International Congress on Head and Neck Tumors

International Congress
on Head and Neck Tumors
1st Congress of Croatian Head and Neck Society
20 - 22 October 2011
Zagreb, Croatia
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Message from the organizer
Dear friends and colleagues,
it is my great honour and pleasure to invite you to participate in the International Congress on Head and Neck Tumors organized by Croatian Head and Neck
Society that will be held in Zagreb, Croatia on October 20-22, 2011.
The Croatian Head and Neck Society founded in March 2010 has been established to actively participate in increasing public awareness of Head and Neck Tumors as well as to highlight the importance of both early diagnosis and treatment
of these tumors.
The major purpose of this Congress is to exchange scientific knowledge and
progress made in the field of research and education in Head and Neck oncology.
It is also our intent to point out the necessity of multidisciplinary team approach to the management of patients suffering from Head and Neck Tumors.
Covering main scientific topics such as New Horizons in Chemoradiotherapy for
Head and Neck Tumors, Oral Cavity Cancer, Thyroid Cancer and Laryngeal Cancer
this Congress will certainly be of your interest and provide you with the opportunity to learn from the experiences of the world experts in all of these fields.
I wish you a very pleasant and fruitful stay in Zagreb.
Looking forward to welcoming you all in Zagreb,
Kindest regards,
Drago Prgomet, MD, PhD
Congress President
Scientific Committee
Jasminka ALAGIĆ SMAILBEGOVIĆ, Bosnia and Herzegovina
Naranđa ALJINOVIĆ RATKOVIĆ, Croatia
Karine AUBRY, France
Vladimir BEDEKOVIĆ, Croatia
Woong Youn CHUNG, South Korea
Peter G. CORDEIRO, USA
Bogdan ČIZMAREVIČ, Slovenia
Andreas DIETZ, Germany
Damir DODIG, Croatia
Danijel DOŠEN, Croatia
Davorin ĐANIĆ, Croatia
Hans ECKEL, Austria
Dan FLISS, Israel
Wojciech GOLUSINSKI, Poland
Mirko IVKIĆ, Croatia
Rajko JOVIĆ, Serbia
Mario JURIĆ, Bosnia and Herzegovina
Sang Wook KANG, South Korea
Jan KLOZAR, Czech Republic
Zvonko KUSIĆ, Croatia
Dinko LEOVIĆ, Croatia
Sonja LEVANAT, Croatia
Adem LIMANI, Kosovo
Ivica LUKŠIĆ, Croatia
Spomenka MANOJLOVIĆ, Croatia
Anton MIKIĆ, Serbia
Nikola NIKOLOVSKI, Macedonia
Jan OLOFFSON, Norway
Krešimir PAVELIĆ, Croatia
Valdi PEŠUTIĆ, Croatia
Cesare PIAZZA, Italy
Zoran RAKUŠIĆ, Croatia
Marc REMACLE, Belgium
Sven SEIWERTH, Croatia
Jatin P. SHAH, USA
Ricard SIMO, UK
Radan STARČEVIĆ, Croatia
Vedran UGLEŠIĆ, Croatia
Mišo VIRAG, Croatia
Croatian Head and Neck Society Committe
President
Drago PRGOMET
Vice Presidents
Mirko IVKIĆ
Zoran RAKUŠIĆ
Secretary
Ivica LUKŠIĆ
Organizing Comittee
Mario BILIĆ
Vesna BIŠOF
Zaviša ČOLOVIĆ
Zdenka HUTINEC
Renato JANUŠIĆ
Saša JANJANIN
Željko KOTROMANOVIĆ
Lana KOVAČ BILIĆ
Robert TIĆAC
Davor VAGIĆ
Program
Thursday, October 20, 2011
08.30 – 09.15 Opening ceremony
Olofsson J
European specialization in head and neck oncology
09.15– 10.00 Welcome cocktail
10.00 – 11.30 Head and Neck Cancer – General Session I
Moderator: Golusinski W, Grce M
Pavelić K
High-throughput personalized medicine to bring forward
head and neck oncology
Klozar J
Clinical implications of HPV in head and neck tumors
Zvrko E, Mikić A, Jančić S
Relationship of E-cadherin with cervical lymph node
metastasis in laryngeal cancer
Fočo F, Bilalović N, Vranić S, Serdarević F, Ramović I, Imamović E
Is there a correlation between peritumoral expression of protein p53 in oral carcinoma and its relapse?
Rogan SA, Balenović A, Anić P, Ivkić M, Lukšić I
Usefulness and limitations of FDG/PET in the detection of malignancy in treated head and neck squamos cell carcinoma
12.00 – 13.30 Head and Neck Cancer – General Session II
Moderator: Klozar J, Ivkić M
Golusinski W
Young adults in head and neck cancer
Program
Milisavljević D, Stanković M, Živić M, Petrović D, Stanković P
Head and neck cancer surgery in elderly
Limani A
Locoregionally advanced head and neck cancer, possibilities
and challenges
Petrović D, Stanković M, Vučković I, Pešić Z, Milisavljević D, Petrović S, Djokić I, Stanković P
The influence of different treatment modalities on the functional outcome and survival rate for oral and oropharyngeal carcinoma
Alajbeg I, Pastorčić Grgić M, Gršić K, Andabak-Rogulj A, Stubljar B, Tomičević T
Strategies for prevention and treatment of head and neck radiotherapy complications - our experiences
Beketić-Orešković L
Use of enteral nutrition in patient with head and neck malignancies
13.30 – 14.30
Lunch
Sponsored by Medtronic
14.30 – 16.00 Laryngeal Cancer
Moderator: Simo R, Starčević R
Olofsson J
Laryngeal cancer. Diagnosis and therapy in past, present and future
Piazza C
Hypopharyngeal reconstruction by fascio-cutaneous free flaps
Jović MR, Čanji K, Dragičević D, Gašić J
Near total laryngectomy in management of selected patients with advanced laryngeal and pharyngolaryngeal carcinomas
Program
Stanković M, Milisavljević D, Stojanov D, Živić M, Živaljević S, Stanković I
Influential factors, complications, and survival rate of primary and salvage total laryngectomy for advanced laryngeal cancer
Znaor T, Večerina-Volić S, Trotić R, Ivanković D,
Papeš V, Lajtman Z
The role of mucosal wave in the early detection of glottic cancer
Đanić Hadžibegović A, Đanić D, Tičac R, Kozmar A
Analysis of pepsin in patients with tracheoesophageal fistula
and voice prosthesis complications
Mikić A, Zvrko E, Trivić A, Stefanović D, Golubović M
Small Cell Neuroendocrine Tumor of the Larynx – A Small Case Series
16.00 – 16.30
Coffee break
16.30 – 18.30 Head and Neck Cancer
Moderator: Piazza C, Lukšić I
Ostović KT
The importance of team work of cytologist and surgeon in preoperative diagnosis of intraoral minor salivary gland tumors
Petrović A, Petrović D, Stanković M, Vučković I
Update on imaging of head and neck paragangliomas
Vuong H, Awada T, Ringenbach P, Andreoletti JB, Saez P, Beck M
Thin skin grafted forehead flap with poached cartilage graft
Pastorčić Grgić M, Perše P, Tomičević T, Gršić K,
Šmalcelj J, Došen D
The place of modified radical neck dissection in head and neck squamous cell cancer treatment
Solter D, Vagić D, Zurak K, Ivkić M, Bedeković V
Gastric tube reconstruction in advanced tumors of the hypopharynx and cervical esophagus
Program
Vidjak V, Novačić K, Matijević F, Slavica M, Leder NI, Grubelić Crnčević M, Kavur L
Postirradiation carotid artery stenosis - Endovascular treatment with carotid artery stenting
Znaor T, Kuliš T, Pastorčić-Grgić M, Znaor A
Incidence and mortality trends of head and neck cancer in Croatia, 1988-2008
Paštar Z, Lipozenčić J
Dermoscopy of the melanocytic and non-melanocytic lesion
of the face and scalp
Bödeker L
SinuFIT / LaryngoFIT – the new concept of ENT instruments
from KARL STORZ
Friday, October 21, 2011
08.15 – 09.00
Instructional Courses
Uglešić V
Principles of Midface Reconstruction
Piazza C
Early laryngeal cancer diagnosis
Simo R
Treatment of advanced thyroid cancer
Ilić D
Basics in the surgical navigation
09.00 – 10.00
Modern Technologies
Moderator: Remacle M, Bilić M
Aubry K
Transoral robotic surgery for the treatment of head and neck cancer
Program
Kang SW
Robotic neck dissection for the management of thyroid
Janjanin S
Harmonic scalpel in head and neck surgery
10.00 – 10.30 Coffee break
10.30 – 12.30
Oral Cancer, panel discussion
Moderator: Virag M
Panelists: Cordeiro P, Shah J, Tachezy R, Bišof V
Shah J
Factors affecting treatment of cancer of the oral cavity
Tachezy R
HPV in the etiology of oral and oropharyngeal cancer
Cordeiro P
Reconstruction of the mandible with free tissue
transfer – outcomes and algorithm for flap selection
Virag M
Treatment of recurrent oral cancer
12.30 – 13.30 Lunch
Sponsored by Medtronic
13.30 – 15.00 Halder R
Autofluorescence Diagnostic in ENT
Head and Neck Surgery
Moderator: Eckel H, Leović D
Fliss D
Orbital tumors: Resection and reconstruction
Program
Jurlina M
Surgery of skull base tumors
Vagić D, Ivkić M, Zurak K, Solter D, Pegan A, Rašić I
A transmandibular approach for tumors of the parapharyngeal space
Čizmarevič B, Lanišnik B, Dinevski D
Cervical lymph node metastasis of squamous cell carcinoma from unknown primary tumor
Leović D, Zubčić V, Dinjar K
Distant metastases after the treatment of oral and oropharyngeal sqaumous cell cancer
15.00 – 15.30 Coffee break
15.30 – 17.30 Laryngeal cancer, round table
Moderator: Prgomet D
Panelists: Dietz A, Eckel H, Ivkić M, Remacle M, Rakušić Z
Dietz A
Nonsurgical larynx preservation therapy – what have we learned until today?
Eckel H
Surgical treatment of early-stage laryngeal carcinoma
Remacle M
Transoral robotic surgery for the management of laryngeal cancer
Program
Saturday, October 22, 2011
09.30 – 10.30 Thyroid surgery I
Moderator: Fliss D, Janušić R
Shah J
Changing epidemiology, management and outcomes in thyroid cancer
Chung WY
Robotic Thyroid Surgery: technique and outcomes
Radović D
PET/CT in management of thyroid malignancy - current status
10.30 – 11.00 Coffee break
11.00 – 12.30 Thyroid surgery II
Moderator: Jović MR, Vagić D
Simo R
Management of retrosternal goiters - To split or not to split!
Džepina D, Bedeković V, Čupić H, Krušlin B
Papillary thyroid microcarcinoma: clinical and pathological study
of 321 cases.
Salkić A, Brkić F, Čičkušić A, Čičkušić E, Altumbabić H
Thyroid cancer in Tuzla region of Bosnia and Herzegovina:
a 10-year study (1999-2008)
Pastorčić Grgić M, Stublja B, Gršić K, Janušić R,
Šmalcelj J, Došen D
Indications for reoperation in patients treated for well differentiated thyroid cancer
Alagić–Smailbegović J, Kucukalić–Selimović E, Šetić I, Bećirović M, Begović L
Importance of measurement of thyroglobulin and anti-
thyroglobulin antibodies in differentiated thyroid cancer
Poster session
Moderator: Đanić D, Čolović Z • Thursday, October 20, 2011, 14.00 – 15.00
Markov-Glavaš D, Makovac I, Jakovčević A
Acinic cell carcinoma of the parotid gland in a child
Džepina D, Kalogjera L, Baudoin T
Recurrent sinonasal melanoma – Report of five surgical cases
Boščić D, Vlašić, Frančeski D, Piskac-Živković N, Ožegović I, Kovačić J
Synovial sarcoma of the pharynx
Carić T, Bilić M, Kovač Bilić L, Kovačić J, Topić Grahovac I, Hutinec Z
Neuroendocrine tumors of larynx – two case reports and literature review
Roglić A, Šeronja Kuhar M, Markešić J
Chondroma of the larynx - case report
Bernić A, Novosel I, Križanac Š
The Dąbska tumor: a case report
Vukasović A, Kusačić Kuna S, Trutin Ostović K, Prgomet D, Banek T
Diffuse sclerosing variant of thyroid carcinoma presenting as Hashimoto thyroiditis: a case report
Jakovčević A, Hutinec Z, Žarković K, Duška Markov-Glavaš
Alveolar rhabdomyosarcoma of the parotid gland: a case report
Čandrlić B, Pušić M, Kukuljan M, Matana Z, Cvjetković N
Patient with lingual thyroid and squamous cell carcinoma of the tongue base: a case report
Boci B
Amyloidosis of the larynx
Boci B, Thomai K
Non-Hodgkin’s lymphomas of the parotid gland
Boci B, Zaharia K, Thomai K
Neurilemomas of the neck: case report
Pauzar B, Karner I, Glavaš-Obrovac Lj, Štefanić M, Dmitrović B
Pax8-pparγ oncogene in follicular thyroid tumors: rt-pcr and immunohistochemical analyses
Bumber B, Bilić M, Bura M, Prgomet D
Supracricoid partial laryngectomy - our experience
Filipović B, Pirkl I, Goranović T, Brkić I, Kovačić M, Šimunjak B
Paraneoplastic neurological syndrome with demyelinating polyradiculoneuropathy in tonsillar
carcinoma patient
Poster session
Marev D
An unusual cause of dysphonia: laryngeal verruca vulgaris
Marev D
Definitive radiotherapy for carcinoma in situ of the true vocal cords
Marev D
Nondiagnostic conjunctival map biopsies for sebaceous carcinoma
Sauerborn D, Pajić-Penavić I, Stojadinović T
Eosinophilic granuloma of the temporal bone in an adult: controversy in management
Müller D, Manojlović S, Lukšić I, Grgurević J
Calcifying epithelial odontogenic tumor of the maxilla
Đanić D, Đanić Hadžibegović A, Stojadinović T, Damjanović D, Gudelj A, Mahovne I
Harmonic scalpel surgical treatment of the tongue angioleomyoma - case report and review of the
literature
Pedisić D, Tićac R, Čandrlić B, Marijić B, Malvić G, Velepič M, Starčević R
The use of neck ultrasound to determine the length of a Provox II voice prosthesis
Leović D, Levanat S, Sabol M, Ozretić P, Sikora M
Hedgehog signaling pathway in oral and oropharyngeal squamous cell carcinomas
Klišeska E, Makovac I
Skip metastases in thyroid cancer
Košlabová E, Klozar J , Hamšíková E, Rotnáglová E, Saláková M, Tachezy R
Markers of HPV infection and their clinical relevance
Fustar-Preradović Lj, Đanic D, Kardum-Skelin I
Morphometry in differential diagnosis of pathologically altered parathyroid glands
Malvić G, Manestar D, Krstulja M, Čorak D, Čandrlić B, Kujundžić M, Velepič M, Starčević R
Juvenile angiofibroma of the maxillary sinus
Gršić K, Šitić S, Pastorčić Grgić M, Stubljar B, Perše P, Došen D
Merkel cell carcinoma of oral mucosa - case report
Vučinić I, Stojadinović T, Borić Mikez Z, Đanić D, Coha B
Apocrine carcinoma of the scalp with agressive clinical course – a case report and review of the literature
Lukšić I, Suton P, Manojlović S, Macan D, Dediol E
Pleomorphic adenoma in ectopic salivary gland tissue in the neck
Lukinović J, Bilić M, Raguž I, Živković T, Kovač Bilić L, Prgomet D
Overview of 100 patients with voice prosthesis after total laryngectomy – experience of single institutions
Poster session
Karadža- Lapić Lj, Karađole Č
Benign tracheal tumor: a case report
Širić Lj, Šoš D, Rosso M, Stevanović S
Objective assessment of tracheoesophageal and esophageal speech using acoustic analysis of voice
Marjanović Kavanagh M, Janjanin S, Hutinec Z
Cardiac metastases and a sudden death as a complication of advanced stage of head and neck
squamous cell carcinoma
Moderator: Stanković M, Znaor T • Friday, October 21, 2011, 13.00 – 14.00
Perić M, Miličić V, Pajter M, Marjanović K, Zubčić V
Potential value and disadvantages of fine needle aspiration cytology in diagnosis of ameloblastoma
Rosso M, Širić Lj, Tićac R, Starčević R, Šegec I, Kraljik N
Perceptual evaluation of alaryngeal speech
Rosso M, Kraljik N, Mihaljević I, Širić Lj, Šoš D, Vranješ Ž
Epidemiology of laryngeal cancer in Osijek - Baranja County (Eastern Croatia)
Snovak N, Bilić M, Žarković K
Merkel cell carcinoma: Report of three cases
Drviš P, Ries M, Zurak K, Trotić R, Ajduk J, Stevanović S
Hidradenoma of external auditory canal: Clinical presentation and surgical treatment
Slipac J, Janjanin S, Ljepava D, Hutinec Z, Bence-Žigman Z
Thyroid metastasis from breast carcinoma resembling medullary thyroid carcinoma. A case report
Starčević R, Marijić B, Manestar D, Pedisić D, Bonifačić D
Rare tumour of the epipharynx – case report
Tićac R, Čandrlić B, Juranić J, Pavelić G, Pedisić D, Pušić M, Starčević R
Videofluoroscopy and ultrasound role in assessment of laryngoesophageal muscle tonus after
laryngectomy
Tićac R, Živković Ivanović T, Kirinić Papeš V, Starčević R, Pedisić D, Vukelić J, Marijić B,
Velepič M, Čandrlić B,
Comparative acoustic analysis of Provox 2 and Provox Vega voice prosthesis
Rudeš M, Bilić M, Jurlina M, Prgomet D
Pectoralis major myofascial flap in reconstructive surgery of the head and neck – our experience
Ristić S
Holistic stimulating method in patients with total laryngectomy
Poster session
Grabovac S , Đanić Hadžibegović A , Markešić J
Inferior turbinate osteoma as a cause of unilateral nose obstruction – case report
Grabovac S, Cikoja I, Maličić Dalipi V, Čujić Lj, Planinić I
Minimally invasive surgery as a possibility of an atypical larynx carcinoid treatment.
Braut T, Kujundžić M, Vukelić J, Manestar D, Krstulja M, Starčević R, Grahovac B
Gene amplification of epidermal growth factor receptor in atypical glottic hyperplasia
Goranović T, Pirkl I, Filipović B, Parazajder D, Gudelj G, Šimunjak B
Diabetes mellitus, wound healing and wound infection in neck dissection
Bauer V, Alerić Z
Rare tumors of the head and neck found in the practice of Karlovac county hospital
otorhinolaringologysts
Orovčanec G
Lipoma sinus piriformis
Dediol E, Manojlović S, Tomasović Lončarić Č, Biočić J, Hat J
Inflammatory pseudotumor presenting as a facial swelling
Bišof V
ERCC1 expression in head and neck carcinoma treated with radiotherapy alone or cisplatin-based
concurrent chemoradiotherapy
Kukić Brusić S, Pušić M, Cvjetković N, Karnjuš R, Čandrlić B, Kukuljan, Matana Kaštelan Z,
Miletić D
Osteosarcoma of the mastoid process following radiation therapy of mucoepidermoid carcinoma of
the parotid gland – a case report
Makaruha K, Plaščak J, Lajtman Z, Kavur L, Bačić A
Giant parapharyngeal space lipoma: radiological findings and surgical approach
Birtić D, Včeva A, Kotromanović Ž, Zubčić Ž, Mihalj H, Jovanović S
Significance pepsin from saliva in diagnosis and treatment laryngopharyngeal reflux disease
Kotromanović Ž, Birtić D, Včeva A, Medić D, Zubčić Ž, Mihalj H, Kotromanović Z, Erić S,
Dmitrović B, Štefanić M
Non – functional parathyroid carcinoma – rare malignant tumor of the head and neck
Kotromanović Ž, Mihalj H, Zubčić Ž, Včeva A, Birtić D, Kotromanović Z, Rajc J
Angiosarcoma of the hypopharynx – a case report
General Information
Date & venue
October 20 – 22, 2011
Hotel Antunović, Zagrebačka avenija 100A
Zagreb, Croatia
Congress Language
The official language of the Congress is English
Thursday, October 20, 2011
Lecture Hall Schedule
Friday, October 21, 2011
Instructional Courses
HALL BEETHOVEN 1
HALL BEETHOVEN 1
3 sections of HALL TOMISLAV
Oral cancer, panel discussion
HALL BEETHOVEN 1
Head and Neck Surgery
HALL BEETHOVEN 1
Laryngeal cancer, round table
HALL TOMISLAV
Saturday, October 22, 2011
HALL BEETHOVEN 1
Poster Session (Thursday and Friday)
HALL BEETHOVEN 3
CME Accreditation
Congress will be accredited by Croatian Medical Chamber
Registration fee includes
Admission to all Congress sessions, posters, instructional courses and exhibition areas, Certificate
of Attendance, Welcome cocktail, Congress coffee breaks and lunches, Congress bag
and material
All papers accepted after a review process will be published in issue of Collegium
Antropologicum as abstracts or full text articles.
Oral presentation will be 8 minutes and invited lectures 20 and 30 minutes long.
The poster session will be guided, meaning that the poster presenting authors will have to
present the content of their poster to the Chairpersons.
Registration desk will be open every day from 7.30 am.
You can apply for Instructional courses at the registration desk.
There is a limitation of maximum 15 participants per Course
Website
www.tumoriglave.com
Tehnical Organizer
FILIDA TRAVEL AGENCY
Selska 92 b, 10 000 Zagreb
Office hours:
monday – friday
09 -17
850.00 KN per persone per night in 1/1 room
530.00 KN per persone per night in 1/2 room
Phone: +385 1 4616 520/522
Fax: +385 1 4616 521
e-mail: [email protected]
web: www. filidatravel.hr
RAIFFEISEN BANK:
2484008-1101947031
IBAN: HR0524840081101947031
SWIFT: RZBHHR2X
* registration fee can be paid to the bank account of the Technical Organizer
**in the field payment purpose please write „registration fee for Head and Neck Congress“
For each individual accommodation we recommend you to contact
FILIDA TRAVEL AGENCY.
ENDOSCOPY DEVICES
Ultrasound system
The special ultrasound scissors for thyroid surgery
Minimally-invasive procedures compete with conventional routes
of access in virtually every indication in visceral surgery; in many
diseases (such as cholecystolithiasis), they themselves have become
the standard procedure. In thyroid surgery, various minimallyinvasive access routes have been developed over the past decade.
The cosmetic benefits and reduced post-operative strain on the
patient lead to the increasing importance of minimally-invasive
procedures of the thyroid glands.
Rješenje za oči i nos
AVYS-11/05/2011-ADV
CRO/FF/0006/11
Iz bilo kojeg razloga
U bilo kojoj sezoni
Sastavni dio ovog materijala predstavlja odobreni Sažetak opisa
svojstava lijeka, sukladno Pravilniku o načinu oglašavanja o
lijekovima i homeopatskim proizvodima, Narodne novine br. 118/09.
Prije propisivanja lijeka, molimo pročitajte zadnji odobreni Sažetak
opisa svojstava lijeka i Uputu o lijeku.
Samo za zdravstvene radnike.
AVAMYS
SKRAĆENI SAŽETAK OPISA SVOJSTAVA LIJEKA. NAZIV LIJEKA AVAMYS 27,5 mikrograma/
potisnoj dozi Sprej za nos, suspenzija KVALITATIVNI I KVANTITATIVNI SASTAV Jedna potisna
doza spreja sadrži 27,5 mikrograma flutikazonfuroata. Terapijske indikacije Odrasli, adolescenti
(12 i više godina) i djeca (6-11 godina) Avamys se primjenjuje u liječenju simptoma alergijskog
rinitisa. Doziranje i način primjene Odrasli i adolescenti (12 i više godina): Preporučena početna
doza je dvije inhalacije spreja jednom na dan (27,5 mikrograma flutikazonfuroata po svakoj
inhalaciji spreja) u svaku nosnicu (ukupna dnevna doza 110 mikrograma). Djeca (6 do 11 godina):
Preporučena početna doza je jedna inhalacija spreja (27,5 mikrograma flutikazonfuroata po svakoj
inhalaciji spreja) u svaku nosnicu jednom na dan (ukupna dnevna doza 55 mikrograma). Djeca
ispod 6 godina starosti: Iskustvo primjene lijeka u djece ispod 6 godina starosti je ograničeno (vidi
poglavlje 5.1 i 5.2). Sigurnost i učinkovitost primjene lijeka u ovoj skupini nisu dobro utvrđene.
Kontraindikacije Preosjetljivost na djelatnu tvar ili neku od pomoćnih tvari lijeka Avamys.
Posebna upozorenja i mjere opreza Flutikazonfuroat prolazi ekstenzivni metabolizam prvog
prolaza te je stoga vjerojatno povećanje sistemske izloženosti intranazalnom flutikazonfuroatu kod
bolesnika s teškim oboljenjem jetre, što može rezultirati većom učestalošću sistemskih nuspojava
(vidi poglavlje 4.2 i 5.2). Savjetuje se oprez u liječenju spomenutih bolesnika. Može doći do pojave
sistemskih učinaka nazalno primjenjenih kortikosteroida, osobito pri visokim dozama propisanima
u produljenom razdoblju. Ovi učinci variraju među bolesnicima i različitim kortikosteroidima (vidi
poglavlje 5.2). Liječenje višim dozama nazalno primjenjenih kortikosteroida od preporučenih može
imati za posljedicu klinički značajnu adrenalnu supresiju. Ako postoji dokaz o primjeni viših doza
od preporučenih, potrebno je razmotriti dodatnu zaštitu od sistemskih kortikosteroida tijekom
stresnih razdoblja ili elektivnih kirurških zahvata. Flutikazonfuroat 110 mikrograma jednom na
dan nije bio povezan sa supresijom osovine hipotalamus-hipofiza-nadbubrežna žlijezda (HPA) kod
subjekata odrasle, adolescentske i dječje dobi. Međutim, potrebno je smanjiti intranazalnu dozu
flutikazonfuroata na najnižu dozu kojom se učinkovito održava kontrola simptoma rinitisa. Avamys
sadrži benzalkonij klorid, koji može izazvati iritaciju sluznice nosa. Nuspojave Poremećaji dišnog
sustava, prsišta i sredoprsja Vrlo često: epistaksa. Često: ulceracija nosa. Epistaksa je općenito
bila blagog do umjerenog intenziteta. Kod odraslih i adolescenata, stopa incidencije epistakse bila
je viša u dugotrajnoj primjeni (dulje od 6 tjedana) nego u kratkotrajnoj primjeni (do 6 tjedana).
U pedijatrijskim kliničkim ispitivanjima, u trajanju do 12 tjedana, stopa incidencije epistakse bila je
slična između bolesnika koji su primali flutikazonfuroat i bolesnika koji su primali placebo. Sadržaj
pakiranja Avamys sprej za nos je plastična naprava žućkastobijele boje, s otvorom dozirnog
indikatora, svijetloplavom bočnom ručicom za aktivaciju i poklopcem koji sadrži čep. Plastična
naprava sadržava sprej za nos u obliku suspenzije u smeđoj (staklenoj) bočici tipa I, s odmjernom
pumpicom raspršivača. Lijek je dostupan u veličini pakiranja: 120 doza. NOSITELJ ODOBRENJA
GlaxoSmithKline d.o.o., Livadarski put 7, 10 000 Zagreb. KLASA RJEŠENJA O ODOBRENJU
ZA STAVLJANJE GOTOVOG LIJEKA U PROMET UP/I-530-09/08-01/344. NAČIN IZDAVANJA
Samo na liječnički recept. DATUM PRVOG ODOBRENJA/OBNOVE ODOBRENJA 04. lipnja 2009.
(ALMP-06/2009). Sastavni dio ovog promotivnog materijala predstavljaju i cjelokupni
odobreni Sažetak opisa svojstava lijeka sukladno pravilniku o načinu oglašavanja o lijekovima
i homeopatskim proizvodima, Narodne novine br. 118/09. Prije propisivanja lijeka, molimo
pročitajte zadnji odobreni Sažetak opisa svojstava lijeka i Uputu o lijeku.
PLATINUM SPONSORS GOLDEN SPONSOR
iga d.o.o.

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