ItPA IX Annual Congress Centro Congressi Federico II Via Partenope 36 - Napoli 2 IX ItPA National Congress Napoli, June 24th-27th, 2014 SCIENTIFIC PROGRAM TUESDAY 24 JUNE 11.00 – 16.00 Meeting Registration 12.15 – 14.15 Luncheon Seminar sponsored by AB Sciex Extending the Power of SWATH™ Acquisition - Advances in Data Acquisition and Processing Francesco Brancia, AB SCIEX 17.00 – 18.30 Opening Ceremony Andrea Urbani, Piero Pucci, Piero Salatino, Francesco Salvatore, Gennaro Marino Chair: Francesco Salvatore Opening Lecture Proteomic Clinical Assays Based on High-Resolution / Accurate Mass Spectrometry Bruno Domon,Luxembourg ClinicalProteomicsCenter, Centre de Recherche Public de la Santé (CRP-Santé), Luxemburg 18.30 – 20.00 Welcome Party Salone delle Feste Centro Congressi Partenope WEDNESDAY 25 JUNE SESSION I: TECHNOLOGIES SESSION Chair: Gennaro Marino, Alessandra Modesti 09.00 – 09.45 Keynote Lecture Imaging Mass Spectrometry in the Clinic Liam A. McDonnell Fondazione Pisana per la Scienza, Pisa, Italy Leiden University Medical Center, Leiden, NL 09.45 – 10.15 Distinguished Speaker The human salivary proteome and peptidome characterized by a gel-free integrated top-down and bottom-up approach Irene Messana, University of Cagliari, Cagliari, Italy 10.20 – 10.50 Coffee break 3 Chair: Massimo Castagnola,Angela Amoresano 10.50 – 11.05 Calpain-dependent cleavage in highly activated platelets revealed by quantitative N-terminal ChaFRADIC: alterations in Scott syndrome Fiorella A. Solari,Leibniz-Institut für Analytische WissenschaftenISASe.V., Dortmund, Germany 11.05 – 11.20 Targeted metabolomics in the screening of inborn errors of metabolism Emanuela Scolamiero, CEINGE-Biotecnologie Avanzate scarl,Naples, Italy 11.20 – 11.35 A PSA Guided Approach for a Better Diagnosis of Prostatic Adenocarcinoma Based on MALDI Profiling Chiara Fania,Dept. Biomedical Sciences for Health, University of Milan, IRCCS Policlinico San Donato, San Donato (MI), Italy 11.35 – 11.50 DJ-1 as a potential biomarker for sub-type differential diagnosis in endometrial cancer Domenica Scumaci,Laboratory of Proteomics, Dpt. of Experimental andClinical Medicine, Magna Græcia University of Catanzaro 11.50 – 12.05 Effect of salt intake in hypertension revealed by urinary quantitative proteomic Vittoria Matafora, IFOM-FIRC Institute of Molecular Oncology, Italy 12.15 – 14.15 Luncheon Seminar sponsored by Thermofisher Protein Quantitative Analysis using the Orbitrap Analyzer Michaela Scigelova, Thermo Fischer Scientific Innovative LC workflows for difficult and complex samples in Omics research Debora D’Addona,Thermo Fischer Scientific SESSION II: HUMAN PROTEOMICS Chair: Luca Bini, Ferdinando Palmieri 14.30 – 15.15 Keynote Lecture What Proteomics can tell us about Platelets! Albert Sickmann, Leibniz-Institut für Analytische Wissenschaften – ISAS - e.V, Dortmund, Germany President of German Proteomics Society 4 IX ItPA National Congress Napoli, June 24th-27th, 2014 15.15 – 15.45 15.50 – 17.00 Distinguished Speaker Contribution of the Italian Human Proteome Network to Proteomics Cecilia Gelfi, Dept. Biomedical Sciences for Health, University of Milan, IRCCS Policlinico San Donato, San Donato (MI), Italy Coffee break and POSTER SECTION 1 – Odd Numbers Chair: Margherita Ruoppolo, Paolo Pedone 17.00 – 17.15 Proteomic integrated platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors Claudia Martelli, Istituto di Biochimica e Biochimica Clinica, Universita’ Cattolica del Sacro Cuore, Rome, Italy. 17.15– 17.30 Investigation of molecular mechanisms impaired in Wilson disease Diana Canetti, Department of Chemical SciencesUniversity of Naples “Federico II” and Interuniversity Consortium of Structural and Systems Biology (I.N.B.B.), Italy 17.30– 17.45 Fibroblasts transfer lipids and proteins to cancer cells through cargo vesicles supporting tumor growth Alice Santi, Dipartimento di Scienze Biomediche Sperimentali e Cliniche, Sezione di Biochimica, Università degli Studi di Firenze, Italy 17.45– 18.00 Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells Angela Chambery,Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Second University of Naples, Caserta, Italy 18.00 – 19.00 ItPA General Assembly THURSDAY 26 JUNE SESSION III: NON-HUMAN PROTEOMICS Chair: Paola Roncada, Lello Zolla 09.00 – 09.45 Keynote Lecture Deciphering bacteria through proteomics Véronique Monnet, INRA, AgroParisTech, UMR1319 MICALIS, plateforme PAPPSO, 78352 Jouy-en-Josas, FRANCE 5 09.45 – 10.15 Distinguished Speaker Protein digestomics: integrated platforms to study food protein digestion Pasquale Ferranti, Department of Agriculture, University of Napoli ‘Federico II’, Portici, Italy 10.20 – 10.50 Coffee break Chair: Anna Maria Timperio, Andrea Scaloni 10.50– 11.05 Microbiota dynamics in cheese production Alessio Soggiu, Dipartimento di Scienze Veterinarie e Sanità Pubblica, Università di Milano, Milano, Italy 11.05 - 11.20 Off gel proteomics of Cupriavidus metallidurans CH34 in artificial soil under Viable But Non Culturable state Laura Giagnoni, Department of Agrifood Production and Environmental Sciences, University of Florence, Firenze, Italy 11.20 - 11.35 Role of infection in reproduction: bovine endometrial cell model Cristian Piras, Dipartimento di Scienze Veterinarie e Sanità Pubblica, Università degli studi di Milano, Milano, Italy 11.35 - 11.50 A first insight into the Asian clay sculptures painting techniques and materials: use of proteomics strategies onthe Buddhas of the Bamiyan Valley (Afghanistan) Roberto Vinciguerra, Department of Chemical Sciences, University of Naples “Federico II”, Naples, Italy 11.50–12.05 Proteomic investigation of the pathogenetic mechanisms of amyotrophic lateral sclerosis: the role of Ubiquilin2 Serena Camerini, Dept. of Cell Biology and Neurosciences Higher Institute of Health (ISS), Rome, Italy 12.15 – 14.15 Luncheon Seminar sponsored by Agilent Technologies Benedikt Kessler, Oxford University SESSION IV: SYSTEMS BIOLOGY Chair: Mauro Fasano, Alfredo Budillon 14.30 – 15.15 Keynote Lecture Mass-spectrometry-based draft of the human proteome Bernhard Kuster, Chair of Proteomics and Bioanalytics, Technische Universitaet Muenchen, Germany 6 IX ItPA National Congress Napoli, June 24th-27th, 2014 15.15 – 15.30 15.50 – 17.00 Distinguished Speaker Integrative Bioinformatics and Systems Biology for Biomarker in Cancer Genomics Michele Ceccarelli, University of Sannio, Benevento, Bioinformatics Lab, BIOGEM, Ariano Irpino, Italy Coffee break and POSTER SECTION 2 – Even Numbers Chair: Alessandra Modesti, Angelo Facchiano 17.00 – 17.15 Proteomics unveils novel targets of miR-494 involved in senescence Mariangela Succoio, Dipartimento Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, CEINGEBiotecnologie Avanzate s.c. a r.l, Napoli, Italy 17.15 – 17.30 From interaction to function: Phospholipase C beta 1 protects cells from stress-induced apoptosis. Manuela Piazzi, Cell Signaling Laboratory, Department of Biomedical Science, University of Bologna, Italy 17.30 – 17.45 Functional proteomic analysis of the mechanisms of proteotoxicity in cardiac light chain (AL) amyloidosis Francesca Lavatelli, Amyloidosis Research and Treatment Center, Foundation Scientific Institute San Matteo, Department of Molecular Medicine, University of Pavia, Italy 17.45 – 18.00 Synergistic effect of DHT and IGF-1 hyperstimulation in human peripheral blood lymphocytes Stefania OrrùDipartimento di Scienze Motorie e del Benessere (DiSMeB) UniversityPartenope Naples Italy 18.00 – 18.15 Proteomics analysis of E-Cadherin knockdown in epithelial breast cancer cells Daniele Vergara, Department of Biological and Environmental Sciences and Technologies, University of Salento, via Monteroni, Lecce, Italy 19.30 Social Dinner – Castel dell’Ovo - Loggiato Ovest 7 FRIDAY 27 JUNE Chair: Andrea Urbani, Gianni Capasso 09.00 – 10.30 POSTER PRIZES 10.30 – 11.00 Coffee break 11.00 – 11.45 12.00 – 12.30 Closing Lecture Transcription factor control of naïve and primed states of pluripotency Antonio Simeone, Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, CNR, Naples, Italy Closing Remarks: Andrea Urbani, Piero Pucci 8 IX ItPA National Congress Napoli, June 24th-27th, 2014