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Antioxidant Activity of Bisbenzylisoquinoline Alkaloids from

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Journal Of Enzyme Inhibition And Medicinal Chemistry
Antioxidant Activity of Bisbenzylisoquinoline Alkaloids from
Stephania rotunda: Cepharanthine and fangchinoline
Journal: Journal Of Enzyme Inhibition And Medicinal Chemistry
Manuscript ID: GENZ-2009-0029
Manuscript Type: Normal Article
Keywords:
Antioxidant activity, Cepharanthine, Fangchinoline, Stephania
rotunda, Alkaloid
URL: http:/mc.manuscriptcentral.com/genz Email: [email protected]
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Journal Of Enzyme Inhibition And Medicinal Chemistry
Antioxidant Activity of Bisbenzylisoquinoline Alkaloids from
Stephania rotunda: Cepharanthine and fangchinoline
1,
2
3
2
1
İlhami Gülçin ∗ , Riad Elias , Akçahan Gepdiremen , Aun Chea , Fevzi Topal
For
1
Peer
Atatürk University, Faculty of Sciences, Department of Chemistry
TR-25240-Erzurum-TURKEY
2
Laboratory of Pharmacognosy and Homeopathy, Pharmacy Faculty of Mediterranean University,
13385-Marseille Cedex 5-FRANCE
3Abant
Đzzet Baysal University,
Review
MedicalFaculty,Departmentof
Pharmacology, 14280-Gölköy-Bolu-TURKEY
∗ Corresponding
Author:
Atatürk University
Faculty of Sciences
Department of Chemistry
TR-25240-Erzurum-TURKEY
Tel
: +90 442 2314444
Fax
: +90 442 2360948
E-mails: [email protected] :
[email protected]
Only
URL: http:/mc.manuscriptcentral.com/genz Email: [email protected]
Journal Of Enzyme Inhibition And Medicinal Chemistry
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ABSTRACT
In the present study, we determined the antioxidant activity of cepharanthine and fangchinoline from
Stephania rotunda by performing different in vitro antioxidant assays including 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH·) scavenging, 2,2´-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)
(ABTS) radical scavenging activity, N,N-dimethyl-p-phenyl-enediamine dihydrochloride (DMPD)
radical scavenging, superoxide anion (O2·-) radical scavenging, hydrogen peroxide scavenging, total
antioxidant activity, reducing power and ferrous ions (Fe2+) chelating activities. Cepharanthine and
fangchinoline showed 94.6 and 93.3% inhibition on lipid peroxidation of linoleic acid emulsion at 30
µg/mL concentration, respectively. On the other hand, butylated hydroxyanisole (BHA), butylated
hydroxytoluene (BHT), α-tocopherol and trolox indicated inhibition of 83.3, 92.2, 72.4 and 81.3% on
peroxidation of linoleicPeeracidemulsionatthesame concentration (30 Ig/mL), respectively. According to
the results, cepharanthine and fangchinoline had effective antioxidant and radical scavenging
activity.
Keywords: Antioxidant activity; Cepharanthine; Fangchinoline; Stephania rotunda; Alkaloid; Radical
scavenging
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