Phosphodiesterase Enzyme (PDE) Inhibitors Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2025

PHOSPHODIESTERASE ENZYME
(PDE) INHIBITORS MARKET
Global Industry Insights, Trends, Outlook, and
Opportunity Analysis, 2016-2024
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REPORT DESCRIPTION
Phosphodiesterase Enzyme (PDE) Inhibitors Market Overview
Phosphodiesterase are a diverse family of enzymes (11 isoenzymes) that play a key role in
regulating intracellular levels of secondary messengers - cyclic adenosine monophosphate
(cAMP) and cyclic guanosine monophosphate. These enzymes identified to be
pharmacologically active in the 1950s, hydrolyses cyclic nucleotides to treat various diseases
such as cardiovascular, respiratory and erectile dysfunction. Distinct distribution of all the types
of isoenzymes has provided possibilities for selective target therapies.
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The global phosphodiesterase enzyme inhibitors market can be better analyzed by classifying it
into two classes as selective phosphodiesterase enzyme inhibitors and non-selective
phosphodiesterase enzyme inhibitors. Theophylline and papaverineare the two most commonly
used non-selective phosphodiesterase enzyme inhibitors for treating a range of diseases
(bronchodilation, cardiac disorder, etc.). Advent of selective phosphodiesterase enzyme
inhibitors has made a great impact in the medical treatment sector. Increasing understanding of
the individual PDE isoforms has and will result in the emergence of better therapeutic drugs.
Viagra (Sildenafil) is the best example to substantiate the success and impact of PDE inhibitors.
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REPORT DESCRIPTION
Increasing product developments to further improvise the phosphodiesterase enzyme inhibitors
market outlook
The global phosphodiesterase enzyme inhibitors market has recently gained traction on account of the
blockbuster PDE 5 inhibitor brands, Viagra and Cialis. This has also encouraged pharmaceutical
companies to research on other PDE inhibitor class. In addition, research on extended use of approved
PDE inhibitors is anticipated to benefit the drug in long term and contribute to the increasing revenues
of PDE inhibitors market.
Researchers from the John Hopkin University reviewed the trials of PDE-5 inhibitors in pediatric patients
with pulmonary hypertension. The researchers concluded that PDE-5 inhibitors can be safely prescribed
to infants, neonates and children with primary and secondary pulmonary hypertension (2017).
Besides, PDE-5 inhibitor sildenafil accidently developed for treating angina, was also found to be
effective in erectile dysfunction and now is observed to benefit heart attack patients. Researchers at
Karolinska Institutet, Sweden reported in March 2017 that PDE-5 inhibitors prescribed for erectile
dysfunction can lower the risk of death of hospitalization for heart failure in men who have had one
heart attack in their lifetime.
Pfizer, Inc. received FDA approval for its PDE-4 inhibitor Crisaborole (Eucris) in December 2016 for the
treatment of mild to moderate atopic dermatitis. Eucrisa the first non-steroidal topical monotherapy for
skin disorder.
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Many such product developments would be augmenting the global PDE inhibitors market
growth in near future.
New products are primarily targeted in develop economies like North America, Europe and
Japan. However, product approval in emerging nations such as India, China, Brazil, Russia,
Argentina, and Indonesia would potentially favorable for the market players. Increasing
healthcare expenditure and large target population base would support the growth of
PDE inhibitors market in these nations. However, market players need to be cautious about
uncertain regulatory conditions favoring the economic status and healthcare need of the large
patient population.
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Some of the key players operating in the global phosphodiesterase enzyme inhibitors market
include Pfizer, Inc., AstraZeneca plc, Bayer AG, Eli Lilly & Company, Celgene Corporation, Mist
Pharmaceuticals.
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Phosphodiesterase are a diverse family of enzymes (11 isoenzymes) that play a key role in regulating intracellular levels of secondary messengers - cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate. These enzymes identified to be pharmacologically active in the 1950s, hydrolyses cyclic nucleotides to treat various diseases such as cardiovascular, respiratory and erectile dysfunction. Distinct distribution of all the types of isoenzymes has provided possibilities for selective target therapies. Request Sample Copy of the Business Report: https://www.coherentmarketinsights.com/insight/request-sample/172