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Anti-hairloss and Hair growth promoter

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Hair growth cycle
Anti-hairloss and
Hair growth promoter
2
Hair cycle of head hair shaft
Stage of the hair cycle
В‰ Anagen : the growing phase
В‰ Catagen: the intermediate phase
В‰ Telogen : the shedding phase
Hair growth cycle
Exp. Gerontol. 2002;37:981-90.
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Causes of hair loss
Hair Loss
В„
Hair follicle gradually terminated
В‰ Terminal hair changes to vellus hair
Vellus hair : Terminal hair = 6-8 : 1 Normal
Vellus hair : Terminal hair = 0.1-3.9 : 1 Bald
В‰
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Nattaya Lourith, Ph.D.
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Reduction in hair follicle function due to
male hormones
Reduction in metabolic functions of hair
follicles and hair bulbs
Reduction in scalp physiological functions
Local impairment of circulation due to
tension in the scalp
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1
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Physical stress
Emotional stress
Diet considerations
Hormonal causes
Endocrinopathy
Oral medications:
Hair Loss
Overall causes
В„ Androgen
В„ Genetic
В„ Age
Blood thinning agents
Retinoids
В‰ Antihypertensive agents
В‰ Miscellaneous
В‰
Androgenic alopecia
В‰
Testosterone
5О±-Dihydrotestosterone
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Semin. Cutan. Med. Surg. 1998;17:276-283.
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Semin. Cutan. Med. Surg. 1998;17:276-283.
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A. Regional scalp
hair density scale
B. Regional scalp
zones
F : Frontal
M : Mid
T : Temporal
V : Vertex
Regions of scalp potentially involved in pattern hair loss
J. Am. Acad. Dermatol. 2001;45(suppl):S70-80.
Nattaya Lourith, Ph.D.
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J. Am. Acad. Dermatol. 2003;48:253-62.
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2
Hair loss patterns in male
Male Pattern
(Hamilton/Norwood)
J. Am. Acad. Dermatol.
1985;13:185-92.
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Graduation of hair loss in Ludwig pattern
J. Am. Acad. Dermatol. 2003;48:253-62.
Diffuse
Frontal Accentuation
(Ludwig)
(Olsen)
Hair loss patterns in female
J. Am. Acad. Dermatol. 2003;48:253-62.
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Graduation of hair loss in frontal accentuation pattern
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J. Am. Acad. Dermatol. 2003;48:253-62.
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Big head? Bald head?
Savin patterns of hair loss
Med. Hypo. 2009; 72: 23-28.
J. Am. Acad. Dermatol. 1999;40:106-9.
Nattaya Lourith, Ph.D.
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Basic ingredient and function
Hair care products
В„
Hair
В„ Hair
В„ Hair
В„ Hair
В„ Hair
В„
cleansing products
growth promoters
grooming cosmetics
waving and straightening products
coloring products
В„
В„
В„
В„
Detergent : removes dirt, styling products, sebum
and skin scale from hair and scalp
Foaming agent: allows shampoo to foam
Conditioner : soften and smoothen hair after
sebum removal
Thickener : thicken shampoo
Opacifier : makes shampoo opaque
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Basic shampoo categories
Basic ingredient and function
В„
В„
В„
В„
В„
В„
Sequestering agent : prevent soap scum from
forming on hair and scalp in hard water
В„
В„
pH adjusters or neutralizer : minimize hair
damage from base
Fragrance : give acceptable smell
В„
В„
В„
Preservative : prevent microbial and fungal
contaminations
В„
Specialty additive : treatment ingredient or
marketing aid to impart other benefit to shampoo
В„
В„
В„
В„
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Active ingredients : Hair loss
В„
В„
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В„
В„
Active ingredients : Hair loss
Finasteride : 5О±-reductase Type II inhibitor
Minoxidil : vasodilator (long lasting anagen)
Dutasteride or GI198745 : 5О±-reductase inhibitor
Iamin or prezatide copper : 5О±-reductase inhibitor
Folligen or copper chloride : 5О±-reductase inhibitor
Zinc : hair growth, 5О±-reductase Type I inhibitor
Polysorbate 80 : hair growing improvement
В„
В„
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В„
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Normal hair shampoo
Dry hair shampoo
Damaged hair shampoo
Oily hair shampoo
Everyday shampoo
Deep cleaning shampoo
Baby shampoo
Medicated shampoo
Conditioning shampoo
Hair dyeing shampoo
Ethnic shampoo
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MK-386 or ОІ-dimethyl-4-aza-5-cholestan-3one: 5О±-reductase inhibitor
WO9704002 : 5О±-reductase inhibitor
FCE28260 : 5О±-reductase inhibitor
FCE26073 or Turosteride : 5О±-reductase
Type II inhibitor
Ketoconazole : Androgenetic blocker
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Active ingredients : Hair loss
В„
В„
В„
В„
В„
В„
В„
В„
В„
Active ingredients : Hair loss
Canrenone 2%
Spironolactone 3%
Dexamethasone
Prednisone
Cyclosporin A
Cyproterone acetate
Flutamide
Drospirenone
Bromocriptine
В„
В„
В„
В„
В„
В„
В„
Amino acids : hair growth and healthy, 5О±reductase inhibitor
Biotin : hair nutrient and hair growth
Folic acid : hair nutrient and hair growth
Procyanidin B3 : hair thickener
Azelaic acid : strong DHT inhibitor
Ferritin
B7, B12
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Active ingredients : Hair loss
В„
Isoflavone
В„
В„
В„
В‰
В„
В„
В„
В„
Daizein
Genistein
Glycitein
В„
Essential fatty acid
В‰
Lignans
В„
В„
5О±-reductase inhibitor
Hair regrowth promoter
Phytoestrogens
В‰
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Enterodiol
Enterlactone
В‰
Bisnapthaquinone
Capsaicin
(-)-epoglaaocatechin-3-gallate
Soymethide-4
В‰
В‰
В„
Оі-linolenic acid, О±-linolenic acid, palmitoleic
acid, oleic acid, myristoleic acid
palmitic acid, stearic acid, oleic acid, linoleic
acid
Evening primrose oil
Emu oil
ОІ-sitosterol
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Pygeum : Pygeum africanum
Saw palmetto : Serenoa repens
- DHT formation inhibitor
- Androgenic blocker
- 5О±-reductase inhibitor
- 5О±-reductase inhibitor
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Chillies
- Capsaicin
Holy basil : Ocimum sanctum
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False daisy: Eclipta alba
Fenugreek : Trigonella foenum
- Multivitamin B
- Hair root strengthen
- DHT formation inhibitor
- Hair growth promoter
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False daisy: Eclipta alba
Treatment
Folicle count
1% minoxidil
2% minoxidil
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Fennel : Foeniculum vulgare
Skin thickness, Ојm
Anagen induction, %
69 В± 3.9
160.2 В± 10
87.5
73 В± 8.2
253.25 В± 6.6
87.5
1.6 mg E.alba
39 В± 8.4
417.4 В± 35.9
50
3.2 mg E.alba
66 В± 7.3
480.4 В± 41.2
87.5
- Antiinflammatory
- Androgenic blocker
- 5О±-reductase inhibitor
J. Ethanopharmacol. 2009. doi:10.1016/j.jep.2009.05.023
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Bayberry : Myrica rubra
Nettle : Urtica dioica
- 5О±-reductase inhibitor
- Hair growth stimulant
- Anti hair loss
- Androgenic blocker
- DHT blocker
- 5О±-reductase inhibitor
- Blood circulator
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Arborvitae : Thuja
Arborvitae : Thuja
- 5О±-reductase
Type II inhibitor
- sebum reduction
Compounds
5О±-reductase Type II inhibitor, IC50
Linoleic acid
31.55 Ојg/ml (112.50 ОјM)
Оі-Linolenic acid
5.55 Ојg/ml (19.93 ОјM)
T. occidentalis
2.6 Ојg/ml
Finasteride
0.34 ОјM
J. Dermatol. Sci. 2003; 31: 91-98.
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Avocado : Persea americana
Gourds
- 5О±-reductase Type I inhibitor
- Sebum secretion reduction
- Antidandruff
- Antiitching
- 5О±-reductase inhibitor
- Anti hair loss
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Burdock : Arctium lappa
Hop : Humulus lupulus
- 5О±-reductase inhibitor
- Hair growth stimulant
- Scalp tonics
- Scalp tonics
- Antidandruff
- Antiitching
- Anti hair loss
- Hair sheening
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Grape seeds
Pumpkin
- proanthocyanidins
- in vitro hair follicle proliferation promotion
- in vivo Telogen converts to Anagen
- 5О±-reductase inhibitor
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Willow
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Black cohosh : Cimicifuga racemosa
- Antiinflammatory
- 5О±-reductase inhibitor
- Hair loss treatment
- 5О±-reductase inhibitor
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Soy bean
Ginkgo : Ginkgo biloba
Flax seed
- Hair regrowth promoter
- Astringent
- Epidermis growth stimulant
- Antiinflammatory
- Radical scavenger
- 5О±-reductase inhibitor
- Grey hair treatment
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Tea : Camellia sinensis
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Sophora : Sophora flavescens
- Antioxidant
- Androgenic blocker
-5О±-reductase inhibitor
- 5О±-reductase Type II
inhibitor
-Similar activity with
saw palmetto
- Anagen elongation
activity
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Breadfruit: Artocarpus incisus
Licorice : Glycyrrhiza glabra
- DHT formation inhibitor
- Hair loss treatment
5О±-reductase Type II inhibitor
- Chlorophorin IC50 37 ОјM
- Artocarpin IC50 85 ОјM
Melanin biosynthesis inhibition
Planta Medica 2000; 66: 16-19.
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Henna : Lawsonia inermis Linn.
Aloe : Aloe vera L.
Hair growth accelerator
Leaf extracts have mild
antiinflammatory and antiallergic action
and analgesic effect
- Traditionally for hair loss
- Improve hair growth
following alopecia
Impart dark red shades :
Lawsone
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Rhinacanthus nasutus Kurz.
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Butterfly pea : Clitoria ternatea
- Hair loss treatment
- Grey hair treatment
- Antiinflammatory
- Antioxidant
- Hair growth promoter
- Grey hair recover
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Citrus grandis
Citrus hystrix DC.
Skin & scalp tonic
Exfoliation refresh
- Wound healing
- Antidandruff
- Soft & smooth hair
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Sapindus rarak A. DC.
Acacia concinna DC.
Wound healing
- Cleansing
- Shining
- Antidandruff
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Centella asiatica (L.) Urb.
Sesame : Sesamum indicum Linn.
Antioxidant
Wound healing
Blood circulation
Scalp conditioning
Energy stimulant
Detergent
Anti hair loss
- Skin & scalp soother
- Antioxidant
- Natural moisturizer
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Coconut : Cocos nucifera Linn.
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Cymbopogon citratus Stapf
- Oily and grease hair treatment
- Antidandruff
- Antiseptic
- Saturated fatty acid
- Lauric acid
- Myristic acid
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Garlic : Allium sativum L.
Ginger : Zingiber officinale Roscoe
- Dandruff control
- Antiseptic
- Tonic
- Antioxidant
- Antiinflammatory
- Antibacterial
- Antifungal
- Antiinflammatory
- Blood circulation stimulant
- Muscle relaxation
- Hair loss treatment
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Rice: Oryza sativa
Ginseng : Panax ginseng
- Skin & scalp conditioning
- Moisturizer
- Emollient
- Antioxidant
- Skin & scalp soften
- Aniinflammaroty
- Blood circulation
- Cell regeneration
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Almond: Prunus amygdalus
Sage : Salvia officinalis L.
- Skin conditioning
- Moisturizer
- Sun protect
- Hair conditioning
- Maintain the sheen of dark curly hair
- Strengthen and stimulate hair growth
- Antidandruff
- Anti hair loss
- Greasy hair treatment
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Rosemary : Rosmarinus officinalis Linn.
- Stimulate hair growth
- Antioxidant
- Greasy hair conditioner
- Gives body and sheen to hair
- Daily antidandruff treatment
Thyme :Thymus vulgaris L.
- Inhibit dandruff
- A scalp rub to prevent hair falling out
- Promote natural hair health
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Swertia japonica Makino
74
English Walnut Juglans regia L.
- Eczema
- Acne
- Hair loss
- Scalp itching
- Scalp peeling
- Dandruff
- abdominal pain
- skin infection
- blood circulation
- hair growth stimulant
- Emollient
- Skin disorder treatment: crack, abrasion, frostbite, chaps
- Sun burn treatment
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- Nappy rashes
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Propolis
Honey
- Antifungal
- Antibacterial
- Similar activity with aloe
- Hair growth promoter
- Skin & scalp conditioning
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Nattaya Lourith, Ph.D.
Black walnut : Juglan nigra
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Plants
Parts
Alpinia galanga
Leaves
5О±-reductase inhibitory activity, %
0
Tamarindus indica
Leaves
0
Albizia myriophylla
Leaves
5
Acacia concinna
Fruits
21
Flagellaria indica
Leaves
23
Leucaena leucocephala
Leaves
25
Citrus hystrix
Fruit peels
25
Clitoria ternatea
Flowers
29
Eucalyptus sp.
Leaves
47
Passiflora foetida
Fruits
47
Piper betle
Leaves
51
Mitragyna hirsuta
Leaves
53
Artocarpus altilis
Leaves
75
Ixora maerothyra
Leaves
79
Citrus hystrix
Fruit juices
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J. Wood Sci. 2000; 46: 385-389
Hair loss treatment example products
Provillus
Conc. 200 Ојg/ml
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Hair loss treatment example products
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Hair loss treatment example products
- Kigelia africana
- Niacin
- Biotin
- Plant Phytosterols
- Saw Palmetto Berry
- Macadameia Nut oil
- Borage Oil
- Evening Primrose oil
- Pygeum africana
- Green tea extract
- Salvia sclarea
- Gingko biloba
- Cinnamomum zeylanicum
- Panax ginseng
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Hair loss treatment example products
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Hair loss treatment example products
- Linolenic acid
- Linoleic Acid
- Oleic Acid
- Azaleic acid
- Vitamin B6
- Zinc
- Saw Palmetto Extract
- ОІ-Sitosterol
- Procyanidin Oligomers
Minoxidil 5% w/v for men
Minoxidil 2% for women
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Nattaya Lourith, Ph.D.
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Hair loss treatment example products
Hair loss treatment example products
- Hops extract
- Rosemary extract
- Swertia extract
- Saw palmetto
- zinc
- nettles
- pumpkin seed extract
- Si compounds
- Panthenol
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Hair loss treatment example products
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Hair loss treatment example products
- Soy bean
- Panax ginseng
- Castanea sativa
- Swertia extract
- Arinca montana
- Hedera helix
- Geranium maculatum
- Inositol, Panthenol
- Cystine, Cysteine, Methionine
- Biotin
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Hair loss treatment example products
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Hair loss treatment example products
- Biotin
- Zinc PCA
- Panax ginseng, Ginkgo biloba, Swertia
japonica, Palmaria palmata, Soy bean germ,
Glycyrrhiza glabra extracts
- Simmondsia chinensis Oil,
- Benzyl Nicotinate, Inositol, L-Cystine,
Cysteine, Choline, Niacin, Methionine
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Nattaya Lourith, Ph.D.
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Hair growth promoters evaluations
Hair growth promoters evaluations
Animals Mice
В„ hair length
В„ hair growth area
Rabbits
В„ hair length and weight
Hamsters
В„ sebaceous glands size (in vivo)
В„ 5О±-reductase inhibition (in vitro)
В„ DHT receptor inhibition (in vitro)
Monkeys
В„ hair growth at head
Humans
В„
В„
В„
В„
В„
Tissue culture
В„
В„
photographic evaluation
trichogram method
5О±-reductase inhibition
hair wash test
blood flow measurement
hair roots culture
hair root cells culture
91
Hair growth promoters evaluations : Mice
92
Biometrological Test
Hair Loss / Hair Growth
Principle
- Anti-hair loss efficacy
- Anti-hair regrowth products
- Videomicroscope visualizations
Protocol design
- Long term studies: M0-M1-M2
- Up to M0-M3-M6 studies
- Female and male volunteers
- No age criteria
VideotrichogramВ®
30 days application of Asiasari radix extract 1% solution in 40% EtOH
Illustrations :
J. Dermsci. 2005; 38:89-97.
93
Selected references
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Lee OS, Kang HH, Han SH. 1997. Oriental herbs in cosmetics. Cosmet
Toiletries 112:57-64.
Kameyama S. 1995. Application and consideration of medicinal plants for
hair care products. Frag J 23:28-34.
Takahashi T, Kamiya T, Yokoo Y. 1998. Proanthocyanidins from grape
seeds promote proliferation of mouse hair follicle cells in vitro and convert
hair cycle in vivo. Acta Derm Venerol 78:428-432.
Kim SH, Jeong KS, Ryu SY, Kim TH. 1998. Panax ginseng prevents apoptosis
in hair follicles and accelerates recovery of hair medullary cells in
irradiated mice. In vivo 12:219-222.
Camacho-MartГ­nez FM. 2009. Hair loss in women. Semi. Cutan. Med. Surg.
28:19-32.
Yonenaga M. 2001. Henna leaf extracts and makeup materials containing
henna. Jpn Kokai Tokkyo Koho Patent JP2001335496.
Bruneton J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants.
Lavoisier Publishing: Paris.
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Nattaya Lourith, Ph.D.
the telogenous hairs
D0
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D2
Thank you for your attention
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