Brain activation for response inhibition under gaming cue distraction

医療情報システム研究室
NIRS 認知負荷班
【文献調査】
Brain activation for response inhibition under gaming
cue distraction in internet gaming disorder
杉田 出弥
廣安 知之
山本 詩子
2014 年 05 月 09 日
タイトル
1
インターネットゲーム障害におけるゲーム娯楽下の反応抑制による脳活動
著者
2
Gin-Chung Liua, Ju-Yu Yenc, Chiao-Yun Chena, Cheng-Fang Yenc, Cheng-Sheng Chenc, Wei-Chen Lina,
Chih-Hung Ko
出典
3
The Kaohsiung Journal of Medical Sciences, Volume 30, Issue 1, January 2014, Pages 43?51
アブストラクト
4
私達はインターネット障害の大学生において神経物質と制御欠如との関係性を調査している.ゲーム娯楽時の
反応抑制機能が不足することによってインターネット利用能力の欠如が起こると仮定した.インターネット障害
の 11 人の被験者はゲーム状況下である場合とない場合の 2 条件において fMRI 内で GO/NOGO 課題を行った.
ゲーム画面が個人が課題を行う背景にある見られる場合,インターネット障害グループは命令エラーを起こした.
統制ができるグループは IGD グループと比較してゲーム環境下において DLPFC と上頭頂小葉がより活性した.
さらにこれらの部位の脳活動は IGD グループ間で反応抑制のパフォーマンスと反対の関係性を示した.この結果
から反応抑制機能は IGD グループ間でゲーム娯楽下において正常に機能していないことや,IGD の被験者たちは
ゲーム環境下において反応抑制のための注意の配分や認知制御を保つために DLPFC や上頭頂小葉を活動させる
ことができなかったことが示唆される.このメカニズムは IGD が関わるあらゆる場面において取り入れられるべ
きである.
参考文献
5
5.1
インターネット依存性が世界で広まっている.
[1] Ko CH, Yen JY, Chen SH, Yang MJ, Lin HC, Yen CF. Proposeddiagnostic criteria and the screening and
diagnosing tool of Internet addiction in college students. Compr Psychiatry2009;50:378-84.
[2] Siomos KE, Dafouli ED, Braimiotis DA, Mouzas OD, Angelopoulos NV. Internet addiction among Greek
adolescent students. Cyberpsychol Behav 2008;11:653-7.
[3] Zhang L, Amos C, McDowell WC. A comparative study of Internet addiction between the United States
and China. Cyberpsychol Behav 2008;11:727-9.
[4] Yen JY, Ko CH, Yen CF, Chen CS, Chen CC. The association between harmful alcohol use and Internet
addiction among college students: comparison of personality. Psychiatry Clin Neurosci 2009;63:218-24.
5.2
インターネット依存性は年齢による物質使用の違いに関係している.
[5] Ko CH, Yen JY, Yen CF, Lin HC, Yang MJ. Factors predictive for incidence and remission of internet
addiction in young adolescents: a prospective study. Cyberpsychol Behav 2007;10:545-51.
[6] Holden C.‘ Behavioral ’addictions: do they exist? Science 2001;294:980-2.
[7] Bai YM, Lin CC, Chen JY. Internet addiction disorder among clients of a virtual clinic. Psychiatr Serv
2001;52:1397.
1
[8] Ko CH, Yen JY, Chen CC, Chen SH, Wu K, Yen CF. Tridimensional personality of adolescents with
internet addiction and substance use experience. Can J Psychiatry 2006;51:887-94.
[9] Ko CH, Yen JY, Yen CF, Chen CS, Weng CC, Chen CC. The association between Internet addiction and
problematic alcohol use in adolescents: the problem behavior model. Cyberpsychol Behav 2008;11:571-6.
5.3
インターネット依存性の脳活動は物質中毒時と似ている.
[10] Ko CH, Liu GC, Hsiao S, Yen JY, Yang MJ, Lin WC, et al. Brain activities associated with gaming urge
of online gaming addiction. J Psychiatr Res 2009;43:739-47.
5.4
反応抑制は制御不能を説明するための大切な概念である.
[11] Goldstein RZ, Volkow ND. Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am J Psychiatry 2002;159:1642-52.
5.5
反応抑制は GO/NOGO 課題で計測される.
[12] Kaufman JN, Ross TJ, Stein EA, Garavan H. Cingulate hypoactivity in cocaine users during a GO-NOGO
task as revealed by event-related functional magnetic resonance imaging. J Neurosci 2003;23:7839-43.
[13] Hester R, Garavan H. Executive dysfunction in cocaine addiction: evidence for discordant frontal, cingulate, and cerebellar activity. J Neurosci 2004;24:11017-22.
[14] Fu LP, Bi GH, Zou ZT, Wang Y, Ye EM, Ma L, et al. Impaired response inhibition function in abstinent
heroin dependents: an fMRI study. Neurosci Lett 2008;438:322-6.
5.6
若者のインターネット依存性患者は GO/NOGO 課題時のエラー率が高い.
[15] Cao F, Su L, Liu T, Gao X. The relationship between impulsivity and Internet addiction in a sample of
Chinese adolescents. Eur Psychiatry 2007;22:466-71.
5.7
インターネット依存性患者の中でも良い課題パフォーマンスを示す人がいる.
[16] Sun DL, Chen ZJ, Ma N, Zhang XC, Fu XM, Zhang DR. Decisionmaking and prepotent response
inhibition functions in excessive internet users. CNS Spectr 2009;14:75-81.
5.8
大人のインターネット依存性患者でストループ課題時に前帯状皮質で脳活動が増加したという報告が 1 件
ある.
[17] Dong G, Devito EE, Du X, Cui Z. Impaired inhibitory control in ’internet addiction disorder ’: a
functional magnetic resonance imaging study. Psychiatry Res 2012;203:153-8.
5.9
反応抑制の管理能力は成長とともに発達する.
[18] Andrews-Hanna JR, Mackiewicz Seghete KL, Claus ED, Burgess GC, Ruzic L, Banich MT. Cognitive
control in adolescence: neural underpinnings and relation to selfreport behaviors. PLoS One 2011;6:e21598.
5.10
物質による認識の制御について
[19] Field M, Cox WM. Attentional bias in addictive behaviors: a review of its development, causes, and
consequences. Drug Alcohol Depend 2008;97:1-20.
[20] Hester R, Garavan H. Neural mechanisms underlying drugrelated cue distraction in active cocaine users.
Pharmacol Biochem Behav 2009;93:270-7.
[21] Potenza MN, Steinberg MA, Skudlarski P, Fulbright RK, Lacadie CM, Wilber MK, et al. Gambling urges
in pathological gambling: a functional magnetic resonance imaging study. Arch Gen Psychiatry 2003;60:828-36.
[22] Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International
Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric
interview for DSM-IV and ICD-10. J Clin Psychiatry 1998;59(Suppl. 20):22-57.
[23] Chen SH, Weng LC, Su YJ, Wu HM, Yang PF. Development of Chinese Internet Addiction Scale and
Its Psychometric study. Chinese J Psychology 2003;45:279-94 [In Chinese].
[24] Heatherton TF, Kozlowski LT, Frecker RC, Fagerstro¨m KO. The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire. Br J Addict 1991; 86:1119-27.
[25] Rorden C, Brett M. Stereotaxic display of brain lesions. Behav Neurol 2000;12:191-200.
[26] Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain. New York: Georg Thieme
2
Verlag/Thieme Medical Publishers; 1998.
[27] Lancaster JL, Woldorff MG, Parsons LM, Liotti M, Freitas CS, Rainey L, et al. Automated Talairach
atlas labels for functional brain mapping. Hum Brain Mapp 2000;10:120-31.
[28] Hueteel SA, Song AW, McCarthy G. Funtional magnetic resonance imaging. Sunderland, MA: Sinauer
Associates; 2004.
[29] Brett M, Anton JL, Valabregue R, Poline JB. Region of interest analysis using an SPM toolbox. 8th
International Conference on Functional Mapping of the Human Brain; 2002.
[30] Forman SD, Dougherty GG, Casey BJ, Siegle GJ, Braver TS, Barch DM, et al. Opiate addicts lack
error-dependent activation of rostral anterior cingulate. Biol Psychiatry 2004;55: 531-7.
[31] Lee TM, Zhou WH, Luo XJ, Yuen KS, Ruan XZ, Weng XC. Neural activity associated with cognitive
regulation in heroin users: a fMRI study. Neurosci Lett 2005;382:211-6.
[32] Li CS, Luo X, Yan P, Bergquist K, Sinha R. Altered impulse control in alcohol dependence: neural
measures of stop signal performance. Alcohol Clin Exp Res 2009;33:740-50.
[33] Noe¨l X, Van der Linden M, d ’Acremont M, Bechara A, Dan B, Hanak C, et al. Alcohol cues increase
cognitive impulsivity in individuals with alcoholism. Psychopharmacology (Berl) 2007;192:291-8.
[34] Liddle PF, Kiehl KA, Smith AM. Event-related fMRI study of response inhibition. Hum Brain Mapp
2001;12:100-9.
[35] Menon V, Adleman NE, White CD, Glover GH, Reiss AL. Errorrelated brain activation during a Go/NoGo
response inhibition task. Hum Brain Mapp 2001;12:131-43.
[36] Asahi S, Okamoto Y, Okada G, Yamawaki S, Yokota N. Negative correlation between right prefrontal
activity during response inhibition and impulsiveness: a fMRI study. Eur Arch Psychiatry Clin Neurosci
2004;254:245-51.
[37] Hoshi E. Functional specialization within the dorsolateral prefrontal cortex: a review of anatomical and
physiological studies of non-human primates. Neurosci Res 2006;54: 73-84.
[38] Mobbs D, Eckert MA, Mills D, Korenberg J, Bellugi U, Galaburda AM, et al. Frontostriatal dysfunction
during response inhibition in Williams syndrome. Biol Psychiatry 2007;62:256-61.
[39] Li CS, Sinha R. Inhibitory control and emotional stress regulation: neuroimaging evidence for frontallimbic dysfunction in psycho-stimulant addiction. Neurosci Biobehav Rev 2008; 32:581-97.
[40] Dolcos F, Diaz-Granados P, Wang L, McCarthy G. Opposing influences of emotional and non-emotional
distracters upon sustained prefrontal cortex activity during a delayedresponse working memory task. Neuropsychologia 2008;46: 326-35.
[41] Toepper M, Gebhardt H, Beblo T, Thomas C, Driessen M, Bischoff M, et al. Functional correlates of
distractor suppression during spatial working memory encoding. Neuroscience 2010;165:1244-53.
[42] Burgess GC, Depue BE, Ruzic L, Willcutt EG, Du YP, Banich MT. Attentional control activation relates
to working memory in attention-deficit/hyperactivity disorder. Biol Psychiatry 2010;67:632-40.
[43] Ko CH, Yen JY, Chen CS, Chen CC, Yen CF. Psychiatric comorbidity of internet addiction in college
students: an interview study. CNS Spectr 2008;13:147-53.
[44] Halari R, Kumari V. Comparable cortical activation with inferior performance in women during a novel
cognitive inhibition task. Behav Brain Res 2005;158:167-73.
[45] Tapert SF, Schweinsburg AD, Drummond SP, Paulus MP, Brown SA, Yang TT, et al. Functional MRI
of inhibitory processing in abstinent adolescent marijuana users. Psychopharmacology (Berl) 2007;194:173-83.
[46] Ciaramelli E, Grady CL, Moscovitch M. Top-down and bottomup attention to memory: a hypothesis
(AtoM) on the role of the posterior parietal cortex in memory retrieval. Neuropsychologia 2008;46:1828-51.
[47] Kim SY, Hopfinger JB. Neural basis of visual distraction. J Cogn Neurosci 2010;22:1794-807. [48] McRae
K, Hughes B, Chopra S, Gabrieli JD, Gross JJ, Ochsner KN. The neural bases of distraction and reappraisal.
J Cogn Neurosci 2010;22:248-62.
[49] Kanai R, Dong MY, Bahrami B, Rees G. Distractibility in daily life is reflected in the structure and
function of human parietal cortex. J Neurosci 2011;31:6620-6.
[50] Field M, Munafo‘ MR, Franken IH. A meta-analytic investigation of the relationship between attentional
bias and subjective craving in substance abuse. Psychol Bull 2009;135: 589-607.
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