Curriculum Vitae

Curriculum Vitae
1.
Name Surname: Ajda Çoker Gürkan
Contact information
Address: Istanbul Kultur University, Faculty of Science and Literature, Department of
Molecular Biology and Genetics, Atakoy Campus, 34156 Bakirkoy-Istanbul
Phone: +90 212 498 4565
E-mail: [email protected]
2.
Date of Birth: 1980
3.
Title: Assoc. Prof. Dr.
4.
Education:
Degree
Bachelor
Field
Science& Letters Faculty
University
Marmara University
Year
2002
Marmara University
2005
Marmara University
2009
Biology Department
Master
Institute of Science
Biology Department
Doctorate
Institute of Science
Biology Department
Page 1 of 15
5.
Academic Titles
Title
Assist.
Prof
Department
University
Year/Period
Molecular
Biology Istanbul Kultur February 2014
Research
Assistant
Molecular
Biologist
Molecular
Research
Assistant
and Genetics
University
November 2010
Biology Istanbul Kultur October 2008
and Genetics
University
August 2008
Biology Istanbul Kultur July 2008
and Genetics
University
February 2008
Engineering Faculty,
Marmara
January 2008
Molecular
Biology University
and
Culture
Cell
October 2003
Laboratuary
6.
Graduate Theses Supervised
Zeynep Akyol, İstanbul Kultur University, Molecular Biology and Genetics
Department
6.1 Master Theses
“Koroner Arter Hastalığı ile IL-1 Reseptör Antagonist Gen Polimorfizminin Moleküler
Düzeyde İncelenmesi” (Assist. Prof. Dr. Ahmet ARMAN, Marmara University, Faculty
of Science)
6.2 Doctorate Theses
“İnsan Büyüme Hormonunun (BH-N) klonlanıp, ekspresyonu ve İzole Büyüme Hormonu
Eksiliği Sendromunun Genetik Karakterizasyonu” (Assoc. Prof. Dr. Ahmet ARMAN,
Marmara University, Faculty of Science)
7.
Publications
7.1 Articles published in peer reviewed international journals
1.
E. D. Arisan, P. Obakan, A. Çoker-Gürkan, A. Calcabrini, E. Agostinelli, N. Palavan
Ünsal, “CDK inhibitors induce mitochondria-mediated apoptosis through the
activation of polyamine catabolic pathway in LNCaP, DU145 and PC3 prostate
cancer cells”. Current Pharmaceutical Design, 20: 180-188 (9), 2014 (Research
Article).
Page 2 of 15
2.
Ozfiliz P, Arisan ED, Coker A, Obakan P, Eralp T, Doganay-Dinler G, PalavanUnsal N, Bag-1L mediated chemoresistance mechanism through preventing
downregulation of Mcl-1 and c-Raf by heat shock proteins in HeLa cells, Asian
Pacific Journal of Cancer Prevention, 2014 (Accepted for publications, 2014)
3. Elif Damla Arisan, Yunus Akkoç*, Kaan Gencer Akyüz*, Ezgi Melek Kerman*,
Pinar Obakan, Ajda Çoker-Gürkan, Narçin Palavan Ünsal, “Polyamines modulate
roscovitine-induced cell death decision as autophagy or apoptosis in MCF-7 and
MDA-MB-231 breast cancer cells”, Molecular Medicine Reports, (Accepted for
publications, 2014).
4. Ajda Çoker-Gürkan, Elif Damla Arisan, Pinar Obakan, Pelin Özfiliz, Betsi Köse,
Güven Bıçkıcı, Narçin Palavan Ünsal, “Roscovitine finalized autophagy later than
apoptosis by downregulating of Bcl-2 in HeLa cells”, Molecular Medicine Reports,
(Accepted for publications, 2014).
5. A. Çoker-Gürkan, S. Arısan, E.D. Arısan, N. Palavan Ünsal, “Lack of evidence for
the association of ornithine decarboxylase (+316 G>A), spermidine/spermine acetyl
transferase (-1415 T>C) gene polymorphisms with calcium oxalate stone disease,
Biomedical Reports, 2013, DOI: 10.3892/br.2013.184 (Research Article).
6. P. Obakan, P. Ozfiliz, E.D. Arısan, A. Çoker-Gürkan, N. Palavan Ünsal, “Purvalanol
A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7
estrogen receptor positive breast cancer cells”, Molecular Biology Reports, 2013,
DOI: 10.1007/s11033-013-2847-1 (Research Article).
7. A.Çoker-Gurkan, E. D. Arisan, P. Obakan, N. Palavan-Ünsal, “Inhibition of
polyamine oxidase prevented cyclin dependent kinase inhibitor-induced apoptosis in
HCT116 colon carcinoma cells” Apoptosis, DOI: 10.1007/s10495-013-0885-8
(Research Article).
8. Çoker-Gurkan, S. Arisan, E. D. Arisan, N.C. Sönmez, N. Palavan-Ünsal,
“Association between IL-1RN VNTR, IL-1 –511 and IL-6 (–174, –572, –597) Gene
Polymorphisms and Urolithiasis” Urologia Internationalis, 2013 (Research Article).
9. A.Çoker, E.D. Arısan, Narcin Palavan-Unsal, "Silencing of polyamine catabolic key
enzyme SSAT prevented CDK inhibitors induced apoptosis in Caco-2 colon cancer
cells", Molecular Medicine Reports (ISI), 1037-1042 pp., 2012, DOI:
10.3892/mmr.2012.768 (Research Article).
10. E. D. Arısan, A.Coker, P.Obakan, N.Palavan-Unsal, "Inhibition of ornithine
decarboxylase altered the roscovitine-induced mitochondria mediated apoptosis in
MCF-7 breast cancer cells", Molecular Medicine Reports (ISI), 1323-1329 pp., 2012,
DOI: 10.3892/mmr.2012.786 (Research Article).
11. E.D.Arisan, A.Coker, N.Palavan-Unsal, "Polyamine depletion enhances the
roscovitine-induced apoptosis through the activation of mitochondria in HCT116
colon carcinoma cells", Amino Acids, 2011, DOI: 10.1007/s00726-011-1040-x
(Research Article).
Page 3 of 15
12. S.Akyuz, A.E.Ozel, K.Balci, T.Akyuz, A.Coker, E.D.Arisan, N.Palavan-Unsal,
A.Ozalpan, "Raman micro-spectroscopic analysis of cultured HCT116 colon cancer
cells in the presence of roscovitine", Spectrochimica Acta Part A: Molecular and
Biomolecular
Spectroscopy
A,
1540–1547
pp.,
2011,
DOI:
10.1016/j.saa.2011.01.046 (Research Article).
13. S.Akyuz, A.E.Ozel, K.Balci, T.Akyuz, A.Coker, E.D.Arisan, N.Palavan-Unsal,
A.Ozalpan, "Raman micro-spectroscopic investigation of the interaction of cultured
HCT116 colon cancer cells with alpha- difluoromethylornithine (DFMO), an
irreversible inhibitor of ornithine decarboxylase." Journal of Molecular Structure
319-323 pp., 2011, DOI: 10.1016/j.molstruc.2011.01.04 (Research Article).
14. A. Coker, A. Arman, O. Soylu, T. Tezel, A. Yildirim, “Lack of association between
IL-1 and IL-6 gene polymorphisms and myocardial infarction in Turkish
population”, International Journal of Immunogenetics, 38 (3), 201-208, 2011.
(Research Article).
15. A. Arman, A. Coker, O. Sarioz, N. Inanc, H. Direskeneli, “Lack of association
between IL-6 gene polymorphisms and rheumatoid arthritis in Turkish population”,
Rheumatol Int. Clinical and Experimental Investigation (DOI10.1007/s00296-0112057-x), 2011(Research Article).
16. A. Arman, N. Isik, A. Coker, F. Candan, K.S., Becit, E.O. List, “Association
between sporadic Parkinson disease and interleukin-1 beta -511 gene polymorphisms
in the Turkish population”,Eur Cytokine Netw., Jun;21(2):116-121,2010. (Research
Article).
17. A. Arman, B. Yüksel, A. Coker, O. Sarioz, F. Temiz, A.K. Topaloglu, “Novel
growth hormone receptor gene mutation in a patient with Laron syndrome”, J
Pediatr Endocrinol Metab. Apr;23(4):407-414, 2010. (Research Article).
18. A. Coker, E. Cetinkaya, B. Dundar, Z. Siklar, A. Buyukgebiz, A. Arman.
“Characterization of GH-1 mutations in children with isolated Growth Hormone
Deficiency in Turkish Population”, Journal of Pediatric Endocrinology &
Metabolism, Oct, 22 (10); 937-946, 2009. (Research Article).
19. A. Arman, A. Ozon, P.I. Isguven, A. Coker, I. Peker, N. Yordam, “Novel Splice Site
Mutation in the Growth Hormone Receptor Gene in Turkish patients with Laron-type
dwarfism”, Journal of Pediatric Endocrinology & Metabolism, Jan 21;47-58, 2008,
(Research Article).
20. O. Soylu, A. Yildirim, A. Coker, T. Tezel, E.O. List, A. Arman, “Interleukin-1B (511) gene polymorphism is associated with acute coronary syndrome in the Turkish
population”. Eur Cytokine Netw. Mar;19(1):42-48, 2008. (Research Article).
21. A. Arman, O. Soylu, A. Yildirim, A. Furman, N. Ercelen, H. Aydogan, A. Coker, T.
Tezel, “Interleukin-1 receptor antagonist gene VNTR polymorphism is associated
with coronary artery disease”.Arq Bras Cardiol. Nov;91(5):268-273, 2008 (Research
Article).
Page 4 of 15
22. A. Arman, B. Yılmaz, A. Coker, N. Inanc, H. Direskeneli, “Interleukin-1 Receptor
Antagonist (IL-1RN) and Interleukin-1B gene polymorphisms in Turkish patients
with Rheumatoid Arthritis”, Clin and Exp Rheumatol., Nov-Dec;24(6):643-648,
2006. (Research Article).
7.2 Papers delivered in international conferences and printed as proceedings
1- Ajda Çoker-Gürkan, Kübra Akalın, Utku Özbey, Elif Damla Arısan, Pınar Obakan,
Narçin Palavan-Ünsal, “Induction of Endoplasmic Reticulum (ER) stress-mediated
apoptosis and autophagy by Purvalanol in HCT 116 colon cancer cells” EACR Sponsored
2nd Anticancer Agents Congress& 5th Mutlidisciplinary Cancer Research Congress, PP13,
Sayfa: 99, 23-27 April 2014, Bodrum, TURKEY, (Selected Poster-Oral Presentation).
2- P. Obakan, E.D. Arisan, A. Coker-Gurkan, N. Palavan-Unsal, “ER stress is involved in
Epibrassinolide-induced apoptotic cell death” EACR Sponsored 2nd Anticancer Agents
Congress& 5th Mutlidisciplinary Cancer Research Congress, PP61, Sayfa: 147, 23-27
April 2014, Bodrum, TURKEY (Selected Poster-Oral Presentation).
3- Deniz Coskun, Pınar Obakan, Elif Damla Arisan, Ajda Çoker Gürkan, Narcin PalavanUnsal, “Epibrassinolide-induced Apoptosis is Modulated by AKT-FOXO3a Signaling
Pathway”, EACR Sponsored 2nd Anticancer Agents Congress& 5th Mutlidisciplinary
Cancer Research Congress, PP24, Sayfa: 110, 23-27 April 2014, Bodrum, TURKEY
(Selected Poster-Oral Presentation).
4- Özge Berrak, Elif Damla Arisan, Pinar Obakan, Ajda Çoker-Gürkan, Narcin PalavanUnsal, “The combination of rapamycin with purvalanol and roscovitine induces
autophagy through PI3K/AKT and Ras/Raf/Erk pathways regulation in DU 145 prostate
cancer cells” EACR Sponsored 2nd Anticancer Agents Congress& 5th Mutlidisciplinary
Cancer Research Congress, PP57, Sayfa: 143, 23-27 April 2014, Bodrum, TURKEY
(Selected Poster-Oral Presentation).
5- Pelin Özfiliz, Elif Damla Arısan, Pınar Obakan, Ajda Çoker-Gürkan, Gizem Dinler
Doğanay , Narçin Palavan Ünsal, “Silencing of Bag-1 enhanced the cisplatin or
paclitaxel-induced apoptosis via regulating PI3K, Akt and MAPK signaling axis in MCF7 breast cancer cells” EACR Sponsored 2nd Anticancer Agents Congress& 5th
Mutlidisciplinary Cancer Research Congress, PP59, Sayfa: 145, 23-27 April 2014,
Bodrum, TURKEY (Selected Poster-Oral Presentation).
6- H. Ilhan, A. Coker-Gurkan, E.D. Arisan, P. Obakan, N. Palavan Unsal. N.
Diethylnorspermine (DENSpm) Induced Apoptosis in SW480 Colon Cancer Cells, First
International Congress of the Molecular Biology Association of Turkey, 23-24 November
2012, Istanbul-TURKEY. (Poster Presentation: H. Ilhan)
7- Y. Akkoc, E.D. Arisan, A. Coker-Gurkan, P. Obakan, N. Palavan-Unsal. Understanding
the Role of Bcl-2 in Curcumin induced Autophagic/Apoptotic Cell Death Mechanism in
MCF-7 and MDA-MB-231 Breast Cancer Cells, First International Congress of the
Molecular Biology Association of Turkey, 23-24 November 2012, Istanbul-TURKEY.
(Poster Presentation: Y. Akkoc)
8- D. Coskun, P. Obakan, E.D. Arisan, A. Coker-Gurkan, N. Palavan-Unsal. Epibrassinolide
Induced Apoptotic Cell Death in HCT116 and HT29 Colon Carcinoma cells, First
Page 5 of 15
International Congress of the Molecular Biology Association of Turkey, 23-24 November
2012, Istanbul-TURKEY. (Poster Presentation: D. Coskun)
9- O. Berrak, Y. Akkoc, P. Obakan, E.D. Arisan, A. Coker-Gurkan, N. Palavan-Unsal.
Effects of CDK Inhibitors and Rapamycin Combination on Autophagy With The Status
of AR expression on Androgen Dependent LNCaP and Androgen Independent DU145
Prostate Cancer Cells, First International Congress of the Molecular Biology Association
of Turkey, 23-24 November 2012, Istanbul-TURKEY. (Poster Presentation: O.Berrak)
10- A. Çoker Gürkan A , P. Obakan, Arısan ED, Calcabrini A, Agostinelli E, Palavan-Ünsal
N, “The Effect of Polyamine Catabolism Products on CDK Inhibitors-Induced on
HCT116 wt and Bax-/- Colon Carcinoma Apoptotic Cell Death”, International Congress
on Polyamines Biological and Clinical Perspectives 2-7 September, Istanbul- TURKEY,
P15, p.126, 2012 (Oral Presentation: Ajda Çoker-Gürkan)
11- A. Çoker Gürkan, E.D. Arısan, N. Palavan-Ünsal, “Which is the most prominent cellular
decision against CDK inhibitors in the presence of modulated polyamine pool?
Autophagy or Apoptosis”, International Congress on Polyamines Biological and Clinical
Perspectives 2-7 September, Istanbul- TURKEY, P16, p.127, 2012 (Poster Presentation:
E Damla Arisan)
12- B. Köse, G. Alkurt, A. Çoker Gürkan, E.D. Arısan, P. Obakan, N. Palavan-Ünsal N,
“ODC is a Mediator of the Purvalanol-A-Induced Apoptotic Signaling via the p38
Mitogen-Activated Protein Kinase Pathway in MCF-7 Breast Cancer Cells”, International
Congress on Polyamines Biological and Clinical Perspectives, 2-7 September, IstanbulTURKEY, P18, p.130, 2012 (Poster Presentation: B. Köse ve G. Alkurt).
13- D. Coşkun, P. Obakan, E.D. Arısan, A. Çoker Gürkan, N. Palavan-Ünsal, “The Potential
Role of Polyamines in EBR-Induced Apoptotic Cell Death in HCT116 Colon Carcinoma
Cells”, International Congress on Polyamines Biological and Clinical Perspectives, 2-7
September, Istanbul- TURKEY, P20, p.134, 2012 (Poster Presentation: D. Coşkun).
14- H. İlhan H, A. Çoker Gürkan, P. Obakan, E.D. Arısan, N. Palavan-Ünsal, “Timing is
critical in the decision of apoptosis or autophagy by N1, N11-Diethylnorspermine
(DENSpm) treatment in HCT116 Colon Cancer Cells”, International Congress on
Polyamines Biological and Clinical Perspectives 2-7 September, Istanbul- TURKEY,
P24, p.142, 2012 (Poster Presentation: H. İlhan).
15- O. Irmak, E.D. Arısan, A. Çoker-Gürkan, P. Obakan, N. Palavan-Ünsal, “The Role of
Polyamine Catabolic Enzymes in Cisplatin-Induced Apoptotic Cell Death in MCF-7
Cells”, International Congress on Polyamines Biological and Clinical Perspectives, 2-7
September, Istanbul- TURKEY, P29, p.151, 2012 (Poster Presentation: O. Irmak).
16- Y. Akkoç, G.K. Akyüz, E.M. Kerman, E.D. Arısan, A. Çoker-Gürkan, P. Obakan, N.
Palavan-Ünsal,
“Potential
Role
of
Polyamines
in
Roscovitine-Induced
Autophagic/Apoptotic Cell Death in MCF-7 and MDA-MB-231 Breast Cancer Cells”,
International Congress on Polyamines Biological and Clinical Perspectives, 2-7
September, Istanbul- TURKEY, P41, p.170, 2012 (Poster Presentation: Y. Akkoç-GK
Akyüz-EM. Kerman).
17- Ş. Yıldırım, M.B. Özturk, E.D. Arısan, P. Obakan, A. Çoker- Gürkan, N. Palavan-Ünsal,
“PPAR is the Critical Upstream Factor in Cyclin-Dependent Kinase Inhibitors
Roscovitine and Purvalanol A- Induced SSAT Upregulation in MCF-7 Cells”,
Page 6 of 15
International Congress on Polyamines Biological and Clinical Perspectives, 2-7
September, Istanbul- TURKEY, P33, p.156, 2012 (Poster Presentation: Ş. Yıldırım-MB.
Öztürk).
18- Z. Akyol, A. Çoker-Gürkan, E.D. Arısan, N. Palavan-Ünsal, “N1, N11Diethylnorspermine (DENSpm) Modulates the Paclitaxel-Induced Apoptosis in MCF-7
wt and Bcl-2 Overexpressing Breast Cancer Cells”, International Congress on
Polyamines Biological and Clinical Perspectives, 2-7 September, Istanbul- TURKEY,
P39, p.168, 2012 (Poster Presentation: Z. Akyol).
19- Y. Akkoç, M. Çelik, P. Obakan, A. Çoker Gürkan, E.D. Arisan, N. Palavan-Ünsal, “The
functional role of Bcl-2 in the regulation of curcumin induced autophagic/apoptotic cell
death in MCF-7 breast cancer cells”, Conference on Apoptosis and Cancer, Cambridge,
UK, June 14-15 2012, (Poster Presentation: Y. Akkoç-M. Çelik).
20- A.Coker, E.D.Arisan, N.Palavan-Unsal. Roscovitine modulated autophagic cell death
related to polyamine metabolism in HCT-116 colon cancer cells. International Congress
on Biogenic Amines: Biochemical, Physiological and Clinical Perspectives. 48 pp. 21–
25 Eylül, Alberè di Tenna (Trento), Italy, 2011 (Selected Poster-Oral Presentation: A.
Coker)
21- A.Coker, S.Arisan, D.Coskun, A.Yavuz, E.D.Arisan, N.C.Sonmez, N.Palavan-Unsal.
Investigation of Fetuin-A SNP in urinary stone disease patients 4th International
Congress of Molecular Medicine, 67pp., 27-30 June, Istanbul- TURKEY, 2011 (Poster
Presentation: D. Coskun)
22- A. Coker, S.Arisan, D. Coskun, A.Yavuz, E. D. Arisan, N.C. Sonmez, N. Palavan-Unsal.
“Investigation of Fetuin-A SNP in urinary stone disease patients”, in vivo International
Journal of Experimental and Clinical Pathophysiology and Drug Research, May- June
2011, 25 (3), Page: 521.
23- A. Coker, S. Arisan, D. Coskun, T. Kizilboga, ED. Arisan, NC. Sönmez, S. Guney, N.
Palavan-Ünsal “The Investigatin of possible association between Fetuin-A 766 CC and
IL-10 (-1082 AG and -572 AC) gene polymorphism in urolithiasis” 1st Meeting of the
EAU Section of Urolithiasis (EULİPS), E91, 7-10 Eylül 2011, London, England,
European Urology Supplements 10 (2011), Page: 484.
24- A. Coker, T. Kizilboga, E.D. Arisan, S. Arisan, N.C. Sönmez, S. Guney, N. PalavanÜnsal “Interleukin-1 beta (-511 CT), receptor antagonist VNTR and Interleukin-6 (-174
G C, -592GA) gene polymorphisms in urolithiasis”, 1st Meeting of the EAU Section of
Urolithiasis (EULİPS), E92, 7-10 September 2011, London, England, European Urology
Supplements 10 (2011), Page: 484-485, 2011.
25- A.Coker, E.D.Arisan, N.Palavan-Unsal. Modulation of catabolic pathway in ROSC
treated Caco-2 cells. "2nd International Conference on the Role of Polyamines and their
Analogs in Cancer and other Diseases” 199 pp., 1-6 December, Sapienza University of
Rome, Italy, 2010 (Oral Presentation: A. Coker)
26- N.Palavan-Unsal, E.D.Arisan, P.Obakan, A.Coker, I.Ozdemir. Cyclin dependent kinase
inhibitors modulates polyamine metabolism in MDA-MB-231 cells. "2nd International
Conference on the Role of Polyamines and their Analogs in Cancer and other Diseases”
1-6 December, Sapienza University of Rome, Italy, 131 pp., 2010 (Oral Presentation: N.
Palavan Ünsal)
Page 7 of 15
27- E.D.Arisan, P.Obakan, A.Coker, N.Palavan-Unsal. Investigation of purvalanol-induced
apoptosis in MCF-7 breast cancer cell lines. "2nd International Conference on the Role of
Polyamines and their Analogs in Cancer and other Diseases” 193 pp., 1-6 December,
Sapienza University of Rome, Italy, 2010 (Poster Presentation: E. D. Arisan)
28- P.Obakan, E.D.Arisan, N.Palavan-Unsal, A.Coker. Combined treatment of Roscovitine
and DFMO induced caspase dependent-apoptosis in MCF-7 cells. "2nd International
Conference on the Role of Polyamines and their Analogs in Cancer and other Diseases”
1-6 December, Sapienza University of Rome, Italy, 205 pp., 2010 (Oral Presentation:
P.Obakan)
29- S.Akyuz, A.E.Ozel, K.Balci, T.Akyuz, A.Coker, E.D.Arisan, N.Palavan-Unsal,
A.Ozalpan. Micro Raman spectroscopic investigation of the interaction of cultured
HCT116 colon cancer cells with alpha-difluoromethylornithine (DFMO), an irreversible
inhibitor of ornithine decarboxylase. EUCMOS 30th European congress on molecular
spectroscopy with GISR, Florence, Italy, PS2-21, 107 pp., 2010 (Oral Presentation: S.
Akyuz)
30- A.Coker, E.D.Arisan, N.Palavan-Unsal. The involvement of polyamines in seliciclib
induced apoptosis and ROS generation in HCT116 colon carcinoma cells. Joint 4th
EORTC Pathobiology Group Annual Meeting and 1st Internationally Multidisciplinary
Cancer Research Congress. P13, Antalya-Turkey, 2009 (Poster Presentation: A. Coker)
31- S.Akyuz, A.E.Ozel, K.Balci, T.Akyuz, A.Coker, E.D.Arisan, N.Palavan-Unsal,
A.Ozalpan. Micro raman spectroscopic investigation of the interaction of cultured
HCT116 colon cancer cells with roscovitine. 5th International Conference on Vibrational
Spectroscopy (ICAVS5), 31 pp., Melbourne, Australia, 12-17 July, 2009 (Oral
Presentation: S. Akyuz)
32- A. Coker, A. Arman, O. Sarıoz, B. Yüksel, A. Ozon “Growth hormone receptor (GHR)
mutations in Turkish Children with Laron Syndrome”, 11th European Congress of
Endocrinology, 25-29 April 2009, Endocrine Abstracts (2009) V: 20, P527, IstanbulTURKEY (Poster Presentation: A. Coker).
33- A. Arman, A. Coker, E. Cetinkaya, B. Dundar, Z. Siklar, O. Sarioz, A. Buyukgebiz,
“Genetic characterization of children with isolated Growth Hormone Deficiency in
Turkish Population”, 11th European Congress of Endocrinology, 25-29 April 2009,
Endocrine Abstracts (2009) V: 20, P526, Istanbul- TURKEY (Poster Presentation: A.
Arman).
34- A. Arman, E. Cetinkaya, B. Dundar, Z. Sıklar, A. Coker, A. Buyukgebiz,
“Characterization GH-N mutations in children with isolated Growth Hormone Deficiency
in Turkish Population”, 47th Annual Meeting of the European Society for Paediatric
Endocrinology (ESPE), P2-d3-662, 20-23 September 2008, İstanbul-Turkiye, Hormone
Research From Developmental Endocrinolgy to Clinical Research, 70: Suppl. 1, Sayfa:
197 (Poster Presentation: A. Arman).
35- A. Arman, A. Coker, O. Soylu, A. Yildirim, T. Tezel, “A genetic association between
Myocardial Infarction (MI) and Interleukin-1 B (+ 3953) gene polymorphism in turkish
population”, 15th Meeting of Balkan Clinical Laboratory Federation, 4-7 September
2007, Antalya- TURKEY, Balkan Journal of Clinical Laboratory, XIV, 07, 1, OP-11
(Oral Presentation: A. Arman).
Page 8 of 15
36- S. Turan, A. Arman, T. Guran, T. Akcay, A. Coker, A. Bereket, “Novel Mutations in
cathepsin K gene in Turkish patients with pycnodysostosis”, 46th Annual Meeting of the
European Society for Paediatric Endocrinology (ESPE), P01-225, 27-30 June 2007,
Helsinki-Finlandiya, Hormone Research From Developmental Endocrinology to Clinical
Research, 68: Suppl.1, Sayfa: 70, (Poster Presentation: S. Turan).
37- P. Isguven, A. Arman, M. Yildiz, I. Arslanoglu, A. Coker, M. Erguven, “Novel Splice
site mutation of the growth hormone receptor gene in Turkish boy with Laron syndrome”,
46th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE), P03558, 27-30 June 2007, Helsinki-Finlandiya, Hormone Research From Developmental
Endocrinology to Clinical Research, 68: Suppl. 1, Sayfa: 173 (Poster Presentation: P.
Isgüven).
38- A. Coker, A. Arman, “No association between IL-1 A -889 polymorphism and Coronary
Artery Disease (CAD) in Turkish Population”, II. Congress of Molecular Medicine From
Cell the Bedside, 24-26 March 2007, P045, Sayfa: 282, Istanbul- TURKEY, (Poster
Presentation: A. Coker).
39- A. Arman, A. Coker, “The prevalence of Interleukin-1 Receptor Antagonist gene (IL1RN) VNTR polymorphism in Turkish Population”, II. Congress of Molecular Medicine
From Cell the Bedside, 24-26 March 2007, P046, Sayfa: 282-283, Istanbul- TURKEY,
(Poster Presentation: A. Arman).
40- S. Becit, A. Arman, A. Coker, N. Isık, F. Candan, “The lack association between
Interleukin 1 A -889 polymorhism and Parkinson Disease in Turkish Population”, II.
Congress of Molecular Medicine From Cell the Bedside, 24-26 March 2007, P047,
Sayfa:283, Istanbul- TURKEY, (Poster Presentation: S. Becit).
41- A. Coker, A. Arman, O. Soylu, A. Yıldırım, N. Ercelen, H. Aydogan, T. Tezel,
“Interleukin-1 Receptor Antagonist 2/2 Genotype is associated with Single Vessel
Coronary Artery Disease in Turkish Population, FEBS Forum for Young Scientists, 2006,
Istanbul- TURKEY (Oral Presentation: A. Çoker).
42- A. Coker, A. Arman, O. Soylu, A. Yıldırım, N. Ercelen, H. Aydogan, T. Tezel,
“Interleukin-1 Receptor Antagonist 2/2 Genotype is associated with Single Vessel
Coronary Artery Disease in Turkish Population”, 31st FEBS Congress, 24-29 June 2006,
PP-498, the FEBS Journal, V:273, Supplement:1, Sayfa:211, Istanbul- TURKEY (Poster
Presentation: A. Çoker).
43- A. Arman, A. Ozon, P.S. Isguven, N. Yordam, A. Coker, I. Peker, “Mutations of the
Growth Hormone Receptor Gene in Turkish patients with Laron-type dwarfism”, 31st
FEBS Congress, 24-29 June 2006, OP-10, the FEBS Journal, V:273, Supplement:1,
Sayfa:45, Istanbul- TURKEY(Poster Presentation: A. Arman).
44- A. Arman, A. Coker, “Growth Hormone Antagonist, G120K treated-Cell Line
Expressing W122A mutation of GHR did not reverse STAT5 phosphorylation”, 1st
Congress of Molecular Medicine From Cell to Bedside, 16-19 April 2005, Advances in
Molecular Medicine International Journal of Molecular Biology, Biochemistry and Gene
Technology, V (1), Supplement, P153, Sayfa:455-456, 2005, Istanbul- TURKEY, (Poster
Presentation: A. Arman).
45- A. Arman, A. Coker, “Applications of Ribozymes in Medicine”, 1st Congress of
Molecular Medicine From Cell to Bedside, 16-19 April 2005, Advances in Molecular
Page 9 of 15
Medicine International Journal of Molecular Biology, Biochemistry and Gene
Technology, V(1), 5 Supplement, P156, Sayfa:456-457, 2005, Istanbul- TURKEY,
(Poster Presentation: A. Arman).
46- A. Arman, A. Coker, “JAK2 is not involved in the regulation the activation of Stat3induced by IL-1”, 11th International Biomedical Science and Technology Days, 6-10
September 2004, GBP10, Sayfa: 66, Ankara- TURKEY, (Poster Presentation: A. Çoker).
47- A. Arman, A. Coker, “The Effect of Sodium Arsenite and 15-deoxy12, 14-PGJ2 on IL1 induced hSIE, StatBE, NF-B and APRE Reporter Plasmids”, 11th International
Biomedical Science and Technology Days, 6-10 September 2004, GBP08, Sayfa: 65,
Ankara- TURKEY, (Poster Presentation: A. Çoker).
7.3 Books and sections in books published internationally
7.4 Articles published in peer reviewed national journals
1- Ajda COKER, Ahmet ARMAN Human Growth Hormone Normal (hGH-N)
Advances in Molecular Biology, Volume: 3, Number 1-2, 9-16, 2010.
7.5 Papers delivered at national conferences and printed as proceedings
1. N. Erzaim, A. Arman, Ş. Aktan, A. Çoker, N. Işık, “NFkB (-94 ins/del ATTG) Gen
Polimorfizminin Türk Populasyonda Multipl Skleroz İle İlişkisi”, XII. Ulusal Tıbbi
Biyoloji ve Genetik Kongresi, 27-30 October 2011, Antalya-TURKEY, Türkiye
Klinikleri Tıp Bilimleri Dergisi, 2011; 31 (Suppl), Page:219 (Poster Presentation: N.
Erzaim).
2. Ş. Aktan, A. Arman, N. Erzaim, A. Çoker, N. Işık, “Türk toplumunda IL-8 -251 A/T
Gen Polimorfizminin Multipl Skleroz (MS) Hastalığı ile İlişkisi”, XII. Ulusal Tıbbi
Biyoloji ve Genetik Kongresi, 27-30 October 2011, Antalya-TURKEY, Türkiye
Klinikleri Tıp Bilimleri Dergisi, 2011; 31 (Suppl), Page: 219 (Poster Presentation:
Ş.Aktan).
3. A. Coker, A. Arman, B. Yüksel, F. Temiz, A.K Topaloglu, “Laron Sendromlu
Hastalarda Büyüme Hormonu Reseptörü Geninde Mutasyon Taranması ve W104R
Mutasyonunun Biyolojik Aktivitesinin Belirlenmesi” XIII. Ulusal Pediatrik Endokrin
ve Diyabet Kongresi, 17-21 November 2009, Antalya-TURKEY, SS-04, Page: 96
(Oral Presentation: A. Çoker).
4. A. Arman, A. Coker, E. Cetinkaya, B. Dundar, Z. Siklar, A. Buyukgebiz, “İzole
Büyüme Hormonu Eksikliği Sendromlu Çocukların Büyüme Hormonu Geninde tespit
ettiğimiz mutasyonların fonksiyonlarının hücre kültüründe belirleme” XIII. Ulusal
Pediatrik Endokrin ve Diyabet Kongresi, 17-21 November 2009, SS-03, AntalyaTURKEY, Page: 95 (Oral Presentation: A.Arman).
5. A. Coker, A. Arman O. Soylu, A. Yıldırım, T. Tezel, “Türk Populasyonunda
İnterlökin-1 B (-511) gen polymorfizminin akut koroner sendrom ile ilişkilisi” X.
Page 10 of 15
6.
7.
8.
9.
Ulusal Tıbbi Biyoloji ve Genetik Kongresi, 6-9 September 2007, Antalya- TURKEY,
S34, Page: 112 (Oral Presentation: A. Çoker).
Ö. Sarıöz, A. Arman, A. Çoker, N. İnanc, H. Direskeneli, “Türk Populasyonunda,
Romatoid Artritli Hastalarda, İnterlökin-6 Gen Polimorfizmlerinin İncelenmesi”, IX
Ulusal Romatoloji Kongresi, 11-15 October 2008, Antalya-TURKEY, P0041, Page:
156 (Poster Presentation: O. Sarıöz).
S. Becit, A. Arman, A. Coker, N. Isık, F. Candan, “Türk Parkinson Hastaları’nda
İnterlökin-1 Reseptör Antagonist (IL-1RN) ve İnterlökin-1B Gen Polimorfizmleri” X.
Ulusal Tıbbi Biyoloji ve Genetik Kongresi, 6-9 September 2007, Antalya-TURKEY,
P36, Page: 156 (Poster Presentation: S. Becit).
O. Sarioz, A. Arman, A. Coker, S. Becit, H. Direskeneli, “Lack of association
between Interleukin-1 Alpha (-889) gene polymorphisms and Rheumatoid Arthritis in
Turkish population”, X. Ulusal Tıbbi Biyoloji ve Genetik Kongresi, 6-9 September
2007, Antalya- TURKEY, P92, Page: 212 (Poster Presentation: O. Sarıöz).
A. Arman, B. Yılmaz, A. Çoker, N. İnanc, H. Direskeneli, “Türk Populasyonunda,
Romatoid Artritli Hastalarda, İnterlökin-1 Reseptör Antagonist (IL-1RN) ve
İnterlökin-1B Gen Polimorfizmlerinin incelenmesi”, Romatoloji 2005, 30 August-4
September 2005, Konya-TURKEY, SS-6, Page: 151 (Poster Presentation: A. Arman).
7.6 Other publications
1.
2.
3.
4.
5.
A. Coker-Gurkan, E. D. Arisan, H. İlhan, P. Obakan, N. Palavan-Unsal, “Inhibition
of Cellular Autophagic Responses against N1, N11-Diethylnorspermine (DENSpm)
Enhanced Apoptosis in HCT116 and SW480 Colon Cancer Cells”, 16-21 June 2013,
Waterville Valley, USA (Poster Presentation: Ajda Çoker Gürkan)
E. D. Arısan, M.B Öztürk, A. Çoker-Gürkan, P. Obakan, N. Palavan-Ünsal,
“Ibuprofen induced apoptosis through c-myc sifgnaling pathway related to
polyamines in p53 null PC3 cells”, 16-21 June 2013, Waterville Valley, USA (Poster
Presentation: Damla Arısan)
D. Coskun, P. Obakan, E.D. Arisan, A. Coker-Gurkan, N. Palavan-Unsal, “The
Potential Role of Polyamines in Epibrassinolide-Induced Apoptotic Cell Death in
HCT116 and HT29 Colon Carcinoma Cells”, 16-21 June 2013, Waterville Valley,
USA (Poster Presentation: Narçın Palavan Ünsal).
O. Berrak, E.D. Arisan, P. Obakan, A. Coker- Gurkan, N. Palavan-Unsal, “Cotreatment of rapamycin prevented activation of polyamine oxidase and apoptosis via
triggering autophagy after CDK inhibitor treatment in LNCaP cells”, 16-21 June
2013, Waterville Valley, USA (Poster Presentation: Özge Berrak)
Y. Akkoç, E.D. Arisan, P. Obakan, A. Çoker-Gürkan, N. Palavan-Ünsal, “Cotreatment of PI3K inhibitor and curcumin overcomes Bcl-2 mediated drug-resistance
in MCF-7 breast cancer cells via activating SSAT”, 16-21 June 2013, Waterville
Valley, USA (Poster Presentation: Yunus Akkoç)
Page 11 of 15
P. Obakan, P. Özfiliz, E.D. Arisan, A. COKER-GURKAN, N. PALAVAN-UNSAL,
“Purvalanol A is a Strong Apoptotic Inducer via Activating Polyamine Catabolic
Pathway in MCF-7 Estrogen Receptor + Breast Cancer Cells”, EMBO Young
Scientist Forum, 14-16 June 2012, Istanbul-TURKEY (Poster Presentation: P.
Obakan).
7. N. Palavan-Unsal, E.D. Arisan, A. Coker, “Alterations in Apoptotic and Polyamine
Catabolic Pathway in HCT116wt and HCT116 Puma-/- Cell Lines Treated with Cdk
Inhibitors Gordon Research Conferences on Polyamines”, Polyamine Genetics,
Metabolism, Cellular Homeostasis and Drug Discovery, 19-24 June 2011, Waterville
Valley, USA (Poster Presentation: N. Palavan-Unsal)
8. A. Coker, N. Palavan-Unsal, E.D. Arisan, “Alterations in Apoptotic and Polyamine
Catabolic Pathway in HCT116 wt and HCT116 Bax-/- Cell Lines Treated with Cdk
Inhibitors”, Gordon Research Conferences on Polyamines, Polyamine Genetics,
Metabolism, Cellular Homeostasis and Drug Discovery, 19-24 June 2011, Waterville
Valley, USA (Poster Presentation: A. Coker).
9. N. Palavan-Unsal, E.D. Arisan, A. Coker, “Roscovitine induced apoptosis is
enhanced by ODC inhibition in HCT116 colon carcinoma cells”, Gordon Research
Conferences on Polyamines. Polyamine Genetics, Metabolism, Cellular Homeostasis
and Drug Discovery, 21-26 June 2009, Waterville Valley, USA (Poster presentation:
N. Palavan-Ünsal)
10. E.D.Arisan, N.Palavan-Unsal, A.Coker. ODC siRNA sensitizes HCT116 colon
carcinoma cells to roscovitine induced apoptosis. Gordon Research Conferences on
Polyamines. Polyamine Genetics, Metabolism, Cellular Homeostasis and Drug
Discovery. 21-26 June 2009 Waterville Valley, USA (Poster presentation: E. D.
Arisan)
6.
8.
Projects directed and participated
1. Curcumin’in terapotik etkinliğinin otokrin büyüme hormonu sinyal yolağı
aracılığı ile farklı meme kanseri hücrelerinde poliamin metabolizması irdelenerek
incelenmesi” (1001-TÜBİTAK KBAG- Project No: 113Z791, 2014-2017,
Director)
2. Epibrassinolidle Tetiklenen Hücre Ölümünün Endoplazmik Retikulum Stresi İle
İlişkisinin Kolon Kanseri Hücre Hatlarında Araştırılması (3001-TÜBİTAK
Başlangıç 3001, 113Z845, 2014-2016, Researcher)
3. N1, N11- Dietilnorspermin (Denspm)' in Hct116 Ve Sw480 Kolon Kanseri
Hücrelerinde Otofaji Uzerine Etkisinin Poliamin Metabolizması Açısından
Araştırılması, TÜBİTAK (TBAG 212T227- 15/02/2013-15/02/2014, Director).
4. Bax veya Puma ifadesi görülmeyen HCT116 kolon kanseri hücrelerinde
epibrassinolidin terapötik etkisinin modellenmesi (Project Director: Prof. Dr.
Narçin Palavan Ünsal, Master Thesis of Onur Irmak).
Page 12 of 15
5. Diklofenak’ın apoptotik etkilerinin NFkB ve PPAR ile etkileşimi sonucunda
DLD-1 ve SW480 kolon kanseri hücrelerinde gösterimi (Project director: N.
Palavan Ünsal, Research Project of Şeyma Yıldırım)
6. Epibrassinolidin terapotik etkisinin kolon kanseri hücre hatlarında gösterimi
(Project director: N Palavan Ünsal, Master Thesis of Deniz Coşkun and Esin
Güvenir, TUBİTAK 1002, January 2013-January 2014)
9. Administrative designations






2013- Istanbul Kultur University, Molecular Biology and Genetics Department,
Department WEB-Coordinator.
2012- Istanbul Kultur University, Molecular Biology and Genetics Department,
Department Accreditation Community Member.
2012- Istanbul Kultur University, Molecular Biology and Genetics Department,
Foreign Student Advisor.
2011- Istanbul Kultur University, Molecular Biology and Genetics Department,
Department Bologna Coordinator
2009- Istanbul Kultur University, Molecular Biology and Genetics Department,
Department ECTS Coordinator.
2009-2010- Istanbul Kultur University, Molecular Biology and Genetics
Department, Secretary of Advances in Molecular Biology Journal
10. Membership in scholarly institutions
2008 Moleküler Kanser Araştırma Derneği (MOKAD) Üyeliği
2009 European Association for Cancer Research (EACR) Üyeliği
2012 Moleküler Biyoloji Derneği
11. Awards and grants








2012- Istanbul Kultur University, Academic Achievement Award
2011- Biogenic Amines Congress, Selected Poster Presentation
2011- Biogenic Amines Congress, Participation and Views Scholarship.
2011- La Sapienza University, Academic Personal Exchange, ERASMUS,
Scientific Research, September 2011.
2010- Istanbul Kultur University, Academic Achievement Award
2009- Istanbul Kultur University, Academic Achievement Award
2009- XIII. Ulusal Pediatrik Endokrin ve Diyabet Kongresi, Mansiyon Award
2009- XIII. Ulusal Pediatrik Endokrin ve Diyabet Kongresi, Participation and
Views Scholarship
Page 13 of 15



2009- Joint 4th Eortic Pathobiology Group Annual Meeting and 1st International
Multidisciplinary Cancer Research Congress, Participation and Views Scholarship
2009- Istanbul Kultur University, Academic Achievement Award
2006- FEBS Forum for Young Scientists, Participation and Views Scholarship
12. Courses taught over the last two academic years:
Academic
Year
Term
Hours/week
Theoretical Applied
Biology
2
8
Course Name
Molecular
32
Techniques I
Introduction
Fall
2012-2013
to
2
0
33
Immunology
Industrial Microbiology
2
0
27
Developmental Biology
2
0
Senior Projects I
Research Project I
Molecular Biology
Techniques II
Preimplantation
3
0
2
0
4
8
21
5
1
2
0
Page 14 of 15
33
29
Genetic Diagnosis
Spring
Number of
Students
Genetic Engineering
2
0
25
Human Genetics
2
0
28
Tumor Immunology*
4
0
Senior Projects I
Research Project I
3
0
0
4
1
5
1
Academic
Year
Term
Hours/week
Theoretical Applied
Biology
2
8
Course Name
Molecular
31
Techniques I
Introduction
to
2
0
25
Immunology
Fall
Industrial Microbiology
2
0
26
Developmental Biology
2
0
Senior Projects I
Research Project I
Tumor Immunology*
3
0
4
0
4
0
22
7
2
Thesis*
Molecular Biology
Techniques II
Preimplantation
2013-2014
2
8
2
0
29
22
Genetic Engineering
2
0
29
Human Genetics
2
0
32
4
0
Genomics
and
2
Proteomics
Senior Projects I
Research Project I
Thesis*
Page 15 of 15
1
1
Genetic Diagnosis
Spring
Number of
Students
3
0
0
4
8
2
1

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