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Annals of Medical and Biomedical Sciences (AMBS)


16 documents

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Serum lactate levels in Libyan patients with type 2 diabetes mellitus receiving metformin therapy
Serum lactate levels in Libyan patien...Health and Medicinediseases

Objective: Metformin is the most widely prescribed anti-hyperglycemic agent. It has been linked to the de-velopment of lactic acidosis. However the incidence of this condition is thought to be very low in metformin-treated patients. The aim of this study to assess the levels of serum lactate in metformin-treated patients with type 2 diabetes. Methods: Thirty patients with type 2 diabetes receiving metformin therapy were recruited to the study from outpatients attending Benghazi Diabetes Center. Thirty age-matched and sex-matched healthy controls were selected for comparison. Serum lactate was determined in both groups Results: Metformin-treated patients with type 2 diabetes had higher mean serum lactate levels compared with age-matched and sex-matched healthy subjects (1.87 mmol/l vs 1.49 mmol/l, P <0.05). There is no effect of duration of treatment or the dose of metformin on serum lactate. Conclusions: Metformin therapy is associated with small increase in serum lactate levels that seems to be dose-independent and not affected by treatment duration. This increase is far less than the levels known to be associated with lactic acidosis  

01 апреля 2015
The comparison of tissue IL-22 levels between Psoriasis and Vitiligo patients
The comparison of tissue IL-22 levels...Health and Medicinediseases

Objective: Interleukin (IL)-22 is a cytokine that is involved in the modulation of tissue remodeling during inflammation. Different types of T cells secrete IL-22. IL-6 and tumor necrosis factor α (TNF-α) induce Th22 cells to produce IL-22, particularly in the skin, whereas γδ T cells produce IL-22 in response to IL-23, particularly in the lung. IL-22 is known to be expressed in many chronic inflammatory conditions, including several skin diseases. This study was planned to comparison the role of IL-22 receptor type 1 (IL-22R1) between psoriasis and vitiligo in skin biopsy specimens. Methods: Study involved 49 patients with psoriasis, 53 patients with vitiligo and 45 healthy control subjects. The clinical sign and PASI scores of psoriasis patients as well as the duration, and involved body area of vitiligo patients were recorded. Immunohistochemically, expression of IL22-R1 was investigated in the skin lesions of psoriasis and vitiligo patients and control group skin. Results: A statistically significant increase of the expression of IL22R1 was found in the skin biopsies of psoriasis patients compared with the vitiligo patients and control group subjects. In patients with psoriasis, there was a positive correlation between the expressions of IL-22R1 and PASI scores (p = 0.001, r = +0.572). In addition, there was no significant difference in epidermal IL-22R expression between vitiligo and the control group ( P=0.509). Conclusions: The present study has demonstrated that IL22-R1 doesn’t have a significant role in pathogenesis of the vitiligo and that Th22 cells may not be the pivotal cells in the pathophysiology of this disease. 

01 апреля 2015
Kocuria rosea: An emerging pathogen in acute bacterial meningitis- Case report
Kocuria rosea: An emerging pathogen i...Science and Natureorthography

Kocuria species is now increasingly being recognized as an emerging human pathogen most commonly associated with the use of medical devices in immunocompromised hosts or patients with severe underlying disease. Newer automated identification method such as Vitek 2 and 16S RNA based genotypic assay have greatly contributed to its recent recognition as a human pathogen. Here, we report a case of acute bacterial meningitis caused by Kocuria rosea in an otherwise healthy woman in a tertiary care neuropsychiatry setting.  

01 апреля 2015

Objective: To carry out a study on Acinetobacter isolates from various clinical samples in a tertiary care hospital in India. To evaluate the preva¬lence of A. baumannii isolates, their antibiograms and clinical significance. Their contribution as causative agents of nosocomial infections has also been evaluated. Methods: The clinical specimens over a period of 12 months from January 2013 to December 2013 were analyzed and the A. baumannii isolates obtained were further studied. Their antibiograms were studied and a clinical correlation was made to assess their pathogenic status. Results: A. baumannii was isolated in 417 samples out of 2116 gram negative isolates (19.7% prevalence) from the entire hospital. Maximum isolates were from exudates & abscesses (41.5%) followed by respiratory secretions (28%). Overall resistance of A .baumannii towards carbapenems was 25.65% from all hospital isolates. ICU isolates showed higher resistance (62.6%) as compared to Inpatient Department (35.5%) and Out-patient Department (1.86%). Conclusions: In this study, A. baumannii isolates showed pathogenic potential, however a majority were found to be carbapenem sensitive. There was significant correlation between the carbapenem resistant strains isolated from the intensive care units, in-patient and out-patient departments of the hospital.  

05 июня 2015

SAEED REZA JAMALI MOGHADAM, YOSOF MOJTAHEDI, SEYEDAHMAD SEYEDALINAGHI, REZVAN KAKAVAND GHALEH-NOEI, ABMS A 68-year-old female was hospitalized with a primary complaint of dyspnea in Ziaeian Hospital affiliated to Tehran University of Medical Sciences in April 2014. She had malaise and non-productive cough along with a loss of appetite during the last two days. She was also suffering slight tachypenea. The patient had normal chest x-ray and Computed Tomography (CT) scan on the admission time. Initially there was no response to the first empiric treatment, the scan was repeated after 2 days and subsequently we observed abnormal signs in the scan suggestive to pneumonia. KEY WORDS: Pneumonia Diagnosis Chest X-Ray CT scan Treatment 

03 октября 2015

MAXWELL KELVIN BILLAH, DOUGLAS KWANG, CHRISTIAN ADOFO, MICHAEL ADETOKUNBO OLU-TAIWO, GEORGE ANTEPIM PESEWU JMAA Objective: In the search for potent antimicrobial agents against bacteria and other microbial infections this study evaluated the antibacterial properties of millipedes extracts against selected control strains of bacterial pathogens including Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae. Methods: Two species of millipedes were identified as Ophistreptus guineensis S. (Diplopoda: Spirostreptidae) and Pachybolus ligulatus V. (Diplopoda: Pachybolidae) were collected from the University of Ghana Botanical Gardens and placed into 3 groups - Group 1 = O. guineensis alone, Group 2 = P. ligulatus alone, and Group 3 = mixture of O. guineensis + P. ligulatus. The millipedes were killed, dried, and grounded into coarse powders. Chloroform, ethanol, aqueous extracts were prepared and screened for activity using agar well and paper-disc diffusion assays. Minimum inhibitory and bactericidal concentrations (MIC and MBC) of the most active extracts were also evaluated by the broth micro-dilution technique. Results: Ethanol extracts of Group 3 (mixture of O. guineensis + P. ligulatus) showed the highest activity, with mean diameters of zones of inhibition of 29 ± 0.02 and 14 ± 0.00 mm against S. aureus and E. coli respectively. No activity was observed for Group 2 extracts (P. ligulatus alone), while some level of activities were observed for Group 1 extracts (O. guineensis alone). MIC and MBC values of 4.9 and 25.0 mg/ml of the ethanol extract of Group 3 were found against S. aureus. Conclusions: Work is in progress to isolate the bioactive agent(s) in millipede extracts. KEY WORDS: Antibacterial Extract Millipedes MIC MBC  

03 октября 2015