a family
The relations between white matter and declarative memory in
with Pelizaeus-Merzbacher Disease. American Journal of
older children and adolescents. Brain Research 2009: 1294:
Medical Genetics 2010: 152A(3): pp 748-752.
pp 80-90.
Moharir MD, Shroff M, Stephens D, Pontigon AM, Chan A,
Maegawa GHB, Banwell B, Blaser S, Hawkins C, Ackerley C,
MacGregor D, Mikulis D, Adams M, deVeber G: Anticoagulants
Hayes J, Toplak M, Sorge G, Clarke JTR: Substrate reduction
in pediatric cerebral sinovenous thrombosis: A safety and
therapy in juvenile GM2 gangliosidosis. Molecular Genetics
outcome study. Annals of Neurology 2010: 67(5): pp 590-599.
and Metabolism 2009: 98(1-2): pp 215-224.
Ng D, Pitcher GM, Szilard RK, Sertie A, Kanisek M, Clapcote SJ,
Maegawa GH, van Giersbergen PL, Yang S, Banwell B,
Lipina T, Kalia LV, Joo D, McKerlie C, Cortez MA, Roder JC,
Morgan CP, Dingemanse J, Tifft CJ, Clarke JT: Pharmacokinetics,
Salter MW, McInnes RR: Neto 1, a novel CUB-domain NMDA
safety and tolerability of miglustat in the treatment of pediatric
receptor interacting protein required for synaptic plasticity and
patients with GM2 gangliosidosis. Molecular Genetics and
learning. PLoS Biology 2009: 7(2): p e41.
Metabolism 2009: 97(4): pp 284-291.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 153
Ng W, Ochi A, Rutka JT, Otsubo H: Stimulation threshold
Perez Velazquez JL: Actividad coordinada en el cerebro: reflejo
potentials of intraoperative cortical motor mapping using
y determinante de comportamientos. Ciencia Cognitiva: Revista
monopolar trains of five in pediatric epilepsy surgery.
Electronica de Investigacion 2009: 3: pp 72-75.
ChildтАЩs Nervous System 2010: 26(5): pp 675-679.
Perez Velazquez JL: Finding simplicity in complexity: General
Normann S, deVeber G, Fobker M, Langer C, Kenet G,
principles of biological and nonbiological organization. Journal
Bernard T, Fiedler B, Strater R, Goldenberg N, Nowak-Gottl U:
of Biological Physics 2009: 35: pp 209-221.
Role of endogenous testosterone concentration in pediatric
stroke. Annals of Neurology 2009: 66(6): pp 754-758.
Perez Velazquez JL, Barcelo F, Hu Y, Leshchenko Y,
Nenadovic V, Belkas J, Raghavan V, Brian J, Garcia Dominguez L:
OтАЩConnor KC, Lopez-Amaya C, Gagne D, Lovato L,
Decreased brain coordinated activity in autism spectrum
Moore-Odom NH, Kennedy J, Krupp L, Tenembaum S, Ness J,
disorders during executive tasks: Reduced long-range
Belman A, Boyko A, Bykova O, Mah JK, Stoian CA, Waubant E,
synchronization in the fronto-parietal networks. International
Kremenchutzky M, Ruggieri M, Bardini MR, Rensel M, Hahn J,
Journal of Psychophysiology 2009: 73: pp 341-349.
Weinstock-Guttman B, Yeh EA, Farrell K, Freedman MS,
Iivanainen M, Bhan V, Dilenge M, Hancock MA, Gano D,
Poma R. Ochi A, Cortez MA: Absence seizures with myoclonic
Fattahie R, Kopel L, Fournier AE, Moscarello M, Banwell B,
features in a juvenile chihuahua dog. ACP Journal Club/Annals
Bar-Or A: Anti-myelin antibodies modulate clinical expression
of Internal Medicine 2010: 12(2): pp 138-141.
of childhood multiple sclerosis. Journal of Neuroimmunology
2010: 223(1-2): pp 92-99.
Poochikian-Sarkissian S, Tai P, del Campo M, Andrade DM,
Carlen PL, Valiante T, Wennberg RA: Patient awareness of
Pang EW, Gaetz W, Drake JM, Strantzas S, MacDonald MJ,
seizures as documented in the epilepsy monitoring unit.
Otsubo H, Snead OC: Patient with post-central gyrectomy
Canadian Journal of Neuroscience Nursing 2009: 31(4):
demonstrates reliable localization of hand motor area using
pp 22-23.
magnetoencephalography (MEG): Case Report. Pediatric
Neurosurgery 2009: 45: pp 311-316.
Quercia N, Somers GR, Halliday W, Kantor PF, Banwell B,
Yoon G: Friedreich ataxia presenting as sudden cardiac death
Payne J, Moharir M, Webster R, North K: Brain structure and
in childhood: Clinical, genetic and pathological correlation, with
function in neurofibromatosis type-1: Current concepts and
implications for genetic testing and counselling. Neuromuscular
future directions. Journal of Neurology, Neurosurgery and
Disorders 2010: 20(5): pp 340-342.
Psychiatry 2010: 81: pp 304-309.
Rafay M, Cortez M, deVeber G, Tan-Dy C, Alfutaisi A, Yoon W,
Pearl PL, Gibson KM, Cortez MA, Wu Y, Snead OC 3rd, Knerr I,
Fallah S, Moore A: Predictive value of clinical and EEG features
Forrester K, Jakobs C, Theodore WH: Succinic semialdehyde
in the diagnosis of stroke and hypoxic ischemic encephalopathy
dehydrogenase deficiency: Lessons from mice and men.
in neonates with seizures. Stroke 2009: 40(7): pp 2402-2407.
Journal of Inherited Metabolic Disease 2009: 32(3): pp
343-352.
Ramachandran N, Girard JM, Turnbull J, Minassian BA:
The autosomal recessively inherited progressive myoclonus
Pederson CB, Zolkipli Z, Vang S, Palmfeldt J, Kjeldsen M,
epilepsies and their genes. Epilepsia 2009: 50(Supp 5):
Stenbroen V, Schmidt SP, Wanders RJA, Ruiter JPN, WIbrand F,
pp 29-36.
Young SP, Millington DS, Tein I, Gregersen N: Antioxidant
dysfunction: Potential risk for neurotoxicity in ethylmalonic
Ramachandran N, Munteanu I, Wang P, Aubourg P, Rilstone JJ,
aciduria. Journal of Inherited Metabolic Diseases 2010: 33(3):
Isrealian N, Naranian T, Paroutis P, Guo R, Ren ZP, Nishino I,
pp 211-222.
Chabrol B, Pellissier JF, Minetti C, Udd B, Fardeau M, Tailor CS,
Mahuran DJ, Kissel JT, Kalimo H, Levy N, Manolson MF,
154
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Ackerley CA, Minassian BA: VMA21 deficiency causes an
Stewart LS, Wu Y, Eubanks J, Han A, Leschenko Y, Perez
autophagic myopathy by compromising V-ATPase activity and
Velazquez, JL, Cortez MA, Snead OC: Mice over-expressing
lysosomal acidification. Cell 2009: 137(2): pp 235-246.
GABABR1b receptor subtype show evidence of an atypical
absence seizure phenotype. Epilepsy and Behavior 2009: 14:
Rea D, Brandsema JF, Armstrong D, Parkin P, deVeber G,
pp 577-581.
MacGregor D, Logan W, Askalan R: Cerebral arteriopathies in
children with neurofibromatosis type 1. Pediatrics 2009: 124:
pp e476-e483.
Striano P, Ackerley CA, Mariarosaria C, Girard JM, Turnbull J,
Del Basso-De Caro M, Striano S, Zara F, Minassian BA: 22 year
old girl with status epilepticus and progressive neurological
Saunders C, Minassian BA, Chow E, Zhao W, Vincent J: Novel
symptoms. тАЬCase of the MonthтАЭ for April 2009. Brain Pathology
exon 1 mutations in MECP2 implicate isoform MeCP2_e1 in
2009: 19(4): pp 727-730.
classical Rett Syndrome. American Journal of Medical Genetics
2009: 149A(5): pp 1019-1023.
Sugiyama I, Imai K, Akizuki Y, Yamaguchi Y, Ochi A, Akiyama T,
Cristina Go, Drake J, Rutka JT, Widjaja E, Chuang SH, Snead OC
S├йverac Cauquil A, Delaux S, Lestringant R, Taylor MJ,
III, Otsubo H: Localization of epileptic foci in children with
Trotter Y: Neural correlates of chromostereopsis: An evoked
intractable epilepsy secondary to multiple cortical tubers using
potential study. Neuropsychologia 2009: 47: pp 2677тАУ2681.
synthetic aperture magnetometry kurtosis. Journal of
Neurosurgery: Pediatrics 2009: 4: pp 515-522.
Shields WD, Snead OC: Benign epilepsy with centrotemporal
spikes. Epilepsia 2009: 50(Suppl. 8): pp 10-15.
Tan M, Armstrong D, Birken C, Bitnun A, Caldarone CA, Cox P,
Shirozu H, Iida K, Hashizume A, Hanaya R, Kiura R, Kurisu K,
child presenting with acute arterial ischemic stroke: Should
Arita K, Otsubo H: Gradient magnetic topography reflecting
thrombolytic therapy be absolutely contraindicated?
Kahr W, MacGregor D, Askalan R: Bacterial endocarditis in a
neocortical epilepsy spikes. Epilepsy Research 2010: 90:
Developmental Medicine and Child Neurology 2009: 51:
pp 121-131.
pp 151-154.
Simao G, Raybaud C, Chuang S, Go C, Snead OC, Widjaja E.
Tan M, Armstrong D, MacGregor, Kirton A: Late complications
Diffusion tensor imaging of commissural and projection white
of vertebral artery dissection in children: Pseudoaneurysm,
matter in tuberous sclerosis complex and correlation with tuber
thrombosis and recurrent stroke. Journal of Child Neurology
load. American Journal of Neuroradiology 2010: March 4 [Epub
2009: 24(3): pp 354-360.
ahead of print]
Tan M, deVeber G, Kirton A, Vidarsson L, MacGregor D,
Smith ML: тАЬI canтАЩt rememberтАЭ: Memory deficits in children with
Shroff M: Low detection rate of craniocervical arterial
epilepsy. Canadian Journal of Neurological Sciences 2009:
dissection in children using time-of-flight (TOF) magnetic
36(S.2) pp 42-45.
resonance angiography (MRA): Causes and strategies to
Smith ML: Neuropsychology in epilepsy: Children are not small
pp 1250-1257.
improve diagnosis. Journal of Child Neurology 2009: 24(10):
adults. Epilepsia 2010: 51(Suppl.1): pp 68-69.
Taylor MJ, Arsalidou M, Bayless SJ, Morris D, Evans JW,
Soman T, English A: The uses of art in the context of health
and diversity. Paediatrics & Child Health 2010: 15(1): pp 9-10.
Barbeau EJ: Neural correlates of personally familiar faces:
Parents, partner and own faces. Human Brain Mapping 2009:
30: pp 2008-2020.
Soman T, Lang AE: Movement disorders. Continuum Lifelong
Learning in Neurology 2009: 15(6): pp 167-190.
Taylor MJ, Pang EW: Using MEG to image cognition in children.
Down Syndrome Quarterly 2009: 11: pp 10-17.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 155
Trakadis Y, Blaser S, Hahn CD, Yoon G: A case report of
Widjaja E, Yeung R, Geibprasert S, Mahmoodabadi SZ,
prenatal exposure to rosuvastatin and telmisartan.
Snead OC, Smith ML. Longitudinal brain volumes in children
Paediatrics & Child Health 2009: 14 (7): pp 450-452.
with intractable partial seizures. Pediatric Neurology 2010:
42: pp 315-319.
Venkateswaran S, Banwell B: Pediatric multiple sclerosis Review. Neurologist 2010: 16(2): pp 92-105.
Widjaja E, Zaeri Mahmoodabadi S, Otsubo H, Snead OC,
Holowka S, Bells S, Raybaud C: Subcortical alterations in
Wang X, Stewart L, Cortex MA, Wu Y, Perez-Velazquez JL,
tissue microstructure adjacent to focal cortical dysplasia:
Liu CC, Shen L, Snead OC: The circuitry of atypical absence
Detection at diffusion-tensor MR imaging by using
seizures in GABABR1a transgenic mice. Pharmacology
magnetoencephalographic dipole cluster localization.
Biochemistry and Behavior 2009: 94: pp 124-130.
Radiology 2009: 251: pp 206-215.
Webb AA, McMillan C, Cullen CL, Boston SE, Turnbull J,
Wolf M, Barzillai M, Gottwald S, Miller L, Spencer K, Norton E,
Minassian BA: Lafora disease as a cause of visually
Lovett MW, Morris RD: The RAVE-O intervention: Connecting
exacerbated myoclonic attacks in a dog. Canadian Veterinary
neuroscience to the classroom. Mind, Brain, and Education
Journal 2009: 50(9): pp 963-967.
2009: 3: pp 84-93.
Wells GD, Selvadurai H, Tein I: Bioenergetic provision of
Yiu EM, Farrell SA, Soman T: Classic pelizaeus merzbacher
energy for muscular activity. Pediatric Respiratory Reviews
disease in a girl with an unbalanced chromosomal
2009: 10: pp 83-90.
translocation and functional duplication of the PLP 1 gene.
Movement Disorders 2009: 24(14): pp 2171-2172.
Wennberg R, McAndrews MP, Zumsteng D, Perez Velazquez JL:
The sign of the cross as a learned automatism? Epilepsy and
Funding
Behavior 2009: 15(3): pp 394-398.
Centre for the Study of Complex Childhood Diseases. Tein I
- Member, CFI Team. Canada Foundation for Innovation
Westmacott R, Askalan R, MacGregor D, deVeber G: Cognitive
($21,000,000 2007-2012)
outcome following unilateral ischemic stroke in childhood:
Effects of age at stroke and lesion location. Developmental
Medicine and Child Neurology 2009: 52(4): pp 386-393.
Cerebral venous hemodynamics in pediatric multiple sclerosis.
Banwell B, McGowan C, Laughlin S, Narayanan S, Sled JG,
Amit Bar-Or A, Marie RA, Yeung R, Arnold D. Multiple Sclerosis
Westmacott R, Barry V, MacGregor D, Askalan R, deVeber G:
Society ($196,579 2010-2012)
Late emergence of cognitive deficits following unilateral
neonatal stroke. Stroke 2009: 40: pp 2012-2019.
Characterization of genetic and molecular mechanisms
underlying infantile spasms. Osborne L, Minassian BA.
Widjaja E, Simao G, Mahmoodabadi SZ, Ochi A, Snead OC III,
Canadian Institutes of Health Research ($549,785 2008-2013)
Rutka J, Otsubo H: Diffusion tensor imaging identifies changes
in normal-appearing white matter within the epileptogenic zone
Childhood Obesity Research - CIHR Team. McCrindle B,
in tuberous sclerosis complex. Epilepsy Research 2010:
Anderson H, Hamilton J, Parkin P, Pencharz P, Tein I. Canadian
89(2-3): pp 246-253.
Institutes of Health Research ($2,424,738 2008-2013)
156
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Clinical and neuroimaging correlates of cognitive decline in
Development of a MEG-compatible articulography system for
children and adolescents with multiple sclerosis. Banwell B,
the assessment of brain function and oromotor dynamics.
Till C, Mabbott D, Shroff M, Sled J, Arnold D. Multiple Sclerosis
Cheyne D, Chau T, Van Lieshout P, Steele C, Pang E, Donner E.
Society of Canada ($234,021 2008-2010)
Collaborative Health Research Projects, Canadian Institutes
of Health Research ($411,184 2010-2013)
Clinical and pro-thrombotic risk factor profiles in perinatal
stroke: A case-controlled study. Kirton A, deVeber G. Alberta
Developmental investigation of memory capacity using
ChildrenтАЩs Hospital Foundation ($50,000 2009-2010)
functional neuroimaging. Taylor, MJ. Natural Sciences and
Collaborative Academic Rehabilitation Engineering (CARE).
($150,000 2009-2014)
Engineering Research Council of Canada Discovery Grant
Chau T (with Baecker R, Santerre JP, Naguib HE, Colantino A,
Fernie GR, Wong W, Steele C, Maki BE, Popovic MR, Mihailidis
Diffusion tensor imaging assessment of white matter injury
A, Soman T). Natural Sciences and Engineering Research
in children with cryptogenic epilepsy. Smith ML, Widjaja,
Council, Collaborative Research and Training Experience
Snead OC. Canadian Institutes of Health Research/SickKids
(CREATE) Program ($1,650,000 2009-2015)
Foundation ($289,043 2009-2011)
Comparative functional studies of the two MeCP2 isoforms,
Dissociating cognitive and motor components of healthy and
MeCP2e1 and MeCP2e2. Vincent J, Frankland P, Minassian BA.
dysfunctional expressive language development in children.
International Rett Syndrome Foundation ($100,000 2009-2011)
Pang EW, Cheyne D, De Nil L, Roberts SW. Canadian Institutes
of Health Research ($871,112 2008-2013)
Compression of sagittal sinus in neonates underlying
sinovenous thrombosis. deVeber G. Heart and Stroke
Forming a Canadian network for metabolic epilepsies:
Foundation of Canada - Junior Personnel Award (for
Antiquitin deficiency, newly discovered cause. Stockler S,
Dr. Nomazulu Dlamini). ($100,000 2009-2011)
Connolly M, Coulter-Mackie, Tein I (Member, CIHR Team).
Canadian Institutes of Health Research (2009-2010 $22,500)
Conscious will and voluntary actions: Is there a last
ventriloquist in the brain? Perez Velazquez JL. Bial Foundation
Genes, reading and dyslexia. Gruen J, Lovett MW, Wolf M,
($47,500 2009-2012)
Pennington B, Willcutt E, Boada R. Manton Foundation
($5,000,000 US 2009-2014)
Cooperative multi-center program for research and treatment of
autism. Roberts W, Loh A, Feigenbaum A, Weiss S, Marcon M,
Genetics and reading disabilities. Barr CL, Lovett MW, Kerr EN.
Goldfarb C, Berall G, Bradley E, Brian J, Freeman N, Atkinson A,
Canadian Institutes of Health Research ($1,053,327
Taylor MJ, Stinson J, Mitchell S, Green P. Autism Treatment
2008-2013)
Network ($300,000 2008-2010)
Genetics of reading disabilities. Barr CL, Kerr E, Lovett MW.
Cortical oscillations and altered states of consciousness: The
Canadian Institutes of Health Research ($1,026,192
study of meditative states and functional brain connectivity.
2008-2013)
Perez Velazquez JL. Bial Foundation ($48,000 2009-2011)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 157
Globus pallidus deep brain stimulation in children with dystonia.
Memantine vs placebo for the treatment of motor skill deficits
Soman T, Moro E, Lozano AM, Hodaie M, Westmacott R,
for children with autism. Anagnostou E. Autism Speaks
Gorman D. SickKids Foundation New InvestigatorтАЩs Grant
($200,000 2010-2012)
($88,617 2008-2010)
Molecular basis of Lafora bodies (starch formation in the brain)
Hypoglycemia and neuroplasticity in the neonatal period.
and LoforaтАЩs progressive myoclonus epilepsy. Minassian BA,
Shroff MM, Moore AM, Whyte HEA, Taylor MJ. Translational
Ackerley CA, Scherer SW, Lohi H. Canadian Institutes of Health
Research Grant, Dept. of Medical Imaging, University of
Research ($1,146,830 2006-2011)
Toronto ($70,000 2008-2010)
Multimodal neuroimaging of frontal lobe cognitive function in
Identification of genetic causes of pediatric neurological
children. Taylor M, Donner EJ, Pang E. Canadian Institutes of
conditions and using these to uncover the cellular pathways
Health Research ($466,335 2006-2010)
involved and to determine the ways in which they are disturbed.
Minassian BA. Canada Research Chairs Program ($478,585
Multimodal neuroimaging and neurobehavioural outcomes in
2006-2011)
preterm neonates. Taylor M, Whyte H, Shroff M, Donner EJ,
Moore A. Canadian Institutes of Health Research ($925,000
Immune regulation and biomarker development for pediatric
2007-2012)
and adult autoimmune diseases. Bar-Or A, Banwell B, Piccirillo P,
Sherman P, Polychronakos C. Canadian Institutes of Health
Research - New Emerging Team Grants ($2,018,445 2007-2012)
Multiple-component remediation for struggling middle school
readers. Morris R, Lovett MW, Sevcik R, Frijters JC. Institute
of Education Sciences ($2,882,630 US 2006-2010)
Intranasal oxytocin for the treatment of children and
adolescents with autism spectrum disorders. Anagnostou E,
Murine knockout model of 4-hydroxybutyric aciduria. Snead C,
Roberts W, Brian J. Department of Defense ($805,791
Gibson D. National Institutes of Health ($470,000 US
2010-2013)
2006-2010)
Making a better brain: An Ontario Neuroimaging Consortium.
Neuroimaging measures of brain function in preterm neonates.
Menon RS, Bartha R, Chronik BA, Henkelman M, Kassner A,
Taylor M, Donner EJ, McNamara PJ, Moore AM, Shroff MM,
Lee TY, Mikulis D, Moller HJ, Rutt BK, Sled JG, Taylor MJ.
Sled JG, Whyte HEA. Natural Sciences and Engineering
Ontario Research Foundation (ORF) ($4,161,595 2008-2011)
Research Council of Canada ($361,860 2008-2011)
Mapping and modulation of brain plasticity in perinatal stroke.
Neuromuscular/EMG Fellow Funding Dr. H. Muradyan. Vajsar J.
Kirton A, Chen R, Demchuk A, Hill MD, Barlow K, Howard J,
International Federation of Clinical Neurophysiology ($25,000
deVeber G. Heart and Stroke Foundation (New Investigator
2009-2010)
Award) ($300,000 2009-2014)
Neuroprotection by inhibitors of apoptosis proteins following
MEB Diseases. Vajsar J. SickKids Foundation ($37,000
2006-2010)
neonatal stroke. Askalan R. Heart and Stroke Foundation of
Ontario (Clinician-Scientist Award - Phase I) ($150,000
2007-2010)
Mechanism of hand dystonia in children with basal ganglia
stroke using transcranial magnetic stimulation. Askalan R,
Nonconvulsive seizures among critically ill children. Hahn CD,
Billinghurst L. Padden Family Pediatric Stroke Fund -
Hutchison J, Snead C, Parshuram C, Otsubo H. SickKids
SickKids Foundation ($12,000 2008-2010)
Foundation/Canadian Institutes of Health Research - New
Investigator Research Grant ($431,694 2009-2012)
158
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Nonconvulsive seizures among critically ill children:
Role of carnitine/organic cation transporters in the
A prospective study to determine incidence, risk factors
mammary gland and implications for the suckling infant.
and outcomes. Hahn C, Otsubo, H. Physicians Services
Tein I. Mead-Johnson Grant ($13,790 2010-2011)
Incorporated Foundation ($167,000 2010-2012)
Spatio-temporal patterns of synchronized brain activity.
Ontario-Manitoba Regional Research Training Center.
Perez Velazquez JL. National Sciences and Engineering
Banwell B, OтАЩConnor P, Marie R-A. Multiple Sclerosis
Research Council of Canada Discovery Grant ($172,165
of Society of Canada ($300,000 2009-2011)
2007-2011)
Open Fellowship for Hua (Alex) Han. Snead OC. University
The ChildrenтАЩs Stroke Project. deVeber G. Anonymous
of Toronto ($5,000 2009)
ChildrenтАЩs Foundation ($1,800,000 2009-2014)
Paediatric myasthenia. Kolski H, Vajsar J. Canadian Paediatric
The clinical-demographic, epidemiology, pathobiology,
Surveillance Program ($42,000 2010-2011)
neuroimaging features and outcome of acute demyelination
Preconditioning against periventricular leukomalacia associated
Marie RA, Arnold D, on behalf of the Canadian Pediatric
in Canadian children. Banwell B, Amit Bar-Or A, Sadovnick D,
with neonatal cardiac surgery. Askalan R, Hickey E, Van Arsdell
Demyelinating Disease Network. Multiple Sclerosis Scientific
G. The ChildrenтАЩs Heart Foundation ($90,000 2008-2010)
Research Foundation ($4,653,550 2009-2012)
Predicting neurobehavioural outcome in preterm neonates.
Towards the correction of Rett-like behavior in MeCP2-deficient
Taylor MJ, Whyte HE, Raybaud C, Moore AM, Donner EJ,
mice by exogenous gene delivery. Snead OC. Canadian
Shroff MM, Frisk VA. Canadian Institutes of Health Research
Institutes of Health Research ($585,685 2004-2009)
($929,129 2007-2012)
Traumatic brain injury in children and youth: The complexities
Quantitative non-invasive MRI measures of cerebral reactivity
of co-morbidities. Hutchison J, Schachar R, Perez Velazquez JL.
in children with sickle cell disease: A valuable tool for the
Ontario Neurotrauma Foundation ($250,000 2007-2010)
assessment of vessel function and patient management.
Kassner A, deVeber G. Canadian Institutes of Health Research
Unravelling the pathogenesis of the autophagic vacuolar
($175,000 2009-2010)
myopathies. Minassian BA, Ackerley C, Manolson MF. Canadian
Institutes of Health Research ($779,395 2007-2012)
Registry for SUDEP in children. Donner EJ, Carmant L, Kinney H.
Citizens United for Research in Epilepsy ($99,900 2009-2010)
Use of multidrug resistance inhibitor verapamil in
pharmacoresistant epilepsy. Andrade D. Krembil
Restracomp Award for Hua (Alex) Han. Snead OC. SickKids
Neurosciences Program ($39,000 2008-2010)
Restracomp Award ($19,000 2009-2010)
Vascular effects of infection in pediatric stroke. deVeber G,
Role of carnitine/organic cation transporters in the
Fullerton H. National Institutes of Health ($6,815,231
mammary gland and implications for the suckling infant.
2009-2014)
Tein I. Mead-Johnson Grant ($25,000, 2009-2010)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 159
Division Head
Dr. William Mounstephen
Full-Time
Dr. Kathy Boutis
Dr. Kevin Chan
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Seen Chung
Yaron Finkelstein
Stephen Freedman
Shauna Jain
Anna Jarvis
Kelly Keogh
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Luba Komar
Amina Lalani
Sanjay Mehta
Angelo Mikrogianakis
Bruce Minnes
Trent Mizzi
Dr. Jonathan Pirie
Dr. Savithiri Ratnapalan
Dr. Susan Schneeweiss
Dr. Suzanne Schuh
Dr. Dennis Scolnik
Jennifer Thull-Freedman
Part-Time
Dr. Sherry Baine
Dr. Alexander Barron
Dr. Susanna Benseler
Dr. Carolyn Calpin
Dr. Joseph Copeland
Division of Paediatric Emergency Medicine
Divisional Overview
Research in the Division remains clinically focused, covering
The Emergency Department (ED) at SickKids provides acute
a wide range of topics from respiratory disease acute care
care to children who are ill or who have been injured. We are
management to orthopaedic injuries, and pain and sedation, to
a primary care centre for children in Toronto, as well as the
vomiting, diarrhea and dehydration. Educational research in the
tertiary referral centre for the Greater Toronto Area (GTA) and
ED has begun. Research done within the Division continues to
are the designated Paediatric Trauma Centre for the GTA. The
be presented nationally and internationally with publications
division currently has 19 full-time staff, the majority of whom
in peer-reviewed journals. Overall, the result has been a
are certified in both paediatrics and paediatric emergency
substantial increase in clinical research activities which has
medicine (PEM). The Division also has a cadre of part-time
set us on par with the other North American leaders in
paediatricians. The majority of the redevelopment of the EDтАЩs
paediatric emergency medicine.
physical plant was completed in May 2010. The redevelopment
resulted in 28 new rooms and two new nursing/work stations.
Honours and Awards
The rooms included four acute resuscitation rooms and two
Boutis K: First Prize (Supervisor), Summer Student Research
isolation rooms with anterooms. Two additional isolation rooms
Project, 2009.
without anterooms were also created. Still to be done will be
the building of a new Urgent Care area within the ED and space
Finkelstein Y: Visiting Associate Professor of Pediatrics,
for offices and a staff lounge in close proximity to the ED. The
Harvard Medical School, Boston, Massachusetts, 2009-2010.
target date for completion of this final phase of the
redevelopment will be 2011.
Finkelstein Y: Section Editor, Canadian Journal of Clinical
Pharmacology (тАЬKiDrug AlertтАЭ), Toronto, Ontario, 2009-2010.
The Division has an active three-year academic fellowship
program. The Royal College of Physicians and Surgeons has
Freedman SB: Runner-up, Pediatric Emergency Research
fully accredited our fellowship program. In addition, we have
Canada - Annual Terry Klassen Young Investigator Award, 2010.
a number of clinical departmental fellows from around the
world spending a year or more with us, further developing their
Freedman SB: Research Recognition Award, Division of
paediatric emergency medicine knowledge and skills. We have
Paediatric Emergency Medicine, The Hospital for Sick Children,
also worked with the Canadian Armed Forces to provide
in recognition of excellence in outstanding effort and
paediatric training to their physician assistants. The division
contribution to research, 2009-2010.
continues to run Paediatric Life Support Courses (PALS and
APLS). In addition, we provide sedation courses and paediatric
Jarvis A: Clinical Inter-professional Collaboration and Education
trauma courses to both internal and external audiences. Staff
Award, Michener Institute of Applied Health Sciences, PALS
travelled to Halifax to teach sedation to the PEM staff at IWK
Advisory Team (Chairperson), 2009.
ChildrenтАЩs Hospital. We also have a well developed weekly
half-day of educational activities for trainees and all health
Jarvis A: Continuing Education Award for Sustained Excellence
care providers in the ED. In the fall, the Division will present
and Contribution, Department of Paediatrics, University of
the seventh annual Paediatric Emergency Medicine Update,
Toronto, 2010.
which in the past six years has been an overwhelming success.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Sudhir DтАЩSouza
Anh Do
Janine Flanagan
John Freedman
Claudio Fregonas
Sabine George
Cara Gilman
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Peter Glazer
Donna Goldenberg
Massoud Grouhi
Shuja Hafiz
Mark Handley-Derry
Leah Harrington
Nicole Inch
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Edward Jin
Eddy Lau
Yen Le
Patricia Linders
Steven Moss
Patricia Neelands
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Carole OтАЩBeirne
Linda Pedder
Christina Ricks
Jennifer Riley
Lillian Rojnica
Domenick Shelton
Dr. Heshy Sturm
Dr. Rahim Valani
Dr. Charmaine Van Schaik
Dr. Jeff Weisbrot
Dr. Sheldon Wise
Dr. Hirotaka Yamashiro
Jarvis A: Co-recipient, Faculty of Medicine 8T9 Medical Alumni
Ratnapalan S: Runner up, Clinical Recognition Award, Division
Association Award, University of Toronto, 2010.
of Emergency Medicine, The Hospital for Sick Children, 2009.
Jarvis A: Michel Weber Education Award for Sustained
Schneeweiss S: Winner, Clinical Recognition Award, Division
Contribution to Paediatric Education in Canada, Canadian
of Paediatric Emergency Medicine, The Hospital for Sick
Paediatric Society, 2010.
Children, 2009.
Jarvis A: First Recipient, Paediatric Emergency Section
Schuh S: Division of Paediatric Emergency Medicine, The
Education Award, Canadian Paediatraic Society, Award was
Hospital for Sick Children, Research Recognition Award тАУ MD,
created and named in Dr. JarvisтАЩ honour for sustained
Runner-up, in recognition of excellence in outstanding effort
contribution to education in the subspecialty, 2010.
and contribution to research 2009-2010.
Jarvis A: University of Toronto Medical Society created an
Publications
annual prize in Dr. JarvisтАЩ name in honour of her contribution as
Al-Farsi S, Oliva M, Davidson R, Richardson SE, Ratnapalan S:
Associate Dean, Health Professions Student Affairs, Faculty of
Periurethral cleaning prior to urinary catheterization in children:
Medicine, for students who demonstrate outstanding qualities
sterile water versus 10% povidone-iodine. Clinical Pediatrics
of caring and support offered to their peers, 2009.
2009: 48(6): pp 656-660.
Lalani A: Best presentation, James C. Fallis Teaching Award for
American Academy of Pediatrics Committee on Pediatric
Paediatric Emergency Medicine Fellows Rounds, The Hospital
Emergency Medicine, American College of Emergency
for Sick Children, 2009-2010.
Physicians Pediatric Committee, Emergency Nurses
Association Pediatric Committee: Joint Policy Statement -
Mehta S: Runner-up, James C. Fallis Teaching Award for Pediatric
Guidelines for care of children in the Emergency Department.
Emergency Medicine Staff Physician Presentation 2010.
Annals of Emergency Medicine 2009: 54: pp 543-552.
Pirie J: Runner-Up, Clinical Teaching Award, Division of Pediatric
American Academy of Pediatrics Committee on Pediatric
Emergency Medicine, The Hospital for Sick Children, 2010.
Emergency Medicine and Council on Clinical Information
Technology, American College of Emergency Physicians
Thull-Freedman J: Co-Recipient, Families as Partners in Patient
Safety Award, 2010.
Pediatric Emergency Medicine Committee: Policy Statement
- Emergency information forms and emergency preparedness
for children with special health care needs. Pediatrics 2010:
Thull-Freedman J: Runner-up, SickKids Emergency Department
125(4): pp 829-837.
Citizenship and Advocacy Award, 2010.
Boutis K, Narayanan U, Dong F, McKenzie H, Yan H, Chew D,
Babyn P: Magnetic resonance imaging of clinically diagnosed
distal fibular Salter-Harris I fractures. Injury 2010: 41(8):
pp 852-856.
Cross-Appointees
Dr. Eyal Cohen
Dr. Astrid Guttmann
Dr. Ronik Kanani
Dr. Christoph Licht
Dr. Jonathan Tolkin
Dr. Hilary Whyte
Dr. Jamie Hutchison
Clinical Fellows
Dr. Amir Ahmad
Dr. Samim Al-Qadhi
Dr.
Dr.
Dr.
Dr.
Dr.
Abdullah Altamimi
Sirisha Boddu
Nadya Godovitch
Maria Oliva
Charles Stewart
Dr. Oren Tavor
Dr. Snehal Vala
Dr. Klaus Werner
Academic Fellows
Dr. Nahar Al- Ruwaili
Dr. Faisal Ahmed Al-Ghamdi
Dr. Fatoumah Alabdulrazzaq
Dr. Ahmed Al-Saleh
Boutis K, Constantine E, Schuh S, Pecaric M, Stephens D,
Chung S, Lim R, Goldman RD: Intranasal fentanyl versus
Narayanan U: Pediatric emergency physician opinions on ankle
placebo for pain in children during catheterization for voiding
clinical decision rules. Academic Emergency Medicine 2010:
cystourethrography. Pediatric Radiology 2010: 40(7):
17(7): pp 709-717.
pp 1236-1240.
Boutis K: Pediatric fractures managed with minimal intervention.
Dubnov-Raz G, Koren G, Finkelstein Y: Selective serotonin
Pediatric Emergency Care 2010: 26(2): pp 152-157.
reuptake inhibitor exposure in pregnancy and neonatal adverse
Boutis K, Seeto B, Pecaric M, Pusic M: Using signal detection
164(4): p 394.
events. Archives of Pediatrics & Adolescent Medicine 2010:
theory to model changes in longitudinal learning of radiological
image interpretation. Advances in Health Sciences Education:
Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P,
Theory and Practice 2010: February 26 [Epub ahead of print].
Dubnov-Raz G, Pollak U, Koren G, Bentur Y: Colchicine
poisoning: The dark side of an ancient drug. Clinical
Boutis K, Schuh S: Prospective validation and head-tohead
Toxicology 2010: 48(5): pp 407-414.
comparison of 3 ankle rules in a pediatric population. Annals
of Emergency Medicine 2010: 55(4): pp 391-392.
Finkelstein Y, Bournissen FG, Hutson JR, Shannon M:
Polymorphism of the ADRB2 gene and response to inhaled
Brown SC, Hart G, Chastain DP, Schneeweiss S, Mcgrath PA:
beta- agonists in children with asthma: A meta-analysis.
Reducing distress for children during invasive procedures:
Journal of Asthma 2009: 46(9): pp 900-905.
randomized clinical trial of effectiveness of the PediSedate┬о.
Finkelstein Y, Garcia-Bournissen F, Hutson JR, Shannon M:
Pediatric Anesthesia 2009: 19(8): pp 725-731.
Polymorphism of the ADRB gene and response toinhaled beta
Chan K: Value of vaccination: The importance of herd effects
agonists in children with asthma: a meta-analysis. Clinical
for pneumococcal conjugate vaccination in Canada. pneumoADIP,
Pharmacology and Therapeutics 2010: 87(Suppl. 1): p S4.
Global Alliance for Vaccine and Immunizations, 2009.
Finkelstein Y, Koren G, Moretti ME, Erebara A, Schechter T,
Chirnomas D, Smith AL, Braunstein J, Finkelstein Y, Pereira L,
Einarson A: Pregnancy outcome following high-dose
Bergmann AK, Grant FD, Paley C, Shannon M, Neufeld EJ:
methotrexate for misdiagnosed ectopic pregnancies: A case
Deferasirox pharmacokinetics in patients with adequate versus
series. Birth Defects Research Part A - Clinical and Molecular
inadequate response. Blood 2009: 114(19): pp 4009-4013.
Teratology 2009: 5: p 494.
Chung S, Forte V, Freedman SB: A review of pediatric foreign
Finkelstein Y, Schechter T, Freedman SB: Surgical masks
body ingestion and management. Clinical Pediatric Emergency
vs N95 respirators for preventing influenza. Journal of the
Medicine 2010: 11(3): pp 225-230.
American Medical Association 2010: 303(10): p 938.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Alawi Baaboud
Vered Gazit
Miguel Glatstein
April Kam
Melissa Parker
Tania Principi
Ayelet Rimon-Babad
Administrative Staff
Deborah Atchison
Sabrina Dubeau
Dana Doll
Crystal Garneau
Ritsa Iriotakis
Sandra Miller
Patricia Nedanovski
Traci Peggie
Majda Savaglio
Pauline Smith
Maggie Stevanovic
Freedman SB: Forensic aspects of paediatric fractures:
Glatstein MM, Garcia-Bournissen F, Giglio N, Finkelstein Y,
Differentiating accidental trauma from child abuse. Journal of
Koren G: Pharmacologic treatment of hyperthyroidism during
the American Medical Association 2010: 304(9): pp 1015-1016.
lactation. Canadian Family Physician 2009: 55(8): pp 797-798.
Freedman SB: Pediatric gastrointestinal emergencies. Clinical
Goldman RD, Scolnik D, Chauvin-Kimoff, L, Farion KJ, Ali S,
Pediatric Emergency Medicine 2010: 11(3): pp 151-152.
Lynch T, Gouin S, Osmond MH, Johnson DW, Klassen TP:
Practice variations in the treatment of febrile infants among
Freedman SB, Al-Harthy N, Thull-Freedman JD: The crying
pediatric emergency physicians. Pediatrics 2009: 124:
infant: Diagnostic testing and frequency of serious underlying
pp 439-445.
disease. Pediatrics 2009: 123(3): pp 841-848.
Glatstein M, Scolnik D, Garcia-Bournissen F, Koren G,
Freedman, SB, Cho D, Boutis K, Stephens D, Schuh S:
Finkelstein Y: T D M Grand Rounds: Hypoglycemia in a healthy
A Palatability of Oral Rehydration Solutions (PORS) study.
toddler. Therapeutic Drug Monitoring 2009: 31(2): pp 173-177.
Archives of Pediatrics & Adolescent Medicine 2010: 164(8):
pp 696-702.
Kam A, Leal J, Freedman SB: Pediatric cellulitis: Success of
emergency department short course intravenous antibiotics.
Freedman SB, Eltorky M, Gorelick M, and the PERC
Pediatric Emergency Care 2010: 26(3): pp 171-176.
Gastroenteritis Study Group: Evaluation of a gastroenteritis
severity score for use in an outpatient setting. Pediatrics 2010:
125: pp e1278-e1285.
Kovesi T, Schuh S, Spier S, Berub├й D, Carr S, Watson W,
McIvor RA: Achieving control of asthma in preschoolers.
Canadian Medical Association Journal 2010: 182(4):
Freedman SB, Powell EC, Nava-Ocampo AA, Finkelstein Y:
pp 365-373.
Ondansetron dosing in infants and children with acute
gastroenteritis: A prospective pharmacodynamic study. Clinical
Lacasse M, Ratnapalan S: Teaching-skills training programs
Pharmacology and Therapeutics 2010: 87(Suppl1): p S69.
for family medicine residents: Systematic review of formats,
content, and effects of existing programs. Canadian Family
Glatstein M, Finkelstein Y, Scolnik D: Accidental methadone
Physician 2009: 55(9): pp 902-903.
ingestion in an infant - case report and review of the literature.
Pediatric Emergency Care 2009: 25(2): pp 109-111.
Lacasse M, RouthierG, LeBlanc P, Th├йor├кt J, Glenn J,
Glatstein M, GarciaтАУBournissen F, Scolnik D, Finkelstein Y,
directors and trainees agree on format and content? Canadian
Koren G: Sulfonylurea Intoxication at a Tertiary Care Paediatric
Medical Education Journal 2010: 1(1): pp e18-e28.
Ratnapalan S: Teaching residents to teach: Do program
Hospital. Canadian Journal of Clinical Pharmacology. Canadian
Journal of Clinical Pharmacology 2010: 17(1): pp e51-e56.
Lee CY, Ratnapalan S, Thompson M, Nathan PC, Closs J,
French A, Punnett A, Garcia-Bournissen F, Ito S, Koren G:
Unusual 4eactions to 5-HT3 receptor antagonists in a child
with rhabdomyosarcoma. Canadian Journal of Clinical
Pharmacology 2010: 17(1): pp e1-e4
164
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
McGuire J, Boutis K, Laupacis A, Parkin P. Should this head
Ratnapalan S: A critical review of probiotic effects on cold
injured child receive a head CT?: A systematic review of clinical
and influenza-like symptom incidence and duration in children.
prediction rules. Pediatrics 2009: 124(1): pp e145-e154.
Canadian Journal of Clinical Pharmacology 2009: 16(3):
pp e441-e442.
Mehta SV, Al-Dhafian A, Schneeweiss S, Babyn P, Pirie J: Does
online X-ray education help trainees in the pediatric emergency
Ratnapalan S: Mentoring in medicine. Canadian Family
department? Open Medicine 2009; 3(3 Suppl.): p 57.
Physician 2010: 56(2): p 198.
Nussinovitch M, Finkelstein Y, Elishkevitz KP, Volovitz B,
Ratnapalan S, Rayar MS, M Crawley M: Educational services
Harel D, Klinger G, Razon Y Nussinovitch U, Nussinovitch N:
for hospitalized children. Paediatrics & Child Health 2009:
Cerebrospinal fluid lactate dehydrogenase isoenzymes in
14(7): pp 433-443.
children with bacterial and aseptic meningitis. Translational
Research 2009: 154(4): pp 214-218.
Ravichandiran N, Schuh S, Bejuk M, Shouldice M, Al-Harthy N,
Au H, Boutis K: Delayed identification of abuse related
Nurmohamed L, Garcia-Bournissen F, Buono R, Shannon MW,
fractures. Pediatrics 2010: 125(1): pp 60-66.
Finkelstein Y: Predisposition to epilepsy- does the ABCB1 gene
play a role? Epilepsia 2010: May 14 [Epub ahead of print].
Rimon A, Daneman A, Gerstle JT, Ratnapalan S: Omental
Infarction in children. Journal of Pediatrics 2009: 155(3):
Nussinovitch U, Finkelstein Y, Harel D, Nussinovitch N,
pp 427-431.
Nussinovitch M: Pattern of cerebrospinal fluid lactic
dehydrogenase during treatment of bacterial meningitis.
Rimon A, Freedman SB: Recent advances in the treatment of
Pediatric Neurology 2010: 42(6): pp 413-416.
acute gastroenteritis. Clinical Pediatric Emergency Medicine
2010: 11(3): pp 163-170.
Osmond MH, Klassen TP, Wells GA, Correll R, Jarvis DA,
Joubert G, Bailey B, Chauvin-Kimoff L, Pusic M, McConnell D,
Schechter T, McCarhty C, Finkelstein Y, Doyle J, Dupuis Lee L:
Nijssen-Jordon C, Silver N, Taylor B, Stiell IG: CATCH: A clinical
Dismal response to high-dose methylprednisolone after failure
decision rule for the use of computed tomography in children
to respond to standard dose in patients with acute GVHD. Bone
with minor head injury. Canadian Medical Association Journal
Marrow Transplantation 2010: March 8 [Epub ahead of print]
2010: 182(4): pp 341-348.
Schuh S, Willan A, Stephens D, Dick P, Coates A: Can
Parker M, Allen U, Stephens D, Lalani A, Schuh S: Predictors
montelukast shorten prednisolone therapy in children with mild
of major intervention in infants with bronchiolitis. Pediatric
to moderate acute asthma? тАУ A randomized controlled trial.
Pulmonology 2009: 44(4): pp 358-363.
Journal of Pediatrics 2009: 155(6): pp 795-800.
Podbielski DW, Surkont M, Tehrani NN, Ratnapalan S: Pediatric
Scolnik D: Fever: A return to basics! Indian Pediatrics 2009:
eye injuries in a Canadian emergency department. Canadian
46: pp 124-125.
Journal of Ophthalmology 2009: 44(5): pp 519-522.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 165
Scott S, Osmond MH, OтАЩLeary K, Graham I, Grimshaw J,
Funding
Klassen TP, and the PERC Spacer Study Group, including
A feasibility study examining referral to community-based youth
Schuh S: Barriers and supports to implementation of MDI/
violence interventions for youth injured by violence. Snider C,
spacer use in nine Canadian pediatric emergency departments:
Nathens A, McElroy R, Lee J, Komar L, Chan T, Rubenfeld G,
a qualitative study. Implementation Science 2009: 4: p 65.
Momdani M, Banfield J, Thorpe K. Canadian Institutes of
Valani R, Sriharan A, Scolnik D: Designing international health
Grant ($100,000 2010)
Health Primary and Community-Based Healthcare Catalyst
electives using the CanMEDS core competencies. Medical
Teacher 2009: 31(12): p 1097.
CLARINET Study: International randomized double blind clinical
study evaluating the efficacy and safety of Clopidogrel 0.2mg/
Valani R, Verma M, Sriharan A, Scolnik D: Enabling change
Kg once daily versus placebo in neonates and infants with
in attitudes among medical students during a paediatric
cyanotic congenital heart disease palliated with a systemic-to-
emergency medicine elective. Israeli Journal of Emergency
pulmonary artery shunt. Finkelstein Y. Sanofi-Aventis Inc./
Medicine 2009: 9(2): pp 22-29.
Bristol- Myers-Squibb Pharmaceuticals ($4,000 2009-2010)
Yarmolinsky J, Ratnapalan S, Kenny DJ: Variation in urban
EBV re-activation and PTLD in pediatric haemtopoietic-stem-
and rural water fluoride levels in Ontario. Journal of the
cell transplant recipients receiving thymoglobulin. Schechter T,
Canadian Dental Association 2009: 75(10): p 707.
Pollock-BarZiv SM, Gassas A, Dupuis L, Finkelstein Y, Doyle J.
Genzyme Canada ($5,000 2008-2009)
Books and Book Chapters
Boutis K: Pediatric ankle fractures. In: UpToDate
Identification of educational and infrastructural barriers to
(Basow DS, ed.). UpToDate, Waltham, MA, 2010.
prompt antibiotic administration for children with cancer
Boutis K: Pediatric foot fractures тАУ Part I. In: UpToDate
Thull-Freedman J, Dupuis L. C17 ChildrenтАЩs Cancer and
(Basow DS, ed.). UpToDate, Waltham, MA, 2010.
Blood Disorders Research Network Educational Grant
with febrile neutropenia. Gupta S, Punnet A, Robinson L,
($2,400 2009-2010)
Boutis K: Pediatric foot fractures тАУ Part II. In: UpToDate
(Basow DS, ed.). UpToDate, Waltham, MA, 2010.
Is electrolyte maintenance solution administration required in
low-risk children with gastroenteritis? Freedman SB, Boutis K,
Drain P, Huffman S, Pirtle S, Chan K: Caring for the World.
Parkin P, Goia C, Atchison D, Schuh S. PhysiciansтАЩ Services
University of Toronto Press, 2009.
Incorporated Foundation ($169,200 2010-2012)
Lalani A: Tetanus. In: Atlas of Pediatrics in the Tropics and
Isotonic versus hypotonic IV maintenance fluids in children:
Resource-limited Settings (Spector J, Gibson T, eds.).
A randomized controlled trial. Geary D, Freedman SB, Beck C,
Elk Grove Village, IL: American Academy of Pediatrics, 2009.
Freidman JN. PhysiciansтАЩ Services Incorporated Foundation
($46,742 2010-2012)
166
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
IVIG for Stevens-Johnson Syndrome in Children. Finkelstein Y.
New Trials Support (TALENTS) Award Talecris
Biopharmaceuticals ($10,000 2009-2010)
Learning ECG Interpretation Using Deliberate Practice. Pusic M,
Howard N, Boutis K, Pecaric M. Glenda Garvey Teaching
Academy Education Project Grant ($15000, 2010 -2012)
Pharmacokinetics and pharmacodynamics of thymoglobulin
in paediatric hematopoietic stem-cell transplant. SchechterFinkelstein T, Gassas A, Dupuis L, Doyle JJ, Pollock S,
Finkelstein Y. Comprehensive Cancer Centre, The Hospital
for Sick Children ($31,660 2009-2010)
Serum biomarkers and quality of life in children with traumatic
brain injury. Hutchison J, Anderson V, Post M, Boutis K,
Guergeurian AM, Sananes R. Ontario Neurotrauma FoundationVictorian Neurotrauma Initiative Collaborative ($505,527
2010-2012)
The choice of a nebulizer for delivering MgSO4 to pediatric
asthmatic patients in the emergency department. Coates AL,
Leung K, Vecellio L, Schuh S. Paediatric Consultants Grant
($4500 2009-2010)
Understanding the pediatric literature: What statistical and
epidemiological concepts do pediatricians need to know?
Thull-Freedman JD, Al-Ghamdi F, Gautam S, Alamri, W.
Paediatric Consultants Grant ($4,500 2009-2010)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 167
Division Head
Dr. Jeremy Friedman
Full-Time
Dr. Hosanna Au
Dr. Carolyn Beck
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Stacey Bernstein
Catherine Birken
Zia Bismilla
Trey Coffey
Eyal Cohen
Emma Cory
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Astrid Guttmann
Robert Hilliard
Sanjay Mahant
Charlotte Moore
Patricia Parkin
Elena Pope
Dr. Michelle Shouldice
Dr. Susan Tallett
Dr. Michael Weinstein
Dr. Randi Zlotnik Shaul
Major Part-Time
Dr. Mark Feldman
Dr. Saul Greenberg
Dr. Moshe Ipp
Dr. Sheila Jacobson
Division of Paediatric Medicine
Divisional Overview
The Obesity Program received funding through the Ministry of
The Division (comprising General Paediatrics, SCAN and
Health and a tertiary care obesity clinic (STOMP) started in the
Dermatology) continues to play an integral role in the core
fall of 2009 with Dr. Catherine Birken in the Paediatric Medicine
activities of the Department of Paediatrics. Our faculty,
Consultation Clinic. The STOMP team was nominated for a
comprising 18 full-time and eight major part-time physicians,
family-centred care advisory council humanitarian award in 2009.
had a successful and productive academic year in 2009-10.
We welcomed one of our dermatology fellows, Dr Irene
Faculty members continued to excel, advocate and gain
Lara-Corrales, as a major part-time faculty member in the
recognition as leaders in their field. Dr. Robert Hilliard, as
dermatology section. Dr Lara-Corrales, who hails from Costa
President of the Canadian Paediatric Society; Dr. Sanjay
Rica, had a valuable and fruitful fellowship and won a resident/
Mahant, as President of the Hospital Medicine Section, and
fellow award as well as the 2010 Weston Research Award at
Dr. Michelle Shouldice, as President-elect of the CPS Section
the Annual Society for Pediatric Dermatology meeting in the USA.
of Child and Youth Maltreatment. Dr. Moshe Ipp was awarded
the CPS Distinguished Community Paediatrician Award in 2009.
The Paediatric Medicine clinical program remains extremely
Dr. Jeremy Friedman continues as an Associate Editor of the
busy and is the largest in-patient service in the hospital.
Paediatrics & Child Health journal and was appointed chair of
Dr. Carolyn Beck has been appointed Director for In-patient
the CPS Annual Conference Planning Committee. Dr. Patricia
Services and together with Dr. Trey Coffey, who leads the
Parkin was invited to join the Child Health Grant Panel for
Quality Group in our Division, has made a number of changes
Canadian Institute of Health Research (CIHR) and the Canadian
to improve efficiency and the overall quality of care. Our
Task Force on Preventive Health Care. Dr. Astrid Guttmann won
hospitalist group continues to be involved in the development
the Child Health Services Research Interest Group Nemours Award.
of the paediatric hospitalist movement in Canada and the
Career development is active with four faculty involved in
USA with Dr. Sanjay Mahant as President of the CPS
Hospitalist Section and one of eight North American members
post-graduate masterтАЩs level training (two in research methods
of the executive committee of PRIS (Pediatric Research in
and two in education). Members of the Division attended
In-patient Settings).
leadership courses through the APA as well as through the
Department of Paediatrics at the Rotman School of Business.
The divisional Complex Care Program continues to develop
under the leadership of Dr. Eyal Cohen. On the clinical side,
This has been a successful year for research productivity.
a dedicated in-patient complex care team operates six beds
There were more than20 abstracts from the Division at the
and is staffed by a hospitalist with complex care expertise and
annual PAS and CPS meetings, including many platform
a nurse practitioner. The ambulatory arm of the complex care
presentations. Funding from both internal and external
team currently coordinates care for more than 100 of the most
agencies, including a number of CIHR grants was secured.
complex, high-needs patients. The Norman Saunders Complex
TARGet Kids!, which is a collaboration between our PORT group,
Care Initiative funded three research grants in 2009/10 and
community paediatricians and members of the Department of
a third competition will run in the fall of 2010. As part of
Family and Community Medicine group under the leadership of
accreditation for 2010, the initiative was nominated by the
Drs Patricia Parkin, Catherine Birken and Jonathon Maguire,
Hospital as a тАЬleading practiceтАЭ тАУ a noteworthy practice carried
has already shown much promise in starting to address gaps
out by a health services organization, which demonstrates
in knowledge about the prevalence, predictors, outcomes and
innovation and creativity and has a positive impact on services
effective strategies for prevention and early identification of
or outcomes for clients and families.
common problems. In the Dermatology Section, Dr. Elena Pope
continues to excel with many grants and publications, while
Dr. Miriam Weinstein is recognized nationally and
internationally for her popular dermatology lectures.
Dr.
Dr.
Dr.
Dr.
Michael Peer
Adam Rapoport
Miriam Weinstein
Christine Newman
Part-Time
Dr. Tony Barozzino
Dr. Salvatore Cammisuli
Dr. Nhung Ho (Derm)
Dr. Perla Lansang
Dr. Michael Sgro
Dr. Christine Webster
Associate
Dr. Nirit Bernhard
Dr. Paul Kadar
Dr. Ronik Kanani
Dr. Irene Lara-Corrales
Dr. Sanjeev Luthra
Dr.
Dr.
Dr.
Dr.
Dr.
Jonathon Maguire
Ivor Margolis
Yehuda Nofech-Mozes
Daniel Roth
Gary Sibbald
Adjunct
Dr. Peter Azzopardi
Dr. Ranjit Baboolal
Dr. Anna Banerji
Dr. Carolyn Calpin
Dr. Bert Cellupica
Education is an important priority in our Division, with
Friedman J: Harry Bain Award for Excellence in Clinical
Dr. Susan Tallett leading the SickKids Learning Institute
Teaching, Department of Pediatrics, University of Toronto,
and Dr. Stacey Bernstein as Director of the Undergraduate
The Hospital for Sick Children, 2010.
Education Program. Under the leadership of Drs. Parkin and
Shouldice the Fellowship Program continues to grow in leaps
Guttmann A: Nemours Award: Child Health Services Research
and bounds with a total of 21 full and part-time fellows this
Interest Group Nemours Award Committee, 2010.
year. Many faculty members were recognized with teaching
awards including Dr. Stacey Bernstein (Wightman-Berris
Ipp M: Distinguished Community Paediatrician Recipient,
Academy Undergraduate Individual Teaching Award from the
Canadian Paediatric Society, 2010.
University of Toronto), Dr. Mark Feldman (Marvin Gerstein
Award for Part-Timers), and Dr. Jeremy Friedman (Harry Bain
Lara-Corrales I, Pope E: 2010 Weston Research Award: Vitamin
Award for Excellence in Clinical Teaching).
D Deficiency in Pediatric Patients with Atopic Dermatitis and
Psoriasis: Prevalence and Risk Factors. Society for Pediatric
Congratulations to Drs. Astrid Guttman, Michael Weinstein and
Dermatology, 2010.
Stacey Bernstein on their promotion to Associate Professor.
Lara-Corrales I, Pope E: Resident/Fellow Award: Eczema
Honours and Awards
Herpeticum in the Paediatric Population. Society for Pediatric
Bernstein S: Wightman-Berris Academy Undergraduate
Dermatology 36th Annual Meeting, Portland, 2010.
Individual Teaching Award, University of Toronto, 2010.
Rapoport A: Scholarship: The Program in Palliative Care
Birken C: STOMP Team Nominated for Family Centered Care
Education and Practice - Pediatric Track. The Harvard Medical
Advisory Council Humanitarian Award, 2009.
School, Boston, MA USA, scholarship to attend program, 2010.
Coffey M, Tallett S, Thomson K, Matlow A: Best Poster
Wasserman JD, Pope E, Balma-Mena A, Mahant S, Carcao M
Award: Knowledge and attitudes of paediatric residents
and Perlman K: Second Place, Poster Award: тАЬCase Report:
regarding communication around medical errors: The
Challenges in Management of Consumptive Hypothyroidism
importance of social context. Canadian Patient Safety
in an Infant with Diffuse Hepatic HemangiomataтАЭ. American
Symposium, Montreal, 2009.
Association of Clinical Endocrinologists Annual Meeting, 2010.
Feldman M: Marvin Gerstein Teaching Award, 2009-2010.
Weinstein, Miriam: Dr. Arthur A. Birt Memorial Lecturer, Invited
Speaker, ChildrenтАЩs Hospital of Manitoba, Department of
Pediatrics & Child Health, 2009.
Feldman M: Barry Zimmerman Memorial Prize 2009
[Continuing Education - for dedicated work on behalf of children
Publications
for the Electronic Child Health Record of Ontario], 2009.
Aimone A, Rovet J, Ward W, Jefferies A, Campbell DM, Asztalos
Feldman M: Best Clinical Teacher Award, Paediatrics, St.
E, Feldman M, Vaughan J, Westall C, Whyte H, OтАЩConnor DL,
JosephтАЩs Health Centre, Toronto, 2009.
on Behalf of the Post-Discharge Feeding Study Group: Growth
and body composition of human milk-fed premature infants
provided with extra energy and nutrients early after hospital
discharge: One year follow-up. Journal of Pediatric
Gastroenterology and Nutrition 2009: 49(4): pp 456-466.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Patricia Colangelo
Carlos E. Contreras
Hilary de Veber
Paul Dick
Suhid (Tony) DтАЩSouza
Claudio Fregonas
Gerald Friedman
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Marvin H. Gans
Hartley A. Garfield
Morton Goldbach
Leslie Goodis
Stuart Gordner
Michelle Gordon
Masoud Grouhi
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
James D. Hilton
Tommy Ho
Alan P. Hudak
Anthony Y.T. Hui
Edward G. Jin
Beverley Kupfert
Eddy Lau
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Cinda B.S. Lee
Maurice Levy
Aubrey Maze
Anilkumar Menon
Saba Merchant
Steven Moss
Larry B. Pancer
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
John Philpott
S. Joseph Porepa
Vladimir Pucholt
Percy Rajchgot
Harkamal Randhawa
Rahul Saxena
Al-Sahab B, Lanes A, Feldman M, Tamim H: Prevalence and
Bollegala N, Garfield H, Scott IM, Wright BJ, Brenneis FR,
predictors of 6-month exclusive breastfinding among Canadian
Atenafu E, Feldman M: The clerkship pediatric rotation: Does
women: A national survey. BMC Pediatrics 2010: 10: p 20.
setting matter? Canadian Medical Education Journal 2010:
1(1): pp 51-55.
Arkachaisri T, Vilaiyuk S, Li S, OтАЩNeil KM, Pope E, Higgins GC,
Punaro M, Rabinovitch EC, Rosenkranz M, Kietz DA, Rosen P,
Chakkittakandiyil A, Pope E: Topical timolol gel for infantile
Spalding SJ, Hennon TR, Torok KS, Cassidy E, Medsger Jr TA:
hemangiomas - A pilot study. Archives of Dermatology 2010:
Localized Scleroderma Clinical and Ultrasound Study Group:
146(5): pp 564-565.
The localized scleroderma skin severity index (LoSSI) and
physician global assessment of disease activity: A work-in-
Chambers CT, Taddio A, Uman LS, McMurtry CM, Appleton M,
progress toward the development of localized scleroderma
Ipp M: Psychological interventions for reducing pain and
outcome measures. Journal of Rheumatology 2009: 36(12):
distress during routine childhood immunizations: A systematic
pp 2819-2829.
review. Clinical Therapeutics 2009: 31: pp 77-103.
Bailey B, Gravelle J, Goldman R, Friedman JN, Parkin P:
Cheng WS, AlSaffar H, Weinstein M, Kitai I: Sporotrichoid-like
External validation of the clinical dehydration scale for children
tuberculosis. Pediatric Infectious Diseases 2009: 28(12):
with acute gastroenteritis. Academic Emergency Medicine
pp 1135-1136.
2010: 17: pp 583-588.
Coffey M, Mack L, Streitenberger K, Bishara T, De Faveri L,
Balma-Mena A, Pope E: Acquired Idiopathic Pterygium Inversum
Matlow A: Prevalence and clinical significance of medication
Unguis. Clinical Pediatrics 2010: 49(4): pp 394-395.
discrepancies at pediatric hospital admission. Academic
Pediatrics 2009: 9(5): pp 360-365.
Barrera M, OтАЩConnor K, Mammone N, Spencer L, Nicholas D,
Jovcevska V, Tallett S, Schneiderman G: Early parental
Cohen E, Friedman JN, Mahant S, Adams S, Jovcevska V,
adjustment and bereavement after childhood cancer death.
Rosenbaum P: The impact of a complex care clinic in a
childrenтАЩs hospital. Child: Care, Health and Development:
Death Studies 2009: 33:6: pp 497-520.
2010: March 9 [Epub ahead of print].
Benchimol EI, Guttmann A, Griffiths AM, Rabeneck L, Mach DR,
Brill H, Howard J, Guan J, To T: Increasing incidence of
Cohen E, Goldman RD, Ragone A, Uleryk E, Atenafu EG,
paediatric inflammatory bowel disease in Ontario, Canada:
Sidiqui U, Mahmoud N, Parkin PC: Child versus adult
Evidence from health administrative data. Gut 2009: 58(11)
randomized controlled trials: A citation analysis of trends,
pp 1490-1497.
1985-2005. Archives of Pediatrics and Adolescent Medicine
2010: 164 (3): pp 283-288.
Bismilla Z, Finan E, McNamara PJ, LeBlanc V, Jefferies A,
Whyte H: Failure of pediatric and neonatal trainees to meet
Feldman ME, Belanger S: Extended release medications for
Canadian Neonatal Resuscitation Program standards for
the treatment of ADHD. Paediatrics & Child Health 2009:
neonatal intubation. Journal of Perinatology 2010: 30(3):
14(9): pp 593-597.
pp 182-187.
Dr.
Dr.
Dr.
Dr.
Dr.
Clive J. Schwartz
David H. Shawn
Angelo Simone
William Gary Smith
Joseph Telch
Dr.
Dr.
Dr.
Dr.
Dr.
Guy Widrich
Peter D. Wong
Hiro Yamishiro
Heather Yang
Ethel Ying
Cross-Appointees
Dr. Glen B. Berall
Dr. Bonnie J. Cameron
Dr. Douglas Campbell
Dr. Gordon J. Donsky
Dr. Katy Driver
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Leona Fishman
Janine Flanagan
John S. Freedman
Lee Ann Gallant
Beth D. Gamulka
Rose Geist
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Sabine R. George
Katerina Haka-Ikse
William B. Hanley
Jaya Islur
D. Anna Jarvis
Ian C. Kitai
Feldman ME, Community Paediatrics Committee of the
Lieberman L, Kirby M, Ozolins L, Mosko J, Friedman JN: Initial
Canadian Paediatric Society: Guidelines for paediatric
presentation of unscreened children with sickle cell disease:
emergency equipment and supplies for a physicianтАЩs office.
the Toronto experience. Pediatric Blood & Cancer 2009: 53(3):
Paediatrics & Child Health 2009: 14(6): pp 402-404.
pp 397-400.
Guttmann A, Cohen E, Moore C: Outcomes-based health
Lo V, Lara-Corrales I, Stuparich A, Pope E: Amniotic membrane
human resource planning for maternal, child and youth health
grafting in epidermolysis bullosa patients with chronic wounds.
care in Canada: A new horizon for the 21st century. Paediatrics
Journal of American Academy of Dermatology 2010: 62(6):
& Child Health 2009: 14(5): pp 310-314.
pp 1038-1044.
Hawkes M, Richardson SE, Ipp M, Schuh S, Adachi D, Tran D:
Lo V, Pope E: Amniotic membrane use in dermatology.
Sensitivity of rapid influenza diagnostic testing for swine-origin
International Journal of Dermatology 2009: 48 (9): pp 935-940.
2009 a (H1N1) influenza virus in children. Pediatrics 2010:
Maguire JL, Birken CS, Jacobson S, Peer M, Taylor C,
125: pp 639-644.
Khambalia A, Mekky M, Thorpe K, Parkin PC: Office based
Lara-Corrales I, Arbuckle A, Zarinehbaf S, Pope E: Principles of
intervention to reduce bottle use in toddlers: A TARGet
wound care in patients with epidermolysis bullosa. Pediatric
Kids! pragmatic randomized trial. Pediatrics 2010: 126(2):
Dermatology 2010: 27(3): pp 229-237.
pp e343-e350.
Lara-Corrales I, Mellerio JE, Martinez AE, Green A, Lucky AW,
Maguire JL, Boutis K, Laupacis A, Parkin PC: Should this head
Azizkhan RG, Murrell DF, Agero AL, Kantor PF, Pope E:
injured child receive a head CT?: A systematic review of clinical
Dilated cardiomyopathy in epidermolysis bullosa.
prediction rules. Pediatrics 2009: 124: pp e145-e154.
A retrospective, multicenter study. Pediatric Dermatology
Mahant S, Cohen E, Weinstein M, Wadha A: Interventions for
2010: 27(3): pp 238-243.
the treatment of pleural empyema in children: A systematic
Lara-Corrales I, Pope E: Dilated cardiomyopathy in
review of randomized controlled trials. Archives of Pediatrics
epidermolysis bullosa. Dermatology Clinics 2010: 28(2):
and Adolescent Medicine 2010: 164: pp 201-203.
pp 347-351.
Mahant S, Cohen E, Weinstein M, Wadhwa A: Video assisted
Lara-Corrales I, Pope E: Autoimmune blistering diseases in
thorascopic surgery versus chest drain with fibrinolytics for the
children. Seminars in Cutaneous Medicine and Surgery 2010:
treatment of pleural empyema in children: A systematic review
of randomized controlled trials. Archives of Pediatrics and
29(2): pp 85-91.
Adolescent Medicine 2010: 164: pp 201-203.
Lara-Corrales I, Somers GR, Ho N: Verrucous Hemangioma:
A challenging vascular lesion. Journal of Cutaneous Medicine
Mahant S, Friedman JN, Connolly B, Goia C, Macarthur C:
and Surgery 2010: 14(3): pp 144-146.
Tube feeding and quality of life in children with severe
neurologic impairment. Archives of Disease in Childhood
Li P, Guttmann A: Recent innovations to improve asthma
2009: 9: pp 668-673.
outcomes in vulnerable children. Research review.
Current Opinion in Pediatrics 2010: 22: pp 783-788.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Howard M. Langer
Leo Levin
Patricia M. Linders
John S. Lovering
Gilbert Miller
John D.M. Murray
Jay D. Rosenfield
Dr. Suzanne Schuh
Dr. Jeffrey J. Weisbrot
Dr. Sheldon A. Wise
Honorary
Dr. Lionel B.H. Boxall
Dr. Andrew Chlebus
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
William Davidson
Till A. Davy
James Dorey
Andrew D. Duic
Anthony S.R. Duke
Robert Farber
Michelle Farine
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Hyder H. Fazal
William Feldman
Adelaide L. Fleming
Raphael Folman
Marvin Gans
Dirk W. Huyer
Martin H. Kosoy
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Michael Lester
David C. Maresky
Marcellina Mian
Janette A. Milne
Paul Munk
Jack Newman
Raymond C.W. Ng
Mahant S, Mekky M, Parkin P. Integrating hospitalists in the
Parkin PC, Macarthur C, Khambalia A, Goldman RD, Friedman
academic health science center: Practice and perceptions in
JN: Clinical and laboratory assessment of dehydration severity
a Canadian center. Journal of Hospital Medicine 2010: 5:
in children with acute gastroenteritis. Clinical Pediatrics 2010:
pp 228-233.
49(3): pp 235-239.
Matlow A, Moody L, Laxer R, Stevens P, Goia C, Friedman JN:
Parkin PC, Maguire JL: Comment: Clinically important head
Disclosure of medical error to parents and pediatric patients.
injuries after head trauma in children. The Lancet 2009: 374:
Archives of Disease in Childhood 2010: 95(4): pp 286-290.
pp 1127-1129.
Mekky M, Jasuja M, Parkin PC: Moderate and severe microcytic
Pope E, Weitzman S, Ngan B, Walsh S, Morel K, Williams J,
anemia in the emergency department: Indicators of care.
Stein S, Garzon M, Knobler E, Lieber C, Turchan K, Wargon O,
Clinical Pediatrics 2009 Nov: 48: pp 902-903.
Tsuchiya A: Mycosis fungoides in the pediatric population:
Report from an international childhood registry of cutaneous
Metry D, Garzon M, Drolet B, Frommelt P, Haggstrom A, Hall J,
lymphoma. Journal of Cutaneous Medicine and Surgery 2010:
Hess C, Heyer G, Siegel D, Baselga L, Katowitz W, Moise L,
14(1): pp 1-6.
Mancini A, Maronn M, Phung T, Pope E, Sun G, Frieden IJ:
PHACE Syndrome: Current knowledge, future directions.
Pope E: Epidermolysis bullosa care in Canada. Dermatologic
Pediatric Dermatology 2009: 26 (4): pp 381-383.
Clinics 2010: 28: pp 391-392.
Mukerji A, Sulowski C, Friedman JN, Opavsky A: Salmonella
Rapoport A: Addressing ethical concerns regarding pediatric
poona meningitis and mastitis causing neonatal meningitis.
palliative care research. Archives of Pediatric Adolescent
Pediatric Infectious Disease Journal 2009: 28(12):
Medicine 2009: 163(8): pp 688-691.
pp 1141-1142.
Ravichandiran N, Schuh S, Bejuk M, Al-Harthy N, Shouldice M,
Nakhla M, Daneman D, To T, Paradis G, Guttmann A: Impact
Au H, Boutis K: Delayed identification of pediatric abuse-
of different models of transition to adult care for youth with
related fractures. Pediatrics 2010: 125: pp 60-66.
diabetes: Findings from a universal health care system.
Pediatrics 2009: 124: pp e1134-e1141.
Rea D, Brandsema JF, Armstrong D, Parkin PC, de Veber G,
Nicolin G, Parkin P, Mabbott D, Bartels U, Tabori U, Dondey J,
children with Neurofibromatosis Type 1. Pediatrics 2009: 124:
Huang A, Rutka J, Buncic JR, Bouffet E: Natural history and
pp e476-e483.
MacGregor D, Logan WJ, Askalan R: Cerebral arteriopathy in
outcome of optic pathway gliomas in children. Pediatric Blood
Rogovik A, Friedman JN, Persaud J, Goldman R: Bacterial blood
& Cancer 2009: 53: pp 1231-1237.
cultures in children with sickle cell disease. American Journal
Palmero ML, Pope E, Brophy J: Sporotrichoid aspergillosis in
of Emergency Medicine 2010: 28(4): pp 511-514.
an immunocompromised child: A case report and review of the
literature. Pediatric Dermatology 2009: 26 (5): pp 592-596.
Rogovik A, Li Y, Friedman JN, Goldman R: Admission and length
Parkin PC, Zlotkin S: CPSP Highlights - Why is this
Journal of Emergency Medicine 2009: 27(7): pp 797-801.
of stay due to painful vaso-occlusive crisis in children. American
tachypneic child so pale? Paediatrics & Child Health 2010:
15(3): pp 135-136.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Evangelia Papadouris
Helene A. Richards
Chandrakant P. Shah
Donald Stewart
Peter G. Strachan
Robert E. Sutton
Fellows
Dr. Kawsari Abdullah
Dr. Sara Abed
Dr. Khalid Al Hawsawi
Dr. Ahmed Alhammadi
Dr. Fadiah Al-Khattabi
Dr. Alexandra Balma-Mena
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Elizabeth Berger
Ajith Chakkittakandiyil
Mara Cole
Ceiridwen Davies
Jihan El-Sayed
Claudia Garcia-Gelvez
Bianca Lee
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Patricia Li
Jonathon Maguire
Madhavi Moharir
Dan Sklansky
Gita Wahi
Anne Wormsbecker
Jeanne Zeller
Research Associates/
students
Preeti Aggarwal
Roxana Arias Sala
Kathleen Armstrong
Theresa Beesley
Vikas Bhalla
Ryan C, Price V, John P, Mahant S, Baruchel S, Brandao L,
Taddio A, Ilersich L, Ipp M, Kikuta A, Shah V, and HELPinKIDS
Blanchette V, Pope E, Weinstein M: Kasabach-Merritt
Team: Physical intervention and injection techniques for
phenomenon: a single centre experience. European Journal
reducing injection pain during routine childhood immunization:
of Haematology 2010: 84(2): pp 97-104.
Systematic review of randomized controlled trials and quasi-
Seltz B, Cohen E, Weinstein M: Do children with complex febrile
pp 48-76.
randomized controlled trials. Clinical Therapeutics 2009: 31:
seizures require routine lumbar puncture to exclude bacterial
or herpes simplex virus meningitis/encephalitis? Pediatric
Taddio A, OтАЩBrien L, Ipp M, Stephens D, Goldbach M, Koren G:
Reliability and validity of observer ratings of pain using the
Emergency Care 2009: 25(8): pp 1-4.
visual analogue scale (VAS) in infants undergoing immunization
Seltz LB, Cohen E, Weinstein M: Risk of bacterial or herpes
injections. Pain 2009: 147(1-3): pp 141-146.
simplex virus meningitis/encephalitis in children with complex
febrile seizures. Pediatric Emergency Care 2009: 25(8):
Wang C, Guttmann A, To T, Dick P: Socioeconomic status
pp 494-497.
and health outcomes in infants: How do those with complex
chronic conditions fare? Archives of Pediatrics and Adolescent
Shah V, Taddio A, Rider M, Appleton M, Bortolussi R, Chambers
Medicine 2009: 163(7): pp 608-615.
C, Ipp M: Effectiveness and tolerability of pharmacological and
combined interventions for reducing injection pain during
Books and Book Chapters
routine childhood immunizations: Systematic review and
Beck C, Friedman JN: Parenteral fluid therapy for infants
meta-analyses. Clinical Therapeutics 2009: 31: pp 104-151.
and children. In: ConnтАЩs Current Therapy, 60th Edition
(Rakel RE, Bope ET, eds.). W.B. Saunders Company, Elsevier,
Sugarman J, Pope E, Lo V, Paller AS: Impediments to research
Philadelphia, 2010.
in pediatric dermatology: The results of a survey of the
members of the Society for Pediatric Dermatology. Pediatric
Funding
Dermatology 2010: 27(4): pp 337-340.
A randomized, controlled, multidose, multicentre, adaptive
phase II/III study in infants with proliferating infantile
Szauter KM, Ordas A, Laxer RM, Pope E, Wherrett D, Alman B,
hemangiomas requiring systemic therapy to compare four
Mink M, Boyd CD, Csiszar K, Hinek A: A novel fibrotic disorder
regimens of Propanolol (1 or 3 mg/kg/day for 3 or 6 months)
associated with increased dermal fibroblast proliferation and
to placebo (double blind). Pope E, Chakkittakandiyil A,
down regulation of genes of the microfibrillar network. British
Lara-Corrales I. Pierre Fabre Dermatologie ($373,044
Journal of Dermatology 2010: June 18 [Epub ahead of print].
2010-2012)
Taddio A, Chambers CT, Halperin SA, Ipp M, Lockett D,
A study of the epidemiology of adverse events in children
Rieder MJ, Shah V: Inadequate pain management during
hospitalized in Canada: The Canadian paediatric adverse
routine childhood immunizations: The nerve of it.
events study. Matlow A, Baker R, Flintoft V, Cronin G, Dube R,
Clinical Therapeutics 2009: 31: pp 152-167.
Nijssan-Jordan C, Coffey M, Stevens P. Canadian Patient
Safety Institute/SickKids Foundation/Contributions from
the participating institutions ($550,000 2008-2010)
Hayyah Clairman
Atina Cote
Jessica Danquah
Julie DeGroot
Alessia Dolcetti
Jasmine Eliav
Stephanie Erdle
Amy Glicksman
Raquel Paez Gonzalez
Tara Hahmann
Melanie Kalbfleisch
Lara Katz
Kanthi Kavikondala
Marina Khovratovich
Elliot Lavi
Erica Lee
Grace Lui
Natalie Lui
Radha MacCulloch
Jennifer MacInnis
Tarandeep Malhi
Shaun Mehta
Magda Mekky-Walke
Leah Mirsky
Daria Nowak-Hariasz
David Pirello
Alejandra Ragone
Subitha Rajakumaran
Sudha Raman
Colleen Rooney
Maxine Seider
Nisha Sivagurunathan
Flora Shan
Adrian Tsang
An office based intervention to improve media use in preschool
Collaborative community-based complex care coordination.
children: a randomized controlled trial. Birken CS, Beck CE,
Cohen E, Nicholas D, Spalding K, Narayanan U, Friedman J.
McCrindle B, Parkin PC. Paediatric Consultants Grant ($9,975
Norman Saunders Complex Care Initiative Grant Competition
2006-2009)
($47,450 2009-2011)
Anti-reflux procedures after gastrostomy in children with
Development and evaluation of outcome measures in patients
neurologic impairment: A nested case-control study. Mahant S,
with epidermolysis bullosa. Pope E, Schwieger-Briel A.
Cohen E, Connolly B, Jovcevska V. Norman Saunders Complex
Canadian Dermatology Foundation ($25,000 2009-2010)
Care Initiative-Grant Competition ($13,232 2008-2009)
Development and validation of toddler NutriSTEP. RandalCanadian Institutes of Health Research Charting the territory:
Simpson JA, Keller HH, Beyers JE, Birken CS. Canadian
Determining and documenting trajectories for families where
Institutes of Health Research ($200,809 2010-2012)
a child has a life-threatening condition. Rapoport A, Raiman J,
Weiss S, Cohen E, Siden H, Steele R: Canadian Institutes of
Does complicated pneumonia lead to chronic lung disease?
Health Research ($1,304,676 2008-2013)
Cohen E, Weinstein M, Mahant S, Dell S, Traubici J, Wadha A.
Paediatric Consultants Grant ($9,900 2010-2011)
Severe iron-deficiency anemia in infants and young children:
Canadian Pediatric Surveillance Program. Zlotkin S, Parkin P,
Effectiveness of a new neuromuscular electrical stimulation
McCourt C, Wong S, Grabowski J, Carcao M, Belletrutti M.
(NMES) treatment technique (VitalStim┬о therapy) in the
Canadian Paediatric Society/Public Health Agency of Canada
management of young infants with severe dysphagia. A
(In-kind 2009-2011)
Prospective Pilot Study. Mahant S, Marcus S, Friedman JN:
Paediatric Consultants CPA Grant ($9,080 2010 - 2011)
Career decision-making in paediatric residency. Shouldice M,
Atkinson A. Pediatric Consultants Grant ($4,995 2010)
Enhancing patient safety using web based simulation project.
Glover Takahashi S, Matlow A, Tallett S, Bandiera G, McIlroy J.
CIHR emerging team in childhood obesity research.
Network for Excellence in Simulation for Clinical Teaching
McCrindle B, Parkin P, Pencharz P, Hamilton J, Anderson G,
and Learning ($50,000 2009-2010)
Birken C, Wells G, Riddell M, Hanley A, OтАЩConnor D, Dettmer E,
Bellisimo N, Langer J, Tein I. Canadian Institutes of Health
Research ($2,452,522 2008-2013)
Evaluation of OntarioтАЩs Universal Influenza Immunization
Program. Kwong JC, Guttmann A, Pourbohloul B, Moran MK,
Sander BH, Reynolds DL, Marra F, Krahn M, Stukel TA, Smith M,
Clonality of T Cells in peripheral blood of children with
Halperin J, Alan S, Roos, LL, Upshur, REG, Meyers LA, Garay JR,
cutaneous lymphomas: A cohort pilot study. Pope E, Weitzman S,
Langley JM, Patrick DM, Svenson L, Ross AG, McNeil SA, To T,
Zeller J, Chakkittakandiyil A, Alexander S, Abdelhaleem M,
Dell S, Northrup DA, Parkin P, Bowles SK, Manuel DG. Canadian
Ngan B. Conker Ride Cancer Foundation ($20,000 2010-2015)
Institutes of Health Research ($1,091,729 2006-2009)
Clonality of T cells in peripheral blood of children with
Health outcomes from low vitamin D in toddlers.
cutaneous lymphomas: A cohort pilot study. Pope E, Weitzman S,
Maguire JL. Canadian Institutes of Health Research
Zeller J, Chakkittakandiyil A, Alexander S, Abdelhaleem M,
($680,191 2010-2014)
Ngan B. Division of Haematology/Oncology Leukemia/
Lymphoma Research Fund ($20,000 2010-2015)
Administrative
Support Staff
Tiziana Altobelli
Jackee Colquhoun
Jasmine Hylton
Josie Marcantonio
Daffodil Morrison
Kathryn Robertson
Christina Stevancec
Donna Whitely
HELPinKIDS (Help Eliminate Pain in Kids): Conquering
Nutritional education and the prevention of iron depletion in
immunization pain. Taddio A, Bortolussi B, Chambers C,
children 9 months to 2 years: A randomized controlled trial.
Halperin S, Ipp M, Macdonal N, Meuser A, Midmer D,
Parkin PC, Maguire J, Khambalia A, Jacobson S, Peer M.
Mousmanis P, Palda V, Pillai Ridell R, Rieder M, Rogers J,
Danone Institute ($61,148 2006-2009)
Scott J, Shah V. Canadian Institutes of Health Research
Knowledge Translation Supplement Grant ($38,788 2009-2010)
Palindromy at the NF1 locus as a risk factor for NF1-associated
malignancy. Lewis S, Parkin P. The Hospital for Sick Children
Improving the care of children with chronic and complex health
Research Institute New Ideas Grant Competition ($45,023
needs (CCCHN): Systematic reviews of models of care and
2006-2009)
best practice. Cohen E, Mahant S, Jovcevska V. Paediatric
Consultants Grant ($5,686 2009-2010)
Parental perception of forgoing artificial delivery of nutrition
and hydration during end-of-life care for their children. Rapoport
Innovation fund in childrenтАЩs palliative care research
A, Newman C, Rugg M, Steele R. Norman Saunders Complex
experiences and perceptions of paediatric health professionals
Care Initiative Grant Competition ($11,304 2009-2010)
providing end of life and palliative care. Muskat B, Anthony S,
Beaune L, Brownstone D, Hubley P, Newman C, Rapoport A.
ParentsтАЩ needs around disclosure of adverse events: A
SickKids Social Work Research Endowment Fund and
qualitative study. Coffey M, Matlow A, Friedman J, Espin S.
Innovation Fund in ChildrenтАЩs Palliative Care ($7,000
Canadian Patient Safety Institute ($6,700 2010-2011)
2009-2010)
Partnered learning project. Lingard L, Durrant M, FlemingIs electrolyte maintenance solution administration required in
Carroll B, Lowe M, Nicholas D, Reisman J, Sinclair L, Tallett S.
low-risk children with gastroenteritis? Freedman S, Schuh S,
HealthForceOntario ($413,553 2007-2009)
Parkin P, Boutis K, Goia C, Atchison D. PhysiciansтАЩ Services
Incorporated Foundation ($169,200 2010 - 2012)
Patient-level predictors of adverse events in children: what is
the role of complexity? Coffey M, Cohen E, Matlow A, Flintoft V,
Is prolonged bottle feeding an independent risk factor for
Friedman J, Berry J, Guttman A. Paediatric Consultants
overweight in young children? Birken CS, Parkin PC, OтАЩConnor D,
Partnership/The Hospital for Sick Children ($8,920 2010-2011)
Jacobson S, Peer M, Mekky M. DeanтАЩs Fund New Staff
Competition, Faculty of Medicine, University of Toronto
Patterns and predictors of health care utilization by adult
($9,972 2008-2010)
survivors of childhood cancer: A Pediatric Oncology Group of
Ontario and ICES population database linkage study. Nathan P,
Maintenance intravenous saline study: a randomized, double-
Guttmann A. Canadian Institutes of Health Research
blind controlled trial of 0.9% NaCl/Dextrose 5% vs. 0.45%
($426,000 2009-2011)
NaCl/Dextrose 5% as maintenance intravenous fluids in
hospitalized children. Friedman JN, Freedman S, Beck C,
Pediatric Outcomes Research. Parkin PC, Macarthur C.
Geary D. Paediatric Consultants Grant ($9,956 2007-2009)
SickKids Foundation ($750,000 2008-2013)
Measuring the quality of hospital care for children and youth
Pediatric Research in Inpatient Setting Network, Principal
in Canada. Guttmann A, Matlow A, Moore C, Parshuram C,
Investigator for SickKids site. Srivastava R, Conway P, Keren R,
Stukel T, To T. Canadian Institutes of Health Research
Landrigan C, Mahant S, Shah S, Simon T, Tieder J, Wilson K.
($25,000 2007-2010)
Child Health Corporation of America Grant ($1,300,000
2009-2012)
176
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Pilot study of a lifestyle program in children receiving treatment
THE MASC (Medical and Social Complexity) Screening Tool
for acute lymphoblastic leukemia (ALL). Nathan P, Wright M,
Derivation Study Phase 1 - Tool construction and pilot-testing.
Collins L, Birken CS, Dettmer E. New Ideas Grant Competition,
Maguire JL, Birken CS, Cohen E, Adams S, McNeill, Netton C,
Research Institute, The Hospital for Sick Children ($46,153
Pai N, Parkin PC. Norman Saunders Complex Care Initiative
2008-2010)
Grant Competition ($42,982 2009-2011)
PROMOTE: Preschoolers at risk - obesity and cardiometabolic
The usefulness of comprehensive care plans for children with
risk factors: Towards early identification. Birken CS, Adeli K,
special health care needs. Adams S, Cohen E. Nicholas D,
Hamilton J, Hanley A, Maguire J, McCrindle B, Parkin PC.
Mahant S, Friedman J. Norman Saunders Complex Care
Canadian Institutes of Health Research ($100,000 2010-2011)
Initiative Grant Competition ($21,660 2009-2010)
PROMOTE: Preschoolers at risk - obesity and cardiometabolic
Treatment choices for children with typical acute immune
risk factors: towards early identification. Birken CS, Adeli K,
thrombocytopenic purpura: development of a decision aid.
Hamilton J, Hanley A, Maguire J, McCrindle B, Parkin PC.
Beck C, Birken CS, Blanchette V, Boydell K, Llewellyn-Thomas
PhysiciansтАЩ Services Incorporated Foundation ($168,200
H, Parkin PC. DeanтАЩs Fund New Staff Competition, Faculty of
2010-2012)
Medicine, University of Toronto ($10,000 2006-2011)
Regional migration patterns of children with complex chronic
Vitamin D deficiency in urban Canadian toddlers: A study of
conditions. Cohen E, Guttmann A, Yantzi N. Norman Saunders
prevalence and risk factors. Parkin PC, Maguire J, Mekky M.
Complex Care Initiative Grant Competition ($25,603
Dairy Farmers of Ontario ($90,000 2008-2010)
2009-2010)
Vitamin D deficiency in pediatric patients with atopic
Safer medications for children: Quantifying nephrotoxicity
dermatitis and psoriasis: Prevalence and risk factors. Pope E,
through secondary analysis of electronic data. Parshuram C,
Lara-Corrales I. Canadian Dermatology Foundation ($10,000
Guttmann A. Canadian Institutes of Health Research
2010-2012)
($100,000 2009-2011)
Vitamin D deficiency in pediatric patients with atopic dermatitis
Short and long term outcomes of complicated pediatric
and psoriasis: Prevalence and risk factors. Lara-Corrales I,
pneumonia. Cohen E, Weinstein M, Dell M, Mahant S,
Pope E, Maguire, Parkin P. Weston Research Award, Society
Traubici J, Mekky M. Faculty of Medicine, University of
for Pediatric Dermatology ($20,000 2010-2012)
Toronto ($10,000 2008-2010)
Vitamin D supplementation for preschoolers. Maguire J.
TARGet Kids! Operating Grant. Maguire J. St. MichaelтАЩs
University of Toronto DeanтАЩs Fund ($10,000 2010-2012)
Hospital Foundation ($30,000 2010-2011)
Vitamin D supplementation for preschoolers: A TARGet Kids!
The bedside paediatric early warning system: A cluster RCT of
randomized controlled trial. Maguire JL, Mamdani M, Birken CS,
mortality and processes of care. Parshuram C, Hutchison J,
Parkin P. DeanтАЩs Fund New Staff Competition, University of
Parkin PC, Beyene J, Dryden-Palmer K. Canadian Institutes of
Toronto, Faculty of Medicine ($9,976 2010-2015)
Health Research ($3,959,694 2010-2015)
The CanMeds role of collaborator: How well is it taught and
evaluation from the perspectives of faculty and residents.
Berger E, Tallett S, Chan M, Jenkins D. Department of
Paediatrics ($5,000 2009-2011)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 177
Division Head
Dr. Felix Ratjen
Full-Time
Dr. Allan L. Coates
Dr. Sharon Dell
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Hartmut Grasemann
Indra Narang
Theo Moraes
Melinda Solomon
Padmaja Subbarao
Neil Sweezey
Part-Time
Dr. Peter Bikangaga
Dr. Charlotte Miller
Adjunct Scientist
Dr. Hiran Selvadurai
Cross-Appointees
Dr. T. Douglas Bradley
Dr. Theodore Marras
Dr. Anne Stephenson
Honorary
Dr. Dennis Gurwitz
Dr. Elizabeth Tullis
Division of Respiratory Medicine
Divisional Overview
Dr. Sharon Dell is now Associate Program Director for the
The Division of Respiratory Medicine continues to provide
Clinical Epidemiology & Health Care Research program within
comprehensive care for patients affected by such paediatric
the Faculty of Medicine at the University of Toronto. The
pulmonary diseases as asthma, cystic fibrosis (CF), interstitial
program offers both a masterтАЩs degree and a doctoral-level
lung diseases, primary ciliary dyskinesia (PCD), hereditary
degree and has an international reputation for excellence in
hemorrhagic telangiectasia (HHT), sleep-related breathing
training clinicians in clinical, health services and decision
disorders, complex respiratory care requiring ventilatory
sciences research.
support, as well as children with congenital malformations
involving the respiratory tract. We provide consultation support
Dr. Neil Sweezey leads the HospitalтАЩs Clinician-Scientist
for the Hospital in all areas of paediatric respiratory disease.
Training Program and is the Toronto centre leader and a
The division also provides various diagnostic services including
national executive member of the CIHR-funded Canadian Child
flexible bronchoscopy. Over the last year, we have broadened
Health Clinician Scientist Program. These programs provide
our diagnostic spectrum of tests to assess diseases with
advanced scientific training and mentoring for child health
airway inflammation, including test of nitric oxide in exhaled air,
clinicians preparing for careers as independent researchers in
as well as gas-mixing techniques as more sensitive tests for
child health. There is a broad spectrum of both basic science
obstructive airway diseases. The infant pulmonary function
and clinical research that bridges the laboratory to the clinic in
laboratory offers a unique spectrum of tests that are still not
many disease areas. The major research foci include clinical
available at any other centre in Canada. This has led to the
and epidemiological studies in patients with asthma and CF,
potential for diagnostic tools to objectively assess lung disease
translational studies on airway inflammation and infection in
in infants and young children. The service is available for the
cystic fibrosis, effect of sex hormones in airway inflammation,
assessment of both patients in the Hospital and outpatients.
defining the role of novel genes in lung development, studies in
We are currently in the process of developing pulmonary
aerosol therapy and exercise physiology.
function tests for pre-school children.
Dr. Padmaja Subbarao is Deputy Director of the Canadian
As part of the Toronto Lung Transplantation Program, the
Healthy Infant Longitudinal Development (CHILD) Study, the
division provides pre- and post-transplantation care for children
largest birth cohort in Canadian history. The role of the study is
with end-stage lung disease. The lung transplant program
to elucidate the factors involved in the development of asthma
continues to be the largest in the country. The program is now
and allergies in early childhood; it is supported by CIHR and
open for performing infant lung transplantation in select patients.
AllerGen. Dr. Subbarao is leading this project as a co-Principal
The training program is led by Dr. Melinda Solomon and has
She has also been successful in attracting additional private
independent Royal College of Physicians and Surgeons of
funding for the infant pulmonary function cohort in this study
Investigator with Dr. Malcolm Sears from McMaster University.
Canada accreditation. It is the largest training program for
that will provide the largest study using lung function
paediatric respiratory medicine in the country and provides
measurements in this age group to date. In addition, Dr. Subbarao
the full range of training that is required for Royal College of
has continued to work on pioneering new methods of lung
Physicians and Surgeons of Canada certification. It also
function assessment and inflammatory assessment such as
provides what is required for board certification in paediatric
single breath exhaled nitric oxide and multiple breath washout
pulmonology in the United States and trains physicians from
technology, establishing SickKids as a world leader in infant
abroad. Dr. Solomon recently completed the Education
pulmonary function testing. Dr. Subbarao has also successfully
Scholars Program and is currently pursuing a masterтАЩs degree
received funding for multiple research studies, as well as
of Community Health (Health Professional Teacher Education).
salary support from the CIHR, the Young Investigator Award.
Fellows
Dr. Amal Al-Naimi
Dr. Nasser Al-Harbi
Dr. Guy Tal
Dr. Surendran Thavagnanam
research Fellow
Dr. Amal Al-Naimi
Subspecialty Residents
Dr. Tara Allen
Dr. Suhail Al-Saleh
Dr.
Dr.
Dr.
Dr.
Dr.
Reshma Amin
Glenda Benidak
Tania Samanta
Joanna Massam
Connie Yang
Administrative Staff
Hanadi Attar- Elbard
May Grace-Brydges
Victoria Snell
Thusi Sribavan
The division continues to be involved in the NIH-funded
In addition, members of the division are key partners of the
Childhood Asthma Management Program Continuation Study
team that forms the Cystic Fibrosis Centre, highlighting the
(Dr. Grasemann, Dr. Solomon, Dr. Subbarao). There has also
longstanding and ongoing excellence in both clinical care and
been a growing interest in assessing the pulmonary sequelae
research at SickKids in this area. The CF Centre in co-led by
of sickle cell disease that are currently being addressed in a
Christine Bear, Senior Scientist, Molecular Structure &
number of research studies (Dr. Grasemann, Dr. Narang,
Function, and Dr. Felix Ratjen. Newborn screening for CF was
Dr. Subbarao). Dr. Allan Coates recently retired from the
started last year and the team at SickKids was a major driving
Division of Respiratory Medicine but remains active on both the
force in getting it off the ground. Dr. Ratjen acts as medical
provincial and national level with the Ontario Lung Association
advisor to the screening group in Ottawa, and a collaborative
and the Canadian Thoracic Society, promoting training of
study funded by the Canadian CF Foundation has been initiated
spirometry in children as well acting in advisory roles for research
to evaluate the clinical course of patients with an unclear
studies using lung function testing with Statistics Canada.
diagnosis within the Newborn Screening Program. Dr. Ratjen
and the CF group are involved in multiple studies in a leading
Dr. Dell is involved in an international program to develop a
(PI) role. These include multi-centre studies on azithromycin in
new classification for interstitial lung diseases and a NIH
Pseudomonas negative CF patient, this is the first collaborative
sponsored study on primary ciliary dyskinesia. Dr. Dell, in
study funded by the US CF Foundation conducted in Canada
collaboration with scientists from Health Canada, Environment
and in the US. Along with the study on the role of aspergillus
Canada and Berkeley University, leads a research program
infection in CF patients which is funded by both the Canadian
examining effects of environmental exposures on asthma
CF Foundation and Physician Service Incorporated and the study
outcomes in Toronto school children. She also conducts
on the use of hypertonic saline as an early intervention strategy
multi-centre research in primary ciliary dyskinesia in the NIH
funded by the US CF Foundation and National Institute of Health.
sponsored Genetic Diseases of Mucociliary Clearance
Consortium and in interstitial lung disease with the
Dr. Ratjen is also involved in developing new outcomes
ChildrenтАЩs Interstitial Lung Disease Consortium.
measures in the BREATHE program to assess improvement in
CF lung disease, and a study to develop CFTR corrector therapy
Dr. Theo MoraesтАЩ research is directed towards a better
funded by CIHR and the Canadian CF Foundation. A team grant
understanding of processes driving lung inflammation as well
with Dr. Ratjen as PI has been funded by CIHR bringing together
as immunological mechanisms involved in immunity against
basic scientists, including stem cell researchers with clinical
respiratory viruses. Dr. Indra Narang focuses on clinical and
scientists. Dr. Grasemann is leading a series of studies to
physiological studies related to sleep-disordered breathing
elucidate the role of arginase and NO deficiency in CF lung
and has started a collaboration with numerous services in the
disease; the studies are sponsored by CIHR and the Canadian
institution including studies on obesity and cardiac disorders
CF Foundation. Dr. Sweezey as PI is funded by the Canadian CF
such as cardiomyopathies. Dr. Sweezey, in collaboration with
Foundation to study the effects of sex hormones on airway
Dr. Feige Kaplan at McGill, is studying cellular and molecular
inflammation in CF. Other studies supported by research grants,
aspects of the roles of novel and known glucocorticoid
as well as generous support by individuals such as the Irwin
responsive genes in lung development. Dr. Reshma Amin has
family, are ongoing in addition to industry-sponsored studies
recently joined our Division and brings expertise in both clinical
including an 80-site study in Australia, Canada and the US on
research related to CF lung disease as well as clinical expertise
denufosol, a P2Y receptor agonist that activates chloride
in sleep-related breathing disorders. She will focus her clinical
conductance through alternative chloride channels (PI Dr.
and research activities on technology dependent children.
Ratjen). The CF group is also involved in other clinical studies
of drugs targeting the basic defect in CF. A close collaboration
exists with the adult CF program at St, MichaelтАЩs Hospital led
by Dr.Tullis in both clinical care and many areas of research,
and with the Lung Transplant Team at Toronto General Hospital
led by Dr. Keshavjee.
180
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
For a more complete description of our clinical activities,
Amin R, Dupuis A, Aaron SD, Ratjen F: The effect of chronic
educational events and research interests, please visit our
infection with aspergillus fumigatus on hospitalizations and lung
website at http://www.sickkids.ca/respiratorymedicine/index.
function in cystic fibrosis patients: Chest 2010: 137: pp 1-6.
html as well as the website of the CF Centre http://www.
sickkids.ca/Centres/Cystic-Fibrosis-Centre/index.html.
Amin R, Kwon S, Moayedi Y, Sweezey NB: Pulmonary vein
stenosis: Case report and literature review. Canadian
Honours and Awards
Respiratory Journal 2009: 16: pp e77-e80.
Grasemann H: Zellers Senior Scientist Award, Canadian Cystic
Fibrosis Foundation, 2009.
Amin R, Noone PG, Ratjen F: Chemical pleurodesis versus
surgical intervention for persistent and recurrent
Moraes TJ: Postdoctoral Salary Award, Canadian Child Health
pneumothoraces in cystic fibrosis. Cochrane Database
Clinician Scientist Program, 2009.
of Systematic Reviews 2009: 15(2): CD00748.
Ratjen F: SickKids Foundation H.E. Sellers Chair in Cystic
Amin R, Subbarao P, Jabar A, Balkovec S, Jensen R, Kerrigan S,
Fibrosis, 2009-2010.
Gustaffson P, Ratjen F: Hypertonic saline improves the LCI in
paediatric CF patients with normal lung function. Thorax 2010:
Subbarao P: New Investigator Award in Area of Clinical Research,
65: pp 379-383.
Canadian Institutes of Health Research, 2009.
Barbato A, Bertuola F, Kuehni C, Karppi M, Kotecha S,
Publications
Pijnenburg MW, Ratjen F, Seddon P, Bush A: Paediatrics in Berlin.
Allen U, Barton M, Beyene J, Hu P, Khodai-Booran N, Hebert D,
The European Respiratory Journal 2009: 34(2): pp 436-443.
Dipchand A, Ng V, Solomon M, Grant D, Fecteau A, Ngan B,
Read S, Zielenska M, Weitzman S: Gene expression using
Barton M, Wasfy S, Dipchand A, Hebert D, Ng V, Solomon M,
microarrays in transplant recipients at risk of EBV
Fecteau A, Stephen D, Allen U: Seven-valent pneumococcal
lymphoproliferation after organ transplantation: Preliminary
conjugate vaccine in pediatric solid organ transplant receipients:
proof-of-concept. Paediatric Transplantation 2009: 13:
A prospective study of safety and immunogenicity. Pediatric
pp 990-998.
Infectious Diseases Journal 2009: 28: pp 688-692.
Al-Saleh S, Mei-Zahav M, Faughnan M, MacLusky IB, Carpenter
Belik J, Stevens D, Pan J, Shehnaz D, Ibrahim C, Kantores C,
S, Letarte M, Ratjen F: Screening for pulmonary arteriovenous
Ivanovska J, Grasemann H, Jankov RP: Chronic hypercapnia
malformations in children with hereditary hemorrhagic
downregulates arginase expression and activity and increase
telangiectasia. The European Respiratory Journal 2009:
pulmonary arterial smooth muscle relaxation in the newborn rat.
34(4): pp 875-881.
American Journal of Physiology. Lung Cellular and Molecular
Physiology 2009: 297(4): pp L777-L784.
Al-Saleh S, Riekstins A, Forrest CR, Philips JH, Narang I:
Sleep related disordered breathing in children with syndromic
craniosynostosis. Journal of Cranio-Maxillofacial Surgery 2010:
June 1 [Epub ahead of print].
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 181
Benden C, Faro A, Worley S, Arrigain S, Aurora P, Ballmann M,
Hedlin G, Eber E, Aurora P, Lodrup Carlsen K.C, Ratjen F,
Boyer D, Conrad C, Eichler I, Elidemir O, Goldfarb S, Mallory G,
Dankert-Roelse RI, Turner S, Midulla F, Barraldi E, Bush A:
Mogayzel P, Parakininkas D, Solomon M, Visner G, Sweet SC,
Editorial: Paediatric assembley: Paediatric respiraotry disease:
Danziger-Isakov LA: Minimal acute rejection in pediatric lung
Past, present, and future. The European Respiratory Journal
transplantation тАУ does it matter? Pediatric Transplantation
2010: 36(2): pp 225-228.
2010: 14: pp 534-539.
Heijerman H, Westerman E, Conway S, Touw D, D├╢ring G,
Bendiak G, Ratjen F: The approach to pseudomonas aeruginosa
Consensus Working Group: Inhaled medication and inhalation
in cystic fibrosis Seminars in Respiratory and Critical Care
devices for lung disease in patients with cystic fibrosis: A European
Medicine 2009: 30(5): pp 587-595.
consensus. Journal of Cystic Fibrosis 2009: 8(5): pp 295-315.
Brand PL, Ratjen F, Aurora P, Dankert-Roelse JE, Ross-Russell RI,
Hugle B, Solomon M, Harvey E, James A, Wadhwa A, Amin R,
Kuehni CE, Midulla F, Hedlin G: Scientific assembly update.
Bell-Peter A, Benseler S: Pneumocystis jirovecii pneumonia
Paediatrics in Vienna. The European Respiratory Journal 2010:
following Rituximab treatment in WegenerтАЩs Granulomatosis.
35(5):1172-1178.
Arthritis Care & Research 2010: June 25 [Epub ahead of print].
Chiaw K, Huan LJ, Gagnon S, Ly D, Sweezey NB, Rotin D, Deber
Lan J, Ribeiro L, Mandeville I, Nadeau K, Bao T, Cornejo S,
CM, Bear CE: Functional rescue of DeltaF508-CFTR by peptides
Sweezey NB, Kaplan F: Inflammatory cytokines, goblet cell
designed to mimic sorting motifs. Chemistry and Biology 2009:
hyperplasia and altered lung mechanics in Lgl1+/- mice.
16: pp 520-530.
Respiratory Research 2009: 10: p 83.
Dell SD, Foty RG, Stieb D, To T, Walter SD, Gilbert N: Asthma
Larry L, Tanswell K, Laberge S, McCusker C, Ratjen F: Pediatric
and allergic disease prevalence in a diverse sample of Toronto
respiratory assembly. Mini symposium on lung inflammation.
school children: Results from the T-CHEQ Study. Canadian
Canadian Respiratory Journal 2010: 17(2): pp 35-41.
Respiratory Journal 2010: 17: pp e1-6.
Lougheed MD, Lemiere C, Dell SD, Ducharme FM, FitzGerald JM,
Douda DN, Farmakovski N, Dell SD, Grasemann H, Palaniyar N:
Leigh R, Licskai C, Rowe BH, Bowie D, Becker A, Boulet LP,
SP-D counteracts GM-CSF-mediated increase of granuloma
Canadian Thoracic Society Asthma Management Continuum:
formation by alveolar macrophages in lysinuric protein
2009 Consensus Summary for children 6 years and over and
intolerance. Orphanet Journal of Rare Diseases 2009: 23: p 29.
adults. Canadian Respiratory Journal 2010: 17: pp 15-24.
Grasemann H, Ratjen F: Editorial: Leukocyte trafficking and
Lougheed MD, Lemiere C, Dell SD, Ducharme FM, FitzGerald JM,
matrix metalloproteinase-8 in obliterative bronchioliti. Journal
Leigh R, Licskai C, Rowe BH, Bowie D, Becker A, Boulet LP,
of Leukocyte Biology 2010: 87(1): pp 23-24
Canadian Thoracic Society Asthma Committee: Commentary on
long-acting beta-2 agonist use for asthma in Canada. Canadian
Respiratory Journal 2010: 17: pp 57-58.
182
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Manwani N, Gagnon S, Post M, Joza S, Muglia L, Cornejo S,
Nashed A, Al-Saleh S, Gibbons J, MacLusky I, MacFarlane J,
Kaplan F, Sweezey NB: Reduced viability of mice with lung
Riekstins A, Clarke J, Narang I: Sleep related breathing in
epithelial-specific knockout of glucocorticoid receptor. American
children with mucopolysaccharidosis. Jounal of Inherited
Journal of Respiratory Cell and Molecular Biology 2009:
Metabolic Disease 2009: 32: pp 544-550.
December 30 [Epub ahead of print].
Navratil T, Evans C, Schaberg A, Johnson F, Durham T, Ren CL,
Mateos-Corral D, Cutz E, Solomon M, Ratjen F: Plastic bronchitis
Ratjen F, Moss RB, Accurso FJ: Aerosol and pharmacokinetic
as an unusual cause of mucus plugging in cystic fibrosis.
properties of denfusol support its use for early intervention in CF
Pediatric Pulmonology 2009: 44: pp 939-940.
lung disease. Journal of Cystic Fibrosis 2010: 9(Suppl.1): p. S21.
Moraes TJ, Rafii B, Niessen F, Suzuki T, Ruf W, OтАЩBrodovich H,
Nicholas D, Dell SD, Fleming-Carroll B, Selkirk E: An evaluation
Downey GP: Effect of Protease Activated Receptor (PAR) 1 on
of pediatric asthma educational resources. Social Work in Health
distal lung epithelial integrity. Experimental Lung Research
Care 2009: 48: pp 450-461.
2009: 35: pp 136-154.
OтАЩGorman C, Simoneau-Roy J, Pencharz P, MacFarlane J,
Moraes TJ: Arginase and respiratory viral infections. The Open
McLusky I, Narang I, Adeli K, Daneman D, Hamilton J: Sleep
Nitric Oxide Journal 2010: 2: pp 64-68.
disordered breathing is increased in obese adolescents with
Nadeau K, Mandeville I, Xu M, Weiss ST, Sweezey NB, Kaplan F:
of Clinical Endocrinology and Metabolism 2010: 95: pp
Modulation of Lgl1 by steroid, retinoic acid and Vitamin D
2211-2218.
craniopharyngioma compared with obese controls. The Journal
models complex transcriptional regulation during alveolarization.
Pediatric Research 2010: 67: pp 375-381.
Radhakrishnan D, Yau Y, Corey M , Richardson S, MD, Chedore P,
Jamieson F, Dell SD: Non-tuberculous mycobacteria in pediatric
Narang I, Bush A, Rosenthal M: Gas transfer and pulmonary
patients with CF: Prevalence, Clinical predictors and sputum
blood flow at rest and exercise in adults 21 years after preterm
decontamination methods. Pediatric Pulmonology 2009: 44:
birth. American Journal of Respiratory and Critical Care Medicine
pp 1100-1106.
2009: 180: pp 339-345.
Ranganathan K, Worley S, Michaels MG, Arrigan S, Aurora P,
Nash EF, Stephenson A, Ratjen F, Tullis E. Nebulized and oral
Ballmann M, Boyer D, Conrad C, Eichler I, Elidemir O, Glodfarb S,
thiol derivatives for pulmonary disease in cystic fibrosis.
Mallory GB Jr, Mogayzel PJ, Parakininkas D, Solomon M, Visner
Cochrane Database of Systematic Reviews 2009: 21(1):
G, Sweet SC, Faro A, Danziger-Isakov LA: Cytomegalovirus
CD007168.
immunoglobulin decreases the risk of cytomegalovirus infection
but not disease after pediatric lung transplantation. The Journal
of Heart and Lung Transplantation 2009: 28: pp 1050-1056.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 183
Ratjen F, Brockhaus F, Angyalosi G: Aminoglycoside therapy
Subbarao P, Becker A, Brook JR, Daley D, Mandhane PJ,
against pseudomonas aeruginosa in cystic fibrosis: A review.
Miller GE, Turvey SE, Sears MR, the CHILD Study Team, including
Journal of Cystic Fibrosis 2009: 8(6): pp 361-369.
Dell SD: Epidemiology of asthma: Risk factors for development.
Expert Review of Clinical Immunology 2009: 5: pp 77-95.
Ratjen F, Munck A, Kho P, Angyalosi G: Treatment of early
pseudomonas aeruginosa infection in patients with cystic fibrosis:
Subbarao P, Mandhane PJ, Sears MR: Asthma: Epidemiology,
The ELITE trial. Thorax.2009: December 8 [Epub ahead of print].
etiology and risk factors. Canadian Medical Association Journal
2009: 181(9): pp e181-e190.
Ratjen F: Cystic fibrosis: Pathogenesis and future treatment
strategies. Respiratory Care 2009: 54(5): pp 595-605.
To T, Dell SD, Tassoudji M, Wang C: A population-based
Ratjen F: Update in Cystic Fibrosis 2009. American Journal of
on health outcomes in Canadian children. Chronic Diseases
Respiratory and Critical Care Medicine 2009: 179(6): pp 445-448.
in Canada 2009: 29: pp 49-55.
Rose J, Ellis L, John B, Martin S, Gonska T, Solomon M, Tullis E,
To T, Wang C, Dell SD, Fleming-Carroll B, Parkin P, Scolnik D,
Corey M, Adeli K, Durie P: Does the Macroduct┬о collection
Ungar W,The PAMG Team: Can an evidence-based guideline
longitudinal study on the impact of asthma and low-income
system reliably define sweat chloride concentration in subjects
reminder card improve acute asthma management in the
with intermediate results. Journal of Clinical Biochemistry 2009:
emergency department? Respiratory Medicine 2010: 104:
42: pp 1260-1264.
pp 1263-1270.
Saiman L, Anstead M, Mayer-Hamblett N, Lands LC, Kloster M,
Ulrich M, Worlitzsch D, Viglio S, Siegmann N, Iadarola P, Shute JK,
Hocevar-Trnka J, Goss CH, Rose LM, Burns JL, Marshall BC,
Geiser M, Pier GB, Friedel G, Barr ML, Schuster A, Meyer KC,
Ratjen F, AZ0004 Azithromycin Study Group: Effect of
Ratjen F, Bjarnsholt T, Gulbins E, D├╢ring G: Alveolar inflammation
azithromycin on pulmonary function in patients with cystic
in cystic fibrosis. Journal of Cystic Fibrosis 2010: 9(3): pp 217-227.
fibrosis uninfected with Pseudomonas aeruginosa: a randomized
controlled trial. Journal of the American Medical Association
Wilkes DL, Schneiderman JE, Nguyen T, Heale L, Moola F,
2010: 303(17): pp 1707-1715.
Ratjen F, Coates AL, Wells GD: Exercise and physical activity in
children with cystic fibrosis. Paediatric Respiratory Review 2009:
Smyth A, Merkus P, Barbato A, Beydon N, Bisgaard H, de Boeck K,
10(3): pp 105-109.
Brand P, Bush A, Fauroux B, de Jongste J, Pijnenburg M, Korppi M,
OтАЩCallaghan C, Ratjen F,Southern K, Spencer D, Thomson A,
Zhang H, Garber SJ, Cui Z, Foley JP, Mohan GS, obanputra M,
Vyas H, Warris A: Respiratory medicines for children: Current
Kaplan F, Sweezey NB, Gonzales LW, Savani RC: The angiogenic
evidence, unlicensed use and research priorities. European
factor midkine is regulated by dexamethasone and retinoic acid
Respiratory Journal 2010: 35(2): pp 247-265.
during alveolarization and in Type II alveolar epithelial cells.
Respiratory Research 2009: 10: p 77.
184
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Books and Book Chapters
A study to investigate the use of the AeroEclipse* II breath
Amin R, Grasemann H: Pulmonary complications. In: The Hospital
actuated nebulizer for the delivery of methacholine chloride
for Sick Children Handbook of Supportive Care in Pediatric
bronchoprovocation agent. Dell SD. Ontario Ministry of Health
Oncology (Abla O, Breakey VR, Dupuis LL, Naqvi A, Troung TH,
and Long-Term Care Health Technology Assessment and
eds.). Jones and Bartlett Publishers, Sudbury, MA, 2009.
Implementation Program ($174,455 2010-2011)
Solomon M, Grasemann H, Keshavjee S: Pediatric lung
AllerGen-Karolinska Institute International Partnership Initiative
transplantation. In: Optimization of Outcomes for Children after
(IPI). Subbarao PJ. AllerGen NCE Inc. ($20,000 2009-2010)
Solid Organ Transplantation. Pediatric Clinics of North America
(Ng V, Feng S, eds.). Elsevier, Toronto, 2010.
Canadian Birth Cohort: Indoor air and the development of
asthma and allergy. Bleakley C, Kane K, McElhaney J, Watts TH,
Solomon M, Grasemann H: Cystic fibrosis update on diagnosis
Moraes TJ. Canadian Institutes of Health Research
and treatment. In: Cystic fibrosis: Etiology, diagnosis and
($4,201,000 2007-2013)
treatments (Leatte PN, ed.). Nova Science Publishers Inc.,
New York, USA 2009.
Canadian Birth Cohort: Indoor air and the development of
asthma and allergy (CHILD Study). Canadian Institutes of
Suri R, Narang I. Gastro-oesophageal reflux and aspiration. In:
Health Research ($12,000,000 2007-2013)
Colour Atlas of Paediatric Lung Disease (Davies J, Bush A, eds.).
Clinical Publishing, Oxford, 2010.
Canadian Child Health Clinician Scientist Program (CCHCSP):
Strategic training program grant. Rosenblum N, Sweezey N.
Funding
Canadian Institutes of Health Research/SickKids Foundation/
A multi-stage population based study to determine the
BC Women and ChildrenтАЩs Maternal Infant Child & Youth
association between air pollution and asthma. Dell SD.
Research Network ($1,500,000 2002-2015)
Health Canada ($76,442 2009-2011)
Canadian healthy infant longitudinal development study, Toronto
A phase 3, international, multi-centre, randomized, double-blind,
Site. Subbarao PJ. Private donations from Bothwell Accurate
placebo-controlled, parallel group, efficacy and safety study of
and Golden Thread Charitable Foundation for the CHILD Study/
denufosol tetrasodium inhalation solution in patients with cystic
SickKids Foundation ($1,100,000 2008-2013)
fibrosis lung disease and FEV1= 75% predicted. Solomon M,
Ratjen F. Inspire Pharmaceutical Inc. ($42,046 2008-2010)
Childhood Asthma Management Program (CAMP) CAMP-CS III:
The Hospital for Sick Children Clinical Centre for Study of a
A phase 3, randomized, double blind, placebo-controlled, parallel
Childhood Asthma Management Program тАУ Continuation Study.
group study to evaluate the efficacy and safety of VX-770 in
John Hopkins University Centre for Clinical Trials. Grasemann H.
subjects with cystic fibrosis and the G551D mutation protocol
National Institutes of Health, National Heart, Lung and Blood
VX08-770-102 Version 3.0. Ratjen F. (Subject to patient
Institute ($370,633 2008-2011)
enrollment plus $15,431 in any extra costs 2008-2010)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 185
Cystic Fibrosis Foundation Therapeutics Inc. Inhaled Saline
Expanded access program for aztreonam lysine for inhalation
for Infants Study (ISIS-002). National Institutes of Health
in canadian patients with cystic fibrosis and pseudomonas
($1,794,674 US 2008-2012)
aeruginosa airway infection who have limited treatment
options and are at risk for disease progression. Solomon M,
Defining a disease-specific HRQOL tool for primary ciliary
Ratjen F. Gilead Sciences (Funding based on patient enrollment
dyskinesia. Dell SD, Leigh M. NC Tracs Institute Pilot Grant
2009-2010)
Program ($10,000 2009-2010)
Functional analyses of two novel, developmentally-regulated
Defining the role of stenotrophomonas maltophilia in CF patients.
glucocorticoid-responsive genes in fetal lung. Kaplan F,
Waters V, Ratjen F. Canadian Cystic Fibrosis Foundation
Sweezey N. Canadian Institutes of Health Research ($170,000
($240,000 2009-2011)
2009-2011)
Does complicated pneumonia lead to chronic lung disease?
Functional relevance of altered l-arginine metabolism in cystic
Dell SD, Cohen E, Weinstein M. Paediatric Consultants Grant
fibrosis lung disease. Grasemann H, Ratjen F. Canadian Cystic
($9,900 2010-2011)
Fibrosis Foundation ($170,000 2009-2011)
Emerging Team Grant: From genes to proteins, cells, tissues and
Genetic Diseases of Mucociliary Clearance Consortium.
patients. Ratjen F. Canadian Institutes of Health Research
Dell SD, Knowles M. National Institutes of Health ($6,709,385
($2,401,449 2009-2014)
2009-2014)
Enhancing CD8 T cell immune responses to RSV. Moraes TJ.
High Impact Strategies Towards Overweight Reduction in Youth
DeanтАЩs Fund New Staff Competition, University of Toronto
(HISTORY) Team Grant. Narang I. Canadian Institutes of Health
($10,000 2009-2014)
Research ($2,322,370 2008-2013)
Enhancing CD8 T cell immune responses to RSV. Moraes TJ. The
Influenza infection of human endothelium leads to microvascular
Hospital for Sick Children, Start-up Operating/Equipment Fund
leak: Cellular and molecular mechanisms. Lee W, Moraes TJ.
($456,000 2008-2012)
Ontario Thoracic Society ($49,945 2010-2011)
Estimating environmental population attributable risk for asthma
Lab technician, salary support. Grasemann H. The Lynne and
in Canadian children. Dell SD. Health Canada (Vulnerable
Arnold Irwin Foundation ($44,171 2009-2010)
Populations Office) ($24,698 2009-2010)
Making the link between objective measures of airway disease
and epidemiological survey data. Dell SD. Ontario Lung
Association ($50,000 2009-2010)
186
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Masters project funding to Wallace Wee: The accurate prediction
Respiratory syncytial virus in the development of infant wheezing
of drug lung deposition based on the combination of nebulizer
disorders: a bench to bedside approach to gene-virus
performance and the patientтАЩs age and pattern of breathing.
interactions. Subbarao P. AllerGen NCE Inc. ($176,800
Natural Sciences and Engineering Research Council of Canada
2009-2012)
($17,500 2009-2010)
Serum biomarkers as predictors of bronchiolitis obliterans in
Modulation by sex hormones of inflammation and susceptibility
children receiving allogeneic hematopoietic stem cell
to Pseudomonas aeruginosa in cystic fibrosis airways. Sweezey N.
transplantation: a pilot study. Dell SD, Gassas A.
Canadian Cystic Fibrosis Foundation ($170,000 2009-2011)
Comprehensive Cancer Centre ($50,121 2009-2010)
Non-Adherence in Paediatric Multi-Organ Transplant Recipients.
Start Up Operating Fund. Narang I. SickKids Research Institute
Solomon M, Pollock-BarZiv S. Astellas Pharma Research Grant
($110,000 2008-2010)
($25,500 2008-2009)
Surfactant protein D controls inflammatory response and
Open-label extension of study 08-110 тАУ A multi-center study of
modulates NO synthesis in the cystic fibrosis lung. Grasemann
denufosol tetrasodium inhalation solution in patients with cystic
H. Ontario Student Opportunity Trust Fund/Restracomp
fibrosis lung disease. Solomon M, Ratjen F. Inspire Pharmaceutical
($60,000 2008-2011)
Inc. (Funding based on patient enrollment 2009-2010)
Team grant: Pandemic preparedness - Influenza biology Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in
Correlates to protection against influenza illness: From mouse to
Cystic Fibrosis (PUSH): Summary for CF care providers. Solomon
older adultsтАЩ. Becker A, Mandhane PJ, Sears MR, Subbarao P,
M, Ratjen F. Cystic Fibrosis Foundation/National Institutes of
Turvey S, Moraes TJ. Canadian Institutes of Health Research
Health (Funding based on patient enrollment 2008-2013)
($1,471,350 2008-2011)
Platform for Outcomes Research and Translation in Asthma and
The Canadian Health Infant Longitudinal Development (CHILD)
aLlergy (PORTAL). Dell SD, Lynds L. AllerGen NCE Inc.
Study. Grasemann H. Canadian Institutes of Health Research
($300,000 2009-2014)
($12,000,000 2007-2013)
Pilot Study to validate a system for measuring the lung clearance
The Canadian Infant Longitudinal Development (CHILD) Study.
index in children. Ratjen, F. Cystic Fibrosis Foundation
Dell SD, Sears M. Canadian Institutes of Health Research
Therapeutics ($50,000 2010-2014)
($12,000,000 2008-2013)
Respiratory population-based Outcomes Network: Studies and
Young infants with acute recurrent wheezing тАУ To puff or not to
Evaluations (RESPONSE). Dell SD, To T. Canadian Institutes of
puff? Grasemann H. SickKids Foundation/Canadian Institutes
Health Research ($445,780 2007-2009)
of Health - Institute of Human Development, Child and Youth
Health ($130,000 2008-2010)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 187
Division Head
Dr. Brian Feldman
Full-Time
Dr. Susanne Benseler
Dr. Ronald Laxer
Dr.
Dr.
Dr.
Dr.
Deborah Levy
Rayfel Schneider
Shirley Tse
Rae Yeung
Major Part-Time
Dr. Earl Silverman
Dr. Lynn Spiegel
Part-Time
Dr. Bonnie Cameron
Fellows
Dr. Daniela Ardelean
Dr. Michelle Batthish
Dr. Roberta Berard
Dr. Nicholas Blanchette
Dr. Tania Cellucci
Dr. Tassalapa Daengsuwan
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Karoon Danayan
Boris Hugle
Clare Hutchinson
Sylvia Kamphuis
Lily Lim
Nadia Luca
Heinrike Schmeling
Division of Rheumatology
Divisional Overview
Honours and Awards
The Division of Rheumatology provides comprehensive care for
Benseler S: James C. Fallis Teaching Award, Division of
children with rheumatic diseases. The ambulatory clinics have
Paediatric Emergency Medicine, The Hospital for Sick Children,
approximately 5,000 patient visits a year at The Hospital for
2009-2010.
Sick. In addition to the general rheumatology clinics, there are
unique multidisciplinary subspecialty clinics for children with
Benseler S: Clinical Recognition Award тАУ Staff Physician
dermatomyositis, morphea, systemic JIA, systematic and
Part-time, Division of Paediatric Emergency Medicine,
neonatal lupus erythematosus, spondylitis and inflammatory
The Hospital for Sick Children, 2009-2010.
brain disease. A new clinic has been started for children with
fever syndromes. Many children have benefited from treatments
Laxer R: The Distinguished Clinician Scholar Award from the
in the medical day care unit, where children receive joint
American College of Rheumatology, Philadelphia, 2009
injections, therapeutic infusions or undergo investigations
that would normally require in-patient admission.
Levy D: Future Leaders in Rheumatology (FLIRT).
Our program offers a comprehensive range of services for the
Schneider R: Ontario Ministry of Health, Celebrating
evaluation and treatment of children with the vast range of
Innovations in Health Care Expo: Innovations in Health
paediatric rheumatic and inflammatory diseases. Rheumatology
Human Resources Award of Excellence, 2009.
provides clinical care and undertakes research studies in
systemic inflammatory disorders and inflammatory diseases
Silverman ED: The Inaugural Chair Holder, the Ho Family Chair
of the bones and joints.
in Autoimmune Diseases, 2009.
The Division of Rheumatology has the largest paediatric
Silverman ED: Distinguished Investigator Award, the Canadian
rheumatology fellowship training program in North America
Rheumatology Association, 2010.
and is fully accredited by the Royal College of Physicians and
Surgeons of Canada. This academic year, our fellows originated
Tse SML: Department of Paediatrics Award for Teaching
from Netherlands, Thailand, Germany and Singapore. Our
Excellence for the Paediatric Resident Lecture Series, 2010.
graduates have been successful in obtaining academic
placements around the world and trainees have been productive
in the research arena.
Tse SML: Department of Paediatrics Scholarship for Education
Scholar Program, Centre for Faculty Development, University of
Toronto, 2010.
Research foci include the development of a trial design for the
study of rare diseases, outcome, prognosis and treatment
Yeung RSM: Henry Kunkel Young Investigator Award, American
studies in juvenile idiopathic arthritis, systemic lupus
College of Rheumatology, September 2009.
erythematosus, neonatal lupus, scleroderma, dermatomyositis,
vasculitis and CNS vasculitis.
Yeung RSM: Royal College Professional Development Grant,
Royal College of Physicians and Surgeons, September 2009.
Basic research focuses on the immunopathogenesis of
Kawasaki disease using an animal model.
Yeung RSM: Dafna Gladman Award, Rheumatic Diseases Unit,
University of Toronto, Toronto, Ontario, June 2009.
research associates
Matthew Gronski
Marjorie McLimont
Lawrence Ng
Reena Riarh
Shehla Sheikh
Aram Zakerzaeh
Administrative Staff
Sandra Bergeron
Lynn Brown
Jack├иe Colquhoun
Shona Magee
Roseanne Richard
Tania Viseu
Publications
Brunner HI, Klein-Gitelman MS, Ying J, Tucker LB, Silverman ED:
Al M, Ng L, Tyrrell P, Bargman J, Bradley T, Silverman E:
Corticosteroid use in childhood-onset systemic lupus
Adipokines as novel biomarkers in paediatric Systemic Lupus
erythematosus - practice patterns at four pediatric
Erythematosus. Rheumatology 2009: 48(5): pp 497-501.
rheumatology centers. Clinical and Experimental
Rheumatology 2009: 27(1): pp 155-162.
Armstrong DL, Reiff A, Myones BL, Quismorio Jr. FP, KleinGitelman M, McCurdy D, Wagner-Weiner L, Silverman E, Ojwang
Brunner J, Kuemmerle-Deschner JB, Tyrrell P, Feldman B,
JO, Kaufman KM, Kelly JA, Merrill JT, Harley JB, Bae SC, Vyse TJ,
Benseler SM. Takayasu arteritis in children and adolescents.
Gilkeson GS, Gaffney PM, Moser KL, Putterman C, Edberg JC,
Rheumatology (Oxford) 2010: June 18 [Epub ahead of print].
Brown EE, Ziegler J, Langefeld CD, Zidovetzki R, Jacob CO:
Identification of new SLE-associated genes with a two-step
Butbul AY, Tyrrell PN, Schneider R, Dhillon S, Feldman BM,
bayesian study design. Genes & Immunology 2009: 10(5):
Laxer RM, Saurenmann RK, Spiegel L, Cameron B, Tse SM,
pp 446-456.
Silverman ED: Comparison of patients with juvenile psoriatic
arthritis and nonpsoriatic juvenile idiopathic arthritis: how
Baker AL, Lu M, Minich LL, Atz AM, Klein GL, Korsin R, Lambert L,
different are they? Journal of Rheumatology 2009: 36(9):
Li JS, Mason W, Radojewski E, Vetter VL, Newburger JW,
pp 2033-2041.
Yeung RSM, Pediatric Heart Network Investigators. Associated
symptoms in the ten days before diagnosis of Kawasaki
Cabral DA, Uribe AG, Benseler S, OтАЩNeil KM, Hashkes PJ,
disease. Journal of Pediatrics 2009: 154(4): pp 592-595.
Higgins G, Zeft A, Zeft AS, Lovell DJ, Kingsbury DJ, Stevens A,
Baker K, Pope J, Fortin P, Silverman E, Peschken C. Work
Eberhard A, Hersh AO, Huber AM, Kim S, Klein-Gitelman M,
disability in systemic lupus erythematosus is prevalent and
Levy D, Li SC, Mason T, Dewitt EM, Muscal E, Nassi L, Reiff A,
associated with socio-demographic and disease related factors.
Schikler KN, Singer NG, Wahezi D, Woodward A: ARChiVE
Lupus 2009: 18(14): pp 1281-1288.
(A Registry for Childhood Vasculitis: e-entry) Investigators
McCurdy D, Chira P, Abramson L, Arkachaisri T, Campillo S,
Network. Classification, presentation and initial treatment of
Batthish M, Bassilious E, Blanchette N, Soon G, Luca N,
WegenerтАЩs Granulomatosis in childhood: Arthritis &
St Bernard R, Cameron T, Bahr T, Hyman A, Tait G, Feldman B,
Rheumatism 2009: 60(11): pp 3413-3424.
Schneider R, Tse SML: The development of an interactive
web-based rheumatology teaching module. Arthritis &
Rheumatism 2009: 60(10): pp 508.
Chahal N, Clarizia NA, McCrindle BW, Boydell KM, Obadia M,
Manlhiot C, Dillenburg R, Yeung RSM: Parental anxiety
associated with Kawasaki disease in previously healthy
Brunner HI, Klein-Gitelman MS, Higgins GC, Lapidus SK,
children. Journal of Pediatric Health Care 2009: 23(6):
Levy DM, Eberhard A, Singer N, Olson JC, Onel K, Punaro M,
pp 372-377.
Schanberg L, von Scheven E, Ying J, Giannini EH: Toward the
development of criteria for global flares in juvenile systemic
Dugan EM, Huber AM, Miller FW, Rider LG, Feldmand BM:
lupus erythematosus. Arthritis Care Research 2010: 62(6):
Photoessay of the cutaneous manifestations of the idiopathic
pp 811-820.
inflammatory myopathies. Dermatology Online Journal 2009:
15(2): p 1.
190
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Dugan EM, Huber AM, Miller FW, Rider LG, Feldman BM:
Hutchinson C, Tse SM: Biologic therapies in children with Juvenile
Review of the classification and assessment of the cutaneous
Idiopathic Arthritis. Joint Perspectives 2009: 1(4): pp 2-3.
manifestations of the idiopathic inflammatory Myopathies.
Dermatology Online Journal 2009: 15(2): p 2.
Hutzal CE, Wright FV, Stephens S, Schneiderman-Walker J,
Filler G, Sharma AP, Levy DM, Yasin A. Random
experiences leading an exercise program for children with
pharmacokinetic profiles of EC-MPS in children with
juvenile idiopathic arthritis. Physical & Occupational Therapy
autoimmune disease. Pediatric Rheumatology Online
in Pediatrics 2009: 29(4): pp 409-425.
Feldman BM: A qualitative study of fitness instructorsтАЩ
Journal 2010: 8(1): p 1
Jackson C, MacDonald M, Anderson M, Stevens P, Gondon P,
Globe D, Young NL, Von Mackensen S, Bullinger M, Wasserman
Laxer R: Improving communication of critical test results in a
J, Feldman BM, Healthrelated Quality of Life Expert Working
paediatrics academic setting - Key lessons in achieving and
Group of The International Prophylaxis Study Group: Measuring
sustaining positive outcomes. Healthcare Quarterly - Patient
patient-reported outcomes in haemophilia clinical research.
Safety Papers 2009: 12: pp 116-122.
Haemophilia 2009: 15(4): pp 843-852
Jaeggi ET, Golding F, Silverman ED: Perinatal outcome of fetal
Hiraki LT, Benseler SM, Tyrrell PN, Harvey E, Hebert D,
atroventricular block: One-hundred sixteen cases from a single
Silverman ED: Ethnic Differences in pediatric systemic lupus
institution. Circulation 2009: 119(20): p 539.
erythematosus (pSLE). Journal of Rheumatology 2009: 36(11):
pp 2539-2546.
Johnson SR, Tomlinson GA, Hawker GA, Granton JT, Grosbein
Hugle B, Laxer RM: Lipoatrophy resulting from steroid injection
for bayesian priors. Journal of Clinical Epidemiology 2010:
into the temporomandibular joint. Arthritis & Rheumatism
63(4): pp 370-383.
HA, Feldman BM: A valid and reliable belief elicitation method
2009: 60(11): p 3512.
Johnson SR, Feldman BM, Pope J, Tomlinson G: Shifting our
Hugle B, Solomon M, Harvey E, James A, Wadhwa A, Amin R,
thinking of uncommon disease trials: The case of
Bell-Peter A, Benseler SM: Pneumocystis jirovecii pneumonia
methotrexate in scleroderma. Journal of Rheumatology 2009:
following Rituximab treatment in WegenerтАЩs Granulomatosis.
36(2): pp 323-329.
Arthritis Care & Research (Hoboken) 2010: June 25 [Epub
ahead of print].
Kashiwada M, Levy DM, McKeag L, Murray K, Schr├╢der A,
Canfield SM, Traver G, Rothman PB: Interleukin-4-induced
Hurdowar A, Urmson L, Bohn D, Geary D, Laxer R, Stevens P:
transcription factor NFIL3/E4BP4 controls IgE class switching.
Compliance with a pediatric clinical practice guideline for
Proceedings of the National Academy of Sciences USA 2010:
intravenous fluid and electrolyte administration. Healthcare
107(2): pp 821-826
Quarterly - Patient Safety Papers 2009: 12: pp 129-134.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 191
Kumar S, Kirby-Allen M, Benseler S, Silverman E: B Cell
Manlhiot C, Yeung RSM, Chahal C, McCrindle BW: Intravenous
depletion for autoimmune thrombocytopenia and autoimmune
immunoglobulin preparations influence outcomes in patients
hemolytic anemia in pediatric Systemic Lupus Erythematosus:
with acute Kawasaki disease. Pediatric Allergy and Immunology
A single center experience Pediatrics 2009: 123(1): pp 159-163.
2010: 21(3): pp 515-521.
Lau AC, Duong TT, Ito S, Wilson GJ, Yeung RSM: Inhibition of
Manlhiot C, Yeung RSM, Clarizia NA, Chahal N, McCrindle BW:
MMP-9 activity improves coronary outcome in an animal model
Kawasaki disease at the extremes of the age spectrum: Similar
of Kawasaki disease. Clinical and Experimental Immunology
outcomes, different associated factors. Pediatrics 2009:
2009: 157(2): pp 300-309.
124(3): pp 409-415.
Lau AC, Duong TT, Ito S, Yeung RSM: IVIG and salicylate
Matlow AG, Moody L, Laxer R, Stevens P, Goia C, Friedman JN:
differentially modulate pathogenic processes leading to
Disclosure of medical error to parents and paediatric patients:
vascular damage in Kawasaki disease. Arthritis and
Assessment of parentsтАЩ attitudes and influencing factors.
Rheumatism 2009: 60(7): pp 2131-2141.
Archives of Disease in Childhood 2010: 95(4): pp 286-290.
Levy DM, Bingham CA, Kahn PJ, Eichenfield AH, Imundo LF:
McDonnell C, Laxer R, Roy L: Redesigning a Morbidity and
Favorable Outcome of Juvenile Dermatomyositis treated
Mortality Program in a University-Affiliated Pediatric Anesthesia
without systemic corticosteroids. Journal of Pediatrics 2010:
Department. Journal on Quality and Patient Safety 2010:
156(2): pp 302-307.
36(3): pp 117-125.
Levy DM, Imundo LF. Nonsteroidal Anti-inflammatory Drugs
Mittoo S, Gelber AC, Hitchon CA, Silverman ED, Pope JE,
(NSAIDs): Practices and concerns of pediatricians and
Fortin PR, Pineau C, Smith CD, Arbillaga H, Gladman DD,
pediatric subspecialists. Pediatric Rheumatology Online
Urowitz MB, Zummer M, Clarke AE, Bernatsky S, Hudson M,
Journal 2010: 8: p 7.
Tucker LB, Petty RE, Peschken CA. Clinical and serologic
factors associated with lupus pleuritis. Journal of
Li SC, Feldman BM, Higgins GC, Haines KA, Punaro MG,
Rheumatology 2010: 37(4): pp 747-753.
OтАЩNeil KM: Treatment of pediatric localized scleroderma:
Results of a survey of North American pediatric rheumatologists.
Namjou B, Sestak AL, Armstrong DL, Zidovetzki R, Kelly JA,
Journal of Rheumatology 2009: 37(1): pp 175-181.
Ciobanu V, Kaufman KM, Ojwang JO, Ziegler J, Quismorio FP,
Reiff A, Myones BL, Guthridge JM, Nath SK, Bruner GR,
Mahler M, Silverman ED, Schulte-Pelkum J, Fritzler MJ:
Mehrian-Shai R, Silverman E, Klein-Gitelman M, McCurdy D,
Anti-Scl-70 (topo-I) antibodies in SLE: Myth or reality?
Wagner-Weiner L, Nocton JJ, Putterman C, Bae S-C, Kim YJ,
Autoimmunity Reviews 2010: June 22 [Epub ahead of print].
Petri M, Reveille JD, Vyse TJ, Gilkeson GS, Kamen DL,
Alarcon-Riquelme ME, Gaffney PM, Moser KL, Merril JT,
Scofield RH, James JA, Langefeld CD, Harley JB, Jacob CO:
High-density genotyping of STAT4 reveals multiple haplotypic
associations with systemic lupus erythematosus in different
racial groups. Arthritis & Rheumatism 2009: 60(4):
pp 1085-1095.
192
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Nulman I, Rovet J, Barrera M, Knittel-Keren D, Feldman BM,
Peschken C, Katz S, Silverman E, Pope J, Fortin P, Pineau C,
Koren G: Long-term neurodevelopment of children exposed
Smith C, Arbillaga H, Gladman D, Urowitz M, Zummer M,
to maternal nausea and vomiting of pregnancy and diclectin.
Clarke AE, Bernatsky S, Hudson M, Canadian Network for
Journal of Pediatrics 2009: 155(1): pp 45-50
Improved Outcomes in Systemic Lupus Erythematosus
Oen K, Duffy C, Tse S, Ramsey S, Ellsworth J, Chedeville G,
of Disease outcome in a large multi-ethnic cohort. Journal of
Chetaille AL, St. Cyr C, Cabral D, Spiegel L, Schneider R,
Rheumatology 2009: 36(6): pp 1200-1208.
(CaNIOS): The 1000 Canadian faces of Lupus: Determinants
Lang B, Huber A, Dancey P, Silverman E, Rosenberg AM,
Cameron B, Johnson N, Dorval J, Scuccimarri R, Campillo S,
Rider LG, Lachenbruch PA, Monroe JB, Ravelli A, Cabalar I,
Petty RE, Duffy K, Boire G, Haddad E, Houghton K, Laxer RM,
Feldman BM, Villalba ML, Myones BL, Pachman LM,
Turvey S, Miettunen P, Gross K, Guzman J, Benseler S,
Rennebohm RM, Reed AM, Miller F (IMACS Group): Damage
Feldman B, Cheang M, Espinosa V, Yeung R, Tucker L: Early
Extent and predictors in adult and juvenile dermatomyositis
outcomes and improvement of patients with Juvenile Idiopathic
and polymyositis as determined with the myositis damage
Arthritis enrolled in a Canadian multicentre inception cohort.
index. Arthritis & Rheumatism 2009: 60(11): pp 3425-3435
Arthritis Care & Research (Hoboken) 2010: 62(4): pp 527-536.
Ross GS, Zelko F, Klein-Gitelman M, Levy DM, Muscal E,
Oen K, Tucker L, Huber AM, Miettunen P, Scuccimarri R,
Schanberg L, Anthony K, Brunner HI: A proposed framework to
Campillo S, Cabral DA, Feldman BM, Tse S, Chedeville G,
standardize the neurocognitive assessment of patients with
Spiegel L, Schneider R, Lang B, Ellsworth J, Ramsey S,
pediatric Systemic Lupus Erythematosus. Arthritis Care
Dancey P, Silverman E, Chetaille AL, Cameron B, Johnson N,
Research 2010: 62(7): pp 1029-1030.
Dorval J, Petty RE, Duffy KW, Boire G, Haddad E, Houghton K,
Saint-Cyr C, Turvey SE, Benseler S, Cheang M, Yeung RSM,
Ruperto N, Lovell DJ, Cuttica R, Woo P, Meiorin S, Wouters C,
Duffy CM: Predictors of Early Inactive Disease in a Juvenile
Silverman ED, Balogh Z, Henrickson M, Davidson J, Foeldvari I,
Idiopathic Arthritis Cohort: Results of a Canadian Multicenter,
Imundo L, Simonini G, Oppermann J, Xu S, Shen Y-K,
Prospective Inception Cohort Study. Arthritis & Rheumatism
Visvanathan S, Fasanmade A, Mendelsohn A, Martini A,
2009: 61:8: pp 1077-1086.
Giannini EH, Paediatric Rheumatology International Trials
Organization (PRINTO) and the Pediatric Rheumatology
OтАЩShea F, Boyle E, Riarh R, Tse SM, Laxer RM, Inman R:
Collaborative Study Group (PRCSG): Long-term efficacy and
Comparison of clinical and radiographic severity of juvenile-
safety of infliximab plus methotrexate for the treatment of
onset versus adult-onset ankylosing spondylitis. Annals of
polyarticular course juvenile rheumatoid arthritis: Findings
Rheumatic Diseases 2009: 68(9): pp 1407-1412.
from an open-label treatment extension. Annals of Rheumatic
Diseases 2010: 69(4): pp 718-722.
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 193
Schanberg LE, Sandborg C, Barnhart HX, Ardoin SP, Yow E,
Stinson J, McGrath PJ, Hodnett EE, Feldman B, Duffy CM,
Evans GW, Mieszkalski KL, Ilowite NT, Eberhard A, Levy DM,
Huber A, Tucker LB, Hetherington R, Tse SML, Spiegel LR,
Kimura Y, von Scheven E, Silverman E, Bowyer SL, Punaro L,
Campillo SSC, Gill NK, White M: Feasibility testing of an online
Singer NG, Sherry D, McCurdy D, Klein-Gitelman M, Wallace C,
self-management program for adolescents with juvenile
Silver R, Wagner-Weiner L, Higgins G, Brunner HI, Jung L,
idiopathic arthritis (JIA): A pilot randomized controlled trial.
Soep JB, Reed A, for the Atherosclerosis Prevention in Pediatric
Arthritis and Rheumatism 2009: 60(10): p 87.
Lupus Erythematosus Investigators: Premature atherosclerosis
in pediatric systemic lupus erythematosus: Risk factors of
Tomlinson D, Gibson F, Treister N, Baggott C, Judd P,
increased Carotid Intima Medial Thickness (CIMT) in the
Hendershot E, Maloney A-M, Doyle J, Feldman BM, Sung L:
Atherosclerosis Prevention in Pediatric Lupus Erythematosus
Designing An oral mucositis assessment instrument for use
(APPLE) Cohort. Arthritis and Rheumatism 2009: 60(5):
in children: Generating items using a nominal group technique.
pp 1496-1507.
Supportive Care in Cancer 2009: 17(5): p 555.
Sabharwal T, Manlhiot C, Benseler SM, Tyrrell P, Chahal N,
Tyrrell PN, Beyene J, Feldman BM, McCrindle BW, Silverman ED,
Yeung RSM, McCrindle BW: Comparison of factors associated
Bradley TJ. Rheumatic disease and carotid intima-media
with coronary artery dilation only versus coronary artery
thickness: A systematic review and meta-analysis.
aneurysms in patients with Kawasaki disease. American
Arteriosclerosis, Thrombosis, and Vascular Biology 2010:
Journal of Cardiology 2009: 104(12): pp 1743-1747.
30(5): pp 1014-1026.
Saurenmann RK, Levin AV, Feldman BM, Laxer RM, Schneider
Tzaribachev N, Benseler SM, Tyrrell PN, Mayer A,
R, Silverman ED: Risk factors for development of uveitis
Kuemmerle-Deschner JB: Predictors of Delayed Referrals
differ between girls and boys with juvenile idiopathic arthritis.
to a Pediatric Rheumatology Center. Arthritis & Rheumatism
Arthritis & Rheumatism 2010: 62(6): pp 1824-1828.
2009: 61(10): pp 1367-1372.
Stinson JN, Connelly M, Chalom EJ, Chira P, Schanberg LE,
Werner KG, Morel CF, Kirton A, Benseler SM, Shoffner JM,
Rapoff MA., Walco G, Tse SML, Spiegel LR: Ask me where it
Addis JB, Robinson BH, Burrowes DM, Blaser SI, Epstein LG,
hurts? Developing a standardized approach to the assessment
Feigenbaum AS: Rolandic mitochondrial encephalomyelopathy
of pain in children and youth presenting to pediatric rheumatology
and MT-ND3 mutations. Pediatric Neurology 2009: 41(1):
providers. Arthritis & Rheumatism 2009: 60(10): p 577.
pp 27-33.
Yeung RSM: Kawasaki disease: Update on pathogenesis.
Current Opinion in Rheumatology 2010: 22: pp 551-560.
194
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Books and Book Chapters
Application of quantitative gait and spine analysis towards
Cabral D, Tse SM: Pediatric spondyloarthropathy. Pearls and
improving the outcomes of patients with juvenile
Myths in Rheumatology (Stone JH, ed.). Springer Science,
spondyloarthropathy. Tse SM, Zabjek K, Laxer R, Feldman B,
Willowick, OH, 2009.
Whitney-Mahoney K, Anderson M, Heung E. Spondyloarthritis
Research Consortium of Canada ($9,784 2009-2010)
Elbers J, Benseler SM: Central nervous system vasculitis in
inflammatory and autoimmune disorders of the nervous system
Biologically-based outcome predictors in juvenile idiopathic
in children. In: Journal of Neuroimmunology (Raine CS,
arthritis. Rosenberg A, Baxter-Jones AD, Gordon J, Muhajarine,
Brosnan CI, eds.). Elsevier, Bronx, New York, 2009.
N, Oen K, Pahwa P, Scherer S, Turvey S, Von Baever C, Whiting
SJ, Yeung RSM, Bernatsky S, Diffy C, Silverman ED, Cameron B,
Levy DM, Ross G. Cognitive and psychiatric complications of
Laxer R, Spiegel L, Schneider R, Tse S. Canadian Institutes of
childhood-onset SLE (cSLE). In Cognitive And Behavioral
Health Research ($1,500,000 2006-2011)
Manifestations of Pediatric Diseases (Nass R, Frank Y, eds.),
Oxford University Press, 2010.
Canadian arthritis network international partnership initiative.
Silverman ED: Systemic lupus erythematosus, mixed
2007-2009)
Benseler SM. Networks of Centres of Excellence ($590,000
connective tissue disease and overlap connective tissue
diseases. In: RudolphтАЩs Textbook of Pediatrics, 22nd Edition
Cancer risk in pediatric-onset rheumatic disease. Bernatsky S,
(Rudolph C, Rudolph AM, Kamei RK, Overby KJ, eds.).
Silverman E, Clarke A, Duffy C, Rosenberg A: Canadian
McGraw-Hill Medical Publishing Division, New York, 2009.
Institutes of Health Research ($77,745 2009-2011)
Funding
Cerebral venous hemodynamics in pediatric multiple sclerosis.
2000 Faces of lupus. Peschken C, Beyene J, Pope JE,
Banwell B, Macgowan C, Laughlin S, Shroff M, Sled J, Yeung
Scherer S, Silverman ED. Canadian Institutes of Health
RSM, Benseler S, Traubici J, Moharir M, Arnold D, Narayanan S,
Research ($1,500,000 2009-2014)
Bar-Or A, Marrie RA. Multiple Sclerosis Society of Canada
($196,579 2010-2012)
A 12-week randomized, double blind placebo-controlled,
parallel group, 2-arm study to evaluate the efficacy and safety
CIHR team grant in exercise in chronically ill children. Feldman
of Tocilizumab in patients with sJIA тАУ With a 92-weekтАжuse of
BM, Noseworthy MD, Tein I, Wells GD, Biggar WD, Coates AL,
Tocilizumab. Schneider R, Benseler SM. Hoffmann-La Roche
Faulkner G, Hamilton RM, McCrindle BW, Nathan PC, Ratjen F,
Inc., USA ($553,000 2008-2012)
Schneiderman JE, Stephens S, Tarnopolsky MA, Timmons BW,
Tse S, Vajsar J. Canadian Institutes of Health Research
($10,000 2009)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 195
CIHR team in linking exercise, physical activity and
Inflammation and atherosclerosis in pediatric rheumatic
pathophysiology in childhood arthritis: A Canadian collaborative
diseases. Bradley T, Silverman ED, Feldman B, Schneider R,
team (LEAP). Duffy C, Tucker L, Yeung RSM, Mackay H,
Beyene J. Heart and Stroke Foundation of Ontario ($125,488
Baxter-Jones A. Canadian Institutes of Health Research
2007-2009)
($2,500,000 2010-2015)
Inflammation and atherosclerosis in pediatric rheumatic
Determinants of risks and outcomes in inflammatory arthritis.
disease. Bradley T, Silverman ED, Schneider R, Feldman B,
Siminovitch K, Yeung RSM, Bernatsky S, Bombardier C, Boillais
Beyene J. The Heart and Stroke Foundation of Canada
L, MacPherson A, Oen K. Canadian Institutes of Health
($191,533 2008-2011)
Research ($2,000,000 2007-2012)
International juvenile idiopathic arthritis initiative. Yeung RSM,
Development and usability and feasibility testing of a web-
Feldman B, Wedderburn L, Prakken B. Canadian Arthritis
based self-management program for adolescents with arthritis.
Network ($70,000 2009-2010)
McGrath PJ and Stinson J, Hodnett E, Feldman BJ, Duffy C,
Malleson P, Tucker L, Huber A, Hetherington R, Yeung R, Tse S.
Kawasaki disease: On our way to unraveling the pathogenesis.
Canadian Arthritis Network/The Arthritis Society SRID Grant
Yeung RSM. Canadian Institutes of Health Research
($300,000 20072009)
($425,214 2008-2011)
Development of an internet-based psychoeducational program
Molecular expression & physiology in developing atroventricular
for parents and children newly diagnosed with arthritis: Phase I.
nodal cells. Hamilton R, Silverman ED: Canadian Institutes of
Benseler SM. Networks of Centres of Excellence ($162,000
Health Research ($123,500 2006-2009)
2009-2011)
Neurocognitive function in childhood-onset SLE. Levy D,
Development of an internet-based psycho-educational program
Silverman ED, Diamond B, Williams T. National Institutes of
for school-age children with arthritis and their parents: Phase 1.
Health/National Institute of Arthritis and Musculoskeletal
Feldman B, Stinson J, Duffy C, Huber A, Tucker L, McGrath P,
and Skin Diseases K23 Mentored Career Development Award
Tse S, Hetherington R, Spiegel L, Campillo S, Benseler S.
($648,540 US 2007-2012)
Canadian Arthritis Network SRP Grant ($240,000 2009-2010)
New onset juvenile idiopathic arthritis. A Canadian multi-centre
Feasibility of an interactive web-based rheumatology teaching
collaborative outcome study. Duffy C, Oen K, Tucker L, Yeung
module for pediatric residents. Tse SM, Feldman BM,
RSM, Feldman BM, Benseler SM, Schneider R: Canadian
Schneider R, Hyman A, Stringer E, Bassilious E, Batthish M,
Institutes of Health Research ($998,000 2004-2009)
Bendiak G, Gupta S, Bradley N, Cameron T, Tait G, Shouldice M.
Educational Deans Funds Matched with Department of
Open-label extension treatment with TNFR:Fc for participating
Paediatrics Fund ($18,300 2007-2009)
patients in TNFR:Fc clinical trials. Schneider R, Silverman E,
Feldman B, Laxer R, Spiegel L. Amgen ($134,270 1998-2009)
196
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Pharmacogenetics of juvenile idiopathic arthritis and juvenile
The role of chronic inflammation and systemic lupus
dermatomyositis-the influence of polymorphisms in genes of
erythematosus-related factors in the development of premature
enzymes involved in metabolism on the efficacy and toxicity of
atherosclerosis in pediatric SLE. Silverman ED, Bargman J,
methotrexate. Schmeling H, Yeung RSM, Feldman B,
Bradley T, Beyene J. The Heart and Stroke Foundation of
Siminovitch K. The Alberta ChildrenтАЩs Hospital Foundation
Canada ($275,000 2006-2009)
($45,217 2009-2010)
Towards a better understanding of Kawasaki disease.
Physician-researchers in pediatrics: A study on dual
Yeung RSM. Heart and Stroke Foundation of Canada
accountability. Zlotnik RS, Boydell K, dтАЩAjincourt-Canning L,
($239,158 2008-2011)
Simpson C, Levin A, McDonald N, McFadden J, Sampson H,
Schneider R, Strahlendorf C. Canadian Institutes of Health
Towards a harmonized approach to the conduct of research in
Research ($78,398 2008-2010)
childhood arthritis worldwide. Yeung RSM, Feldman B,
Wedderburn L, Prakken B. Ministry of Research and Innovation
Research in Childhood Arthritis and Rheumatic Disease
of Ontario, International Opportunities Program ($450,000
(CARD): A collaborative cross Canada research training
2010-2013)
program to enhance quality of life. Yeung R, Schneider R,
Cameron B, Laxer R, Spiegel L, Tse S. Canadian Institutes
of Health Research ($1,800,000 2005-2011)
Towards understanding the mechanism of congenital heart
block. Hamilton RH, Gross G, Silverman ED. Canadian
Institutes of Health Research ($197,000 2006-2009)
Research to improve outcomes for inflammatory arthritis.
Inman R, Gladman D, Maksymowych W, Rahman P, Boonen A,
Validation of BASDAI and BASFI in children with
Choquette D, Colbert R, Frank J, Ghahary A, Gignac M, Husted
spondyloarthropathy. Tse SM, Feldman B, Laxer R, Anderson M,
J, Keen K, Lambert R, Laxer R, Marra C, Mosher D, Mulholland
Whitney K, Marcuz J. Spondyloarthritis Research Consortium
K, Nair B, Poole R, Richards C, Salonen D, Shojania K,
of Canada ($9,842 2009-2010)
Thomson G, Tse S. The Spondyloarthritis Research
Consortium of Canada/The Arthritis Society/National
Research Initiative ($2,500,000 2006-2010)
Widening the therapeutic window in acute ischemic stroke with
blood-brain-barrier permeability and its relationship with
corresponding blood markers: Implications for short and
Superantigens in autoimmunity. Yeung RSM. Canadian
long-term outcomes. Kassner A, Yeung RSM. Heart and Stroke
Institutes of Health Research ($461,325 2009-2012).
Foundation of Canada ($136,490 2010-2012)
System level evaluation of the ACPAC program graduates:
Determining collaborative practice behavior following the
introduction of an APP in arthritis care across diverse clinical
settings in Ontario: Lundon K, Shupak R, Lineker S, Schneider
R, Passalent L, Sinclair L, Kennedy C. Canadian Initiative for
Outcomes in Rheumatology Care (49,898 2010-2011)
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 197
Faculty
Dr. Golda Milo-Manson,
Vice President,
Medicine & Academic Affairs
Physician Directors
Dr. Peter Rumney,
Rehabilitation & Complex
Continuing Care
Dr. Darcy Fehlings,
Child Development Program
Dr. Rob Carmichael,
Chief of Dental Services
Staff Physicians
Dr. Evdokia Anagnostou
Dr. Doug Biggar
Dr. Ryan Hung
Dr. Elizabeth Jimenez
Dr. Anne Kawamura
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Jeff Kobayashi
Laura McAdam
Gilbert Miller
Angela Orsino
Jonathan Tolkin
Wendy Roberts
Holland Bloorview Kids Rehabilitation Hospital
Holland Bloorview Kids Rehabilitation Hospital AFP (9.5 FTEs)
Year 2009-10
Active consulting staff = 17 subspecialists
Neurology................................................................112 days
Paediatric RII............................................................397 days
Psychiatry..................................................................33 days
As a provincial facility, we see almost 7,000 children and
PM&R......................................................................149 days
youth on an outpatient basis, and we admit more than
Medical students.....................................................291 days
650 patients a year.
Developmental paediatric
Subspecialty residents........................................... 1013 days
Holland Bloorview offers both in-patient and outpatient
developmental and rehabilitation services to the children
TOTAL....................................................................1995 days
and families of greater Toronto and provides tertiary services
in paediatric rehabilitation to the Province of Ontario.
Fellows/Residents Developmental Paediatric 2009/10
Dr. Michal Begin
Highlights
Dr. Joelene Huber
Dr. Nirit Brosh
тАв Fifth Annual Roszel Developmental Paediatric Resident
Research Day, February 19, 2010
тАв Child Development Update Conference, November 13, 2009
Dr. Elizabeth Young
Dr. Melissa Carter
Dr. Andrea Garbutt
Medical Education Chair:
For the academic accomplishments, please see the
Dr. Golda Milo-Manson
Division of Developmental Paediatrics report.
Developmental Paediatric Residency Program Director:
Dr. Anne Kawamura
Resident Coordinators:
Dr. Laura McAdam and Dr. Elizabeth Jimenez
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 199
Director
Dr. David Grant
Director, Stem Cell
and Regenerative
Medicine Initiatives:
Freda Miller
Director, Clinical
Programs
Wanda Schoonheyt
Primary Transplant
Physician Team
Dr. Upton Allen
Dr. Yaron Avitzur
Dr. Anne Dipchand
Dr. Hartmut Grasemann
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Elizabeth Harvey
Diane Hebert
Nicola Jones
Binita Kamath
Paul Kantor
Valarie Langlois
Dr.
Dr.
Dr.
Dr.
Dr.
Dr.
Simon Ling
Seema Mital
Vicky Ng
Rulan Parekh
Lisa Robinson
Mindy Solomon
Transplant Centre
Centre Overview
International Intestine Transplant Society
Clinical Care. SickKidsтАЩ Transplant CentreтАЩs portfolio includes
David Grant, Past President
the heart, intestine, kidney, liver, and lung solid organ
transplant programs; and the Group for Improvement of
Canadian Blood Services Transplant Expert Working Group
Intestinal Failure and Treatment (GIFT) program. We have
David Grant, Member
one of the largest clinical paediatric solid organ transplant
programs in North America, with more than 1,000 children
Canadian Society of Transplantation
who have received a solid organ graft, and a world-class
David Grant, Board member
academic intestinal failure program. Our case volumes and
Alison Drabble, Board member and Chair,
clinical outcomes rank within the top five to 10 per cent of
Associate Members Committee
centres in North America. Within a family-centred model, we
deliver cutting-edge treatment of end-stage organ failure from
Studies of Pediatric Liver Transplantation
the fetal stage through to the teenage years. Patient care
SPLIT- Vicky Ng Co-Chair Research Committee
is enhanced by dedicated health care workers who specialize
in the treatment of organ failure and transplantation;
David Foster Foundation
interdisciplinary educational programs; medical fellowships;
Anne Dipchand, Medical Director
and active basic, translational, and clinical research programs.
Research. In the 2009-2010 academic year, an inventory of
Education and Advocacy. The publication of the April 2010
the research awards by our interdisciplinary, medical and
issue of the Pediatric Clinics of North America, co-edited
surgical team identified more than $6,186,418 in total funding
by Vicky Ng, prominently featured many of our solid organ
and 37 related publications associated with Transplant
transplant programs, raising awareness about our excellent
Centre-related academic activities. Our innovative research
long-term outcomes of transplantation and strengthening our
programs are collectively aimed at advancing what Leroy Hood
already strong international profile. Our team continues to
(http://www.systemsbiology.org) describes as the P-4 future
advocate for paediatric solid organ transplant recipients
of medicine: predictive, preventative, personalized and
through strong representation on provincial, national and
participatory medical care. Important clinical, translational,
international committees.
and basic research foci within the Transplant Centre that are
supported by extramural funding include: a) vaccination
The table below highlights some of the leadership roles from
strategies; prevention of Epstein-Barr virus and Respiratory
our Transplant Centre constituency:
Syncytial virus complications post-transplantation (Upton Allen,
Infectious Diseases); b) health-related quality of life following
International Pediatric Lung Transplant Committee
solid organ transplantation (Stacey Pollock, Research
Mindy Solomon, Board member
Associate); c) xenotransplantation (David Grant, Executive
Director and Thomas Waddell, Orthopaedics); d) adolescent
International Pediatric Transplant Association
issues related to the transition to adult care (Miriam Kaufman,
Anne Dipchand and Upton Allen, Councilors
Adolescent Medicine); e) techniques to enhance lung recovery
for transplantation (Shaf Keshavjee, Respiratory Medicine,
Trillium Gift of Life
UHN); f) industry supported trials of immune suppression and
Diane Hebert, Board member
medical adherence (Diane Hebert, Nephrology and Stacey
Anne Dipchand, Medical Co-Director
Pollock); immune suppressive drug metabolism (Gideon Koren,
Clinical Pharmacology); g) leukocyte trafficking in autoimmune
Canadian Liver Transplant Study Group
kidney disease and kidney allograft rejection (Lisa Robinson,
David Grant, President
Nephrology); h) trials of modified lipid solutions to treat liver
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 201
failure associated with parenteral nutrition (Paul Wales,
General Surgery); and i) bladder regeneration research (Walid
Farhat). We are also contributing patients and leadership to
highly competitive, extramurally-funded clinical trials supported
by the leading granting agencies that include studies of: a)
liver failure and transplantation (National Institutes of Health
- Vicky Ng, Binita Kamath); b) heart transplantation (National
Institutes of Health - Anne Dipchand); c) intestinal failure
(National Institutes of Health - Paul Wales); and d) the role
of Epstein-Barr virus infections in post-transplant
lymphoproliferative disease (Canadian Institutes of Health
Research - Upton Allen).
During the 2009-2010 academic term, funds raised by the
Transplant Centre were used to support a number of new
initiatives. First, the Transplant Centre provided seed funding
for five transplant-related medical and interdisciplinary research
projects that will enhance patient care and generate pilot data
for extramural grant applications. Second, the TC supported
an initiative led by Seema Mital and colleagues, in close
collaboration with The Labatt Family Heart Centre, to establish
a Transplant BioBank which substantially improves our
competitiveness for translational and clinical research funding.
One of the Transplant CentreтАЩs long-term goals is to build
internal capacity to successfully undertake innovative clinical
trials using stem cell and/or regenerative medicine-based
therapies. To this end, the Transplant Centre supported two
separate projects demonstrating our commitment to innovation
in stem cell and regenerative research. Sevan Hopyan is
leading a limb regeneration study; while Martin Post, Tom
Waddell, and Janet Rossant are collaborators on a project on
lung regeneration. The Transplant Centre also supported the
initiation of a successful Stem Cell and Regenerative Medicine
seminar series, led by Freda Miller and colleagues. It will be
expanded in 2010-2011.
202
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
тАЬ
The most important single ingredient
in the formula of success is knowing
how to get along with people.
тАЭ
Theodore Roosevelt
Paediatric Housestaff
CHIEF RESIDENTS тАУ PGY4s
Dr. Alene Toulany
Dr. Gordon Soon
ASSOCIATE CHIEF RESIDENTS тАУ
PGY4s
Dr. Fahed Aljaser
Dr. Kesete Bezu
Dr. Avram Denburg
Dr. Caroline McLaughlin
Dr. Edward Pugh
Dr. Gagan Saund
Dr. Sarah Schwartz
204
THIRD YEAR RESIDENTS тАУ PGY3s
Dr. Joyce Ching
Dr. Leila Fazeli
Dr. Silvio Gonzalez
Dr. Andrea Hoffman
Dr. Emilie Jean-St-Michel
Dr. Julie Johnstone
Dr. Rae Koffman
Dr. Dina Kulik
Dr. Paola Luca
Dr. Dianne Lim
Dr. Katie Mennie
Dr. Niraj Mistry
Dr. Reem Mohammed
Dr. Nikhil Pai
Dr. Taso Papadopoulos
Dr. Cynthia Popalis
Dr. Alisa Rachlis
Dr. Deena Savlov
Dr. Audrey Segal
Dr. Maher Shalabi
Dr. Shawna Silver
Dr. Jennifer Smith
Dr. Anita Villani
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
SECOND YEAR RESIDENTS тАУ PGY2s
Dr. Raghad Al-Abdwani
Dr. Salman Al-Khalifa
Dr. Sundeep Bola
Dr. Melissa Chan
Dr. Sylvia Cheng
Dr. Jackie Chiang
Dr. Lindsey Craw
Dr. Amy French
Dr. Kate Houston
Dr. Luke Jagiello
Dr. Mikhael Katz-Lavigne
Dr. Shannon Knights
Dr. Eric Koelink
Dr. Charles Larson
Dr. Ripudaman Minhas
Dr. Amit Mukerji
Dr. Zoe Nugent
Dr. Melanie Penner
Dr. Maian Roifman
Dr. Natasha Saunders
Dr. Navneet Sharma
Dr. Catalina Tamayo
FIRST YEAR RESIDENTS тАУ PGY1s
Dr. Khaled Ali
Dr. Aly Aziz (Neuro)
Dr. Allison Bahm
Dr. Sanjuka Basak
Dr. Jack Brzezinski
Dr. Justine Cohen-Silver
Dr. Shirmee Doshi
Dr. Kamal Eltobgy
Dr. Mariel Heller
Dr. Jaideep Kanungo
Dr. Celine Kim
Dr. Chana Korenblum
Dr. Sarah Kwon
Dr. James Leung
Dr. Kandice Mah
Dr. Ashley Morris
Dr. Sonia Menard
Dr. Laila Nurmohamed
Dr. Evelyn Rozenblyum
Dr. Neha Sharma
Dr. Shayan Somani
Dr. Chengning Wang
Paediatric Grand Rounds
The Department of Paediatrics Grand Rounds series in
Schachar of SickKids Department of Psychiatry gave his
the 2009-2010 academic year once again involved a
insights into тАЬADHD: A cognitive neurosciences approach to
stimulating, vibrant series of presentations of interest to
a clinical problem.тАЭ Dr. Ben Alman of SickKids Orthopedic
the broad audience of SickKids faculty, post-graduate trainees,
Surgery, gave a fascinating discussion on тАЬCutting the roots:
students and community paediatricians. The general aim is
Can we cure sarcomas by understanding stem cells?тАЭ, and
to bring eminent child-health clinicians, scientists, and medical
Dr. Vito Forte, SickKids Chief of Otolaryngology, gave an
educators to Sick Kids to present state-of-the-art reviews of
entertaining outline of the management of paediatric stridor.
the latest research of relevance to child health. All presentations
highlight the link between тАЬbench and bedside,тАЭ demonstrating
Once again this year, our own faculty delivered outstanding
how new scientific advances translate into the best health care
presentations, including Drs. Chris Parshuram (тАЬIdentifying
for children.
Hospitalized Children at Risk: A Program of ResearchтАЭ), Miriam
Kaufman (тАЬTools for TransitionтАЭ), Eyal Grunebaum (тАЬAdvances
The 2009 Robert H.A. Haslam Lecture was delivered by
in the Treatment of Severe Combined Immune DeficiencyтАЭ),
Dr. Gabrielle DeVeber on тАЬStroke: Recent Insights from an
Debra Katzman (тАЬEating disorders in children and younger
Emerging Field.тАЭ Dr. Lorelei Lingard of our Learning Institute
adolescents: Current issues and unanswered questionsтАЭ),
presented a provocative talk on тАЬCollective competence?:
Moshe Ipp (тАЬWhen Town meets GownтАЭ), Seema Mital
Rethinking the discourse of competence in the context of
(тАЬPersonalized medicine: Have we come full circle?тАЭ) and
teamwork.тАЭ Dr. Noralou Roos of the University of Manitoba
Uri Tabori (тАЬTelomere maintenance in pediatric cancers:
delivered her thoughtful 2009 Harry Bain Lecture, тАЬSocial
Personalized medicine for individuals, tumors and cellsтАж.тАЭ).
Risk Assessment.тАЭ Dr. Jeffrey Maisels, Chair of Pediatrics,
Dr. Sheila Weitzman in her Burton Lecture addressed Acute
William Beaumont School of Medicine, Royal Oak, MI, was
Lymphoblastic Leukemia for the paediatrician: What do your
invited to give the 2009 Barry Smith Lecture. He delivered
patients want you to know? Dr. Norman Rosenblum gave a
an authoritative presentation entitled тАЬHyperbilrubinemia and
superb annual Paediatric Update lecture on тАЬThe malformed
Kernicterus: Not gone and not forgotten.тАЭ Dr. Malcolm Sears
kidney: What is wrong and what are we to do?тАЭ Dr. Gideon
of McMaster University in Hamilton delivered a cutting-edge
Koren celebrated the 25th anniversary of the Motherisk
lecture on тАЬPediatric Antecedents of Adult Asthma.тАЭ A highlight
program by reviewing several of its most important findings. A
was the presentation by Dr. Zulfiqar Bhutta, Chair, Department
variety of other high-quality talks enriched the yearтАЩs schedule.
of Paediatrics and Child Health, Aga Khan University, Karachi,
Pakistan on the occasion of Global Child Health Day, reviewing:
тАЬChildhood pneumonia in developing countries: challenges and
Grand Rounds will continue to be held on Wednesdays from
9:00 a.m. to 10:00 a.m. in the Daniels Hollywood Theatre
opportunities.тАЭ
at SickKids. The Department of Paediatrics Grand Rounds
Dr. Kaveh Shojania, Director, University of Toronto Centre
of the following: The Paediatric Executive Committee, Valerie
for Patient Safety, reminded us that we should be тАЬKeeping
Daniels, Department of Paediatrics, and Frank Ferrari and Sam
the possibility of error on your differential diagnosis: Patient
Mendolia from the Audio-Visual Department at SickKids.
Committee would like to acknowledge the help and support
safety in everyday practiceтАЭ. Dr. Robin Steinhorn of ChildrenтАЩs
Memorial Hospital, Chicago, spoke eloquently about
тАЬPersistent Pulmonary Hypertension of the Newborn: Radical
Thoughts about Oxygen.тАЭ Dr. Baruch Wollach of the Meir
Hospital, Israel gave the 2009 Bernard Laski Lecture on
тАЬNeutrophils: Giants in our Fight against InfectionтАЭ. Discussions
were provided by Dr. D. Brent Polk, Vanderbilt ChildrenтАЩs
Hospital, on тАЬProbiotics for health and diseases prevention will our past be our future?тАЭ and by Dr. Jane L. Burns, Seattle
ChildrenтАЩs, on тАЬManagement of CF Airway Infections.тАЭ Russell
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 205
2009
September 16 тАУ Dr. Brent Polk, Pediatric GI/Hepatology/
July 1 тАУ Holiday
Nutrition, Vanderbilt ChildrenтАЩs Hospital, Nashville, TN:
Probiotics for health and diseases prevention тАУ will our past
July 8 тАУ Dr. Keith Ooi, Dr. Juan Ossa, Division of
be our future?
Gastroenterology, Hepatology, and Nutrition: Paediatric
liver transplantation: Looking back to guide the future
September 23 тАУ Dr. Jane L. Burns, Clinical Director, Infectious
Disease, Seattle ChildrenтАЩs Research Institute, WA:
July 15 тАУ Dr. Abigail Harrison-Kong, Adolescent Medicine:
Management of CF airway infections
Sex, Drugs and OMG!
September 30 тАУ Dr. Gabrielle DeVeber, Division of Neurology,
July 22 тАУ Dr. Joelene Huber, Dr. Michael Begin, Developmental
SickKids: Haslam Lecture: Stroke: Recent insights from an
Paediatrics: The effects of TV/DVDs on early development:
emerging field
Mickey Mouse science or valid concern?
October 7 тАУ Dr. Lorelei Lingard, SickKids Learning Institute:
July 29 тАУ Drs. Glenda Bendiak, Fiona Kritzinger, Connie Yang,
Collective competence?: Rethinking the discourse of competence
Respiratory Medicine: When itтАЩs not asthma
in the context of teamwork
August 5 тАУ Dr. Nicholas Blanchette, Dr. Tania Cellucci,
October 14 тАУ Dr. Chris Parshuram, Critical Care Medicine,
Dr. Boris Hugle, Division of Rheumatology: Playing with fire:
SickKids: Identifying hospitalized children at risk: A program
An approach to periodic fever syndromes
of research
August 12 тАУ Dr. Alejandro Floh, Dr. Briseida Mema, Division
October 21 тАУ Dr. Noralou Roos, Professor, Community Health
of Critical Care Medicine: Surviving sepsis: The good, the bad,
Sciences, University of Manitoba, Founding Director, Manitoba
and the ugly...
Centre for Health Policy: Bain Lecture: Social risk assessment
August 19 тАУ Dr. Patricia Li, Dr. Gita Wahi, Division of Paediatric
October 28 тАУ Dr. Baruch Wollach, Head of Pediatrics and
Medicine: A new home: Caring for refugee children in Toronto
Pediatric Hematology/Oncology, Meir Hospital, Israel: Bernard
Laski Lecture: Neutrophils: Giants in our fight against infection
August 26 тАУ Dr. Nadya Ben Fadel, Dr. Mohit Sahni, Dr. Jennifer
Young, Division of Neonatology: What is тАШHotтАЩ (actually тАШCoolтАЩ)
November 4 тАУ Dr. Eyal Grunebaum, Immunology and Allergy,
in the management of hypoxic ischaemic encephalopathy of
SickKids: Advances in the treatment of severe combined
the newborn
immune deficiency
September 2 тАУ Cancelled
November 11 тАУ Dr. James Dwyer, Bioethics, SUNY, Syracuse,
NY: Bioethics Lecture: Obesity and responsibility
September 9 тАУ Dr. Miriam Kauman, Adolescent Medicine,
SickKids: Tools for transition
November 18 тАУ Dr. Debra Katzman, Division Head, Adolescent
Medicine, SickKids: Eating disorders in children and younger
adolescents: Current issues and unanswered questions
206
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
November 25 тАУ Dr. Ciaran Duffy, Rheumatology, McGill
February 3 тАУ Dr. Denis Daneman, Paediatrician-in-Chief,
University: Outcomes in JIA
SickKids: Publish and perish: The plague of plagiarism
December 2 тАУ Dr. Robin Steinhorn, Raymond and Hazel Speck
February 10 тАУ Dr. Kavesh Shojania, Director, University of
Berry, Professor of Pediatrics, Vice Chair of Pediatrics, Division
Toronto Centre for Patient Safety, Canadian Research Chair in
Head, Neonatology, ChildrenтАЩs Memorial Hospital, Chicago, IL:
Patient Safety and Quality Improvement, Associate Professor
Persistent pulmonary hypertension of the newborn: Radical
of Medicine, University of Toronto, Sunnybrook Health Sciences
thoughts about oxygen
Centre: Keeping the possibility of error on your differential
diagnosis: Patient safety in everyday practice
December 9 тАУ Dr. Moshe Ipp, Paediatric Medicine, SickKids:
When town meets gown
February 17 тАУ Dr. Russell Schachar, TD Bank Chair in
Child & Adolescent Psychiatry, SickKids: ADHD: A cognitive
December 16 тАУ Holiday skits
December 23 тАУ No Rounds
neurosciences approach to a clinical problem
February 24 тАУ Dr. Seema Mita, Staff Cardiologist, SickKids,
Associate Professor of Paediatrics, Roma and Marvin Auerback
December 30 тАУ No Rounds
Professor of Developmental Biology and Congenital Heart
Research: Personalized medicine: Have we come full circle?
2010
January 6 тАУ Dr. Jeffrey Maisels, Physician-in-Chief, Beaumont
March 3 тАУ Dr. Kevin Eva, Associate Professor, Department
ChildrenтАЩs Hospital, Professor and Chair, Department of
of Clinical Epidemiology and Biostatistics and Program for
Paediatrics, Oakland University, William Beaumont School of
Educational Research and Development, McMaster University:
Medicine, Royal Oak, MI: Hyperbilirubinemia and kernicterus:
Pediatric Update: On the value (and fallibility) of subjectivity in
Not gone and not forgotten
clinical and educational decision making
January 13 тАУ Dr. Malcolm Sears, Professor of Medicine,
March 10 тАУ Dr. Sheila Weitzman, Staff Physician,
McMaster University, Firestone Institute for Respiratory
Haematology/Oncology, SickKids: Burton Lecture: Acute
Health, AstraZeneca Chair In Respiratory Epidemiology,
Lymphoblastic Leukemia for the pediatrician: What do your
St. JosephтАЩs Healthcare, Hamilton, Ontario: Pediatric
patients want you to know?
antecedents of adult asthma
March 17 тАУ No Rounds, March Break
January 20 тАУ Dr. Charles Thornton, Professor of Neurology,
University of Rochester Medical Center, Rochester, NY:
March 24 тАУ Dr. Zulfiqar Bhutta, Professor and Chair,
JacobтАЩs Ladder: Developing treatment for myotonic dystrophy
Department of Paediatrics and Child Health, Aga Khan
January 27 тАУ Dr. Uri Tabori, Staff Physician, Haematology/
Childhood pneumonia in developing countries: Challenges
Oncology, SickKids: Telomere maintenance in pediatric cancers:
and opportunities
University, Karachi, Pakistan: Global Child Health Day:
Personalized medicine for individuals, tumours and cellsтАж
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 207
March 31 тАУ Dr. Clyde Hertzman, Professor, School of
May 5 тАУ Dr. Vito Forte, Otolaryngologist-in-Chief, SickKids:
Population and Public Health, University of British Columbia:
Pediatric stridor: Management
Achieving Health Equity for Kids: Monitoring protocols for early
and middle childhood embedded within the new Neuroscience
May 19 тАУ Dr. Gideon Koren, Director, Motherisk Program,
of experience-based brain development and life trajectory/
Professor of Paediatrics, Pharmacology And Genetics, Ivey
cumulative and latent risk
Chair in Molecular Toxicology: Motherisk Lecture: Treating
the mother тАУ Protecting the unborn тАУ 25 years of Motherisk
April 7 тАУ Dr. Massimo Zeviani, Besta National Institute
of Neurology, Milan, Italy: Barsky Lecture: Ethylmalonic
June 2 тАУ Dr. Talar Hopyanm, Department of Otolaryngology
encephalopathy
And the Program in Neurosciences and Mental Health:
April 14 тАУ Dr. Norman D. Rosenblum, Staff Nephrologist,
deaf children hear speech and music using cochlear implants
Sass-Kortsak Memorial Lecture: The sounds of silence: How
SickKids: Paediatric Update: The malformed kidney:
What is wrong and what are we to do?
June 9 тАУ AWARDS DAY
April 21 тАУ Dr. Ben Alman, Head, Orthopaedic Surgery,
June 23 тАУ Dr. John Bradley, Pediatric Infectious Disease,
SickKids: Cutting the roots: Can we cure sarcomas by
UCSD Hospital, San Diego, CA: The critical need to use
understanding stem cells?
antimicrobials wisely
April 28 тАУ Dr. Maximo Vento, Neonatal Research Unit,
University Hospital La Fe, Valencia, Spain: Barry Smith
Lecture: Titrating oxygen needs in the very preterm baby
immediately after birth
208
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Promotions/Recognition
Promoted to Professor of Paediatrics
Those who reached normal retirement age
Dr. Edgar Jaeggi
The following reached normal retirement age in June of 2010:
Dr. Nicola Jones
Dr. Allan Coates
Promoted to Associate Professor
of Paediatrics
Dr. Stephen Comay
Dr. Oussama Abla
Dr. Jonathan Hellmann
Dr. Ute Bartels
Dr. James Hilton
Dr. Susanne Benseler
Dr. Anna Jarvis
Dr. Mark Greenberg
Dr. Sharon Dell
Dr. Adam Dubrowski
25 Years of Service Awards
Dr. Adam Gassas
The following were honoured for their 25 years of service
Dr. Astrid Guttmann
to The Hospital for Sick Children in June of 2010:
Dr. Tilman Humpl
Dr. Simon Ling
Dr. John Freedman
Dr. Melinda Solomon
Dr. Ann Jefferies
Dr. Michael Weinstein
Dr. Ron Laxer
Dr. Aubrey Maze
Dr. Earl Silverman
Dr. Harold Sturm
Dr. Suzanne Schuh
Dr. Joseph Telch
Dr. Hilary Whyte
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 209
Awards
Teaching/Education Awards
Clinical Awards
Dr. Angela Punnett тАУ R.H.A. Haslam Preclerkship Teaching
Dr. Anne Griffiths тАУ Richard Rowe Award for Clinical
Award to the faculty member who has demonstrated excellence
Excellence in Paediatric Medical Care to the physician
in preclerkshop teaching
in the Department of Paediatrics who has demonstrated
Dr. Janet Saunderson тАУ The Lionel Weinstein Clerkship
sense over a significant period of time.
excellence in the delivery of clinical care in the broadest
Teaching Award to the faculty member who has demonstrated
excellence in clerkship teaching.
Dr. Elizabeth Donner тАУ Junior Faculty Award for Clinical
Excellence in Paediatric Medical Care to a physican within
Dr. Yehuda Nofech-Mozes тАУ The Undergraduate Community
the first 5-10 years of appointment to an Academic Health
Teaching Award in recognition of excellence in the teaching of
Sciences Centre, who has demonstrated excellence in the
medical students within community-based hospitals and offices.
delivery of clinical care.
Dr. Jeremy Friedman тАУ Harry Bain Award to a full-time member
Research Awards
of the Department of Paediatrics who has demonstrated
Dr. Peter Durie тАУ Physician Research Award for Career
excellence in teaching as nominated by core paediatric residents.
Excellence to recognize sustained excellence by a physician
Dr. Mark Feldman тАУ Marvin Gerstein Award to a part-time
specific field of study. The awardee will be more 15 or more
member of the Department of Paediatrics who has demonstrated
years beyond the initial date of appointment as a faculty
excellence in teaching as nominated by core paediatric residents.
member in an Academic Health Sciences Centre. This award
who has generated a body of work with relevance beyond a
was first awarded in 2005.
Dr. Marvin Gans тАУ Postgraduate Community Teaching Award
in recognition of excellence in the teaching of paediatric
Dr. Astrid Guttman тАУ Junior Faculty Research Award to
residents within community-based hospitals and offices.
recognize outstanding achievements and progress in research
by a physician during the first six years after his/her initial
Dr. Shirley Tse тАУ PERLs Award (Paediatric Educational Resident
academic appointment and whose primary appointment is in
Lecture Series Award) to the faculty member who
the Department of Paediatrics, University of Toronto. This
has demonstrated commitment to excellence in teaching
award was first awarded in 2005.
at the Paediatric academic sessions.
Paediatric Administrative Award
Dr. Roberto Mendoza тАУ Subspecialty Teaching Award to the
Ms. Deborah Taylor тАУ In recognition of an administrative
faculty member who has demonstrated commitment to excellence
support staff member in the Department of Paediatrics who
in teaching the subspecialty residents and clinical fellows.
has demonstrated outstanding performance and excellence in
all aspects of their role. This individual possesses outstanding
Dr. Anna Jarvis, Dr. David Chitayat тАУ Continuing Medical
communication and interpersonal skills and is motivated to
Education Award to the faculty member who has demonstrated
perform above and beyond their daily responsibilities. This
excellence in course coordination or teaching in a Department
award was first awarded in 2007.
of Paediatrics/University of Toronto Continuing Education
sponsored event.
210
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
тАЬ
The greatest discovery of
our generation is that human
beings can alter their lives by
altering their attitudes of mind.
As you think, so shall you be.
тАЭ
William James
Resident and Fellow Awards and Achievements
Teaching/Education Awards
Clinical Awards
Dr. Julie Johnstone (PGY3), Dr. Gordon Soon (PGY4),
Dr. Anastasios Papadopoulos тАУ The Saunders Prize
Dr. Al├иne Toulany (PGY4) тАУ Christopher Ondaatje
to a senior resident who has demonstrated excellence
Award to a senior resident for excellence in clinical
in clinical paediatrics.
teaching as nominated by core paediatric residents.
Research Awards тАУ core paediatrics
CanMEDS Award тАУ Subspecialty Trainee
Dr. John Brandsema тАУ 1st Place, Core Paediatrics
Dr. Elaine Goh
Dr. Alene Toulany тАУ 2nd Place, Core Paediatrics
CanMEDS Award тАУ Core Paediatric Trainee
Research Awards тАУ Senior Trainee
Dr. Paolo Luca
Dr. Sumit Gupta тАУ 1st Place, Clinical Science
Dr. Keith Chee Ooi тАУ Tie 2nd Place, Clinical Science
PeRLS Teaching Award
Dr. Furqan Shaikh
Research Awards тАУ Senior Trainee
Dr. Brian Chung тАУ 1st Place, Basic Science
Dr. Paola Angelini тАУ 2nd Place, Basic Science
212
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Annual Resident and Fellow Research Day (June 3, 2009)
Oral Presentations
Villani, Anita, Core Paediatrics
Chen, Ian, Adolescent Medicine
Early Detection Strategies Reduce Cancer Mortality In Germline
Health Value & Self-Reported Quality of Health in Adolescents
TP53 Mutation Carriers in Li-Fraumeni Syndrome. A Villani,
With Renal Transplants. I Chen, M Kaufman, D Hebert
U Tabori, J Schiffman, A Shlien, H Druker, A Novokmet,
J Finlay, D Malkin
Chung, Brian, Clinical & Metabolic Genetics
Genome-wide Epigenetic Profiling Shows Evidence of Crosstalk
Poster Presentations
Between Histone Modications and DNA Methylation in Patients
Abed S, Paediatric Medicine
with the Intellectual Disability Syndrome Due to JARID1C
Proton pump inhibitors for treatment of gastroesophaleal reflux
Mutations. BHY Chung, D Grafodatskaya, DT Butcher, FE Abidi,
in children: a systematic review. S Abed, S Mahant
A Feigenbaum, G Yoon, A Schulze, D Chitayat, J Vincent, CE
Schwartz, SW Scherer, R Weksberg
Ahmad, Syed Amir, Emergency Medicine
The effect of a novel restructuring of the Pediatric Emergency
Li, Patricia, Paediatric Medicine
Department. A Ahmad, K Chan, J Pirie
A Population-Based Study on the Association of Standardized
Protocols in the Emergency Department with Asthma Care
Ahorro, Jean Marie, Neurology
Outcomes in Ontario Children. P Li, T To, P Parkin, G Anderson,
Viral seroprevalence among Canadian children presenting with
K Lam, A Guttmann
acquired demyelination of the central nervous system. J Ahorro,
B Banwell, R Tellier, M McGowan, S Magalhaes, D Arnold, AD
Mahmut, Naila, Cardiology
Sadovnick, A Bar-Or, on behalf of the Canadian Pediatric
Hypoxia Induces Senescence of Human Embryonic Stem
Demyelinating Disease Network
Cells During Cardiac Differentiation. N Mahmut, M Niapour,
C Kinnear, U Tabori, G Keller, S Mital
Al-Abdulrazzaq, Fatoumah, Emergency Medicine
Mistry, Niraj, Core Paediatrics
wheezing. F Al-Abdulrazzaq, S Schuh
Infant distress during MDI vs nebulizer therapy for acute
Predictors of Prolonged Hospitalization in Pediatric Empyema
Treated with Chest Tube Insertion. N Mistry, E Cohen,
Alghamdi, Faisal, Emergency Medicine
S Mahant, DJ Rea, BL Connolly, M Weinstein
Which epidemiologic and statistical concepts should
pediatricians understand to be able to appraise the literature?
Morris, Shaun, Infectious Diseases
F Alghamdi, J Thull-Freedman
Neonatal and Childhood Mortality From Acute Respiratory
Infections in India: A Population Based Study. SK Morris,
Al Kalbani, Naifain, Nephrology
DG Bassani, M Kesler, AA Cohen, R Kumar, P Jha
Idiopathic hypercalcemia in infants with renal dysplasia.
N Al Kalabani, E Harvey, D Geary
Ooi, Keith Chee, Gastroenterology
Association Between Severity of CFTR Mutations and Risk
Alkhater, Reem, Neurology
of Pancreatitis. CY Ooi, K Keenan, R Dorfman, T Gonska,
Towards the identification of pediatric movement disorder
N Anderson, M Cipolli, C Castellani, R Durie
genes: a family with a new neurotransmitter disorder.
RA Alkhater, JJ Rilstone, BA Minassian
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 213
Alkon, Jaime, Cardiology
Begin, Michal, Developmental Paediatrics
The right ventricular systolic to diastolic duration ratio predicts
Prevalence of ADHD in children and adolescents with familial
functional capacity and survival in children with pulmonary
dysautonomia. M Begin, E Anagnostou, A Kawamura,
arterial hypertension. J Alkon, T Humpl, C Manlhiot,
R Schachar, I Berger, C Maayan
BW McCrindle, JT Reyes, MK Friedberg
Brandsema, John F, Neurology
Al-Ruwaili, Nahar, Emergency Medicine
Cerebral arteriopathy in children with Neurofibromatosis type 1.
Neonatal Mastitis тАУ Controversies in management.
D Rea, JF Bandsema, D Armstrong, PC Parkin, Gabrielle
N Al-Ruwaili, D Scolnik
deVeber, D MacGregor, WJ Logan, R Askalan
Al-Saleh, Ahmed, Emergency Medicine
Breakey, Vicky, Haematology/Oncology
Ascertainment of abuse related fractures at a childrenтАЩs
The quality of hemophilia information available on the internet.
Emergency Department. A Al-Saleh, Z Somji, A Plint, K Boutis
VR Breakey, D Ignas, V Blanchette
Amin, Reshma, Respiratory Medicine
Chaturvedi, Swasti, Nephrology
A pilot study of FDG-PET imaging to detect changes in airways
Collapsing FSGS and obsessive compulsive disorder:
inflammation in pediatric cystic fibrosis patients after
A possible link between the two diseases. S Chaturvedi,
treatment for a pulmonary exacerbation. R Amin, M Charron,
C De Souza, C Hahn, A Feingenbaum, V Langlois
L Grinblat, A Shammas, H Grasemann, F Ratjen
Ching, Joyce, Core Paediatrics
Appendino, Juan Pablo, Neurology
Renal dysfunction after liver transplantation in children:
The impact of amplitude integrated electroencephalography
Should we be concerned? JCY Ching, S Pollack, I Diamond,
on neonatal intensive care unit practice. JP Appendino,
A Wan, M De Angelis, N Jones, SC Ling, A Fecteau, VL Ng
P McNamara, M Keyzers, D Stephens, CD Hahn
Chong, Amy Lee, Haematology/Oncology
Ardelean, Daniela S, Rheumatology
Optic pathway gliomas in adolescence. AL Chong, E Bouffet,
Pediatric Takaysu arteritis: significance of central nervous
U Tabori, A Huang, U Bartels
system manifestations. DS Ardelean, R Schneider,
ED Silverman, R Laxer, M Seed, SJ Yoo, SM Benseler
Chung, Brian, Medical Genetics
Balma-Mena, Alexandra, Paediatric Medicine
A new insight into the pathogenesis of chondrodysplasia
The multifaceted subacute cutaneous lupus erythematosus.
punctata? BHY Chung, P Shannon, D Chitayat
De-Novo interstitial deletion at chromosome 5q15-21.1 тАУ
A Balma-Mena, N Ho
Courtney-Martin, Glenda, Gastroenterology
Bar-Yosef, Omer, Neurology
The addition of cysteine to the total sulphur amino acid
Relationship between MEG spike sources and fMRI language
requirement as methionine does not increase erythrocytes
patterns in children with epilepsy. O Bar-Yosef, H Otsubo,
glutathione synthesis in the TPN fed human neonate: A pilot
C Sylvester, D Morris, WJ Logan, EJ Donner
study. G Courtney-Martin, AM Moore, RO Ball, PB Pencharz
214
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Danayan, Karoon C, Rheumatology
Glatstein, Miguel, Emergency Medicine
Recurrence of neonatal lupus erythematosus in siblings.
Sulfonylurea ingestion. M Glatstein, D Scolnik, Y Finkelstein
KC Danayan, P Tyrrell, E Silverman
Gibson, Paul, Haematology/Oncology
Di Giovanni, Valeria, Nephrology
Acinic cell carcinoma: A restrospective review of the 10 year
The BMP receptor, ALK3, is required for urogenital
HSC experience. P Gibson, V Forte, GR Somers, N Laperriere,
development. V Di Giovanni, A Alday, Y Mishina, ND Rosenblum
R Grant
Djokanovic, Nada, Clinical Pharmacology and Toxicology
Goh, Elaine, Clinical and Metabolic Genetics
Does treatment with bisphosphonates endanger the human
Autosomal dominant connective tissue disorder presenting
pregnancy? N Djokanovic, D Klieger-Grossman, G Koren
with short stature, clubfeet, sparse hair, hyperextensible joints,
Elango, Rajavel, Gastroenterology
E Goh, C Barnett, B Lee, A Hinek, D Chitayat
hernias and distinctive facial features тАУ a new syndrome?
Evidence that protein requirements in healthy school-age
children are significantly underestimated in current
Gupta, Sumit, Haematology/Oncology
recommendations. R Elango, MA Humayun, RO Ball,
Incidence and predictors of abandonment of therapy among
PB Pencharz
children with cancer in El Salvador: A prospective cohort study.
S Gupta, M Bonilla, N Rossell, C Salaverria, R Barr, A Sala,
El Sayed, Manal, Neonatology
ML Metzger, L Sung
Risks of recurrent low birth weight and preterm births:
Systemic review and meta-analyses. M El Sayed, V Shah,
Hang, Marissa, HaematologyтАЩOncology
PS Shah, Knowledge Synthesis Group
Predictors of age at onset of joint bleeding and
musculoskeletal burden in boys with severe Hemophilia A.
Faghfoury, Hanna, Clinical and Metabolic Genetics
M Hang, EM Pullenayegum, F Pluthero, P Hilliard, W Kahr, VS
Transient fulminant hepatitis in a patient with classical
Blanchette, BM Feldman
citrullinemia. H Faghfoury, A Schulze
Hashmi, Seema, Nephrology
Finen, Emer, Neonatology
A novel mutation in the gene for alanine-glyoxylate transferase
High-fidelity simulation may not be superior to traditional
as a cause of primary hyperoxaluria Type 1. S Hashmi,
Low-fidelity methods for neonatal Resuscitation training.
M LeMaire, C Licht, D Geary, E Harvey
E Finan, Z Bismilla, HE Whyte, V LeBlanc, PJ McNamara
Hawkes, Michael, Infectious Diseases
Garcia-Bournissen, Facundo, Clinical Pharmacology and
Malaria potentiates experimental mycobacterial infection
Toxicology
in vitro and in vivo. M Hawkes, L Xiaoming, M Crockett,
Prediction of infant drug exposure through breastfeeding:
A Diassiti, WC Liles, J Liu, KC Kain
Population PK modeling of fluoxetine. F Garcia-Bournissen,
A Panchaud, C Csajka, JH Kristensen, A Taddio, KF Ilett,
EJ Begg, S Ito
Hutchinson, Clare, Rheumatology
Long-term neurological outcome of children with biopsyconfirmed small vessel primary CNS vasculitis. C Hutchinson,
J Elbers, D Kwan, W Halliday, H Branson, S Laughin,
D Armstrong, C Hawkins, SM Benseler
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 215
Jain, Shailly, Medical Genetics
Kumar, Sathish, Rheumatology
A possible role for the PTPN11 gene in sex determination.
Clinical profile and predictive factors for symptomatic avascular
S Jain, M Thomas, J Jessen, S Keating, D Chitayat
necrosis in pediatric systemic lupus erythematosus (pSLE).
S Kumar, PN Tyrrell, SM Benseler, EA Harvey, D Hebert,
Jean-St-Michel, Emilie, Core Paediatrics
ED Silverman
Double blind randomized controlled crossover studies of the
effects of remote preconditioning on the exercise performance
Leahy, Timothy, Infectious Diseases
of elit swimmers. E Jean-St-Michel, C Manlhiot, B McCrindle,
Methicillin-resistant Staphylococcus aureus (MRSA) in a
G Wells, A Redington
paediatric cystic fibrosis (CF) clinic population: clinical and
molecular epidemiology, risk factors for colonization, and
Kam April, Emergency Medicine
impact on disease progression. TR Leahy, Y Yau, F Ratjen,
Telesimulation: A novel method of teaching EZ-IO insertion
M Corey, V Waters
from Toronto, Canada to Gabarone, Botswana, Africa.
A Mikrongianakis, A Kam, S Silver, A Okrainec, G Azzie
Lemaire, Mathieu, Gastroenterology
Dysnatremia in hospitalized pediatric patients prescribed
Kanbur, Nuray, Adolescent Medicine
total parenteral nutrition: a retrospective study. M Lemaire,
Frequency and pathophysiology of nocturnal enuresis in
P Pencharz, S Zlotkin, D Geary
adolescents with anorexia nervosa. N Kanbur, L Pinhas,
A Lorenzo, W Farhat, C Licht, DK Katzman
Li, Kayi, Paediatric Medicine
Khurshid, Faiza, Neonatology
the primary care practice setting: A TARget Kids! Study. K Li,
Theraputic hypothermia (TH) for hypoxic ischemic
C Birken, J Maguire, M Mekky, L Burr, D OтАЩConnor, B Chisamore,
encephalopathy (HIE): Are we cooling eligible neonates?
E Lau, P Parkin
Measuring nutrition risk in young preschool-aged children in
F Khurshid, W Mak, PJ NcNamara, H Whyte, K-S Lee
Li, Patricia, Paediatric Medicine
Kim, Vy HD, Immunology/Allergy
A population-based study on the effect of clinical practice
Omenn syndrome: A phenotype of severe combined
guidelines in the Emergency Department on childhood asthma
immunodeficiency. VHD Kim, E Grunebaum CM Roifman
admissions and bouncebacks in Ontario, Canada. P Li, T To,
P Parkin, G Anderson, A Guttmann
Klieger-Grossmann, Chagit, Clinical Pharmacology
and Toxicology
Lim, Siok Hoon, Rheumatology
In-utero exposure to ionizing radiation in a woman
Early recognition of juvenile systemic lupus erythematosus
with HodgkinтАЩs lymphoma тАУ A case report and a review
(JSLE) patients at risk for poor long term bone outcome.
of the literature. C Klieger-Grossmann, N Djokanovic,
SH Lim, SM Benseler, P Tyrrell, M Charron, E Silverman,
G Koren, D Chitayat
Makhani, Naila, Neurology
Kulik, Dina, Core Paediatrics
Cyclophosphamide therapy in pediatric multiple sclerosis.
Quality of life in childhood epilepsy: What is the level of
N Makhani, MP Gorman, HM Branson, L Stazzone, BL Banwell,
agreement between youth and their parents? DM Kulik,
T Chitnis
LH Verhey, GM Ronen, P Rosenblum, L Lach, DL Streiner,
Canadian Pediatric Epilepsy Network
216
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
Mohamed, Adel, Neonatology
Radhakrishnan, Seetha, Nephrology
Comparison of infant pain responses between two different
Use of DDAVP in renal failure. S Radhakrishnan, B Connollly,
methods of urine collection for diagnosis of infection:
J Chuan, V Langlois
suprapubic aspiration and urinary catheterization. A Mohamed,
W El Naggar, A Yui, V Shah, J Manley, P McNamara, A Taddio
Sen, Saswati, Haematology/Oncology
The Mechanism of erythropoitic failure caused by loss of the
Mokhtari, Reza Bayat, Haematology/Oncology
inherited aplastic anemia-related gene, SBDS. S Sen, H Wang,
Epigenetic modulation of neuroblastoma: growth and
S-L Adams, K Zhou, Y Dror
metastasis. RB Mokhtari, S Barchel, G Koren, H Yeger
Shaikh, Furqan, Haematology/Oncology
Nahum, Amit, Immunology and Allergy
Progressive transformation of germinal centers: An intriguing
Association of the lymphoid tyrosine phosphatase, LYP, R620W
cause of lymphadenopathy in children. F Shaikh, S Alexander,
variant, with chronic mucocutaneous candidiasis. A Nahum,
B Ngan, RM Grant
A Bates, N Sharfe, CM Roifman
Sharma, Navneet, Paediatric Medicine
Nasef, Nehad, Neonatology
Prevalence of microcytic anemia in children 12 - 38 months
Toxicity for light-exposed TPN solutions: Potential roles for
of age assessed by Suspected Child Abuse and Neglect team
ascorbate (Vit C) and selenium. N Nasef, R Belcastro, A Nach,
at The Hospital for Sick Children. N Sharma, M Shouldice,
C Kantores, AK Tanswell, RP Jankov
D Mekky, P Parkin
OтАЩGorman, Clodagh, Endocrinology
Shulman, Rayzel, Endocrinology
Sleep disordered breathing in patients with craniopharyngioma
A systemic review and meta-analysis of the effects of
and hypothalamic obesity. C OтАЩGorman, J Simoneau-Roy,
telemedicine interventions for Type 1 Diabetes in children
J MacFarlane, I MacLusky, D Daneman, J Hamilton
and adolescents. R Shulman, C OтАЩGorman, MR Palmert
Parakh, Manish, Neurology
Smile, Sharon, Developmental Paediatrics
A study attempting to evaluate the usefulness of normal
The nosology of attention deficit hyperactive disorder in autism.
evoked potentials in predicting non pogressive childhood
S Smile, J Brian, W Roberts,A Dupuis
neurologic disorders. M Parakh
So, Joyce, Clinical and Metabolic Genetics
Principi, Tania, Emergency Medicine
The Opitz syndrome-associated protein MID1 and the tumour
What happens to oxygen saturation after discharge in
suppressor CYLD interact and have antagonist effects at the
outpatients with acute bronchiolitis? T Principi, A Coates,
microtubules. J So, A Wilde, S Schweiger
P Parkin, D Stevens, Z Da Silva, S Schuh
Sonnenberg, Lyn, Developmental Paediatrics (withdrawn)
Radhakrishnan, Dhenuka, Respiratory Medicine
Preschool traumatic brain injury and its affect on social
A comparison of mortality trends in school-aged children with
development at eight years of age. LK Sonnenberg, A Dupuis,
and without asthma. D Radhakrishnan, J Guan, C Wang,
PG Rumney
A Gershon, S Dell, T To
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT 217
Tanaka, Toshihiro, Clinical Pharmacology and Toxicology
Walsh, Catherine M, Gastroenterology
Transmission of Hepatitis C virus infection during
Concurrent versus terminal feedback: Does the timing of
breastfeeding: A meta-analysis. T Tanaka, C Tam,
feedback matter? CM Walsh, SC Ling, CS Wang, H Carnahan
I Goh, H Tan, C Lee, M Moretti, S Ito
Xu, Emily, Neonatology
Thampi, Nisha, Core Paediatrics
Rho-kinase (ROCK) inhibitor reverses vascular remodeling and
Children with tuberculosis who deteriorate on anti-tuberculous
cardiac dysfunction in neonatal rats with chronic pulmonary
therapy: A case series. N Thampi, IC Kitai
hypertension (PHT). EZ Xu, PJ McNamara, C Kantores,
J Ivanovska, RP Jankov
Tsangaris, Elena, Haematology/Oncology
Genetic analysis of inherited bone marrow failure syndromes
Yazdani-Brojeni, Parvaneh, Clinical Pharmacology
from one comprehensive cohort of patients. E Tsangaris,
and Toxicology
R Klaassen, CV Fernandez, R Yanofsky, E Scherek,
Determination of quetiapine in human breast milk.
J Champagne, M Silva, JH Lipton, J Brossard, Y Samson,
P Yazdani-Brojeni, N Taguchi, M Moretti, G Koren, S Ito
S Abish, M Steele, K Ali, N Dower, U Athale, L Jardine, JP Hand,
D Stephen, I Odame, P Canning, C Allen, J Beyene, Y Dror
Yi, Man, Neonatology
Vala, Snehal, Emergency Medicine
contributing to lung injury in neonatal rats. M Yi, R Balcastro,
Clinical practice guideline for battery ingestion. S Vala,
S Shek, A Masood, A Ziino, B-H Johnson, C Kantores,
A Ahmad, J Thull-Freedman
RP Jankov, AK Tanswell
Venkateswaran, Sunita, Neurology
Yiu, Eppie, Neurology
Characterization of serum inflammatory markers in pediatric
Tumefactive demyelination: Radiographic and clinical features
Inhibited physiological apoptosis as a novel pathway
acquired demyelinating syndromes of the central nervous
in a prospective cohort of children with an acquired
system. S Venkateswaran
demyelinating syndrome. E Yiu, L Verhey, S Laughlin,
H Branson, B Banwell
Vezmar, Marko, Cardiology
Percutaneous pulmonary valve implantation in the young:
Zolkipli, Zarazuela, Neurology
Medium term follow-up. M Vezmar, K-J Lee, R Chaturvedi,
Role of muscle carnitine deficiency in the myopathy of
C Almeida, D Manlhiot, B McCrindle, EM Horlick, L Benson
Duchenne Muscular Dystrophy (DMD). Z Zolkipli, L Mai,
A-M Lamhonwah, I Tein
Vyver, Ellie, Adolescent Medicine
Medical stability in children and adolescents with anorexia
Werner, Klaus, Neurology
nervosa: a retrospective review. E Vyver, S Grewal, L Pinhas,
Electroretinogram and developmental outcome of infantile
DK Katzman
spasms. KG Werner, M Cortez, T Wright, E Widjaja. S Weiss,
C Snead, E Donner, C Westall
Wahi, Gita, Paediatric Medicine
Active transportation for school aged children: Rates of
bicycling to school in an urban population. G Wahi, C Birken,
P Parkin
218
DEPARTMENT OF PAEDIATRICS 2009-10 ANNUAL REPORT
тАЬ
The golden rule is that
there are no golden rules.
тАЭ
George Bernard Shaw
Department of
Paediatrics
555 University Avenue
Toronto, ON, Canada M5G 1X8
www.sickkids.ca
Phone: 416.813.6122
For electronic versions of
Department of PaediatricsтАЩ
annual reports, please see
www.sickkids.ca/paediatrics
www.paeds.utoronto.ca

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