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Notch Signaling
Hedgehog Signaling
JAG/Serrate
DLL
JAG/Serrate
DLL
Signal sending cell
G
CER1
HhN
Ligand degradation
or recycling
NECD
PKA
GSK3β
Notch
P
NICD
S1 cleavage
On-State
SuFu
Gli 1/2/3
SMURF2
SMURF1
GSK3β P
P
P
PP2A Axin
Smad2/3
Smad1/5/8
APC β-Catenin
Smad4
Smad4
FBXW11
P P
CK 1
β-Catenin
P
Gli 1/2
Txn
activator
Ub Ub
Ub Ub Ub
Notch
FBXW11
β-Catenin
Proteosomal degradation
Gli 1/2
Gli 3
O-FUT
Txn repressor
HATs
MAML
CSL
SKIP
Gli 3
Wnt
Gli1
CycD1
Myc
Nucleus
Expression
P
PYGO β-Catenin
BCL9 TCF/LEF
Patched
Igf2
Cyclin E SOX17
BMPs
P
NLK CTBP
Myc
Axin
CyclinD1
DKK1
TGF-1
CD44
WISP1
MMP-7
P
Smad1/5/8
Smad4
CBP
Smad2/3
Smad4
CBP
Transcription Factors
Ligands, Growth Factors, Etc.
Membrane Receptors
Kinases
Phosphatases
Cellular Proteins
Signal Transducers
Txn Regulators
Stem Cell Marker Antibody Packs
#NBP1-42823
Pluripotent Stem Cell Transcription Factor Antibody Pack
#NBP1-42824
Essential iPSC Factor Antibody Pack
#NBP1-42825
Human ESC Marker Antibody Pack
#NBP1-42826
Neural Stem Cell Marker Antibody Pack
Stem Cell Lines
#NBP1-49595
CL-01 Human B Cell Line
#NBP1-41162
v6.5 Mouse Embryonic Stem Cell Line
#NBA1-19349
DGCR8 Knockout Mouse Embryonic Stem Cell Line
#NBP1-96751
Dicer Knockout Mouse Embryonic Stem Cell Line
Stem Cell Growth Support
#U0019
Stematrix
#NBP1-78301
Laminin Protein for Neurite Growth Substratum
Proteases
[メーカー:NOV]
:
Self-Renewal Cell-Fate Determination
䊜䋣
䉴
Stem Cell Antibodies
䉥䉴
NB110-56924 㨯 beta Catenin
NBP1-19751 㨯 BMP2
NBP1-71663 㨯 CD31/PECAM1
NB600-1071 㨯 CD34
NBP1-78292 㨯 Notch1
NB110-56923 㨯 Sonic Hedgehog
• 14-3-3 gamma
• Angiopoietin 1
• beta Catenin
• BMP
• CD31/PECAM1
• CD34
• c-Myc
• CXCR4
• DKK
• EGF
• EPH Receptor B3
• FGF
• GFAP
• IGF
• Jagged1
• Musashi 1
• N Cadherin
• Nestin
• Noggin
• Notch
• OCT4
• PI3K
• PTEN
• SDF1
• SFRP
• SMAD4
• Sonic Hedgehog
• SOX2
• SSEA1
• SSEA3
• STRO-1
• TCF4
• TGF alpha
• TGF beta
• TIE2
• TRA-1-60 (R)
• TRA-1-81
• VEGF
• WIF1
• Wnt
本 紙 に 掲 載 さ れ て い る製品はすべて研究用です
PreTα
Myc
p21
MASH-1
Expression
Expression
Expression
Gli 1/2
CTBP
お問い合わせ先 試薬
- 684 1
- 620
- 684 1
- 775
TEL 03 5
FAX 03 5
Hes 1/3/5
Hey1/2
MAG
CNPase
ICAT
Expression
NICD
SKIP HDAC
SMRT CSL CTBP
SHARP CIR
23
Smad6/7
DVL
FRAT
Akt
P
βTrCp
Gli 1/2/3
Smad2/3
P
CK1
P
Smad1/5/8
P
NKD
Off-State
G
Type I R
Type II R
P
Cos2
Fu SuFu
Gli 1/2/3
Notch
BMP
Wnt
FZD
BMPR1
BMPR2
LRP5/6
BOC
CDON
NEXT
NCSTN
PEN2
Notch
γ-Secretase
complex
S3 cleavage
Lefty
Activin Nodal
Noggin
FRP
DKK1
HhN
Patched SMO
G
G
FST
CHRD
HhN
Deltex
ER
Wnt
BMP
PSEN1/2 APH1
Furin
BMP/Activin/Nodal
Signaling
WIF
Dispatchted
DVL
Fringe
Figure:Stem Cell Signal Pathway
Wnt Signaling
Hedgehog
ER/Golgi
G
NUMB
Adam17
G
G
S2 cleavage
G
Golgi
幹細胞特集
フナコシニュース 2014 年 3 月 1 日号(No.560)
funakoshi news
※大きなサイズで印刷できる PDF を,フナコシホームページ(http://www.funakoshi.co.jp/catalogs)からダウンロードできます!
140301s_p23_i.indd 23
2014/02/17 15:57:04