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Dangerous Liaisons: translating cancer biology into better patients

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Dangerous
Liaisons
translating cancer biology
into better patients management
56th Annual Meeting of the
Italian Cancer Society
Ferrara, 11-13 September 2014
Università degli Studi di Ferrara
56
th
Annual Meeting of the
Italian Cancer Society
Dangerous
Liaisons
translating cancer biology
into better patients management
CONGRESS VENUE
Università degli Studi di Ferrara - Via Luigi Borsari, 46 - 44121 Ferrara
OPENING CEREMONY VENUE
Azienda Ospedaliero Universitaria di Ferrara
Arcispedale Sant’Anna - Via Aldo Moro, 8 - 44124 Cona – Ferrara
SIC SECRETARIAT
Società Italiana di Cancerologia
Via G. Venezian, 1 - 20133 Milan, Italy
Phone +39 02 2666895 - Fax +39 02 2664342
E-mail: [email protected]
www.cancerologia.it
ORGANIZING SECRETARIAT
C.S.C. S.r.l.
Via L.S. Gualtieri, 11 - 06123 Perugia
Tel+390755730617 - Fax +390755730619
www.csccongressi.it
2
With the auspices of
COMUNE
DI FERRARA
Città Patrimonio
dell’Umanità
3
56th
Dangerous
Liaisons
translating cancer biology
into better patients management
Committee
SIC SCIENTIFIC BOARD
President
Silvia Giordano (Candiolo Cancer Institute - FPO, IRCCS, University of Turin, Candiolo, Italy)
President Elect
Gabriella Sozzi (IRCCS National Cancer Institute, Milan, Italy)
Board
Rita Falcioni (Regina Elena National Cancer Institute, Rome, Italy)
Davide Melisi (University of Verona, Italy)
Nicola Normanno (National Cancer Institute “G. Pascale”, Naples, Italy)
Massimo Santoro (“Federico II” University, Naples, Italy)
Elda Tagliabue (IRCCS National Cancer Institute, Milan, Italy)
Giulia Taraboletti (“Mario Negri” Institute for Pharmacological Research, Bergamo, Italy)
Giuseppe Viglietto (University of Magna Græcia, Catanzaro, Italy)
Members under 35
Marco Macagno (University of Turin, Italy)
Selena Ventura (Orthopaedic Rizzoli Institute, Bologna, Italy)
Past President
Riccardo Dolcetti (CRO-IRCCS, National Cancer Institute, Aviano, Pordenone, Italy)
SCIENTIFIC AND ORGANIZING COMMITTEE
Scientific Coordinator
Massimo Negrini (University of Ferrara, Italy)
Local Scientific Committee
Silvano Capitani, (University of Ferrara, Italy)
Giorgio Cavallesco, (University Hospital of Ferrara, Italy)
Antonio Cuneo, (University Hospital of Ferrara, Italy)
Francesco Di Virgilio, (University of Ferrara, Italy)
Antonio Frassoldati, (University Hospital of Ferrara)
Giovanni Lanza, (University Hospital of Ferrara, Italy)
Alberto Liboni, (University Hospital of Ferrara, Italy)
Paolo Pinton, (University of Ferrara, Italy)
Silvia Sabbioni, (University of Ferrara, Italy)
Mauro Tognon, (University of Ferrara, Italy)
Stefano Volinia, (University of Ferrara, Italy)
4
Faculty
Reuven Agami
Cancer Institute - Amsterdam, The Netherlands
Mattia Boeri
IRCCS National Cancer Institute - Milan, Italy
James Brenton
Cancer Research UK Cambridge Institute - University of Cambridge, UK
George Adrian Calin MD Anderson Cancer Center - University of Texas, Houston, Texas, USA
Silvano Capitani University of Ferrara, Italy
Carlo M. Croce
Ohio State University - Columbus, Ohio, USA
Ruggero De Maria
Regina Elena National Cancer Institute - Rome, Italy
Pier Paolo Di Fiore
IFOM-IEO Campus - Milan, Italy
Francesco Di Virgilio University of Ferrara, Italy
Janine Erler
BRIC-Biotech Research & Innovation Centre - University of Copenhagen, Denmark
Rita Falcioni Regina Elena National Cancer Institute - Rome, Italy
Brunangelo Falini
University of Perugia, Italy
Antonio Frassoldati University Hospital of Ferrara
Gaia Cristina Ghedini IRCCS National Cancer Institute - Milan, Italy
Christopher Heeschen Spanish National Cancer Research (CNIO) - Madrid, Spain
Enrico Iaccino University Magna Graecia - Catanzaro, Italy
Marilena Iorio IRCCS National Cancer Institute - Milan, Italy
Simon Joosse
University Medical Center- Hamburg, Eppendorf , Germany
Guido Kroemer
INSERM, Institut Gustave Roussy - Villejuif, France
Marco Macagno University of Turin, Italy
Valerie Matarese
UpTo infotechnologies - Vidor, Italy
Alberto Mantovani
University of Milan, Italy
Davide Melisi University of Verona, Italy
Andrea Morandi University of Florence, Italy
Massimo Negrini University of Ferrara, Italy
Clara Nervi
University La Sapienza - Rome, Italy
Nicola Normanno
National Cancer Institute “G. Pascale” - Naples, Italy
Pier Paolo Pandolfi Beth Israel Deaconess Medical Center - Boston, Massachussets, USA
Pier Giuseppe Pelicci IFOM-IEO Campus - Milan, Italy
Paolo Pinton University of Ferrara, Italy
Ymera Pignochino Institute for Cancer Research and Treatment - Candiolo, Turin, Italy
Vito Pistoia
Gaslini Children’s Hospital - Genoa, Italy
Valeria Poli
University of Turin, Italy
Sabina Sangaletti
IRCCS National Cancer Institute - Milan, Italy
Gabriella Sozzi IRCCS National Cancer Institute - Milan, Italy
Elda Tagliabue IRCCS National Cancer Institute - Milan, Italy
Giulia Taraboletti “Mario Negri” Institute for Pharmacological Research - Bergamo, Italy
Giampaolo Tortora
University of Verona, Italy
Giuseppe Viglietto University of Magna Græcia - Catanzaro, Italy
Selena Ventura Orthopaedic Rizzoli Institute - Bologna, Italy
Stefano Volinia University of Ferrara, Italy
5
Programme at a glance
Thursday September 11th - AULA MAGNA - OSPEDALE CONA
10.00 - 13.00
Pre-Meeting SIC young investigators
14.00 - 14.30
Welcome Opening
14.30 - 15.15
Opening Lecture
15.15 - 18.30
Session 1: Cancer Microenvironment and Inflammation
19.00 - 19.15
Bus Transfer
19.15 - 22.00
Welcome Cocktail
Friday September 12th - POLO CHIMICO BIO MEDICO (Mammut)
08.00
Registration and poster hanging
08.30 - 10.30
Session 2: Non Coding RNAs and Epigenetics
10.30 - 11.00
Coffee Break
11.00 - 13.00
Poster Viewing with Authors
13.00 - 14.00
Light Lunch
14.00 - 15.30
Poster Discussion (4 parallel sessions)
15.30 - 16.45
Session 3a: Cancer Stem Cells
16.45 - 17.15
Coffee Break
17.15 - 18.00
Session 3b: Cancer Stem Cells
18.15 - 19.15
SIC General Assembly
20.15
Social Dinner
Saturday September 13th - POLO CHIMICO BIO MEDICO (Mammut)
08.30 - 09.15
Plenary Lecture
09.15 - 11.30
Session 4: “Translational” Therapy
11.30 - 12.30
Award Ceremony
12.30 - 13.30
Light Lunch
13.30 - 14.15
Giorgio Prodi Lecture
14.15 - 15.45
Session 5: Translational Diagnostics: NGS, Circulating Cells\Nucleic Acids
15.45 - 16.30
Closing Lecture
16.30 - 17.00
Closing Remarks
6
Thursday September 11th
Scientific Programme
Venue: AULA MAGNA - OSPEDALE CONA
10.00 - 13.00
PRE-MEETING SIC YOUNG INVESTIGATORS
Chairs: Marco Macagno (Turin, Italy), Selena Ventura (Bologna, Italy)
“Writing Grant Proposals: three techniques to present your idea with clarity and
conviction”
Valerie Matarese Ph.D. (Vidor, TV)
Meeting of SIC young investigators
14.00 - 14.30 WELCOME OPENING
14.30 - 15.15 OPENING LECTURE
Causes and Consequences of microRNA Dysregulation in Cancer
Carlo M. Croce (Columbus, Ohio, USA)
15.15 - 18.30 Session 1: CANCER MICROENVIRONMENT AND INFLAMMATION
Chairs: Francesco Di Virgilio (Ferrara, Italy), Andrea Morandi (Florence, Italy)
Immunosuppressive microenvironnment in neuroblastoma
Vito Pistoia (Genoa, Italy)
New players and targets in tumor vasculature
Ugo Cavallaro (IEO, Istituto Europeo di Oncologia, Milan, Italy), Elena Magrini, Fabrizio
Bianchi, Andrea Doni, Francesca Angiolini, Alessandra Villa, Massimiliano Mazzone
The transcritpion factor STAT3 at the crossroad between cancer and inflammation
Valeria Poli (Turin, Italy)
Stable modulation of the glycolytic phenotype of tumor cells by anti-VEGF therapy
Stefano Indraccolo (Istituto Oncologico Veneto, IRCCS, Padua, Italy), Matteo Curtarello,
Elisabetta Zulato, Giorgia Nardo, Silvia Valtorta, Giulia Guzzo, Elisabetta Rossi, Giovanni
Esposito, Aichi Msaki, Andrea Rasola, Luca Persano, Francesco Ciccarese, Roberta
Bertorelle, Sergio Todde, Mario Plebani, Henrike Schroer, Stefan Walenta, Wolfgang MuellerKlieser, Alberto Amadori, Rosa Maria Moresco
The extracellular matrix at the interface between immunity
and cancer
Sabina Sangaletti (Milan, Italy)
Matrix remodelling during cancer progression
Janine Erler (Copenhagen, Denmark)
15.15 - 15.45 15.45 - 16.00 V9
16.00 - 16.30
16.30 - 16.45 V 17
16.45 - 17.15
17.15 - 17.45
17.45 - 18.30
PLENARY LECTURE
Molecular pathways linking inflammation and cancer
Alberto Mantovani (Milan, Italy)
19.00 - 19.15 19.15 - 22.00 BUS TRANSFER
Welcome Cocktail
7
Friday September 12th
Scientific Programme
Venue: POLO CHIMICO BIO MEDICO (Mammut)
08.00
REGISTRATION AND POSTER HANGING
08.30 - 10.30 Session 2: NON CODING RNAS AND EPIGENETICS
Chairs: Massimo Negrini (Ferrara, Italy), Stefano Volinia (Ferrara, Italy)
08.30 - 09.00 About Noam Chomsky, DNA patterns, Non-codingRNAs and Cancer patients
George A. Calin (Houston, Texas, USA)
09.00 - 09.15 Targeting aberrant HDAC4 activity in multiple myeloma (MM) through a miR-29bbased therapeutic strategy
Nicola Amodio (Department of Experimental and Clinical Medicine, University Magna Graecia
R2
of Catanzaro, Catanzaro, Italy), Marzia Leotta, Eugenio Morelli, Maria Angelica Stamato,
Lavinia Raimondi, Anna Maria Gullà, Maria Teresa Di Martino, Teresa Calimeri, Marco Rossi,
Antonino Neri, Pierosandro Tagliaferri, Pierfrancesco Tassone
09.15 - 09.45 EnhancerRNAs at the service of p53
Reuven Agami (Amsterdam, The Netherlands)
09.45 - 10.00 Mir-660 is downregulated in lung cancer patients and its replacement inhibits
lung tumorigenesis by targeting MDM2-p53 interaction
Orazio Fortunato (Fondazione IRCCS Istituto Nazionale dei Tumori, Tumor Genomics Unit,
R9
Milan), Mattia Boeri, Massimo Moro, Carla Verri, Mavis Mensah, Davide Conte, Luca Roz,
Ugo Pastorino, Gabriella Sozzi
10.00 - 10.30 The epigenetic role of microRNA-223 in hematopoiesis and leukemias
Clara Nervi (Roma, Italy)
8
10.30 - 11.00 Coffee Break
11.00 - 13.00 13.00 - 14.00 POSTER VIEWING WITH AUTHORS
Light Lunch
Friday September 12th
Scientific Programme
Venue: POLO CHIMICO BIO MEDICO (Mammut)
14.00 - 15.30 14.00 - 15.30
POSTER DISCUSSION (4 PARALLEL SESSIONS)
Poster Discussion 1
Room E2
CANCER GENETICS, EPIGENETICS AND CONTROL OF GENE EXPRESSION
Chairs: Marilena Iorio (Milan, Italy), Giuseppe Viglietto (Catanzaro, Italy)
B 18
Searching for Oncogenic Drivers in the Stepwise Process of Hepatocarcinogenesis
Patrizia Zavattari (Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy),
Andrea Perra, Marta Anna Kovalik, Maria Maddalena Angioni, Silvia Menegon, Annalisa
Petrelli, Luca Quagliata, Giovanna Maria Ledda-Columbano, Luigi Terracciano, Silvia
Giordano, Amedeo Columbano
B8
Involvement of ALK in Pediatric Rhabdomyosarcoma
Patrizia Gasparini (Experimental Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori,
Hospital, Milan, Italy), Raffaella Villa, Michela Casanova, Paola Collini, Rita Alaggio, Roberto
Caserini, Monica Tortoreto, Nadia Zaffaroni, Cristina Meazza, Maria Grazia Daidone, Maura
Massimino, Andrea Ferrari, Gabriella Sozzi
B 14
Whole Exome Sequencing revealed a novel PALB2 mutation in a male breast
cancer family
Valentina Silvestri(Department of Molecular Medicine, Sapienza University of Rome, Rome,
Italy), Piera Rizzolo, Anna Sara Navazio, Virginia Valentini, Veronica Zelli, Giovanni Chillemi,
Marco Montagna, Laura Ottini
C2
Impairment of V-ATPase as a therapeutic modality targeting cancer stem cells of
rhabdomyosarcoma
Sofia Avnet (Orthopaedic Pathophysiology and Regenerative Medicine, Istituto Ortopedico
Rizzoli, Bologna, Italy), Manuela Salerno, Shigekuni Hosogi, Nicola Baldini
C 13
Hedgehog-Gli signaling pathway in lung cancer stem cells and its drug mediated
targeting
Agnese Po (Dipartimento di Medicina Molecolare, Sapienza Università di Roma, Roma, Italy),
Marianna Silvano, Danilo Cucchi, Adriana Eramo, Evelina Miele, Valentina Salvati, Giovanni
Sette, Ruggero De Maria, Ann Zeuner, Enrico De Smaele, Alberto Gulino, Elisabetta Ferretti
R5
miRNA and gene regulatory pathway of stage I epithelial ovarian cancer:
reconstructing cancer circuits
Enrica Calura (Department of Biology, University of Padova, Padua, Italy), Gabriele Sales, Paolo
Martini, Robert Fruscio, Eliana Bignotti, Antonella Ravaggi, Lara Paracchini, Mariacristina
Di Marino, Laura Zanotti, Dionyssios Katsaros, Germana Tognon, Enrico Sartori, Sergio
Pecorelli, Maurizio D’Incalci, Sergio Marchini, Chiara Romualdi
R 12
Regulation of microRNA processing by mutp53 in colon cancer
Francesca Garibaldi (IFO-Istituti Fisioterapici Ospitalieri, Istituto Nazionale dei tumori Regina
Elena, Rome, Italy), Emmanuela Falcone, Gianluca Bossi, Daniela Trisciuoglio, Giulia Piaggio,
Aymone Gurtner
9
Friday September 12th
Scientific Programme
Venue: POLO CHIMICO BIO MEDICO (Mammut)
14.00 - 15.30
Poster Discussion 2
MICROENVIRONMENT AND TUMOR IMMUNOLOGY
Chairs: Enrico Iaccino (Catanzaro, Italy), Giulia Taraboletti (Bergamo, Italy)
D4
An Angiopoietin-like Protein 2 autocrine signaling promotes EMT during
pancreatic ductal carcinogenesis
Carmine Carbone (Digestive Molecular Clinical Oncology Research Unit, Università degli
Studi di Verona, Verona, Italy), Geny Piro, Matteo Fassan, Anna Tamburrino, Maria Mihaela
Mina, Marco Zanotto, Paul J Chiao, Claudio Bassi, Aldo Scarpa, Giampaolo Tortora, Davide
Melisi
D5
Endothelial podosome rosettes regulate vascular branching in tumor angiogenesis
Giulia Chiaverina (Institute for Cancer Research and Treatment, Department of Oncology,
University of Torino, Turin, Italy, Candiolo, Italy), Giorgio Seano, Paolo Armando Gagliardi,
Laura di Blasio, Alberto Puliafito, Roberto Sessa, Claire Bouvard, Guido Tarone, Dominique
Helley, Lydia Sorokin, Guido Serini, Federico Bussolino, Luca Primo
D 15
Cadherin 6 and thyroid cancer: beyond a structural function
Valentina Sancisi (Laboratory of Translational Research, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy), Greta Gandolfi, Moira Ragazzi, Ione Tamagnini, Simonetta Piana,
Alessia Ciarrocchi
F7
Metabolic control of YAP and TAZ by the mevalonate pathway
Giovanni Sorrentino (Laboratorio Nazionale CIB, Università degli studi di Trieste, Trieste, Italy),
Naomi Ruggeri, Valeria Specchia, Michelangelo Cordenonsi, Miguel Mano, Sirio Dupont,
Andrea Manfrin, Eleonora Ingallina, Roberta Sommaggio, Silvano Piazza, Antonio Rosato,
Stefano Piccolo, Giannino Del Sal
V1
The multifaceted anti-tumor activity of interleukin-27 in human lung cancer
Irma Airoldi (Laboratory of Oncology, Istituto Giannina Gaslini, Genoa, Italy), Silvia Esposito,
Maria Grazia Tupone, Giulia Barbarito, Marco Vincenzo Russo, Serena Di Meo, Carlo
Sorrentino, Emma Di Carlo
V 26
Mast Cell-Derived IL-8 Induces Epithelial-to-Mesenchymal Transition and Stem
Cell Features in Human Thyroid Cancer cells
Carla Visciano (Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Istituto per
L’Endocrinologia e l’Oncologia Molecolare del CNR, University of Naples, Federico II, Naples,
Italy), Federica Liotti, Nella Prevete, Gaetano Calì, Renato Franco, Francesca Collina, Amato
de Paulis, Gianni Marone, Massimo Santoro, Rosa Marina Melillo
U2
The complement system in the immunosurveillance of HER-2 positive mammary
cancer
Silvio Bandini (Molecular Biotechnology Center, University of Turin, Turin, Italy), Marco
Macagno, Albana Hisi, Laura Conti, Stefania Lanzardo, Amanda Bello, Manuela Iezzi,
Federica Cavallo
10
Room E3
Friday September 12th
Scientific Programme
Venue: POLO CHIMICO BIO MEDICO (Mammut)
14.00 - 15.30
Poster Discussion 3
BIOMARKERS AND THERAPY
Chairs: Ymera Pignochino (Turin, Italy), Selena Ventura (Bologna, Italy)
Room D6
L8
A specific c-MET inhibitor (JNJ-38877605) reduces bone metastases induced by
kidney cancer stem cells in a human-in-mice model
Ilaria Roato (CeRMS -Center for Research and Medical Studies- A.O. Città della Salute e della
Scienza di Torino, Turin, Italy), Livio Trusolino, Lucia D’Amico, Giorgia Migliardi, Roberta Pulito,
Timothy Perera, Paolo M. Comoglio, Riccardo Ferracini
L2
Establishment of a platform of patient-derived tumor xenografts (EOC-PDX) to
study the biology and therapy of epithelial ovarian cancer
Francesca Bizzaro (Department of Oncology, IRCCS-Istituto di Ricerche Farmacologiche
Mario Negri, Milan, Italy), Francesca Ricci, Marta Cesca, Federica Guffanti, Alessandra
Decio, Carmen Ghilardi, Patrizia Perego, Robert Fruscio, Paola Ostano, Giovanna Chiorino,
Maria Rosa Bani, Giovanna Damia, Raffaella Giavazzi
P 16
Evaluation by multicolor flow cytometry of circulating endothelial cells as
prognostic and predictive biomarker in healthy donors and colorectal cancer
patients
Alessandra Leone (Istituto Nazionale per lo Studio e la Cura dei Tumori, ‘Fondazione Giovanni
Pascale’- IRCCS – Italia, Naples, Italy), Maria Serena Roca, Carlo Vitagliano, Francesco
Bianco, Silvia De Franciscis, Gianluca Rotta, Ernesta Cavalcanti, Rosa Azzaro, Annamaria
Diodato, Carmela Cacciapuoti, Guglielmo Nasti, Antonio Avallone, Alfredo Budillon, Elena Di
Gennaro
P3
Activated d16HER2 homodimers and SRC kinase signaling axis is a predictor of
Trastuzumab benefit
Lorenzo Castagnoli (Fondazione IRCCS - Istituto Nazionale dei Tumori, Dept. Experimental
Oncology and Molecular Medicine, Milan, Italy), Manuela Iezzi, Valentina Ciravolo, Gaia
Cristina Ghedini, Tiziana Triulzi, Patrizia Gasparini, Roberta Zappasodi, Patrizia Nanni, Elda
Tagliabue, Serenella Pupa
P 25
Predictive biomarkers of trabectedin (TR) and PARP-1 inhibitor synergism in
preclinical models of mesenchymal tumors (MTs)
Ymera Pignochino (Candiolo Cancer Institute, IRCCS, University of Torino Medical School,
Candiolo, Turin, Italy), Federica Capozzi, Carmine Dell’Aglio, Marta Canta, Marco Basiricò,
Annalisa Lorenzato, Lorenzo D’ambrosio, Danilo Galizia, Maria Serena Benassi, Massimo
Aglietta, Giovanni Grignani
P 26
TAK1-regulated expression of BIRC3 is responsible for chemoradiotherapy (CRT)
resistance in esophagogastric junction (EGJ) adenocarcinoma
Geny Piro (Laboratory of Oncology and Molecular Therapy, University of Verona, Verona,
Italy), Simone Giacopuzzi, Maria Bencivenga, Giuseppe Verlato, Carmine Carbone, Valeria
Merz, Anna Tamburrino, Giovanni de Manzoni, Giampaolo Tortora, Davide Melisi
P9
Clinical relevance of circulating endothelial cells as prognostic and early
predictive biomarker of response to anti-angiogenic therapy in rectal cancer
patients
Elena Di Gennaro (Istituto Nazionale per lo Studio e la Cura dei Tumori, “Fondazione Giovanni
Pascale”- IRCCS – Italia, Naples, Italy), Paolo Delrio, Alessandra Leone, Tania Moccia,
Eleonora Cardone, Carmen Romano, Antonio Avallon, Alfredo Budillon
11
Friday September 12th
Scientific Programme
Venue: POLO CHIMICO BIO MEDICO (Mammut)
12
14.00 - 15.30
Poster Discussion 4
DRUG RESISTANCE, SIGNAL TRANSDUCTION, TARGETED THERAPY
Chairs: Gaia Cristina Ghedini (Milan, Italy), Marco Macagno (Turin, Italy)
Room D7
A3
GSK3A and GSK3B isoforms are redundant in modulating drug resistance and
chemotherapy-induced necroptosis of p53-null colon cancer cells
Marialuisa Lavitrano (Department of Surgery and Translational Medicine, University of Milan
- Bicocca, Milan, Italy), Emanuela Grassilli, Leonarda Ianzano, Fabio Pisano, Sara Bonomo,
Carola Missaglia, Laura Masiero, Maria Grazia Cerrito, Gabriele Romano, Serena Bonin,
Giorgio Stanta, Roberto Giovannoni
I1
CDK6 and platinum drug resistance in Epithelial Ovarian Cancer
Alessandra Dall’Acqua (CRO of Aviano, National Cancer Institute, Aviano, Italy), Monica
Schiappacassi, Maura Sonego, Ilenia Pellizzari, Gustavo Baldassarre
I8
GENE expression profiling of Human Melanoma cell lines and clinical samples
defines subsets differing in susceptibility to BRAFV600E and pathway-directed
inhibitors
Marialuisa Sensi (Fondazione IRCCS Istituto Nazionale dei Tumori, Hospital, Milan, Italy),
Matteo Dugo, Gabriella Nicolini, Gabrina Tragni, Ilaria Bersani, Antonella Tomassetti, Silvana
Canevari, Andrea Anichini
Q1
Multicomponent Nanovectors for Delivery of Therapeutic Molecules in Cancer
Armando Cevenini (CEINGE-Biotecnologie Avanzate, s.c.a r.l., Naples, Italy), Alessandro
Parodi, SM Khaled, Iman K Yazdi, Matteo Ciancaioni, Xueavu Liu, Christian Celia, Nicoletta
Peluso, Rosa Peltrini, Stefania Orrù, Luigi Del Vecchio, Ennio Tasciotti, Mauro Ferrari,
Francesco Salvatore
S4
Interaction between Sonic hedgehog and bombesin neuropeptide receptor
pathways in small cell lung carcinoma
Maria Domenica Castellone (Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio
Nazionale delle Ricerche, Naples, Italy), Mikko Olavi Laukkanen, Silvio Gutkind
S3
The Double-Stranded RNA Adenosine Deaminase, ADAR1, Represents a Novel
Substrate for AKT
William Blalock (Institute of Molecular Genetics-National Research Council of Italy (IGMCNR), Rizzoli Orthopedic Institute, Bologna, Italy), Mirco Raffini, Manuela Piazzi, Irene
Faenza, Alberto Bavelloni
T7
Effects of Hedgehog signaling inhibition on epithelial-stromal interactions in
triple negative breast cancer cells.
Concetta Di Mauro (Department of molecular medicine and surgery, University of Naples
Federico II, Naples, Italy), Roberta Rosa, Valentina D’Amato, Luigi Formisano, Roberta
Marciano, Lucia Raimondo, Alberto Servetto, Bianca Maria Veneziani, Sabino De Placido,
Roberto Bianco
Friday September 12th
Scientific Programme
Venue: POLO CHIMICO BIO MEDICO (Mammut)
15.30 - 16.45 Session 3a: CANCER STEM CELLS
Chairs: Silvano Capitani (Ferrara, Italy), Elda Tagliabue (Milan, Italy)
15.30 - 16.00 Towards new therapy based on Cancer Stem Cell Targeting
Ruggero De Maria (Rome, Italy)
16.00 - 16.15 Surgery-induced wound response promotes stem-like and tumor‑initiating
features of breast cancer cells via STAT3 signaling
C 18
Ilenia Segatto (CRO of Aviano, National Cancer Institute, Aviano, Italy), Stefania Berton,
Maura Sonego, Samuele Massarut, Tiziana Perin, Gustavo Baldassarre, Barbara Belletti
16.15 - 16.45 Dynamics of cancer stem cells in the pancreas
Christopher Heeschen (Madrid, Spain)
16.45 - 17.15 Coffee Break
17.15 - 18.00 Session 3b: CANCER STEM CELLS
Chairs: Paolo Pinton (Ferrara, Italy), Gabriella Sozzi (Milan, Italy)
Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast
Alessandro Zannini (Laboratorio Nazionale cib, Dipartimento Scienze della Vita - Università
degli Studi di Trieste, Trieste, Italy), Alessandra Rustighi, Elena Campaner, Giovanni
Sorrentino, Silvano Piazza, Giannino Del Sal
Connecting the machineries of tumor suppression and cell fate determination in
stem cells
Pier Paolo Di Fiore (Milan, Italy)
17.15 - 17.30
C 21
17.30 - 18.00
18.15 - 19.15 SIC General Assembly
20.15 Social Dinner
13
Saturday September 13th
Scientific Programme
Venue: POLO CHIMICO BIO MEDICO (Mammut)
08.30 - 09.15
Plenary Lecture
Restoration of anticancer immunosurveillance: a hallmark of successful antineoplastic therapies
Guido Kroemer (Villejuif, France)
09.15 - 11.30 09.15 - 09.45
09.45 - 10.15
Session 4: “TRANSLATIONAL” THERAPY
Chairs: Rita Falcioni (Rome, Italy), Antonio Frassoldati (Ferrara, Italy)
State of the art and perspectives for the development of targeted therapies
Giampaolo Tortora (Verona, Italy)
Genomics of Hairy Cell Leukemia: biological and clinical implication
Brunangelo Falini (Perugia, Italy)
10.15 - 10.45
Next generation personalized medicine in colon and lung cancer
Nicola Normanno (Naples, Italy) - Sponsored by EACR
10.45 - 11.30
11.15 - 11.30
Companies lectures
Chair: Massimo Negrini (Ferrara, Italy),
Unlocking cancer with multiomic approach: from sample to data analysis
Valentina Maran (Sales Channel Manager Genomics Italy Diagnostic
and Genomics Group, Agilent Technologies)
Droplet Digital PCR, new and enabling tool for cancer research
Alessandro Martino (Field Application Specialist Southern Europe Bio-Rad Laboratories S.r.l.
Life Science Group)
The latest news in NGS Cancer clinical research with Ion Torrent
Alberto Madini (Sales Rep., Life Sciences Solution, Thermo Fisher Scientific)
11.30 - 12.30 Award Ceremony
“Piero Trivella” and “EACR” Awards for the best posters
“Elena Cappannini” Award for the best 2013 publication
“Pezcoller Foundation” scholarship 2013-2014 winner award
Characterization of molecular mechanisms involved in MDSC mediated tolerance:
paving the way to overcome tumor attack
Samantha Solito (Department of Surgery, Oncology and Gastroenterology, University of Padua)
“Pezcoller Foudation” scholarship 2015-2016 award
Travel Grants
12.30 - 13.30 Light Lunch
10.45 - 11.00
11.00 - 11.15
14
Saturday September 13th
Scientific Programme
Venue: POLO CHIMICO BIO MEDICO (Mammut)
13.30 - 14.15 Giorgio Prodi Lecture
Regulation of Self Renewal in Cancer Stem Cells
Pier Giuseppe Pelicci (Milan, Italy)
14.15 - 15.45 Session 5: TRANSLATIONAL DIAGNOSTICS: NGS, CIRCULATING CELLS\NUCLEIC ACIDS
Chairs: Mattia Boeri (Milan, Italy), Davide Melisi (Verona, Italy)
Disseminated and circulating tumor cells as prognostic and predictive markers
Simon Joosse (Eppendorf, Germany)
A specific and sensitive method for the individuation of EGFR mutations in circulating free tumor DNA from NSCLC patients
Raffaella Pasquale (Istituto Nazionale Tumori “Fondazione G. Pascale”-IRCCS, Cell Biology
and Biotherapy Unit, Naples, Italy), Anna Maria Rachiglio, Claudia Esposito, Alessandra Sacco,
Riziero Esposito Abate, Simona Bevilacqua, Cristin Roma, Antonella De Luca, Nicola Normanno
Circulating tumour DNA as a biomarker of response in cancer therapy
James Brenton (Cambridge, UK)
Early relapse upon trastuzumab treatment is predictable by transcriptome analysis
of primary HER2-positive breast cancer
Tiziana Triulzi (Fondazione IRCCS Istituto Nazionale dei Tumori, Department of Experimental
Oncology and Molecular Medicine, Milan, Italy), Loris De Cecco, Aleix Prat, Marco Sandri, Marta
Giussani, Maria Luisa Carcangiu, Silvana Canevari, Serena Di Cosimo, Sylvie Menard, Manuela
Campiglio, Elda Tagliabue
14.15 - 14.45
14.45 - 15.00 P 20
15.00 - 15.30
15.30 - 15.45 P 29
15.45 - 16.30
Closing Lecture
Deconstructing the molecular genetics of human cancer and its therapeutic implications
Pier Paolo Pandolfi (Boston, Massachussets, USA)
16.30 - 17.00 Closing Remarks
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Scientific Information
CME CREDITS
No. 3,2 Italian Ministry of Health CME (Continuing Medical
Education) credits have been assigned for the following
Professions and Disciplines:
Profession: Medical Surgeon (Disciplines: Haematology,
Medical Genetics, Pathological Anatomy, Pharmacology
and Clinical Toxicology, Clinical Pathology, Internal Medicine);
Biologist, Pharmacist, Chemist (Discipline: Analytical Chemistry); Physicist (Discipline: Health Physics); Veterinary
Surgeon.
SLIDES
Slides must be in English. Computer videoprojection will
be available in Power Point. Please communicate to the
Organizing Secretariat your different requirements as
soon as possible. Slides have to be handed to the slide
centre one hour before the session beginning.
PRIZES
Saturday September 13th 2014
“Piero Trivella” and “EACR” Awards for the best
posters
“Elena Cappannini” Award for the best 2013 publication
“Pezcoller Foudation” Ferruccio and Elena Bernardi
scholarship Award
Travel Grants
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SIC SECRETARIAT
Società Italiana di Cancerologia
Via G. Venezian, 1 - 20133 Milan, Italy
Phone +39 02 2666895 - Fax +39 02 2664342
E-mail: [email protected] - www.cancerologia.it
ORGANIZING SECRETARIAT
C.S.C. S.r.l.
Via L.S. Gualtieri, 11 - 06123 Perugia
Tel+390755730617 - Fax +390755730619
www.csccongressi.it
General Information
DATES
Ferrara 11th -13th September 2014
CONGRESS VENUE
Università degli Studi di Ferrara - Via Luigi Borsari, 46 44121 Ferrara
OPENING CEREMONY VENUE
Azienda Ospedaliero Universitaria di Ferrara
Arcispedale Sant’Anna - Via Aldo Moro, 8 - 44124 Cona
– Ferrara
OFFICIAL LANGUAGE
English. Simultaneous translation will not be provided.
BADGE
Participants and exhibitors are kindly requested to wear
their badge during the congress.
CERTIFICATE OF ATTENDANCE
Certificate of attendance is given to all registered participants at the end of the congress.
EXHIBITION AND SPONSORSHIP
A technical, pharmaceutical and publication exhibition will
be held in the Congress Venue. For any information please
contact the Organizing Secretariat.
REGISTRATION FEE
SIC MEMBER
NON SIC MEMBER
SIC MEMBER UNDER 35
NON SIC MEMBER UNDER 35
On site
€ 420,00
€ 520,00
€ 260,00
€ 335,00
VAT 22% Included.
Registration Fee Includes: Admission to the scientific
sessions, admission to the exhibit area, congress kit, abstract book, attendance certificate, welcome cocktail, coffee-breaks, light lunches and social dinner.
Online registration available at www.csccongressi.it
PAYMENT
Payment online: by bank transfer or credit card data collection
Payment on site: by cash or credit card (accepted VISA and
MASTERCARD)
CANCELLATION
In case of cancellation no reimbursement is foreseen.
17
General Information
Congress Venue
ingressi
1: ingresso auto
(parcheggio interno non
a pagamento)
2: ingresso pedonale
3: ingresso auto
(parcheggio
area Sant’Anna
non a pagamento)
Altri parcheggi a
pagamento
a: Rampari San Rocco
b: Fossato di Mortara
Da stazione ferroviaria
TAXI (circa 10 eur)
Autobus n. 1
diretto a Rampari
San Rocco (1,50 eur)
Da Aeroporto Bologna
Navetta “Bus & Fly”
arriva in Stazione
Ferroviaria (15,00 eur)
HOW TO REACH THE CONGRESS VENUES
By Car
Motorway A13, exit Ferrara South Parking
area:
• Inside the “MAMMUT” (entrance 1)
• Inside the ex-hospital St. Anna (entrance 3)
• Along the Rampari of San Rocco or Fossato
di Mortara (toll parking - 2,00 Euros for the
entire day)
By train
Ferrara stop
From the station to the congress venue:
• by taxi
•bus N. 1 Rampari San Rocco stop, in front
of the MAMMUT
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By plane
From Bologna Marconi Airport to Ferrara
Shuttle “BUS & FLY” (Time: 60 minutes. Cost:
15,00 Euros). It stops in the city center and at
the train station.
Walking
From the city center 15 min walking distance
By bus
bus N. 1 Rampari San Rocco stop, in front of
the MAMMUT
General Information
Opening Day Venue
HOW TO REACH THE OPENING DAY VENUE
By Car
Motorway A13, exit Ferrara South
Then proceed straight for about 10 km on the
highway RA8 (Raccordo Ferrara-Mare) to the
exit Cona
Parking area: in the free parking lots of the
hospital
By bus
bus n. 6, starting at various bus stops in from
center city every 15 minutes. It stops right in
front of the Conference Hall
19
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