Fragment-based Drug Discovery Market

Transparency Market
Research
Fragment-based Drug Discovery Market Expected to Reach USD 1.2 Billion Globally in
2023
Published Date
14-Oct-2015
111 Page Report
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Radiopharmaceuticals Market
REPORT DESCRIPTION
Fragment-based Drug Discovery Market Expected to Reach USD 1.2 Billion Globally in 2023
The assurance of logical and efficient lead innovation has fuelled interest for fragment-based drug discovery (FBDD).
This enthusiasm is further complemented by a paradigm shift from conventional techniques like high-throughput
screening (HTS) towards design intensive approaches, enabled by computational and structural biology. Fragment-based
drug discovery utilizes comparatively small libraries of “fragments or ligands” that are of low-molecular weights. These
fragments are evaluated for binding affinity, then incrementally altered into more potent molecules against the biological
target(s) of interest. The major advantages of this technique that are expected to drive the popularity of FBDD among
pharmaceutical companies are less cost and time process, streamlined equipment operability, and higher success rates of
hits.
Major factors likely to boost the growth of the market are Simpler and less time consuming technique, streamlining and
easy access to advanced biophysical techniques could drive the market in the near future. However, lower level of potency
in few of the compounds derived from fragment screening and requirement of high protein and unique fragment library to
conduct studies would hamper the growth of the fragment-based drug discovery market during the forecast period.
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Fragment screening services and fragment optimization collectively form the fragment-based drug discovery market. Fragment
screening segment was further segmented into biophysical services and non-biophysical services. Biophysical services are further
segmented into techniques such as Nuclear Magnetic Resonance (NMR) Spectroscopy, Differential scanning Fluorimetry (DSF)
Assay (Thermal Shift), Fluorescence Polarization (FP), Isothermal Titration Calorimetry (ITC), X-ray Crystallography, Surface
Plasmon Resonance, Biolayer Interferometry, Mass Spectrometry, Capillary Electrophoresis, and others (biochemical assays). NMR
was the largest segment of the FBDD market, accounting for approximately 19.7% share in 2014. The technique is expected to
maintain its leadership position during the forecast period. Advantages of NMR such as high reliability, easy operability, and wide
versatility are likely to fuel the growth of the NMR segment. However, high procurement cost and availability of cheaper alternatives
could hamper market growth.
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Demand for fragment-based drug discovery is increasing in pharmaceutical companies, CROs, and academic & research institutions as
these procedures detect fragments with low affinity binding which is generally difficult to detect by most other methods. Based on
end-users the FBDD market has been segmented into biopharmaceutical companies, CROs, and academic and research institutions.
Among these, biopharmaceutical companies emerged as the major FBDD service user, accounting for 46.0% in 2014. Low
productivity, dwindling pipeline, and rising R&D costs are inducing biopharmaceutical companies to narrow down the gaps in the
current drug discovery processes, thereby boosting productivity and implementation of FBDD as drug discovery technique.
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Geographically, the fragment based drug discovery market has been segmented into North America, Europe, Asia Pacific, Latin
America, and Rest of the World. North America has been further segmented into the U.S. and Canada; Europe into Germany, the U.K.
and Rest of Europe; Asia Pacific into Australia, Japan, and Rest of Asia Pacific, Latin America into Brazil and Rest of Latin America,
and rest of the world. The market revenue of fragment based drug discovery services for each geographical region for 2014 and 2023
along with forecast from 2015 to 2023 in respective regions in terms of USD million, has been explained in the geography section of
the report.
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TABLE OF CONTENT
Chapter 1 Preface
1.1 Report Description
1.2 Market Segmentation
1.3 Research Methodology
1.4 Research Methodology: Assumptions
Chapter 2 Executive Summary
2.1 Global Fragment-based Drug Discovery Market, Estimates and Forecast, By Revenue, 2013–2023 (US$ Mn)
2.2 Global Fragment-based Drug Discovery Market Revenue, by Services, 2014 (US$ Mn)
2.3 Global Fragment-based Drug Discovery Market Revenue, by End-user, 2014 (US$ Mn)
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2.4 Global Market Share, by Geography, 2014 and 2023 (Value %)
2.5 Fragment-based Drug Discovery Market Snapshot
Chapter 3 Fragment-based Drug Discovery Market Overview
3.1 Introduction
3.1.1 Hit to Lead
3.1.2 Progression to Candidates from Fragment Leads
3.2 Event Impact Analysis
3.3 Future Trends and Developments
3.4 Market Drivers
3.4.1 Simpler and less time consuming technique
3.4.2 Streamlining and easy access to advanced biophysical techniques
3.5 Restraints
3.5.1 Lower level of potency in few of the compounds derived from fragment screening
3.5.2 Requirement of high protein and unique fragment library for conducting studies
3.6 Opportunities
3.6.1 Merging of computational biology with biophysical techniques
3.6.2 Emerging economies to offer sustained growth opportunities
3.7 Porter’s Five Forces Analysis
3.8 Recent Developments in Fragment-based Drug Discovery
3.9 Fragment-based Drug Discovery: Case Histories
3.10 Market Share – Fragment-based Drug Discovery Market (2014) (%)
3.11 Market Attractiveness Analysis – Fragment-based Drug Discovery Market
Chapter 4 Market Segmentation – By Services Component
4.1 Introduction
4.2 Comparative Analysis of FBDD and HTS
4.3 Global Fragment Screening Market Revenue for FBDD, 2013 – 2023 (US$ Mn)
4.3.1 Global Biophysical Techniques Market for FBDD (US$ Mn), 2013 – 2023)
4.3.1.1 Global NMR Spectroscopy Market Revenue for FBDD, 2013–2023 (US$ Mn)
4.3.1.2 Global DSF Assay Market Revenue for FBDD, 2013–2023 (US$ Mn)
4.3.1.3 Global Fluorescence Polarization (FP) Market Revenue for FBDD, 2013–2023 (US$ Mn)
4.3.1.4 Global Isothermal Titration Calorimetry (ITC) Market Revenue for FBDD, 2013–2023 (US$ Mn)
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4.3.1.5 Global X-ray Crystallography Market Revenue for FBDD, 2013–2023 (US$ Mn)
4.3.1.6 Global SPR Market Revenue for FBDD, 2013–2023 (US$ Mn)
4.3.1.7 Global Biolayer Interferometry Market Revenue for FBDD, 2013–2023 (US$ Mn)
4.3.1.8 Global Mass Spectrometry (MS) Market Revenue for FBDD, 2013–2023 (US$ Mn)
4.3.1.9 Global Capillary Electrophoresis (CE) Market Revenue for FBDD, 2013–2023 (US$ Mn)
4.3.1.10 Global Other (Biochemical Assays) Market Revenue for FBDD, 2013–2023 (US$ Mn)
4.3.2 Global Non-biophysical Techniques Market Revenue for FBDD, 2013–2023 (US$ Mn)
4.4 Global Fragment Optimization Market Revenue for FBDD, 2013–2023 (US$ Mn)
Chapter 5 Market Segmentation – By End-user
5.1 Introduction
5.2 Global Market for Fragment-based Drug Discovery in Biopharmaceutical Companies, 2013–2023 (US$ Mn)
5.3 Global Market for Fragment-based Drug Discovery in CROs, 2013–2023 (US$ Mn)
5.4 Global Market for Fragment-based Drug Discovery in Academic and Research Institutions, 2013–2023 (US$ Mn)
Chapter 6 Fragment-based Drug Discovery Market - Regional Analysis
6.1 Global Overview
6.2 North America Fragment-based Drug Discovery Market Overview
6.2.1 U.S. Fragment-based Drug Discovery Market Revenue, 2013 - 2023, (US$ Mn)
6.2.2 Canada Fragment-based Drug Discovery Market Revenue, 2013 – 2023, (US$ Mn)
6.3 Europe Fragment-based Drug Discovery Market Overview
6.3.1 Germany Fragment-based Drug Discovery Market Revenue, 2013 - 2023, (US$ Mn)
6.3.2 U.K. Fragment-based Drug Discovery Market Revenue, 2013 – 2023, (US$ Mn)
6.3.3 Rest of Europe Fragment-based Drug Discovery Market Revenue, 2013–2023 (US$ Mn)
6.4 Asia Pacific Fragment-based Drug Discovery Market Revenue, 2013–2023 (US$ Mn)
6.4.1 Japan Fragment-based Drug Discovery Market Revenue, 2013 - 2023, (US$ Mn)
6.4.2 Australia Fragment-based Drug Discovery Market Revenue, 2013 – 2023, (US$ Mn)
6.4.3 Rest of Asia Pacific Fragment-based Drug Discovery Market Revenue, 2013–2023 (US$ Mn)
6.5 LATAM Fragment-based Drug Discovery Market Revenue, 2013–2023 (US$ Mn)
6.5.1 Brazil Fragment-based Drug Discovery Market Revenue, 2013 - 2023, (US$ Mn)
6.5.2 Rest of LATAM Fragment-based Drug Discovery Market Revenue, 2013 – 2023, (US$ Mn)
6.6 RoW Fragment-based Drug Discovery Market Revenue, 2013–2023 (US$ Mn)
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Fragment-based Drug Discovery Market Expected to Reach USD 1.2 Billion Globally in 2023Fragment-based drug discovery has been recognized as a potential method to design novel molecules as this technique discovery utilizes comparatively small libraries of ‘fragments or ligands’ that are of low-molecular weights. Factors such as less time-consumption and easy access to biophysical fragment screening techniques are driving the growth of the global fragment-based drug discovery market. Know more http://goo.gl/jR0Jfz