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2014 LEUKEMIA

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SECTION OF HEMATOLOGY
3rd International Conference
LEUKEMIA 2014
Santa Margherita Ligure - Portofino
May 21–24, 2014
Chairmen
Angelo M. Carella
Felicetto Ferrara
Enrica Morra
3rd International Conference
LEUKEMIA 2014
This Conference will be dedicated to Prof. John M. Goldman
PRESENTATION
The Conference, with the participation of the most important
International and Italian experts, wants to provide an update on the
most innovative aspects of cellular and molecular biology, treatment
of acute and chronic leukemias, myelodysplastic syndromes and
Ph-negative chronic myeloproliferative syndrome. One section will
be dedicated to the new drugs in onco-hematology.
ADDRESSED TO
Physicians specialized in Hematology, Oncology and Biologists.
OFFICIAL LANGUAGE
The meeting will be held in English. No simultaneous translation will
be provided.
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PROGRAMME
WEDNESDAY, MAY 21
CHALLENGES IN PHILADELPHIAPOSITIVE LEUKEMIAS
NEW DRUGS IN ONCO-HEMATOLOGY
(not for CME credits)
Chairmen: Robin Foà
Angelo M. Carella
Chairmen: Massimo Federico
Pier Luigi Zinzani
16.30
Introduction
Robin Foà
14.00
Celgene pipeline and in earlydevelopment programs
James Carmichael
16.35
Current clinical options in
Ph+ ALL
Robin Foà
14.15
Novelties in strategic approach
to chronic hematological
malignancies
Alf Bernhardt
16.50
Early and deep molecular
response predictive of long term
outcome in Ph+ leukemias
Giovanni Martinelli
14.30
An update of Brentuximab
Vedotin and its future prospective
Andreas Engert
17.05
14.45
New perspectives in acute leukemias
Giovanni Martinelli
Ponatinib: bridge to transplant
and post transplant clinical
strategies
Fabio Ciceri
17.20
15.00
Arsenic trioxide: many stories
about an old product
Giuseppe Rossi
Conclusions and general
discussion
Angelo M. Carella
17.30
Round Table
BONE MARROW
TRANSPLANTATION IN
LEUKEMIAS: NEW PERSPECTIVES
15.15
New prospective in hematology
Daniele Alberti
15.30
The use of an adaptive trial
design in a phase III trial of
Vosaroxin and Cytarabine in
relapsed and refractory AML
Adam Craig
16.00
New drugs anti-leukemia
Danilo Perrotti
Chairmen: Alberto Bosi
Andrea Bacigalupo
Immunologic pressure after
transplant and HLA
Fabio Ciceri
3
19.00
Unrelated donor transplant for
leukemia
Jane F. Apperley
9.20
Optimal non-transplant post
remission therapy
Jacob M. Rowe
Finding a donor for most eligible
patients
William Arcese
9.40
Allogeneic transplant for older
patients: GITMO experience
Alessandro Rambaldi
HDCT in MDS: indications, timing
and optimization of the results.
What’s new?
Emanuele Angelucci
10.00
Therapy of a fit 70 years old
individual
Richard F. Schlenk
10.20
APL in 2014: next challenges
for the final cure
Francesco Lo Coco
10.40
Conclusions and general
discussion
Sergio Amadori
10.45
Coffee break
11.00
Plenary Lecture
Regulation of self renewal
in cancer stem cells
Pier Giuseppe Pelicci
Presented by: Roberto M. Lemoli
End of session
THURSDAY, MAY 22
8.00
Opening Ceremony
ACUTE MYELOID LEUKEMIAS IN 2014:
SOME UNRESOLVED ISSUES
Chairmen: Jacob M. Rowe
Sergio Amadori
8.15
Introduction
Jacob M. Rowe
8.20
The increasing role of mutations
and genomics
Brunangelo Falini
8.40
9.00
4
The increasing clinical relevance
of minimal residual disease
Gert J. Ossenkoppele
Is there a role of adjunctive
therapy to standard 3+7?
Alan K. Burnett
SEPSIS AND SEPTIC SHOCK IN
HEMATOLOGICAL NEOPLASIAS
Chairman: Francesco Menichetti
11.30
Pathophysiology and clinical
features
Valerio Del Bono
11.50
Infections with multidrugresistant pathogens
Gian Maria Rossolini
12.10
Neutropenic Enterocolitis: a life
threatening complications
Edoardo Benedetti
12.30
IgM concentrated: rationale for
its use in hematology in the era
of “bad bugs”
Fabio Tumietto
12.50
13.15
16.30
Ultra-high risk patients: definition
and treatment pathway in the era
of novel drug landscape
Peter Dreger
16.50
Break
17.10
IgM enriched immunoglobulins
and defribotide after allogenic
hematopoietic transplantation
in acute leukemia
Giuseppe Milone
Second line therapy: what are
the options today?
Véronique Leblond
17.30
Immunotherapeutic strategies
including transplant
John G. Gribben
Lunch
17.50
A look at the future: new
options?
George Follows
18.10
Conclusions and general
discussion
Enrica Morra, Giovanni Pizzolo
CHRONIC LYMPHOCYTIC LEUKEMIA
Chairmen: Enrica Morra
Giovanni Pizzolo
15.00
Introduction
Manlio Ferrarini
15.10
NoTCH1 mutations: pathogenesis
and clinical significance
Davide Rossi
15.30
15.50
16.10
Transforming response prediction
to chemo-immunotherapy using
genome technologies
Anna Schuh
Do the next molecular markers
have an impact in treatment
strategy?
Gianluca Gaidano
First line therapy: which are
the options today?
Marco Montillo
FRIDAY, MAY 23
CHRONIC MYELOID LEUKEMIAS:
WHAT IS NEW?
Chairmen: Rudiger Hehlmann
Angelo M. Carella
8.00
Introduction
Rudiger Hehlmann
8.05
The basis for clinical
heterogeneity
Giuseppe Saglio
8.25
Initial choice of therapy
Michele Baccarani
5
8.45
Molecular monitoring
Andreas Hochhaus
9.05
9.25
9.45
11.50
Alternative approaches in
eradicating the malignant clone
Richard A. Van Etten
New markers for the diagnosis
of ALL: including NGS?
Robin Foà / Sabina Chiaretti
12.10
Early molecular response is
predictive of long-term outcome?
Susan Branford
Minimal residual disease:
comparison of different methods
Monika Brüggemann
12.30
Current clinical options after
resistance/intolerance to 1G/2G TKIs
Fabrizio Pane
Current treatment results
without antibodies
Renato Bassan
12.50
Antibody therapy
Dieter Hoelzer
10.05
Blastic crisis management
Rudiger Hehlmann
13.10
Targeted therapy
Oliver G. Ottmann
10.25
When should we transplant?
Jane Apperley
13.30
Lunch
Coffee break
15.00
10.45
11.00
Safety profiles of different TKIs
Carlo Gambacorti-Passerini
Risk factors and therapy in adult
T-ALL
Vahid Asnafi
15.20
How will we manage CML in the
next decade?
Stephen O’Brien
Stem cell transplantation
Andrea Bacigalupo
15.40
Conclusions and general
discussion
Angelo M. Carella
Conclusions and general
discussion
Felicetto Ferrara
16.00
Break
11.20
11.40
NEW MOLECULAR INSIGHTS AND
THERAPEUTIC STRATEGIES IN ACUTE
LYMPHOCYTIC LEUKEMIA
Chairmen: Dieter Hoelzer
Felicetto Ferrara
11.45
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Introduction
Dieter Hoelzer
MYELODYSPLASTIC SYNDROMES
Chairmen: Giorgina Specchia
Pellegrino Musto
16.15
Introduction
Giorgina Specchia
16.20
Classification
Pellegrino Musto
16.40
Prognostic models to predict
survival
Valeria Santini
17.00
Low-risk patients with deletions
in chromosome 5
Esther N. Oliva
9.50
Therapeutic challenges in PV
and ET patients conventionally
classified at low-risk for
thrombosis
Tiziano Barbui
10.10
Prefibrotic myelofibrosis:
a diagnosis that counts
Giovanni Barosi
10.30
Are we ready for treatment
recommendations with
Ruxolitinib in myelofibrosis?
Jean-Jacques Kiladjian
17.20
Therapeutic strategies
Giorgina Specchia
17.40
Five years after Azacitidine
approval: remaining challenges
Thomas Prebet
18.00
Who should be transplanted and
when?
Maria Teresa Voso
10.50
Deciding hematopoietic stemcell transplant in myelofibrosis
Nicolaus Kröger
18.20
Conclusions and general
discussion
Pellegrino Musto
11.10
Conclusions and general
discussion
Marco Gobbi
11.40
End of the conference
SATURDAY, MAY 24
PH-NEGATIVE MYELOPROLIFERATIVE
SYNDROMES
Chairmen: Tiziano Barbui
Marco Gobbi
9.00
Introduction
Tiziano Barbui
9.10
Molecular diagnosis of MPNs
in practice
Robert Kralovics
9.30
Molecular prognostic profiling
in primitive myelofibrosis
Alessandro Vannucchi
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SCIENTIFIC COORDINATORS
Angelo Michele Carella
U.O.C. Ematologia I
IRCCS A.O.U.
San Martino-IST
Genova (I)
Felicetto Ferrara
U.O. Ematologia
e Trapianto di Midollo Osseo
A.O. A. Cardarelli
Napoli (I)
Enrica Morra
U.O. Ematologia
e Trapianto di Midollo
A.O. Ospedale Niguarda
Cà Granda
Milano (I)
SPEAKERS AND CHAIRMEN
Daniele Alberti, Origgio, MI (I)
Sergio Amadori, Roma (I)
Emanuele Angelucci, Cagliari (I)
Jane F. Apperley, London (UK)
William Arcese, Roma (I)
Vahid Asnafi, Paris (F)
Michele Baccarani, Bologna (I)
Andrea Bacigalupo, Genova (I)
Tiziano Barbui, Bergamo (I)
Giovanni Barosi, Pavia (I)
Renato Bassan, Venezia (I)
Edoardo Benedetti, Pisa (I)
Alf Bernhardt, Basel (CH)
Alberto Bosi, Firenze (I)
Susan Branford, Adelaide (AUS)
Monika Brüggemann, Kiel (D)
Alan K. Burnett, Cardiff (UK)
James Carmichael, Seville (S)
Sabina Chiaretti, Roma (I)
Fabio Ciceri, Milano (I)
Adam Craig, South San
Francisco (USA)
Valerio Del Bono, Genova (I)
Peter Dreger, Heidelberg (D)
Andreas Engert, Cologne (D)
Brunangelo Falini, Perugia (I)
Massimo Federico, Modena (I)
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Manlio Ferrarini, Genova (I)
George Follows, Cambridge (UK)
Robin Foà, Roma (I)
Gianluca Gaidano, Novara (I)
Carlo Gambacorti-Passerini,
Monza (I)
Marco Gobbi, Genova (I)
John G. Gribben, London (UK)
Rudiger Hehlmann, Heidelberg
(D)
Andreas Hochhaus, Jena (D)
Dieter Hoelzer, Frankfurt (D)
Jean-Jacques Kiladjian, Paris (F)
Robert Kralovics, Vienna (A)
Nicolaus Kröger, Hamburg (D)
Véronique Leblond, Paris (F)
Roberto M. Lemoli, Genova (I)
Francesco Lo Coco, Roma (I)
Giovanni Martinelli, Bologna (I)
Francesco Menichetti, Pisa (I)
Giuseppe Milone, Catania (I)
Marco Montillo, Milano (I)
Pellegrino Musto, Rionero in
Vulture, PZ (I)
Stephen O’Brien, Newcastle (UK)
Esther Natalie Oliva, Reggio
Calabria (I)
Gert J. Ossenkoppele,
Amsterdam (NL)
Oliver G. Ottmann, Frankfurt (D)
Fabrizio Pane, Napoli (I)
Pier Giuseppe Pelicci, Milano (I)
Danilo Perrotti, Baltimore (USA)
Giovanni Pizzolo, Verona (I)
Thomas Prebet, Marseille (F)
Alessandro Rambaldi,
Bergamo (I)
Davide Rossi, Novara (I)
Giuseppe Rossi, Brescia (I)
Gian Maria Rossolini, Siena (I)
Jacob M. Rowe, Jerusalem (IL)
Giuseppe Saglio, Orbassano,
TO (I)
Valeria Santini, Firenze (I)
Richard F. Schlenk, Ulm (D)
Anna Schuh, Oxford (UK)
Giorgina Specchia, Bari (I)
Fabio Tumietto, Bologna (I)
Richard A. Van Etten, Orange
CA, (USA)
Alessandro M. Vannucchi,
Firenze (I)
Maria Teresa Voso, Roma (I)
Pier Luigi Zinzani, Bologna (I)
CME
Based on Italian regulations, Accademia Nazionale di Medicina (provider n. 31) will assign
16,5 CME credits to the activity 31-86981.
The Meeting is addressed to Physicians specialized in Hematology, Oncology and Biologists.
It will not be possible to give Credits to physicians specialized in different fields.
The credit certification is subject to:
- attendance at the entire Meeting
- the completion of the Meeting evaluation form
- the completion of the final questionnaire (at least 75% of correct answers)
REGISTRATION
The registration fee is € 150,00 tax free.
To register, please send:
- registration form duly filled out (even when sponsored by a Pharmaceutical Company)
- privacy statement and consent regarding personal information (back of the form)
- payment to Accademia Nazionale di Medicina – Via Martin Piaggio 17/6 - 16122 Genova
fax 010 83794260 – email: [email protected], by May 12, 2014
Online registration is possible on the website www.accmed.org
By submitting the form and the payment, your registration is completed with the
exception of specific decisions of the Meeting Secretariat.
Incomplete registration will not be admitted.
The registration will be confirmed by e-mail, please indicate your e-mail address on the
registration form.
Cancellation
- If the participants minimum number is not reached, Accademia Nazionale di Medicina
will advise by a written communication and proceed with the total refund of the fee.
- In order to cancel please give advise with a written communication to Accademia
Nazionale di Medicina within 10 days from the beginning. A 70% of the registration fee
will be returned. Cancellations after that deadline will not be refounded.
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VENUE
PROMOTED BY
Grand Hotel Miramare
Via Milite Ignoto, 30
Santa Margherita Ligure (GE), Italy
ACCADEMIA NAZIONALE DI MEDICINA
How to reach the meeting venue:
By train
the nearest train station is Santa
Margherita Ligure, located 1,5 km from
the meeting venue.
By car
From A12 motorway please take “Rapallo”
exit an then follow signs to Santa
Margherita Ligure (about 5 km) and
continue on the road along the seaside.
Grand Hotel Miramare is located just a few
meters after S. Margherita port.
By plane
Genoa airport is located 30 km away from
the meeting venue.
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www.accmed.org
General Manager: Stefania Ledda
ORGANIZING PARTNER
Forum Service
Via Martin Piaggio 17/6
16122 Genoa
Information and registration
Ph. +39 010 83794233
Fax +39 010 83794260
[email protected]
Hotel booking
Ph. +39 010 83794233
Fax +39 010 83794261
[email protected]
WITH THE PATRONAGE OF
Società Italiana di Ematologia - SIE
Società Italiana di Ematologia Sperimentale - SIES
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