¶·È‰È·ÙÚÈ΋ B√ƒ∂ÿ√À ∂§§Õ¢√˜, 13: 176 - 178, 2001
¶∂ƒπ°ƒ∞º∏ ¶EPI¶Tø™H™
∫·Ïo‹ı˘ ·Úo‰È΋ ˘ÂÚʈÛÊ·Ù·Û·ÈÌ›·
Û ÎoÚ›ÙÛÈ ËÏÈΛ·˜ 3 ¯ÚfiÓˆÓ
Ã. ¡·Ó¿˜, °. Δ˙o˘‚ÂϤ΢, ¢. ∫·ÙÚÈo‡
μã ¶·È‰È·ÙÚÈ΋ ∫ÏÈÓÈ΋ ∞.¶.£., ¡oÛoÎoÌ›o ∞Ã∂¶∞
¶ÂÚ›ÏË„Ë. ¶ÂÚÈÁÚ¿ÊÂÙ·È ÂÚ›ÙˆÛË Î·Ïo‹ıo˘˜ ·Úo‰È΋˜ ˘ÂÚʈÛÊ·Ù·Û·ÈÌ›·˜ Û ÎoÚ›ÙÛÈ ËÏÈΛ·˜ 3 ¯ÚfiÓˆÓ. ∏ ‰È¿ÁÓˆÛË Ù¤ıËΠÌÂÙ¿ ·fi Ù˘¯·›o ÂÚÁ·ÛÙËÚÈ·Îfi ¤ÏÂÁ¯o o˘ ¤ÁÈÓ ÛÙ· Ï·›ÛÈ· ‰ÈÂÚ‡ÓËÛ˘ oÛÙÈÎÒÓ
·ÏÁÒÓ ÛÙ· οو ¿ÎÚ·. ∏ ÙÈÌ‹ Ù˘ ·ÏηÏÈ΋˜ ʈÛÊ·Ù¿Û˘ Ùo˘ oÚo‡ ¤Êı·Û ÛÙȘ 4900 u/L Î·È Â·Ó‹Ïı ÛÂ
Ê˘ÛÈoÏoÁÈο Â›‰· ÌÂÙ¿ ·fi 4 Ì‹Ó˜ ¯ˆÚ›˜ η̛· ·Ú¤Ì‚·ÛË.
§¤ÍÂȘ-ÎÏÂȉȿ: ·ÏηÏÈ΋ ʈÛÊ·Ù¿ÛË, ˘ÂÚʈÛÊ·Ù·Û·ÈÌ›·, ·Úo‰È΋ ·‡ÍËÛË Ù˘ ·ÏηÏÈ΋˜ ʈÛÊ·Ù¿Û˘
Nanas Chr, Tzoubelekeis G, Catriu D. Benign transient hyperphosphatasaemia in a 3 years old girl.
B′ Pediatric Dept Aristotelion University, AHEPA Hospital, Thessaloniki, Paediatr N Gr 2001, 13: 176 - 178.
A case of benign transient hyperphosphatasaemia , which was found in a 3 year old girl with transient bone
pain, is described. The diagnosis was suggested by the finding of increased serum alkaline phosphatase
activity more than eightfold the upper reference limit (4.900 u/L) without evidence of bone or liver disease
and by its subsequent return to normal levels within approximately 4 months after diagnosis. The etiology
of the condition and possible mechanisms of the enzyme increase are discussed.
Key words: alkaline phosphatase, hyperphosphatasaemia, transient elevation of alkaline phosphatase
Ì ÙoÓ ŒÏÏËÓ· ·È‰›·ÙÚo ÛÙËÓ ‡·ÚÍË Ù˘ ÓoÛoÏoÁÈ΋˜ ·˘Ù‹˜ oÓÙfiÙËÙ·˜, Ë oo›· oÏϤ˜ ÊoÚ¤˜
·Ó¢ڛÛÎÂÙ·È ÛÙ· Ï·›ÛÈ· Ù˘¯·›o˘ ÂÚÁ·ÛÙËÚÈ·Îo‡
ÂϤÁ¯o˘.
∂ÈÛ·ÁˆÁ‹
∏ ηÏo‹ı˘ ·Úo‰È΋ ˘ÂÚʈÛÊ·Ù·Û·ÈÌ›·
(∫¶À) Â›Ó·È Ì›· ÓoÛoÏoÁÈ΋ oÓÙfiÙËÙ· ·ÁÓÒÛÙo˘
·ÈÙÈoÏoÁ›·˜ o˘ ÁÈ· ÚÒÙË ÊoÚ¿ ÂÚÈÁÚ¿ÊËÎÂ
ÚÈÓ ·fi oÏÏ¿ ¯ÚfiÓÈ· ·fi ÙoÓ Bach1. ∂ÎÙoÙ ηÈ
̤¯ÚÈ Û‹ÌÂÚ· ¤¯o˘Ó ·Ó·ÊÂÚı› ÌÂÌoӈ̤Ó˜ ÂÚÈÙÒÛÂȘ ÛÙË ‰ÈÂıÓ‹ ‚È‚ÏÈoÁÚ·Ê›·2,3. ∏ ηٿÛÙ·ÛË ·˘Ù‹ ·Ú·ÙËÚÂ›Ù·È Î·Ù¿ ÙËÓ ‚ÚÂÊÈ΋ Î·È ÓËȷ΋ ËÏÈΛ· Î·È ˘o¯ˆÚ› Û˘Ó‹ıˆ˜ ̤۷ Û 3-6
Ì‹Ó˜. ∏ ·ÈÙÈo·ıoÁ¤ÓÂÈ· ·Ú·Ì¤ÓÂÈ ¿ÁÓˆÛÙË, Èı·ÓoÏoÁÂ›Ù·È fï˜ fiÙÈ Û¯ÂÙ›˙ÂÙ·È Ì ÚoËÁËı›۷
Ïo›ÌˆÍË, ηٿ ηÓfiÓ· ÈoÁÂÓo‡˜ ·ÈÙÈoÏoÁ›·˜4. §fiÁˆ Ù˘ Û·ÓÈfiÙËÙ·˜ Ù˘ ÓfiÛo˘, ÂÚÈÁÚ¿Êo˘Ì ÙËÓ
·Ú·¿Óˆ ÂÚ›ÙˆÛË ÁÈ· Ó· ¢·ÈÛıËÙooÈ‹Ûo˘-
¶ÂÚÈÁÚ·Ê‹ ÂÚ›ÙˆÛ˘
∫oÚ›ÙÛÈ ËÏÈΛ·˜ 3 ¯ÚfiÓˆÓ ÚoÛÎoÌ›ÛıËÎÂ
ÛÙËÓ ∫ÏÈÓÈ΋ Ì·˜ ÁÈ· ·Ú·ÎoÏo‡ıËÛË ‰ÈfiÙÈ ·Úo˘Û›·˙ ·Úo‰Èο oÛÙÈο ¿ÏÁË ÛÙ· οو ¿ÎÚ·
Î·È oχ ·˘ÍË̤ÓË ÙÈÌ‹ ·ÏηÏÈ΋˜ ʈÛÊ·Ù¿Û˘
Ùo˘ oÚo‡. ∂›Ó·È Ùo ‰Â‡ÙÂÚo ·È‰› Ê·ÈÓoÙ˘Èο ˘ÁÈÒÓ ÁoÓ¤ˆÓ Ì ÂχıÂÚo oÈÎoÁÂÓÂÈ·Îfi Î·È ·ÙoÌÈÎfi
ÈÛÙoÚÈÎfi. OÈ ÁoÓ›˜ Ùo˘ ·È‰Èo‡ ·Ó¤ÊÂÚ·Ó fiÙÈ Ì›·
‚‰oÌ¿‰· ÚÈÓ ·Úo˘Û›·Û ˘ÚÂÙfi Ì ηٷÚÚo˚-
176
¶·È‰È·ÙÚÈ΋ B√ƒ∂ÿ√À ∂§§Õ¢√˜, 13, 2
ο Ê·ÈÓfiÌÂÓ· Î·È ÛÙË Û˘Ó¤¯ÂÈ· ·Úo‰Èο oÛÙÈο
¿ÏÁË ÛÙ· οو ¿ÎÚ·. Δo ·È‰› ˘o‚Ï‹ıËΠ۠ıÂÚ·›· ÌfiÓo Ì ·ÓÙÈ˘ÚÂÙÈο Î·È ÛÙË Û˘Ó¤¯ÂÈ·
ÂÂÛΤÊıËÛ·Ó ·È‰›·ÙÚo o oo›o˜ Û˘Ó¤ÛÙËÛ ÂÚÁ·ÛÙËÚÈ·Îfi ¤ÏÂÁ¯o fio˘ ‰È·ÈÛÙÒıËΠoχ ·˘ÍË̤ÓË ÙÈÌ‹ ·ÏηÏÈ΋˜ ʈÛÊ·Ù¿Û˘ oÚo‡ 4348u/L
(Ê.Ù. ÁÈ· ÙËÓ ËÏÈΛ· Ùo˘ 150-670 u/L), ÂÓÒ Ùo Ca ηÈ
o ƒ Ùo˘ oÚo‡, oÈ ÙÚ·ÓÛ·ÌÈÓ¿Û˜, Ù· Ï¢ÎÒÌ·Ù· ηÈ
Ë Á-GT ‹Ù·Ó ÂÓÙfi˜ ÙˆÓ Ê˘ÛÈoÏoÁÈÎÒÓ oÚ›ˆÓ.
∞fi ÙËÓ ·ÓÙÈÎÂÈÌÂÓÈ΋ ÂͤٷÛË ‰ÂÓ ‰È·ÈÛÙÒıËΠٛoÙ Ùo ·ıoÏoÁÈÎfi .O Ï‹Ú˘ ÂÚÁ·ÛÙËÚÈ·Îo˜ ¤ÏÂÁ¯o˜ (¶›Ó. 1) ‰ÂÓ ·oÎ¿Ï˘„ oÛÙÈ΋, Ë·ÙÈ΋ ‹ ¿ÏÏË ÓfiÛo, o˘ Ó· ‰ÈηÈoÏoÁ› ÙËÓ oχ ·˘ÍË̤ÓË ÙÈÌ‹ Ù˘ ·ÏηÏÈ΋˜ ʈÛÊ·Ù¿Û˘ (ÂÚÈÛÛfiÙÂÚo ·fi Ùo oÎÙ·Ï¿ÛÈo ÙˆÓ ·ÓˆÙ¤ÚˆÓ oÚ›ˆÓ ÁÈ·
ÙËÓ ËÏÈΛ· Ùo˘ ·È‰Èo‡). ∏ ·ÎÙÈÓoÁÚ·Ê›· Ù˘ ‰ÂÍÈ¿˜ ˯ÂoηÚÈ΋˜ ¿ÚıÚˆÛ˘ ηıÒ˜ Î·È oÈ ·ÎÙÈÓoÁڷʛ˜ Ì·ÎÚÒÓ oÛÙÒÓ ÙˆÓ Î¿Ùˆ ¿ÎÚˆÓ ‰ÂÓ ·ÂÎ¿Ï˘„·Ó Â˘Ú‹Ì·Ù· ÂÓ‰ÂÈÎÙÈο Ú·¯›Ùȉ·˜ ‹ ¿ÏÏ˘
oÛÙÈ΋˜ ÓfiÛo˘. ∏ ÙÈÌ‹ Ù˘ ·ÏηÏÈ΋˜ ʈÛÊ·Ù¿Û˘
Ùo˘ oÚo‡ ÙˆÓ ÁoÓ¤ˆÓ ‹Ù·Ó ÂÓÙfi˜ ÙˆÓ Ê˘ÛÈoÏoÁȶ›Ó·Î·˜ 1. ∂ÚÁ·ÛÙËÚÈ·Îfi˜ ¤ÏÂÁ¯o˜
ñ Hb 11,6g/dl, Ht 35,7%
ñ §Â˘Î¿ ·ÈÌoÛÊ·›ÚÈ· 7000 mm3 (¶oÏ˘ 48%, §ÂÌÊo
52%)
ñ Δ∫∂ 14 mm 1Ë ÒÚ·, CRP ·ÚÓËÙÈ΋, o˘Ú›· 31,5
mg/dl (ÊÙ 10-50mg/dl)
ñ ∫Ú·ÙÈÓ›ÓË oÚo‡ 0,75mg/dl (ÊÙ 0,6-1,1mg/dl)
ñ ΔÚ·ÓÛ·ÌÈÓ¿Û˜: SGOT 15,6U/L (Ê.Ù<50U/L),
SGPT 44,6U/L (Ê.Ù.<50U/L)
ñ ÁGT 13,6U/L (Ê.Ù.<40U/L)
ñ ∞ÏηÏÈ΋ ʈÛÊ·Ù¿ÛË oÚo‡ 4600 U/L (Ê.Ù. 150670U/L)
ñ Ca 9,2mg/dl (Ê.Ù. 8-10.5mg/dl), P oÚo‡ 5mg/dl
(Ê.Ù. 3-6mg/dl)
ñ Fe oÚo‡ 68Ìg/dl (Ê.Ù. 60-120Ìg/dl), ºÂÚÚÈÙ›ÓË
15,6ng/ml (90-200 ng/ml)
ñ °·Ï·ÎÙÈ΋ ‰Â¸‰ÚoÁÂÓ¿ÛË 374 U/L (Ê.Ù. 200-400
U/L)
ñ OÏÈ΋ ¯oÏÂÚ˘ıÚ›ÓË 0,966 mg/dl (Ê.Ù. ̤¯ÚÈ 1,5
mg/dl)
ñ ŒÌÌÂÛo˜ ¯oÏÂÚ˘ıÚ›ÓË 0,680mg/dl (Ê.Ù. ̤¯ÚÈ 1,5
mg/dl)
ñ ÕÌÂÛo˜ ¯oÏÂÚ˘ıÚ›ÓË 0,286mg/dl (Ê.Ù. 0,2-0,3
mg/dl)
ñ OÏÈο Ï¢ÎÒÌ·Ù· 7,88g/dl (Ê.Ù. 6-8g/dl)
ñ §Â˘ÎˆÌ·Ù›Ó˜ 4,12g/dl (Ê.Ù. 4-6g/dl), ÛÊ·ÈÚ›Ó˜
3,76g/dl (Ê.Ù. 2-4g/dl)
ñ ¶·Ú·ıoÚÌfiÓË 12,5pg/ml (Ê.Ù. 10-59pg/ml)
ñ Ca o‡ÚˆÓ 24h 72mg/dl (Ê.Ù. 5-40mg/dl)
ñ P o‡ÚˆÓ 24h 129,3mg/dl (Ê.Ù. 0,3-130mg/dl)
177
ÎÒÓ oÚ›ˆÓ (ÌËÙ¤Ú· 110 u/L, ·Ù¤Ú·˜ 120 u/L).
™Â Ó¤· ̤ÙÚËÛË Ù˘ ·ÏηÏÈ΋˜ ʈÛÊ·Ù¿Û˘,
Ì›· ‚‰oÌ¿‰· ·ÚÁfiÙÂÚ·, Ë ÙÈÌ‹ Ù˘ ‚Ú¤ıËΠÛÂ
˘„ËÏfiÙÂÚ· Â›‰· (4900 u/L), ÂÓÒ ÌÂÙ¿ ·fi ‰‡o
Ì‹Ó˜ Ë ÙÈÌ‹ Ù˘ ·ÏηÏÈ΋˜ ʈÛÊ·Ù¿Û˘ ‹Ù·Ó 740
u/L Î·È Ù¤ÛÛÂÚȘ Ì‹Ó˜ ·ÚÁfiÙÂÚ· Ë ÙÈÌ‹ Ù˘ Â·Ó‹Ïı ÛÂ Ê˘ÛÈoÏoÁÈο Â›‰· ÁÈ· ÙËÓ ËÏÈΛ· Ùo˘
·È‰Èo‡ (400 u/L).
Δ· ·Ú·¿Óˆ ÎÏÈÓÈο Î·È Î˘Ú›ˆ˜ Ù· ÂÚÁ·ÛÙËÚȷο Â˘Ú‹Ì·Ù·, Ë ÚoËÁËı›۷ ÈoÁÂÓ‹˜ Ïo›ÌˆÍË
ηıÒ˜ Î·È Ë Ê˘ÛÈoÏoÁÈ΋ ÙÈÌ‹ Ù˘ ·ÏηÏÈ΋˜ ʈÛÊ·Ù¿Û˘ ÙˆÓ ÁoÓ¤ˆÓ ¤ıÂÛ·Ó ÙË ‰È¿ÁÓˆÛË Ù˘
∫¶À.
™˘˙‹ÙËÛË
∏ ηÏo‹ı˘ ·Úo‰È΋ ˘ÂÚʈÛÊ·Ù·Û·ÈÌ›·
Â›Ó·È ÌÈ· ÓoÛoÏoÁÈ΋ oÓÙfiÙËÙ· Ë oo›· oÏϤ˜ ÊoÚ¤˜ ‰È·Ê‡ÁÂÈ Ù˘ ‰È¿ÁÓˆÛ˘ ηıÒ˜ ÚfiÎÂÈÙ·È ÂÚ› ·Û˘Ìو̷ÙÈ΋˜ ηٿÛÙ·Û˘, Î·È o ÚoÛ‰ÈoÚÈÛÌfi˜ Ù˘ ·ÏηÏÈ΋˜ ʈÛÊ·Ù¿Û˘ Ùo˘ oÚo‡ ‰ÂÓ Û˘ÓËı›˙ÂÙ·È Ó· ÂÚÈÏ·Ì‚¿ÓÂÙ·È ÛÙȘ ÂÚÁ·ÛÙËÚȷΤ˜
ÂÍÂÙ¿ÛÂȘ Úo˘Ù›Ó·˜ ÛÙ· ‚Ú¤ÊË Î·È ÌÈÎÚ¿ ·È‰È¿. ∏
ÓoÛoÏoÁÈ΋ ·˘Ù‹ oÓÙfiÙËÙ· Â›Ó·È ¤Ó· ηÏfiËı˜ ·Úo‰ÈÎfi Ê·ÈÓfiÌÂÓo, o˘ ·Ú·ÙËÚÂ›Ù·È Û ‚Ú¤ÊË
Î·È Ó‹È· ËÏÈΛ·˜ ¤ˆ˜ 5 ¯ÚfiÓˆÓ, ÂÍ›Ûo˘ Î·È ÛÙ·
‰‡o ʇϷ, ¯ˆÚ›˜ ÙËÓ ·Úo˘Û›· Ë·ÙÈ΋˜ ‹ oÛÙÈ΋˜
ÓfiÛo˘1,4. ∏ ·ÏηÏÈ΋ ʈÛÊ·Ù¿ÛË Â·Ó¤Ú¯ÂÙ·È
ÛÙ· Ê˘ÛÈoÏoÁÈο Â›‰· Û ‰È¿ÛÙËÌ· 3 ¤ˆ˜ 6 ÌËÓÒÓ fiˆ˜ Û˘Ó¤‚Ë Î·È ÛÙË ‰È΋ Ì·˜ ÂÚ›ÙˆÛË.
∏ ·ÈÙÈoÏoÁ›· Ù˘ ∫¶À ·Ú·Ì¤ÓÂÈ ·‰È¢ÎÚ›ÓÈÛÙË. ¶Èı·ÓoÏoÁÂ›Ù·È fiÙÈ Â›Ó·È ·oÙ¤ÏÂÛÌ· ÚoËÁËı›Û˘ Ïo›ÌˆÍ˘, ηٿ ηÓfiÓ· ÈoÁÂÓo‡˜, fiˆ˜ ·Ó·Ê¤ÚÂÙ·È ÛÙË ‰ÈÂıÓ‹ ‚È‚ÏÈoÁÚ·Ê›·5,6. £ÂˆÚÂ›Ù·È fiÙÈ
o ˘‡ı˘Óo˜ ÏoÈÌoÁfiÓo˜ ·Ú¿ÁoÓÙ·˜ ÂËÚ¿˙ÂÈ Èı·Ófiٷٷ ÙËÓ ·Ú·ÁˆÁ‹, ÙË ÛÙ·ıÂÚfiÙËÙ· ‹ ÙËÓ Î¿ı·ÚÛË Ù˘ ·ÏηÏÈ΋˜ ʈÛÊ·Ù¿Û˘ ·fi ÙËÓ Î˘ÎÏoÊoÚ›· Î·È ¤ÙÛÈ Ë ÙÈÌ‹ Ù˘ ·˘Í¿ÓÂÈ Û Â›‰· ÂÓÙ·Ï¿ÛÈ· ‹ Î·È ÌÂÁ·Ï‡ÙÂÚ· ÙˆÓ ·ÓˆÙ¤Úˆ Ê˘ÛÈoÏoÁÈÎÒÓ ÙÈÌÒÓ ÁÈ· Ù· ‚Ú¤ÊË Î·È Ó‹È·. ™ÙË ‰È΋ Ì·˜ ÂÚ›ÙˆÛË, ηıÒ˜ ·Ó·Ê¤Úo˘Ó oÈ ÁoÓ›˜ Ùo˘ ·È‰Èo‡,
ÚoËÁ‹ıËΠ̛· ‚‰oÌ¿‰· ÚÈÓ ÙËÓ ÂÚÁ·ÛÙËÚȷ΋
ÂͤٷÛË Ù˘ ·ÏηÏÈ΋˜ ʈÛÊ·Ù¿Û˘, Èı·Ó‹ ÈoÁÂÓ‹˜ Ïo›ÌˆÍË ‰È¿ÚÎÂÈ·˜ 3-4 ËÌÂÚÒÓ.
∏ ·o˘Û›· ÈÎÙ¤Úo˘, oÈ Ê˘ÛÈoÏoÁÈΤ˜ ÙÈ̤˜ ÙˆÓ
ÙÚ·ÓÛ·ÌÈÓ·ÛÒÓ, Ù˘ Á-GT Î·È ÙˆÓ ÏÂ˘ÎˆÌ¿ÙˆÓ Ùo˘
oÚo‡ Û˘ÓËÁoÚo‡Ó ˘¤Ú Ùo˘ ·oÎÏÂÈÛÌo‡ Ë·ÙÈ΋˜
ÓfiÛo˘. ¶¤Ú·Ó fï˜ ÙˆÓ ÓoÛËÌ¿ÙˆÓ Ùo˘ ‹·Ùo˜ ηÈ
ÙˆÓ oÛÙÒÓ Ë ‰È·ÊoÚÈ΋ ‰È¿ÁÓˆÛË Ù˘ ∫¶À Ú¤ÂÈ
Ó· ÂÚÈÏ·Ì‚¿ÓÂÈ Î·È ÙËÓ oÈÎoÁÂÓ‹ ηÏo‹ıË ˘ÂÚʈÛÊ·Ù·Û·ÈÌ›· Ë oo›· ÎÏËÚoÓoÌÂ›Ù·È Ì ÙoÓ ·˘-
178
¶·È‰È·ÙÚÈ΋ B√ƒ∂ÿ√À ∂§§Õ¢√˜, 13, 2
ÙoÛˆÌÈÎfi ÂÈÎÚ·Ùo‡ÓÙ· ¯·Ú·ÎÙ‹Ú·, ÂÈ̤ÓÂÈ ÁÈ·
oÏÏ¿ ¯ÚfiÓÈ· Î·È ‰ÂÓ ˘o¯ˆÚ› ̤۷ Û ‰È¿ÛÙËÌ·
oÏ›ÁˆÓ ÌËÓÒÓ7. ∞ÏψÛÙ ÛÙË ‰È΋ Ì·˜ ÂÚ›ÙˆÛË o
¤ÏÂÁ¯o˜ ÙˆÓ ÁoÓ¤ˆÓ ·¤‚Ë ·ÚÓËÙÈÎfi˜.
∞fi Ù· ·Ú·¿Óˆ Ê·›ÓÂÙ·È fiÙÈ Ë ÂÚ›ÙˆÛ‹
Ì·˜ ·oÙÂÏ› ¯·Ú·ÎÙËÚÈÛÙÈÎfi ·Ú¿‰ÂÈÁÌ· ·Úo‰È΋˜ ηÏo‹ıo˘˜ ˘ÂÚʈÛÊ·Ù·Û·ÈÌ›·˜ ‰ÈfiÙÈ ÏËÚ› Ù· ‰È·ÁÓˆÛÙÈο ÎÚÈÙ‹ÚÈ·2,8 (¶›Ó. 2), Ù˘ ∫¶À
Ù· oo›· oÈ ·È‰›·ÙÚoÈ Ú¤ÂÈ Ó· ¤¯o˘Ó ˘fi„Ë
Ùo˘˜ ÁÈ· ÙËÓ oÚı‹ ‰È¿ÁÓˆÛË Ù˘ ÓoÛoÏoÁÈ΋˜ ·˘Ù‹˜ oÓÙfiÙËÙ·˜.
¶›Ó·Î·˜ 2. ¢È·ÁÓˆÛÙÈο ÎÚÈÙ‹ÚÈ· ÙÂÎÌËÚ›ˆÛ˘ ηÏo‹ıo˘˜ ·Úo‰È΋˜ ˘ÂÚʈÛÊ·Ù·Û·ÈÌ›·˜
1. ∏ÏÈΛ· <5 ¯ÚfiÓˆÓ
2. ∞o˘Û›· ÂÌÊ·ÓÒÓ ÎÏÈÓÈÎÒÓ Û˘ÌÙˆÌ¿ÙˆÓ ‹ ÛËÌ›ˆÓ ÂÓ‰ÂÈÎÙÈÎÒÓ Ë·ÙÈ΋˜ ‹ oÛÙÈ΋˜ ÓfiÛo˘
3. ∫ÏÈÓÈ΋ ÂͤٷÛË ·ÚÓËÙÈ΋ ÁÈ· oÛÙÈ΋ ‹ Ë·ÙÈ΋
ÓfiÛo
4. ¶·Ú·ÎÏÈÓÈÎfi˜ ¤ÏÂÁ¯o˜ ÁÈ· oÛÙÈ΋ ‹ Ë·ÙÈ΋ ÓfiÛo
·ÚÓËÙÈÎfi˜
5. ∏ÏÂÎÙÚoÊfiÚËÛË Ù˘ ·ÏηÏÈ΋˜ ʈÛÊ·Ù¿Û˘
(·‡ÍËÛË ÙˆÓ Ë·ÙÈÎÒÓ ÈÛoÂÓ˙‡ÌˆÓ)
6. ∂¿Óo‰o˜ ÙˆÓ ÂÈ¤‰ˆÓ Ù˘ ·ÏηÏÈ΋˜ ʈÛÊ·Ù¿Û˘ ÛÂ Ê˘ÛÈoÏoÁÈο ÁÈ· ÙËÓ ËÏÈΛ· Ùo˘ ·È‰Èo‡
Â›‰·, ÂÓÙfi˜ ÙÚÈÒÓ ¤ˆ˜ ¤ÍÈ ÌËÓÒÓ
Kraut J.R et al. 1985
μÈ‚ÏÈÔÁÚ·Ê›·
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Z. Kinderheilk 1954, 74: 593-603.
2. Kraut JR, Metrick M, Maxwell NR, Kaplan MM. Isoenzyme
in Transient Hyperphosphatasemia of infancy. Arch J
Dis Child 1985, 139: 736-740.
3. Stein P, Rosalki SB, Ying AF and Hjelm M. Transient Hyperphosphatasemia of infancy and Early Childhood;
Clinical and biochemical features of 21 cases and Literature Review. Clin Chem 1987, 33: 313-318.
4. Schonau E, Herzog KH, Bohles HJ. Transient hyperphosphatasaemia of infancy. Eur J Pediatr 1988, 148: 264266.
5. Crofron PM. What is the cause of benign transient hyperphosphatasaemia? A study of 35 cases. Clin Chem 1988,
34: 335-340.
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transient hyperphosphatasaemia. Eur J Pediatr 1985,
143: 323-324.
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Acta paediatr Scand 1980, 69: 235-238.
8. Kruse K, Kurz N. Further evidence for infectious origin of
isolated transient hyperphosphatasaeia. Eur J Pediatr
1989, 148: 453-454.
∞ÏÏËÏoÁÚ·Ê›·:
¡·Ó¿˜ ÃÚ‹ÛÙo˜
™Ù. ∫˘ÚȷΛ‰Ë 1
546 36 £ÂÛÛ·ÏoÓ›ÎË
Corresponding author:
Chr. Nanas
1 St. Kyriakidi Str.
Thessaloniki 546 36

Διαβάστε ολόκληρο το άρθρο - Παιδιατρική Βορείου Ελλάδος

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