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Adriano Casulli. HERACLES - Istituto Superiore di Sanità

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26/05/2014
GP/EFSA/AHAW/2012/01:
Echinococcus multilocularis infection in animals
To prepare for the future opinion (EU regulation 1152/2011):
GP/EFSA/AHAW/2012/01:
Echinococcus multilocularis infection in animals
THE AIM:
• Identify and collate the current knowledge and data on
9 Epidemiological points;
• Apply systematic reviews of literature and data.
HERACLES
Adriano Casulli
European Reference Laboratory for Parasites
Istituto Superiore di Sanità (Rome, Italy)
1
26/05/2014
H.E.R.A.C.L.E.S.
The EC launched a SPECIFIC CALL
(First Time!!) on neglected infectious
diseases.
Human cystic Echinoccosis ReseArch in
CentraL and Eastern Societies
• THEME: HEALTH.2013.2.3.4-1: Neglected
infectious diseases of Central and Eastern Europe
• FUNDING SCHEME: Collaborative Project.
• THE AIM: establish an integrated approach for the development of preventive,
therapeutic and diagnostic tools for NID. This action support innovative,
collaborative biomedical research proposals. Focus on one or more viral, bacterial,
protozoan, and/or helminthic human diseases.
P
LEGAL NAME
ACRONYM
TYPE
COUNTRY
Principal Investigator
1 ISTITUTO SUPERIORE di SANITÀ
ISS
Research Institute
ITALY
DR. ADRIANO CASULLI
2
UNIVERSITÀ di PAVIA
UNIPV
University
Hospital
ITALY
Dr. Enrico Brunetti
3
AGENCIA ESTATAL CONSEJO SUPERIOR de INVESTIGACIONES CIENTÍFICAS
CSIC
Research Institute
SPAIN
Dr. Maria del Mar Siles‐Lucas
4
SPITALUL CLINIC COLENTINA BUCURESTI
CCHUMFCD
University
Hospital
ROMANIA
Prof. Carmen Michaela Cretu
5
HACETTEPE UNIVERSITESI
HUSMDR
University
Hospital
TURKEY
Prof. Okan Akhan
6
HOSPITAL for ACTIVE TREATMENT of INFECTIOUS and PARASITIC DISEASES "PROF. I. KIROV”
SHATIPD
University
Hospital
BULGARIA
Prof. Kamena Vutova
10
NAMIK KEMAL UNIVERSITESI
NKU
University
TURKEY
Prof. Gulay Vural
8
ALTA Ricerca e Sviluppo
in Biotecnologie S.R.L.U.
ALTA
Service
provider company
ITALY
Dr. Aldo Tagliabue
9
VIRCELL S.L.
VIRCELL
S.M.E.
SPAIN
Dr. Arantxa
Cortes Ruiz
Timing: 1st October, 2013 - 2017
2
26/05/2014
Consortium and Centres involved
in the “Extended Family”
Countries of origin of the Consortium
HERACLES governance
WP4
CE ultrasound
screening
WP1
Enantiomeric
drug
development
WP5
ERCE
registry
WP6
Management
and IPR
Training and
dissemination
Host-parasite
interplay
EchinoBioBank
WP3
WP2
New molecular
based tools
3
26/05/2014
Themain
mainGOALS
GOALSof
ofHERACLES
HERACLESare:
are:
The
The main GOALS of HERACLES are:
• Identify the EEC population affected by CE by ultrasound screening;
• Set-up and validate new molecular-based PoC-LoC
immunological surveillance, rapid diagnosis and follow-up;
kits
for
• Create the European Registry of Cystic Echinococcosis (ERCE) for the
surveillance of CE to provide baseline data for risk calculations and to
establish a prospective case retrieval;
• Establish the Echino-Bio-Bank from animal and human CE patients
and related Databases;
• Identify the molecular bases associated with CE response to therapy
or lack thereof, through the of host-parasite interplay (omic studies);
HUMAN
IMMUNITY
PARASITE
VIRULENCE
CLINICAL
RECORDS
The main GOALS of HERACLES are:
ERCE
REGISTRY
• Increase drug bioavailability of ABZ in an in vivo model and to
synthesize a new enantiomeric drug based on ABZ;
O
CE ULTRASOUND
SCREENING
O
H
N
S
*
HOSPITAL
NETWORK
O
N
H
N
(+)-(R)-ABZ-SO
O
S
*
HUMAN SAMPLES
COLLECTION
O
H
N
O
N
H
N
(-)-(S)-ABZ-SO
• Train people working in EEC, as they are crucial to fight this disease.
Dissemination: EU citizens; experts; public health authorities; policy makers.
Training: staff exchange; ultrasound on CE, PAIR and related techniques; Laboratory
techniques; educational events.
ANIMAL SAMPLES
COLLECTION
ECHINO-BIO-BANK
IN VIVO ANIMAL
MODEL
VALIDATION of
MOLECULAR TOOLS
ABZ BIOAVAILABILITY
and ENANTIOMERIC
DRUG SYNTHESIS
COMMERCIAL
POC-LOC KIT
HOST-PARASITE
INTERPLAY
4
26/05/2014
More info: http://www.Heracles-fp7.eu/
......is growing!
Any lessons learned are likely to be applicable and useful for other countries, especially in
the underserved areas, where CE represents an important health problem.
5
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