Seattle Children’s Hospital and the Department of Pediatrics, University of Washington School of Medicine Seattle Children’s Hospital and the Department of Pediatrics, University of Washington School of Medicine 2005 Academic Annual Report 2005 Academic Annual Report 4800 Sand Point Way N.E. Seattle, Washington 98105 (206) 987-2000 www.seattlechildrens.org В© 2006 Children’s Hospital and Regional Medical Center, Seattle, Washington. All rights reserved. 10/06 Our Vision We will be the best children’s hospital Our Mission WE WILL: > Provide patients and their families excellent care with compassion and respect We believe all children have unique needs and should grow up without illness or injury. With the support of the community and through our spirit of inquiry, we will prevent, treat and eliminate pediatric disease. > Deliver superior, accessible, cost-effective service > Attract and retain the best talent at all levels of the organization > Be one of the top five pediatric research institutions in the country > Be the nation’s premier pediatric educator > Achieve worldwide prominence by integrating patient care, research, education and advocacy Our Vision We will be the best children’s hospital WE WILL: > Provide patients and their families excellent care with compassion and respect > Deliver superior, accessible, cost-effective service > Attract and retain the best talent at all levels of the organization > Be one of the top five pediatric research institutions in the country > Be the nation’s premier pediatric educator > Achieve worldwide prominence by integrating patient care, research, education and advocacy Message from the President and CEO Thomas N. Hansen, MD DEAR COLLEAGUES AND FRIENDS, I am pleased to share this annual report describing the work of Seattle Children’s Hospital and Regional Medical Center. From its beginnings nearly 100 years ago, Seattle Children’s has emerged as a world leader in pediatric health care. We are the primary pediatric referral center for the four-state region that includes Washington, Alaska, Montana and Idaho. In addition to providing high-tech patient care, our research is advancing the way pediatric medicine is practiced throughout the world. Our vital link to the University of Washington — which has one of the nation’s best medical schools — allows us to look confidently to the future as we train the next generation of physicians who will focus on the health care of children. Two-thirds of our faculty trained at the University of Washington School of Medicine, and many serve in key national leadership positions across a broad spectrum of academic pediatrics and biomedical research. Several achievements and milestones during the past year are worth highlighting. In July 2005, Seattle Children’s hosted the first conference of the newly established Treuman Katz Center for Pediatric Bioethics. On Oct. 1, 2005, I became president and CEO of Seattle Children’s, succeeding Treuman Katz who had served in that capacity for the past 26 years. In December 2005, we announced plans to add 1 million square feet of research space during the next decade. In February 2006, we introduced a $300 million fundraising campaign to support uncompensated care, research and facility development. Also in February, we began developing a five-year strategic plan to lay the foundation for our next 100 years. The Board of Trustees unanimously approved this plan and launched us on our journey to become the “best children’s hospital.” In April 2006, we dedicated the Melinda French Gates Ambulatory Care Building, which consolidates nearly all of our clinical outpatient services in one state-of-the-art facility. Most recently, we placed 12th in the nation in pediatrics in the U.S.News & World Report’s вЂ�America’s Best Hospitals,’ and we were the highest ranked pediatric hospital on the West Coast. Our mission is to prevent, treat and eliminate pediatric disease. It is a lofty goal — but great accomplishments do not come from small ambitions. I hope you will take time to read about our achievements and the faculty who have helped make us one of the best pediatric medical centers in the country. Thomas N. Hansen, MD President and CEO Seattle Children’s Hospital and Regional Medical Center SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 1 Message from the Vice President for Medical Affairs and Dean of the University of Washington School of Medicine Paul G. Ramsey, MD DEAR COLLEAGUES AND FRIENDS, I am honored to join Seattle Children’s Hospital and Regional Medical Center in celebrating the many achievements of University of Washington pediatrics faculty. The information presented in this annual report demonstrates the dynamic link between Seattle Children’s and UW Medicine. This partnership is dedicated to improving the health of children by advancing medical knowledge, providing outstanding primary and specialty pediatric medical care and training the next generation of health professionals. Seattle Children’s provides inpatient facilities for the majority of children hospitalized within the UW-affiliated system and is where many of our medical students learn pediatrics. UW–Seattle Children’s pediatrics residency program is one of the most sought-after residencies in the United States and is educating the pediatrics leaders of tomorrow. UW Medicine pediatrics faculty are world leaders in biomedical research, innovators in education, and nationally recognized for patient care. Through excellence, innovation and collaboration, UW Medicine pediatrics faculty are improving the health of children everywhere. I am pleased to welcome Dr. Tom Hansen to Seattle as president and CEO of Seattle Children’s and as a member of our faculty. I am personally committed to working closely with him and with our faculty leadership to achieve Seattle Children’s vision to be the “best children’s hospital” anywhere. Paul G. Ramsey, MD Dean, University of Washington School of Medicine 2 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Executive Staff Thomas N. Hansen, MD President, Chief Executive Officer Richard Molteni, MD Vice President, Medical Director Jeffrey Sconyers Vice President, General Counsel Patrick Hagan Executive Vice President, Chief Operating Officer Douglas Picha Vice President, Executive Director, Children’s Hospital Foundation F. Bruder Stapleton, MD Pediatrician-in-Chief James Hendricks, PhD Vice President, Research Robert Sawin, MD Surgeon-in-Chief Kelly Wallace Vice President, Chief Financial Officer Sanford Melzer, MD Vice President, Strategic Planning and Business Development SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 3 Welcome 2005 was a year of achievement for Seattle Children’s Hospital Drs. Michael Cunningham and Richard Hopper co-direct Seattle Children’s Craniofacial Center and collaborate closely to provide the best medical and surgical outcomes to their patients. 4 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON T O P L E F T: Dr. Corrie Anderson leads Seattle Children’s pain management team. T O P R I G H T: Infectious disease researcher Dr. Amanda Jones Children enjoy the open feel and engaging artwork in the new Melinda French Gates Ambulatory Care Building. O T H E R P H O T O S T H I S PA G E : Seattle Children’s Hospital was founded in Seattle in 1907 on the belief that all children deserve medical care that addresses their unique needs. During the past century, we have blossomed into one of the best academic pediatric medical centers in the nation. We now provide inpatient, outpatient, diagnostic, emergency, outreach and telemedicine services in nearly 60 pediatric subspecialties. The key elements of our mission are to prevent, treat and eliminate pediatric disease, and everything we do is designed to help us achieve these goals. We take pride in our role as the region’s primary pediatrics teaching resource, training pediatrics specialists, family practitioners, nurses, technicians, dentists and postdoctoral researchers. In partnership with the University of Washington School of Medicine, our residency program offers more than 50 fellowships each year and is consistently ranked among the best in the nation. Our state-of-the-art facilities support a high-tech, high-touch approach to patient care. In the past two years, we have opened two new buildings that have expanded our capacity to deliver complex, highintensity care in both the inpatient and ambulatory settings. Our flourishing research program is the engine that drives our success. It produces the discoveries that transform the way medicine is practiced. It attracts the best doctors, nurses, scientists and staff. It brings new hope to children and families battling life-threatening illnesses and chronic conditions. So in late 2005, Seattle Children’s announced plans to add 1 million square feet of research space during the next decade. Ultimately, we owe our success to the dedicated faculty and staff who work tirelessly on behalf of children. Their care and compassion at the bedside motivate their search for scientiп¬Ѓc discoveries at the bench. We also are grateful to our generous community, whose philanthropic support helps assure our legacy to provide the best care for children. This report details the teaching, research and clinical highlights of 2005 and the faculty expertise behind them. Turn the page and share our energy, our excitement, our commitment to pediatric medicine and research — and our ultimate goal of improving the lives of children everywhere. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 5 2005 Achievements > The Treuman Katz Center for Pediatric Bioethics at Seattle Children’s — one of the nation’s п¬Ѓrst centers dedicated to the study of research and health care for children — hosted its п¬Ѓrst conference in July 2005. Presenters, panelists and attendees discussed the ethical issues that arise when children are involved in medical research. > Bone marrow transplant pioneer Dr. Jean Sanders completed a longitudinal study of infants with acute lymphoblastic leukemia. It showed that infants who received total-body radiation and bone marrow transplants had a vastly better disease-free survival rate than those treated with chemotherapy alone. Additionally, they did not suffer long-term harmful effects from the initial radiation treatment. > Drs. Craig Rubens and Amanda Jones contributed to a national study that found that the genetic material of bacteria and viruses evolves as much as 30 percent from one strain to the next. Dr. Danielle Zerr investigates the impact of infectious diseases on immunosuppressed patients; Dr. Ernest Conrad develops limb-sparing surgeries for children with bone tumors; Dr. Jean Sanders pioneers bone marrow transplant protocols. C LO C K W I S E F R O M TO P : 6 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON > Seattle Children’s established the only small intestine transplant program in the Northwest — and one of only a handful in the country — under the leadership of pioneering surgeon Dr. Jorge Reyes. Organ transplant pioneer Dr. Jorge Reyes is improving surgical techniques for split-liver and living-donor liver transplantations. > Dr. Dimitri Christakis and Michelle Garrison found no scientiп¬Ѓc evidence that “educational” media products have any educational value for babies and toddlers. > In the most comprehensive study ever conducted on infants hospitalized with bronchiolitis, Dr. Christakis and his team found that shortening hospital stays and eliminating unnecessary medications and tests can enhance patient safety and will likely lower treatment costs. The study also found considerable differences in the way the illness is treated at 30 large children’s hospitals across the United States. > Dr. Christakis and Dr. Frederick J. Zimmerman published a study that showed that the more TV children watched between the ages of 1 and 3, the greater their risk of attention problems by age 7. > A team of Seattle Children’s and University of Washington researchers, led by Dr. Danielle Zerr, uncovered new information about when and how the human herpesvirus 6 is acquired, its symptoms and the length of time the virus is active in toddlers. > Dr. Zerr also led a study showing that there were fewer hospitalacquired infections in hospitals where staff had access to alcohol gel for disinfecting their hands than at those hospitals without regular alcohol hand-gel programs. The study used data from 31 children’s hospitals and more then 48,000 patients. > As part of a national, multisite study sponsored by the National Institutes of Health (NIH), Dr. James Stout and his team showed that home visits and education on reducing exposure to allergens and tobacco smoke in the home signiп¬Ѓcantly improved the health of children with asthma. > Seattle Children’s nursing program began a multiyear journey to attain Magnet status from the American Nurses Association. > Eighty-nine members of Seattle Children’s medical staff were included in Seattle magazine’s annual list of top doctors in the Seattle area. The magazine also listed 11 of Seattle Children’s medical staff among Seattle’s best dentists. > Seattle Children’s became the п¬Ѓrst medical center west of the Mississippi to perform a heart transplant on an infant whose blood type was different than the organ donor’s (known as an ABO-mismatched transplant). > Dr. David Rawlings and his team identiп¬Ѓed the trigger that activates a pathway in T and B immune cells that leads to the survival and growth of these cells. This discovery could ultimately lead to more effective treatments of cancers and autoimmune diseases. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 7 Leadership in Faculty and Programs Dr. Richard Ellenbogen is president of the Congress of Neurological Surgeons; Dr. Frederick Rivara was elected to the Institute of Medicine of the National Academies; Elizabeth McCauley, PhD, was among the п¬Ѓrst to recognize depression as a childhood illness. C L O C K W I S E F R O M L E F T: 8 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Renowned cancer researcher Dr. Irwin Bernstein Endowed Chairs Professional Appointments Irwin D. Bernstein, MD, John R. Hartmann Endowed Chair in Pediatric Oncology/Hematology, University of Washington Phillip F. Chance, MD, Medical Advisory Committee, Muscular Dystrophy Association; Chairman, Scientific Review Committee, Les Turner ALS Association Robert J. Boucek Jr., MD, MS, Thomas Bradley Armstrong Endowed Chair in Pediatric Cardiology, Seattle Children’s Phillip F. Chance, MD, Allan and Phyllis Treuer Endowed Chair in Genetics and Development, Seattle Children’s Gordon A. Cohen, MD, PhD, Sam and Althea Stroum Endowed Chair in Pediatric Cardiovascular Surgery, Seattle Children’s Michael L. Cunningham MD, PhD, Jean Renny Endowed Chair in Pediatric Craniofacial Medicine, Seattle Children’s Benjamin S. Danielson, MD, Janet and Jim Sinegal Endowed Chair for the Odessa Brown Children’s Clinic, Seattle Children’s Richard G. Ellenbogen, MD, Theodore S. Roberts Endowed Chair in Pediatric Neurosurgery, Seattle Children’s J. Russell Geyer, MD, Evans Family Endowed Chair in Pediatric Cancer, Seattle Children’s Richard G. Ellenbogen, MD, President, Congress of Neurological Surgeons (CNS) Debra L. Friedman, MD, Director, Fred Hutchinson Cancer Research Center Survivorship Program John M. Neff, MD, Council on University Relations, University of Washington Frederick P. Rivara, MD, MPH, Elected Member, Institute of Medicine (IOM) of the National Academies Academic Journal Editors and Board Members Michael E. Mitchell, MD, Dr. Michael Mitchell Endowed Chair in Pediatric Urology, Seattle Children’s Robert J. Boucek Jr., MD, MS, Editorial Board Member, Journal of Heart and Lung Transplantation F. Bruder Stapleton, MD, Ford Morgan Endowed Chair, University of Washington Kenneth M. Jaffe, MD, Editor-in-Chief, Archives of Physical Medicine and Rehabilitation; Editorial Board Member, Journal of Brain Injury Scott C. Manning, MD, Editorial Board Member, Otolaryngology — Head and Neck Surgery Vincent S. Mosca, MD, Editorial Board Member, Journal of Pediatric Orthopedics Irwin D. Bernstein, MD, Consulting Editor, Journal of Clinical Investigation; Editorial Board Member, Current Cancer Therapy Reviews Jean E. Sanders, MD, Gerald and Gloria Swanson Endowed Chair in Pediatric Bone Marrow Transplantation, Seattle Children’s Simon P. Horslen, MBChB, FRCPCH, Chair, Joint Pediatric Liver and Intestine Subcommittee, United Network for Organ Sharing (UNOS) Sandra L. Watkins, MD, President, American Society of Pediatric Nephrology Joseph S. Gruss, MD, Marlys C. Larson Endowed Chair in Pediatric Craniofacial Surgery, Seattle Children’s Craig E. Rubens, MD, PhD, Children’s Hospital Guild Association Endowed Chair in Pediatric Infectious Disease Research, Seattle Children’s James Hendricks, PhD, Editor-in-Chief, Journal of Histotechnology Elizabeth A. McCauley, PhD, Editorial Board Member, Journal of Abnormal Child Psychology Abraham B. Bergman, MD, Associate Editor, Archives of Pediatrics and Adolescent Medicine Bonnie W. Ramsey, MD, Bonnie Ramsey Endowed Chair in Cystic Fibrosis Research, University of Washington Sidney M. Gospe Jr., MD, PhD, Editorial Board Member, Pediatric Neurology F. Bruder Stapleton, MD, first annual Endowed Residency Visiting Professor, University of Florida Health Sciences Center in Jacksonville; elected President, Association of Medical School Department Chairs Sidney M. Gospe Jr., MD, PhD, Herman & Faye Sarkowsky Endowed Chair in Child Neurology, University of Washington Jeffrey G. Ojemann, MD, Richard G. Ellenbogen Endowed Chair in Pediatric Neurosurgery, Seattle Children’s Debra L. Friedman, MD, Pediatric Board Member, National Cancer Institute PDQ Dimitri A. Christakis, MD, Associate Editor, Archives of Pediatric and Adolescent Medicine Michael L. Cunningham, MD, Editorial Board Member, American Journal of Otolaryngology; Deputy Editor, Birth Defects Research Part A: Clinical and Molecular Teratology Allison A. Eddy, MD, Deputy Editor, Journal of the American Society of Nephrology; Editorial Board Member, Pediatric Nephrology Eric L. Effmann, MD, Editorial Board Member, Pediatric Radiology Richard G. Ellenbogen, MD, Editor, Science Times; Editorial Board Member, Neurosurgery Michael E. Mitchell, MD, Consulting Editor, Journal of Urology, Journal of Pediatric Surgery, Urology and European Journal of Urology Roberta A. Pagon, MD, Editorial Board Member, Genetics in Medicine Michael A. Portman, MD, Editorial Board Member, American Journal of Physiology — Heart and Circulatory Physiology David J. Rawlings, MD, Editorial Advisory Board Member, Clinical Immunology Jorge D. Reyes, MD, Editorial Board Member, Pediatric Transplantation, Current Opinions in Organ Transplantation, and Intestine; Member, Board of Directors, LifeCenter Northwest; Chair, Pediatric Transplantation Committee, United Network for Organ Sharing (UNOS) Frederick P. Rivara, MD, MPH, Editor, Archives of Pediatric and Adolescent Medicine; Deputy Editor, Injury Prevention; Founding President, International Society for Child and Adolescent Injury Prevention Craig E. Rubens, MD, PhD, Editorial Advisory Board Member, Future Microbiology F. Bruder Stapleton, MD, Editor-in-Chief, Journal Watch — Pediatrics and Adolescent Medicine Jerry J. Zimmerman, MD, PhD, Editorial Board Member, Critical Care Medicine and Pediatric Critical Care Medicine SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 9 Hematology and Oncology Finding Better Ways to Treat Brain Tumors in Kids JAMES M. OLSON, MD, PHD Titles Attending Physician, Seattle Children’s Hospital Assistant Program Head, Fred Hutchinson Cancer Research Center Pediatric Oncology Program Adjunct Associate Professor of Pathology, University of Washington School of Medicine Associate Professor of Pediatric Hematology/ Oncology, University of Washington School of Medicine Founder, Olson Lab at Fred Hutchinson Cancer Research Center Editorships and Appointments Young Investigators Committee Member and Biology and Translational Research Committee Member, Children’s Oncology Group Director, Hereditary Disease Array Group Scientific Advisory Board Member, Hereditary Disease Foundation Ad Hoc Reviewer, Multiple Study Sections, National Institutes of Health and the Medical Research Council of Great Britain 10 In only six years, Dr. James Olson and his research team have broken new ground in the п¬Ѓght against brain tumors. His lab was the п¬Ѓrst to identify growth pathways of medulloblastoma cells that are not essential for the body’s other cells. This discovery has opened the door to developing targeted cancer therapies that are more effective and less toxic: more effective because they can interrupt the signaling pathways cancer cells need to stay alive; less toxic because they leave non-cancerous cells untouched. So far, the team has identiп¬Ѓed three vulnerable growth pathways. The method Olson’s team developed has become the standard for studying growth pathways in other types of cancer — and his laboratory has also become the national reference lab for performing tissue culture studies on medulloblastoma samples sent by 240 institutions that treat this cancer. By analyzing the effectiveness of therapeutic agents in lab and mouse models, Olson’s team helps prioritize which drugs should be brought to clinical trial. Their studies have resulted in three national clinical trials, including a Phase III trial testing to see if their recommended therapy — simple 13-cis-retinoic acid (also known as Accutane) in conjunction with cisplatin — should become the standard of care for treating medulloblastomas. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Improving surgical excision of brain tumors is another of Olson’s goals. He is working with renowned neurosurgeon Dr. Richard Ellenbogen, who leads Seattle Children’s neurosurgery division and chairs the Department of Neurological Surgery at the University of Washington School of Medicine, to develop tumor paint to help surgeons distinguish between cancer cells and normal brain tissue. Tumor paint utilizes a molecule that targets cancer cells and avoids normal brain cells. Olson’s team— which includes neurosurgeons, engineers and biologists — linked this molecule to another small molecule that emits a near-infrared light. In mouse models, they demonstrated that they could light up brain tumors as small as 1 millimeter in diameter without lighting up adjacent normal brain tissue. Used in the operating room, tumor paint will enable surgeons to clearly distinguish cancerous cells from normal tissue. Olson has п¬Ѓled a patent application on tumor paint and his team is preparing for the necessary toxicity studies before seeking approval from the Food and Drug Administration to begin clinical trials. “The unique collaboration between Children’s and the Fred Hutchinson Cancer Research Center provides a great environment for research. The philanthropic support has enabled us to do high-risk, highpayoff studies that can lead to true advances in medicine,” Olson says. Children’s multifaceted approach to pediatric oncology is a standout feature of our cancer program. Our efforts run the gamut from studying cancer at the molecular level, to developing and refining clinical treatments, to leading survivors into the future. Our collaboration with Fred Hutchinson Cancer Research Center and the University of Washington provides a unique, synergistic environment for this work. Surviving Is Just the First Step The good news is that the last 30 years have seen signiп¬Ѓcant increases in survival rates for children who battle cancer. But this growing cadre of survivors has shown that the cost of beating cancer can include many signiп¬Ѓcant health risks and an impaired quality of life. In the small but growing п¬Ѓeld that has emerged to address survivors’ needs, Dr. Debra Friedman is a leader. Her work addresses this multifaceted issue from a variety of angles. The model of care Friedman developed for long-term follow-up for childhood cancer survivors is being adapted by pediatric and adult survivorship programs throughout the country. Her work also has contributed to changes in treatment protocols for children, which should lessen the longterm adverse effects of both the disease and its cure. Friedman is leading a 13institution clinical trial, funded by the National Cancer Institute (NCI), to see if changes in the way Hodgkin lymphoma is treated — reducing the п¬Ѓeld and dose of radiation, lowering the dosage of some chemotherapy drugs and eliminating others — has improved long-term physical and emotional outcomes for patients. “We know the survival rate has improved, but we want to know if we’ve reduced the long-term physiologic effects, like cardiovascular disease, infertility, secondary cancers and fatigue,” Friedman says. “And if we have, will the psychological effects follow, or are they separate issues?” She is also leading two novel pilot studies on exercise and its role in enhancing a survivor’s quality of life both physically and socially. By improving patients’ п¬Ѓtness and their engagement in social activities, Friedman hopes to improve healthrelated quality of life and to address the growing problem of obesity and inactivity in childhood cancer survivors. Secondary malignancies are another area where Friedman is making inroads. She’s trying to tease out the environmental and genetic risk factors that may trigger second malignancies in some patients but not others who had the same diagnosis and underwent the same treatments. The ultimate goal is to modify either the environment or the treatment to lower the risk of developing a secondary cancer. In 2005, Friedman was appointed director of a new survivorship program at Fred Hutchinson Cancer Research Center (FHCRC), which is part of the LiveSTRONGTM Survivorship Center of Excellence Network. It is one of п¬Ѓve such centers in the nation funded by an invitation-only grant from the Lance Armstrong Foundation. The center is located in the outpatient clinic of the Seattle Cancer Care Alliance (SCCA) — which unites the cancer care services of Seattle Children’s, FHCRC and University of Washington Medicine. The center will expand clinical care, education and research for survivors of pediatric and medical oncology and of bone marrow and stem cell transplant, including adult survivors of pediatric malignancies. DEBRA L. FRIEDMAN, MD Titles Attending Physician, Seattle Children’s Hospital Founding Director, Children’s ACCESS program (After Cancer Care Ends Survivorship Starts) Director, Fred Hutchinson Cancer Research Center Survivorship Program Associate Professor, Department of Pediatrics, University of Washington School of Medicine Associate Member, Fred Hutchinson Cancer Research Center Editorships and Appointments Editorial Board Member, Children’s Oncology Group CureSearch Web site Pediatric Board Member, National Cancer Institute PDQ Member of several disease, strategy and study committees, Children’s Oncology Group “Our survivors are teaching us how to better care for them,” Friedman says. “Hopefully we can improve the outcome for the next generation until we can п¬Ѓgure out how to prevent cancer in the п¬Ѓrst place.” To learn more about the survivorship program call (866) 543-4272 or e-mail [email protected]. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 11 Craniofacial Treating What Children Know as Themselves MICHAEL L. CUNNINGHAM, MD, PHD Titles Jean Renny Endowed Chair in Pediatric Craniofacial Medicine, Seattle Children’s Hospital Medical Director, Seattle Children’s Craniofacial Center, Seattle Children’s Hospital Chief, Division of Craniofacial Medicine, University of Washington School of Medicine Associate Professor of Pediatrics, University of Washington School of Medicine Adjunct Associate Professor, Department of Biological Structure, University of Washington School of Medicine Adjunct Associate Professor, Department of Oral Biology, University of Washington School of Dentistry Editorships and Appointments Deputy Editor, Birth Defects Research Part A: Clinical and Molecular Teratology 12 The very nature of craniofacial conditions poses an interesting challenge in medicine. Whether an isolated malformation — like simple craniosynostosis — or part of a more complex multi-system genetic syndrome — like Apert syndrome — craniofacial issues require care that crosses traditional medical specialties and academic disciplines. To meet the range of needs presented by children with abnormalities of the head and neck, Seattle Children’s Craniofacial Center brings together 40 team members from 19 distinct disciplines (see box for complete listing). Rather than a loosely afп¬Ѓliated group of specialists that see the same patients on different days in different clinics, members of Children’s craniofacial team work together — and see patients together. Each child is assigned a core team that includes a pediatrician who oversees the child’s care as well as surgeons, dentists, orthodontists, nurses and social workers. A wealth of other specialists is available to help as needed. The team meets weekly to map out the best plan of care for each child on their panel and follows the child until age 21, or until the child graduates from the program. “Having a pediatrician coordinate care makes a difference,” says Dr. Michael Cunningham, the center’s medical director. “We take a holistic approach and care for the entire patient, not just the condition. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON That means caring for the medical and surgical needs of each child in the context of their family and community. “Our team members have different strengths, but shared goals. We all want to do what’s in the best interest of the child. When our team meets, everyone’s input counts. A patient may be scheduled for a surgery or a procedure, but if a social worker says вЂ�I don’t think this patient or family is ready,’ the plan is adjusted until it п¬Ѓts the family’s unique situation.” National peer organizations have praised the center as a model for addressing the interrelated medical, surgical and social issues presented by patients with craniofacial abnormalities. In 2005, the center named its п¬Ѓrst surgical director, Dr. Richard Hopper, in recognition of the critical integration of medical and surgical services needed to achieve the best outcomes for craniofacial patients. “We have created a unique, supportive environment within our clinic that responds to the needs of our patients,” Hopper says. “Our next challenge is to extend that customized support to the children while they are hospitalized during their operations and recovery.” The center is set to build on its successes. “With a large, dedicated team and the support of the hospital, we are in the enviable position of helping deп¬Ѓne the future care of children with craniofacial conditions,” Hopper says. Also in 2005, the Division of Craniofacial Medicine was created within the University of Washington’s Department of Pediatrics. Currently composed of pediatricians and basic scientists with expertise in genetics, epidemiology and developmental biology, the Division of Craniofacial Medicine is poised to make signiп¬Ѓcant research contributions in the п¬Ѓeld. This interdisciplinary division allows its members to address shared clinical and research challenges from different perspectives — in much the same way the Craniofacial Center functions, but on a larger scale. Already one of the busiest craniofacial programs in the nation, Seattle Children’s Craniofacial Center will double its clinical capacity in 2006. Of the more than 1,700 patients evaluated by the craniofacial team in 2005, 527 were new referrals. The craniofacial clinic saw an average of 70 patients each clinic day and registered nearly 9,000 patient visits last year, making it one of the busiest clinics at Seattle Children’s. The surgeons in the Craniofacial Center performed more than 1,500 surgical procedures in 2005. On the horizon is the Center for Craniofacial Research. The research is geared to answer several important questions: What are the molecular, genetic and environmental causes for the conditions we treat? What are the outcomes of the treatments we provide? What are the social and psychological ramiп¬Ѓcations of being a young child or teenager with a facial difference? This interdisciplinary approach to research will allow close working relationships needed by physicians and scientists to ask the most critical questions, while having the intellectual resources available to п¬Ѓnd important answers. The signiп¬Ѓcance of these answers is more than just academic. “Craniofacial conditions get right to the heart of a child’s identity,” Cunningham notes. “If you were asked to identify three photos — one of your hand, one of your shoulder and one of your face — you would undoubtedly reply вЂ�my hand,’ вЂ�my shoulder’ and вЂ�me.’ We treat what children will come to know as themselves.” RICHARD A. HOPPER, MD Titles Surgical Director, Seattle Children’s Craniofacial Center Craniomaxillofacial Plastic Surgeon, Seattle Children’s Hospital Associate Professor, Division of Plastic Surgery, University of Washington School of Medicine It Takes a Team Seattle Children’s Craniofacial Center has 40 team members from the following disciplines: Audiology Craniofacial Genetics Database Management Dental Medicine Genetic Epidemiology Neurosurgery Nursing Nutrition Occupational/Physical Therapy Ophthalmology Oral and Maxillofacial Surgery Otolaryngology Pediatrics Plastic and Reconstructive Surgery Pulmonology and Sleep Medicine Psychiatry Respiratory Home Care Social Work Speech Pathology SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 13 Transplant Transplant Getting to the Heart of Innovation GORDON A. COHEN, MD, PHD Titles Sam and Althea Stroum Endowed Chair in Pediatric Cardiovascular Surgery, Seattle Children’s Hospital Chief, Cardiothoracic Surgery and Co-director, Heart Center, Seattle Children’s Hospital Associate Professor, Department of Surgery, Division of Cardiothoracic Surgery, University of Washington School of Medicine 14 If you ask Dr. Gordon Cohen why he has dedicated his career to working with children who suffer from endstage heart failure, you’ll get a simple answer: it’s all about improving a child’s quality of life. Cohen co-directs Seattle Children’s Heart Center, which is rapidly becoming one of the most innovative clinical heart transplant programs in the United States and which sees some of the highest numbers of patients. While most pediatric transplant programs operate on older children, the average age of heart transplant patients at Seattle Children’s is 1 year, proof of the center’s ability to handle complex neonatal and infant transplants. In 2005, Cohen performed the п¬Ѓrst ABO-mismatched surgery in the Western United States. To date, he has successfully performed п¬Ѓve of these procedures, including one on a 13-day-old, 7.5-pound infant. This was the п¬Ѓrst neonate in the region bridged to transplant on ECMO, a mechanical cardiac assist device that Cohen uses aggressively for very high–risk patients. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Cohen is also innovating ways to support weakened hearts while they recover from transplant surgery. He is pioneering the use of an existing implantable ventricular assist device (VAD) for older children and developing a VAD for younger children. VADs offer the potential for children to recover at home after transplant. To date, no such device has been developed for children under 5 years of age. Cohen and his team modiп¬Ѓed a left VAD and demonstrated that they could provide total heart support to a patient with only one ventricle. Recently, Cohen listed a fetus for a donor heart after Children’s cardiologists Drs. Chris Steffanelli and Mark Lewin made an inutero diagnosis of a terminal heart condition. When a suitable match for a donor heart was found, the child was delivered via C-section — the п¬Ѓrst baby to be born at Seattle Children’s. Cohen and his surgical team went on to perform a successful ABOmismatched transplant several hours after the infant’s birth, another giant step forward for the Heart Center. Thinking Outside the Box “If it ain’t broke, don’t п¬Ѓx it,” is an old adage to which Dr. Jorge Reyes does not subscribe. “When we п¬Ѓnish a procedure and it’s perfect, that’s the time to reinvent it and do it again even better,” Reyes explains. Clearly, the man who has performed more than 200 multi-organ transplantations, including small intestine and liver, and more than 1,000 liver transplantations is never happy with the status quo. Reyes came to Seattle Children’s from Children’s Hospital of Pittsburgh in 2004 with a two-fold vision: to JORGE D. REYES, MD, FACS, FAAP Titles Director, Transplant Surgery, Seattle Children’s Hospital Chief, Department of Surgery, Division of Transplantation, University of Washington School of Medicine Director, Transplant Surgery, University of Washington Medical Center Transplant Service Line Editorships and Appointments Chair, Pediatric Transplantation Committee, United Network for Organ Sharing (UNOS) Member, Joint Membership Criteria Subcommittee, UNOS Member, Board of Directors, LifeCenter Northwest develop a pediatric intestinal care program and to make the existing liver transplant program — which already boasts some of the best outcomes in the country — the best in the nation. Helping give the very sickest children a second chance at life is the idea that drives Reyes to make this powerful vision a reality. That mission is shared by Dr. Simon Horslen, who joined Seattle Children’s in 2005 from University of Nebraska Medical Center in Omaha. Together, Reyes and Horslen have more combined experience treating intestinal and liver failure in children and teens than any other physician pair in the nation. SIMON P. HORSLEN, MBChB, FRCPCH Titles Medical Director, Liver and Intestine Transplantation Program, Seattle Children’s Hospital Professor, Department of Pediatrics, Division of Gastroenterology, University of Washington School of Medicine Editorships and Appointments Chair, Joint Pediatric Liver and Intestine Subcommittee, United Network for Organ Sharing (UNOS) Pediatric Transplantation Committee Member-at-Large, UNOS Liver and Intestine Transplantation Committee Member-at-Large, UNOS Joint Membership Criteria Subcommittee Member, UNOS Pediatric Symposium Organizer, American Association for the Study of Liver Diseases Co-chair, Education Committee, International Pediatric Transplant Association Post-graduate Course Organizer, International Pediatric Transplant Association Reyes trained with organ transplant pioneer Dr. Thomas Starzl, and was part of the team that pioneered intestinal transplant surgery. He has also been at the forefront of improving surgical techniques for split-liver and living-donor liver transplants. His clinical research program to reduce transplant patients’ dependence on immunosuppressive drug therapy will soon start up in Seattle. Here, Reyes brings new tools he developed in Pittsburgh that enable early diagnosis of post-operative infections. Horslen is one of the few physicians in the world with a breadth of experience in gastroenterology, hepatology, transplant and congenital metabolic disorders. Working in Great Britain, Australia and the United States, Horslen has gained a depth of experience treating patients with very rare intestinal and liver conditions. He is internationally recognized for his work to support intestinal function using non-surgical therapies — even when the children meet transplant criteria. Both physicians are strong advocates on the issue of access to organs for children. Ten years ago, Reyes realized that there were a signiп¬Ѓcant number of adults being transplanted with pediatric organs. He vowed to change this national policy, even speaking to Congress on the topic. Today, thanks to Reyes’ work, pediatric organs are allocated to children before being offered to adults. Horslen has made signiп¬Ѓcant contributions promoting equitable distribution of pediatric organs based on socioeconomic and geographic variables. Reyes and Horslen complement each other’s strengths as they bring new ways of thinking about transplant evaluation, surgical technique and post-transplant care to Seattle Children’s. “Getting the organ is a big deal, but keeping kids healthy postop requires creativity and constant vigilance,” Reyes says. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 15 General Pediatrics Safeguarding the Public’s Health FREDERICK P. RIVARA, MD, MPH Titles Vice-chair, Department of Pediatrics, University of Washington School of Medicine Division Head of General Pediatrics, Department of Pediatrics, University of Washington School of Medicine Adjunct Professor of Epidemiology, University of Washington School of Public Health Editorships and Appointments Editor, Archives of Pediatrics & Adolescent Medicine Deputy Editor, Injury Prevention Founding President, International Society for Child and Adolescent Injury Prevention Honors Elected to Institute of Medicine, 2005 16 The facts are sobering: injuries and trauma are the leading cause of death among children, teens and young adults. What’s more, almost half of all adult illness and death is caused by behaviors and disorders that begin in childhood. That’s why Dr. Frederick Rivara has committed his career to preventing avoidable injuries and diseases, safeguarding the health and wellbeing of children he will never meet. His recent election to the Institute of Medicine (IOM) of the National Academies recognizes his successes. “I became interested in the п¬Ѓeld of injury prevention almost out of frustration,” Rivara recalls. “I saw that there are limits to what doctors could do for sick or injured children and started wondering what we could do to prevent these things from happening in the п¬Ѓrst place.” Influencing public policy and the choices people make every day are his goals, and Rivara’s research has been instrumental in changing many of our cultural norms. He may be best known for his work to increase the use of bicycle helmets. When his research showed that bike helmets reduce the risk of head injury by 85 percent, Rivara worked to change laws and create effective interventions. Helmet usage increased from a meager 2 percent to 70 percent over a 10-year period. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON And the next time you ride in a car with someone younger than age 8, compare their seat to the one you rode in at that age. Rivara is studying the adult implications of childhood and adolescent behaviors such as smoking, drinking and violence, to see if intervening during childhood and adolescence can improve later health outcomes. As part of a team from the University of Washington and Johns Hopkins University, Rivara recently published a landmark, seven-year study illustrating the beneп¬Ѓts of regional centers in the treatment of trauma. Decreasing domestic violence — against children and partners — is also on Rivara’s agenda. As part of a study with Group Health Cooperative, a Northwest HMO, Rivara is evaluating the п¬Ѓnancial cost of domestic violence in terms of increased utilization of the health-care system. “Establishing the costs of unhealthy behaviors is a key to making change because it gets policy makers to take notice and invest in prevention and intervention,” Rivara says. He is realistic, however, about how quickly things change. “Behavior can change, but it takes time and isn’t easy. Many interventions fail because they aren’t maintained for enough time. It’s been 40 years since the Surgeon General said smoking is bad for health, but attitudes about smoking are п¬Ѓnally changing and it’s only now that it is illegal to smoke in public places.” Optimizing Technology to Improve Children’s Health A question began nagging Dr. Dimitri Christakis about eight years ago during his one-month stint as a stay-at-home dad. Observing his 3-month-old son riveted to the TV screen, Christakis wondered: how is the explosion of electronic media influencing the cognitive, emotional, behavioral and social development of young children? His work to answer that question has raised the national proп¬Ѓle on the multitude of issues surrounding media and children. His study linking early TV exposure with attention problems at age 7 has sparked a growing debate among parents, caregivers, academics and the media. He continues to publish regularly on the topic, including a 2005 report with colleague Michelle Garrison, MPH, that found no evidence that videos, DVDs and computer programs intended for young infants and toddlers and labeled “educational” had any educational value at all. But technology also holds great promise to improve the health of children, Christakis says. He is studying ways to use the Internet to improve families’ ability to care for their children. In 2005, he concluded a threeyear prevention study in which 2,000 families provided basic information about their demographics, health history and lifestyle. His team then tailored high-quality health information and sent it to the families, via the Internet, on a regular basis. The goals were to help parents understand the health issues and risks their families face and to encourage them to be more active partners during well-child visits. “When you take your child to a well-child visit, the doctor usually runs through the standard checklist of ageappropriate issues,” Christakis says. “We want parents to understand their family’s speciп¬Ѓc needs so they can help set the agenda with their doctor.” The study, which will be published later this year, found that the tailored information not only changed families’ experience during well-child visits, it resulted in behavioral changes within the home. Another study underway involves two groups of families with children between 18 months and 30 months of age. One group is receiving sets of blocks and monthly “blocktivities” that encourage children and parents to play together. The other group won’t receive the blocks and “blocktivities” until the study ends. Christakis hopes to discover whether the children who get the blocks experience an increase in language acquisition, cognitive skills and attention span — and a decrease in TV viewing. His research has uncovered a need for more work in this arena: This year, he will speak at three high-proп¬Ѓle conferences — hosted by the National Institutes of Health (NIH), the Centers DIMITRI A. CHRISTAKIS, MD Titles Director, Child Health Institute, University of Washington and Seattle Children’s Hospital Associate Professor, Department of Pediatrics, University of Washington School of Medicine Adjunct Associate Professor, University of Washington School of Public Health Editorships and Appointments Associate Editor, Pediatrics Associate Editor, Archives of Pediatrics & Adolescent Medicine for Disease Control (CDC) and the National Academy of Sciences — aimed at motivating more researchers to study media and child health. “We live in a media-rich environment. We’re inundated with it all the time. The question isn’t how to de-technologize children,” he says. “It’s how to help parents optimize technology to best serve the interests of their children.” SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 17 Infectious Disease and Immunology Fighting a Microbial War CRAIG E. RUBENS, MD, PHD Titles Children’s Hospital Guild Association Endowed Chair in Pediatric Infectious Disease Research Chief, Division of Infectious Diseases, Immunology and Rheumatology, Department of Pediatrics, University of Washington School of Medicine and Seattle Children’s Hospital Professor, Department of Pediatrics, University of Washington School of Medicine Adjunct Professor, Department of Microbiology, University of Washington School of Medicine Editorships and Appointments Editorial Advisory Board Member, Future Microbiology Member, American Society of Clinical Investigators Member, American Pediatrics Society 18 After 5-year-old Jake Finkbonner fell against a basketball pole while playing, the cut on his lip became infected with group A streptococci (GAS). Twentyfour hours later, Jake’s face and neck had swelled to more than twice its size as his small body attempted to п¬Ѓght this common bacterium. As the swelling progressed it became clear that the GAS had turned into a very serious infection — necrotizing fasciitis. After Jake was airlifted to Seattle Children’s, Dr. Craig Rubens coordinated aggressive treatment to stave off the life-threatening disease: several types of antibiotics, repeated surgeries and hyperbaric oxygen therapy. These treatments saved the kindergartner’s life, but not before the deadly bacteria severely damaged his scalp, face and chest. “Cases like Jake’s — when a virulent strain of common bacteria turns into a deadly disease — highlight the importance of studying microbes. These pathogens sometimes have the ability to quickly change, adapt and evolve at a much faster pace than the human immune system can п¬Ѓght them,” Rubens explains. In a 2005 study, Rubens and other scientists found that some bacteria might be tougher to characterize because their genome is always changing. The team tracked the genome of group B streptococci (GBS), and found that the bacteria are constantly evolving with as much as 30 percent of the gene content reshaping itself from one strain to the next. “This study helps us understand why some bacteria become drug-resistant. It also illuminates the challenges we face SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON in developing vaccines, because if the bacteria genes are always changing, the vaccines against GBS become ineffective,” Rubens says. GBS is a leading cause of newborn death in the United States. As many as 30 percent of pregnant women carry GBS and can unknowingly pass it on to their babies during birth. Rubens participated in shaping national CDC guidelines that require all clinicians practicing obstetric care to test women for GBS between 35 and 37 weeks of pregnancy. Because of these recommendations, the number of infants infected with the bacteria has decreased by 75 percent. Rubens is also helping the scientiп¬Ѓc community understand how GBS evades the body’s immune system, while other pathogens are more easily thwarted by the body’s innate diseaseп¬Ѓghting mechanisms. “GBS bacteria produce a sugar coating that acts like a protective shield. The immune system makes no effort to п¬Ѓght off these bacteria, because the body doesn’t recognize GBS as an invader,” Rubens says. He has identiп¬Ѓed factors produced by GBS bacteria and is working with drug developers to create a protein vaccine that stimulates antibodies in moms-to-be. The stimulated antibodies would then be transferred to the fetus via the mother’s bloodstream, preventing fetal infection during labor and delivery. Rubens has also identiп¬Ѓed another important connection in his war on germs. His perinatal studies show that GBS bacteria that have colonized the birth canal can eventually infect placental membranes, which can rupture the membranes and cause premature birth. Cracking the Code of Immunity Recent work to understand the human genome has made it possible to link immune system disorders to one of the body’s approximately 20,000 genes. To date, more than 130 different types of primary immunodeп¬Ѓciency disease (PIDD) have been identiп¬Ѓed, each caused by a different defect in a single gene. Dr. David Rawlings is one of the nation’s few physician-scientists identifying the molecular basis for many of these PIDDs and pioneering clinical therapies for children suffering from primary autoimmune diseases. After discovering that the “Btk” gene causes X-Linked agammaglobulinemia (XLA) — a PIDD that prevents young boys from producing immunoglobulins — Rawlings went to work on a gene therapy solution. After removing stem cells from mice, Rawlings used a retrovirus as a carrier to infect the cells’ chromosome with a normal copy of the Btk gene. Then he returned the stem cells to the mice. The mice used in Rawlings’ study developed B cells that made antibodies. “We’ve proven that gene therapy can overcome this disease in mice for the lifetime of the animal; now we’re working to make sure that the carrier virus is as safe as possible and has no other impact on human DNA before we begin clinical trials for patients suffering from XLA,” Rawlings says. His work has also led to the discovery of pathways in the body that control the survival and production of infection-п¬Ѓghting cells. In 2005, Rawlings identiп¬Ѓed a crucial trigger that activates a signaling pathway in T and B white blood cells, leading to the survival and growth of these cells. Normally, T and B cells work together with the immune system to make antibodies or to directly attack bacteria and viruses; however, over-activity of B cells causes many inflammatory and autoimmune diseases, and produces tumors in patients with lymphoma. “We have shown that this signaling pathway promotes the survival of normal B cells and we are now testing whether it also controls the growth and survival of some forms of B-cell lymphoma,” Rawlings explains. “We hope to identify classes of chemical agents that block activation of this pathway; eventually, our work may lead to the development of less toxic drugs that slow or stop the production of autoimmune or cancerous cells.” DAVID J. RAWLINGS, MD Titles Section Head, Division of Immunology, Seattle Children’s Hospital Professor, Department of Pediatrics, and Adjunct Professor, Department of Immunology, University of Washington School of Medicine Head, Immunodeficiency Clinical Program, Seattle Children’s Hospital Editorships and Appointments Editorial Advisory Board, Clinical Immunology Chair, XLA Patient Registry, USIDNET Member, American Association of Immunologists Section on Pediatric Rheumatology Member, American College of Rheumatology Member, American Society for Clinical Investigation Member, American Society for Gene Therapy Member, American Society of Hematology Member, Clinical Immunology Society Cellular and Molecular Immunology (CMI-A) Study Section Member, National Institutes of Health F R O M L E F T: Immunologist Dr. Andrew Scharenberg; infectious disease specialist Dr. Lisa Frankel SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 19 Urology Setting a Global Standard RICHARD W. GRADY, MD Titles Interim Chief, Division of Urology, Seattle Children’s Hospital Director, Clinical Research, Division of Urology, Seattle Children’s Hospital Director, Fellowship Program, Division of Urology, Seattle Children’s Hospital Associate Professor, Department of Urology, University of Washington School of Medicine Editorships and Appointments Executive Committee Member, Section of Pediatric Urology, American Association of Pediatrics Dr. Richard Grady is a busy man. When he’s not in the operating room treating complex urologic malformations, he’s traveling around the world — India, Korea, South Africa — training surgeons to perform the delicate bladder reconstruction techniques that put Seattle Children’s Division of Urology on the map. Grady carries on the legacy of Dr. Michael Mitchell, the Seattle Children’s urologist who discovered that if bladders with congenital defects are surgically repaired and allowed to empty and п¬Ѓll within the п¬Ѓrst few days of life, they will heal and develop normally. Grady helped pioneer complete primary exstrophy reconstruction in the United States. This singlestage surgical procedure on neonates corrects bladders that are exposed outside the body — a serious birth defect that used to require numerous reconstructive surgeries and left many children incontinent and suffering from chronic infections. Urologist Dr. Byron Joyner 20 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON In addition to forming reconstructions of the surgical type, Grady is also building a multi-platform research database that will help physician-scientists advance treatments for bladder exstrophy and other rare urologic disorders. The HIPAAcompliant database is the п¬Ѓrst of its kind in the п¬Ѓeld of urology, and will allow sharing of lab and radiology results as well as surgical and medical outcomes of patients from participating institutions around the world. “What used to take a lifetime of experience by a single physician or institution may be realized in just a few years with this multiinstitutional database,” Grady explains. “Collaborating with other clinicians today will establish standards of care so that young patients everywhere receive optimal care.” Dr. Michael Mitchell is internationally known for his work to correct urologic defects in children. Among his many contributions, Mitchell revolutionized surgical procedures for gastrocystoplasty and bladder exstrophy reconstruction. His surgical methods are now the standard of practice throughout the world. In 2004, Mitchell was awarded the American Urological Association’s Hugh Hampton Young Award for outstanding contributions to the study of genitourinary tract disease. Mitchell retired from Seattle Children’s in 2006 and moved to Wisconsin so he and his wife, Connie, could spend more time with their children and grandchildren; Mitchell works part time at Children’s Hospital of Wisconsin. Helping the Bladder Heal Itself Dr. James Bassuk has no shortage of human urothelial cells. These cells, which line the lower urinary tract, have an amazing ability to grow and divide in response to injury. In fact, in the span of two months, the cells he keeps frozen in his lab could proliferate and form a patch of bladder tissue big enough to cover a football п¬Ѓeld. Yet, Bassuk isn’t trying to grow a bladder. To date, getting blood vessels and nerves to grow in tissueengineered organs has proved problematic for scientists. Instead, this international expert on urothelial cells is proving that a patient’s own cells can be used to repair bladder damage caused by congenital defect, injury or illness. His visionary work is leading to the development of a cell-seeded “scaffold” that surgeons will be able to use in place of skin grafts to better treat conditions such as hypospadias — one of the most common birth defects in boys where the urethral opening forms on the underside of the penis. In 2002, Bassuk identiп¬Ѓed the human protein FGF-10, a growth factor that could have profound impact in bladder regeneration. Recently, he used experimental models to demonstrate that FGF-10 activates cell division in the lining of the lower urinary tract. Next, he will investigate whether FGF-10 repairs the urothelial lining in animal models when delivered locally through a catheter. “Being able to turn on urothelial cell proliferation in a controlled fashion is a major advance,” Bassuk says. “But we need to be able to turn it off as well.” Bassuk and his team created a “Super-SPARC,” a recombinant mutant human protein isolated from bacteria that can effectively shut down urothelial cell proliferation. The breakthrough of a combinatorial therapy of FGF-10 and SPARC will someday give clinicians the ability to better manage, and ultimately cure, a variety of urological afflictions such as interstitial cystitis, bladder cancer and urethral stricture — diseases where normal cell growth, differentiation and wound healing have gone wrong. JAMES A. BASSUK, PHD Titles Director, Human Urothelial Biology Program, Division of Urology, Seattle Children’s Hospital Associate Professor, Department of Urology, University of Washington School of Medicine SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 21 Nephrology Striking a Delicate Balance RUTH A. MCDONALD, MD Titles Medical Director, Solid Organ Transplantation, Seattle Children’s Hospital Co-director, Urology/Nephrology Outreach Clinics in Washington, Alaska and Montana, Seattle Children’s Hospital Associate Professor, Department of Pediatrics, Division of Nephrology, University of Washington School of Medicine Editorships and Appointments Board of Directors Member-at-Large, United Network for Organ Sharing (UNOS) Pediatric Transplantation Committee Member ex Officio, UNOS Kidney Allocation Review Subcommittee Member, UNOS Kidney-Pancreas Subcommittee Member, UNOS Pediatric Nephrology Sub-board Member, American Board of Pediatrics Board of Directors Member, North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) 22 In the mid-1990s, Dr. Ruth McDonald noticed a glaring disparity in the number of deceased-donor organs allocated to children and to adults. She vowed to develop a national organ allocation policy that would give the 600 children listed for a kidney an equitable chance when competing with the pool of 70,000 adults on the wait list. McDonald’s years of persistence paid off in September 2005 with a change in United Network for Organ Sharing (UNOS) policy. Children now go to near the top of the list for kidneys from deceased donors under the age of 35. This important policy change shortens a child’s transplant wait from years to months and decreases growth and development delays brought on by dialysis — a lifesaving treatment much better tolerated by adults than children. In 2006, McDonald was elected to a two-year term as an at-large member of the UNOS Board of Directors in recognition of her leadership and advocacy for pediatric renal transplant patients. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON In her clinical research and practice, McDonald strikes a delicate balance between immune suppression to prevent organ rejection and immune enhancement to п¬Ѓght viral attack. An active clinical researcher with a special interest in post-transplant lymphoproliferative disease, she leads Seattle Children’s involvement in two North American Pediatric Renal Trials and Collaborative Studies trials — multicenter pilots funded by the National Institutes of Health. In both studies she is investigating steroidfree immunosuppression for kidney transplant recipients. Early results indicate that patients have good graft outcome and improved growth without steroids. In her day-to-day clinical care, McDonald keeps patient- and graftsurvival outcomes far above the national average through close patient follow-up. As part of an aggressive viral surveillance protocol that she developed, McDonald modulates immunotherapy in response to active viral infection, which allows patients’ own immune systems to п¬Ѓght off viruses that cause malignancies and trigger organ rejection. Making the Scarring Stop More than 40 years after Dr. Bob Hickman founded the Division of Pediatric Nephrology at Seattle Children’s, Dr. Allison Eddy’s research on kidney п¬Ѓbrosis may lead to therapies that are every bit as revolutionary as the procedures performed with the original Hickman catheter. Eddy is one of only a few pediatric researchers in the world investigating basic pathogenetic mechanisms of chronic kidney disease, which has reached epidemic proportions worldwide. The goal of her basic science research program is simple: identify new ways to prevent the buildup of scar tissue that eventually causes kidneys to fail. Since discovering that a clotting protein, the molecule PAI-1, plays an important role in the renal scarring process, Eddy is now studying interventions that might halt the effects of PAI-1 in the kidney. Her п¬Ѓndings could have far-reaching implications, since PAI-1 and other members of this family of proteins may also promote scarring in other solid organs such as the heart, liver and lungs. Developing the next generation of nephrology specialists is another specialty of Eddy’s — and an important one, since half of all pediatric nephrologists in the United States will retire within a decade. Eddy oversees one of only six NIH-funded pediatrics fellowship programs in the country that trains pediatric nephrologists. Her program has enrolled 30 physician-scientists in the last 15 years, and offers both basic science and clinical research opportunities. Her goal is to mentor the best and brightest of these physician-scientists in the hope of expediting new treatments for childhood kidney failure. ALLISON A. EDDY, MD Titles Chief, Division of Nephrology, Seattle Children’s Hospital Director, Nephrology Fellowship Program, Seattle Children’s Hospital Professor, Department of Pediatrics, Division of Nephrology, University of Washington School of Medicine Co-director, Research Training Program in Pediatric Nephrology, NIH Training Grant Program Director, Child Health Research Center, University of Washington Editorships and Appointments Deputy Editor, Journal of the American Society of Nephrology Editorial Board Member, Pediatric Nephrology Drs. Allison Eddy and Ruth McDonald train the next generation of pediatric specialists. Need Photo for McDonald Dr. Sandra Watkins is director of clinical nephrology and co-director of the Clinical Research Center at Seattle Children’s Hospital, and professor of pediatrics at the University of Washington School of Medicine. She also serves as president of the American Society of Pediatric Nephrology. Watkins is one of the principal investigators for two NIH-funded studies looking at new therapies for focal segmental glomerulosclerosis and the causes in kidney failure due to infection with the 0157:H7 strain of E. coli. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 23 Fine-tuning Our Performance Continuously working to improve patient care The Campaign for Children’s — Fulfilling the Promise Seattle Children’s Hospital is in the midst of a bold fundraising campaign to advance our mission to prevent, treat and eliminate pediatric disease. The Campaign for Children’s — Fulfilling the Promise will raise $300 million and secure 1,200 legacy gift notifications for the following key areas of our work: Uncompensated Care Children’s was founded on the belief that all children deserve medical care that addresses their unique needs, regardless of their family’s ability to pay. Children’s provides some level of financial assistance to more than 60% of our patients, nearly $35.8 million in 2005. Research Research is the key to unlocking cures and discovering new treatments for diseases that affect children in our region and around the world. Facilities Family-friendly facilities with leading-edge technology and equipment help Children’s provide the best medical care and enhance our research capabilities. The Skinny on Our Efforts to Go Lean During the last several years, Seattle Children’s has undergone a major cultural shift by using Toyota Production System Principles — often referred to as lean processing — to increase patient safety, improve family satisfaction, streamline work flow and reduce costs. We call this effort Continuous Performance Improvement (CPI). 24 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Our faculty and staff — among the first health-care professionals in the nation to take advantage of Toyota’s lean principles — remove waste from our processes as a way to create more value for our patients while reducing barriers and obstacles for our people. Families are routinely involved in our “rapid process improvement” events. To date, our faculty and staff have participated in more than 80 improvement events, which last from three to five days and are designed to rapidly identify, test and implement improvements in all areas of a defined process. In-house facilitators encourage participants to try out ideas with the goal of improving our results by at least 50% by the end of the event. Afterwards, faculty and staff keep trying new improvements — a fundamental principle by which we continually enhance our systems and processes. “CPI helps us eliminate waste in its many forms and enables us to tap into the creativity and energy of our staff and families,” says Patrick Hagan, executive vice president and chief operating officer. Growing into the Future Seattle Children’s is growing. In a little more than two years, we’ve opened new facilities that improve our quality of care, enhance the family experience and expand our research capabilities. The Janet Sinegal Patient Care Building increased our inpatient capacity from 208 to 250 beds. The Melinda French Gates Ambulatory Care Building brings together more than 30 specialty outpatient clinics and diagnostic services in a 168,000-square-foot facility adjoining the hospital. Approximately 350 physician-scientists and staff researchers are now centrally located in downtown Seattle’s vibrant biotech community. Several leased floors in two buildings provide close to 100,000 square feet of laboratory, clinical and outcomes research space to facilitate teamwork and stimulate interdisciplinary investigations. Within the next decade, we plan to double the size of our emergency department and add regional ambulatory centers — all to keep pace with regional growth and rising numbers of patients. However, it is our commitment to preventing, treating and eliminating pediatric disease that has spawned our boldest vision — to quadruple our research facilities by adding 1 million square feet of space. It’s a lofty goal that will support a commitment worth keeping. An Ear for the Family Experience Nine and a half years ago when her infant daughter was first admitted to Seattle Children’s intensive care unit, Amy Jonas remembers that communication with clinicians was decidedly one-way. “I was told what would be done to my daughter,” she recalls. This year, nurses not only asked Jonas how she wanted to be involved in the care of her daughter, but the attending physician invited her to be a part of rounds. There, Jonas participated in a discussion about her daughter’s progress and gave input about the plan of care. Quality-of-care improvements like this one are the direct result of asking families about their experiences at Seattle Children’s and acting on their suggestions. Each year, nearly 7,000 of our families respond to a confidential Family Experience Survey that measures specific staff actions and practices. This rich source of feedback has served as the catalyst for much stronger family-provider partnerships and better teamwork between departments across the institution. Most important, the survey results give us insight into how our actions affect patients and families, helping us make the experience better for the next family. That’s the best reason we know for keeping our ears to the ground. Building Safety into Everything We Do Integral to our efforts to provide the best possible care is a rigorous emphasis on patient safety. We work actively and systematically to assess risks and prevent errors. Those who work most closely with our patients — our medical staff, nurses and support staff — identify vulnerabilities in our patient care processes and are trained to report them through a Web-based system we call eFeedbackNow. The majority of our eFeedbackNow reports are close calls — failures in the system that are caught before they reach the patient. This data directs our efforts to continuously build safety into everything that we do — and protect our patients from accidental injury while in our care. For example, we’ve drastically reduced total parenteral nutrition (TPN) errors by adding a dietitian and pharmacist to rounds on every inpatient service where TPN is prescribed. Shifting TPN prescriptive authority from residents to pharmacists reduced the number of corrections needed for a TPN order, improved communication between members of the care team and standardized TPN order flow while improving patient safety. Nearly 60 specialty clinics now enter orders, prescriptions, appointment requests and fee sheets online, eliminating lost or illegible orders and streamlining billing. Departmental “reminder” files are now a thing of the past, as orders and appointments submitted for a future date become part of the electronic record. At the end of each clinic appointment, busy families receive an electronically generated summary of their child’s visit — an easy way to remember all post-visit instructions. The system also reduces medication errors by flagging drug conflicts and dosing discrepancies. Moving more of our ambulatory information online is an important step forward in our evolution toward a completely electronic medical record. Not only does the new computerized system allow hospitalbased providers and referring physicians to view orders, diagnostic images, lab results, scheduling information and other details of their patients’ care anytime, from anywhere — it’s another way that we provide the safest care possible for our patients and families. Advancing Patient Safety with Information Technology In 2004, the New York Times and U.S.News & World Report hailed Seattle Children’s as a national leader in the medical use of information technology for successfully implementing a computerized provider orderentry (CPOE) system for inpatients. This year, we’ve implemented the same CPOE system in our outpatient clinics — a conversion that puts us ahead of the game in complying with national patient safety standards that prohibit verbal and telephone orders in all settings. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 25 Contents For your convenience, the Department and Division reports are identified by color bars on the outside of each page. Please refer to the color key on this page for help with locating the correct section. DEPARTMENT AND DIVISION REPORTS Anesthesiology and Pain Medicine 28-36 Craniofacial Center 37 Dental Medicine 38-42 Heart Center 43 Laboratory Medicine/Pathology 44-48 Neurology 49-53 Orthopedics 54-57 Pediatrics (Department of) 58 Adolescent Medicine 60-63 Cardiology 64-70 Craniofacial Medicine 71-75 Critical Care Medicine 76-80 Emergency Medicine 81-86 Endocrinology and Diabetes 87-89 Gastroenterology, Hepatology and Nutrition 90-94 General Pediatrics 95-110 Genetics and Developmental Medicine 111-123 Hematology/Oncology and Bone Marrow Transplant 124-136 Hospitalists 137-139 Infectious Disease, Immunology and Rheumatology 140-159 Neonatology 160-166 Nephrology 167-173 Pulmonary Medicine 174-182 Psychiatry and Behavioral Medicine 183-191 Radiology 192-196 Rehabilitation Medicine 197-199 26 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Surgery (Department of) 200 Cardiothoracic Surgery 202-203 Craniofacial, Plastic and Reconstructive Surgery 204-206 General and Thoracic Surgery 207-209 Neurosurgery 210-212 Ophthalmology 213-215 Oral and Maxillofacial Surgery 216 Otolaryngology 217-219 Transplant Surgery 220-224 Urology 225-228 Transplant Center 229 Research 230-237 Fellows and Residents 238-239 Financial Summary 240-241 Department and Division Reports SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 27 Anesthesiology and Pain Medicine The Department of Anesthesiology and Pain Medicine provides safe, family-friendly care for children before, during and after surgery. The pain medicine team also consults about, evaluates and treats children experiencing acute or chronic pain. Pain is an unpleasant sensory and emotional experience associated with actual and potential tissue damage. It is important to manage pain when treating a child: Inadequately controlled pain has undesirable effects on a child’s metabolic, physiological and emotional conditions. We are dedicated to improving infant, child and adolescent pain care and quality of life, and we provide our patients relief from a variety of afflictions, including pain related to surgical procedures, cancer, sickle cell disease and other conditions. Our team includes expert pediatric anesthesiologists, nurse anesthetists and nurse practitioners. Each has special experience and training with issues facing children during anesthesia. Before surgery, a nurse practitioner takes a complete medical history, including post-anesthetic experiences, and provides a complete physical exam. We provide information to the family on how children fall asleep under anesthesia. We also discuss the surgery center routine, recovery and criteria for home discharge. Our team includes attending physicians and advance practice nurses who provide pain management services 24 hours a day. TEACHING, RESEARCH AND CLINICAL EXPERTISE Lynn D. Martin, MD, is director of the Department of Anesthesiology and Pain Medicine at Seattle Children’s Hospital, and professor of anesthesiology and adjunct professor of pediatrics at the University of Washington School of Medicine. He received his MD from the University of Washington School of Medicine; he completed a pediatric residency at Phoenix Children’s Hospital and an anesthesia residency and a fellowship in pediatric anesthesia and critical care medicine at Johns Hopkins University. He is board certiп¬Ѓed by both the American Board of Anesthesiology and the American Board of Pediatrics with specialty certiп¬Ѓcation in pediatric critical care medicine. His research interests have involved conventional and nonconventional forms of mechanical ventilation in the OR and ICU. In addition, Dr. Martin has become involved in quality improvement and operative outcomes research. He is involved in the supervision of residents, fellows and CRNAs in the OR and ICU. Corrie T.M. Anderson, MD, is clinical director of the Pain Medicine Program for the Department of Anesthesiology and Pain Medicine at Seattle Children’s Hospital. He is also professor of anesthesiology and adjunct professor of pediatrics at the University of Washington 28 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON School of Medicine. Dr Anderson graduated from the Stanford University School of Medicine and completed a pediatrics residency and anesthesia fellowship at Children’s Hospital Boston; he did an anesthesia residency at Brigham and Women’s Hospital. He is board certiп¬Ѓed in pediatrics and anesthesiology, and holds a certiп¬Ѓcate in special competency in pain medicine. Dr. Anderson worked at the University of California, Los Angeles School of Medicine for 13 years. For the past two years, he has been listed as one of Seattle’s Best Doctors. Sanjay M. Bhananker, MBBS, MD, DA, is attending faculty anesthesiologist at Seattle Children’s Hospital, Harborview Medical Center and the University of Washington School of Medicine. He completed residencies in anesthesiology in India and the UK and a fellowship in pediatric anesthesiology in Ottawa, Canada. Dr. Bhananker is a clinician educator and plays a signiп¬Ѓcant role in the education of anesthesiology residents at the University of Washington. His research interests include pediatric trauma, pediatric burns and pediatric pharmacology. Dr. Bhananker has been active in regional, national and international anesthesiology societies, and has presented many topics at their meetings. Anesthesiology and Pain Medicine James C. Chen, MD, is acting assistant professor of anesthesiology at Seattle Children’s Hospital and at the University of Washington School of Medicine. He completed his residency in anesthesiology at Yale-New Haven Hospital and completed a fellowship in pediatric anesthesiology at Seattle Children’s. He is a member of the acute pain service at Seattle Children’s, and has an interest in QI data analysis for the service. He is board certiп¬Ѓed in anesthesiology, is active in intraoperative supervision and training of anesthesia residents and puts in time in the OR. Ursula Class, MD, is attending anesthesiologist at Seattle Children’s Hospital and is clinical assistant professor of anesthesiology at the University of Washington School of Medicine. She studied medicine at Eberhard-Karl University in Germany. She completed a pediatric residency at St. Louis Children’s Hospital and an anesthesia residency at Barnes Hospital, St Louis. She completed a pediatric anesthesia fellowship at Denver Children’s Hospital. Dr. Class served on the faculty at St. Louis Children’s Hospital. At Seattle Children’s, she participates in the supervision and training of anesthesia residents and fellows. Michael J. Eisses, MD, is attending anesthesiologist at Seattle Children’s Hospital in the Cardiac Anesthesia Program and assistant professor of anesthesia at the University of Washington School of Medicine. He earned his MD at the University of Washington and received the John J. Bonica Award for medical students. He did a residency in anesthesiology at the University of Washington, followed by a fellowship in pediatric anesthesia at Seattle Children’s; he completed a clinical fellowship and a one-year research fellowship in the Department of Laboratory Medicine. He is board certiп¬Ѓed in anesthesiology and is active in the FACULTY Lynn D. Martin MD, Director Lynn D. Martin, MD, Director Corrie T.M. Anderson, MD Sanjay M. Bhananker, MBBS, MD, DA James C. Chen, MD Ursula Class, MD Michael J. Eisses, MD Inge Falk van Rooyen, MBChB Sean H. Flack, MBChB Jeremy M.Geiduschek, MD supervision and training of anesthesia residents and fellows. His primary clinical responsibilities include providing anesthesia for neonates, infants and children undergoing procedures to treat congenital heart disease, and heart and liver transplants. He researches mechanisms and complications of coagulation and п¬Ѓbrinolytic activation as they relate to anesthesia and surgery, in particular cardiopulmonary bypass. He collaborates with the university departments of Laboratory Medicine and Bioengineering in constructing computer and kinetic models for hemostasis due to cardiopulmonary bypass in children. He received the B. Raymond Fink Research Award from the university in 2004. Inge Falk van Rooyen, MBChB, is attending anesthesiologist at Children’s Hospital and assistant professor in the Department of Anesthesiology at the University of Washington School of Medicine. She completed her anesthesia subspecialty training at the University of Cambridge in the UK. She is the lead clinician at Seattle Children’s for pediatric anesthesia for airway surgery. Dr Falk van Rooyen’s interests include management of the complex pediatric airway, development of safe sedation techniques and education within clinical anesthesia. As a member of the TEE writer group, she is part of the team of specialists that create exam practice questions for resident education. Her published works reflect her interest in airway surgery, respiratory pathology and physiology, and orthopedic and neurosurgery pediatric anesthesia. She has taught pediatric life support nationally, and directed courses locally; she is preceptor and mentor to medical students and anesthesia residents. She is an active member of the Washington State Society of Anesthesiologists, the American Society of Anesthesiologists and the Society for Pediatric Anesthesia. Charles M. Haberkern, MD, MPH Laurilyn D. Helmers, MD David S. Jardine, MD Nathalia Jimenez, MD, MPH Christer Jonmarker, MD, PhD Helen W. Karl, MD Anjana Kundu, MBBS, MD, DA Katie L. Larkin, MD Anne M. Lynn, MD Rosemary J. Orr, MBBCh Sally E. Rampersad, MB, DCH, FRCA Daniel D. Rubens, MBBS Edouard Saade, MD Nancy Setzer-Saade, MD Joshua C. Uffman, MD Karen Wong, MBBS SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 29 Anesthesiology and Pain Medicine Sean H. Flack, MBChB, is attending anesthesiologist at Seattle Children’s Hospital and acting assistant professor in the Department of Anesthesiology in the University of Washington School of Medicine. He completed his MB and anesthesiology residency at the University of Cape Town, South Africa. He completed his fellowship at the Royal United Hospital in Bath, UK, and returned to the Red Cross War Memorial Children’s Hospital in Cape Town. He is the lead anesthesiologist for general surgery at Seattle Children’s. Dr Flack’s clinical interests include regional anesthesia and the role of ultrasound in the practice of pediatric regional blocks. He has also developed an interest in anesthesia for awake craniotomy surgery. His laboratory research focuses on an animal model for the study of intrathecal drug distribution. Clinical research interests include the efп¬Ѓcacy of rectus sheath catheters for laparotomy pain, ultrasound-guided peripheral nerve blocks and the use of dexmedetomidine as an adjunct to general anesthesia. He has presented at a national level on a number of these topics. He is an active member of the Washington State Society of Anesthesiologists, the American Society of Anesthesiologists and the Society for Pediatric Anesthesia. Jeremy M. Geiduschek, MD, is clinical program director of clinical anesthesia services at Seattle Children’s Hospital and clinical professor in the Department of Anesthesiology at the University of Washington School of Medicine. He has been at Seattle Children’s since starting his internship in pediatrics in 1983. He completed a residency in anesthesiology and a one-year fellowship in pediatric anesthesiology. He did clinical research in Basel, Switzerland, on the effects of anesthesia on laryngeal mechanics in children. He is board certiп¬Ѓed in anesthesiology and participates in the supervision and training of anesthesia residents and fellows. Dr. Geiduschek has been active in establishing several clinical programs including the delivery of anesthesia to infants receiving ECMO, provision of anesthesia for children with cancer undergoing painful invasive procedures and use of ECMO in the repair of complete laryngtracheoesophageal п¬Ѓstula. Dr. Geiduschek was part of the group that established the national POCA (Pediatric Operative Cardiac Arrest) registry. He has been involved in improving operating room efп¬Ѓciency, patient safety and timely delivery of care. Dr. Geiduschek is an active member of the pediatric cardiac anesthesia team and has a strong clinical interest 30 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON in delivery of anesthesia for children with complex congenital heart disease. Charles M. Haberkern, MD, MPH, is staff anesthesiologist at Seattle Children’s Hospital and clinical professor of anesthesiology at the University of Washington. He is board certiп¬Ѓed in anesthesiology and is active in the supervision and training of anesthesia residents and fellows. He has worked at Seattle Children’s for the majority of years since he came to the hospital as an intern in pediatrics in 1974. He completed fellowship training in neonatology at the University of California, San Francisco, a residency in anesthesiology at the University of Florida, Gainesville, and a fellowship in pediatric anesthesia at Children’s Hospital Boston. He earned an MPH at Harvard University. Dr. Haberkern has been active in clinical care, resident and fellow education, operating room management and clinical research. He has maintained research interest in perioperative care of patients with sickle cell disease, health care services and the POCA (Pediatric Operative Cardiac Arrest) registry that is directed by the University of Washington. Laurilyn D. Helmers, MD, is attending anesthesiologist at Seattle Children’s Hospital and acting assistant professor in the Department of Anesthesiology and Pain Medicine at the University of Washington School of Medicine. She served as division director for pediatric anesthesia and as fellowship program director in the Department of Anesthesia at University of Iowa Hospitals and Clinics in Iowa City, Iowa. She is board certiп¬Ѓed in anesthesiology. She completed her internship in internal medicine at Good Samaritan Regional Medical Center in Phoenix and completed her anesthesia residency and pediatric anesthesia fellowship in Iowa City. In the clinical arena, Dr. Helmers is involved in the provision of anesthesia care to all pediatric age groups. She has an interest in acute pain management in the perioperative period, especially with the provision of regional anesthesia alternatives. Peripheral nerve blockade via single injections or catheters and the safety associated with these techniques are her special interests. In the academic arena, she is involved in teaching anesthesia residents and fellows and has an interest in incorporating alternative teaching methods into the current curriculum, especially in the subspecialty areas of pediatric anesthesia and regional anesthesia. Anesthesiology and Pain Medicine David S. Jardine, MD, is attending physician at Seattle Children’s Hospital and Harborview Medical Center, and associate professor of anesthesiology and pediatrics at the University of Washington Medical Center. He completed residencies in pediatrics and anesthesiology and a fellowship in pediatric anesthesiology and intensive care. He is board certiп¬Ѓed in anesthesiology and is active in the supervision and training of anesthesia residents and fellows. He has served as a reviewer for a variety of medical journals and has published widely, with an emphasis on hemorrhagic shock and encephalopathy syndrome. His laboratory interests are using heat shock proteins as biomarkers and examining the protective effect of heat shock proteins during brain injury. He has been principal investigator on several projects. Other interests include medical staffing issues; he helped formulate and interpret a recent American Academy of Pediatrics survey on pediatric intensive care stafп¬Ѓng. He serves on the Institutional Review Board at Seattle Children’s and on the research committee for the Department of Anesthesiology. He serves on the board of the SIDS Foundation of Washington and is incoming president for 2007. Nathalia Jimenez, MD, MPH, is attending physician at Seattle Children’s Hospital and acting assistant professor at the University of Washington School of Medicine. She completed her residency at Pontiп¬Ѓcia Universidad Javeriana in Colombia. She completed her fellowship in pediatric anesthesia at Seattle Children’s and earned an MPH in epidemiology at the University of Washington School of Public Health. As a fellow, she tested a new device for local anesthesia for IV cannulation in children that now is used routinely in clinical practice. As part of her MPH she worked at the injury prevention center helping educate Latino families about trafп¬Ѓc safety; in the American Society of Anesthesiologists Closed Claims Project, she evaluated trends in pediatric anesthesia liability. Her research interests include outcomes in anesthesia and ethnic differences in health services. Christer Jonmarker, MD, PhD, is director of the Cardiac Anesthesia Program at Seattle Children’s Hospital and associate professor at the University of Washington School of Medicine. He received residency training in surgery at Virginia Mason Hospital in Seattle, and in anesthesia and intensive care at the University Hospital in Lund, Sweden. He became a specialist in anesthesia and intensive care in Sweden in 1985 and completed a PhD thesis in respiratory physiology the same year. He was named docent at the University of Lund and was awarded the European Diploma of Anesthesiology. He served as director of pediatric anesthesia at the University Hospital in Lund. Dr Jonmarker’s primary interest is pediatric cardiac anesthesia and training. He has published articles on pediatric respiration and ventilation, circulation and clinical pharmacology. Helen W. Karl, MD, has been attending anesthesiologist at Seattle Children’s Hospital since 1990 and is associate professor of anesthesiology at the University of Washington School of Medicine. She received her MD from the University of Virginia School of Medicine. She completed an anesthesia residency at Hartford Hospital, Connecticut and completed a pediatric anesthesia fellowship at Children’s Hospital, Philadelphia. She is board certiп¬Ѓed in anesthesiology and participates in the supervision and training of the anesthesia residents and fellows. Anjana Kundu, MBBS, MD, DA, is director of the Complementary and Integrative Medicine Program and associate director of the Pediatric Pain Medicine Program at Seattle Children’s Hospital. She is assistant professor at the University of Washington School of Medicine. Dr. Kundu earned her MD and completed a residency program in anesthesiology in India. She completed her fellowship training in pediatric pain medicine and acupuncture training at Harvard Medical School and Children’s Hospital Boston. She completed a second residency in anesthesiology at Medical College of Wisconsin, Milwaukee. Her main areas of clinical and research interest include complementary and alternative medicine and pediatric pain medicine. Dr Kundu established the п¬Ѓrst formal clinical acupuncture service as part of the Complementary and Integrative Medicine Program at Seattle Children’s. She is board certiп¬Ѓed in anesthesiology and provides anesthesia for surgical procedures, radiological procedures, hematology and oncology services at University of Washington Medical Center. She served as co-director for a regional pediatric pain management conference and is developing a pediatric pain medicine fellowship at Seattle Children’s. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 31 Anesthesiology and Pain Medicine Katie L. Larkin, MD, is acting assistant professor in the Department of Anesthesia at the University of Washington School of Medicine. Dr. Larkin began her training in general surgery at Virginia Mason Medical Center in Seattle, and completed an anesthesia residency there. She did fellowships in pediatric anesthesia and pediatric pain management at Children’s Hospital Boston. She also attended Harvard Medical School’s course on acupuncture for physicians. She has an active clinical and teaching role on the acute pain service as well as seeing children in the outpatient Chronic Pain Clinic. She has a growing acupuncture practice. She has a strong clinical interest in palliative care and cancer pain management. She is board certiп¬Ѓed in anesthesiology and is active in the supervision and training of anesthesia residents and fellows. Anne M. Lynn, MD, is attending anesthesiologist at Seattle Children’s Hospital and professor of anesthesiology and adjunct professor of pediatrics at the University of Washington School of Medicine. She received her MD from Stanford University School of Medicine and did residencies in pediatrics and anesthesiology at the University of Washington. She completed a pediatric critical care fellowship at the Hospital for Sick Children in Toronto. She is board certiп¬Ѓed in anesthesiology and is active in the supervision and training of anesthesia residents and fellows. She has been treasurer, secretary, vice president and president of the Society for Pediatric Anesthesia, the largest pediatric anesthesia professional group in the US. She has been an active clinical investigator of pain management in infants with several studies of morphine use in postoperative infants. She is a pediatric section reviewer for Anesthesia and Analgesia. Dr. Lynn has been an active member of Seattle Children’s committees, including chairing the Pharmacy and Therapeutics Committee from 1996 to 2001. She has been listed in Seattle’s Best Doctors every year since 2001 and Best Doctors in America since 2003. Rosemary J. Orr, MBBCh, is associate professor at Seattle Children’s Hospital and the University of Washington School of Medicine. She is clinical director of sedation services for Seattle Children’s. Dr Orr received her MB from Queen’s University, Belfast, Northern Ireland and completed a pediatrics residency in Belfast. She completed a pediatrics residency at the University of Washington, a pediatric cardiology fellowship and two years as a neonatal biology fellow. She did an anesthesiology residency at the University of Washington and worked 32 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON in pediatric anesthesia at Children’s Hospital of Philadelphia. She joined the University of Washington as the п¬Ѓrst academic anesthesiologist working with the private practice of anesthesia at Seattle Children’s. She is board certiп¬Ѓed in pediatrics and anesthesiology, and she chairs Seattle Children’s Sedation Committee. She is a clinician and an educator, and her research has been clinically based. Recently she has studied several anesthetic drugs and anesthesia for airway procedures. Other research interests involve gathering data from anesthetics given for procedures outside the operating room. Sally E. Rampersad, MB, DCH, FRCA, is attending anesthesiologist at Seattle Children’s and assistant professor at the University of Washington School of Medicine. She earned her MB from the University of Southampton, England, and her DCH from the Royal College of Physicians of London. She trained in anesthesiology in the UK, becoming a fellow of the Royal College of Anaesthetists. She did a pediatric anesthesia fellowship at the Hospital for Sick Children in Toronto and worked as a visiting attending for two years at Seattle Children’s. She was a resident in anesthesiology at Virginia Mason Medical Center in Seattle. Her professional interests include pediatric anesthesia, regional anesthesia and improving error management in the operating room. She has served as an instructor for Pediatric Advanced Life Support in the US and Canada. She coordinates training for anesthesiology residents from the University of Washington and Virginia Mason Medical Center during their rotations at Seattle Children’s. Daniel D. Rubens, MBBS, is assistant professor of anesthesiology at Seattle Children’s Hospital and the University of Washington School of Medicine. Dr. Rubens also serves as director of medical simulation at Seattle Children’s. He earned his MBBS from the University of New South Wales, graduating with honors. He completed his anesthesia residency training at Liverpool Hospital, England, including rotations to Prince of Wales and Saint Vincent’s Hospitals for intensive care and pediatric retrieval training. Dr. Rubens is board certiп¬Ѓed in anesthesia and his primary teaching activities include supervising and training residents and fellows. He helped develop Simbaby, the world’s п¬Ѓrst infant simulator. He is researching the п¬Ѓnding of a hearing deп¬Ѓcit from inner ear damage, noted at birth in SIDS infants with newborn hearing tests, and its potential relationship to the later mechanism of death. Anesthesiology and Pain Medicine Edouard Saade MD, is an attending anesthesiologist and associate clinical professor of anesthesia at Seattle Children’s Hospital. Dr Saade completed his MD and residency training in anesthesia at McGill University and Montreal Children’s Hospital, Canada. He is board certiп¬Ѓed in anesthesiology and pain management and holds an MBA from Duke University. His previous clinical experience includes pediatric anesthesia and pain management at Miami Children’s Hospital and Driscoll Children’s Hospital. Dr. Saade is involved in all aspects of pediatric anesthetic care and is an active member of the cardiac anesthesia and liver transplant teams. at Liverpool Hospital in Sydney. She completed a fellowship at Princess Margaret Hospital for Children in Perth and worked as attending anesthesiologist at Sir Charles Gardiner Hospital in Perth. Dr Wong’s clinical interests include anesthesia for spinal surgery, sedation and simulator training. She has an active interest in anesthesia education and participates in oral board preparation for residents and fellows. She is also actively involved in the use of the simulator baby for the training of pediatric residents in anesthesia and emergency management of the sick child. Nancy Setzer-Saade MD, is educational director at Seattle Children’s Hospital. She earned her MD from the University of Miami School of Medicine and completed a pediatrics residency at Jackson Memorial Hospital/University of Miami. She completed a fellowship in pediatric critical care and a residency in anesthesiology at Johns Hopkins Hospital. Dr. Setzer served on the faculty at the University of Miami, where she established an accredited pediatric anesthesiology fellowship program. She serves as an associate examiner for the American Board of Anesthesiology and sits on the editorial board of the Self-Education and Evaluation Program, a continuing education tool of the American Society of Anesthesiologists. She is board certiп¬Ѓed in anesthesiology and is active in the supervision and training of anesthesia residents and fellows. AWARDS AND HONORS Joshua C. Uffman, MD, is attending anesthesiologist at Seattle Children’s Hospital and Harborview Medical Center and acting assistant professor at the University of Washington School of Medicine. Dr Uffman received his MD from Indiana University and completed an anesthesia residency at the University of Washington School of Medicine. He completed a pediatric anesthesia fellowship at Cincinnati Children’s Hospital. He is board certiп¬Ѓed in anesthesiology and is active in the supervision and training of anesthesia residents and fellows. Continuing Karen Wong, MBBS, is attending anesthesiologist at Seattle Children’s Hospital and acting assistant professor in the Department of Anesthesiology at the University of Washington School of Medicine. She is the lead anesthesiologist for spinal surgery at Seattle Children’s. She completed her MBBS at the University Melbourne, Australia, and an anesthesiology residency Corrie T.M. Anderson, MD Listed in “Best Doctors 2005,” Seattle magazine Nathalia Jimenez, MD, MPH Best scientiп¬Ѓc abstract for junior faculty, Academy of Pediatrics Section on Anesthesiology and Pain Medicine, 2005 Anne M. Lynn, MD Listed in “Best Doctors 2005,” Seattle magazine Listed in “Best Doctors in America,” 2005–2006 RESEARCH FUNDING Anne M. Lynn, MD Ketorolac in Surgical Infants: Pharmacokinetics/ Analgesia (IND 59883), Food & Drug Administration, $119,549 TEACHING AND PRESENTATIONS Corrie T.M. Anderson, MD Pediatric Pain – Past, Present and Future: How to Stop the Hurt (program chair and moderator), Seattle Children’s, 2005 Acute Pain Management in Children, Seattle Children’s, 2005 Neonatal Pain and Practical Pain Management, Seattle Children’s, 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 33 Anesthesiology and Pain Medicine Orientation to Pain Service, Seattle Children’s, 2005 Pediatric Sedation for Remote Locations, Seattle Children’s, 2005 Management of Tracheoesophageal Fistula, Seattle Children’s, 2005 Difп¬Ѓcult Airway Workshop, course director, National Medical Association, 2005 Postoperative Pulmonary Hypertension, Seattle Children’s and the University of Washington, 2005 Developmental Circulatory Physiology, Seattle Children’s and the University of Washington, 2005 James C. Chen, MD Alternative Therapies in Pediatric Pain, Seattle Children’s fellow pain topic review, February 2005 Anesthesia for Cardiac Catheterization in Pediatric Patients and Pediatric Anesthesia for Patients with Congenital Cardiac Conditions, Alberta Children’s Hospital, Calgary, Canada, November 2005 Michael J. Eisses, MD Coagulopathy and CPB, annual fellow lecture series, Seattle Children’s, 2005 Anne M. Lynn, MD Intraoperative Case Management, Seattle Children’s and the University of Washington, 2005 Consequences of CPB, annual fellow lecture series, Seattle Children’s, 2005 Induction Methods, Seattle Children’s and the University of Washington, 2005 Coagulation Problems Post-CPB: Problem-Based Learning, Society of Pediatric Anesthesia winter meeting, Miami, February 2005 Congenital Syndromes and Anesthesia Implications, Seattle Children’s and the University of Washington, 2005 Sean H. Flack, MBChB Journal Club, Department of Anesthesiology, Seattle Children’s, 2005 Pharmacology in Pediatrics, Seattle Children’s and the University of Washington, 2005 Pharmacology of Inhaled Agents and Neuromuscular Blockers, resident lecture, Seattle Children’s, 2005 Nathalia Jimenez, MD, MPH Statistics and Study Designs, anesthesiology department fellow lecture, Seattle Children’s, 2005 Induction Techniques, anesthesiology department fellow lecture, Seattle Children’s, 2005 Christer Jonmarker, MD, PhD Clinical Teaching in Pediatric Cardiac Anesthesia, Seattle Children’s and the University of Washington, 2005 An Overview of Congenital Heart Anomalies, Seattle Children’s and the University of Washington, 2005 34 Anesthesia for Non-Cardiac Surgery in Children with Congenital Heart Disease, Seattle Children’s and the University of Washington, 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Poster discussion, moderator, SPA winter meeting, Miami, February 2005 Lynn D. Martin, MD Society for Pediatric Anesthesia Winter Conference, invited faculty/workshop instructor, Miami, February 2005 Anesthesia and the URI; Neuromuscular Blocking Agents in Infants and Children; Developmental Respiratory Physiology; Transitional Circulation, Physiologic Mechanical Ventilation in Children; quarterly pediatric anesthesia core lecture series, University of Washington, 2005 Developmental Respiratory Physiology; Basics of Mechanical Ventilation, Transitional Circulation; and various topic reviews, annual fellow lecture series, University of Washington, 2005 Anesthesiology and Pain Medicine Developmental Respiratory Physiology; Basics of Mechanical Ventilation; Advanced Mechanical Ventilation; Experimental Cardiorespiratory Support; Essentials of Airway Management; and various topic reviews, biannual fellow lecture series, University of Washington, 2005 An Unsound Sleep: Anesthesia and URIs, Columbia University, New York, September 2005 Rosemary J. Orr, MBBCh Anesthesia for the Premature Infant, Seattle Children’s and the University of Washington, 2005 Anesthesia for Eye Surgery in Children, Seattle Children’s and the University of Washington, 2005 Anesthesia for Airway Surgery, Seattle Children’s and the University of Washington, 2005 Challenges of Remote Anesthesia, Seattle Children’s and the University of Washington, 2005 Extreme Difп¬Ѓculty with Ventilating the Lungs of a 7-Year-Old Surgical Patient (Protecting Patient Safety), PBLD presenter, ASA meeting, New Orleans, October 2005 Problem-Based Learning Discussion, presenter, ASA, Atlanta, October 2005 Sally E. Rampersad, MB, DCH, FRCA PALS and PBLD, Society for Pediatric Anesthesia winter meeting, February 2005 Visiting Professor, University of British Columbia, February 2005 Edouard Saade, MD CMEs, Pediatric Cardiac Intensive Care Society, 2005 Joshua C. Uffman, MD Capnography, Gas Analysis and Pulse Oximetry, Department of Anesthesiology resident lecture, University of Washington, 2005 Congenital Diaphragmatic Hernia, fellow lecture, Seattle Children’s, 2005 Muscular Dystrophies and Mitochondrial Myopathies, fellow lecture, Seattle Children’s, 2005 PUBLICATIONS Anand KJS, Aranda JV, Bende CB, Buckman S, Capperelli EV, Carol W, Hummel P, Johnston CC, Lantos J, Tutag-Lehr V, Lynn AM, Oberlander TF, Raju TNR, Maxwell LG, Soriano S, Taddio A, Walco GA. Analgesia and anesthesia for neonates: study design and ethical issues. Clin Ther. 2005;27:814–843. Berde CB, Jaksie T, Lynn AM. Anesthesia and analgesia during and after surgery in neonates. Clin Ther. 2005;27:900–921. Bhananker SM, O’Donnell JT, Salemi JR, Bishop MJ. The risk of anaphylactic reactions to rocuronium in the United States is comparable to that of vecuronium: an analysis of Food and Drug Administration reporting of adverse events. Anesth Analg. 2005;101(3):819–822. Blomquist S, Jonmarker C. Anesthesia for cardiothoracic surgery. Anestesi (Anesthesiology), 2nd edition. Stockholm, Sweden: Halldin and Lindahl, 2005 (in Swedish). Eisses MJ, Velan T, Aldea GS, Chandler WL. Strategies to reduce hemostatic activation during cardiopulmonary bypass. Thromb Res. 2005; e-publication. Goodwin SR, Haberkern CM, Crawford M, Lerman J, Mancuso T, Yaster M. Sickle cell and anesthesia: do not abandon well-established practices without evidence. Anesthes. 2005;103(1):205. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 35 Anesthesiology and Pain Medicine Jimenez N. Trends in pediatric anesthesia malpractice claims over the last three decades. ASA Newsletter. 2005;69(6):8–9,12. Morray JP, Bhananker SM. Recent п¬Ѓndings from the Pediatric Perioperative Cardiac Arrest (POCA) Registry. ASA Newsletter 6, 2005. Orr R. Anesthesia for microlaryngoscopy. Paediatr Anaesth. 5:81; author reply. 2005;81–82. Rampersad SE, Mulroy MF. A case of awareness despite an “adequate depth of anesthesia” as indicated by a Bispectral Index monitor. Anesth Analg. 2005;100:1363–1364. Rampersad SE, Lynn AM. Pediatric patient selection and provider issues. Ambul Surg. 2005;12:15–18. 36 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Craniofacial Center Children’s Craniofacial Center is one of the largest programs of its kind in the country and one of the busiest clinics in the hospital. It comprises an interdisciplinary team of 40 members from 19 specialty areas. Our team provides diagnosis and long-term management for children with complex craniofacial abnormalities. We treat all craniofacial conditions from the most common — cleft lip and palate and craniosynostosis — to the most rare Apert and Treacher Collins syndromes. The Craniofacial Center is organized to meet patients’ medical and surgical needs related to their condition, including breathing, feeding, sleeping, growth, hearing, vision and dental. We also offer prenatal counseling and a craniofacial genetics clinic. Surgical techniques developed by our craniofacial surgeons are revolutionizing the way craniofacial surgery is done all over the world. These innovative procedures enable doctors to address even the most serious and complex craniofacial abnormalities and provide the benefits of improved health and a more normal appearance for an increasing number of children. Our leadership team includes both a medical and a surgical director, which strengthens our ability to provide the highest-quality outcomes for our patients. FACULTY Michael L. Cunningham, MD, PhD, Medical Director of Children’s Craniofacial Center, Chief of the Division of Craniofacial Medicine (see also, Department of Pediatrics, Division of Craniofacial Medicine) Anthony M. Avellino, MD (see also, Department of Surgery, Division of Neurosurgery) Brent R. Collett, PhD (see also, Department of Psychiatry and Behavioral Medicine) Mark A. Egbert, DDS, Chief of the Division of Oral and Maxillofacial Surgery (see also, Department of Surgery, Division of Oral and Maxillofacial Surgery and Department of Dental Medicine) Richard G. Ellenbogen, MD, Chief of the Division of Neurosurgery (see also, Department of Surgery, Division of Neurosurgery) Ian A. Glass, MD, MBChB, Director of the Medical Genetics Program (see also, Department of Pediatrics, Division of Genetics and Developmental Medicine) Joseph S. Gruss, MD, Chief of the Division of Craniofacial, Plastic and Reconstructive Surgery (see also, Department of Surgery, Division of Craniofacial, Plastic and Reconstructive Surgery) Anne V. Hing, MD (see also, Department of Pediatrics, Division of Craniofacial Medicine and Division of Genetics and Developmental Medicine) Richard A. Hopper, MD, Surgical Director of Children’s Craniofacial Center (see also, Department of Surgery, Division of Craniofacial, Plastic and Reconstructive Surgery) Charlotte W. Lewis, MD, MPH (see also, Department of Pediatrics. Division of General Pediatrics) Wendy Mouradian, MD, MS (see also, Department of Pediatrics, Division of General Pediatrics) M. Lena Omnell, DDS, MSD, Chief of Orthodontics in the Department of Dental Medicine (see also, Department of Dental Medicine) Barbara L Sheller, DDS, MSD (see also, Department of Dental Medicine) Kathleen C.Y. Sie, MD (see also, Department of Surgery, Division of Otolaryngology) Dennis I Sipher, DDS (see also, Department of Dental Medicine) Matthew Speltz, PhD (see also, Department of Psychiatry and Behavioral Medicine) Jacqueline R. Starr, PhD, MS, MPH (see also, Department of Pediatrics, Division of Craniofacial Medicine) Avery H. Weiss, MD, Chief of the Division of Ophthalmology (see also, Department of Surgery, Division of Ophthalmology) Bryan Williams DDS, MSD, MEd, Director of the Department of Dental Medicine (see also, Department of Dental Medicine) Jonathan A. Perkins, DO (see also, Department of Surgery, Division of Otolaryngology) SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 37 Dental Medicine The Department of Dental Medicine addresses the dental needs of medically complex children and adolescents in the region up to age 17. We provide high-quality specialized dental care available only in the unique setting of a tertiary level pediatric medical center. The department’s professional staff have the expertise and the resources to render care to children referred from a variety of programs at Seattle Children’s Hospital; we’re most closely involved with the craniofacial, hematology/oncology, rheumatology, cardiology, rehabilitation medicine and neurodevelopment programs. The Department of Dental Medicine actively pursues clinical research, most often in collaboration with Seattle Children’s tertiary care programs, to further knowledge about diagnostic and treatment techniques and assure excellence in clinical care. The department participates in teaching future providers of pediatric medical and dental care, including integration with the teaching programs of the University of Washington, with a primary goal of assuring continued clinical excellence in the future care of children. The Department of Dental Medicine acts as a strong advocate for oral health on local, state and national levels. We feel that good oral health is critical to the well-being of the children in our society. TEACHING, RESEARCH AND CLINICAL EXPERTISE Bryan J. Williams DDS, MSD, MEd, is director of the Department of Dental Medicine at Seattle Children’s Hospital and staff orthodontist for the craniofacial team. He is afп¬Ѓliate professor at the University of Washington School of Dentistry in the departments of Pediatric Dentistry and Orthodontics. Dr. Williams received his dental training at the University of Western Ontario and received specialty training and an MEd at the University of Washington. He is a diplomate of both the American Board of Orthodontics and the American Board of Pediatric Dentistry. He lectures internationally on pediatric behavior management, emergency management, cleft palate, craniofacial anomalies and the care of children with complex medical and developmental problems. His professional interests include dental care for children with complex medical problems, management of dentoalveolar trauma and orthodontic management of children with cleft palate and other craniofacial anomalies. Jason Chang, DDS, is dental provider at the Odessa Brown Children’s Clinic in Seattle. Dr. Chang is a fulltime faculty member at the University of Washington School of Dentistry Department of Restorative Dentistry. Dr. Chang completed his dental training at the University of Detroit Mercy in 1999. He completed a 38 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON general practice residency at the University of Texas in San Antonio and an advanced dental practice residency at the University of Washington. He spends most of his clinical time at the Veterans Hospital in Seattle, where he specializes in advanced restorative techniques and dental materials. He is a member of the Academy of General Dentistry. Christopher Delecki DDS, MPH, MBA, is chief of the dental program at the Odessa Brown Children’s Clinic in Seattle. He is also a faculty member at the University of Washington School of Dentistry in the departments of Pediatric Dentistry and Restorative Dentistry. Dr. Delecki completed dental training and specialty training in public health at the University of Michigan. His received his MBA from City University in Bellevue, Washington. He served as commissioned ofп¬Ѓcer in the US Public Health Service, receiving more than 10 honors and awards including the Surgeon General’s Outstanding Service Medal. He has provided dental treatment, program management, consultation and preventive dental services on numerous Indian reservations throughout the Western US. His professional interests include preventive dental care and community-based oral health promotion and policy initiatives for children and families in Washington state. He is a member of the Washington State Oral Health Coalition and is working on assuring access to dental care for all children in Washington. Dental Medicine Mark A. Egbert, DDS, is Chief of the Division of Oral and Maxillofacial Surgery at Seattle Children’s Hospital and associate professor of OMS at the University of Washington School of Medicine. He served as chief of OMS trauma services and the Dental Department at Harborview Medical Center for 12 years. Dr. Egbert received his dental and OMS training at the University of Washington, and spent one year studying OMS at the Gemmente Ziekenhuis, Arnhem, The Netherlands. His particular interests include the biological basis of facial growth and development, the management of cleft lip and palate, applications of distraction osteogenesis in the correction of facial anomalies and the treatment of pediatric oral and maxillofacial pathology. Dr. Egbert serves on numerous review boards for journals, including the International Journal of Oral and Maxillofacial Surgery, the American Journal of OMS and Triple O. His professional society memberships include the AAOMS and ACPA, and he has served as president of the Western Society of OMS and the Washington State Society of OMS. He chairs and serves on committees of the American Association of OMS. He has served on the examining committee of the American Board of Oral and Maxillofacial Surgery. Geoffrey M. Greenlee, DDS, MSD, is attending dentist at the Odessa Brown Children’s Clinic, and clinical assistant professor in the University of Washington School of Dentistry Department of Orthodontics and a senior fellow in the Department of Dental Public Health Sciences. He is director of pre-doctoral orthodontics at the School of Dentistry. Dr. Greenlee completed dental school at the University of Michigan and received his MSD and certiп¬Ѓcate in orthodontics from the University of Washington. He completed a fellowship in cleft lip and palate and craniofacial anomalies at Seattle Children’s Hospital. FACULTY Bryan J. Williams DDS, MSD, MEd, Director Bryan J. Williams, DDS, MSD, MEd, Director Jason Chang, DDS Christopher Delecki, DDS, MPH, MBA, Mark A. Egbert, DDS Geoffrey M. Greenlee, DDS, MSD James A. Howard, DDS Lina Kim, DDS James A. Howard, DDS, is chief of Temporomandibular Joint Dysfunction in the Department of Dental Medicine at Seattle Children’s Hospital. Dr. Howard earned his DDS from the University of Washington School of Dentistry and did a special research and clinical fellowship in temporomandibular dysfunction at the university. Dr. Howard has a strong international reputation in the management of temporomandibular dysfunction. He has published numerous scientiп¬Ѓc papers and he lectures widely. In the pediatric population he is particularly interested in the management of temporomandibular function in children with juvenile rheumatoid arthritis. Lina Kim, DDS, is dental provider at the Odessa Brown Children’s Clinic in Seattle. She is a faculty member in the University of Washington School of Dentistry Department of Restorative Dentistry. Dr. Kim completed her dental training and a hospital-based general practice residency at the University of Washington. Her professional interests include providing compassionate and quality care to all of her patients while focusing on prevention. Cynthia L. Koudela, DDS, MSD, is pediatric orthodontist at Seattle Children’s Hospital and afп¬Ѓliate associate professor in the University of Washington School of Dentistry Department of Orthodontics. Dr. Koudela cares for children in the outpatient Dental Clinic and in the Craniofacial Center at Seattle Children’s. She received her DDS from the University of California, Los Angeles School of Dentistry and completed postdoctoral training in orthodontics at the University of Washington School of Dentistry. Dr. Koudela attended at Rhode Island Hospital in Providence and is a diplomate of the American Board of Orthodontics. She has expertise and training in craniofacial and surgical orthodontics and oral appliance treatment for obstructive sleep apnea. Cynthia L. Koudela, DDS, MSD Seok Bee Lim, DMD Speciп¬Ѓc areas of cliniJeffrey B. Marks, DDS cal and research interest M. Lena Omnell, DDS, MSD include nasoalveolar Andrea M. Pearson, DDS molding, nonsurgical Donna J. Quinby, DMD correction of congenital Mark M. Schubert, DDS, MSD Barbara L. Sheller, DDS, MSD auricular deformities Dennis I. Sipher, DDS and dental treatment for Terry M. Thomas, DDS obstructive sleep apnea. Lisa H. Zimberg, DMD SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 39 Dental Medicine Seok Bee Lim, DMD, is attending dentist at the Odessa Brown Children’s Clinic and on the clinical faculty at the University of Washington School of Dentistry Department of Pediatric Dentistry. Dr. Lim completed her dental training at Harvard School of Dental Medicine and did a hospital-based general practice residency at the University of Washington. She also has a management certiп¬Ѓcate from the university’s School of Business. Dr. Lim provides direct patient care, mentors residents and directs the dental program. Jeffrey B. Marks, DDS, is clinical assistant professor in the Department of Dental Medicine at Seattle Children’s Hospital and holds an afп¬Ѓliate faculty appointment in the University of Washington School of Dentistry Department of Pediatric Dentistry. Dr. Marks supervises postgraduate anesthesia and sedation training at the Odessa Brown Children’s Clinic. He served as a residency coordinator in the Division of Pediatric Dentistry at Primary Children’s Medical Center in Salt Lake City. Dr. Marks has lectured to many groups including the United States Turner Syndrome Society. He has submitted his research on the effects of myelomeningocele on intracranial structures to the Journal of Child Neurology and presented the results to the International Association of Dental Research. His current clinical and research interests include craniofacial anomalies, dental trauma and emergency care and anticipatory guidance for infants and toddlers. M. Lena Omnell, DDS, MSD, is chief of orthodontics at Seattle Children’s Hospital and afп¬Ѓliate professor in the University of Washington School of Dentistry Department of Orthodontics. She received dental and orthodontic specialty training in Lund/MalmГ¶, Sweden, and worked as regional chief orthodontist for nine years for the Trellborg District in Sweden. Dr. Omnell did research on growth and development at the National Institute of Dental Research in Bethesda, Md., and received her MSD in Washington state. She is involved in team care of children with craniofacial anomalies and provides orthodontic care to children at the Odessa Brown Children’s Clinic. Her main research interests are access to orthodontic care and growth and development in children with craniofacial anomalies. Dr. Omnell has presented at national and international meetings and authored and coauthored many articles in peer-reviewed publications on these topics. She has been involved in the Washington State Society of 40 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Orthodontists and serves on the review board for the American Journal of Orthodontics and Dentofacial Orthopedics and the Cleft Palate – Craniofacial Journal. Andrea M. Pearson, DDS, is a dentist at the Odessa Brown Children’s Clinic and afп¬Ѓliate faculty member at the University of Washington School of Dentistry. She graduated with honors from the University of the Paciп¬Ѓc dental school in San Francisco. She completed a general practice residency at the University of Washington and became certiп¬Ѓed in intravenous conscious sedation and advanced cardiac life support. Her clinical duties at Odessa Brown Children’s Clinic include infant, toddler, adolescent and teenager dentistry and dental resident supervision. Dr. Pearson is a member of the American Dental Association, Washington State Dental Association, Seattle King County Dental Society, American Academy of Cosmetic Dentistry and Academy of General Dentistry. She has published several articles in national newsletters advising predental students and has served on committees to help young dentists. Her interests in dentistry include pediatrics, oral surgery and sedation dentistry. Donna J. Quinby, DMD, is staff dentist at Seattle Children’s Hospital and afп¬Ѓliate clinical assistant professor in the University of Washington School of Dentistry Department of Pediatric Dentistry. Dr. Quinby graduated in dentistry from the College of Medicine and Dentistry, University of New Jersey and completed a hospital dental residency and a specialty training residency in pediatric dentistry at the University of Washington. Dr. Quinby has interests and expertise in the dental management of children with complex medical problems. She is a member of the regional hemophilia team. Mark M. Schubert, DDS, MSD, is attending dentist at Seattle Children’s Hospital and professor of oral medicine at the University of Washington School of Dentistry. He has an adjunct appointment in otolaryngology and head and neck surgery at the University of Washington Medical Center and is associate member in the clinical division at Fred Hutchinson Cancer Research Center. He is director of oral medicine at the Seattle Cancer Care Alliance and clinical director of the university undergraduate Dental Education for the Care of the Disabled Program. Dr. Schubert received his DDS from the University of Washington and completed a Dental Medicine hospital dental residency at the University Medical Center. He is a diplomate of the American Board of Oral Medicine and has published more than 85 articles and numerous book chapters on oral complications of cancer and cancer therapy. He was a founder of the International Society for Oral Oncology and has served as vice president and president. He is actively involved with the Multinational Association for Supportive Care in Cancer and is dental director for the Northwest AIDS Education and Training program. He has lectured internationally on oral cancer, HIV/ AIDS and general oral medicine. He has served on mucositis advisory boards and as principal investigator on mucositis research. Barbara L. Sheller, DDS, MSD, is chief of education and resident training at Seattle Children’s Hospital and afп¬Ѓliate professor in the University of Washington School of Dentistry Department of Pediatric Dentistry and Orthodontics. Dr. Sheller received her DDS and MSD in orthodontics from the University of Washington and a certiп¬Ѓcate in pediatric dentistry from Seattle Children’s Hospital. She practices pediatric dentistry and orthodontics at Seattle Children’s. She is diplomate of the American Board of Pediatric Dentistry and a reviewer for the journals Pediatric Dentistry, The Journal of Dentistry for Children, American Journal of Orthopedics and Dentofacial Orthopedics and Angle Orthodontist. Dr. Sheller serves on the Advisory Council of the American Board of Pediatric Dentistry and is a member of the Committee on Behavior Guidance for the AAPD Council of Clinical Affairs. Dennis I. Sipher, DDS, is pediatric dentist in the Department of Dental Medicine at Seattle Children’s Hospital. He is also acting assistant professor in the University of Washington School of Dentistry Department of Pediatric Dentistry. His clinical interests include sedation in pediatric dentistry and the dental management of children with ectodermal dysplasia. He is diplomate of the American Board of Pediatric Dentistry and past president of the Washington State Academy of Pediatric Dentistry. Terry M. Thomas, DDS, is chief of periodontics at Seattle Children’s Hospital. Dr. Thomas completed dental school at Loyola University Chicago, specialized in periodontics at Boston University and did an internship at the University of Washington Medical Center. He was an associate at Children’s Hospital in Denver. He is an active member in the Academy of Osseointegration, American Academy of Periodontology, American Dental Association and the Seattle King County Dental Society. Lisa H. Zimberg, DMD, is staff dentist at Seattle Children’s Hospital and instructor at the University of Washington School of Dentistry. She graduated from Boston University School of Dentistry and completed her residency at Columbia-Presbyterian Hospital in New York. She taught dental students and residents at Columbia College of Dentistry and Oral Surgery in New York. Dr. Zimberg is a member of the American Dental Association, Washington State Dental Association and Seattle King County Dental Society. AWARDS AND HONORS Christopher Delecki, DDS, MBA, MPH Seattle Best Dentist, January 2006 Geoffrey M. Greenlee, DDS, MSD T.M. Graber Teaching Fellowship Award, Orthodontic Faculty Development Award, American Association of Orthodontists Foundation, March 2006 TEACHING AND PRESENTATIONS Christopher Delecki, DDS, MBA, MPH Oral Health in the Primary Care Setting, presented to numerous medical provider groups, 2005 Geoffrey M. Greenlee, DDS, MSD Ethnicity in Malocclusion, Body Image, Treatment Expectations, Quality of Life, poster presentation, American Association for Dental Research 35th Annual Meeting & Exhibition, Orlando, Fla., March 11, 2006 Descriptive Analysis: Medicaid Population Recruited for an Orthodontic Prospective Clinical Trial, poster presentation, International Association for Dental Research 83rd General Session & Exhibition, Baltimore, March 12, 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 41 Dental Medicine M. Lena Omnell, DDS, MSD Descriptive Analysis: Medicaid Population Recruited for an Orthodontic Prospective Clinical Trial, poster presentation, International Association for Dental Research 83rd General Session & Exhibition, Baltimore, March 12, 2005 Barbara L. Sheller, DDS, MSD Dealing with Difп¬Ѓcult People, Women’s Interdisciplinary Study Group, Seattle, January 27, 2005 Behavior FUNdamentals for the Dental Team and Common Pediatric Medical Conditions: Impact on Dental Care, Charles A Sweet, Sr. Memorial Lecture, University of the Paciп¬Ѓc, San Francisco, May 7, 2005 Trauma, Special-Needs Patients, Behavior Management, Hospital Dentistry, Comprehensive Review of Pediatric Dentistry, American Academy of Pediatric Dentistry, Santa Monica, Calif., March 2005; Chicago, September 2005 Child Behavior in the Dental Ofп¬Ѓce: Professional Response in a Changing Climate, Western Society of Pediatric Dentistry annual meeting, Palm Springs, Calif., April 8–9, 2006 Bryan J. Williams, DDS, MSD, MEd Pediatric Behavior Management — What’s Fun and What Works! Internet Dental Forum, Juneau, Alaska, June 29, 2005 Oral Health in Primary Care Medicine, Inland Empire Primary Care Convention, Spokane, Wash., April 29, 2005 Visiting professor, Great Falls, Mont., August 2–3, 2005 42 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON PUBLICATIONS Lewis CW, Ose M, Aspinall C, Omnell ML. Community orthodontists and craniofacial care: Results of a Washington state survey. Cleft Palate Craniofac J. Sep 2005;42(5):521–525. PMID: 16149834 [PubMed - indexed for MEDLINE]. Rafferty KL, Sun Z, Egbert MA, Baird EE, Herring SW. Mandibular mechanics following osteotomy and appliance placement II: Bone strain on the body and condylar neck. J Oral Maxillofac Surg. Apr 2006;64(4): 620–627. Rafferty KL, Sun Z, Egbert MA, Herring SW. Mandibular mechanics after osteotomy and distraction appliance placement I: Postoperative mobility of the osteotomy site. J Oral Maxillofac Surg. Apr 2006;64(4): 610–619. Rowley ST, Sheller B, Williams BJ, Mancl L. Utilization of a hospital for treatment of pediatric dental emergencies. Pediatr Dent. 2006;28:10–17. Theis JE, Huang GJ, King GJ, Omnell ML. Eligibility for publicly funded orthodontic treatment determined by the handicapping labiolingual deviation index. Am J Orthod Dentofacial Orthop. Dec 2005;128(6):708–715. Woo A, Omnell ML, Williams B, Hopper R. Threedimensional midface stability following Lefort III distraction in syndromic pediatric patients (abstract). 63rd Annual Meeting Cleft Palate Craniofacial Association. 2006;108:67. Woo D, Sheller B, Williams B, Mancl L, Grembowski D. Dentists’ and parents’ perceptions of health, esthetics, and treatment of maxillary primary incisors. Pediatr Dent. 2005;27:19–23. Heart Center Seattle Children’s Heart Center is one of the nation’s most comprehensive cardiac programs. We provide comprehensive cardiac care for fetuses, infants, children and teens and assist with the transition of care into adulthood. Our specialized team includes pediatric cardiologists, cardiac surgeons, cardiac intensive care specialists, cardiac anesthesiologists, nurses, echocardiograph technicians and caring staff. We have a national reputation for excellence in a full range of cardiac services and procedures, from advanced catheterization for cardiac defects and heart rhythm disorders, to minimally invasive surgery for the simplest problems, to open heart surgical repairs and transplantation for infants with more complex cardiac problems. We are committed to the best possible outcome for each patient, with ongoing research into new treatments and technologies, ensuring that Children’s Heart Center will continue to provide state-of-the-art care to all children. FACULTY Harris P. Baden, MD (see also, Division of Critical Care Medicine) Robert J. Boucek Jr., MD, Co-director of Children’s Heart Center, Chief of Cardiology (see also, Department of Pediatrics, Division of Cardiology) Gordon A. Cohen, MD, PhD, Co-director of Children’s Heart Center, Chief of the Division of Cardiothoracic Surgery (see also, Department of Surgery, Division of Cardiothoracic Surgery) Terrence U. Chun, MD (see also, Department of Pediatrics, Division of Cardiology) Michelle Z. Gurvitz, MD (see also, Department of Pediatrics, Division of Cardiology) Bruce Hardy, MD (see also, Division of Cardiology) Howard E. Jeffries, MD, MPH, MBA (see also, Division of Critical Care Medicine) Troy A. Johnston, MD, Assistant Director of Cardiac Catheterization Laboratories (see also, Department of Pediatrics, Division of Cardiology) Thomas K. Jones, MD, Director of Cardiac Catheterization Laboratories (see also, Department of Pediatrics, Division of Cardiology) Isamu Kawabori, MD (see also, Department of Pediatrics, Division of Cardiology) Mark B. Lewin, MD, Director of Cardiac Ultrasound (see also, Department of Pediatrics, Division of Cardiology) Robert Mazor, MD (see also, Division of Critical Care Medicine) Amy H. Schultz, MD (see also, Department of Pediatrics, Division of Cardiology) Stanley J. Stamm, MD, Clinical Professor of Pediatrics, University of Washington J. Geoff Stevenson, MD, Director of Cardiac Ultrasound (see also, Department of Pediatrics, Division of Cardiology) Karen Stout, MD (see also, Department of Pediatrics, Division of Cardiology) Delphine Yung, MD (see also, Department of Pediatrics, Division of Cardiology Lester C. Permut, MD (see also, Department of Surgery, Division of Cardiothoracic Surgery) Michael A. Portman, MD, Director of Research (see also, Department of Pediatrics, Division of Cardiology) Jack C. Salerno, MD, Director of the Electrophysiology and Pacing Service (see also, Department of Pediatrics, Division of Cardiology) SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 43 Laboratory Medicine/Pathology The Department of Laboratory Medicine/Pathology is a comprehensive analytical facility serving outpatients, inpatients and regional programs and providing testing to more than 175 institutions in the country. In one year we have performed over 900,000 clinical laboratory tests, examined 6,000 surgical specimens, interpreted 600 bone marrow examinations, and performed 103 autopsies for perinatal and neonatal programs in the region and as part of quality control on medical care at Seattle Children’s Hospital. The laboratory is staffed by 10 University of Washington faculty members and more than 120 additional staff. In addition, the laboratory administers an extensive point-of-care testing program in the hospital and clinics, and for ground and air transport. Advanced instrumentation is interfaced to the electronic medical record, transferring information directly and minimizing input errors. All organ subspecialties are covered in anatomic pathology with a broad spectrum of techniques including histopathology, immunoproteomics and electron microscopy. Technicians complete diagnostic work-ups in a holistic fashion using in-house flow cytometry, cytogenetics, molecular cytogenetics and molecular pathology investigations. A strong analytical chemistry laboratory includes a regional biochemical genetics section. We continue to move microbiology work from conventional culture techniques to more sensitive and rapid molecular assays both for patient care and for research through the National Cystic Fibrosis Reference Microbiology Laboratory. TEACHING, RESEARCH AND CLINICAL EXPERTISE Joe C Rutledge, MD, is medical director of the Department of Laboratory Medicine/Pathology at Seattle Children’s Hospital and professor of laboratory medicine at the University of Washington School of Medicine. Dr. Rutledge participates in all aspects of the clinical laboratory but spends most of his time in the area of clinical pathology. His research interest in early mammalian development and teratology has been supplanted by research in the area of laboratory operations. He is former president of the Society for Pediatric Pathology and he and members of his department continue to have major leadership roles in that professional organization. He serves on the Pediatric Pathology Test Committee for the American Board of Pathology and is a consultant to the National Toxicology Program, the FDA and various medical centers in China. He is a member of many national organizations and serves on several editorial boards. Laura S. Finn, MD, is staff pathologist at Seattle Children’s Hospital and associate professor of pathology at the University of Washington School of Medicine. In addition to general surgical pathology, Dr. Finn has special expertise in pediatric renal pathology and is invited to speak at national meetings in that specialized 44 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON area. Dr. Finn has extensive background in solid organ transplantation pathology and serves as the liaison to transplant teams at Seattle Children’s. She directs the flow cytometry laboratory, which provides a wide range of diagnostic testing in immunodeп¬Ѓciencies and in hematopoietic tumors. She is the education coordinator for the Department of Laboratory Medicine/Pathology and directs the pediatric pathology fellowship program. Rhona M. Jack, PhD, is director of chemistry and codirector of the biochemical genetics lab at Seattle Children’s Hospital and clinical associate professor in laboratory medicine at the University of Washington School of Medicine. Dr. Jack’s teaching responsibilities include the university medical technology program, post doctoral clinical chemistry fellowship program and medical students. She is co-director of the clinical chemistry training program in laboratory medicine. Her clinical interests include newborn screening, diagnosis and follow-up of children with genetic metabolic diseases and lysosomal storage diseases. Raj P. Kapur, MD, PhD, is staff pathologist at Seattle Children’s Hospital and associate professor of pathology at the University of Washington School of Medicine. He is co-director of the fetal pathology service at Seattle Children’s, which serves as a diagnostic reference Laboratory Medicine/Pathology laboratory to multiple hospitals throughout Washington state. He has authored numerous papers related to pathology of the fetus and infant, and is an associate editor of a forthcoming text on this topic. Dr. Kapur is an international authority on the pathology of pediatric intestinal dysmotility and principal investigator for a research program related to murine models of Hirschsprung disease and other forms of intestinal pseudoobstruction. Dr. Kapur’s primary research interests involve the molecular and cellular events that underlie normal and abnormal development of the intestinal nervous system. His laboratory pioneered some of the п¬Ѓrst transgenic mouse models for manipulating gene expression in enteric neural precursors, and he and his colleagues continue these types of studies to elucidate when, where, and how the products of speciп¬Ѓc genes influence enteric neurodevelopment. Dr. Kapur is council member for the Society for Pediatric Pathology and associate editor for Pediatric and Developmental Pathology. interests in neuromuscular disorder, pediatric cardiovascular disease and pediatric tumors. Dr. Patterson serves as chair of the hospital Tissue Committee and serves as pathology representation on the Cancer Committee, for which she chairs a subcommittee overseeing the use of tissue for cancer research purposes. She also oversees the pathology aspects of the many ongoing Children’s Oncology Group (COG) research studies at Seattle Children’s and actively participates in the review of lung biopsy material with chILD, a national consortium studying interstitial lung disease in children. Her teaching activities at Children’s center on training University of Washington pathology residents and the Children’s pediatric pathology fellow. She is an active member of the Society of Pediatric Pathology; she chairs the Publications Committee, which oversees publication of the journal Pediatric and Developmental Pathology. Dr. Patterson is also interested in teaching pediatric pathology internationally, for which she has spent time in Bulgaria and Romania. Kent E. Opheim, PhD, is clinical cytogeneticist at Seattle Children’s Hospital and associate professor in the Department of Laboratory Medicine at the University of Washington School of Medicine. He is board certiп¬Ѓed in clinical chemistry and in clinical cytogenetics, and he is co-director of the clinical cytogenetics laboratory at Seattle Children’s. His clinical interests include molecular cytogenetic testing and translational research related to new molecular diagnostic testing, such as microarrays. Xuan Qin, PhD, is director of the microbiology laboratory at Seattle Children’s Hospital and assistant professor at the University of Washington School of Medicine. He serves as microbiology consultant to the core laboratory for cystic п¬Ѓbrosis microbiology, Cystic Fibrosis Therapeutic Development Network. He is a member of the faculty of the university postdoctoral training program in medical and public health laboratory microbiology and of Seattle Children’s Infection Control Committee. He is also microbiology laboratory advisor to the infectious disease fellowship program in the Department of Pediatrics at the University of Washington School of Medicine. His teaching and research interests include molecular diagnosis of infectious diseases, antimicrobial drug resistance and laboratory quality assurance. Kathleen Patterson, MD, is director of anatomic pathology at Seattle Children’s Hospital and associate professor at the University of Washington. Her clinical duties encompass the full range of anatomic pathology including surgical and autopsy pathology, with special FACULTY Joe C. Rutledge MD, Director Joe C. Rutledge, MD, Director Laura S. Finn, MD Rhona M. Jack, PhD Raj P. Kapur, MD, PhD Kent E. Opheim, PhD Kathleen Patterson, MD Xuan Qin, PhD Joseph R. Siebert, PhD Karen Tsuchiya, MD Min Xu, MD, PhD Joseph R. Siebert, PhD, is program director of autopsy services at Seattle Children’s Hospital. His chief clinical teaching responsibility is training pathology residents and fellows at autopsy, introducing them to a wide variety of fetal and pediatric autopsy techniques and relevant literature. This orientation may also involve laboratory and other technologists, medical students and pediatrics residents and fellows. His research interests center around congenital malformations, particularly of the craniofacial complex. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 45 Laboratory Medicine/Pathology Karen Tsuchiya, MD, is co-director of cytogenetics and molecular diagnostics at Seattle Children’s Hospital, assistant professor of laboratory medicine at the University of Washington School of Medicine, and staff scientist at the Fred Hutchinson Cancer Research Center. Her clinical interests include cytogenetics and molecular diagnostics of pediatric neoplasms. She is a member of the College of American Pathologists Cytogenetic Resource Committee. Dr. Tsuchiya’s primary research interest lies in the characterization of chromosome and molecular abnormalities in neoplasia. She is studying genomic abnormalities in mouse models of prostate cancer. Min Xu, MD, PhD, is staff clinical pathologist at Seattle Children’s Hospital and acting assistant professor at the University of Washington School of Medicine. She is board certiп¬Ѓed in clinical pathology. Her clinical interests include hematopathology, coagulation, chemistry and immunoassays. She serves as a voting member of the Pediatric Clinical Research Committee. RESEARCH FUNDING Continuing Raj P. Kapur, MD, PhD Sacral Crest Cells and Enteric Neurodevelopment, National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS, $208,600 TEACHING AND PRESENTATIONS Rhona M. Jack, PhD Measurement of Acid-Alpha Glucosidase in Lymphocytes for Diagnosis of Infantile Pompe Disease, Northwest Genetics Exchange, Vancouver, BC, Canada, May 2005 Raj P. Kapur, MD, PhD Autopsy Case Presentations, pediatric Grand Rounds, Seattle Children’s, January 14, 2005 Malignant Osteopetrosis, USCAP Pediatric Pathology Specialty Case Conference, USCAP annual meeting, San Antonio, Texas, February 27, 2005 46 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Genetic Disorders of Motility, International Symposium on Functional Gastrointestinal Disorders, Madison, Wis., April 8, 2005 Diagnostically Challenging or Unusual Placental Lesions, Washington State Society of Pathologists, Seattle, June 18, 2005 Molecular Genetics and Embryology of Congenital Intestinal Aganglionosis, general surgery lecture series, Seattle Children’s, August 18, 2005 Enteric Neuropathology, Frontiers in Gastroenterology and Hepatology, University of Washington, September 16, 2005 Xuan Qin, PhD Bordetella pertussis PCR: Simultaneous Targeting of Signature Sequences, Northwest Coastal Medical Microbiology Symposium, 2005 In Vitro Antimicrobial Susceptibility Testing MIC, MBC, and AUC, infectious diseases fellows lecture series, University of Washington, 2005 Antimicrobial Drug Resistance, Northwest Medical Laboratory Symposium, October 2005 Laboratory Accreditation and Quality Management, China Medical Board Program, SiCuan University School of Medicine, Chengdu, China, March 2005 Clinical Microbiology Laboratory Essentials: Structure, Personnel, and QA/QC, The Second Chinese American Association for Clinical Microbiology Symposium on the Advancement of the Clinical and Public Health Microbiology, Shanghai, China, September 2005 Visiting Professorship, Shanghai Public Health Center, Shanghai Fudan University, Shanghai, China, August 2005 Joseph R. Siebert, PhD Introduction to Fetal Pathology, Seattle Midwifery School, Seattle, March 2005 Fetal and Women’s Imaging 2005: OB-GYN Ultrasound Update, Seattle, September 2005 Laboratory Medicine/Pathology PUBLICATIONS Beaudoin D, Hagenzieker J, Jack RM. Neuronal ceroid-lipofuscinosis: what are the roles of electron microscopy, DNA, and enzyme analysis in diagnosis? J Histochemistry. Dec 2004;27(4):237–243. Bittles MA, Sidhu MK, Sze RW, Finn LS, Ghioni V, Perkins JA. Multidetector CT angiography of pediatric vascular malformations and hemangiomas: utility of 3-D reformatting in differential diagnosis. Pediatr Radiol. Nov 2005;35(11):1100–1106; e-publication, Jul 23, 2005. Bobola MS, Finn LS, Ellenbogen RG, Geyer JR, Berger MS, Braga JM, Meade EH, Gross ME, Silber JR. Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors. Clin Cancer Res. Oct 15, 2005;11(20):7405–7414. Chang A, Logar CM, Finn LS, Alpers CE, Seliger SL. A rare cause of necrotizing and crescentic glomerulonephritis in a young adult male. Am J Kidney Dis. May 2005;45(5):956–960. Crystal B, Gantt S, Qin X, Abe P, Zerr DM. Use of 16S rDNA PCR to identify Haemophilus influenzae type B as the etiology of pericarditis in an infant. Pediatr Infect Dis J. Mar 2005;24(3):287–288. Denno DM, Stapp JR, Booster DR, Qin X, Clausen CR, Delbacarro MI, Tarr PI. Etiology of pediatric diarrhea in outpatient settings. Pediatr Infect Dis J. Feb 2005;24(2):142–148. Doherty D, Glass IA, Siebert JR, Parisi MA, Shaw DWW, Chance PF, Barr M Jr, Nyberg D. Successful Joubert syndrome prenatal diagnosis by ultrasound, veriп¬Ѓed by fetal MRI and conп¬Ѓrmed by postmortem examination: implications. Prenat Diagn. 2005;25:442–447. Duthie MS, Kahn M, White M, Kapur RP, Kahn SJ. Critical proinflammatory and anti-inflammatory functions of different subsets CD1d-restricted natural killer T cells during Trypanosoma cruzi infection. Inf Immun. 2005;73:181–192. Duthie MS, Kahn M, White M, Kapur RP, Kahn SJ. Both CD1d antigen presentation and IL-12 are required to activate natural killer T cells during Trypanosoma cruzi infection. Inf Immun. 2005;73:1890–1894. Filippova GN, Cheng MK, Moore JM, Truong J-P, Hu YJ, Nguyen DK, Tsuchiya KD, Disteche CM. Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development. Develop Cell. 2005;8:31–42. Finn LS, Argenyi ZB. Congenital panfollicular nevus: report of a new entity. J Cutan Pathol. Jan 2005;32(1):59–62. Gilbert-Barness E, Oligny L, Kapur RP, Siebert JR, eds. Potter’s Pathology of the Fetus and Infant (second edition). In press. Kapur RP. Mendelian and complex diseases in gastroenterology and hepatology: multiple endocrine neoplasia type 2B and Hirschsprung disease. Clin Gastroenterol Hepatol. 2005;3:423–431. Kapur RP, Clarke CM, Doggett B, Taylor BE, Baldessari A, Parisi MA, Howe DG. Hox11L1 expression by precursors of enteric smooth muscle: an alternative explanation for megacecum in Hox11L1 -/- mice. Pediatr Dev Pathol. 2005;8:148–161. Li R, Johnson AB, Salomons G, Goldman JE, Naidu S, Quinlan R, Cree B, Ruyle SZ, Banwell B, D’Hooghe M, Siebert JR, Rolf CM, Cox H, Reddy A, GutiГ©rrezSolana LG, Collins A, Weller RO, Messing A, van der Knaap MS, Brenner M. GFAP mutations in infantile, juvenile and adult forms of Alexander disease. Ann Neurol. 2005;57:310–326. Loeb KR, Kostner H, Firpo E, Norwood T, Tsuchiya KD, Clurman BE, Roberts JM. A mouse model for cyclin E–dependent genetic instability and tumorigenesis. Cancer Cell. 2005;8(1):35–47. Manson J, Brabec MJ, Buelke-Sam J, Carlson GP, Chapin RE, Favor JB, Fischer LJ, Hattis D, Lees PSJ, Perreault-Darney S, Rutledge J, Smith TJ, Tice RR, Working P. NTP-CERHR expert panel on the reproductive and developmental toxicity of acrylamide. Birth Defect Research (Part B). 2005;74:17–113. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 47 Laboratory Medicine/Pathology Murray KF, Finn LS, Taylor SL, Seidel KD, Larson AM. Liver histology and alanine aminotransferase levels in children and adults with chronic hepatitis C infection. J Pediatr Gastroenterol Nutr. 2005 Nov;41(5):634–638. O’Sullivan J, Risques RA, Mendelson MH, Chen L, Brentnall TA, Bronner MD, MacMillan MP, Feng Z, Siebert JR, Potter JD, Rabinovitch PS. Telomere lengths in the colon decline with age: a relation to colorectal cancer? Cancer Epidemiology Biomarkers and Prevention. In press. Parisi MA, Lipman NS, Clarke CM, Taylor B, Kapur RP. Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudoobstruction. J Pediatr Surg. 2005;40:1760–1765. Phillips JJ, Mahony B, Siebert JR, Lalani T, Fligner C, Kapur R. Dandy-Walker malformation: correlation of diagnosis on prenatal ultrasound and on pathology review at autopsy. J Neuropath Exp Neurol. 2005;64:467. Qin X. Krugman’s Infectious Diseases of Children, 11th ed. (book review) Pediatr Dev Pathol. Feb;8(1):136. Qin X, Clausen CR, Stapp JR, Weissman SJ, Seidel KD. A temporal disc co-diffusion method detected piperacillin-tazobactam resistance in all Serratia marcescens isolates reportedly susceptible by conventional methods. J. Pediatr Infect Dis. 2006;1(1). Siebert JR. Current diagnosis and treatment in pulmonary disease [photographs]. Hanley M, Welsh C, eds. In press. Siebert JR. Erythropoietin neuroprotection in the term and preterm infant: safety and efп¬Ѓcacy (photographs). Demers EJ, Juul SE. In press. 48 Siebert JR. The perinatal, fetal, and embryonic autopsy. In: Potter’s Pathology of the Fetus and Infant (second edition). In press. Siebert JR: Review of Catalog of Teratogenic Agents (eleventh edition), by Thomas H. Shepard and Ronald J. Lemire. Ped Dev Pathol. 2005 8:402–403. Siebert JR. Review of Teratogenic Effects of Drugs: A Resource for Clinicians (TERIS) (second edition) by J.M. Friedman and Janine E. Polifka. Ped Dev Pathol. 2005;8:402–403. Siebert JR. Holoprosencephaly, anencephaly, kallman syndrome, Klippel Feil syndrome, Norrie disease, orofaciodigital syndrome, Yunis-Veradi syndrome, Miller Dieker – lissencephaly, subcortical band heterotopia, osteogenesis imperfecta - type II, reviews for Medlink CD-ROM and online information service for neurologists. Arbor Publishing Company, 2005. Siebert JR, Kapur RP. The back and perineum. In: Potter’s Pathology of the Fetus and Infant (second edition). In press. Siebert JR, Kapur RP, Resta RG, Luthy D. Methods for induced abortion (letter). Obstet Gynecol. 2005;105:221. Siebert JR, Rutledge JC, Kapur RP. The association of cloacal anomalies, caudal duplication, and twinning. Pediatr Dev Pathol. 2005;8:339–354. Siebert JR, Schoenecker K, Resta RG, Kapur RP. Holoprosencephaly and reduction limb defects: a consideration of Steinfeld syndrome and related conditions. Am J Med Genet. 2005;134A:381–392. Siebert JR. Medical genetics for the modern clinician: chromosomal abnormalities (photographs). Westman JA, ed. In press. Sinha AE, Hope JL, Prazen BJ, Nilsson EJ, Jack RM, Synovec RE. Algorithm for locating analytes of interest based on mass spectral similarity in GC x GC-TOF-MS data: analysis of metabolites in human infant urine. J Chrom. Nov 2005;1058:209–215. Siebert JR. Oro-facio-digital syndromes. In: Malformations of the Nervous System. Series Volume — Handbook of Clinical Neurology. Sarnat HB, Curatolo P, eds. Elsevier. In press. Spiller SE, Hawkins DS, Finn LS, Sze RW, Sybert V. Metastatic malignant melanoma presenting as pancytopenia in a three-year-old boy. Pediatr Blood Cancer. Jul 2005;45(1):60–63. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Neurology The Division of Neurology provides outpatient and inpatient consultation and management services for patients with a variety of neurologic, neuromuscular and neurodevelopmental disorders. Infants, children and adolescents with epilepsy, movement disorders, cerebral palsy, developmental delay, headache, muscular dystrophy, mitochondrial cytopathies and other disorders of the nervous system are evaluated by faculty pediatric neurologists who are certified by the American Board of Psychiatry and Neurology. Patients are also evaluated and managed by pediatric neurology mid-level providers (pediatric nurse practitioners and physician assistants). The clinical program is supported by pediatric neurology nurses, dietitians, neuropsychologists and social workers. The division operates regular clinics at Seattle Children’s Hospital and its regional satellites, and pediatric neurology providers participate in outreach programs in central Washington and Alaska. Faculty members provide inpatient consultation for patients admitted to Seattle Children’s and to the intensive care nursery at the University of Washington Medical Center. The division admits children to Seattle Children’s for evaluation of complex neurologic disorders and administers an inpatient video-EEG telemetry unit where children are admitted for intensive monitoring of epilepsy and other paroxysmal disorders. Together with the Division of Neurosurgery, the Division of Neurology operates a comprehensive pediatric epilepsy program. Management of children in the program may include epilepsy surgery, the ketogenic diet, use of the vagus nerve stimulator programs and participation in trials of new anticonvulsant medications. Children’s is the primary teaching site for the University of Washington residency training program in pediatric neurology, a nationally recognized program that has trained more than 30 practicing pediatric neurologists. The department has growing basic neuroscience and clinical research programs at Children’s and the university. Faculty research interests include the physiology of motor control, neural stem cell biology, basic cellular mechanisms of epileptogenesis, neurotoxicology, mitochondrial cytopathies, infantile spasms, pyridoxine-dependent seizures and risk factors of neonatal encephalopathy. TEACHING, RESEARCH AND CLINICAL EXPERTISE Sidney M. Gospe Jr., MD, PhD, is chief of the Division of Neurology at Seattle Children’s Hospital. Dr. Gospe is professor of neurology and pediatrics and holds the Herman and Faye Sarkowsky Endowed Chair in Child Neurology at the University of Washington School of Medicine. Dr. Gospe has been at Seattle Children’s FACULTY Sidney M. Gospe Jr., MD, PhD, Chief Nigel Bamford, MD Heidi Blume, MD, MPH Anthony Bouldin, MD Raymond Ferri, MD, PhD Laura A. Jansen, MD, PhD John Kuratani, MD Jerrold Milstein, MD, Emeritus Sidney M. Gospe Jr. MD, PhD, Chief since 2000, and previously was on the faculty at the University of California, Davis for 13 years. He received his MD and PhD from Duke University and trained in pediatrics and pediatric neurology at Baylor College of Medicine in Houston. Dr. Gospe’s clinical interests include general pediatric neurology and pediatric neuromuscular disorders. His research concerns the effects of maternal exposures to toxicants on the neurological development of their offspring, as well as the clinical and genetic Russell P. Saneto, DO, PhD aspects of pyridoxineHillary Shurtleff, PhD dependent seizures. Marcio Sotero de Menezes, MD Mary H. Warner, PhD At Children’s, he directs the division’s clinical and teaching programs, including the University of Washington residency training program in pediatric neurology. Dr. Gospe is a member of the American Board SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 49 Neurology of Pediatrics, an examiner for the American Board of Psychiatry and Neurology and a member of the editorial board of the journal Pediatric Neurology. Nigel Bamford, MD, is attending physician at Seattle Children’s Hospital and assistant professor of neurology and adjunct assistant professor of pediatrics at the University of Washington School of Medicine. Dr. Bamford treats patients with neurological disabilities and movement disorders at Seattle Children’s and seeks answers to their problems in the laboratory. Dr. Bamford’s research focuses on synaptic function and regulation of presynaptic activity in the mammalian basal ganglia. In the brain, the neostriatum plays an important role in cognition, voluntary movement and addiction. Evaluation of striatal function is paramount to understanding numerous developmental, neurological and psychiatric disorders, including substance abuse, juvenile Parkinson’s disease and Huntington disease. To gain insight into the mechanisms underlying a variety of neurodevelopmental and neurodegenerative disorders, Bamford and his colleagues use multiphoton microscopy, electrophysiology and other methods to observe the effects of dopamine on glutamate release in the striatum. Investigations focus on the function of the mammalian corticostriatal system (the collection of neurons that connect the cerebral cortex and striatum) and its role in motor disorders including dopamine depletion, the mechanisms of addiction and Huntington disease. In addition, pharmacological alternatives are being investigated for improved treatment. Heidi Blume, MD, MPH, is attending physician at Seattle Children’s Hospital and acting instructor in the Division of Pediatric Neurology at the University of Washington School of Medicine. She attended Harvard Medical School and completed residencies in general pediatrics and pediatric neurology at the University of Washington. She completed a research fellowship and earned an MPH in the Robert Wood Johnson Clinical Scholars Program at the University of Washington. Her primary research interests involve the epidemiology of childhood neurological disease, speciп¬Ѓcally neonatal and infantile neurological disorders. Anthony Bouldin, MD, is an active clinician in Seattle Children’s Hospital’s inpatient and outpatient neurology programs and also provides outreach clinics in Yakima and Wenatchee, Wash. He is clinical assistant professor in the Division of Pediatric Neurology at 50 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON the University of Washington School of Medicine. He received his MD from the University of Louisville and completed a pediatric residency at Tulane University. Dr. Bouldin completed pediatric neurology fellowship training at the University of Washington. His clinical interests include general pediatric neurology and neurogenetics. Raymond Ferri MD, PhD, is attending physician at Seattle Children’s Hospital and acting assistant professor of neurology at the University of Washington School of Medicine. His clinical interests are general child neurology and leukodystrophies — inherited, degenerative disorders of central nervous system myelin. Approximately half the children with abnormalities in white matter have no identiп¬Ѓable etiology. Dr. Ferri’s research program focuses on identifying factors that regulate the development of normal myelin. In particular, his lab is studying transcription factor regulation of oligodendrocyte differentiation and myelin maintenance. Dr. Ferri’s goal is to understand normal myelination and identify gene mutations that may result in abnormal myelination. In addition, these studies may identify targets for treatment of these disorders. Dr. Ferri is also involved in resident and medical student teaching. He supervises pediatric neurology residents in the continuity clinic, and teaches pediatric neurology residents, as well as adult neurology residents, pediatrics residents and medical students rotating on the pediatric neurology service. Laura A. Jansen, MD, PhD, is attending physician at Seattle Children’s Hospital. She received her MD and PhD from St. Louis University School of Medicine. She completed pediatrics and pediatric neurology residencies at the Washington University School of Medicine, St. Louis. She also did a research fellowship in the Department of Clinical and Experimental Epilepsy at University College London. Areas of clinical interest include general pediatric neurology, epilepsy and migraine. Her research activities include investigation of abnormalities in ion channel function in brain specimens from children treated surgically for intractable seizures, with the goals of identifying causes of pediatric epilepsy and optimizing medical treatment of seizures. John Kuratani, MD, is director of the pediatric EEG laboratory at Seattle Children’s Hospital and assistant professor of neurology and adjunct assistant professor Neurology of pediatrics at the University of Washington School of Medicine. His clinical interests include the management of infants, children and adolescents with epilepsy, clinical neurophysiology involving EEG, long-term monitoring and epilepsy surgery. His research interests include epilepsy surgery outcome and a collaborative project with colleagues from the Division of Neonatology on a treatment for perinatal asphyxia. He is actively involved in educating fellows, residents, medical students and EEG technologists on epilepsy and EEG interpretation. Russell P. Saneto, DO, PhD, is assistant professor of neurology and adjunct assistant professor of pediatrics at Seattle Children’s Hospital and the University of Washington School of Medicine. Dr Saneto received his DO from Des Moines University in Des Moines, Iowa and his PhD from the University of Texas Medical Branch in Galveston, Texas. He trained in pediatrics, pediatric neurology and pediatric epilepsy at the Cleveland Clinic in Cleveland, Ohio. Dr. Saneto’s clinical interests are in epilepsy, in particular difп¬Ѓcult-to-control epilepsy. He is involved in vagus nerve stimulation, the ketogenic diet and epilepsy surgery to control seizures. Dr. Saneto’s other interest is the diagnosis, treatment and care of patients with mitochondrial disease. He is particularly interested in patients with both mitochondrial disease and epilepsy. Dr. Saneto is board certiп¬Ѓed by the American Board of Pediatrics and American Board of Psychiatry and Neurology. He is also on the scientiп¬Ѓc board of advisors to the United Mitochondrial Disease Foundation and Northwest Epilepsy Foundation. Hillary Shurtleff, PhD, is clinical neuropsychologist at Seattle Children’s Hospital and clinical assistant professor in the Department of Neurology at the University of Washington Medical Center. She is board certiп¬Ѓed in clinical neuropsychology through the American Board of Professional Psychology’s American Board of Clinical Neuropsychology. She is a board member and past president of the Paciп¬Ѓc Northwest Neuropsychological Society, and a member of the Psychology Credentials and Peer Review Committee at Seattle Children’s. Her clinical, research and teaching interests include neuropsychological aspects of epilepsy and epilepsy surgery. Marcio Sotero de Menezes, MD, is co-director of the Epilepsy Center at Seattle Children’s Hospital and is associate professor of neurology and pediatrics at the University of Washington School of Medicine. His research interests include the outcome of epilepsy surgery in children; infantile spasms; epileptic spasms persisting beyond infancy; use of the ketogenic diet in treatment of seizures refractory to antiepileptic medications; use of vagus nerve stimulation in children, especially under age 12; alternatives for the current treatment of neonatal seizures; alternative therapies for the treatment of seizures; pharmacokinetics; and therapeutic options for absence epilepsy. He is an ad hoc reviewer for the journals Epilepsia and Pediatric Neurology. Mary H. Warner, PhD, is neuropsychologist at Seattle Children’s Hospital and clinical assistant professor in the Department of Neurology at the University of Washington Medical Center. She has worked in comprehensive epilepsy programs at Harborview Medical Center and at Swedish Medical Center in Seattle. Her principal interests are in the integration of the cognitive, social, emotional, educational and vocational aspects of epilepsy and other neurological disorders, with children, adolescents, adults and families. She has a particular interest in neuropsychological aspects of epilepsy surgery, including lateralization and localization of language functions in the brain. AWARDS AND HONORS Heidi Blume, MD, MPH Pediatric Academic Societies Travel Award Seattle Children’s Hospital Fellow’s Award Sidney M. Gospe Jr., MD, PhD Listed in “Best Doctors in America,” 2005 Laura A. Jansen, MD, PhD NIH National Institute of Neurological Disorders and Stroke Career Development Award John Kuratani, MD Best Teaching Award, Division of Pediatric Neurology, Department of Neurology, University of Washington SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 51 Neurology RESEARCH FUNDING New Laura A. Jansen, MD, PhD GABA-A Receptor Function in Pediatric Focal Cortical Dysp, National Institute of Neurological Disorders and Stroke/NIH/DHHS, $168,291 TEACHING AND PRESENTATIONS Nigel Bamford, MD Synaptic Plasticity in Neonatal Psychostimulant Withdrawal, North Paciп¬Ѓc Pediatric Neurology Colloquium, Seattle, May 2005 Presynaptic Regulation of Corticostriatal Terminals by Acetylcholine Unveiled During Amphetamine Withdrawal, Gordon Research Conference, Proctor Academy, N.H., July 2005 Chronic Methamphetamine Mediates Long-Term Depression of Corticostriatal Release in the Dorsal Striatum, Child Neurology Society annual meeting, Los Angeles, September 2005 Heidi Blume, MD, MPH Fever, Chorioamnionitis and Neonatal Encephalopathy, PAS, platform presentation/abstract, May 2005 Neonatal Encephalopathy and Socioeconomic Status: A Population-Based Case-Control Study, Child Neurology Society abstract, poster presentation/abstract, October 2005 Developmental Anomalies of the Central Nervous System, Resident Didactic Conference, Seattle Children’s, 2005 Raymond Ferri MD, PhD Childhood Epilepsy, Kindering Center Birth-3 Program, Belleuve, Wash., January 2005 Diagnosis of Metabolic Disorders, Harborview Neurology Resident Teaching Conference, Seattle, February 2005 Sidney M. Gospe Jr., MD, PhD Update on Pyridoxine-Dependent Seizures, neurology Grand Rounds, University of Washington, 2005 52 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Update on Neurocutaneous Disorders, and Differential Diagnosis of Hypotonia, visiting professor program, Pocatello and Boise, Idaho, October 2005 Laura A. Jansen, MD, PhD GABA-A Receptor Function in Pediatric Epilepsy, Paciп¬Ѓc Northwest and Western Canada Pediatric Neurology Colloquium, Vancouver, BC, Canada, May 2005 Ataxia, Pediatric Resident Conference, Seattle Children’s, October 2005 John Kuratani, MD Outpatient Epilepsy: Diagnostic and Management Issues About Seizures for the Primary Care Physician, visiting professor program, Yakima and Toppenish, Wash., April 2005 Update on Seizure Management, visiting professor program, Bellingham, Wash., May 2005 Russell P. Saneto, DO, PhD Mitochondrial Disease: A Primer and Rational Treatment for Mitochondrial Disease, International College of Integrative Medicine 43rd annual meeting, Phoenix, March 2005 Management Strategy for Acute Illness in Patients with Mitochondrial Disease, Ask the Mito Doc Panel (panel member), Mitochondrial Medicine Annual Symposium, St. Louis, 2005 Marcio Sotero de Menezes, MD Absence Seizures and Absence Epilepsy Syndromes, Pediatric Neurology Conference, Seattle Children’s, February 2005 Hypotonia in Neonates and Infants, Neurology Conference, Harborview Medical Center Seattle, March 2005 AEDs in Pediatric Epilepsy, Pediatric Neurology Conference, Seattle Children’s, June 2005 Pediatric Epilepsy Syndromes, neurology Grand Rounds, University of Washington, July 2005 Infantile Spasms, Madigan Hospital neurology course, Tacoma, Wash., November 2005 Neurology PUBLICATIONS Allan WC, Gospe SM. Seizures, syncope or breathholding presenting to the pediatric neurologist — when is the etiology a life-threatening arrhythmia? Semin Pediatr Neurol. 2005;12:2–9. Bamford NS, Joyce JA. Chronic methamphetamine mediates long-term depression of corticostriatal release in the dorsal striatum. Ann Neurol. 2005;58(S9):S81. Bamford NS, Singh N, Erbe JK, Joyce JA. Activation of striatal cholinergic neurons mediates long-term depression of corticostriatal release during methamphetamine withdrawal. Society for Neuroscience Abstracts. 2005;1030:11. Bennett CL, Huynh HM, Chance PF, Glass IA, Gospe SM. Genetic heterogeneity for autosomal recessive pyridoxine-dependent seizures. Neurogenetics. 2005;6:143–149. Everett L, Von Rooyen IF, Warner MH, Shurtleff H, Saneto RP, Ojemann, J. Use of dexmedetomidine in awake craniotomy in adolescence: report of two cases. Pediatric Anesth. 2005. Ferri R, Chance P. Lorenzo’s oil: advances in the treatment of neurometabolic disorders. Arch Neurol. Jul 2005;62(7):1045–1046. Gospe SM, Bell RMS. Hospital pharmacy and emergency department availability of parenteral pyridoxine. Ped Emerg Care. 2005;9:586–588. Gospe SM, Camп¬Ѓeld P. Cardiac causes of sudden death: virtual panel discussion of posed questions. Semin Pediatr Neurol. 2005;12:67–69. Gurnett CA, Dobbs MB, Jansen LA, Bowcock AM. Identiп¬Ѓcation of a locus for complex febrile seizures on chromosome 12q22-q23.3 in a North American family. Epilepsia 2005;46(s8):367–368. Jansen LA, Uhlmann EJ, Crino PB, Gutmann DH, Wong M. Epileptogenesis and reduced inward rectiп¬Ѓer potassium current in tuberous sclerosis complex-1-deп¬Ѓcient astrocytes. Epilepsia. 2005;46(12):1871–1880. Ouyang Y, Gazit V, Jansen LA, Ess KC, Yamada KA, Gutmann DH, Wong M. Impaired long-term potentiation and excitotoxic cell death in an animal model of tuberous sclerosis complex. Epilepsia 2005;46(s8):14. Saneto RP, Sotero de Menezes MA, Ojemann J, Bournival B, Murphy P, Cook WB, Avellino A, Ellenbogen R. Vagus nerve stimulation therapy for medically intractable seizures in children under 12 years of age. Epilepsia. 2005;46(8):229(suppl). Saneto RP. Unverricht-Lundborg disease for professionals. The Epilepsy Project’s Web site program. 2005;e-publication. Saneto RP. Unverricht-Lundborg disease. The Epilepsy Project’s Web site program. 2005; e-publication. Smyth MD, Ojemann JG, Zempel J, Robinson S, O’Brien DF, Saneto RP, Goyal M, Appleton RE, Park TS. Surgical outcomes for temporal lobe epilepsy in young children: A multi-institution analysis. Epilepsia. 2005;46(8):158 (suppl). Sotero de Menezes M. Ketogenic diet. MedLink. June 2005; Neurobase CD-ROM and online book. Sotero de Menezes M. Hypoxic-ischemic encephalopathy. E-medicine — Neurology; eMedicine Journal, 2005. Sotero de Menezes M. Status epilepticus. E-medicine — Pediatrics; eMedicine Journal, June 2005. Zerr DM, Blume HK, Berg AT, Del Beccaro MA, Gospe SM, Allpress AL, Christakis DA. Nonfebrile illness seizures: a unique seizure category? Epilepsia. 2005;46:952–955. Holmes MD, Tucker DM, Brown M, Saneto RP, Ojemann JG. Intracranial conп¬Ѓrmation of dense array EEG localization of extratemporal seizure onset and propagation. Epilepsia. 2005;46(8):142(suppl). SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 53 Orthopedics The Department of Orthopedics specializes in providing the highest-quality pediatric care based on clinic research. We provide a full spectrum of clinical care at Seattle Children’s Hospital and locations in Bellevue, Olympia and Everett, Wash. as well as outreach facilities in Yakima, Wenatchee and the Tri-Cities in Washington and in Anchorage, Alaska. Our faculty includes some of the most accomplished pediatric orthopedic surgeons in North America completely dedicated to providing immediate access and care to the children of our region. We treat fractures and pediatric trauma, spinal deformities, pediatric foot deformities including clubfoot, sports injuries and musculoskeletal tumors (malignant and benign) and infections (acute and chronic). We collaborate on treating neuromuscular disorders, including cerebral palsy and myelomeningocele; scoliosis, kyphosis and pediatric spine deformities including idiopathic and congenital deformities; and skeletal dysplasia, including achondroplasia. We specialize in pediatric hand disorders, correcting limb length discrepancy with Illizarov reconstruction techniques and pediatric hip disease, including Legg-CalvГ©-Perthes disease and slipped capital femoral epiphysis. We also practice sports medicine for children and adolescents. Our research and education provide the foundation for improving care to all of our patients. TEACHING, RESEARCH AND CLINICAL EXPERTISE Ernest U. Conrad III, MD, is director of the Department of Orthopedics at Seattle Children’s Hospital and professor of orthopedic surgery at the University of Washington School of Medicine. He completed training at the Hospital of Special Surgery in New York, a musculoskeletal tumor fellowship at the University of Florida and a pediatric orthopedic fellowship in Toronto. When he joined the Department of Orthopedics, he instituted the Division of Musculoskeletal Oncology and Transplantation and multidisciplinary clinics at the University of Washington for sarcoma and bone tumor. He directed the Division of Orthopedic Surgery at the university and serves as medical director at the Northwest Tissue Center, a regional nonproп¬Ѓt tissue center in Seattle. Dr. Conrad’s research includes multiple clinical studies in pediatric and adult tumors with a special interest in pediatric limb-sparing procedures, benign pediatric tumors and soft-tissue sarcomas in adults. His research interests include the metabolic imaging of sarcomas with the use of PET scans and the biologic responses associated with musculoskeletal transplantation. 54 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Michael J. Goldberg, MD, is consulting orthopedic surgeon at Seattle Children’s Hospital and clinical professor in the Department of Orthopedics at the University of Washington School of Medicine. He was chairman of the Department of Orthopedics at Tufts University School of Medicine and Tufts-New England Medical Center, Boston. His clinical interests include skeletal dysplasias and orthopedic syndromes. Clinics focused on bone dysplasias and orthopedic syndromes are held at Seattle Children’s and in Bellevue, Wash. Outreach clinics in general pediatric orthopedics take place in Bellevue, Olympia and Federal Way, Wash. Dr. Goldberg’s research activities include orthopedic aspects of syndromes, and measuring the outcomes and functional health of children with musculoskeletal conditions. He is past president of the Pediatric Orthopedic Society of North America and past chairman of the Orthopedic Section of the American Academy of Pediatrics. Douglas P. Hanel, MD, is chief of the Hand Clinic at Seattle Children’s Hospital; he is professor at the University of Washington School of Medicine and director of the orthopedic residency program. He trained in orthopedic surgery at St. Louis University and completed fellowships in hand surgery and microvascular surgery at the University of Louisville. He has completed the Teaching Scholars fellowship at Orthopedics the University of Washington. He has a predominant interest in surgery of the hand and the reconstruction of devastating limb injuries. Dr. Hanel has published more than 50 peer-reviewed articles and 13 book chapters; he is co-editor for the second edition of the textbook Harborview Orthopedic Trauma Protocols. He is principal investigator and co-investigator on two projects dealing with the outcomes of distal radius fractures. Dr. Hanel has editorial duties on The Journal of Bone and Joint, Microsurgery, Orthopedics Today, The American Journal of Orthopedic Surgery and Techniques in Hand and Upper Extremity Surgery. He has been honored for his teaching efforts at St. Louis University and Medical College of Wisconsin and has been recognized as a “Best Doctor” by Seattle magazine. Vincent S. Mosca, MD, is program director of clinical research in the Department of Orthopedics at Seattle Children’s Hospital and associate professor of orthopedics at the University of Washington School of Medicine. He is past director of the Department of Orthopedics at Seattle Children’s Hospital and chief of Pediatric Orthopedics at the University of Washington. He now spends time doing clinical research and writing, while maintaining his busy clinical practice. He is a member of 22 national and international professional organizations including the American Orthopedic Association, American Orthopedic Foot and Ankle Society and International Pediatric Orthopedic Think Tank. He is on the editorial board for the Journal of Pediatric Orthopedics and is chairman of the Education Council for the Pediatric Orthopedic Society of North America. Dr. Mosca has been repeatedly listed in “Best Doctors in America” and is listed in 10 other “Who’s Who” publications. He has been an invited guest speaker at more than 20 US medical centers and at more than 20 international orthopedic conferences. Dr. Mosca’s main area FACULTY Ernest U. Conrad III, MD, Director Michael J. Goldberg, MD Douglas P. Hanel, MD Vincent S. Mosca, MD Gregory Schmale, MD Kit Song, MD Theodore A. Wagner, MD Ernest U. Conrad III MD, Director of clinical and research interest, and the focus of most of his publications and presentations, is deformities of the child’s foot. More speciп¬Ѓcally, his work focuses on the identiп¬Ѓcation, classiп¬Ѓcation and treatment of sites of deformity. Gregory Schmale, MD, is program director of orthopedics medical education at Seattle Children’s Hospital and assistant professor in the Department of Orthopedics and Sports Medicine at the University of Washington School of Medicine. He earned his MD at the University of Washington and completed fellowship training in the Department of Orthopedics at the Children’s Hospital and University of Colorado Health Sciences Center. His clinical interests include general pediatric orthopedics and sports medicine. His research activities include anterior cruciate ligament reconstruction in the skeletally immature. Kit Song, MD, is assistant director of pediatric orthopedic surgery and acting head of spine surgery and head of the brachial plexus injury clinic at Seattle Children’s Hospital; he is associate professor of orthopedic surgery at the University of Washington School of Medicine. He completed his fellowship training in pediatric orthopedics at Texas Scottish Rite Hospital and was a member of the hospital staff there for three years. His clinical interests include pediatric spinal deformities with an emphasis on infantile deformities, musculoskeletal problems in children with neuromuscular disease, osteogenesis imperfecta, arthrogryposis and hip problems. His research includes bone and joint infections, functional activity of typically developing and disabled children, spinal cord monitoring for scoliosis surgery, vertical expandable titanium rib prosthesis (VEPTR) for the treatment of thoracic dysplasia and Legg-CalvГ©-Perthes disease in children. Theodore A. Wagner, MD, is attending physician at Seattle Children’s Hospital; he is clinical professor of spine surgery and joint clinical professor of neurosurgery at the University of Washington School of Medicine. He completed a residency at the University of Washington and a fellowship in spine surgery in Hong Kong. He has directed the Orthopedic Physician Associates Spine Fellowship and is a member of the international Scoliosis Research Society. Dr. Wagner’s special interest has been in spinal deformity and in establishing physician exchange programs with the developing world. He SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 55 Orthopedics has recently been honored to have research in tissue regeneration established in his name in the form of an endowed chair and hopes to direct that research in a signiп¬Ѓcant way. The focus of his clinical energies is in the area of spinal deformity, whether it is the result of fracture, tumor or adolescent deformities of kyphosis and scoliosis. Many of these conditions remain idiopathic and an effort should include a very exact data collection to help deп¬Ѓne the primary etiology. Secondary Deformities of Clubfoot — Classiп¬Ѓcation and Management, instructional course lecture, American Academy of Orthopedic Surgeons annual meeting, Washington, D.C., March 2005 TEACHING AND PRESENTATIONS Talipes Equinovarus and Maternal Smoking: A Population-Based Case-Control Study in Washington State, 2nd Joint Meeting of the International Federation of Foot and Ankle Societies, Naples, Italy, September 2005 Ernest U. Conrad III, MD A Comparison of Knee Implant Results in Pediatric vs. Adult Tumor Patients, abstract for poster presentation, Connective Tissue Oncology Society meeting, March 2005 Michael J. Goldberg, MD Evaluation and Management of Skeletal Dysplasia, instructional course lecture, American Academy of Orthopedics, 72nd annual meeting, Washington, D.C., February 2005 Raising Special Needs Kids: Health, Growth and Nutrition, Seattle, March 3, 2005 Limb Lengthening in Patients with Underlying Calcium Homeostasis Disorders, IPOTT annual meeting, Seville, Spain, September 2005 Are We Helping? How Do We Know?, presidential guest lecture, British Orthopaedic Association Annual Meeting, Birmingham, UK, September 2005 Detection and Management of Osteoporosis, 26th Annual Duncan Seminar, 2005 Vincent S. Mosca, MD Leg Length Discrepancy and Foot Problems in Children, LT Staheli Pediatric Orthopedic Seminar, Seattle Children’s, January 2005 Lower Extremity Pediatric Orthopedics: Knowledge Is Power, Washington State Chapter of NAPNAP annual meeting, Shoreline, Wash., March 2005 56 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Tarsal Osteotomies in the Child’s Foot, Treatment of Tarsal Coalition in Childhood, and Cavovarus Foot Deformity in Charcot-Marie-Tooth, 11th annual meeting of the German Orthopedic Foot and Ankle Society, Augsburg, Germany, April 2005 Classiп¬Ѓcation and Management of Cavovarus Foot Deformities; Diagnosis and Management of Tarsal Coalitions; Management of Secondary Deformities of Clubfoot; and The Adolescent Flatfoot, XI Scientiп¬Ѓc Meeting of the Hospital Ortopedico Infantil, Caracas, Venezuela, October 2005 Management of Painful Flatfeet in Adolescents; Management of Tarsal Coalitions; The Ponseti Method for Treatment of Clubfoot Deformities: The New (Old) Gold Standard; Cavovarus Foot Deformities in CMT Disease; and Management of Secondary Deformities of Clubfoot, XLI Chilean Congress of Orthopedics and Traumatology, Vina del Mar, Chile, November 2005 Pes Cavus: The Role of Tendon Transfers and Osteotomies; Adolescent Painful Flatfoot; Case Based-Discussion: What to Do When Ponseti and French Methods Yield Partial Correction; Case-Based Discussion: Foot and Ankle Pain in Children and Adults; and Breakout Session: Foot Osteotomies, 2nd International POSNA/ AAOS Pediatric Orthopedic Symposium, Orlando, Fla., December 2005 Gregory Schmale, MD Common Sports Injuries in Children and Adolescents and Common Pediatric Hip Problems, LT Staheli Pediatric Orthopedic Update, January 2005 Pediatric Foot, Gait, and Leg Disorders, American Academy of Family Physicians, Family Practice Board Review, April 2005 Orthopedics More Evidence of Inadequate Preparation in Musculoskeletal Medicine, Orthopedic Rehabilitation Association annual meeting, Seattle, September 2005 Lee MB, Schmale GA, Leopold SS. Total hip arthroplasty in the osteoporotic patient. Accepted to Advances in Osteoporotic Management. January 2006. Update on Sports Medicine, Pediatric Pearls for Ofп¬Ѓce Practice, September 2005 Lynch JR, Schmale GA, Schaad DC, Leopold SS. Important demographic variables impact musculoskeletal knowledge and conп¬Ѓdence of academic primary care physicians. Accepted to the J Bone Joint Surg, American. February 2006. The Limping Child, 33rd Annual Advances in Family Practice Conference, September 2005 Kit Song, MD Advances in Pediatric Orthopedic Surgery and Nursing Care of the Hospitalized Child, Seattle, April 2005 Non-Operative Management of Scoliosis; Pulmonary Effects of Scoliosis; Use and Abuse of Gait Analysis; Flexible and Rigid Flatfoot — Evaluation and Management; and Arthrogryposis — Lower Extremity Management, POSNA Croatia Outreach Course on Pediatric Orthopedic Surgery, Dubrovnik, Croatia, and Tallinn International Conference on Pediatric Orthopedics, Tallinn, Estonia, September 2005 Pulmonary Effects of Scoliosis, spine Grand Rounds, University of Washington, October 2005 PUBLICATIONS Chang A, Schuetze SM, Conrad EU, Swisshelm KL, Norwood TH, Rubin BP. So-called “inflammatory leiomyosarcoma”: a series of three cases providing additional insights into a rare entity. Int J Surg Pathol. 2005;13(2):185–195. Conrad EU, ed. Orthopedic Oncology Diagnosis and Treatment. New York: Thieme Publishing. 2006; in press. Conrad EU, Morgan HD, Leopold SS, Hawkins DS, Bolejack VJ, Morgan AC. A comparison of knee implant results in pediatric vs. adult tumor patients. Abstract for poster presentation at the Connective Tissue Oncology Society meeting. March 2005. Mosca VS, Hennrikus W. Ankle and foot: pediatrics. In: Orthopedic Knowledge Update 8. Vaccaro AR, ed. Rosemont: American Academy of Orthopedic Surgeons, 2005;757–765. Mosca VS. Parent’s guide to Ponseti clubfoot management. Global-HELP publication; 2005. Mosca VS, co-author and assistant editor. Clubfoot: Ponseti Management, 2nd ed. Staheli LT, ed. GlobalHELP Publication; 2005. Rubin BP, Conrad EU, et al. Deep-seated, well-differentiated lipomatous tumors of the chest wall and extremities: the role of cytogenetics in classiп¬Ѓcation and prognostication. Cancer. 2005; in press. Schmale GA. More evidence of inadequate preparation in musculoskeletal medicine. Clin Orthop Relat Res. Aug 2005;437:251–259. Schmale GA, Chansky HA, Raskind WH. Hereditary multiple exostoses. University of Washington, 2005. Schuetze SM, Rubin BP, Vernon C, Hawkins DS, Bruckner JD, Conrad EU, Eary JF. Use of positron emission tomography in localized, extremity soft tissue sarcoma treated with neoadjuvant chemotherapy. Cancer. 2005;103(2):339–348. Schuetze S, Rubin B, Vernon C, Hawkins D, Conrad EU, Eary JF, Brenner W. Metabolic imaging in the orthopedic population. Multimedia scientiп¬Ѓc exhibit #073, 72nd annual meeting of the American Academy of Orthopedic Surgeons, Washington, D.C., 2005. DuMontier TA, Falicov A, Mosca VS, Sangeorzan B. Calcaneal lengthening: investigation of deformity correction in a flatfoot model. Foot Ankle Int. 2005;26:166–170. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 57 Department of Pediatrics 58 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON The Department of Pediatrics is proud to again be a contributor to the University of Washington’s ranking as the number one primary care medical school in the nation and one of its top research medical schools. We are particularly proud of Dr. Frederick Rivara’s election to the Institute of Medicine in 2005. Dr. Rivara, division chief of General Pediatrics, has made many important contributions to the study of injury control methods. Growth in our transplant programs was a priority in 2005 with the recruitment of F. Bruder Stapleton, MD Pediatrician-in-Chief nationally renowned gastroenterologist Dr. Simon Horslen, director of our liver and intestinal transplant program. Our department has a growing interest in pediatric bioethics under the direction of Dr. Doug Diekema, interim director of the Treuman Katz Center for Pediatric Bioethics. The department’s pediatrics residency program continued to attract a record number of applicants from across the country. A new endocrine fellowship began in 2005. Our immunology program has become an international leader in the genetics of immunodeficiency disorders. We continue to be the coordinating center for new therapy trials for children with cystic fibrosis and a leader in child health outcomes research. Dr. Dimitri Christakis brought national attention to the department through work that highlights the association of early exposure to television with neurodevelopmental outcomes. The future looks very bright with our substantial group of exceptional young physician-scientists, 18 of whom hold mentored K-awards from the National Institutes of Health. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 59 Adolescent Medicine The Division of Adolescent Medicine (in the Department of Pediatrics) provides expert consultation, diagnosis and treatment for conditions commonly seen during adolescence, including mental health disorders, sexually transmitted diseases, such as human papilloma virus, eating disorders, obesity and chronic fatigue syndrome. Following a request, members of the division also provide medical consultation for patients throughout Seattle Children’s Hospital with conditions, such as chronic musculoskeletal pain, gynecologic issues and somatiform disorders. In the inpatient setting, providers coordinate closely with services such as nutrition and child psychiatry to assure a multidisciplinary approach to treatment. Patients are seen as outpatients following referral to the Adolescent Medicine Clinic, the Eating Disorders Clinic, the Headache and Biofeedback Clinic, the Reflex Neurovascular Dystrophy Clinic and the Adolescent Gynecology Clinic. When appropriate, patients seen in the outpatient setting are seen in consultation by members of our multidisciplinary team including physical and occupational therapy. Physicians and nurse practitioners in the section provide medical consultation for all patients with eating disorders who are admitted to the medical or psychiatric units. Members of adolescent medicine are committed to providing treatment for underserved adolescents in the community and also see patients at the Country Doctor Homeless Teen Clinic, which incorporates complementary and alternative medicine with acupuncture, massage and naturopathy. An additional clinic at the King County Juvenile Detention Center serves as a training site for pediatric and family medicine residents. Section providers also see patients at Harborview Medical Center as consultants, in the Children and Teens Clinic and in the Public Health Seattle & King County STD Clinic as attendings. Researchers in the Division of Adolescent Medicine are working to improve the understanding and treatment for conditions that are common for adolescents. TEACHING, RESEARCH AND CLINICAL EXPERTISE Mark S. Smith, MD, is chief of the Division of Adolescent Medicine at Seattle Children’s Hospital and professor of pediatrics at the University of Washington School of Medicine. He is director of the University of Washington’s adolescent medicine fellowship program and principal investigator of a federal grant that convenes community and academic pediatricians and child psychiatrists in collaboration about adolescent health issues. Additionally, Dr. Smith volunteers for one month a year at a hospital serving Mayan Indian children in Chiapas, Mexico. His clinical interests include psychophysiological disorders in adolescents and the effects of stress on organic disorders. His research interests include autonomic nervous system reactivity, the behavioral treatment of recurrent pediatric headache and chronic fatigue syndrome in adolescence. 60 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Cora C. Breuner, MD, MPH, is chief of the Adolescent Medicine Clinic at Seattle Children’s Hospital and associate professor of pediatrics at the University of Washington School of Medicine. She is also president of the Northwest Society of Adolescent Medicine. She received her MD from Jefferson Medical College in Philadelphia. She completed an internship and residency at the naval hospital in San Diego and completed a fellowship at the University of Washington. She is a board-certiп¬Ѓed adolescent medicine specialist and board-certiп¬Ѓed pediatrician. Dr. Breuner’s clinical interests include the treatment of eating disorders and obesity in adolescents. She is also interested in the management and treatment of adolescent headaches and stress-related disorders. Dr. Breuner’s research interests include the evaluation of yoga as an adjunctive intervention for patients with an eating disorder and the assessment of complementary medicine usage by pediatric patients with diabetes. She participates in the study Incorporating Complementary and Adolescent Medicine Alternative Medicine into a Medical School Curriculum. Her goal is to incorporate complementary and alternative medicine into the outpatient and inpatient programs at Seattle Children’s. Ann E. Giesel, MD, is chief of pediatric and adolescent gynecology at Seattle Children’s Hospital and clinical associate professor of pediatrics at the University of Washington School of Medicine. She serves as medical director of the King County Juvenile Detention Center Health Clinic and attends in Seattle Children’s Teen HIV Clinic and the Evening Clinics for Homeless Youth. She received her MD from the University of Louisville. She completed her pediatrics residency and a fellowship in adolescent medicine at the University of Washington and was a fellow in child sexual abuse at Harborview Medical Center. Dr. Giesel is a board-certiп¬Ѓed adolescent medicine specialist and board-certiп¬Ѓed pediatrician. Laura P. Richardson, MD, MPH, is director of the Adolescent Reflex Neurovascular Dystrophy Clinic at Seattle Children’s Hospital. She earned her MD and completed a combined residency in internal medicine and pediatrics at the University of Michigan, and she completed an adolescent medicine fellowship. She earned her MPH in epidemiology. Dr. Richardson specializes in the treatment of adolescents with chronic musculoskeletal pain conditions and has expertise in the treatment of conversion disorders, somatiform disorders, obesity, eating disorders, depression and anxiety. She is studying links between mental and physical health problems in adolescents and developing innovative interventions to improve the treatment of mental health conditions for adolescents in primary care settings. FACULTY Mark S. Smith, MD, Chief Cora C. Breuner, MD, MPH Ann E. Giesel, MD Laura P. Richardson, MD, MPH Taraneh Shafii, MD, MPH Mark S. Smith MD, Chief Taraneh Shafii MD, MPH, is attending physician at Seattle Children’s Hospital and acting assistant professor of pediatrics at the University of Washington School of Medicine. She serves as deputy medical director of the Public Health Seattle & King County STD Clinic. Among her clinical interests: adolescent reproductive health care including sexually transmitted diseases and unintended pregnancy; health manifestations of stress, anxiety and depression in adolescents; and overweight and eating disorders in adolescents. Dr. Shaп¬Ѓi’s research focuses on the development and assessment of primary and secondary interventions to reduce high-risk sexual behaviors in adolescents and the associated morbidity of sexually transmitted infections and unintended pregnancy. Her interests include early reproductive health education for youth and early adolescents and behavioral risk-reduction interventions for middle and older adolescents. AWARDS AND HONORS Cora C. Breuner, MD, MPH Listed in “Best Doctors 2005,” Seattle magazine RESEARCH FUNDING Continuing Laura P. Richardson, MD, MPH Improve Primary Care Management of Adolescent Depression, NIMH/NIH, $148,384 Mark S. Smith, MD Health Care for the Homeless Youth, Seattle – King County Department of Public Health, $55,000 Department of Youth Services Contract, Juvenile Detention, Juvenile Division (DAJD), $203,335 TEACHING AND PRESENTATIONS Cora C. Breuner, MD, MPH Herb Drug Interaction, noon conference, Seattle Children’s, January 28, 2005 Substance Abuse, noon conference, Seattle Children’s, February 18, 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 61 Adolescent Medicine Herbal Medicine in Adolescents: Who, What, When, Where, and How?, Society for Adolescent Medicine annual meeting, Los Angeles, March 2005 Sex, Drugs, and Rock and Roll: All You Need to Know About Taking Care of Teenagers!, pediatric clerkship lecture, Seattle Children’s, April 21, 2005 Bulimia, interdisciplinary conference, Seattle Children’s, May 2005 Eating Disorders in Adolescents, noon conference, Seattle Children’s, July 27, 2005 Obesity, Drug Use in Teens & Adolescent Violence, Portneuf Medical Center and Pocatello Children’s Clinic, Pocatello, Idaho, August 23, 2005 Obesity, St. Luke’s Regional Medical Center, Boise, Idaho, August 24, 2005 Ann E. Giesel, MD Introduction to Adolescent Medicine, pediatric clerkship lecture, Seattle Children’s, January 20, 2005 Dysfunctional Uterine Bleeding, lecture to emergency medicine fellows, Seattle Children’s, March 7, 2005 Menstrual Disorders, Multicare Health System, Tacoma, Wash., September 17, 2005 Menstrual Disorders, noon conference, Seattle Children’s, September 22, 2005 Contraceptive Update, Peninsula Children’s Clinic, Great Falls, Mont., 2005 Laura P. Richardson, MD, MPH Behavioral Aspects and Management of Pain and Somatic Complaints in Adolescents, Grand Rounds presentation, Seattle Children’s, February 3, 2005 Anxiety and Depression, adolescent medicine medical meeting, Seattle Children’s, August 24, 2005 Taraneh Shafii, MD, MPH STD Screening, adolescent medicine medical meeting, Seattle Children’s, August 31, 2005 Approach to Adolescents, Harborview Medical Center, Seattle, 2005 Adolescent Gynecological Issues, noon conference, Seattle Children’s, March 18, 2005 STDs in Adolescents: Special Concerns, STD clinical update, Seattle STD/HIV Prevention Training Center, Seaside, Ore., 2005 Pelvic Pain, monthly interdisciplinary conference, Seattle Children’s, April 2005 Adolescent Sexuality: ICM II Spring Quarter Human Sexuality, University of Washington, 2005 Sexuality and Persons with Disabilities, Center on Human Development and Disability, Seattle, Wash., April 4, 2005 Mark S. Smith, MD Adolescent Medicine Issues, pediatric clerkship lecture, Seattle Children’s, March 24, 2005 Pediatric Gynecology and Sexual Abuse Cases, Children’s Urology Conference, Seattle Children’s, June 7, 2005 Hypnosis for Pediatric Medical Disorders, interdisciplinary conference, Seattle Children’s, March 2005 Introduction to Adolescent Medicine, pediatric clerkship lecture, Seattle Children’s, July 14, 2005 Physical Exam, lecture to child psychiatry residents, Seattle Children’s, July 15, 2005 Contraception, adolescent medicine medical meeting, Seattle Children’s, July 20, 2005 62 Contraception Update, collaborative ofп¬Ѓce rounds, Seattle Children’s, September 13, 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Hypnosis with Adolescents, Society for Adolescent Medicine annual meeting, Los Angeles, March 2005 Chronic Fatigue, monthly interdisciplinary conference, Seattle Children’s, June 2005 Smoking, collaborative ofп¬Ѓce rounds, Seattle Children’s, July 12, 2005 Adolescent Medicine Psychosomatic Disorders, adolescent medicine medical meeting, Seattle Children’s, July 13, 2005 Pediatrics Among the Maya, Doctors of the World, New York, September 27, 2005 Adolescent Medicine Issues, pediatric clerkship lecture, Seattle Children’s, December 15, 2005 Chronic Fatigue, pediatric Grand Rounds, Sacred Heart Medical Center, Spokane, Wash., April 13, 2005 Psychosomatic Disorders, Pediatric Society dinner, Spokane, Wash., April 13, 2005 PUBLICATIONS Shaп¬Ѓi T, Kerani T, Holmes K, Handsп¬Ѓeld H, Golden M. Role of TPPA in the diagnosis of early syphilis among men who have sex with men in King County, Washington. The 16th Biennial Meeting of the International Society for Sexually Transmitted Diseases Research (ISSTDR), Amsterdam, Netherlands, July 2005. Shaп¬Ѓi T, Stovel K, Holmes K. Early condom use by adolescents does not predict increased number of sex partners; it does predict lower rates of STIs: a longitudinal study with biomarkers. The 2005 Annual Meeting of the Society for Adolescent Medicine, Los Angeles, March 2005. Smith MS. Chronic fatigue syndrome. In: Pediatric Medicine, 3rd edition, Avery ME, First LR, eds. Baltimore: Williams and Wilkins, 2005. Breuner CC. Natural contraception. Adol Med Clinic. 2005;16:603–616. Garrison MM, Katon W, Richardson LP. The impact of psychiatric comorbidities on readmissions for diabetes in youth. Diabetes Care. 2005;28(9):2150–2154. Hodes M, Calderon R, Breuner CC, Varley C. Treatment of eating disorders in children and adolescents. In: The Cambridge Handbook of Effective Treatments in Psychiatry. 2005. Kerani RP, Handsп¬Ѓeld HH, Stenger MS, Shaп¬Ѓi T, Zick E, Brewer D, Golden MR. Rising rates of syphilis in the era of syphilis elimination. The 16th Biennial Meeting of the International Society for Sexually Transmitted Diseases Research (ISSTDR), Amsterdam, Netherlands, July 2005. Lewis CW, Lynch H, Richardson LP. Fluoride varnish use in primary care: what do providers think? Pediatrics. 2005;115:e69–e76. Richardson LP, Katzenellenbogen R. Childhood and adolescent depression: the role of primary care providers in diagnosis and treatment. Curr Probl Pediatr Adolesc Health Care. 2005;35(1):6–24. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 63 Cardiology The Division of Cardiology (in the Department of Pediatrics) is part of Seattle Children’s Heart Center, a specialized team of pediatric cardiologists, cardiac surgeons, pediatric cardiac intensive care specialists, cardiac anesthesiologists, nurses, echocardiographic technicians and caring staff. We are a comprehensive cardiac care provider for the fetus to the adult, and our commitment to the best possible outcome for each patient includes ongoing research into new treatments and technologies. We have a reputation for excellence in services ranging from advanced therapeutic catheterization procedures for common cardiac defects and heart rhythm disorders to heart transplantation for infants with more complex cardiac problems. The Division of Cardiology is committed to achieve greater national recognition as a leader in innovation, collaboration and excellence. Our faculty’s intellectual curiosity and spirit of inquiry define our culture, and our research and clinical care partnerships provide models for our peers. TEACHING, RESEARCH AND CLINICAL EXPERTISE Robert J. Boucek Jr., MD, is chief of the Division of Cardiology and co-director of the Heart Center at Seattle Children’s Hospital. He is a professor and chief of the Division of Cardiology in the Department of Pediatrics at the University of Washington School of Medicine. He holds the Thomas Bradley Armstrong Endowed Chair in Pediatric Cardiology. He received his MD from Tulane University Medical School in New Orleans. He completed a pediatrics internship and residency at Duke University Medical Center in Durham, N.C. and fellowships in biochemistry and pediatric cardiology at Vanderbilt University Medical Center in Nashville, Tenn. Dr. Boucek was the п¬Ѓrst medical director for the pediatric heart transplant programs at Vanderbilt and at the University of South Florida/All Children’s Hospital. He remains active in clinical research pertaining to cardiac transplantation. His basic research includes a collaboration on myocardial regeneration strategies as applied to right ventricular failure. He is principal investigator for a study of the role of pro-apoptotic phenotype in premature right ventricular failure. Dr. Boucek’s vision is to develop a nationally recognized Heart Center at Seattle Children’s. Terrence U. Chun, MD, is attending pediatric cardiologist and pediatric electrophysiologist at Seattle Children’s Hospital and assistant professor at the University of Washington School of Medicine. Dr. Chun received his MD from Hahnemann University School of Medicine in Philadelphia and completed his pediatrics residency 64 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON at Cedars-Sinai Medical Center in Los Angeles. He also did fellowships in pediatric cardiology at Cincinnati Children’s Hospital and a joint pediatric electrophysiology fellowship at University of California, San Francisco and Stanford University School of Medicine. Dr. Chun has expertise and training in pediatric cardiology, pediatric electrophysiology and implantation of pacemakers and deп¬Ѓbrillators. Speciп¬Ѓc areas of clinical interest include catheter ablation of cardiac arrhythmias, postoperative arrhythmias, implantable device therapy for treatment of arrhythmias and prevention of sudden cardiac death. Michelle Z. Gurvitz, MD, is attending physician at Seattle Children’s Hospital and assistant professor of pediatrics at the University of Washington School of Medicine. She cares for children on an outpatient basis in Seattle Children’s Heart Center and at Group Health Eastside and attends and consults on the inpatient service at Children’s. Dr. Gurvitz also participates in a unique program with Children’s and the university that supports the transition of older children with congenital heart disease from pediatric to adult cardiology care. Dr. Gurvitz received her MD from the University of California, Los Angeles School of Medicine. She completed her internal medicine/pediatrics residency at the Cedars-Sinai Medical Center and her pediatric cardiology fellowship at the Mattel Children’s Hospital at UCLA. Dr. Gurvitz earned an MPH at the UCLA School of Public Health. She is board certiп¬Ѓed in pediatrics, pediatric cardiology and internal medicine. Dr. Gurvitz has expertise and training in adolescent and adult congenital heart disease. Speciп¬Ѓc areas of clinical Cardiology research interest include the transition of adolescents with congenital heart disease to adult care and the epidemiology of adults with congenital heart disease. Bruce Hardy, MD, is a pediatric cardiologist who maintains a close afп¬Ѓliation with Seattle Children’s Hospital. He practices in Missoula, Mont., and in outreach clinics throughout western Montana. Dr. Hardy travels monthly to Seattle Children’s and participates twice a week in cardiology conferences as part of telemedicine. He earned his MD at the University of Washington School of Medicine. He completed an internship at the University of Vermont, a pediatrics residency at the University of Utah and a pediatric cardiology fellowship at Oregon Health Sciences University. He is board certiп¬Ѓed in pediatrics and pediatric cardiology. He is a fellow of the American Academy of Pediatrics and the American College of Cardiology. Dr. Hardy also teaches in the Department of English at the University of Montana, specializing in James Joyce. Troy A. Johnston, MD, is assistant director of the cardiac catheterization laboratories at Seattle Children’s Hospital and assistant professor in the Department of Pediatrics at the University of Washington School of Medicine. He is certiп¬Ѓed by the American Board of Pediatrics and the sub-board in pediatric cardiology. Dr. Johnston is director of the pediatric cardiology clerkship for medical students and residents. He has developed a curriculum that exposes the trainee to the basics of the sub-specialty, and he works with residents and students on a one-on-one basis. He also supervises residents and students on the inpatient cardiology service. Dr. Johnston has participated in many multi-institutional clinical trials of devices used in transcatheter treatment of congenital heart disease and has successfully recruited patients to participate FACULTY Robert J. Boucek Jr. MD, Chief Robert J. Boucek Jr., MD, Chief Terrence U. Chun, MD Michelle Z. Gurvitz, MD Bruce Hardy, MD Troy A. Johnston, MD Thomas K. Jones, MD Isamu Kawabori, MD Mark B. Lewin, MD Michael A. Portman, MD Jack C. Salerno, MD in these trials. Additionally, he has played an integral role in writing proposals, abstracts and manuscripts for transcatheter treatment of congenital heart disease and has led a research project examining the use of technology to improve the auscultation skills of pediatric trainees. He has been an abstract reviewer for the annual scientiп¬Ѓc session of the Society of Cardiovascular Angiography and Interventions. Thomas K. Jones, MD, is director of the cardiac catheterization laboratories at Seattle Children’s Hospital and professor of pediatrics at the University of Washington School of Medicine. He is a graduate of the Jefferson Medical College in Philadelphia. He completed his pediatrics residency at the University of Washington and his pediatric cardiology fellowship at the University of Colorado and the Denver Children’s Hospital. He is a fellow of the American Academy of Pediatrics, the American College of Cardiology and the Society for Cardiovascular Angiography and Interventions. Dr. Jones’ work has focused on congenital interventional cardiac catheterization, and he has been co-investigator on virtually every multicenter clinical trial in the US evaluating devices and procedures developed for this patient population. He has served on numerous national committees and task forces promoting guidelines and practice standards for patients with congenital heart disease. Dr. Jones collaborates with emerging technology companies developing and testing new products designed to treat these conditions. Isamu Kawabori, MD, is attending cardiologist at Seattle Children’s Hospital and associate professor in the Department of Pediatrics in the University of Washington School of Medicine. He attends in Seattle Children’s Heart Center, Children’s Bellevue Cardiology Clinic, Swedish Medical Center and Central Washington Hospital in Amy H. Schultz, MD J. Geoff Stevenson, MD Wenatchee. His teachKaren Stout, MD ing responsibilities at Delphine Yung, MD the university include pediatric cardiology and rehabilitation courses. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 65 Cardiology Mark B. Lewin, MD, is co-director of the cardiac ultrasound program at Seattle Children’s Hospital and associate professor in the Department of Pediatrics at the University of Washington School of Medicine. Dr. Lewin’s clinical responsibilities at Seattle Children’s include cardiology, transesophageal echocardiograms, echocardiography and cardiovascular genetics clinics. He is also involved in the regional fetal echocardiography service and the statewide echocardiography telemedicine service. Dr Lewin is pediatric preceptor of the medical student course, and he mentors residents in pediatrics who have a special interest in cardiology or genetics. Michael A. Portman, MD, is director of research in the Division of Cardiology at Seattle Children’s Hospital and professor in the Department of Pediatrics at the University of Washington School of Medicine. He is attending physician at Seattle Children’s Heart Center and the Cardiology Clinic at Providence Everett Medical Center. Dr. Portman’s research activities include pharmacological clinical trials, basic science research projects focused on cardiac metabolism in animal models and mentoring future clinical researchers. He is an editorial board member of the American Journal of Physiology — Heart and Circulatory Physiology and co-investigator for a grant on cardiovascular research training. Jack C. Salerno, MD, is director of the electrophysiology and pacing service at Seattle Children’s Hospital and an assistant professor of pediatrics in the Cardiology Division at the University of Washington School of Medicine. He cares for patients in Seattle Children’s Heart Center and the electrophysiology laboratory and also attends and consults on the inpatient service at Children’s. Dr. Salerno received his MD from the University of California, San Diego. He completed his pediatric residency at UCSD and did fellowships in pediatric cardiology and electrophysiology at Baylor College of Medicine in Houston. Dr. Salerno has expertise and training in pediatric cardiology, electrophysiology and pacemaker implantation. Speciп¬Ѓc areas of clinical interest include long QT syndrome and congenital atrioventricular block. 66 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Amy H. Schultz, MD, is attending physician at Seattle Children’s Hospital and assistant professor of pediatrics at the University of Washington School of Medicine. Dr. Schultz sees outpatients in Seattle Children’s Heart Center and at Children’s Olympia. She also attends and consults on the inpatient service at Children’s. Dr. Schultz received her MD from the University of Pennsylvania School of Medicine in Philadelphia. She completed her pediatrics internship and residency at Johns Hopkins Hospital in Baltimore and her pediatric cardiology fellowship at The Children’s Hospital of Philadelphia; she obtained additional training in clinical epidemiology at the University of Pennsylvania School of Medicine. She is board certiп¬Ѓed in pediatrics and pediatric cardiology. Dr. Schultz has expertise and training in echocardiography. Her speciп¬Ѓc areas of clinical research interest include identiп¬Ѓcation of newborns with critical congenital heart disease. J. Geoff Stevenson, MD, is director of cardiac ultrasound at Seattle Children’s Hospital and professor of pediatrics at the University of Washington School of Medicine. His clinical, research and teaching interests are in pediatric cardiology, pediatric cardiac ultrasound and instrumentation, intraoperative echocardiography and international cardiac ultrasound education. He is a working advocate for the profession of sonography in conjunction with the American Registry for Diagnostic Medical Sonography. He is a fellow of the American College of Cardiology and the American Society of Echocardiography and has served on numerous committees, consensus groups and standards writing committees for both organizations. He is author of more than 100 peer-reviewed papers and book chapters, has given more than 335 academic and teaching presentations in 26 countries and has won awards for his contribution to pediatric echocardiography. Karen Stout, MD, teaches in the outpatient clinics at Seattle Children’s Hospital and is assistant professor at the University of Washington School of Medicine. She is director of the Adult Congenital Heart Disease program at the university and she teaches inpatient and outpatient echocardiography. Her clinical interests include adolescent and adult congenital heart disease. Her research focuses on adolescent and adult congenital heart disease, as well as pregnancy and heart disease. Cardiology Delphine Yung, MD, is attending cardiologist at Seattle Children’s Hospital and assistant professor of pediatrics at the University of Washington School of Medicine. She cares for children in the outpatient clinic in Seattle Children’s Heart Center and also attends and consults on the inpatient service. Dr. Yung received her MD from Stanford University. She completed an internship and junior residency in pediatrics at Children’s Hospital Boston and a senior residency in pediatrics at Lucile Packard Children’s Hospital in Stanford. She completed her pediatric cardiology fellowship at Children’s Hospital of New York, Columbia University. Dr. Yung has expertise and training in all aspects of pediatric cardiology, particularly pulmonary hypertension and exercise testing. Her clinical interests include cardiomyopathy, pulmonary hypertension, transplant and the exercise lab at Children’s Heart Center. Her current research focuses on exercise capacity in patients with repaired tetralogy of Fallot. A Multicenter, Placebo-Controlled, Eight-Month Study of the Effect of Twice-Daily Carvedilol in Children with Congestive Heart Failure due to Systemic Ventricular Systolic Dysfunction, University of Utah, GlaxoSmithKline, $57,615 AWARDS AND HONORS Cardiolite 301, Bristol Myers Squibb Medical Imaging, $252,849 Robert J Boucek Jr., MD Thomas Bradley Armstrong Chair in Pediatric Cardiology, awarded 2005 Mark B. Lewin, MD Presentation award, Fifth International Conference on Successes and Failures in Telehealth, Brisbane, Australia, August 2005 RESEARCH FUNDING New Michael A. Portman, MD A Randomized Double-Blind, Placebo-Controlled, Dose-Ranging, Parallel Group Study of Oral Sildenaп¬Ѓl in the Treatment of Children, 1-16 Yrs, with Pulmonary Hypertension, Pп¬Ѓzer, Inc., $155,987 A Multicenter, Open-Label Extension Study to Evaluate the Safety of Twice-Daily Oral Carvedilol in Pediatric Patients with Chronic Heart Failure, University of Utah, GlaxoSmithKline, $62,645 A Multicenter, Long-Term Extension Study to Assess the Safety of Oral Sildenaп¬Ѓl in the Treatment of Subjects Who Have Completed Study A1481131, Pп¬Ѓzer, Inc., U.S. Pharmaceuticals Group, $104,813 Triostat in Children During CPB Supplement, Food & Drug Administration, $350,000 Delphine Yung, MD Case History: International, Multicenter Trial to Evaluate the Efп¬Ѓcacy and Safety of Cardiolite Myocardial Perfusion Imaging in Pediatric Subjects with Kawasaki Disease, Protocol Cardiolite 302, Bristol Myers Squibb Medical Imaging, $165,180 DuP 843-201: A Phase I-II, Open-Label, Multicenter Trial to Determine the Dosimetry and Safety of Technetium Tc99m Sestamibi in Pediatric Subjects, Bristol Myers Squibb Medical Imaging, $55,269 Continuing Michael A. Portman, MD Triostat in Children During CPB, Food & Drug Administration, $388,757 Thyroid Regulation in the Developing Heart, National Heart, Lung, and Blood Institute/NIH/ DHHS, $139,184 TEACHING AND PRESENTATIONS Robert J. Boucek Jr., MD Assessment of Right Ventricular Function by Echocardiography, International Symposia on Congenital Heart Disease, February 2005 Terrence U. Chun, MD Pacemakers and Deп¬Ѓbrillators, surgical floor nursing education, Seattle Children’s, February 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 67 Cardiology Sudden Cardiac Death in Children, cardiology fellow EP lecture, University of Washington Medical Center, March 2005 Basic Electrocardiography, residency core curriculum, Seattle Children’s, March 2005 Pacing 101, PICU orientation core lecture, Seattle Children’s, March 2005 Arrhythmias for the General Pediatrician, residency noon lecture, Seattle Children’s, July 2005 Complex Cases in Pediatric EP, NW Young EP Symposium, July 2005 Complex Electrocardiograms, residency noon lecture, Seattle Children’s, August 2005 Cardiac Emergencies, residency noon lecture, Seattle Children’s, December 2005 Michelle Z. Gurvitz, MD Intraoperative Pulmonary Artery Stenting: An Alternative Technique for the Management of Congenital Pulmonary Artery Stenosis in Adjunct with Surgical Repairs, annual meeting of the Society of Thoracic Surgeons, Tampa, Fla., January 2005 Inpatient Service Utilization of Congenital Heart Disease Patients Surrounding the Transition to Adulthood, annual meeting of the Pediatric Academic Societies, Washington, D.C., May 2005 Implementing Quality Improvement in a Pediatric Cardiology Clinic and Insurance Patterns of Hospitalized Young Adults with Congenital Heart Disease: What Predicts Private Insurance?, American Academy of Pediatrics annual meeting, Washington, D.C., October 2005 Ventricular Septal Defect: From Simple to Eisenmenger, Ahmanson-UCLA Adult Congenital Heart Center Conference on Complex Management of Adults with Congenital Heart Disease, Los Angeles, 2005 Troy A. Johnston, MD Pediatric Cardiology: An Introduction, MEDEX Northwest Physician Assistant Program, Seattle, April 27, 2005 68 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Thomas K. Jones, MD ASD & PFO Transcatheter Management, Cath Lab Conference, Swedish Heart Center, Seattle, January 4, 2005 Holes in the Heart, Oregon Heart and Vascular Institute, cardiology Grand Rounds, Eugene, Ore., March 2005 Patent Ductus Arteriosus and Perivalvular Leaks, ACCIS 2005, Interventional Approaches for Structural Heart Disease, 54th Annual Scientiп¬Ѓc Session, American College of Cardiology, Orlando, Fla., March 6, 2005 Heart Disease in Children and Adolescents, Family Practice Board review, American Academy of Family Physicians, Seattle, April 22, 2005 PFO and Stroke: Cause or Innocent Bystander?, 28th Scientiп¬Ѓc Sessions, Society for Cardiovascular Angiography and Interventions, Ponte Vedra Beach, Fla., May 6, 2005 Interventional Catheterization, “Day of Honor” celebration, Seattle Children’s, June 30, 2005 Structural Heart Disease, Scope of the Problem, and Emerging Technologies Symposium session moderator, Summer in Seattle (SIS) 2005, Seattle, July 20, 2005 Cath Lab Rounds, PFO, and ASD, Summer in Seattle (SIS) 2005, Seattle, July 21, 2005 PFO: Technique and Strategy and live case moderator, Summer in Seattle (SIS) 2005, Seattle, July 22, 2005 Pivotal Trial Results, Gore HELEX Septal Occluder investigator’s meeting, Seattle, July 23, 2005 HELEX Septal Occluder — A Critical Look at Factors for Success, Pediatric Interventional Cardiac Symposium (PICS/ENTICHS-2005), Buenos Aires, Argentina, September 15, 2005 Stents, Program moderator, Pediatric Interventional Cardiac Symposium (PICS/ENTICHS-2005), Buenos Aires, Argentina, September 16, 2005 Cardiology Mark B. Lewin, MD Accuracy and Utility of Real-Time Pediatric Echocardiographic Transmission Via Telemedicine, platform presentation, Fifth International Conference on Successes and Failures in Telehealth, Brisbane, Australia, August 2005. Karen Stout, MD Cardiology Pearls, American College of Physicians National Board Review Course, 2005 Sudden Death: Preparticipation Cardiac Screening of the Young Athlete, invited lecturer, 19th annual A Day in the Ofп¬Ѓce: Problems in Pediatric Practice, sponsor: Group Health Cooperative, Seattle, April 2005. Cardiology Gems, Washington Chapter, American College of Physicians, Seattle, 2005 Pediatric Cardiology: An Overview of the Field, invited lecturer, physical therapy graduate program, University of Puget Sound, Tacoma, Wash., May 2005. Perinatology visiting professor program, fetal cardiac evaluation, Grand Rounds, Yakima Valley Memorial Hospital, Yakima, Wash., August 2005. How-To Session: Genetic Testing in Pediatric Heart Disease, 2005 Scientiп¬Ѓc Sessions, American Heart Association, Dallas, November 2005. Michael A. Portman, MD Obtaining Funding from the Food and Drug Administration, American Pediatric Society, Washington, D.C., 2005 Jack C. Salerno, MD Syncope, residency noon lecture, Seattle Children’s, May and August 2005 Morning Report: ECG Unknowns, residency noon lecture, Seattle Children’s, October and December 2005 J. Geoff Stevenson, MD Congenital Heart Disease: Evaluation of Unoperated Common Congenital Defects and Congenital Heart Disease: Assessment After “Corrective” or Palliative Surgery, Paciп¬Ѓc Northwest Review of Perioperative Echocardiography, Seattle, 2005 Complications During Pediatric Transesophageal Echocardiography: Low and Avoidable and Does the Age at Presentation Affect the Natural History of Mild Isolated Valvular Pulmonary Stenosis?, World Congress of Pediatric Cardiology and Cardiac Surgery, Buenos Aires, Argentina, 2005 Update in Heart Failure, emergency medicine Grand Rounds, Seattle, Wash., 2005 Pregnancy and Congenital Heart Disease, American Association of Pediatrics national meeting, Washington, D.C., October 2005 Diastolic Dysfunction, American College of Physicians regional meeting, Seattle, November 2005 Adults with Congenital Heart Disease, Washington Chapter, American College of Cardiology annual session, December 2005 Thomas K. Jones, MD Visiting proctorship, proctored Dr. Samuel Lau in performance of Amplatzer septal occluder closure of atrial septal defects, Sacred Heart Medical Center, Eugene, Ore., March 2, 2005 PFO: Technique and strategy, Summer in Seattle Interventional Cardiovascular Symposium, Webcast, Seattle Visiting proctorship, proctored Dr. David Jessup in performance of Amplatzer PFO occluder closure of patent foramen ovale, St. Joseph Medical Center, Bellingham, Wash., March 24, 2005 Visiting proctorship, proctored Dr. Todd Caulп¬Ѓeld in performance of Amplatzer septal occluder closure of atrial septal defects, St. Vincent Medical Center, Portland, Ore., June 3 and September 6, 2005 Karen Stout, MD Care of Adults with Congenital Heart Disease, nursing annual educational session, University of Washington Medical Center, 2005 Visiting professor, interventional cardiology, Yakima/ Toppenish, Wash., October 26–27, 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 69 Cardiology PUBLICATIONS Berman Rosenzweig E, Dunbar Ivy D, Widlitz A, Doran A, Claussen LR, Yung D, Abman SH, Morganti A, Nguyen N, Barst RJ. Effects of long-term bosentan in children with pulmonary arterial hypertension. J Am Coll Cardiol. 2005;46:697–704. Boucek RJ Jr., Martinez R. Echocardiographic determination of right ventricular function. Cardiology in the Young. 2005;15:48–51. Chang RK, Gurvitz M, Rodriguez S, Hong E, Klitzner TS. Current practice of exercise stress testing among pediatric cardiology and pulmonology centers in the United States. Pediatr Cardiol. Oct 18, 2005; e-publication. Chrisant MRK, Naftel DC, Drummond-Webb J, Chinnock R, Canter CE, Boucek, MM, Boucek RJ Jr., Hallowell SC, Kirklin JK, Morrow WR, the Pediatric Heart Transplant Study Group. Fate of infants with hypoplastic left heart syndrome listed for cardiac transplantation: a multicenter study. J Heart Lung Transplant. 2005;24:576–582. Danzi S, Klein I, Portman MA. Triiodothyronine mediates gene transcription in human heart. Am J Card. 2005;95(6):787–789. Gurvitz M, Chang R-KR, Ramos FJ, Allada V, Child JS, Klitzner TS. Variations in congenital heart disease training in adult and pediatric cardiology fellowship programs. J Am Coll Cardiol. Sept 2005;46:893–898. McBride KL, Pignatelli R, Lewin M, Ho T, Fernbach S, Menesses A, Lam W, Leal SM, Kaplan N, Schliekelman P, Towbin JA, Belmont JW. Inheritance analysis of congenital left ventricular outflow tract obstruction malformations: Segregation, multiplex relative risk, and heritability. Am J Med Genet. Feb 2, 2005; e-publication. Ploplys EA, Muzaffar AR, Stevenson JG, Cohen GC. Direct microvascular repair of an infant’s transected coronary artery. J Reconstructive Microsurgery. 2005;21(8):547–549. 70 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Portman MA, Qian K, Krueger J, Ning XH. T3 directly modiп¬Ѓes phosphorylation potential in sheep heart in vivo. Am J Physiol Heart Circ Physiol. 2005;288:2484–2490. Portman MA, Zhang J. Myocardial Energy transport and heart failure. Current Cardiology Reviews. 2005; 1(1):17–27. Quintessenza JA, Jacobs JP, Morell VO, Giroud JM, Boucek RJ Jr. The initial experience with a bicuspid polytetrafluoroethylene pulmonary valve in 41 children and adults: a new option for right ventricular outflow tract reconstruction. Annals of Thoracic Surgery. 2005;79:924–931. Schultz AH, Jarvik GP, Wernovsky G, Bernbaum J, Clancy RR, D’Agostino JA, Gerdes M, McDonaldMcGinn D, Nicolson SC, Spray TL, Zackai E, Gaynor JW. Effect of congenital heart disease on neurodevelopmental outcome within multiple gestation births. J Thorac Cardiovasc Surg. 2005;130(6):1511–1516. Steele A, Gok F, Marikar Y, Steele P, Chamizo W, Scott M, Boucek RJ Jr. Resident stem-like cells trafп¬Ѓc from heart ex vivo, expanded in vitro, can be transplanted in vivo. J Heart Lung Transplant. 2005;24:1930–1939. Craniofacial Medicine The Division of Craniofacial Medicine (in the Department of Pediatrics) aims to provide and coordinate the highest-quality interdisciplinary care of patients with congenital and acquired craniofacial conditions. Our faculty’s expertise spans the fields of epidemiology, genetics, developmental biology and clinical research. We provide outpatient and inpatient care at Seattle Children’s and comprehensive consultations at both Children’s and the University of Washington. Pediatric craniofacial medicine faculty coordinate care through Seattle Children’s Craniofacial Center and several specialty clinics. These clinics include the Plagiocephaly Clinic, which focuses on the diagnosis and management of postnatal deformational plagiocephaly; the Prenatal Clinic, which provides prenatal assessment, education and counseling for mothers and families after the prenatal diagnosis of a craniofacial condition; and the Craniofacial Genetics Clinic, which provides focused diagnostic evaluations, education and counseling for families affected by craniofacial conditions. These clinical programs provide long-term management of craniofacial conditions, including family education. We also pursue state-of-the-art clinical research to develop improved diagnostic, preventive and health care delivery strategies. The chief of the Division of Craniofacial Medicine also directs the Center for Craniofacial Research, which supports interdisciplinary research for the division. Our long-term goal is to develop an interdisciplinary research program that parallels our clinical center and to become an international leader in craniofacial-related science. TEACHING, RESEARCH AND CLINICAL EXPERTISE Michael L. Cunningham, MD, PhD, is chief of the Division of Craniofacial Medicine at Seattle Children’s Hospital and associate professor of pediatrics at the University of Washington School of Medicine. He is medical director of Seattle Children’s Craniofacial Center and the Jean Renny Endowed Chair in Craniofacial Medicine. He is also adjunct associate professor at the university School of Medicine and School of Dentistry. Dr. Cunningham balances responsibilities in administration, patient care and research. He does bedside teaching FACULTY Michael L. Cunningham MD, PhD, Chief Michael L. Cunningham, MD, PhD, Chief Timothy C. Cox, PhD Carrie L. Heike, MD, MS Anne V. Hing, MD Charlotte W. Lewis, MD, MPH Wendy Mouradian, MD, MS Jacqueline R. Starr, PhD, MS, MPH of medical students, dental students and pediatric residents. His clinical interests focus on the diagnosis and long-term interdisciplinary care of children with craniofacial malformations with a particular interest in the craniosynostoses. He is co-investigator on several clinical research projects, ranging from the epidemiology of positional plagiocephaly to the risk factors for obstructive sleep apnea. Dr. Cunningham’s basic molecular and developmental biology lab has been open since 1993 and is using mouse and tissue culture models to investigate the molecular causes of craniosynostosis and developmental pathogenesis of midface hypoplasia associated with syndromic craniosynostosis. Timothy C. Cox, PhD, is research associate professor of pediatrics at the University of Washington and an adjunct faculty member in the Department of Oral Biology. His primary research interests focus on the genetic and epigenetic factors that regulate development of the craniofacial region and how perturbations in these factors contribute in particular to the presentation of cleft lip and palate. He has also had a long interest and involvement in both X-linked and mitochondrial diseases. His research team employs existing and newly developed in-house genetic technologies to create and investigate mouse and SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 71 Craniofacial Medicine chick embryo models of cleft lip and palate. Dr Cox’s interests also extend to other craniofacial malformations (most notably the craniosynostoses) and the development of strategies to better diagnose, manage and counsel patients. He held several leading positions in craniofacial medicine in Australia, including director of genetic programs at the Australian Craniofacial Unit and co-director of Monash University’s MouseWorks, a highly regarded mouse genetic modiп¬Ѓcation facility. Carrie L. Heike, MD, MS, is acting instructor in the Department of Pediatrics at the University of Washington School of Medicine. She completed a clinical fellowship in the Craniofacial Center at Seattle Children’s Hospital. Dr. Heike’s research focuses on the genetic epidemiology of craniofacial conditions. She has a special interest in working with families and children with 22q11.2 deletion syndrome. She is investigating the genetic variation in children with this syndrome and aims to understand whether this variation contributes to the development of craniofacial anomalies in 22q11.2 deletion syndrome. She is also using three-dimensional imaging combined with anthropometry to quantify the craniofacial variation in syndromes that affect craniofacial structures. Anne V. Hing, MD, is attending physician at Seattle Children’s Hospital and assistant professor in the Department of Pediatrics at the University of Washington School of Medicine and an adjunct faculty member in the Division of Medical Genetics. Her clinical interests include the diagnosis and management of infants, children and adolescents with craniofacial and genetic conditions. She works in the Craniofacial and Craniofacial Genetics Clinic and the Limb Deп¬Ѓciency Clinic. She also serves as a genetics consultant in seven different outreach genetics clinics throughout the states of Washington and Alaska. She coordinates the craniofacial resident elective course and provides bedside teaching. She has served as Seattle Children’s principal investigator in a multicenter international study of the genetics of cleft lip and palate for the past six years. She is collecting pilot data for a future genetic study of sagittal synostosis using novel quantitative measures of head shape. Charlotte W. Lewis, MD, MPH, is attending physician at Seattle Children’s Hospital and assistant professor of pediatrics at the University of Washington School of Medicine. Her primary research interest is disparities 72 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON in health and health care access, with a speciп¬Ѓc focus on oral health and access to dental care. Her research has involved documenting disparities in access to oral health services for low-income and special needs children as well as developing and evaluating strategies to improve pediatric oral health through expanded pediatrician and family physician involvement in these areas. Wendy Mouradian, MD, MS, is clinical professor of pediatrics at the University of Washington, with adjunct appointments in pediatric dentistry, dental public health sciences and health services (at the School of Public Health). She is director of regional initiatives for the university School of Dentistry and has served as director of the craniofacial program at Seattle Children’s Hospital. Dr. Mouradian also heads the Oral-Systemic Theme Committee at the university School of Medicine, charged with integrating oral health into the curriculum of medical students. Dr. Mouradian earned her MD from Columbia University and her MS from the Massachusetts Institute of Technology. She completed a fellowship at the University of Washington. Dr. Mouradian has received several national awards for her role organizing and chairing The Face of a Child: Surgeon General’s Conference on Children and Oral Health; she was recognized by the American Dental Education Association for her efforts to advance the importance of oral health to the overall health of children. She is associate director of the Center for Leadership Education in Pediatric Dentistry. Her research areas include quality of life for children with craniofacial conditions, ethics and educational policy related to children’s oral health. Jacqueline R. Starr, PhD, MS, MPH, is epidemiologist at Seattle Children’s Hospital and research assistant professor of pediatrics and epidemiology at the University of Washington School of Medicine. She works full time in Seattle Children’s Craniofacial Center. Her primary research interests relate to identifying genetic variants that may contribute to the occurrence of craniofacial anomalies, with a particular focus on craniofacial microsomia. She also collaborates on research projects that broadly target the causes of craniofacial anomalies and the outcomes of clinical treatments for conditions such as cleft lip and palate. Craniofacial Medicine AWARDS AND HONORS Michael L. Cunningham, MD, PhD Jean Renny Endowed Chair in Pediatric Craniofacial Medicine, awarded 2005 Parent’s Choice Award, Seattle Children’s, 2005 Wendy Mouradian, MD, MS American Dental Education Association, Presidential Citation, 2005 Jacqueline R. Starr, PhD, MS, MPH Young Investigator Award, Seattle Children’s, 2005 RESEARCH FUNDING New Anne V. Hing, MD Homozygosity Mapping of Oculo-oto-facial Dysplasia, National Institute of Child Health and Human Development/NIH/DHHS, $65,932 Continuing Michael L. Cunningham, MD, PhD Dental and Orthodontic Access in Craniofacial Care, National Institute of Dental and Craniofacial Research, $157,930 Anne V. Hing, MD Genetics of Cleft Lip/Palate: A Multicenter International Consortium, University of Iowa, National Institute of Dental and Craniofacial Research, $52,716 Charlotte W. Lewis, MD, MPH Primary Care Provider and Preventive Oral Health, NIDCR/NIH, $125,959 TEACHING AND PRESENTATIONS Timothy C. Cox, PhD The Aetiopathology of Cleft Lip and Palate, Murdoch Children’s Research Institute, Parkville, Victoria, Australia, May 2005 Tissue Mosaicism for Respiratory Chain Deп¬Ѓciency in Mice Provides Evidence of Capacity of the Embryonic Heart to Remodel, symposium presentation, ComBio05, Adelaide, Australia, August 2005 Tissue Mosaicism for Respiratory Chain Deп¬Ѓciency in Mice Provides Evidence of Capacity of the Embryonic Heart to Remodel, International Congress of Developmental Biologists, Sydney, Australia, September 2005 What Determines the Severity of Clinical Presentation? and Novel Insights into Fetal and Adult Cardiac Health Revealed in a Unique Mouse Cardiomyopathy Model, Genetic Health Services Victoria, Parkville, Victoria, Australia, November 2005 Michael L. Cunningham, MD, PhD A Fourier-Based Approach for Quantifying Sagittal Synostosis Head Shape, American Cleft PalateCraniofacial Association (ACPA) annual meeting, Myrtle Beach, S.C., April 2005 Classifying Craniosynostosis Deformations from Skull Shape Imaging, Computer-Based Medical Systems (CBMS), The 18th IEEE Symposium, Dublin, Ireland, June 2005 TWIST Box Mutations, Sex-Related Asymmetries, and Rare FGFR and TWIST1 Sequence Variants in Single-Suture Craniosynostosis, American Society of Human Genetics, Salt Lake City, October 2005 A Symbolic Shape-Based Retrieval of Skull Images, American Medical Informatics Association, Washington, D.C., October 2005 Prevalence of Obstructive Sleep Apnea in the Craniofacial Clinic Population, Otolaryngology — Head & Neck Surgery, Los Angeles, September 2005 Cleft Lip and Palate; Craniosynostosis; Branchial Arch Anomalies and Plagiocephaly, housestaff teaching conferences, Seattle Children’s, 2005 Carrie L. Heike, MD, MS Craniofacial Features and TBX1 in 22q11 Deletion Syndrome, American Academy of Pediatrics Section on Genetics and Birth Defects Annual Meeting at the American Society of Human Genetics, Salt Lake City, October 2005 Syndromes Associated with Orofacial Clefts, housestaff teaching conference, Seattle Children’s, 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 73 Craniofacial Medicine Anne V. Hing, MD Fine Mapping of Two Genetic Loci for Nonsyndromic Cleft Lip, American Association of Dental Research, March 2005 A Fourier-Based Approach for Quantifying Sagittal Synostosis Head Shape, American Cleft PalateCraniofacial Association (ACPA) annual meeting, Myrtle Beach, S.C., April 2005 Novel Mutations in the TWIST Box Anti-Osteogenic Domain of TWIST1 Associated with Single-Suture Craniosynostosis, American Society of Human Genetics, 2005 Fine Mapping Candidate Genes in Cleft Lip Loci at 1p22-p33, 3q26-q28, 15q12-q14, and 17q12-31, American Journal of Human Genetics, 2005 Mirror Image Findings Noted on Three-Dimensional CT Scans of Monozygous Twins Concordant for Sagittal Synostosis, Northwest Genetics Exchange, Vancouver, BC, Canada Genetic Assessment of Craniofacial Anomalies, orthodontic resident lecture, Seattle Children’s, November 17, 2005 Charlotte W. Lewis, MD, MPH Maternal and Child Oral Health Institute Meeting, keynote speaker, HRSA-MCHB, Denver, November 2–3, 2005 Wendy Mouradian, MD, MS Oral Health for Montana’s Children and Families: What We Can Do Together, keynote address, Treasuring Montana’s Maternal and Child Health, Montana State — Spring Public Health Conference, Bozeman, Mont., May 2005 Whose Responsibility Is Children’s Oral Health?, keynote address, Royal Melbourne Children’s Hospital, Melbourne, Australia, Nov 2, 2005 The Importance of Oral Health in Children: Ethical and Social Issues, keynote address, International Association of Pediatric Dentistry, Sydney, Australia, Nov 3, 2005 74 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Jacqueline R. Starr, PhD, MS, MPH Adjusting for Potential Confounders via Propensity Scores: Mimicking Randomization Through Observational Studies?, University of Washington Dental Public Health Sciences, April 2005 Case-Control Versus Family-Based Approaches for Evaluating Maternal Genetic Effects, American Society for Human Genetics, Salt Lake City, October 25–29, 2005 Complications Within the First 24 Hours Following Cleft Lip Repair: A Justiп¬Ѓcation for Overnight Observation, American Cleft Palate-Craniofacial Association 62nd annual meeting, Myrtle Beach, S.C., April 2005 A Multicenter Study of Inter- and Intrarater Reliability in the Evaluation of Velopharyngeal Insufп¬Ѓciency, American Society of Pediatric Otolaryngology 20th annual meeting, Las Vegas, May 2005 PUBLICATIONS Collett B, Breiger D, King D, Cunningham M, Speltz M. Neurodevelopmental implications of “deformational” plagiocephaly. J Dev Behav Pediatr. Oct 2005;26(5):379–389. Edwards T, Patrick DM, Topolski T, Aspinall C, Mouradian W, Speltz M. Approaches to craniofacialspeciп¬Ѓc quality of life assessment in adolescents. Cleft Palate Craniofac. 2005;42(1):12–24. Heike CL, Cunningham ML, Steiner RD, Wenkert D, Hornung RL, Gruss JS, Gannon FH, McAlister WH, Mumm S, Whyte MP. Skeletal changes in epidermal nevus syndrome: does focal bone disease harbor clues concerning pathogenesis? Am J Med Genet A. Dec 1, 2005;139(2):67–77. Kapp-Simon KA, Leroux B, Cunningham M, Speltz ML. Multisite study of infants with single-suture craniosynostosis: preliminary report of presurgery development. Cleft Palate Craniofac J. Jul 2005;42(4):377–384 Lewis CW, Robertson A, Phelps S. Unmet dental care needs among children with special health care needs: implications for the medical home. Pediatrics. Sep 2005;116(3):e426–e431. Craniofacial Medicine Lewis CW, Ose M, Aspinall C, Omnell L. Community orthodontists and craniofacial care: results of a Washington state survey. Cleft Palate Craniofacial J. Sep 2005;42(5):521–525. Smith R, Lewis CW. Availability of dental appointments for young and Medicaid-insured children in King County Washington: implications for access. Pediatric Dentistry. May–Jun 2005;27(3):207–211. Lin HJ, Ruiz-Correa S, Sze RW, Cunningham ML, Speltz ML, Hing AV, Shapiro LG. Efп¬Ѓcient symbolic signatures for classifying craniosynostosis skull deformities. Lecture Notes in Computer Science. 2005;3765:302–313. So J, Suckow V, Kijas Z, Kalscheuer V, Moser B, Winter J, Baars M, Firth H, Lunt P, Hamel P, Meinecke P, Moraine C, Odent S, Schinzel A, van der Smagt JJ, Devriendt K, Albrecht B, Gillessen-Kaesbach G, van der Burgt I, Petrij F, Faivre L, McGaughran J, McKenzie F, Opitz JM, Cox TC, Schweiger S. Mild phenotypic spectrum in a series of Opitz BBB/G syndrome patients with MID1 mutations. Am Med Genet. 2005;132A:1–7. McGillivray G, Savarirayan R, Cox TC, Stojkoski C, McNeil R, Bankier A, Bateman JF, Rosciolo T, Gardner RJM, Lamande SR. Familial scaphocephaly syndrome caused by a novel mutation in the FGFR2 tyrosine kinase domain. Med Genet. 2005;42:656–662. Mouradian W, Reeves A, Evans R, Kim S, Schaad D, Marshall S, Slayton R. Oral health curriculum for medical students at the University of Washington. Acad Med. 2005;80:434–442. Parashar SY, Anderson PJ, Cox TC, McLean N, David DJ. Multidisciplinary management of Opitz GBBB syndrome. Annals of Plastic Surgery. 2005;55:402–408. Pollack PS, Shields KE, Burnett DM, Osborne MJ, Cunningham ML, Michael E, Stepanavage ME. Pregnancy outcomes after maternal exposure to simvastatin and lovastatin. Birth Defects Res A Clin Mol Teratol. Nov 2005;73(11):888–896. Ratisoontorn C, Cunningham ML. Saethre-Chotzen syndrome. In: GeneReviews at GeneTests: Medical Genetics Information Resource. Seattle: University of Washington, January 3, 2005; e-publication. Ratisoontorn C, Seto ML, Broughton KM, Cunningham ML. In-vitro differentiation proп¬Ѓle of osteoblast derived from patients with Saethre-Chotzen syndrome. Bone. Apr 2005;36(4):627–634. Slavotinek A, Parisi M, Heike C, Hing A, Huang E. Craniofacial defects of blastogenesis: duplication of pituitary with cleft palate and oropharyngeal tumors. Am Med Genet, Part A. May 15, 2005;135(1):13–20. Starr JR. The relative contribution of oral cancer risk factors may differ in younger as compared to older adults. J Evidence-Based Dent Pract. 2005;5:78–79. Starr JR, Chen C, Doody DR, Hsu L, Ricks S, Weiss NS, Schwartz SM. Risk of testicular germ cell cancer in relation to variation in maternal and offspring cytochrome p450 genes involved in catechol estrogen metabolism. Cancer Epidemiol Biomarkers Prev. 2005;14:2183–2190. Starr JR, Hsu L, Schwartz SM. Performance of the log-linear approach to case-parent triad data for assessing maternal genetic associations with offspring disease: type I error, power, and bias. Am J Epidemiol. 2005;161:196–204. Starr JR, Hsu L, Schwartz SM. Assessing maternal genetic associations: a comparison of the log-linear approach to case-parent triad data and a case-control approach. Epidemiology 2005;16:294–303. Sze RW, Hopper RA, Ghioni V, Gruss JS, Ellenbogen RG, King D, Hing AV, Cunningham ML. MDCT diagnosis of the child with posterior plagiocephaly. Am J Roentgenol. Nov 2005;185(5):1342–1346. Yeung LC, Cunningham ML, Allpress AL, Gruss JS, Ellenbogen RG, Zerr DM. Surgical site infections following pediatric intracranial surgery for craniofacial malformations: frequency and risk factors. Neurosurgery. Apr 2005;56(4):733–739. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 75 Critical Care Medicine The Division of Critical Care Medicine (in the Department of Pediatrics) delivers comprehensive, state-of-the-art critical care medicine focused in three clinical arenas: cardiac intensive care at Seattle Children’s Hospital, medical-surgical intensive care at Seattle Children’s and trauma intensive care at Harborview Medical Center. Children’s Pediatric Intensive Care Unit (PICU) represents an epicenter for a number of highprofile Children’s programs, including the Heart Center, Seattle Cancer Care Alliance, solid organ transplantation, neurosurgery, craniofacial surgery, hematology/oncology, Airlift Northwest and a range of extracorporeal life-support technologies. With a “right care right now” attitude, 12 critical care medicine faculty and seven fellows oversee all care in the University of Washington PICUs. Several crucial concepts first evolved within Children’s PICU, including family-centered care, formal quality-improvement and patientsafety initiatives, computerized physician order entry (CPOE), severity of illness risk-adjusted outcomes analysis and innovative infection control programs. Children’s PICU received a design award from the Society of Critical Care Medicine and the American Institute of Architecture, and serves as a family-friendly, safe haven for critically ill children in the WAMI region (Washington, Alaska, Montana, Idaho). Critical care medicine faculty are involved in clinical, research, teaching and service activities within Children’s Department of Pediatrics, Harborview Medical Center and the University of Washington. Despite the very high clinical acuity and activity involved in intensive care training, critical care medicine fellows all participate in basic, translational/ clinical or outcomes research with an expectation of an academic career following fellowship training. TEACHING, RESEARCH AND CLINICAL EXPERTISE Jerry J. Zimmerman, MD, PhD, is chief of the Division of Critical Care Medicine and director of the Pediatric Intensive Care Unit at Seattle Children’s Hospital. He is professor of pediatrics and anesthesiology at the University of Washington School of Medicine. Dr. Zimmerman has been chair of the Scientiп¬Ѓc Advisory Committee for Children’s Hospital Clinical Research Center since its inception. He is a member of the Society of Critical Care Medicine and a charter member of the American College of Critical Care Medicine. With Bradley Fuhrman, Zimmerman is co-editor of the current premier textbook for the п¬Ѓeld, Pediatric Critical Care. Additionally, Zimmerman serves on the editorial boards for Critical Care Medicine and Pediatric Critical Care Medicine, and is book review editor for both journals. He also provides ad hoc review for a number of other journals. Dr. Zimmerman is interested in the disequilibrium between the systemic inflammatory response syndrome and compensatory anti-inflammatory response syndrome that occurs as an important 76 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON aspect of pathophysiology in critical illness. He is particularly interested in the integrated role of neurological, endocrinologic and inflammatory cross-talk, particularly involving reactive oxygen species and fatty acid–derived mediators and their effect on metabolism. Dr. Zimmerman was chosen as a charter principal investigator for the recently established Collaborative Pediatric Critical Care Research Network. Harris P. Baden, MD, is director of the Cardiac Intensive Care Program at Seattle Children’s Hospital and director of the Pediatric Critical Care Medicine Fellowship Program. Dr. Baden has served in similar capacities in the Department of Pediatrics at Northwestern University Medical School in Chicago. He completed his fellowship training in the Department of Anesthesiology at Seattle Children’s in 1995. Dr. Baden serves on the ICU Leadership Committee, the hospital Quality Improvement Steering Committee, and is medical director of the Point of Care Testing Program for the hospital. His clinical, teaching and research interests relate to pediatric cardiac intensive care and medical education. Critical Care Medicine Thomas V. Brogan, MD, is attending physician at Seattle Children’s Hospital and Harborview Medical Center and associate professor of pediatrics at the University of Washington School of Medicine. He completed a residency in pediatrics and a fellowship in pediatric critical care medicine. Dr. Brogan has published a number of peer-reviewed articles and several chapters with an emphasis on respiratory physiology. He has also published a number of articles related to pediatric critical care including studies on mechanical ventilation, necrotizing fasciitis and extracorporeal membrane oxygenation (ECMO). Dr. Brogan’s laboratory-based research centers on pulmonary blood flow, the effects of carbon dioxide on changes in pulmonary blood flow and the matching of ventilation to pulmonary blood flow. He has been a collaborating researcher on several research projects. He also serves as reviewer for a number of medical journals. In addition to his research he has served as director of extracorporeal support services at Children’s since 2001. He is also serves as a member of the Airlift Landing Review Committee. Michael P. Davis, MD, is assistant professor of pediatrics at Seattle Children’s Hospital and medical director of the PICU at Harborview Medical Center. He completed his residency at the University of Maryland and a fellowship in critical care at Seattle Children’s. In addition to providing clinical care he serves on multiple committees including the Blood Utilization and Transplant committees at Children’s, and the Trauma Council and the ICU Steering Committee at Harborview. His clinical research involves designing and implementing a database of all solid organ transplant patients at Children’s for outcomes research. He has special interest in education and is responsible for resident education in the PICU; he is also a member of the resident education subcommittee of the Society FACULTY Jerry J. Zimmerman MD, PhD, Director Jerry J. Zimmerman, MD, PhD, Director Harris P. Baden, MD Thomas V. Brogan, MD Michael P. Davis, MD David S. Jardine, MD, Howard E. Jeffries, MD, MPH, MBA Robert Mazor, MD of Critical Care Medicine. Dr. Davis is responsible for quality improvement measures in the PICU at Harborview as well. David S. Jardine, MD, attends in anesthesiology and critical care at Seattle Children’s Hospital and pediatric critical care at Harborview Medical Center, and he is associate professor of anesthesiology and pediatrics. He completed residencies in pediatrics and anesthesiology, and a fellowship in pediatric anesthesiology and intensive care. He has published numerous chapters and peer-reviewed articles, with an emphasis on hemorrhagic shock and encephalopathy syndrome, which is a special interest of his. His laboratory-based research interests are in using heat shock proteins as biomarkers and in examining the protective effect of heat shock proteins during brain injury. He has been principal investigator on a number of grants. Other interests include medical stafп¬Ѓng issues; he helped formulate and interpret a recent American Academy of Pediatrics survey on pediatric intensive care stafп¬Ѓng needs. He has served as a reviewer for a variety of medical journals. He serves on the Institutional Review Board at Seattle Children’s and on the research committee for the Department of Anesthesiology. He serves on the board of the SIDS Foundation of Washington and is incoming president for 2007. Howard E. Jeffries, MD, MPH, MBA, is clinical assistant professor of pediatrics and attending physician at Seattle Children’s Hospital. He completed a residency in pediatrics and a fellowship in pediatric intensive care. Dr. Jeffries is director for quality improvement for critical care services. He has published chapters and peer-reviewed articles, with an emphasis on cardiac intensive care, informatics and quality improvement. He sits on the advisory board for the Virtual PICU and has played an active role in the development of a national cardiac John K. McGuire, MD Joan S. Roberts, MD ICU database. Other Kenneth A. Schenkman, interests include health MD, PhD care п¬Ѓnance, billing and compliance issues. He serves on the Children’s University Medical Group (CUMG) Physician Education and Compliance Committee, the University of SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 77 Critical Care Medicine Washington CUMG Retirement & Beneп¬Ѓts Committee, the Children’s Hospital Pharmacy & Therapeutics Committee, the Infection Control Committee, and the Nutrition Committee. Robert Mazor, MD, is assistant professor of pediatrics and attending physician in the cardiac ICU at Seattle Children’s Hospital. He completed a residency in pediatrics and fellowships in pediatric critical care medicine and pediatric cardiology. Dr. Mazor has an interest in congenital heart disease and mechanical circulatory support. He also has a special interest in education, serving as the educational coordinator for fellow and resident cardiac critical care electives. He has been selected to participate in the University of Washington’s Teaching Scholars program. John K. McGuire, MD, is assistant professor of pediatrics and attending physician in the PICUs at Seattle Children’s Hospital and Harborview Medical Center. Dr. McGuire earned his MD from Northwestern University and trained in general pediatrics and pediatric critical care medicine at Children’s Memorial Hospital and Northwestern University in Chicago. He worked at Washington University in St. Louis. He is board certiп¬Ѓed in general pediatrics and pediatric critical care medicine and is a member of several academic societies including the American Thoracic Society and the American Society for Matrix Biology. Dr. McGuire is a member of the University of Washington Center for Lung Biology. His laboratory work is directed at understanding how epithelial responses to acute injury regulate repair and contribute to tissue п¬Ѓbrosis and chronic organ dysfunction. Using complementary cell and mouse-based models of human disease, Dr. McGuire’s research focuses on the function of matrix metalloproteinases (MMPs) in acute lung injury and acute renal tubular injury. Related projects are focused on elucidating the role of MMPs in viral and bacterial lung infections. Dr. McGuire serves as a member of the Accreditation Council for Graduate Medical Education Board of Appeals Panel for Pediatrics. Joan S. Roberts, MD, is assistant professor of pediatrics and attending physician in the PICUs at Seattle Children’s Hospital and Harborview Medical Center. Dr. Roberts earned her MD at the University of Nevada. She did her pediatrics residency at Seattle Children’s and served as chief resident; she completed her critical care training at Seattle Children’s. 78 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Dr. Roberts has authored more than two dozen scientiп¬Ѓc manuscripts and abstracts. She has been Children’s representative to the national Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. She is interested in clinical outcomes research and in decreasing time needed for mechanical ventilation in sick children with lung disease and asthma. Dr. Roberts is director of the Children’s Hospital Mock-Code Team, and also chairs the Hospital Code Committee. Kenneth A. Schenkman, MD, PhD, is attending physician in the PICUs at Seattle Children’s Hospital and Harborview Medical Center; he is associate professor of pediatrics and anesthesiology and adjunct associate professor of bioengineering at the University of Washington School of Medicine. He is director of critical care medicine research at Seattle Children’s. Dr. Schenkman received his MD from Indiana University and completed a pediatric residency at the Children’s Hospital of Pittsburgh, where he also served as chief resident. He trained in pediatric critical care at Seattle Children’s and received a PhD in bioengineering from the University of Washington. He has an active research program developing optical spectroscopic technologies for clinical assessment of intracellular oxygenation and mitochondrial function. Dr. Schenkman has been awarded a US patent for his pioneering work on developing an intracellular oxygen monitor. Dr. Schenkman has published dozens of manuscripts and abstracts in the п¬Ѓeld of optical spectroscopy for physiologic and clinical applications, and has published several book chapters on pediatric critical care topics. He also has been an active reviewer for journals in the п¬Ѓelds of medicine, physiology and engineering. AWARDS AND HONORS Jerry J. Zimmerman, MD, PhD Listed in “Best Doctors in America,” 2005 RESEARCH FUNDING New David S. Jardine, MD BCL2 Inducible Transgenic Mouse Development Project, Texas A&M/NIH, $75,800 Critical Care Medicine Kenneth A. Schenkman, MD, PhD Modeling of Cardiac Transport, Medical College of Wisconsin/NIH, $73,304 Continuing Kenneth A. Schenkman, MD, PhD Mitochondrial Function by Optical Spectroscopy 2, Whitaker Foundation, $80,000 Jerry J. Zimmerman, MD, PhD Investigation of the Efп¬Ѓcacy and Safety of Drotrecogin Alfa (Activated) in Pediatric Severe Sepsis, Eli Lilly & Co, Lilly Research Laboratories, $52,815 1st Tier Drugs В± Theophylline in Pediatric Severe Asthma, National Institute of Child Health and Human Development/NIH/DHHS, $367,311 TEACHING AND PRESENTATIONS Harris P. Baden, MD Blue Baby, White Knuckles, resident noon lecture, Seattle Children’s, 2005 Thomas V. Brogan, MD Shock States in the Children, Madigan Pediatric Department, November 2005 Howard E. Jeffries, MD, MPH, MBA Arrhythmias in the PICU, pediatric resident PICU lecture, Seattle Children’s, 2005 ECLS Equipment, ECMO training coursework, Seattle Children’s, 2005 Quality improvement in critical care lecture series, multidisciplinary quality improvement conference, Seattle Children’s, 2005 ECLS, PCCM lecture, Seattle Children’s, 2005 What Can Go Wrong, Will Go Wrong: The Interface of Humans and Technology, patient safety conference, Seattle Children’s, 2005 Pulmonary Hypertension in the PICU, PICU nursing education day, Seattle Children’s, 2006 Balancing Qp & Qs in the Postoperative Norwood Patient, PICU nursing education day, Seattle Children’s, 2005 Robert Mazor, MD Pulmonary Hypertension, PICU RN core classes, March 2005 Palliation of the Single Ventricle Patient, CICU RN orientation, October 2005 Inlets and Outlets of Congenital Heart Disease, resident noon conference, October 2005 John K. McGuire, MD Matrix Metalloproteinases in Epithelial Injury: A Role for MMP-7 in Inflammation and Re-epithelialization, European Tissue Repair Society, Stuttgart, Germany, 2005 Jerry J. Zimmerman, PhD, MD Steroids in Pediatric Sepsis: The Good and the Bad, Society of Critical Care Medicine 2005 Congress, Phoenix, January 15–19, 2005 Medicine faculty development leadership course, University of Washington, February 15–16, 2005 Update on Pediatric Critical Care Research, Pro/Con Debate: Tight Glucose Control Should be Implemented in the PICU (con position) and 2004 Year in Review— How the Current Literature May Change My Practice, Second Annual Canadian Critical Care Conference, Whistler, BC, February 23–26 Fluid Therapy in Pediatric Critical Care Medicine, Blood Component Therapy in Pediatric Critical Care Medicine, Role of the Endothelium in Sepsis Pathophysiology, Contemporary Treatment of Sepsis, Case Presentation: A Teenager with Fever and Coma, Case Presentation: An Infant with Seizures, URI and Diarrhea, SimpГіsio Internacional de Terapia Intensiva PediГЎtrica e Cirurgia CardГaca, Rio de Janeiro, Brazil, March 10–12, 2005 How to Mend a Broken Heart, pediatric resident noon conference, Seattle Children’s, 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 79 Critical Care Medicine Update on Sepsis Research, Contemporary Treatment of Pediatric Sepsis and Activated Protein C in Sepsis, Sepsis Case Discussant, Pediatric Sepsis Update, Indian Society of Critical Care Medicine, Pediatric Section, Apollo Centre for Advanced Pediatrics — ACAP. New Delhi, India, April 16, 2005 Septic Shock — Fine Tuning the Management, Status Asthmaticus — My Management Approach and Workshop on Managing Mechanical Ventilation, Critical Care Pediatrics, Indian Academy of Pediatrics, Nagpur, India, April 17, 2000 A Brief Introduction to ECLS, ECLS training course, Seattle, July 6, 2005 Pediatric Acute Lung Injury and Sepsis Investigators (PALISI), Sixth International Meeting, Montreal, September 21–24, 2005 Surrogate Endpoints in Pediatric Critical Care Medicine Research; Mouvement en Г‰pidГ©miologie et Recherche Clinique; Stress Dose Steroids as Adjunctive Therapy for Pediatric Severe Sepsis; and visiting professor, Sainte-Justine Hospital, University of Montreal, Department of Pediatrics Grand Rounds, September 21, 2005 PUBLICATIONS Baden HP. Does Nesiritide offer something new in the management of pediatric heart failure? Ped Crit Care Med. 2005;6(5):613–614. Cengiz P, Brogan TV, Roberts JS. Central nervous system complications during pediatric extracorporeal life support: incidence and risk factors. Crit Care Med. 2005;33(12):2817–2824. 80 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Ciesielski WA, Arakaki LSL, Schenkman KA. Temperature and pH effects on myoglobin optical absorbance spectra. Proceedings of the SPIE International Symposium on Biomedical Optics. 2005;(4)5702–5727. Curley MAQ, Zimmerman J. Alternative outcome measures for pediatric clinical sepsis trials. Pediatr Crit Care Med. 2005;6:S150–S156. Ejike JC, Arakaki LSL, Beard DA, Ciesielski WA, Feigl EO, Schenkman KA. Myocardial oxygenation and adenosine release in isolated guinea pig hearts during changes in contractility. Am J Physiol Heart Circ Physiol. 2005;288(5):H2062–H2067. Garrison M, Jeffries H, Christakis D. Risk of death for children with Down syndrome and sepsis. J Pediatr. 2005;147:748–752. Lupu LA, Roberts JS, Seidel K. Surfactant therapy in ECMO patients. Proceedings of the American Thoracic Society. 2005;2:252. Marcinek DJ, Schenkman KA, Ciesielski WA, Lee D, Conley KE. Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle. J. Physiol. 2005;569(2):467–473. Markovitz BP, Goodman DM, Watson RS, Bertock D, Zimmerman J. A retrospective study of prognostic factors associated with outcome in pediatric severe sepsis: what is the role of steroids? Pediatr Crit Care Med. 2005;6:270–274. McGuire JK. Adhesion, cell-cell: epithelial. In: Encyclopedia of Respiratory Medicine. Laurent GJ, Shapiro SD, eds. Oxford: Elsevier, 2005. Emergency Medicine The Division of Emergency Medicine (in the Department of Pediatrics) is a 24-hours-per-day, 365-days-per-year operation. The emergency division provides specialized expertise in management of urgent, emergency and critical medical and surgical issues. Emergency Medicine is dedicated to premier, up-to-date, consistent and efficient pediatric care in a family-centered environment. The Emergency Department (ED) is actively redefining and refining its operation, standards and facilities to ensure highest quality and optimal practice. The Emergency Department treats approximately 31,000 patients per year, with half of all patients admitted to Seattle Children’s being cared for initially in the ED setting. The department is a center for education in the acute management of ill and injured infants, children and adolescents to age 21. Over 120 residents train in our division each year, from the University of Washington pediatric training program and multiple family medicine and emergency medicine programs, as well as medical, nursing and paramedic students. This experience includes a didactic curriculum and significant hands-on training. Faculty also participate actively in local, regional, national and international teaching endeavors. The division sponsors a fellowship program with four fellows enrolled. Division faculty include 14 faculty positions and 19 clinical pediatric physicians. Faculty physicians hold leadership positions in local and university activities outside the division and are active in state and national organizations in membership and leadership positions. Faculty are active in clinical research, focusing on education, infectious diseases, injury management, injury prevention, informatics, quality, respiratory illness, resuscitation, safety and sedation; and division research includes several interdisciplinary projects. TEACHING, RESEARCH AND CLINICAL EXPERTISE George A. (Tony) Woodward, MD, MBA, is director of the Division of Emergency Services at Seattle Children’s Hospital and professor of pediatrics at the University of Washington School of Medicine. He is director for Transport Medicine at Seattle Children’s. He received his MD from Temple University Medical School and his MBA from The Wharton School at the University FACULTY George A. (Tony) Woodward MD, MBA, Director George A. (Tony) Woodward, MD, MBA, Director Julie C. Brown, MD, MPH Dena R. Brownstein, MD Brian H. Coleman, MD, MS Mark A. Del Beccaro, MD Douglas S. Diekema, MD, MPH Ron L. Kaplan, MD Eileen J. Klein, MD, MPH Suzan S. Mazor, MD of Pennsylvania. He completed an internship and residency at St. Christopher’s Hospital for Children in Philadelphia and a fellowship at the pediatric emergency medicine program at Children’s Hospital of Philadelphia. He held faculty positions at the University of Pennsylvania School of Medicine and Primary Children’s Medical Center in Salt Lake City. Dr. Woodward is a member of the Children’s University Medical Group (CUMG) Board of Directors. He has been awarded the Norcliffe Foundation Endowed Chair in Pediatric Emergency Russell T. Migita, MD Medicine and has been Carolyn A. Paris, MD, MPH elected as a member for Linda Quan, MD Richard P. Shugerman, MD the American Pediatric Paige L. Wright, MD, MS Society — Society for Pediatric Research. Dr. Woodward’s specialty and board certiп¬Ѓcations include being an ACLS provider, an ATLS provider, and being certiп¬Ѓed as a Pediatric Education SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 81 Emergency Medicine for Prehospital Professionals (PEPP) provider and instructor. Dr. Woodward has held several editorial positions and authored numerous publications. Julie C. Brown, MD, MPH, is emergency attending physician at Seattle Children’s Hospital and assistant professor at the University of Washington School of Medicine. She received her MD from McGill University, Montreal, an MHSc from the University of British Columbia, Vancouver, and her MPH from the University of Washington. She completed her residency and pediatric emergency medicine fellowship at Seattle Children’s. She is board certiп¬Ѓed in general pediatrics and pediatric emergency medicine by the American Board of Pediatrics. She is a member of the American Academy of Pediatrics and the Ambulatory Pediatric Association. She was principal investigator for research on a new model for asthma care in the emergency department. She has also been co-investigator on research in handheld technology in ADHD care, a computerized asthma management system (CAMS) and pediatric evidence-based medicine (EMB.) Dena R. Brownstein, MD, is emergency attending physician at Seattle Children’s Hospital and associate professor at the University of Washington School of Medicine. She is quality improvement coordinator in the Department of Medicine at Seattle Children’s. She received her MD from the University of Washington; she completed her residency at Seattle Children’s and a fellowship in pediatric emergency medicine at Children’s Hospital of Philadelphia. She is board certiп¬Ѓed in general pediatrics and pediatric emergency medicine by the American Board of Pediatrics and is a diplomate of the National Board of Medical Examiners. Dr. Brownstein is coordinator of the University of Washington’s internship for paramedic students and paramedic course director. She is co-chair of the American Academy of Pediatrics National Pediatric Education for Prehospital Professionals (PEPP) Steering Committee and a member of the American Academy of Pediatrics — Emergency Medical Services for Children Subcommittee of Quality Indicators. Dr. Brownstein is a member of regional and national organizations and is the recipient of numerous awards including the University of Washington Outstanding Public Service Award Dr. Brownstein was co-investigator on research for the Developmental Center for Education and Research in Pediatric Safety. 82 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Brian H. Coleman, MD, MS, is emergency attending physician at Seattle Children’s Hospital and assistant professor at the University of Washington School of Medicine. He received his MD from the University of Florida College of Medicine, Gainesville, Fla. and his MS in epidemiology from the University of Washington School of Community Health and Public Medicine. He completed his residency at Shands Hospital in Gainesville and a fellowship in pediatric emergency medicine at Seattle Children’s. He is a diplomate of the American Board of Pediatrics and the National Board of Medical Examiners. He is a member of the American Academy of Pediatrics and its Section on Emergency Medicine. He was principal investigator for research on serum phosphate and venous lactate in children with intussusception. Mark A. Del Beccaro, MD, is emergency attending physician at Seattle Children’s Hospital and professor at the University of Washington School of Medicine. He is associate director of the emergency department, clinical director of information services and chair of the medical informatics/medical records committee at Seattle Children’s. He received his MD from the University of Washington and his MS in epidemiology from the University of Washington School of Community Health and Public Medicine. He completed his residency at Seattle Children’s and the certiп¬Ѓcate program in medical management at the University of Washington. Dr. Del Beccaro is board certiп¬Ѓed in general pediatrics and pediatric emergency medicine by the American Board of Pediatrics, and he is certiп¬Ѓed by the American Heart Association in ACLS , PNALS and PALS. He is a member of many regional and national associations. He is sought after nationally as a speaker on the subject of medical informatics and has an extensive bibliography. Douglas S. Diekema, MD, MPH, is emergency attending physician and interim director of the Treuman Katz Center for Pediatric Bioethics at Seattle Children’s Hospital and associate professor at the University of Washington School of Medicine. He received his MD from the University of North Carolina School of Medicine and his MPH from the University of Washington School of Public Health. He completed his residency at the University of Wisconsin Hospital and Clinics in Madison. He is board certiп¬Ѓed in general pediatrics and pediatric emergency medicine by the American Board of Pediatrics. He is a member of several medical Emergency Medicine organizations. His teaching responsibilities include education in the emergency department, monthly pediatric ethics conferences and several education committees. He has been a visiting professor throughout the WAMI region (Washington, Alaska, Montana, Idaho). He is sought after as a lecturer nationally. He has numerous local and national committee responsibilities, as well as an extensive bibliography. He is principal investigator for a research grant on bioethics in health care and research. Ron L. Kaplan, MD, is emergency attending physician at Seattle Children’s Hospital and clinical assistant professor at the University of Washington School of Medicine. He received his MD with highest honors from the University of North Carolina School of Medicine. He completed his residency at the University of North Carolina Hospitals and a fellowship in pediatric emergency medicine at Children’s Hospital Boston. He is board certiп¬Ѓed in general pediatrics and pediatric emergency medicine by the American Board of Pediatrics. His teaching responsibilities include education in the emergency department and monthly didactic sessions with the Seattle Children’s housestaff. He is involved in the research project Clinical Decision Rule for Identifying Children with Cerebrospinal Fluid Pleocytosis at Very Low Risk for Bacterial Meningitis. Eileen J. Klein, MD, MPH, is emergency attending physician at Seattle Children’s Hospital and associate professor at the University of Washington School of Medicine. She is emergency medicine fellowship director at Seattle Children’s. She received her MD from Johns Hopkins School of Medicine and her MPH in epidemiology from the University of Washington School of Public Health. She completed her residency and a fellowship in pediatric emergency medicine at Seattle Children’s. She is a fellow of the American Academy of Pediatrics, and a member of the Ambulatory Pediatric Association and American College of Emergency Physicians. She is board certiп¬Ѓed in general pediatrics and pediatric emergency medicine by the American Board of Pediatrics, and she is certiп¬Ѓed by the American Heart Association in ACLS, ATLS and PALS. Dr. Klein is part of the Teaching Scholars program at the university School of Medicine, and she trains pediatric emergency medicine fellows and regularly teaches locally and regionally. Her recent research as principal investigator includes the projects Diarrhea Etiology and Risk Factors Study, and Emergency Department Research Collaboration. She was also an investigator on the study Center for Evaluation and Research in Public Safety. She has an extensive bibliography. Suzan S. Mazor, MD, is emergency attending physician at Seattle Children’s Hospital and assistant professor at the University of Washington School of Medicine. She is pediatric emergency medicine fellowship director at Seattle Children’s. She received her MD from University of Illinois at Chicago. She completed her residency at Children’s Hospital Medical Center in Cincinnati, Ohio, a fellowship in pediatric emergency medicine at Children’s Memorial Hospital, Chicago and a fellowship in medical toxicology at Toxikon Consortium, John H. Stroger Hospital of Cook County, Chicago. Dr. Mazor is associate medical director of the Washington Poison Control Center in Seattle. She is a member of the American College of Medical Toxicology, American Board of Pediatrics, Ambulatory Pediatric Association and the Section on Emergency Medicine of the AAP. She is a diplomate of the American Board of Medical Toxicology, Pediatric Emergency Medicine, American Board of Pediatrics and National Board of Medical Examiners. Russell T. Migita, MD, is emergency attending physician at Seattle Children’s Hospital and assistant professor at the University of Washington School of Medicine. He received his MD from University of California, San Diego School of Medicine. He did his internship, residency and fellowship at the University of Washington. Dr. Migita has received certiп¬Ѓcation from the American Board of Pediatrics and is a certiп¬Ѓed PALS provider and instructor, ATLS provider and NRP provider. His special responsibilities include membership on Children’s Pharmacy and Therapeutics Committee, Emergency Department Night Float Committee, Emergency Department Education Committee and participation on the Ambulatory Referral Process Management Guidance Team, Emergency Department Rapid Process Improvement Management Guidance Team and Emergency Department CME Course Planning Committee. Dr. Migita has received the University of Washington Fellow Teaching Award. Carolyn A. Paris, MD, MPH, is emergency attending physician at Seattle Children’s Hospital and assistant professor at the University of Washington. She received her MD from Cornell University Medical College and SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 83 Emergency Medicine her MPH in epidemiology from the University of Washington School of Public Health. She completed a residency at Harbor–UCLA Medical Center and a fellowship at Seattle Children’s. She is board certiп¬Ѓed and licensed through the National Board of Medical Examiners in Pediatrics and the American Heart Association. Dr. Paris is a member of the American Academy of Pediatrics and the Ambulatory Pediatric Association. Her local responsibilities include Seattle Children’s Fellowship Committee, adverse events monitoring for JDRF Study of Autoimmunity and the University of Washington Faculty Senate. She is ad hoc reviewer for the journals Acta Paediatrica, Pediatrics and Pediatric Emergency Care. Dr. Paris also has an interest in research. Her extensive bibliography includes her latest study, Search for Diabetes in Youth. Linda Quan, MD, is emergency attending physician at Seattle Children’s Hospital and professor in the Department of Pediatrics at the University of Washington School of Medicine. She received her MD from the University of Washington School of Medicine, where she trained as an intern, resident and fellow. She was chief of emergency services at Seattle Children’s for more than two decades. Dr. Quan is board certiп¬Ѓed by the American Board of Pediatrics in emergency medicine. She is a member of many committees for the American Academy of Pediatrics, American Heart Association, National Emergency Medical Services for Children Data Analysis Resource Center (NEDARC), Emergency Medical Services for Children (EMS-C) and CDC Injury Prevention Centers. She has spent a large part of her career on research, spearheading a large list of biomedical research grants. Dr. Quan has received numerous awards and has an extensive bibliography. directly in teaching committees for every service through which residents rotate in three local hospitals and four regional practices. Dr. Shugerman is active on several regional and national committees and has published extensively. Paige Wright, MD, MS, is emergency attending physician at Seattle Children’s Hospital and assistant professor at the University of Washington School of Medicine. She received her MD from Indiana University School of Medicine and her MS in clinical investigation from Northwestern University. She was clinical instructor in pediatrics at Northwestern University School of Medicine. She completed a residency and a fellowship at Children’s Memorial Hospital in Chicago. Dr. Wright is a diplomate of the American Board of Pediatrics, and she is certiп¬Ѓed as an ATLS provider and a PALS provider; she is also a PALS instructor. Dr. Wright is a member of the American Academy of Pediatrics. AWARDS AND HONORS Linda Quan, MD Listed in “Best Doctors 2005,” Seattle magazine RESEARCH FUNDING New Douglas S. Diekema, MD, MPH Promoting Pediatric Bioethics in Health Care and Research, Maternal and Child Health Bureau/Health Resources and Services Administration/DHHS, $337,280 Continuing Richard Shugerman, MD, is emergency attending physician at Seattle Children’s Hospital and associate professor in the Department of Pediatrics at the University of Washington School of Medicine. He is director of the pediatric residency program at the University of Washington. He received his MD from the University of Alabama School of Medicine in Birmingham and completed an internship and a residency in pediatrics at the University of Washington. Dr. Shugerman is board certiп¬Ѓed in pediatrics by the American Board of Pediatrics and certiп¬Ѓed by the American Heart Association as a PALS provider. As director of pediatric residency, his responsibility is leading the education of 72 pediatric residents; he leads and participates 84 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Eileen J. Klein, MD, MPH Diarrhea Etiology and Risk Factor Study, Washington University of St. Louis, $838,390 PRESENTATIONS AND TEACHING ACTIVITIES Mark A. Del Beccaro, MD EMR Implementation: Strategies and Lessons Learned, Mercy Children’s Hospital, Kansas City, Mo., February 2005 CPOE Implementation, Washington Patient Safety Coalition, Seattle, May 2005 Emergency Medicine Dena Brownstein, MD Beyond Stories: Engaging Physicians as Change Agents for Patient Safety, NCHRI, New Orleans, spring 2005 Douglas Diekema, MD, MPH Family Presence at Resuscitation and Sodium Bicarbonate in Tricyclic Anti-Depressant Overdose, Calcium-Channel Blocker Overdose, Hypermagnesemia, and Prolonged Pediatric Resuscitation, International Consensus on ECC & CPR Science with Treatment Recommendations 2005, Dallas, January 23–27, 2005 Everyday Ethics, National Pediatric Emergency Fellows Retreat, Los Angeles, March 5–7, 2005 Pediatric Advanced Life Support Course, Bartlett Memorial Hospital, Juneau, Alaska, April 19–20, 2005 Approaching Moral Problems: A Primer in Ethics; Introduction to Family-Centered Ethics; Unreasonable Parent Demands; Foregoing Nutrition and Hydration, 4th Forum on Perinatal/Neonatal Ethical Issues, Colorado Springs, Colo., May 11–13, 2005 How Cozy Is Too Cozy: Pharmaceutical Companies and the Pediatrician, Pediatric Academic Societies annual meeting, Washington, D.C., May 15, 2005 What Brain Science Can Teach Us About Ethics Education and Into the Future: New Strategies for Teaching Bioethics, Pediatric Ethics: Setting an Agenda for the Future, Cleveland, September 9–11, 2005 Eyes Wide Open: The Good Physician Meets the Pharmaceutical Industry, Cincinnati Pediatric Society Lyon Memorial Lecture/Pediatric Grand Rounds for Cincinnati Children’s Hospital Medical Center, Cincinnati, October 4, 2005 Eileen J. Klein, MD, MPH Catastrophic Illness, Pediatric Advanced Life Support renewal course, Seattle Children’s, January 28, 2005 Febrile Seizures and Toxicology — What You Don’t Need to Worry About, Great Falls Clinic, Great Falls, Mont., June 6, 2005 Shock, Pediatric Advanced Life Support course, Seattle Children’s, June 20, 2005 Status Epilepticus, Pediatric Advanced Life Support course, Seattle Children’s, November 4, 2005 Suzan Mazor, MD Delayed Toxic Syndrome and Cyanide and Fumigants, Agency for Toxic Substances & Disease Registry/American College of Medical Toxicology, Chemical Weapons of Convenience and Opportunity course, Seattle, September 2005 Carolyn Paris, MD, MPH Dental Manifestations of Medical Disorders in Children, University of Washington Medical School, May 2005 Linda Quan MD Biphasic Wave Dosing in the Pediatric Patient; Age-Based vs. Etiology-Based Approach to CPR, 2005 International Consensus on ECC and CPR Science with Treatment Recommendations, Dallas, January 23–39, 2005 George A. Woodward, MD, MBA Pediatric Critical Care Transport, Paciп¬Ѓc Region EMSC Partnership Symposium, Seattle, January 2005 Pediatric Trauma, Pediatric Education for the Prehospital Professional, Seattle, January 2005 What’s New: A Preview of the New Transport Guidelines; Transport of the Patient with Orthopedic Trauma and Pediatric Critical Care Transport Case Studies, Neonatal and Pediatric Transport Conference, Clearwater Beach, Fla., April 2005 Prehospital Management of the Critically Ill Child: Developing and Optimizing Emergency Medical Services and Injury Prevention: Comparisons, Successes and Opportunities and Radiology Assessment in the ER, 4th Curso Emergencis Pediatricas, Santiago, Chile, April 2005 Pediatric Orthopedic Injuries; Pediatric Head Trauma, 10th Annual Pediatric Emergency Care in Your Hospital, Dominican Hospital, Santa Cruz, Calif., April 2005 Pediatric Trauma: A Systematic Approach, WAMI 2005: Current Practices in Adult and Pediatric Trauma, Seattle, June 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 85 Emergency Medicine Curso de Trauma PediГЎtrico; Pediatric Head Trauma; Pediatric Orthopedic Trauma; Pediatric Advanced Life Support Instructor Course; Advanced Airway Assessment and Intervention; Vascular Access; Pediatric Case Scenarios (student and instructor) and Cervical Spine Immobilization and Stabilization, Congreso Mesoamericano y del Caribe de PediatrГa: El NiГ±o ed SituaciГіn de Crisis y de Desastres, Guatemala City, Guatemala, July 2005 Scientiп¬Ѓc Platform and Poster Session: Section on Transport Medicine (moderator) and Educational Requirements for Transport Practitioners, AAP National Conference and Exhibition, Washington, D.C., October 2005 Pediatric Critical Care Transport: Past, Present and Future, keynote address, Pediatric-Neonatal Critical Care Transport Conference, Boston, October 2005 An Approach to Pediatric Trauma, Pediatric Head Injury, Pediatric Orthopedic Injury, Pediatric Critical Care Transport Medicine, Pediatric Transport Cases and Pediatric Radiology, Children’s Hospital of Orange County Resident Retreat, Lake Arrowhead, Calif., November 2005 Pediatric Transport Cases and Pediatric Orthopedic Injury, 30th Alaska EMS Symposium, Anchorage, Alaska, November 2005 Paige Wright, MD, MS Pediatric Medical Emergencies, Pediatric Education of Prehospital Professionals, Seattle, January 2005 Pediatric Respiratory Arrest and Shock, Pediatric Advanced Life Support renewal and initial certiп¬Ѓcation, Seattle Children’s, April 2005 PUBLICATIONS Ake JA, Srdjan J, Ciol MA, Watkins SL, Murray KF, Christie DL, Klein EJ, Tarr PI. Relative nephroprotection during Escherichia coli 0157:H7 infections: association with intravenous volume expansion. Pediatrics. 2005;115(6):e673–e680. Brownstein D, Dieckmann R. Pediatric Education for Prehospital Professionals, Student Manual. Sudbury, 86 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON MA: American Academy of Pediatrics and Jones and Bartlett Publishers, 2005. Coleman B, Grant T, Mueller B. Hospitalization and infant outcomes among women exposed and unexposed to tocolysis. Journal of Perinatology. 2005;25(4):258–265. Diekema DS, Committee on Bioethics, American Academy of Pediatrics. Clinical report: responding to parental refusals for vaccination of children. Pediatrics. 2005;115(5):1428–1431. Horowitz R, Mazor S, Leikin, J. Pediatric clonidine patch ingestion. Am J Ther. May–June 2005;12(3):272–274. Kaplan R. Gastrointestinal bleeding. In: Signs and Symptoms in Pediatrics Urgent and Emergent Care. Davis MA, Gruskin KG, Chiang VW, Manzi S, eds. Philadelphia: Elsevier Mosby, 2005. Mazor S. Antidotes. In: Pediatric Toxicology, Care of the Poisoned Child. Erickson T, Aks S, Ahrens W, Ling L, Baum C, eds. McGraw Hill, 2005. Mazor S. Toxicology. In: Just the Facts in Pediatrics. Green TP, Tanz RR and Franklin W, eds. McGraw Hill, 2005. Stephens BD, Diekema DS, Klein EJ. Recreational injuries in Washington state national parks. Wilderness and Environmental Medicine. 2005;16(4):192–197. Woodward GA. Rocky Mountain spotted fever and Trichinosis (two chapters). In: The 5-Minute Pediatric Consult, 4th edition. Schwartz MW, ed. Philadelphia: Lippincott Williams and Wilkins, 2005. Wright PL, Woodward GA. Altitude illness and heat stroke and related illness (two chapters). In: The 5Minute Pediatric Consult, 4th edition. Schwartz MW, ed. Philadelphia: Lippincott Williams and Wilkins, 2005. Zerr DM, Blume HK, Berg AT, Del Beccaro MA, Gospe SM, Allpress AL, Christakis DA. Nonfebrile illness seizures: a unique seizure category? Epilepsia. 2005;46:952–955. Endocrinology and Diabetes The Division of Endocrinology (in the Department of Pediatrics) provides consultation and long-term management for children and adolescents with diabetes and endocrine disorders in the WAMI region (Washington, Alaska, Montana, Idaho). The division’s approach to patient care blends clinical practice, research and education. A multidisciplinary team of dedicated physicians, mid-level providers, certified diabetes nurse educators, dietitians and social workers offer familycentered care in both inpatient and outpatient settings. Endocrinologists work with primary care providers and other sub-specialists to manage endocrine disorders in children with complex health care needs. Collaborative research efforts are underway in pediatric diabetes and gonadal disorders, and with childhood cancer survivors. In 2005 the division launched American College of Graduate Medical Education (ACGME)–accredited, sub-specialty residency program, enhancing teaching efforts and recruitment potential for pediatric endocrine providers. TEACHING, RESEARCH AND CLINICAL EXPERTISE Catherine Pihoker, MD, is chief of the Division of Endocrinology and Diabetes and attending physician at Seattle Children’s Hospital and associate professor in the Department of Pediatrics at the University of Washington School of Medicine. Her clinical focus is inpatient and outpatient attending for endocrinology and diabetes. Her main research interests include investigating factors that predict the clinical course of diabetes, diabetes typology and improving outcomes of children with diabetes. Dr. Pihoker is also interested in the impact on children of being overweight and living sedentary lifestyles, and she is involved in proposals studying the quality of life and metabolic measures in the general population as well as in cancer survivors. Other research interests include endocrine dysfunction in childhood cancer survivors and hypothalamic-pituitary function in children with tumors in the pituitary FACULTY Catherine Pihoker, MD, Chief Helen L. Dichek, MD Daniel F. Gunther, MD, MA Gad B. Kletter, MD Gail E. Richards, MD Catherine Pihoker MD, Chief region. The studies Dr. Pihoker has been involved with include the SEARCH for Diabetes in Youth, TrialNet and the Type 1 Diabetes Genetics Consortium. Her teaching activities include serving as fellowship director, and didactic and direct teaching of resident physicians, medical students and support staff. Helen L. Dichek, MD, is attending physician at Seattle Children’s Hospital and the University of Washington Medical Center; she is associate professor in the Department of Pediatrics, Endocrinology, at the University of Washington School of Medicine. She is a board-certiп¬Ѓed endocrinologist, with expertise in pediatric lipid disorders. Dr. Dichek directs the only regional pediatric lipid clinic in the WAMI area (Washington, Alaska, Montana, Idaho), which meets at Seattle Children’s and at the University of Washington Medical Specialties Lipid/Nutrition Clinic. Dr. Dichek’s research interests include genetic modiп¬Ѓers of atherosclerosis and development of animal models of obesity and fatty liver. Daniel F. Gunther, MD, MA, is attending physician at Seattle Children’s Hospital and associate professor of pediatrics at the University of Washington School of Medicine. His primary clinical and research interests are Turner syndrome, disorders of growth and puberty and intersex disorders. In addition to seeing general endocrine and diabetes patients at Children’s Hospital, Dr. Gunther attends regional clinics in Federal Way and Yakima, Wash. He serves on the Scientiп¬Ѓc Advisory Board to the CARES foundation, a national education and support group for individuals with congenital SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 87 Endocrinology and Diabetes adrenal hyperplasia. He is involved in research studying long-term effects of growth hormone treatment in girls with Turner syndrome, and is principal investigator in a study following individuals with Turner syndrome who have been diagnosed prenatally. Gad B. Kletter, MD, is attending physician at Seattle Children’s Hospital and associate professor of pediatrics at the University of Washington School of Medicine. His research interests include pubertal disorders and gonadotropin biochemistry and physiology. He is a member of the hospital’s Grand Rounds Steering Committee and is responsible for the monthly endocrine teaching seminar, an event offering community providers, students and other clinicians an opportunity to expand their knowledge of endocrine disorders in children and adolescents. Gail E. Richards, MD, is attending physician at Seattle Children’s Hospital and professor of pediatrics at the University of Washington School of Medicine. In addition to providing inpatient attending services at the hospital’s main campus, Dr. Richards provides patient care in the hospital’s regional clinics in Bellevue and Everett, Wash. She serves as director for the LawsonWilkins Pediatric Endocrine Society Clinical Research Network. Her research interests include growth and its disorders, and she participates in a number of clinical trials of new treatments for children with short stature. RESEARCH FUNDING Catherine Pihoker, MD Characteristics of Diabetes in Youth of the Puget Sound, Centers for Disease Control and Prevention/DHHS, $494,620 JDRF Center for Translational Research, Benaroya Research Institute at Virginia Mason, Juvenile Diabetes Research Foundation, $123,820 Gail E. Richards, MD Genentech National Cooperative Growth Study PostMarketing Surveillance Program for Protropin (Somatren for Injection) and Nutropin (Somatropin-rDNA Origin) for Injection, Genentech, Inc., $125,000 Norditropin National Registry, Novo Nordisk Pharmaceuticals, Inc., $277,553 TEACHING AND PRESENTATIONS Daniel F. Gunther, MD, MA Prenatal Diagnosis—Que Sera, Sera?, section chair, GeNeSIS Symposium, Washington, D.C., May, 2005 Congenital Adrenal Hyperplasia, housestaff conference, Seattle Children’s, 2005 Principles of Puberty, housestaff conference, Seattle Children’s, 2005 Disorders of Sex Differentiation, housestaff conference, Seattle Children’s, 2005 New Gad B. Kletter, MD Phase III - Open Label Study to Evaluate Efп¬Ѓcacy and Safety of Histrelin Subdermal Implant in Children with Central Precocious Puberty, Valera Pharmaceuticals, $113,073 Catherine Pihoker, MD SEARCH for Diabetes in Youth 2: Washington Site, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention/DHHS, $650,000 Continuing Helen L. Dichek, MD The Role of Hepatic Lipase in Cholesterol Homeostasis, NHLBI/NIH, $304,000 88 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Gad B. Kletter, MD Disorders of Thyroid, housestaff conference, Seattle Children’s, 2005 Disorders of the Adrenal Cortex, housestaff conference, Seattle Children’s, 2005 Short Stature, housestaff conference, Seattle Children’s, 2005 Catherine Pihoker, MD Autoantibodies in Diabetes, International Group on Insulin Secretion, St. Jean Cap Ferrat, France, March 2005 Endocrinology and Diabetes PUBLICATIONS Dichek HL, Agrawal, N, El Andaloussi N, Qian K. Attenuated corticosterone response to chronic acth stimulation in hepatic lipase-deп¬Ѓcient mice: evidence for a role for hepatic lipase in adrenal physiology. Am Physiol: Endocrinol Metabol. DOI, 2005. Gilliam LK, Brooks-Worrell BM, Palmer JP, Greenbaum CJ, Pihoker C. Autoimmunity and clinical course in children with type 1, type 2, and type 1.5 diabetes. J Autoimmun. November 205;25(3): 244–250. Gilliam LK, Jensen RA, Yang P, Weigle DS, Greenbaum CJ, Pihoker C. Evaluation of leptin levels in subjects at risk for type 1 diabetes. J Autoimmun. December 27, 2005; e-publication. Mauras N, Pescovitz OH, Allada V, Messig M, Wajnrajch MP, Lippe B, Transition Study Group (Kletter G). Limited efп¬Ѓciency of growth hormone (GH) during transition of GH-deп¬Ѓcient patients from adolescent to adulthood: A phase III multicenter, double-blind, randomized two-year trial. J. Clin Endocrinol Metab. 2005;90(7):3946–3955. Pihoker C, Gilliam LK, Hampe CS, Lernmark A. Autoantibodies in diabetes. Diabetes. 2005;54 (Suppl 2):S52–S61. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 89 Gastroenterology, Hepatology and Nutrition The Division of Gastroenterology, Hepatology and Nutrition (in the Department of Pediatrics) provides expertise in consultative gastroenterology for a broad range of gastrointestinal, liver and nutritional diseases. Our division provides comprehensive care for a number of children with complex gastrointestinal illnesses. The division is particularly skilled in the care of patients with intestinal failure, inflammatory bowel disease and acute and chronic liver disease. Three recently established programs are small bowel transplant, intestinal care and the Inflammatory Bowel Disease Treatment Center. We also provide ongoing consultation and treatment for patients with chronic recurrent abdominal pain, gastroesophageal reflux and malabsorptive syndromes. Technological advances in pediatric gastroenterology have enabled us to apply diagnostic and therapeutic endeavors to the upper intestinal digestive tract and colon. The recent addition of capsule endoscopy has enhanced our ability to care for children with unusual small intestinal diseases. Esophageal motility and anal rectal manometry are available to study selected patients. We work in close consultation with our colleagues in general surgery, radiology and pathology in the diagnosis and therapy of patients with gastrointestinal disease. Our emphasis on a team approach from a diagnostic and therapeutic perspective has enhanced our quality of care and provided our patients the most advanced expertise available in the WAMI region (Washington, Alaska, Montana, Idaho). The division has a long history of contributions to basic science and clinical research. We continue to be leaders in clinical and basic research in gastroenterology. Some of the division’s research investigations include treatment of hepatitis B, hepatitis C and acute liver failure; use of mesalamine in pediatric inflammatory bowel disease; maternal microchimerism in inflammatory bowel disease; and a controlled trial of managing recurrent abdominal pain. The division also participates in the western regional pediatric inflammatory bowel disease registry. TEACHING, RESEARCH AND CLINICAL EXPERTISE Dennis L. Christie, MD, is chief of the Division of Gastroenterology, Hepatology and Nutrition at Seattle Children’s Hospital and professor of pediatrics at the University of Washington’s School of Medicine. He is board certiп¬Ѓed in pediatric gastroenterology. Dr. Christie was instrumental in establishing the specialty of pediatric gastroenterology in the Paciп¬Ѓc Northwest. He collaborated in the establishment of the safety, efп¬Ѓcacy and practicality of using flexible п¬Ѓber optic endoscopy in the diagnosis and therapy of children with gastrointestinal diseases. Two of his early publications demonstrated the association between gastroesophageal reflux and recurrent respiratory disease. His research interests relate to inflammation in the intestine. He is actively involved with the Inflammatory Bowel Disease Treatment Center and the Autism Treatment Network. He serves as vice chairman of clinical affairs for the Department of Pediatrics and is a member of the Children’s University Medical Group Advisory 90 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Board. He is past president of the pediatric committee for the American College of Gastroenterology, is an active member of the North American Society for Pediatric Gastroenterology and belongs to the American Gastroenterological Association. Simon Horslen, MBChB, is medical director for liver and intestine transplantation at Seattle Children’s Hospital and professor of pediatrics at the University of Washington School of Medicine. He is helping lead the expansion of Children’s transplant program. Dr. Horslen earned his medical degree from the University of Bristol, England. He is a founding fellow of the Royal College of Pediatric and Child Health, is a member of the Royal College of Physicians and is accredited in general pediatrics and pediatric gastroenterology. He was medical director of the pediatric transplant program at the University of Nebraska Medical Center. Clinical and research interests include metabolic liver disease, intestinal failure and liver and intestine transplantation. Dr. Horslen is a member of the Hepatology Gastroenterology, Hepatology and Nutrition Committee for the North American Society of Gastroenterology, Hepatology and Nutrition and of the Cellular Transplant Committee for the American Society of Transplantation. He serves as co-chair of the Education Committee and member of the Nominations Committee for the International Pediatric Transplant Society. He is chairman of the United Network of Organ Sharing (UNOS) Pediatric Liver Transplant Subcommittee and member of the UNOS Pediatric Committee and the UNOS Liver & Intestine Committee. Mary K. Len, MD, is attending physician at Seattle Children’s Hospitals and clinical associate professor at the University of Washington School of Medicine. She was trained in pediatric gastroenterology at University of California, Los Angeles School of Medicine and is board certiп¬Ѓed in pediatric gastroenterology. Dr. Len has been a member of the outreach pediatric gastroenterology division attending clinics at Olympia and Federal Way, Wash., and is a member of the North American Society for Pediatric Gastroenterology and Nutrition. Her research interests include celiac sprue and inflammatory bowel disease. Karen F. Murray, MD, is director of the hepatobiliary program at Seattle Children’s Hospital and program director of gastroenterology education; she is associate professor in the Department of Pediatrics at the University of Washington School of Medicine. She received her MD from Johns Hopkins School of Medicine and did a pediatrics residency and a chief resident year at Seattle Children’s. She completed a clinical and research fellowship in gastroenterology and nutrition in the combined program at Children’s Hospital Boston and Massachusetts General Hospital, Harvard Medical School. Dr. Murray has done research and work in Bangladesh and Tanzania. In addition to clinical care FACULTY Dennis L. Christie, MD, Chief Simon Horslen, MBChB Mary K. Len, MD Karen F. Murray, MD David Suskind, MD Ghassan Wahbeh, MD in gastroenterology and transplantation, she has an active clinical research program in hepatology. Her main focus is in the treatment and pathophysiology of hepatitis C viral infection, and her studies also include the treatment of hepatitis B viral infection and nonalcoholic fatty liver disease. Dr. Murray is president-elect of Seattle Children’s medical staff. She is a member of the Gastroenterology Sub-board of the American Board of Pediatrics, and is on the steering committees of three National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) clinical research networks related to her research. She mentors pediatrics residents and speaks at Seattle Children’s noon conferences. David Suskind, MD, is attending physician at Seattle Children’s Hospital and assistant professor of pediatrics at the University of Washington School of Medicine. An expert in intestinal diseases, Dr. Suskind has focused much of his energy in clinical care and research in inflammatory bowel disease. He is studying the effect of maternal cells in inflammatory bowel disease (maternal microchimerism) as well as the effect of maternal cells in biliary atresia. He is chair of the nutrition committee at Seattle Children’s. He believes in patient and family empowerment through medical education. Ghassan Wahbeh, MD, is attending physician at Seattle Children’s Hospital and assistant professor of pediatrics and gastroenterology at the University of Washington School of Medicine. His work focuses on pediatric inflammatory bowel disease. His clinical and research interests include early diagnostic tools in pediatric IBD and advanced therapies. He also has clinical interests in upper gastrointestinal inflammatory conditions in children and interventional endoscopy. AWARDS AND HONORS Dennis L. Christie, MD Listed in “Best Doctors 2005,” Seattle magazine Mary K. Len, MD Award for excellence as part of the Olympia clinic based on patient survey results Dennis L. Christie MD, Chief SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 91 Gastroenterology, Hepatology and Nutrition RESEARCH FUNDING New Karen F. Murray, MD A Phase 3 Double-Blind, Randomized, Placebo-Controlled Study of the Safety and Efп¬Ѓcacy of Adefovir Dipivoxil in Children and Adolescents with Chronic Hepatitis B, Gilead Sciences, Inc., $98,327 David L. Suskind, MD Maternal Microchimerism in Inflammatory Bowel Disease, Broad (Eli and Edythe L.) Foundation, $142,178 TEACHING AND PRESENTATIONS Dennis L. Christie, MD All That Vomits Is Not Reflux and New Perspectives in Celiac Disease, North Paciп¬Ѓc Pediatric Society, 171st Scientiп¬Ѓc Conference, Blaine, Wash., August 25–28, 2005 New Perspectives in Celiac Sprue, Kennewick General Hospital, Kennewick, Wash., October 21, 2005 Understanding Gastroesophageal Reflux Disease in the Pediatric Patient, Central Washington Hospital, Wenatchee, Wash., October 28, 2005 Reflux Disorder, Providence Everett Medical Center, Bellevue, Wash., November 11, 2005 Isolated Liver Transplantation in Short Gut Patients – Missed Opportunities?, 9th International Small Bowel Transplantation Symposium, Brussels, Belgium, July 2, 2005 Liver and Intestinal Transplantation Outreach, Boise, Idaho, July 26, 2005 Growth, Puberty and Cognitive Development and Post-Graduate Course: Fundamentals of Pediatric Transplantation (course organizer), Third Congress of the International Pediatric Transplant Association, Innsbruck, Austria, August 2005 Neonatal Liver Disease, 75th North Paciп¬Ѓc Pediatric Society meeting, Blaine, Wash., August 28, 2005 Neonatal Liver Disease, Spokane Pediatric Society, Sacred Heart Hospital, Spokane, Wash., October 11, 2005 Liver and Intestine Transplantation in Children, pediatric Grand Rounds, Sacred Heart Hospital, Spokane, Wash., October 12, 2005 Liver Disease in Adolescence (chair and course organizer), AASLD/NASPGHAN Pediatric Symposium, AALSD annual meeting, San Francisco, November 2005 Mary K. Len, MD Celiac Sprue, Pediatricians of Olympia and teleconferenced to Wenatchee, Wash. February 2005 Visiting professor, Port Angeles, Wash., June 2005 Simon P. Horslen, MBChB Intestinal Transplantation, gastroenterology Grand Rounds, University of Washington, January 21, 2005 Liver and Intestinal Transplant Outreach, Spokane, Wash., March 2, 2005 Liver and Intestinal Transplant Outreach, Mary Bridge Children’s Hospital, Tacoma, Wash., April 14, 2005 Liver and Intestinal Transplant Outreach, Anchorage, Alaska, May 26–27, 2005 Karen F. Murray, MD Pediatric Gastroenterology: Common Problems and Hepatitis C Infection, plenary speaker, 33rd Annual Advances in Family Practice and Primary Care, Seattle, 2005 Common GI Problems, guest faculty lecture, noon conference, University of Washington, April 12, 2005 Cholestasis, guest faculty lecture, noon conference, University of Washington, 2005 Neonatal Cholestasis, lecture to nutritionists in the region, ROSS, May 10, 2005 Visiting professor: Pocatello and Boise, Idaho, 2005 92 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Gastroenterology, Hepatology and Nutrition Ghassan T. Wahbeh, MD Visiting professor, Great Falls, Mont., April 2005 Update on Treatment for Pediatric Inflammatory Bowel Disease, Crohn’s & Colitis Foundation, Evergreen Hospital Medical Center, January 2005 Celiac Disease, community physician meeting, St. Francis Hospital, Federal Way, Wash., February 2005 Diagnosis of IBD in Children and Treatment of IBD in Children, Oregon Health Sciences & University of Washington Fellows IBD Retreat, Port Ludlow, Wash., October 2005 Dubinsky M, Mei L, Landers C, Katzir L, Farrior S, Wrobel I, Quiros A, Bahar R, Wahbeh G, Grill B, Silber G, Kelts D, Pietzak M, Dallazadeh S, Vasiliauskas E, Nelson C, Hershberg R, Huiying Y, Rotter J, Targan S. Antibodies to a novel flagellin (CBIR1) adds clinical utility to the diagnosis and differentiation of pediatric IBD. NASPGHAN meeting, Salt Lake City. October 2005. Gonzalez-Peralta RP, Kelly DA, Haber B, Molleston J, Murray KF, Jonas MM, Shelton M, Mieli-Vergani G, Lurie Y, Martin S, Lang T, Baczkowski A, Geffner M, Gupta S, Laughlin M, International Pediatric Hepatitis C Therapy Group. Interferon alfa-2b in combination with ribavirin for the treatment of chronic hepatitis C in children: efп¬Ѓcacy, safety, and pharmacokinetics. Hepatology. 2005;42(5):1010–1018. PUBLICATIONS Ake JA, Jelacic S, Ciol MA, Watkins SL, Murray KF, Christie DL, Tarr PI. The nephroprotective effect of intravenous volume expansion during Eschericia coli 0157:H7 infection. Pediatrics. 2005;15(6):e673–e680. Bousvaros A, Guandalini S, Baldassano R, Botelho C, Evans J, Ferry G, Goldin B, Hartigan L, Kugathasan S, Levy J, Murray KF, Oliva-Hemker M, Rosh J, Tolia V, Young R, Zholudev A, Vanderhoof J, Hibberd PL. A randomized, double-blind trial of Lactobacillus GG vs. placebo in addition to standard maintenance therapy for children with Crohn’s disease. Inflamm Bowel Dis. 2005;11(9):833–839. Bousvaros A, Murray KF, Leichtner A. Clinical manifestation and diagnosis of Crohn’s disease in children and adolescents. In Up to Date. Chapra, LaMont, Bonis, eds. Up To Date, Wellesley, 2005. Dubinsky M, Mei L, Landers C, Katzir L, Farrior S, Wrobel I, Quiros A, Bahar R, Wahbeh G, Grill B, Silber G, Pietzak M, Vasiliauskas E, Dallalzadeh S, Kelts D, Nelson C, Hershberg R, Yang H, Targan S, Rotter J. Familial expression of serological immune responses in pediatric IBD. NASPGHAN meeting, Salt Lake City. October 2005. Murray KF, Barton B, Gonzalez-Peralta R, Rodrigue J, Hoofnagle J, Shepherd J, Schwarz K, the PEDS-C Clinical Research Network. Development of the п¬Ѓrst large-scale multi-center, randomized controlled trial for children with chronic Hepatitis C virus infection (PEDS-C). J Pediatr Gastroenterol Nutr. 2005;41(4):524. Murray KF, Carithers RL. AASLD practice guidelines: evaluation of the patient for liver transplantation. Hepatology. 2005;41(6):1407–1432. Murray KF, Finn LS, Taylor SL, Seidel KD, Larson AM. A comparison of liver histology and alanine amino transferase levels in children and adults with chronic hepatitis C. J Pediatr Gastroenterol Nutr. 2005;41(5):634–638. Richardson PG, Soiffer RJ, Antin JH, Voss SD, Jin Z, Kurtzberg J, Martin PL, Hockenberry D, Murray KF, Vogelsang GB, Chen A, Krishnan A, Kernan MA, Avignan D, Spitzer TR, Iannone R, Giralt S, Warren D, Momtaz P, Revta C, Bradwin G, Iacobelli M, McDonald GB, Guinan EC. Deп¬Ѓbrotide (DF) for the treatment of veno-occlusive disease (VOD) and multi-system organ failure (MOF) post SCT: analysis of response and survival according to degree of MOF. Submitted to the 47th American Society of Hematology, 2005. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 93 Gastroenterology, Hepatology and Nutrition Squires RH, Shneider BL, Bucuvalas J, Alonso E, Sokol RJ, Narkewicz MR, Dhawan A, Rosenthal P, Rodriguez-Baez N, Murray KF, Horslen S, Martin MG, Lopez MJ, Soriano H, McGuire BM, Jonas MM, Yazigi N, Shepherd RW, Schwarz K, Lobritto S, Thomas DW, Lavine JE, Karpen S, Ng V, Kelly D, Simonds N, Hynan LS. Acute liver failure in children: the п¬Ѓrst 348 patients in The Pediatric Acute Liver Failure Study Group. J Peds. Accepted December 2005. Sudan D, Dibaise J, Torres C, Thompson J, Raynor S, Gilroy R, Horslen S, Grant W, Botha J, Langnas A. A multidisciplinary approach to the treatment of intestinal failure. J Gastrointest Surg. 2005;9(2):165–77. Suskind DL, Murray KF. Viral hepatitis. In: Current Pediatric Therapy, 18th Edition. Burg, Ingelп¬Ѓnger, Polin, Gershon, eds. London: Elsevier, 2005 (in press). Sweet SC, Wong HH, Webber SA, Horslen S, Guidinger MK, Fine RN, Magee JC. Pediatric transplantation in the United States, 1995В¬2004. Am J Transplant. Accepted December 15, 2005. Wahbeh G, Wyllie R, Seidel K, Steffen R. Symptoms of reflux are not always reflective of persistent gastroesophageal reflux: a pediatric study using simultaneous impedance-pH monitoring. NASPGHAN meeting, Salt Lake City. October 2005. Weinberg A, Horslen S, Kaufman SS, Jesser R, DeVoll-Zabrocki A, Fleckton BL, Kochanowicz S, Seipel KR, Levin MJ. Safety and immunogenicity of Varicella-Zoster virus vaccine in pediatric liver and intestine transplant recipients. Am J Transplant. Accepted November 14, 2005. Weinberg A, Horslen S, Kaufman SS, Jesser R, DeVoll-Zabrocki A, Fleckten BL, Kochanowicz S, Seipel KR, Levin MJ. Safety and immunogenicity of Varicella zoster virus (VZV) vaccine in pediatric liver transplant recipients. 30th International Herpesvirus Workshop (IHW). Turku, Finland. August 2005. 94 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON General Pediatrics The Division of General Pediatrics (in the Department of Pediatrics) encompasses academic general pediatrics and adolescent medicine. It is one of the largest divisions in the Department of Pediatrics; members of the division are involved with clinical care, teaching, advocacy, administration and research. Our mission statement establishes our commitment “to improving the health of children by teaching and modeling the practice of general pediatrics, performing clinical research, and promoting the role of the general pediatrician as a provider of primary care and advocate for children and their families.” Our vision is for the division to continue to be the best division of general pediatrics in the nation. Members of the division provide inpatient and outpatient clinical care at several locations in Seattle: Seattle Children’s Hospital, Harborview Medical Center, University of Washington Medical Center, the medical center’s primary care center and the Odessa Brown Children’s Clinic. Our faculty are heavily involved with running medical student programs for the University of Washington School of Medicine, the residency program for the Department of Pediatrics and fellowship training programs. The division has a large research portfolio, and our advocacy activities are intimately linked with our clinical, teaching and research activities. TEACHING, RESEARCH, AND CLINICAL EXPERTISE Frederick P. Rivara, MD, MPH, is chief of the Division of General Pediatrics at Seattle Children’s Hospital, George Adkins professor of pediatrics at the University of Washington School of Medicine, and adjunct professor of epidemiology at the School of Public Health. He is vice chair of the Department of Pediatrics in the School of Medicine. Dr. Rivara received his MD from the University of Pennsylvania and an MPH from the University of Washington. He completed residencies at the Children’s Hospital Medical Center in Boston and the University of Washington and was a Robert Wood Johnson Clinical Scholar at the University of Washington. Dr. Rivara was director of the Harborview FACULTY Frederick P. Rivara MD, MPH, Chief Frederick P. Rivara, MD, MPH, Chief Abraham B. Bergman, MD Julia M. Bledsoe, MD Christine Caldwell, MD, MS Dimitri A. Christakis, MD, MPH Benjamin S. Danielson, MD Julian K. Davies, MD Donna M. Denno, MD Beth E. Ebel, MD, MSc, MPH Injury and Research Center in Seattle for 13 years. He was founding president of the International Society for Child and Adolescent Injury Prevention, and serves as deputy editor of the journal Injury Prevention. He is also editor of Archives of Pediatrics and Adolescent Medicine. His research interests have included the efп¬Ѓcacy and promotion of bicycle helmets, prevention of pedestrian injuries, youth violence, the epidemiology of п¬Ѓrearm injuries, intimate partner violence, interventions for alcohol abuse in trauma patients and the effectiveness of trauma systems in the care of pediatric and adult trauma patients. Dr. Rivara was elected to the Institute of Medicine in 2005. Kenneth W. Feldman, MD Elinor A. Graham, MD, MPH Brian D. Johnston, MD, MPH Catherine J. Karr, MD, PhD Charlotte W. Lewis, MD, MPH Lenna L. Liu, MD, MPH Paula Lozano, MD, MPH Rita M. Mangione-Smith, MD, MPH Edgar K. Marcuse, MD, MPH Carolyn A. McCarty, PhD Heather A. McPhillips, MD, MPH Wendy Mouradian, MD, MS John M. Neff, MD James W. Stout, MD, MPH Naomi F. Sugar, MD James A. Taylor, MD Monica S. Vavilala, MD Jeffrey A. Wright, MD Kyle Yasuda, MD SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 95 General Pediatrics Abraham B. Bergman, MD, is professor of pediatrics and adjunct professor of health services at the University of Washington. Dr. Bergman was head of the Division of General Pediatrics and chief of pediatrics at Harborview Medical Center in Seattle. Dr. Bergman practices what he calls “political medicine.” He has been responsible for landmark legislation to improve the health of children and families in the US including the Flammable Fabrics Act to make children’s sleepwear flame retardant, the Sudden Infant Death Syndrome Act to provide NIH funding for research into SIDS and legislation to create the National Health Service Corps. Locally he has been responsible for legislation to fluoridate water in Washington state, improve the safety of bicyclists, pedestrians and motorcyclists and to create the Consumer Product Safety Commission. More recently Dr. Bergman has been a Soros Fellow for his work in foster care and is associate editor of Archives of Pediatrics and Adolescent Medicine. His current area of interest is improving health care of foster children. Julia M. Bledsoe, MD, is clinical associate professor of pediatrics at the University of Washington School of Medicine. She is director of the University of Washington Center for Adoption Medicine and a staff pediatrician at the university’s Fetal Alcohol Syndrome Clinic. Dr. Bledsoe graduated from the University of Washington School of Medicine. She has worked for the US Public Health Service on the Navajo reservation in northwestern New Mexico, and conducted a faculty practice at the University of Washington’s Roosevelt Primary Care Clinic. She developed a panel of families formed through adoption and became recognized as a national leader in understanding the unique needs of these children over time. Through the Center for Adoption Medicine she provides pre-adoption counseling to families internationally. She also sees newly adopted children in consultation and welcomes local adoptees into her primary care practice. Dr. Bledsoe’s clinical interests include health care for foreign and domestic adoptees, travel medicine, strategies for managing complex behavioral issues and the multidisciplinary approach to diagnosing and treating children with alcohol-related neurological disorders. Christine Caldwell, MD, MS, is attending physician at Seattle Children’s Hospital and a pediatrician at the University of Washington Pediatric Care Center. Dr. Caldwell received her MD from Baylor College 96 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON of Medicine in Houston. She completed pediatric residencies at Baylor Afп¬Ѓliated Hospitals and David Grant USAF Medical Center/University of California, Davis, with a fellowship in adolescent medicine at the University of Washington Medical Center. She worked as a community pediatrician in Seattle for 10 years. At the Pediatric Care Center, she encourages teens to increase responsibility for their own health. Dimitri A. Christakis, MD, MPH, is director of the Child Health Institute at Seattle Children’s Hospital and the University of Washington School of Medicine, and associate professor of pediatrics at the university. He is associate editor of Archives of Pediatrics and Adolescent Medicine. Dr. Christakis has published more than 100 peer-reviewed articles and book chapters, and his current research interest is the effect of media usage on young children’s cognitive, emotional, behavioral and social development. His most recent studies have found an association between television and video viewing before the age of three years and attentional and cognitive problems at age seven. He is piloting interventions designed to both reduce and modify television viewing in preschool children. His research focuses on helping parents optimize their child’s media usage to take advantage of its beneп¬Ѓts and minimize negative effects. He is the author of the forthcoming book, The Elephant in the Living Room: Make Television Work for Your Kids. Benjamin S. Danielson, MD, is attending physician at Seattle Children’s Hospital. He has been medical director of the Odessa Brown Children’s Clinic in Seattle since 1999, and he holds the Janet and Jim Sinegal Endowed Chair for the Odessa Brown Children’s Clinic. The clinic has been an active part of Seattle’s multiethnic Central District since 1970, largely serving children from disadvantaged backgrounds. The clinic offers dental, mental health and medical services and has special programs for children with sickle cell disease, asthma, school underachievement and obesity. Dr. Danielson completed his residency training at Seattle Children’s. He has worked in a pediatric sports medicine clinic at Harborview Medical Center, a school-based teen health center and a primary care clinic in West Seattle, and was an emergency department attending at Seattle Children’s. Dr Danielson splits his time between clinical care, administrative responsibilities, community advocacy and hospital responsibilities. He serves on several community General Pediatrics boards, is active in mentoring efforts and participates in a number of Seattle Children’s committees. Julian K. Davies, MD, is attending physician at Seattle Children’s Hospital, clinical assistant professor of pediatrics at the University of Washington and staff pediatrician at the university Fetal Alcohol Syndrome Clinic, the longest-standing FAS center in the US. He is co-director of the Center for Adoption Medicine, where he provides pre-adoption consultations, postplacement evaluations and ongoing general pediatric care for adopted children. He created and is the primary author for the Center for Adoption Medicine Web site, an online resource for medical and developmental issues in adoption and pediatrics. For the past eight years, he has been a volunteer with Maria’s Children, an arts rehabilitation center for Russian orphans, teaching children’s theater and clowning, and directing a summer arts camp for children living in Moscow orphanages. Donna M. Denno, MD, is attending physician at Seattle Children’s Hospital, acting assistant professor of pediatrics at the University of Washington School of Medicine, clinical assistant professor at the university School of Public Health and attending pediatrician at Harborview Medical Center. She earned her MD at the University of Michigan Medical School. Her clinical and research areas of interest include gastrointestinal infections in children and risk factors related to food safety. She has a strong interest in global medicine and lived and worked in Ghana for three years; her interests include the impact of intermittent presumptive treatment of malaria on anemia, the prevalence of pneumococcal disease in children and determinants of health. She is also interested in global medicine education and п¬Ѓeld opportunities for physicians in training, particularly residents at Seattle Children’s. Beth E. Ebel, MD, MSc, MPH, is assistant professor of pediatrics at the University of Washington School of Medicine and associate director of the Injury Prevention & Research Center at Harborview Medical Center. She received an MSc in development economics from Oxford University, an MD from Harvard Medical School and the MIT Health Sciences and Technology Program and an MPH from the University of Washington. Dr. Ebel’s research interests include injury prevention, community interventions and health behaviors with emphasis on high-risk populations. She is principal investigator in studies of the Seattle campaign to encourage booster seat use for young passengers and in a multisite community intervention to improve child passenger safety in Latino communities. She is also the principal investigator for several studies measuring the health care costs of unrestrained motor vehicle occupants. Kenneth W. Feldman, MD, divides his time between primary care pediatrics at the Odessa Brown Children’s Clinic in Seattle and child abuse consultation and supervision of inpatient and emergency room care at Seattle Children’s Hospital. Research interests have focused on childhood injuries, including tap water burn injuries. Elinor A. Graham, MD, MPH, directs the Children and Teen Clinic at Harborview Medical Center in Seattle. She earned her MPH at the Johns Hopkins School of Public Health. Dr. Graham’s work focuses on children and teens from low-income families; she has specialized in helping to build community support structures for these families. She helped set up the Mud Creek Health Project in Floyd County, Kentucky, to serve disadvantaged communities. She worked for the Seattle-King County Department of Public Health at their Children and Teen clinic for 10 years, emphasizing the expansion of pediatric services at health department clinics in the county, school health and training low-income and immigrant parents to be more effective advocates for their children’s education. She helped establish the Community House Calls program and EthnoMed Web sites to provide case management and community outreach services to immigrant communities. She has supported pediatric residents in conducting health projects at international sites and has joined them for work with a project in El Salvador. Brian D. Johnston, MD, MPH, is attending physician at Seattle Children’s Hospital and associate professor of pediatrics at the University of Washington School of Medicine. He is chief of pediatrics at Harborview Medical Center, the only level 1 trauma center in the WAMI region (Washington, Alaska, Montana, Idaho). He directs Harborview’s educational programs for pediatric residents and medical students and oversees hospital services and resources for pediatric patients. He earned his MD at the University of California, San Diego School of Medicine and his MPH at the University of Washington School of Public Health. His clinical SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 97 General Pediatrics interests include medical consultation for pediatric trauma patients, screening and treatment of traumatic stress in children and integration of mental health services into primary care. He conducts epidemiologic research in the impact of child injury on family systems and tests interventions to promote community-based injury prevention. His work includes school-based programs to promote physical activity while reducing the risk of child pedestrian injury. On a national level, Dr. Johnston has been involved in efforts to bring evidence-based injury prevention into the work of local child fatality review teams. Catherine J. Karr, MD, PhD, is a pediatrician at the University of Washington Pediatric Care Center; she has an adjunct appointment in the Department of Environmental and Occupational Health Sciences. She is director of the Northwest Pediatric Environmental Health Specialty Unit (PEHSU) at the University of Washington. Her education includes an MS in environmental health/toxicology; she earned her MD from the university School of Medicine and her PhD in epidemiology from the School of Public Health. She was recently selected to serve on the American Academy of Pediatrics Committee on Environmental Health. Her primary research interest is the adverse effects of environmental toxicants on child health. Her current research is in the area of infant health and ambient air pollution and pesticide risk communication. She is involved in primary care pediatrics and teaching and also sees specialty pediatric environmental medicine patients. Charlotte W. Lewis, MD, MPH, is attending physician at Seattle Children’s Hospital and assistant professor of pediatrics at the University of Washington School of Medicine. Her primary research interest is disparities in health and health care access, with a speciп¬Ѓc focus on oral health and access to dental care. Her research has involved documenting disparities in access to oral health services for low-income and special needs children as well as developing and evaluating strategies to improve pediatric oral health through expanded pediatrician and family physician involvement in these areas. 98 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Lenna L. Liu, MD, MPH, is clinician at Odessa Brown Children’s Clinic, assistant professor of pediatrics at the University of Washington School of Medicine and investigator at the Child Health Institute. She earned her MD from the University of Pennsylvania and her MPH from the University of Washington School of Public Health. She completed a pediatric residency at the University of Washington. Dr. Liu is co-investigator on the SEARCH for Diabetes in Youth study that examines rates of diabetes, particularly type 2 diabetes, in children and adolescents. She is active in Seattle Children’s Hospital Obesity Action Team, the university Center for Public Health Nutrition, and the Seattle-King County Public Health Department’s Steps to Health project. At the Odessa Brown Children’s Clinic she teaches medical students and residents and is developing an outreach program for improving nutritional services and physical activity opportunities in a community clinic setting. She is a consultant for the Community House Calls program at Harborview Medical Center, which does outreach and case management for refugee and immigrant communities. Dr. Liu is a member of the American Diabetes Association’s Asian and Paciп¬Ѓc Islander Advocacy Council. Paula Lozano, MD, MPH, is attending physician at Seattle Children’s Hospital, associate professor of pediatrics at the University of Washington School of Medicine and adjunct associate professor of health services at the university School of Public Health. Dr. Lozano is also associate investigator at the Center for Health Studies at Group Health Cooperative in Seattle, and she practices and teaches pediatrics at the Children and Teens Clinic at Harborview Medical Center. Dr. Lozano’s research has explored the characteristics of health care for children with chronic illnesses. She has conducted several randomized trials of primary care–based interventions rooted in the chronic care model. Special populations of interest include children with asthma, ADHD, depression and obesity and disadvantaged children. Dr. Lozano’s activities focus on developing and evaluating interventions to support health behavior change in primary care pediatric settings, using self-management support models derived from motivational interviewing. She has also published in the areas of quality of care, access to care, health literacy, cultural competence and electronic decision support and managed care. She also serves as pediatric co-director for the NRSA Primary Care Research Fellowship. General Pediatrics Rita M. Mangione-Smith, MD, MPH, is attending physician at Seattle Children’s Hospital and associate professor of pediatrics at the University of Washington. Her primary research interests are quality and appropriateness of care in pediatrics and the development of interventions to improve care provided to children. She is particularly interested in developing communication-based interventions to improve quality. Dr. Mangione-Smith has taken an active role on several quality-of-care projects at the University of California, Los Angeles and RAND. At RAND, she took a supervisory role on a project to develop a comprehensive pediatric quality-of-care assessment tool. She has collaborated with the measure development group at the National Committee for Quality Assurance (NCQA) to expand the number of evidence-based pediatric quality measures included in the HEDISВ®. Edgar K. Marcuse, MD, MPH, is associate medical director at Seattle Children’s Hospital, professor of pediatrics at the University of Washington School of Medicine and adjunct professor of epidemiology at the School of Public Health. Dr. Marcuse received his MD from Stanford University Medical School and his MPH from the University of Washington School of Public Health. He leads the hospital’s clinical quality improvement and patient safety activities. He has published extensively on immunization, general pediatrics and public health. Dr. Marcuse has served as a member and chair of the National Vaccine Advisory Committee, as a member of the American Academy of Pediatrics Committee on Infectious Disease, and associate editor of the Red Book. He is co-editor of AAP Grand Rounds, a monthly publication critiquing new studies relevant to pediatric practice. He is a member of the Advisory Committee on Immunization Practice. Carolyn A. McCarty, PhD, is research assistant professor in pediatrics at the University of Washington and holds an adjunct appointment in the Department of Psychology. Trained as a clinical psychologist, she is an active member of the American Psychological Association, the Society for Research in Child Development and the International Society for Research on Child and Adolescent Psychopathology. Her research has broadly focused on family, peer and cultural influences on children’s mental health. The goal of her research is to use knowledge of youth development to design, implement and test programs that will improve the lives and mental health of children. Through a partnership with the Seattle Public Schools, she is developing and testing a preventive intervention for young adolescents designed to reduce depression and improve their mental health, academic success and interpersonal functioning. Heather A. McPhillips, MD, MPH, is associate residency director for the University of Washington Pediatric Residency Training Program at Seattle Children’s Hospital. Dr. McPhillips earned her MD from the University of Chicago, Pritzker School of Medicine and her MPH at the University of Washington. She completed a pediatrics residency at the University of California, San Francisco and a fellowship at the University of Washington. She focuses her clinical and teaching efforts on the importance of understanding patients and their families in terms of their development, innate and learned behaviors and the social and medical context in which they live. Her research focus is on health care quality and patient safety as well as graduate medical education. She is a member of the Association of Pediatric Program Directors (APPD) and serves on the research task force for the APPD. She is also a member of the Ambulatory Pediatric Association and the American Academy of Pediatrics. Wendy Mouradian, MD, MS, is clinical professor of pediatrics at the University of Washington, with adjunct appointments in pediatric dentistry, dental public health sciences and health services (at the School of Public Health). She is director of regional initiatives for the university School of Dentistry and has served as director of the craniofacial program at Seattle Children’s Hospital. Dr Mouradian also heads the Oral-Systemic Theme Committee at the university School of Medicine, charged with integrating oral health into the curriculum of medical students. Dr. Mouradian earned her MD from Columbia University and her MS from the Massachusetts Institute of Technology. She completed a fellowship at the University of Washington. Dr Mouradian has received several national awards for her role organizing and chairing The Face of a Child: Surgeon General’s Conference on Children and Oral Health; she was recognized by the American Dental Education Association for her efforts to advance the importance of oral health to the overall health of children. She is associate director of the Center for Leadership Education in Pediatric Dentistry. Her research areas include quality of life for children with craniofacial conditions, ethics and educational policy related to children’s oral health. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 99 General Pediatrics John M. Neff, MD is director of the Center for Children with Special Needs at Seattle Children’s Hospital and professor of pediatrics at the University of Washington School of Medicine. He received his MD from Harvard Medical School. He was a member of the Epidemic Intelligence Service of the Public Health Service and trained in virology and infectious diseases at Children’s Hospital Boston. He was instrumental in determining the prevalence of complications associated with smallpox vaccination in the US. Dr. Neff served on the faculty and in the dean’s ofп¬Ѓce at Johns Hopkins Medical School. He directed the pediatric program at The Baltimore City Hospitals, where he developed a prepaid practice plan for the city’s foster children. He has worked on issues concerning children with special needs, including identiп¬Ѓcation, delivery of services and п¬Ѓnances. He has served as medical director and vice president of Seattle Children’s and associate dean at the University of Washington School of Medicine. He has broad interests in child health and advocacy with two special interests — smallpox and smallpox vaccination, and how to best serve children with special health care needs in our current environment. He has served on many state and national committees. James W. Stout, MD, MPH, is pediatrician at the Odessa Brown Children’s Clinic and associate professor of pediatrics and adjunct associate professor of health services at the University of Washington. He leads the clinic’s Asthma Clinic and provides direction for its quality improvement programs. Dr. Stout is co-founder of the National Initiative for Children’s Healthcare Quality, a nonproп¬Ѓt organization headquartered in Boston. He also leads QI Partners, a quality improvement group based at the Child Health Institute (CHI) in Seattle. Through these organizations, he works on a variety of local and national projects with the common aim of improving the quality of children’s health care. Naomi F. Sugar, MD, is attending pediatrician at Seattle Children’s Hospital and Harborview Medical Center and clinical associate professor at the University of Washington School of Medicine. She is medical director of the Harborview Center for Sexual Assault and Traumatic Stress and child abuse consultant at Harborview Medical Center and Seattle Children’s. She earned her MD at the Medical College of Wisconsin, completed an internship and a residency in pediatrics at Children’s Hospital of Pittsburgh, and completed a fellowship in behavioral pediatrics. She specializes in 100 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON the evaluation of children and adolescents when there is a concern for physical or sexual abuse, and in health care for children in foster care. Dr. Sugar provides training to medical, legal and social service professionals in the medical aspects of child abuse and adolescent and adult sexual assault. Her research interests are in evaluation of child abuse and foster care. James A. Taylor, MD, is attending physician at Seattle Children’s Hospital, medical director of the newborn nursery at the University of Washington Medical Center and director of the Pediatric Residency Continuity Clinic Program. He earned his MD from the University of North Carolina School of Medicine; he completed a pediatric residency at the University of Colorado and a fellowship in general pediatrics at the University of Washington School of Medicine. He is director of the Puget Sound Pediatric Research Network, a collaborative effort of practicing pediatricians in the community, the university Division of General Pediatrics and Seattle Children’s. Dr. Taylor’s research interests include maximizing the effectiveness of immunization delivery in primary care practices, eliminating racial disparities in immunization status, assessing the efп¬Ѓcacy of alternative therapies for children, developing and assessing methods to promote the judicious use of antibiotics in children and pediatric patient safety. Monica S. Vavilala, MD, is attending physician in the Emergency Department at Seattle Children’s Hospital, and she is associate professor in the departments of Pediatrics and Anesthesiology and adjunct associate professor in the Department of Neurological Surgery at the University of Washington School of Medicine. She practices anesthesiology at Harborview Medical Center. She is also involved in teaching anesthesiology and pediatric trainees. Dr. Vavilala’s research interests include hemodynamics and outcomes in pediatric brain injury, and mechanisms of cerebral edema in pediatric diabetic ketoacidosis. Jeffrey A. Wright, MD, is associate professor at the University of Washington School of Medicine and adjunct associate professor in the School of Dentistry. He is medical director of the university Pediatric Care Center and attending physician in the newborn nursery at the University of Washington Medical Center. Dr. Wright earned his MD at the University of Missouri–Kansas City and was resident and chief resident at Children’s Mercy Hospital in Kansas City. He has directed the General Pediatrics general pediatric service at Seattle Children’s Hospital, including the Medical Diagnostic/Referral Clinic, Encopresis Clinic, Infant/Toddler Growth Clinic and resident continuity clinic. Dr. Wright’s research interests include behavioral pediatrics, children with special health care needs and medical informatics. He is a computer and Web programmer working to use information technology for improving decision support, individualized care and coordination of care. Kyle Yasuda, MD, is clinical professor of pediatrics at the University of Washington School of Medicine and medical director of the Pediatric Clinic at Harborview Medical Center. He works in the new College Program, an integrated four-year curriculum to teach clinical skills and professionalism. He has a background in primary care practice, health policy, nonproп¬Ѓt organizations and advocacy for children and pediatricians. He is chair of the American Academy of Pediatrics (AAP) Committee on Practice and Ambulatory Medicine, immediate past chair of the Washington Council for the Prevention of Child Abuse and Neglect, former member of the Department of Social and Health Services State Advisory Committee and former member of the Governor’s Commission on Early Learning. He has held leadership positions for the AAP Washington Chapter, including nominee for the Primary Care Health Policy Fellowship. Dr. Yasuda formed and manages the 501C3 nonproп¬Ѓt foundation of the chapter that focuses on community-based collaborative research and education projects involving practicing pediatricians. He received the national 2005 Commissioner’s Award for his contributions to the п¬Ѓeld of child abuse and neglect. AWARDS AND HONORS Benjamin S. Danielson, MD UW School of Medicine Charlie Garcia Distinguished Service Award for Mentoring, January 2005 Home Care Association of Washington’s Physician of the Year, May 6, 2005 Distinguished Faculty Honoree, University of Washington, October 20, 2005 Janet and Jim Sinegal Endowed Chair for the Odessa Brown Children’s Clinic, awarded 2005 Beth E. Ebel, MD, MSc, MPH Special Emphasis Award for teaching and mentorship, Robert Wood Johnson Clinical Scholars Program, 2005 Elected to Society for Pediatric Research Elinor A. Graham, MD, MPH Helen Rodriguez-Trias Award for Social Justice, American Public Health Association, 2005 Catherine J. Karr, MD, PhD NIH Pediatric Research Loan Repayment Program Award Paula Lozano, MD, MPH Robert Wood Johnson Clinical Scholars Program Mentor Award Carolyn A. McCarty, PhD Travel Award, Family Research Consortium, 2005 Wendy Mouradian, MD, MS American Dental Education Association, Presidential Citation, 2005 Frederick P. Rivara, MD, MPH Elected to the Institute of Medicine (IOM) of the National Academies James W. Stout, MD, MPH University of Washington, Innovator Recognition Program, 2005 Monica S. Vavilala, MD EuroNeuro Poster Presentation Prize, 2005 University of Washington Department of Anesthesiology B. Raymond Fink Award for Research, 2005 Kyle Yasuda, MD Stanley Stamm Role Model in Medicine Award, 2004–2005 National 2005 Commissioner’s Award for Washington State SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 101 General Pediatrics New James W. Stout, MD, MPH Children’s Preventive Collaborative Year 1, King County Public Health, $80,644 Abraham B. Bergman, MD Child Abuse Consultation Network, Washington DSHS, $60,375 Children’s Preventive Collaborative Year 2, King County Public Health, $80,410 Dimitri A. Christakis, MD, MPH Parent-Initiated Prevention Program, AHRQ, $516,117 NICHQ YR 6, National Initiative for Children’s Healthcare Quality, $177,318 RESEARCH FUNDING Beth E. Ebel, MD, MSc, MPH Dissemination of Booster Seat Community Intervention to the Latino Community, Centers for Disease Control and Prevention, $223,090 Impact of a Primary Enforcement Seat Belt Law on Health Care Costs in Washington State, Washington Trafп¬Ѓc Safety Commission, $73,124 Increasing Booster Seat Use in At-Risk Communities: Tailored Communication and Behavioral Change, Robert Wood Johnson Foundation, $79,584 Improving Child Occupant Protection in Latino Families, Washington Trafп¬Ѓc Safety Commission, $75,648 Brian D. Johnston, MD, MPH Improving Injury Prevention Capacity in the Child Death Review Process, EMSC/MCHB/HRSA, $200,000 Lenna L. Liu, MD, MPH Diabetes in Youth, Centers for Disease Control and Prevention, $50,393 Paula Lozano, MD, MPH Asthma Management Support Curriculum for Pediatrics Residents, Group Health Community Foundation, $67,646 102 Continuing Abraham B. Bergman, MD Improving the Health Status of Foster Children in Washington State, Allen Foundation, $150,000 Brian D. Johnston, MD, MPH Family Stress, Resilience and Child Injury Risk, NICHD/’NIH, $113,803 Injury-Free Coalition for Kids of Seattle, Robert Wood Johnson Foundation, $50,734 Charlotte W. Lewis, MD, MPH Primary Care Provider and Preventive Oral Health, NIDCR/NIH, $125,959 Paula Lozano, MD, MPH Randomized Trial of a Computerized Asthma Management System, NHLBI/NIH, $461,602 Using Handheld Technology to Reduce Errors in ADHD Care, AHRQ, $293,136 Carolyn A. McCarty, PhD Prevention of Depression Among Pre-Adolescent Youth, NIMH/NIH, $115,855 Rita M. Mangione-Smith, MD, MPH Dr-Parent Communication and Antibiotic Over-Prescribing, AHRQ, $99,792 John M. Neff, MD Care Management for Children with Special Health Care: Addressing and Financing an Unmet Need, Maternal and Child Health Bureau/Health Resources and Services Administration/DHHS, $246,690 Frederick P. Rivara, MD, MPH Academic Administrative Units in Primary Care, HRSA, $217,093 Frederick P. Rivara, MD, MPH Program to Prevent Shaken Baby Syndrome and Infant Abuse, Doris Duke Charitable Foundation, $472,238 Effectiveness of Designated Driver Programs, Centers for Disease Control and Prevention, $350,000 Long-Term Effects of Domestic Violence, AHRQ/GHC, $81,309 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON General Pediatrics TEACHING AND PRESENTATIONS Benjamin S. Danielson, MD Disparities in Healthcare, Washington Health Foundation Conference, February 2, 2006 Overweight and Motivational Interviewing Techniques, Pediatric Weight Management Conference, Highline Hospital, March 21, 2005 Culture, Diversity and Obesity, National Association of Pediatric Nurse Practitioners National Conference, Phoenix, March 31, 2005 Culturally Competent Primary Care, NICHQ Community Health Collaborative, June 14, 2005 Overweight Among Youth, Paciп¬Ѓc Northwest Regional Conference, July 17, 2005 Culturally Competent Primary Care and Health Disparities, Washington State Diversity Summit, September 30, 2005 The Healthcare Needs of Minority Children, Washington Women’s Foundation Conference, November 2, 2005 Julian K. Davies, MD Lectures on international adoption and FAS at local adoption agencies, National Association of Adoption Attorneys conference and NACAC annual meeting Donna M. Denno, MD Development of a Disposable-Based, Multiplexed Labon-a-Chip Assay for Enteric Pathogens, Symposium on Vaccine Development, 40th annual panel meeting, United States – Japan Cooperative Medical Science Program, Boston, 2005 Casualties of War: Iraq and Health Care, Third Annual Western Regional International Health Conference, February 19, 2005 Beth E. Ebel, MD, MSc, MPH Invited speaker, Alberta Centre for Injury Control and Research Forum, Alberta, Canada, March 8, 2005 Booster Seat Use and The Health Care Costs of Unrestrained Drivers in Washington State, Three Flags Law Enforcement Conference. Olympia, Wash., April, 2005 Booster Seat Use in an Urban and Rural Latino Community: A Qualitative Study, 2005 National Injury Prevention and Control Conference, May 9, 2005 Prevention of Deaths from Violence in the United States: The Role of Interventions During Childhood and Adolescence, 2005 National Injury Prevention and Control Conference, May 10, 2005 Invited panelist, Lifesavers Conference on Injury Prevention in Latino Communities, Charleston, S.C., May 2005 Invited speaker, Risk Watch Community Coalition Workshop on Child Passenger Safety, Yakima, Wash., September 2005. Kenneth W. Feldman, MD Child Physical Abuse, Risk Factors and Early Recognition, King County Bar Assoc. CLE for Guardians ad Litem, Seattle, February 26, 2005 Problematic Nutrition and Growth, 26th Annual Duncan Seminar: Raising Special Needs Kids: Health, Growth, and Nutrition, Seattle, March 18, 2005 Child Abuse Recognition, Monthly Trauma Conference, Providence Hospital, Everett, Wash., April 13, 2005 Pediatric Condition Falsiп¬Ѓcation, Northwest Child Maltreatment Peer Review, Seattle, June 2005 Hypocalciuric Hypercalcemia Presenting as Neonatal Rib Fractures: A Newly Described Mutation in the Calcium-Sensing Receptor Gene, Ray E. Helfer Society, 5th annual meeting, New Paltz, N.Y., October 2005 Brian D. Johnston, MD, MPH Using Best-Evidence Topic Reports for Self-Learning and Practice Change in an Ambulatory Pediatric Rotation, poster presentation, Pediatric Academic Societies Annual Conference, Washington, D.C., May 14–May 17, 2005 Clinical Impact of Repeat Head CT in Pediatric Patients Admitted Following Blunt Head Trauma, American Society of Neuroradiology Conference, May 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 103 General Pediatrics Invited plenary session speaker, Injury Prevention Through Child Death Review, Injury and Violence in America: Meeting Challenges, Sharing Solutions, Denver, May 9–11, 2005 Catherine J. Karr, MD, PhD Childhood Lead Exposure via School Drinking Water: Assessing the Risk, platform presentation, Pediatric Academic Societies, May 2005 Impact of Prenatal and Early Infancy Environmental Exposures on Neonatal and Infant Health, American Thoracic Society, May 2005 Border Air Quality Study: Puget Sound Component, Border Air Quality Study Annual Conference, Victoria, BC, Canada, August 2005 Impact of Ambient Air Pollution on Infant Bronchiolitis in Puget Sound and the Georgia Air Basin, Paciп¬Ѓc Northwest Air & Waste Management International Association, November 2005 Organophosphate Pesticides and Children’s Health: A Primer for Health Care Providers, 15th Annual Western Migrant Stream Forum, Northwest Regional Primary Care Association, Portland, Ore., January 2006 Air Pollution and Children: Not Breathing Easy, Seattle Art Museum Series on Environment, March 16, 2005 Advances and Controversies in Pediatric Environmental Health, course director, University of Washington Center for Urban Horticulture, April 1, 2005 Lead and Other Toxicologically Relevant Metals, University of Washington, July 2005 Charlotte W. Lewis, MD, MPH Maternal and Child Oral Health Institute Meeting, keynote speaker, HRSA-MCHB, Denver, November 2–3, 2005 Lenna L. Liu, MD, MPH Childhood Obesity and Primary Care, University of New Mexico Department of Pediatrics Grand Rounds, April 2005 104 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Childhood Obesity and Primary Care, Mary Bridge Children’s Hospital Grand Rounds, June 2005 Primary Care Management of Overweight Children, Advanced Practice in Primary & Acute Care, Paciп¬Ѓc Northwest 28th Annual National Conference, October 2005 Paula Lozano, MD, MPH Missed Opportunities to Prescribe Controllers for Children with Persistent Asthma; Randomized Trial of Tailored Guideline-Based Electronic Decision Support: Can Computers Help Pediatricians Prescribe Controllers for Persistent Asthma?; Using a Tablet Computer to Gather Health Information; Exposure and Interest in Information to Reduce Asthma Triggers in Children; A Survey of Provider Satisfaction with an Electronic Prescription Writer in Three Ambulatory Pediatric Settings; and Risk Factors for Missing Influenza Vaccination Among Medicaid-Insured Children with Asthma, Pediatric Academic Societies annual meeting, Washington, D.C., May 2005 Rita M. Mangione-Smith, MD, MPH Assessing the Quality of Developmental Screening for Young Children: How Often Is Indicated Care Received? and Understanding Off-Label Prescribing to Children: How Often, Which Drugs, and Who Gets Them?, platform presentations, Pediatric Academic Societies annual meeting, Washington, D.C., May 16, 2005 Ruling Out the Need for Antibiotics: Are We Sending the Right Message?, Children’s Memorial Medical Center, Northwestern University, Grand Rounds, Chicago, December 2, 2005 Edgar K. Marcuse, MD, MPH Exploring Increased Public Participation in Making Public Health Policy Decisions – The Case of Pandemic Influenza and Our Pending Decision About Who First to Vaccinate, American Epidemiology Society annual meeting, March 2005 Vaccine Safety Issues and Immunization Hesitancy, American Academy of Pediatrics National Conference & Exhibition, Washington, D.C., October 2005 General Pediatrics Heather A. McPhillips, MD, MPH How Lean Processing Methods Took Resident and Attending Physicians Out of Their Team Rooms and Onto the Wards for Multidisciplinary Family-Centered Rounds, poster presentation, National Initiative for Children’s Healthcare Quality (NICHQ), 4th Annual Forum for Improving Children’s Health Care, San Diego, March 1, 2005 Whose Responsibility Is Children’s Oral Health?, keynote address, Royal Melbourne Children’s Hospital, Melbourne, Australia, Nov 2, 2005 When Cultures Collide: Strategies for Implementing Rapid Change Within an Academic Teaching Program, poster presentation, Association of Pediatric Program Directors annual meeting, Washington, D.C., March 13, 2005 Frederick P. Rivara, MD, MPH Second Annual Rud Polhill Lecture, Department of Pediatrics, University of Alabama, Birmingham, Ala., April 13, 2005 Do Multidisciplinary Walk Rounds Result in Earlier Discharges in an Academic Teaching Hospital?, poster presentation, Pediatric Academic Societies meeting, Washington, D.C., March 15, 2005 Communication, Teaching and Learning Styles, workshop co-leader, University of Washington School of Medicine faculty development workshop, March 29, 2005 Medication Safety in Ambulatory Pediatrics, Agency for Healthcare Quality and Research (AHRQ) Annual Patient Safety Meeting, Washington, D.C., June 6, 2005 Think Inside the Box! Incorporating Patient Safety into the Curriculum and Culture of Residency Training, Patient Safety Conference, Seattle Children’s, October 5, 2005 The Effect of a Standardized Rounding Practice on Patient Satisfaction, poster presentation, National Association of Children’s Hospitals and Related Institutions annual meeting, Indian Wells, Calif., October 12, 2005 Behavior: Birth to Toddler, pediatric residency noon conference series, University of Washington, 2005 Wendy Mouradian, MD, MS Oral Health for Montana’s Children and Families: What We Can Do Together, keynote address, Treasuring Montana’s Maternal and Child Health, Montana State – Spring Public Health Conference, Bozeman, Mont., May 2005 The Importance of Oral Health in Children: Ethical and Social Issues, keynote address, International Association of Pediatric Dentistry, Sydney, Australia, Nov 3, 2005 Methodologic Considerations for Injury Research, Ambulatory Pediatric Association Injury Control Special Interest Group, Pediatric Academic Societies annual meeting, Washington, D.C., May 16, 2005 James W. Stout, MD, MPH Innovations in Asthma Care, Paciп¬Ѓc West Cluster Transformation Summit, Portland, Ore., March 2005 Asthma Among First Nation and AI/AN Children: Translating Evidence Into Practice, Mini-Plenary and Workshop, International Meeting in Inuit and Native American Child Health: Innovations in Clinical Care and Research and 17th Annual IHS Research Conference, Seattle, Wash., April 2005 Naomi F. Sugar, MD HPV/HSV/HIV Viral Alphabet Soup and Abuse vs. Accident: Analysis of Anogenital Injuries, CAREs Northwest Child Abuse Medical Conference, 2005 Developmental Anatomy and Accidental Impalement Injuries in Children, San Diego Conference on Child Maltreatment, San Diego, 2005 James A. Taylor, MD Pediatric Practice-Based Research Networks: Potential and Pitfalls, Israeli Pediatric Research in Ofп¬Ѓce Settings Network Meeting, Tel Aviv, Israel, April 11, 2005 Building Research Capacity in Primary Care Through the Use of Practice-Based Research, The Israel National Institute of Health Policy and Health Services Research, The National Research Agenda for Primary Care Workshop, Dead Sea, Israel, April 14, 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 105 General Pediatrics Monica S. Vavilala, MD Blood Pressure Management in Severe Pediatric Traumatic Brain Injury, Children’s Hospital of Philadelphia, 2005 Blood Pressure Management in Severe Pediatric Traumatic Brain Injury, SAFAR Institute, Pittsburgh, 2005 Visiting professorship, Department of Anesthesiology, University of Texas, Houston, April 18, 2005 Visiting professorship, Safar Center, University of Pittsburgh, June 2005 Visiting professorship, Department of Anesthesiology, Mahidol University, Bangkok, Thailand, July 2005 Visiting professorship, departments of Anesthesiology and Pediatrics, Children’s Hospital of Philadelphia, August 2005 Kyle Yasuda, MD A Model for Peer-Based Training of Immunization Practitioners, abstract, National Immunization Conference, March 2005 Pediatricians — Partners in Early Childhood, Early Childhood and Health Partnerships Symposium, March 2005 Chan KS, Mangione-Smith R, Rosen M, Burwinkle TM, Varni JW. The PedsQLTM: reliability and validity of the short-form generic core scales and asthma module in children with asthma. Medical Care. 2005;43(3):256–265. Christakis DA, Cowan CA, Garrison MM, Molteni R, Marcuse E, Zerr DM. Variation in inpatient diagnostic testing and management of bronchiolitis. Pediatrics. Apr 2005;115(4):878–884. Christakis DA, Wright JA, Taylor JA, Zimmerman FJ. Association between parental satisfaction and antibiotic prescription for children with cough and cold symptoms. Pediatr Infect Dis J. Sep 2005;24(9):774–777. Coates BM, Vavilala MS, Mack C, Muangman S, Suz P, Sharar SR, Bulger E, Lam AM. The influence of deп¬Ѓnition and location of hypotension on outcome following severe pediatric traumatic brain injury. Crit Care Med. 2005;33:2645–2650. Cohen AL, Rivara F, Marcuse EK, McPhillips H, Davis R. Are language barriers associated with serious medical events in hospitalized pediatric patients? Pediatrics. 2005;116:575–579. Cohen AL, Rivara FP, Davis R, Christakis DA. Compliance with guidelines for the medical care of п¬Ѓrst urinary tract infections in infants: a population-based study. Pediatrics. Jun 2005;115(6):1474–1478. PUBLICATIONS Bergman AB. Advocacy is not a specialty (commentary). Arch Pediatr Adolesc Med. Sept 2005;159(9):892. Bowman SM, Zimmerman FJ, Christakis DA, Sharar SR, Martin DP. Hospital characteristics associated with the management of pediatric splenic injuries. JAMA. Nov 23, 2005;294(20):2611–2617. Carroll AE, Zimmerman FJ, Rivara FP, Ebel BE, Christakis DA. Perceptions about computers and the Internet in a pediatric clinic population. Ambul Pediatr. March–April 2005;5(2):122–126. Chan KS, Keeler E, Schonlau M, Rosen M, MangioneSmith R. How does ethnicity and home language affect management practices and outcomes in children with asthma? Arch Pediatr Adolesc Med. 2005;159:283–289. 106 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Cummings P, Rivara FP, Thompson RS, Reid RJ. Ability of parents to recall the injuries of their young children. Inj. Prev. 2005;11:43–47. Davies JK, Bledsoe JM. Prenatal alcohol and drug exposures in adoption. Pediatr Clin North Am. Oct 2005;52(5):1369–1393. Denno DM, Stapp JR, Boster DR, Qin X, Clausen CR, Del Beccaro KH, Swerdlow DL, Braden CR, Tarr PI. Etiology of diarrhea in pediatric outpatient settings. Pediatr Infect Dis J. 2005;24(2):142–148. Edwards T, Patrick DM, Topolski T, Aspinall C, Mouradian W, Speltz M. Approaches to craniofacial-specific quality of life assessment in adolescents. Cleft Palate Craniofac J. 2005;42(1):12–24. General Pediatrics Feudtner C, Villareale N, Morray B, Sharp V, Hays R, Neff J. Technology-dependency among patients discharged from a children’s hospital: a retrospective cohort study. BioMed Central Pediatrics. 2005;5:8. Finkelstein JA, Lozano P, Fuhlbrigge AL, Carey VJ, Inui TS, Soumerai SB, Sullivan SD, Wagner EH, Weiss ST, Weiss KB. Practice-level effects of interventions to improve asthma care in primary care settings: the pediatric asthma care patient outcomes research team. Health Services Research. Dec 2005;40(6 Pt 1): 1737–1757. Fishman PA, Ebel BE, Garrison MM, Christakis DA, Wiehe SE, Rivara FP. Cigarette tax increase and media campaign cost of reducing smoking-related deaths. Am J Prev Med. Jul 2005;29(1):19–26. Fuhlbrigge AL, Carey VJ, Finkelstein JA, Lozano P, Inui TS, Weiss ST, Weiss KB. Validity of the HEDIS criteria to identify children with persistent asthma and sustained high utilization. Am Manag Care. May 2005;11(5):325–330. Galbraith A, Koepsell TD, Grossman D, Christakis DA. Medicaid acceptance and availability of timely follow-up for newborns with Medicaid. Pediatrics. Nov 2005;116(5):1148–1154. Garrison MM, Christakis DA. A teacher in the living room: electronic media and babies, toddlers, and preschoolers. Kaiser Family Foundation. Dec 2005. Garrison MM, Jeffries H, Christakis DA. Risk of death for children with Down syndrome and sepsis. J Pediatr. Dec 2005;147(6):748–752. Gentilello LM, Ebel BE, Wickizer TM, Salkever DS, Rivara FP. Alcohol interventions for trauma patients treated in emergency departments and hospitals: a cost beneп¬Ѓt analysis. Ann Surg. Apr 2005;241(4):541–550. Glew G, Fan J, Katon W, Rivara FP, Kernic M. Bullying, psychosocial adjustment, and academic performance in elementary school. Arch Pediatr Adol Med. 2005;159:1026–1031. Graham EA. Economic, racial and cultural influences on the growth and maturation of children. Pediatrics in Review. Aug 2005;26:284–288. Gruchalla RS, Pongracic J, Plaut M, Evans R, Visness C, Walter M, Crain E, Kattan M, Morgan W, Steinbach S, Stout JW, Malindzak G, Smartt E, Mitchell H. Inner City asthma study: relationships among sensitivity, allergen exposure, and asthma morbidity. Allergy Clin Immunol. 2005;115(3):478–485. Harsha WJ, Perkins JA, Lewis CW, Manning SC. Head and neck endocrine surgery in children: 1997 and 2000. Arch Otolaryngol Head Neck Surg. Jul 2005;131(7):564–570. Harsha WJ, Perkins JA, Lewis CW, Manning SC. Pediatric admissions and procedures for lymphatic malformations in the United States: 1997 and 2000. Lymphat Res Biol. 2005;3(2):58–65. Johnston BD, Huebner CE, Anderson ML, Tyll LT, Thompson RS. Healthy steps for young children in an integrated delivery system: child and parent outcomes at 30 months. Accepted for publication by Arch Pediatr Adol Med. December 2005. Karr CJ, Rivara FP, Cummings P. Severe injury among Hispanic and non-Hispanic white children in Washington State. Public Health Reports. 2005;120:19–24. Kattan M, Stearns SC, Crain EF, Stout JW, Gergen PJ, Evans R III, Visness CM, Gruchalla RS, Morgan WJ, O’Connor GT, Mastin JP, Mitchell HE. Cost-effectiveness of a home-based environmental intervention for inner-city children with asthma. J Allergy Clinic Immunol. 2005;166(5):1058–1063. Lapidus J, Smith NH, Ebel BE, Romero FC. Restraint use among Northwest American Indian children traveling in motor vehicles. Am J Public Health. Nov 2005;95(11):1982–1988. Lewis CW, Robertson A, Phelps S. Unmet dental care needs among children with special health care needs: implications for the medical home. Pediatrics. Sep 2005;116(3):e426–e431. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 107 General Pediatrics Lewis CW, Ose M, Aspinall C, Omnell L. Community orthodontists and craniofacial care: results of a Washington state survey. Cleft Palate Craniofac. Sep 2005;42(5):521–525. Liu LL, The SEARCH for Diabetes in Youth Study Group. Incidence of diabetes in United States children and adolescents. Diabetes. 2005;54 (suppl. 1):A31. McPhillips H, Stille C, Smith D, Pearson J, Stull J, Hecht J, Miller M, Davis R. Methodological challenges in describing medication dosing errors in children. In: Advances in Patient Safety: From Research to Implementation, vol. 2: Concepts and Methodology. Henriksen K, Battles J, Marks E, Lewin DI, eds. Rockville, MD: Agency for Healthcare Research and Quality; February 2005, 213–223. Liu LL, The SEARCH for Diabetes in Youth Study Group. Estimates of the prevalence of diabetes in United States children and youth by age and race/ethnicity. Diabetes. 2005;54 (suppl. 1):A247. McPhillips H, Stille C, Smith D, Pearson J, Stull J, Hecht J, Debellis K, Miller M, Kaushal R, Andrade S, Gurwitz J, Davis R. Potential medication dosing errors in outpatient pediatrics. J Pediatr. Dec 2005;761–767. Liu LL, Lawrence JM, Liese A, Pettitt D, Pihoker C, Dabelea D, Hardy L, Kilgo P, Romanowski A, Waitzfelder B, Kahn HS. The SEARCH for Diabetes in Youth Study Group. Prevalence of overweight among U.S. diabetic youth. Diabetes. 2005;54 (suppl. 1):A450. Miller P, Vavilala MS. Rozet I, Lee L, Muangman S, Mack C, Wang M, Hollingworth C. Risk factors for intraoperative hypotension during emergency decompressive pediatric craniotomy. J Neurosurg Anesthesiol. 2005;22. Mangione-Smith R, Schonlau M, Chan KS, Keesey J, Rosen M, Louis TA, Keeler E. Measuring the effectiveness of a collaborative method for quality improvement in pediatric asthma care: does implementing the chronic care model improve processes and outcomes of care? Ambul Pediatr. 2005;5(2):75–82. Mouradian W, Reeves A, Evans R, Kim S, Schaad D, Marshall S, Slayton R. Oral health curriculum for medical students at the University of Washington. Acad Med. 2005;80:434–442. Mangione-Smith R, Elliott MN, Wong L, McDonald L, Roski J. Measuring the quality of care for group A streptococcal pharyngitis in п¬Ѓve U.S. health plans. Arch Pediatr Adolesc Med. 2005;159:491–497. Mangione-Smith R, Wong L, Elliott MN, McDonald L, Roski J. Measuring the quality of antibiotic prescribing for upper respiratory infections and bronchitis in п¬Ѓve U.S. health plans. Arch Pediatr Adolesc Med. 2005;159:751–757. McCarty CA, Zimmerman FJ, Digiuseppe DL, Christakis DA. Parental emotional support and subsequent internalizing and externalizing problems among children. J Dev Behav Pediatr. Aug 2005;26(4):267–275. McCarty CA, McMahon RJ. Conduct Problems Prevention Research Group. Domains of risk in the developmental continuity of п¬Ѓresetting. Behav Ther. 2005;36(2):185–195. 108 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Muangman S, Rozet I, Vavilala MS, Lee LA, Kincaid MS, Souter MJ, Lam AM. Iso-osmolar solutions of mannitol vs. hypertonic saline for intraoperative brain relaxation. J Neurosurg Anesthesiol. 2005;243. Muangman S, Vavilala MS, Suz P, Kincaid MS, Lam AM. Return of cerebral autoregulation during the п¬Ѓrst week following severe pediatric traumatic brain injury. J Neurosurg Anesthesiol. 2005;220. Neff JM. Children with chronic conditions: Financial issues and other resources. In: Comprehensive Pediatrics. Osborn, DeWitt, First, Zenel, eds. Philadelphia: Elsevier/Mosby Publishing Co., 2005:881–884. Perkins J, Lewis CW, Gruss J, Eblen L, Sie K. Furlow palatoplasty for management of velopharyngeal insufп¬Ѓciency: a prospective study of 148 consecutive patients. Plast Reconstr Surg. Jul 2005;116(1):72–80. Poland GA, Grabenstein JD, Neff JM. The U.S. smallpox vaccination program: a review of a large modern era smallpox vaccination implementation program. Vaccine. 2005;23(17–18):2078–2081. General Pediatrics Rivara FP, Alexander B. Occupational injuries. In: Textbook of Clinical Occupational and Environmental Medicine. Rosenstock L, Cullen MR, eds. Philadelphia: Elsevier Saunders Company, 2005:825–833. Shah M, Feldman KW, Vavilala MS, Hallam DK. Motor vehicle crash brain injury in infants and toddlers: a suitable model for inflicted head injury? Child Abuse and Neglect. 2005;29:953–967. Rivara FP, Mock C. The 1,000,000 lives campaign. Inj Prev. Dec 2005;11(6):321–323. Sidman EA, Grossman DC, Koepsell TD, D’Ambrosio L, Britt J, Simpson EV, Rivara FP, Bergman AB. Evaluation of a community-based handgun safe-storage campaign. Pediatrics. June 2005;115(6);e654–e661. Rivara FP, Stapleton FB. Closing the quality chasm in health care: the role of critical reading. Arch Pediatr Adolesc Med. Apr 2005;159(4):394–395. Robertson AS, Rivara FP, Ebel BE, Lymp JF, Christakis DA. Validation of parent self reported home safety practices. Inj Prev. Aug 2005;11(4):209–212. Rodriguez B, Mayer-Davis E, Bell R, Palla S, Pihoker C, Liu LL, Kershnar A, Dolan L, Pettitt D, Klingensmith G, Imperatore G, Liese A, Waitzfelder B, Fujimoto W. The SEARCH for Diabetes in Youth Study: Prevalence of the metabolic syndrome among youth with diabetes. Diabetes. 2005;54 (suppl. 1):A64–A65. Smith R, Lewis CW. Availability of dental appointments for young and Medicaid-insured children in King County Washington: implications for access. Pediatric Dentistry. May–Jun 2005;27(3):207–211. Sugar NF, Feldman KW. Oral surgical aspects of child abuse and neglect. In: Management of the Pediatric Maxillofacial Patient. Egbert MA, Padwa BL, eds. Oral and Maxillofacial Surgery Clinics of North America. Philadelphia: Elsevier Saunders, 2005;17:435–446. Sox CM, Christakis DA. Pediatricians’ screening urinalysis practices. J Pediatr. Sep 2005;147(3):362–365. Rosengart M, Cummings P, Nathens A, Heagerty P, Maier R, Rivara FP. An evaluation of state п¬Ѓrearm regulations and homicide and suicide death rates. Inj Prev. Apr 2005;11(2):77–83. Sugar NF. Review of: Forensic gynaecology: towards better care of female victims of sexual assault. J Forensic Sci. 2005;50(3). Roudsari B, Ebel BE, Corso P, Molinari N, Koepsell T. The acute medical care costs of fall-related injuries among U.S. older adults. Injury. Nov 2005; 36(11):1316–1322. Sugar NF, Feldman KW. Oral surgical aspects of child abuse and neglect. In: Oral and Maxillofacial Surgery Clinics of North America. Egbert MA, Padwa BL, eds. Philadelphia: Elsevier Saunders, 2005;17:435–446. Sabin JA, Zatzick D, Rivara FP. A role for school health personnel in supporting children and families following childhood injury. J School Health. 2005;75:141–144. Sullivan SD, Lee TA, Blough DK, Finkelstein JA, Lozano P, Inui TC, Fuhlbrigge AL, Carey VJ, Wagner E, Weiss KB for the PAC PORT Team. A multi-site randomized trial of the effects of physician education and organizational change in chronic asthma care: cost-effectiveness analysis of the Pediatric Asthma Care Patient Outcomes Research Team II (PAC-PORT II). Arch Pediatr Adolesc Med. May 2005;159(5):428–434. Sander JB, McCarty CA. Youth depression in the family context: familial risk factors and models of treatment. Clin Child Fam Psychol Rev. 2005;8(3):203–219. Schonlau M, Mangione-Smith R, Rosen M, Chan KS, Louis TA, Keeler E. An evaluation of a quality improvement collaborative method in asthma care: does it improve processes and outcomes of care? Ann Fam Med. 2005;3:200–208. Thompson DA, Christakis DA. The association between television viewing and irregular sleep schedules among children less than 3 years of age. Pediatrics. Oct 2005;116(4):851–856. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 109 General Pediatrics Vavilala MS, Kincaid MS, Muangman SL, Suz P, Rozet I, Lam AM. Gender differences in cerebral blood flow velocity and autoregulation between anterior and posterior circulations in healthy children. Pediatr Res. 2005;58:574–578. Vavilala MS, Lam AM. Dentiп¬Ѓcation of pressure passive cerebral perfusion and its mediators after infant cardiac surgery. Pediatr Res. 2005;57(1):35. Vavilala MS, Lam AM. Cerebral pressure autoregulation and vasoreactivity in the newborn rat. Pediatr Res. 2005;57:294–298. Vavilala MS, Muangman P, Suz P, Kincaid MS, Lam AM. Relationship between cerebral autoregulation and outcome in children with severe traumatic brain injury. J Neurosurg Anesthesiol. 2005;220. Zatzick D, Russo J, Grossman DC, Jurkovich G, Sabin J, Berliner L, Rivara FP. Post-traumatic stress and depressive symptoms, alcohol use, and recurrent traumatic life events in a representative sample of hospitalized injured adolescents and their parents. J Pediatr Psychol. Aug 10, 2005. Zatzick DF, Russo J, Pitman RK, Rivara FP, Jurkovich G, Roy-Byrne P. Reevaluating the association between emergency department heart rate and the development of post-traumatic stress disorder: a public health approach. Biol Psychiatry. Jan 1, 2005;57(1):91–95. Vavilala MS, Souter MJ, Lam AM. Hyperemia and impaired cerebral autoregulation in a surgical patient with diabetic ketoacidosis. Can J Anesth. 2005;52:323–326. Zatzick D, Russo J, Rivara FP, Roy-Byrne P, Jurkovich G, Katon W. The detection and treatment of post-traumatic distress and substance intoxication in the acute care inpatient setting. Gen Hosp Psychiatry. Jan–Feb 2005;27(1):57–62. Vavilala MS, Todd MM, Hindman MD, Clarke WR, Torner JC. For the intraoperative hypothermia for aneurysm surgery trial: mild hypothermia during surgery for intracranial aneurysm. NEJM. 2005;352:135–145. Zerr DM, Blume HK, Berg AT, Del Beccaro MA, Gospe SM Jr., Allpress AL, Christakis DA. Nonfebrile illness seizures: a unique seizure category? Epilepsia. Jun 2005;46(6):952–955. Weiss KB, Lozano P, Finkelstein J, Carey V, Sullivan SD, Fuhlbrigge A, Inui TS for the PAC-PORT II Study Team. A randomized controlled clinical trial to improve asthma care for children through provider education and health systems change: a description of the Pediatric Asthma Care Patient Outcomes Research Team (PAC-PORT II) study design. Health Services and Outcomes Research Methodology. 2005;4:265–282. Zerr DM, Garrison MM, Allpress AL, Heath J, Christakis DA. Infection control policies and hospital-associated infections among surgical patients: variability and associations in a multicenter pediatric setting. Pediatrics. Apr 2005;115(4):e387–e392. Wiehe SE, Garrison MM, Christakis DA, Ebel BE, Rivara FP. A systematic review of school-based smoking prevention trials with long-term follow-up. J Adolesc Health. Mar 2005;36(3):162–169. Wright, JA. A Survey of Provider Satisfaction with an Electronic Prescription Writer in Three Ambulatory Pediatric Settings; Missed Opportunities to Prescribe Controllers for Children with Persistent Asthma; Randomized Trial of Tailored Guideline-Based Electronic Decision Support: Can Computers Help Pediatricians Prescribe Controllers for Persistent Asthma?; Using a Tablet Computer to Gather Health Information 110 Exposure and Interest in Information to Reduce Asthma Triggers in Children. Abstracts submitted to Pediatric Academic Societies. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Zimmerman FJ, Christakis DA. Children’s television viewing and cognitive outcomes: a longitudinal analysis of national data. Arch Pediatr Adolesc Med. Jul 2005;159(7):619–625. Zimmerman FJ, Glew GM, Christakis DA, Katon W. Early cognitive stimulation, emotional support, and television watching as predictors of subsequent bullying among grade-school children. Arch Pediatr Adolesc Med. Apr 2005;159(4):384–388. Genetics and Developmental Medicine The Division of Genetics and Developmental Medicine (in the Department of Pediatrics) is committed to providing excellence in clinical care, education and research related to a broad spectrum of genetic disorders, birth defects and developmental disabilities. Approximately 3 percent to 5 percent of all newborns will have one of these conditions or some related problem that may seriously influence the quality of the patients’ and their families’ lives. The division is one of the largest in the United States and is the oldest and most recognized referral center of its type in the Pacific Northwest. Through an extensive network of outreach clinics we also provide outpatient care to children in the WAMI region (Washington, Alaska, Montana, Idaho). Faculty in the division have varied academic backgrounds and are drawn from many disciplines, including human/medical genetics, neurology, developmental/behavioral pediatrics, developmental biology and biochemistry. Through our academic partnerships at the University of Washington, we provide postdoctoral training programs in developmental pediatrics and medical genetics. Our training programs are among the oldest in the country, and many of our alumni hold leadership positions at other institutions. Faculty in the division are involved in many neurodevelopmental research projects, including research into Joubert syndrome and Charcot-Marie-Tooth neuropathy. TEACHING, RESEARCH AND CLINICAL EXPERTISE Phillip F. Chance, MD, is chief of the Division of Genetics and Developmental Medicine, and professor in the Department of Pediatrics at the University of Washington School of Medicine, with a joint appointment as professor in the Department of Neurology. He is the п¬Ѓrst recipient of the Allan and Phyllis Treuer Endowed Chair in Genetics and Development at Seattle Children’s Hospital. Dr. Chance is director of the neurogenetics laboratory in the Department of Pediatrics, which includes trainees, technical staff, and the participation of six full-time faculty. The lab conducts research into the molecular basis of several rare, FACULTY Phillip F. Chance MD, Chief Phillip F. Chance, MD, Chief Michael J. Bamshad, MD Craig L. Bennett, PhD Forrest C. Bennett, MD Shi-Han Chen, PhD Charles A. Cowan, MD Nora E. Davis, MD Daniel A. Doherty, MD, PhD Alan G. Fantel, PhD Ian A. Glass, MD, MBChB neurodevelopmental and neurodegenerative diseases in children, focusing on four main areas: juvenile Lou Gehrig Disease (amyotrophic lateral sclerosis or ALS4), Charcot-Marie-Tooth neuropathy, hereditary neuralgic amyotrophy (HNA, also called familial brachial plexus neuropathy) and Joubert syndrome and related cerebellar malformations. Dr. Chance has published over 80 peer-reviewed articles and communications, and authored 40 book chapters; he lectures frequently on his research. He is a member of the Steering Committee of the university Center for Neurogenetics and Neurotherapeutics. He serves on the medical advisory committees for the Muscular Dystrophy Association, the Charcot-Marie-Tooth Association, the Les Turner Mark C. Hannibal, MD, PhD Anne V. Hing, MD Ronald J. Lemire, MD John F. McLaughlin, MD Daniel G. Miller, MD, PhD William R.A. Osborne, PhD Roberta A. Pagon, MD Melissa A. Parisi, MD, PhD Janine E. Polifka, PhD Michael L. Raff, MD C. Ronald Scott, MD David B. Shurtleff, MD (Emeritus) Katherine A. TeKolste, MD Cristine M. Trahms, MS, RD William O. Walker Jr., MD Stephanie E. Wallace, MD Samuel H. Zinner, MD SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 111 Genetics and Developmental Medicine ALS Association and the Joubert Syndrome Association. He is a regular member of the Cell Death and Injury in Chronic Neurodegeneration (CDIN) Study Section, NINDS/NIH, Bethesda, Md. Michael J. Bamshad, MD, is professor of pediatrics at the University of Washington. His laboratory addresses the origins and afп¬Ѓnities of humans, develops novel strategies to п¬Ѓnd disease susceptibility variants and characterizes genetic variants influencing an assortment of health-related conditions. Dr. Bamshad is particularly interested in genetic variants that cause birth defects, alter risk for chronic diseases of childhood and influence chemosensory perception. His laboratory has identiп¬Ѓed genetic variants that underlie about a dozen different disorders manifested by limb defects, many of which are also characterized by abnormalities of the face, heart, kidneys or genitalia. In 1997 they found that mutations in a gene called TBX3 cause ulnar-mammary syndrome. TBX3 is a member of a family of about 20 so-called T-box genes that play pivotal roles in development of all major organ systems, and which over the past several years have been shown to underlie half a dozen birth defects. Dr. Bamshad’s lab has found mutations in several genes (e.g., TNNI2, TNNT3, TPM2) that encode proteins of the contractile apparatus of fast-twitch myoп¬Ѓbers and cause several syndromes characterized by contractures of the feet and hands. Dr. Bamshad’s clinical interests reflect his research and include human evolutionary biology. Craig L. Bennett, PhD, is research assistant professor of pediatrics at the University of Washington School of Medicine. His research is conducted in the neurogenetics laboratory and is focused in two areas. The п¬Ѓrst is the molecular basis of a juvenile-onset form of motor neuron disease known as amyotrophic lateral sclerosis type 4 (ALS4) that results from mutations of the Senataxin (SETX) gene. In recent work, Dr. Bennett and co-workers generated mammalian expression constructs of wild type SETX and three mutant forms of SETX associated with ALS4. They also found the amount and molecular weight of the SETX protein isolated from ALS4 patient lymphoblasts is approximately equal to that from controls. Most important, they have produced murine ALS4 transgenic founders that will likely prove extremely important to understanding the mechanism leading to motor neuron death resulting from SETX mutations. The second area of research is 112 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Charcot-Marie-Tooth neuropathy type 1C (CMT1C). He has collaborated to show that the SIMPLE protein (which, through mutation, causes CMT1C) interacts with two proteins, NEDD4 and TSG101, that act sequentially in the lysosomal sorting pathway. Their results show that SIMPLE co-localizes with NEDD4 at the plasma membrane and the Golgi apparatus. Forrest C. Bennett, MD, serves as director for the HighRisk Infant Follow-Up Program at the Center for Human Development and Disability at the University of Washington School of Medicine; he is also director of the Pediatrics WAMI (Washington, Alaska, Montana, Idaho) Program and director of the Pediatric Medical Student Program. Dr. Bennett is a member of the university Clinical Curriculum Committee and serves on the Pediatric Residency Committee and the Intern Selection Committee. Dr. Bennett is director of the State of Washington Medical Home Leadership Network and chairman of the Subboard on Developmental-Behavioral Pediatrics for the American Board of Pediatrics. His research includes a Phase IV study looking at the role of early developmental intervention for premature infants. Dr. Bennett is also participating in collaborative studies evaluating the role of nitric oxide in the treatment of neonatal RDS and long-term outcomes, including developmental and chronic lung disease. Dr. Bennett lectures in rehabilitation medicine and in public health and maternal child health courses. He oversees the third-year pediatric clerkship students and approximately 20 fourth-year medical students. He also serves as a mentor to the regional medical student faculty and gives CME lectures in developmental pediatrics at regional and national courses. Shi-Han Chen, PhD, is professor of pediatrics at the University of Washington School of Medicine. Dr. Chen supervises the molecular (DNA) diagnosis lab at Seattle Children’s Hospital. This laboratory processes nearly 1,000 samples per year and in 2004 made about 150 “positive” diagnoses. Dr. Chen recently completed a project that explored the diagnosis, family pedigree and mutation search of a dominant form of congenital stationary night blindness in a large family in China, which was published in 2005 in the Annals of Human Genetics. This project is continuing with a mutation search and п¬Ѓne linkage analysis of the adCSNB on chromosome 3q21 with scientists in China. His other research interests include study of Fragile-X E mental retardation in a three-generation family, P53 network Genetics and Developmental Medicine gene expressions in ischemic and hypoxic hearts and a study of hypoxia in a Tibetan population in conjunction with the Chinese Academy of Sciences. Charles A. Cowan, MD, is developmental pediatrician at Seattle Children’s Hospital and professor of pediatrics at the University of Washington School of Medicine; he works in the Neurodevelopment Clinic at Seattle Children’s and the Autism Clinic in Bellevue, Wash., providing inpatient services and consultation. His work includes resident and medical student teaching on neurodevelopmental topics and supervision of postdoctoral fellows in the Autism Clinic. Dr. Cowan supervises the hospitalist programs at Evergreen Hospital and Providence Evergreen and he serves as medical director for the Kindering Center, a developmental preschool in Bellevue where he volunteers. Dr. Cowan is clinical lead for use of the Pediatric Health Information System (PHIS) database; his work has focused on improved hospital practices for asthma and bronchiolitis. He is also leading an effort at medication reconciliation, a JCAHO national patient safety initiative. Dr. Cowan has recently completed research related to variation and utilization patterns in bronchiolitis. He has additional clinical research in progress looking at bladder augmentation in spina biп¬Ѓda. Dr. Cowan’s clinical interests also include Asperger syndrome and autism disorders. Nora E. Davis, MD, is director of the Apnea Program at Seattle Children’s Hospital and professor of pediatrics at the University of Washington School of Medicine. She just completed a term as medical director of the Boyer Children’s Clinic in Seattle. Dr. Davis is responsible for planning and coordinating students and fellows and for assisting in resident teaching rounds. In addition, she supervises second- and third-year residents on the neurodevelopmental rotation, as well as providing supervision of the University of Washington and Madigan fellows during neurodevelopmental rotations at Seattle Children’s. Dr. Davis is a member of the SIDS Foundation of Washington, where she has served as medical advisor, board member and chairman of the Research Committee. She served as president of the Northwest Society for Developmental and Behavioral Pediatrics. Her clinical interests include infant breathing disorders and SIDS. Daniel A. Doherty, MD, PhD, is assistant professor of pediatrics at the University of Washington School of Medicine. He is a developmental pediatrician working with a group of doctors in the neurogenetics laboratory that focuses on Joubert syndrome (JS) and related cerebellar malformation disorders. JS is a rare autosomal recessive malformation syndrome involving agenesis of the cerebellar vermis with accompanying brainstem malformations. JS is clinically characterized by the core features of hypotonia, developmental delays, abnormal respiratory patterns and abnormal eye movements; it exhibits variable additional clinical features, and confusion exists regarding its precise deп¬Ѓnition. Genetic locus heterogeneity is likely, and genes crucial to cerebellar and brainstem development are functional JS candidates, particularly homeotic genes specifying the vermian domain. This project involves collecting medical records and blood samples for DNA isolation from multiple families with JS and carrying out a genome-wide scan for regions of halotype sharing in pedigrees with consanguinity. From this data, the goal is to discover mutations leading to JS in speciп¬Ѓc functional and positional candidate genes. Dr. Doherty’s clinical interests include the care of children with brain malformations, prenatal counseling for fetal brain malformations and cultural factors in medical care. Alan G. Fantel, PhD, is professor of pediatrics at the University of Washington School of Medicine. His laboratory has two main interests. His research is focused on the role of free radical formation and toxicity in the genesis of limb reduction anomalies. He is studying the involvement of nitric oxide and its metabolites in these malformations in mice. The laboratory is also the major NIH-funded facility for the collection and distribution of human conceptal tissue to grant-funded institutions. Ian A. Glass, MD, MBChB, is director of the Medical Genetics Program at Seattle Children’s Hospital and co-director of the Alaska Genetics & Birth Defects Clinic. He is associate professor of pediatrics at the University of Washington School of Medicine and holds an adjunct appointment in the Division of Medical Genetics. Seattle Children’s programs provide virtually all of the pediatric genetic services for the states of Washington and Alaska. He also serves on the Genetics Advisory Committee and the Newborn Screening Committee of the Washington state Department SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 113 Genetics and Developmental Medicine of Health. He serves as program leader for a focused research project on Joubert syndrome and related disorders of brain development. It is a collaboration within the neurogenetics laboratory that includes several division faculty. His recent work with this group includes two important discoveries, both of which have been recently reported. The п¬Ѓrst is a description of the NPNH1 gene deletions in patients with a subset of Joubert syndrome. The second relates to a prenatal diagnosis imaging protocol for Joubert syndrome. Mark C. Hannibal, MD, PhD, is attending physician at Seattle Children’s Hospital and assistant professor of pediatrics at the University of Washington School of Medicine. He is also on associate medical staff in Pediatric Medical Genetics at Seattle Cancer Care Alliance. Dr. Hannibal recently completed research on the clinical and molecular analysis of the Grieg cephalopolysyndactyly and Pallister-Hall syndromes as well as mutations in the SALL4 gene as associated with the Okihiro syndrome. In addition, he is completing a project that relates to the analysis of the susceptibility genes for arthritis in mice. Dr. Hannibal is co-principal investigator in a project studying the molecular basis of hereditary neuralgic amyotrophy, which is his primary research focus. His interest is in the translational aspects of genetic disorders, such as mutations in the Septin 9 gene–associated hereditary neuralgic amyotrophy. He is a member of the Professional Advisory Board for the Kabuki Syndrome Network. Dr. Hannibal’s clinical interests include immunogenetics (primary immunodeп¬Ѓciency) and Kabuki syndrome. Anne V. Hing, MD, specializes in genetics and craniofacial pediatrics at Seattle Children’s Hospital and is assistant professor of pediatrics at the University of Washington School of Medicine. Dr. Hing’s research interests include oculo-oto-facial dysplasia and the genetics of cleft lip and palate. She serves as a Faculty Senate member at the University of Washington and as a member in the Intern Selection Committee at Seattle Children’s. In 2005/2006 she was elected to the Society for Pediatric Research. Dr. Hing also serves as a consultant in medical genetics at Tacoma General Hospital and Central Washington Hospital and at Providence Hospital in Alaska. 114 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Ronald J. Lemire, MD, is director for inpatient services at Seattle Children’s Hospital, which include the Transport Team and the Intensive Care Unit; he is also attending physician in the Birth Defects Clinic. He is professor of pediatrics at the University of Washington School of Medicine. He is a member of the Children’s Hospital Steering Committee, the COO Administrative Staff Committee and the Medical Executive Committee for Children’s Hospital. Dr. Lemire is a chairman of the Honorary Medical Staff Committee and serves on the Review Committee for Airlift Northwest. His committee memberships at Seattle Children’s also include the Capital Equipment Committee and the Intensive Care Unit Leadership Committee. Dr. Lemire serves as an interface between the Harborview Medical Center Trauma System and Seattle Children’s, and he is coordinator for the Flight Service. Dr. Lemire also provides coverage for the medical director of Seattle Children’s and the chair of the Department of Pediatrics. Dr. Lemire’s main research interest is in teratology. With Dr. Tom Shepard, he has recently published the 11th edition of the Catalog of Teratogenic Agents. His research studies have included anencephaly, holoprosencephaly and other aspects related to normal and abnormal development of the human nervous system. Dr. Lemire’s clinical interests include neural tube defects and spinal cord malformations. John F. McLaughlin, MD, is director of the Neurodevelopmental Program at Seattle Children’s Hospital. He is professor of pediatrics at the University of Washington School of Medicine and director of the Clinical Training Unit at the Center on Human Development and Disability (CHDD) at the university. He is principal investigator of the Leadership Education for Neurodevelopmental Disabilities interdisciplinary training grant funded by the Maternal and Child Health Bureau at the CHDD. He is involved in several national committees, including the Data and Safety Monitoring Committee for Management of Myelomeningocele Study at the National Institute for Child Health and Development (NICHD). He is a member of the NIH Task Force on Childhood Motor Disorders at the National Institute for Neurological Disorders and Stroke (NINDS). Dr. McLaughlin is past president and a member of the Therapy Outcomes Committee of the American Academy for Cerebral Palsy and Developmental Medicine. Dr. McLaughlin’s research Genetics and Developmental Medicine includes studies of the long-term effects of selective dorsal rhizotomy and continuous intrathecal baclofen using an implantable pump. He is involved in studies of the incidence of pain and fatigue in persons with cerebral palsy and in developing outcome measures for quality of life. His also works in the Child Development Clinic, the Neurodevelopmental Clinic, the Spasticity Management Clinic and the Alaska Outreach Clinics. He is a member of the Scientiп¬Ѓc Editorial Board for Human Gene Therapy; he is also a member of the Musculoskeletal Tissue Engineering Study Section at the NIH and a member of the Scientiп¬Ѓc Review Board for the National Gene Vector Laboratories also based at the NIH. He has trained numerous post-doctoral fellows. Daniel G. Miller, MD, PhD, is assistant professor at Seattle Children’s Hospital and the University of Washington School of Medicine. Dr. Miller’s research interests include determining how genomic sequences might aberrantly induce large-scale genomic alterations during DNA repair. He uses vectors based on a virus called Adeno-Associated Virus (AAV) to tag genomic locations where DNA double strand breaks are occurring in the human genome. Dr. Miller hypothesizes that these spontaneous breaks may be an initiating event for chromosomal microdeletions observed in patients with genetic syndromes. He completed a large-scale analysis of AAV vector integration sites in primary human cells and identiп¬Ѓed several hotspots where chromosomes spontaneously break. Dr. Miller has also used vectors based on AAV to perform gene targeting in a transgenic mouse model and in bovine embryo п¬Ѓbroblasts as well as other human cell lines. Using these techniques, he is able to modify primary human cell lines to generate mutations similar to speciп¬Ѓc disease states in patients. Dr. Miller’s research also includes several subprojects identifying integration sites of retroviral vectors in the human genome. He does clinical work in the Medical Genetics Clinic. Roberta A. Pagon, MD, is attending physician at Seattle Children’s Hospital and professor of pediatrics and ophthalmology at the University of Washington School of Medicine. She is principal investigator for GeneTests: Genetic Testing Information Resource, the primary Internet-accessible database that helps clinicians identify genetic testing laboratories and apply genetic testing to patient care. She is also collaborating on a Web-based curriculum for primary care residents focused on ethical, legal and social issues related to genetic testing. Dr. Pagon is also collaborating to develop a process to facilitate translation of genetic testing from research laboratories into clinical practice. Dr. Pagon’s clinical interests are hereditary eye disorders and disorders of sexual differentiation. In addition to seeing patients at Seattle Children’s, she attends in the genetics clinics in the Washington State Regional Genetics Program and co-directs the Alaska Genetics Clinic. Dr. Pagon serves on the Board of Directors of the American Society of Human Genetics. She has served as president and a member of the Board of Directors of the American Board of Medical Genetics, as well as serving on the Board of Scientiп¬Ѓc Counselors, the National Human Genome Research Institute and the NIH. William R.A. Osborne, PhD, is research professor of pediatrics and director of Gene Therapy Research at the Center on Human Development and Disability (CHDD) at the University of Washington School of Medicine. His current research is in two areas. The п¬Ѓrst is developing gene transfer therapies to treat cyclic neutropenia in dogs. This research entails the in vivo lentivirus-mediated delivery of canine granulocyte/colony stimulating factor and also its delivery using encapsulated cells. The second area is in gene therapy to treat type 1 diabetes. This work entails the development of speciп¬Ѓc cell lines to secrete insulin and glucagon like peptide 1 for transplantation into diabetic rats. It also involves developing methods permitting implantation of allogeneic islet cells for long-term survival and therapy not requiring immunosuppression. Melissa A. Parisi, MD, PhD, is attending physician at Seattle Children’s Hospital and assistant professor of pediatrics at the University of Washington School of Medicine. Her clinical work is performed primarily through the Medical Genetics Clinic at Seattle Children’s. She also sees patients at the State of Alaska Outreach Clinics, participates in genetics clinics in Bellingham, Wash., and provides consultation at Swedish Hospital in Seattle in genetics and in the neonatal ICU. Areas of special interest include congenital brain disorders and disorders of sexual differentiation. Dr. Parisi is researching the molecular basis of genetic disorders of brain development, particularly involving the hindbrain or cerebellum. She is involved in studies on prenatal diagnosis of cerebellar malformation syndromes. Many of her publications focus on SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 115 Genetics and Developmental Medicine Joubert syndrome and related cerebellar malformations, a group of conditions with a shared feature of the molar tooth sign on MRI. She and her colleagues have recognized that the NPHP1 gene deletion is associated with juvenile nephronophthisis in a subset of individuals with Joubert syndrome. Dr. Parisi is a member of the steering committee for the Puget Sound Women’s Pediatric Society and is chair of the Scientiп¬Ѓc Advisory Board for the Joubert Syndrome Foundation and Related Cerebellar Disorders parent support group. Janine E. Polifka, PhD, is co-director of CARE (Counseling and Advice on Reproductive Exposures) Northwest, a teratogen information service at the University of Washington that receives approximately 70 inquiries per month regarding exposures to drugs and chemicals during pregnancy and lactation. She also manages the TERIS (Teratogen Information System) database, which provides information on the effects of drugs and chemicals on the developing embryo. Recently completed research includes a study of asthma medications in pregnancy and the North American Isotretinoin information and survey line. Current research involves effects of medications for rheumatoid arthritis used during pregnancy. She serves on the PEHSU (Pediatric Environmental Health Specialty Unit) committee, which addresses the concerns of health care professionals and their patients about long- and short-term exposures to environmental contaminants. Dr. Polifka is also on the staff of the Community Outreach & Education Program (COEP) of the Center for Ecogenetics and Environmental Health (CEEH) at the university. Dr. Polifka is a past president of OTIS (Organization of Teratology Information Services), which oversees 19 teratology information services in the United States and Canada. She serves on the Board of Directors, the Meeting Planning Committee and the Research Committee. She also serves on the Public Affairs Committee of the Teratology Society. Michael L. Raff, MD, is attending physician at Seattle Children’s Hospital and assistant professor at the University of Washington School of Medicine. He provides clinical genetics services in the Medical Genetics Clinic and the Telemedicine Genetics Clinic at Seattle Children’s, the Washington State Regional Clinics program, the Skeletal Dysplasia Clinic and the Biochemical Genetics Clinics for the state of Alaska. He is focusing on expanding the Biochemical Genetics Clinics at Seattle Children’s, which he established 116 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON two years ago. Dr. Raff has additional research in progress related to hydroxyacyl CoA dehydrogenase deп¬Ѓciency as well as analysis of pilot projects related to telegenetics. His clinical interests include disorders of mitochondria and peroxisomes, connective tissue disorders. C. Ronald Scott, MD, is director of the biochemical genetics laboratory and of the molecular diagnostic laboratory at Seattle Children’s Hospital — both laboratories were established by Dr. Scott. He heads one of the largest biochemical genetics programs in the US and serves as the metabolic disease consultant at Seattle Children’s and the University of Washington Medical Center. Dr. Scott is director of the Phenylketonuria Clinic at the University of Washington. He serves as advisor on genetics for the Washington state legislature and Department of Health and for the Alaska Department of Health. He is a member of the Genetics Screening Committee for the Paciп¬Ѓc Northwest Regional Genetics Group. He consults with the Mead Johnson Company for the development of special formulas for the management of inborn errors of metabolism. Dr. Scott’s work with the university Department of Chemistry focuses on the application of tandem mass spectrometry in the diagnosis of biochemical disorders; he receives many requests to make presentations on this state-of-the-art undertaking. He also has an open label study with Fabry’s disease entailing the administration of recombinant alpha-galactosidase. Katherine A. TeKolste, MD, is associate professor of pediatrics at the University of Washington School of Medicine. Dr. TeKolste has worked within the Medical Home Leadership Network at the university since 1993 to improve care for children with special health care needs. She participates in many state and regional projects, including the Kids Get Care/Children’s Healthcare Initiative program in King County, Wash. She is project director of the Adolescent Health Transitions Project with the state department of health, which aim to improve transitions for adolescents with disabilities and chronic illnesses. She is also active in regional efforts to improve oral health services for children as part of the Interdisciplinary Children’s Oral Health Promotion (ICOHP) project. She was part of the multi-state team for the recently completed Assuring Better Child Development grant from the Commonwealth Fund and National Academy for State Genetics and Developmental Medicine Health Policy. She worked with regional administrators and providers to pilot developmental screening in the CHILD Proп¬Ѓle mailings to parents of 18-month-olds in Snohomish County. Dr. TeKolste worked on the Infant Health and Development Program (IHDP) multicenter study of premature infants and has served as interim director of the university’s High-Risk Infant Follow-Up Program. Cristine M. Trahms, MS, RD, is senior nutritionist for the Biochemical Genetics Clinic and the Metabolic Genetics Clinic at Seattle Children’s Hospital. She is program director and senior nutritionist for the Phenylketonuria (PKU) Clinic at the University of Washington School of Medicine. She coordinates cooperative educational and support activities, including a live TV downlink to the Spokane PKU Clinic. She serves on the Editorial Board and the Advisory Board for the National PKU News. She also writes a quarterly self-management column, “Just for Kids”, and is reviewer for The Journal of the American Dietetic Association. In addition to many committee and board memberships, Trahms is nutrition discipline leader for the Leadership Education in Neurodevelopmental and Related Disabilities (LEND) training project at the university Center on Human Development and Disability (CHDD). She is a member of the Core Faculty of Nutritional Sciences in the School of Public Health and Community Medicine and co-teaches courses and mentors students. Ms. Trahms developed and continues to reп¬Ѓne and update a regional PKU treatment protocol/manual — which incorporates current evidence-based medical and nutritional care — as well as the PKU Clinic Web site. Trahms has been recognized for Excellence in the Practice of Clinical Nutrition by the American Dietetic Association and named Outstanding Dietitian of the Year by the Washington State Dietetic Association. William O. Walker Jr., MD, is associate professor of pediatrics and director of the Neurogenetics–Birth Defects Clinic at Seattle Children’s Hospital. He works in the outreach clinics at Olympia, Yakima and Aberdeen, Wash., in telemedicine services and in the inpatient service at Children’s Hospital. He is focused on improving coordination of patient care across multiple specialties, especially those involving surgical specialties, in the Neurodevelopmental and Birth Defects Clinic. He also seeks to improve access to neurodevelopmental outpatient services by clarifying services and establishing additional pre-referral guidelines. Dr. Walker is adjunct associate professor of pediatrics within the Uniformed Services University of the Health Sciences, F. Edward Herbert School of Medicine, Bethesda, Md., and frequently lectures at national conferences on spina biп¬Ѓda, metal retardation and developmental disabilities. He serves as fellowship director for Seattle Children’s Developmental Behavioral Pediatrics Scholarship Training Program. He is a member of the Steering Committee of the Children’s Association for Maximum Potential in San Antonio. Dr. Walker has collaborative research projects underway in spina biп¬Ѓda and is participating in a project evaluating the role of assistive devices in promoting health and reducing the onset and severity of secondary conditions in patients with spina biп¬Ѓda. Stephanie E. Wallace, MD, is medical geneticist at Seattle Children’s Hospital and assistant professor at the University of Washington School of Medicine. Her clinical interests include the long-term management of genetic disorders and skeletal dysplasias. Samuel H. Zinner, MD, provides inpatient general pediatric care at Seattle Children’s Hospital and outpatient care services with Seattle’s Children’s Birth Defects Clinic, with the Child Development Clinic at the Center on Human Development and Disability (CHDD) and with the Autism Center at the CHDD. He is assistant professor of pediatrics at the University of Washington; he is also assistant director of fellowship training and director of residency training in developmental and behavioral pediatrics. Dr. Zinner pursues clinical and research interests with a strong focus on psychosocial and behavioral aspects of neurodevelopment. He has a particular interest in Tourette syndrome and its associated conditions, including attention deп¬Ѓcit disorders, learning disabilities, obsessive-compulsive symptoms, sleep disturbances and others. He is working to develop an interdisciplinary Tourette syndromeВ¬based clinic for consultation, management and research. His current research activities include enhancement of “Medical Home” capabilities for community providers via improved access to, and awareness of, available resources. Dr. Zinner is a member of the medical advisory board for the national Tourette Syndrome Association. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 117 Genetics and Developmental Medicine AWARDS AND HONORS Ian A. Glass, MD Listed in “Best Doctors 2005,” Seattle magazine Elected to the Society for Pediatric Research Anne V. Hing, MD Elected to the Society for Pediatric Research Ronald J. Lemire, MD Lemire Endowed Lectureship in Teratology Who’s Who in America Roberta A. Pagon, MD Listed in “Best Doctors,” Seattle magazine, 2005 Implantable System Performance Registry (ISPR), Medtronic, Inc, $91,975 William R.A. Osborne, PhD MTCC - Osborne Pilot, NIDDK/NIH, $75,800 Roberta A. Pagon, MD Rare Disease Research Test Translation to Clinical Testing, NIH/DHHS, $74,007 GeneClinics: Clinical Genetic Testing Resource, NLM/NIH, $1,300,000 C. Ronald Scott, MD PKU Clinic, Health Services Administration, $244,822 RESEARCH FUNDING William O. Walker Jr., MD Effectiveness of Bowel and Bladder Management Techniques on Children with Spina Biп¬Ѓda, Children’s Hospital, Los Angeles, Association of University Centers on Disabilities-National Center on Birth Defects and Developmental Disabilities Cooperative Agreement, $54,420 New Continuing Craig L. Bennett, PhD CMTIC: Possible Defects in PMP22 Regulation Due to SIMPLE Mutations, Muscular Dystrophy Association, $100,000 Phillip F. Chance, MD Identiп¬Ѓcation and Characterization of the ALS4 Gene, NINDS/NIH, $288,040 William O. Walker Jr., MD Outstanding Teacher Award, University of Washington Pediatric Residency Program, 2005 Mutations in the ALS4 Gene (SETX) May Alter RNA Processing in Motor Neurons, Robert Packard Center for ALS Research at Johns Hopkins, $81,000 Phillip F. Chance, MD Molecular Basis of Hereditary Neuralgic Amyotrophy, NINDS/NIH, $323,634 Alan G. Fantel, PhD Laboratory of Developmental Biology, NICHD/NIH, $377,329 Mark C. Hannibal, MD, PhD Analysis of Susceptibility Genes for Arthritis in Mice, NIAMS/NIH, $119,210 Daniel G. Miller, MD, PhD Mechanisms of Cellular Transduction with AAV Vectors, NIDDK/NIH, $125,253 William R.A. Osborne, PhD Insulin Gene Therapy of Type 1 Diabetes, NIDDK/ NIH, $201,628 Canine G-CSF Gene Transfer, NIDDK/NIH, $248,624 Ian Glass, MD, MBChB Genetic Analyses of Cerebellar Malformations, University of Washington, National Institute of Child Health and Development/NIH, $94,153 John F. McLaughlin, MD Leadership Education in Neurodevelopmental/Related Disabilities, MCHB/HRSA, $818,000 118 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Melissa A. Parisi, MD, PhD Molecular Basis of Joubert Syndrome and Related Diseases, NINDS/NIH, $166,271 Genetics and Developmental Medicine C. Ronald Scott, MD Treatment of Tyrosinemia-I with NTBC, FDA, $158,572 Lysosomal Registries, Genzyme, $200,000 Mass Spec, Genzyme, $179,562 Katherine A. TeKolste, MD Adolescent Health Transition Project, WA DOH/ DHHS, $70,000 Samuel H. Zinner, MD Descriptive Study of Tourette Syndrome: Quality of Life, AUCD/CDC, $190,351 TEACHING AND PRESENTATIONS Phillip F. Chance, MD Hereditary Neuropathies Including Charcot-MarieTooth Disease, Genetics in Neurology, American Academy of Neurology, Miami, April 2005 Clinical and Genetic Evaluation of Patients with Inherited Peripheral Nerve Disorders, neurology Grand Rounds, Tufts University School of Medicine/New England Medical Center, Boston, June 2005 Nora E. Davis, MD Bedside Teaching - A3 General Pediatrics, Neurodevelopmental Medicine, Apnea Program, Seattle Children’s Teaching Materials for Parents and Professionals, Apnea Program, Seattle Children’s Daniel A. Doherty, MD, PhD Mental Retardation, Rehab 400: Medical Science, University of Washington School of Medicine Ian A. Glass, MD, MB ChB Genotype-Phenotype Correlations in Joubert Syndrome and the Relative Contribution of NPHP1 and AHI1 Gene Mutations to the Disorder, American College of Medical Genetics annual meeting, Grapevine, Texas, March 19, 2005 Spectrum of Phenotypic Findings in Individuals with Joubert Syndrome and Clinical Correlation with Identiп¬Ѓed Mutations in the NPHP1 and AHI1 Genes, David W. Smith Annual Workshop on Malformations and Morphogenesis, Iowa City, Iowa, August 2–6, 2005 AHI1 Mutations Cause Both Retinal Dystrophy and Renal Cystic Disease in Joubert Syndrome, poster presentation, American Society of Human Genetics, 55th Annual Meeting, Salt Lake City, October 25–29, 2005 Joubert Syndrome: A Paradigm for Prenatal Diagnosis of Speciп¬Ѓc Hindbrain Malformations by Ultrasound and MRI, poster presentation, American Society of Human Genetics 55th annual meeting, Salt Lake City, October 25–29, 2005 Anne V. Hing, MD Genetic Assessment of Craniofacial Anomalies, orthodontic resident lecture, University of Washington, November 17, 2005 John F. McLaughlin, MD Raising Special Needs Kids: Health, Growth, & Nutrition, Duncan Seminar, Seattle, March 18, 2005 Cerebral Palsy: Physical Medicine and Rehabilitation Board Review Course, University of Washington, April 8, 2005 Child with Cerebral Palsy and Role of Developmental Pediatrics, annual talks, Center for Human Development and Disability, Seattle, 2005 Roberta A. Pagon, MD Course 2AC.001: Genetic Testing in Clinical Neurology, American Academy of Neurology, Miami, April 10, 2005 Melissa A. Parisi, MD, PhD An Approach to the Dysmorphic Child, noon conference presentation, University of Washington Congenital Malformations of the Human Forebrain; Congenital Malformations of the Human Hindbrain, Ipokrates Conference: New Frontiers in Neonatology, Innsbruck, Austria, March 1, 2005 Boy or Girl? A Genetics Approach to Ambiguous Genitalia, Urology Conference, Seattle Children’s, September 6, 2005 AHI1 Mutations Cause Both Retinal Dystrophy and Renal Cystic Disease in Joubert Syndrome, poster presentation, American Society of Human Genetics 55th annual meeting, Salt Lake City, October 25–29, 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 119 Genetics and Developmental Medicine A Gender Assessment Team: Experience with 217 patients Over a Period of 23 Years, American College of Medical Genetics Annual Meeting, Grapevine, Texas, March 17, 2005 Genotype-Phenotype Correlations in Joubert Syndrome and the Relative Contribution of NPHP1 and AHI1 Gene Mutations to the Disorder, American College of Medical Genetics Annual Meeting, Grapevine, Texas, March 19, 2005 Spectrum of Phenotypic Findings in Individuals with Joubert Syndrome and Clinical Correlation with Identiп¬Ѓed Mutations in the NPHP1 and AHI1 Genes, David W. Smith Annual Workshop on Malformations and Morphogenesis, Iowa City, Iowa, August 2–6, 2005 Developmental Screening and Surveillance Through CHILD Proп¬Ѓle Health Promotion, Philanthropy Northwest, March 14, 2005 Community Partners in Developmental Surveillance, panel moderator, Children’s Preventive Healthcare Initiative, March 22, 2005 Child Development for Dentists, Pediatric Dentistry Residents’ Seminar, University of Washington, August 4, 2005 Congenital Malformations of the Posterior Fossa: New Perspectives in Embryological Classiп¬Ѓcation, Intensive Workshop on Fetal and Congenital Anomalies, Bari, Italy, December 2, 2005 Cristine M. Trahms, MS, RD A Shared Management Model: Parents and Providers Promoting Shared Management of Chronic Conditions in Children, 26th Annual Duncan Seminar, March 2005 Janine E. Polifka, PhD Breast Milk Contaminant, Controversies & Advances in Pediatric Environmental Health, Seattle, April 1, 2005 Assessment of Physical Growth: Using the CDC and Specialized Growth Charts, Duncan Seminar, Seattle Children’s, March 2005 David B. Shurtleff, MD Symptomatic Cerebellar Tonsil Ectopia in Lipomyelomeningocele Patients, Society for Research into Hydrocephalus and Spina Biп¬Ѓda 49th Annual Scientiп¬Ѓc Meeting, Barcelona, Spain, July 1, 2005 The Bridge from Pediatric To Adult Care: Our Clinical Experience, 10th Ross Metabolic Conference, Atlanta, Ga., April 2005 Obesity and BMI in Myelomeningocele Patients, Society for Research into Hydrocephalus and Spina Biп¬Ѓda 49th Annual Scientiп¬Ѓc Meeting, Barcelona, Spain, July 2, 2005 Katherine A. TeKolste, MD Adolescent Transition, CSHCN Nurses, Southwest Region, January 10, 2005 Developmental Surveillance and Screening, Children’s Preventive Healthcare Initiative Collaborative Meeting, January 25, 2005 Adolescent Transition, CSHCN Nurses, Northwest Region, February 10, 2005 120 Dental Issues in Children with Special Health Care Needs, pediatric dentistry residents seminar, University of Washington, February 17, 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Assuring Pediatric Nutrition in the Hospital and Community, Seattle, June 22–24, 2005 William O. Walker Jr., MD School Readiness, North Paciп¬Ѓc Pediatric Society 171st Scientiп¬Ѓc Conference, Blaine, Wash., August 2005 Mental Retardation: It’s Not Just A Number Anymore! Instructional Course, 59th Annual Meeting, American Academy for Cerebral Palsy and Developmental Medicine, Orlando, Florida, September 2005 Mental Retardation: It’s Not Just a Number Anymore!, 6th Annual Pediatric Conference, Madigan Army Medical Center, Tacoma, Wash., October 2005 Samuel H. Zinner, MD Tourette Syndrome: Past, Present & Future, 28th Annual Advanced Practice in Primary & Acute Care, Seattle, October 2005 Genetics and Developmental Medicine National Ground Round Series, Centers for Disease Control/Tourette Syndrome Association Partnership: Oregon Health & Science University, Portland, Ore., March 2005; Duke University Medical Center, Durham, N.C., May 2005; University of South Dakota School of Medicine, Billings, Mont., November 2005 Autism Spectrum Disorders: A Medical Approach, University of Washington Autism Center, August 2005 Bennett FC. Developmental outcome. In: Avery’s Neonatology, Pathology and Management of the Newborn, Sixth Edition. MacDonald MG, Mullett MD, Seisha MMK, eds. Philadelphia: Lippincott, Williams and Wilkins, 2005. Beutler E, Gelbart T, Scott CR. Hematologically important mutations: Gaucher disease. Blood Cells Mol Dis. 2005;35:355–364. Tourette Disorder and Comorbid Conditions, Learning Disabilities, Interviewing Families, Health and Wellness for Teens Living with Disabilities, Autism Spectrum Disorders – A Medical Approach, Speech and Language Delays, Normal Behavior and Development (three-part series), lectures to fellows, residents, medical students and other disciplines, University of Washington, 2005 Chance PF. Hereditary neuropathy with liability to pressure palsies. In: Neurological Therapeutics: Principles and Practice. Noseworthy J, ed. London: Martin Dunitz, 2005. PUBLICATIONS Davis BE, Dillon CM, Shurtleff DB, Duguay S, Seidel KD, Ellenbogen RG, Joeser JD. Long-term survival of patients with myelomeningocele. Pediat Neurosurg. 2005;41:186–191. Alwan S, Polifka JE, Friedman JM. Addendum: Sartan treatment during pregnancy. Birth Defects Res A Clin Mol Teratol. 2005;73:904–905. Alwan S, Polifka JE, Friedman JM. Angiotensin II receptor antagonist treatment during pregnancy. Birth Defects Res A Clin Mol Teratol. 2005;73:123–130. Andersson HC, Charrow J, Kaplan P, Mistry P, Pastores GM, Prakesh-Cheng A, Rosenbloom BE, Scott CR, Wappner RS, Weinreb NJ. Individualization of long-term enzyme replacement therapy for Gaucher disease. Genet Med. 2005;7:105–110. Bamshad M. Genetic influences on health: does race matter? J Am Med Assoc. 2005;294:937–946. Barry S, Brzezinski M, Yanay O, Seppen JE, Osborne WRA. Sustained elevation of neutrophils in rats induced by lentivirus-mediated G-CSF delivery. J Genet Med. 2005;7:1510–1516. Bennett CL, Huynh HM, Barnett KL, Chance PF, Glass IA, Gospe SM Jr. Genetic heterogeneity for autosomal recessive pyridoxine-dependent seizures. Neurogenetics. 2005;6:143–149. Christakis DA, Cowan CA, Garrison MM, Molteni R, Marcuse E, Zerr DM. Variation in inpatient diagnostic testing and management of bronchiolitis. Pediatrics. 2005;115:878–884. Doherty D, Glass IA, Siebert JR, Strouse PJ, Parisi MA, Shaw DW, Chance PF, Barr M Jr, Nyberg D. Prenatal diagnosis in pregnancies at risk for Joubert syndrome by ultrasound and MRI. Prenat Diagn. 2005;25:442–447. Elstein D, Scott CR, Zeigler M, Abrahamov A, Zimran A. Phenotypic heterogeneity in patients with Gaucher disease and the N370S/V394L genotype. Genet Test. 2005;9:26–29. Ferri R, Chance PF. Lorenzo’s oil: advances in the treatment of neurometabolic disorders. Arch Neurol. 2005;62:1045–1046. Gonzalez E, Kulkarni H, Bolivar H, Mangano A, Sanchez R, Catano G, Nibbs RJ, Freedman BI, Quinones MP, Bamshad MJ, Murthy KK, Rovin BH, Bradley W, Clark RA, Anderson SA, O’Connell RJ, Agan BK, Ahuja SS, Bologna R, Sen L, Dolan MJ, Ahuja SK. The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. Science. 2005;307:1434–1440. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 121 Genetics and Developmental Medicine Hannibal MC, Chance PF. CMT2, dominant intermediate CMT and CMTX. In: Hereditary Peripheral Neuropathies. Kuhlenbaumer G, Stogbauer FD, Ringelstein B, Young P, eds., Berlin: Springer-Verlag, 2005. Johnston JJ, Olivos-Glander I, Killoran C, Elson E, Turner JT, Peters KF, Abbott MH, Aughton DJ, Aylsworth AS, Bamshad MJ, Booth C, Curry CJ, David A, Dinulos MB, Flannery DB, Fox MA, Graham JM, Grange DK, Guttmacher AE, Hannibal MC, Henn W, Hennekam RC, Holmes LB, Hoyme HE, Leppig KA, Lin AE, Macleod P, Manchester DK, Marcelis C, Mazzanti L, McCann E, McDonald MT, Mendelsohn NJ, Moeschler JB, Moghaddam B, Neri G, Newbury-Ecob R, Pagon RA, Phillips JA, Sadler LS, Stoler JM, Tilstra D, Walsh Vockley CM, Zackai EH, Zadeh TM, Brueton L, Black GC, Biesecker LG. Molecular and clinical analyses of Greig cephalopolysyndactyly and PallisterHall syndromes: robust phenotype prediction from the type and position of GLI3 mutations. Am J Hum Genet. 2005;76:609–622. Jorde LB, Carey JC, Bamshad MJ, Raymond L, White RW. Medical Genetics, 3rd Edition (revised), Mosby, 2005. Karafet TM, Lansing JS, Redd AJ, Reznikova S, Watkins JC, Surata SP, Arthawiguna WA, Mayer L, Bamshad MJ, Jorde LB, Hammer MF. Balinese Y-chromosome perspective on the peopling of Indonesia: genetic contributions from pre-Neolithic huntergatherers, Austronesian farmers, and Indian traders. Hum Biol. 2005;77:93–114. Kapur RP, Clarke CM, Doggett B, Taylor BE, Baldessari A, Parisi MA, Howe DG. Hox11L1 expression by precursors of enteric smooth muscle: an alternative explanation for megacecum in HOX11L1-/- mice. Pediatr Dev Pathol. 2005;8:148–161. Kuhlenbaumer G, Hannibal MC, Nelis E, Schirmacher A, Verpoorten N, Meuleman J, Watts GD, De Vriendt E, Young P, Stogbauer F, Halfter H, Irobi J, Goossens D, Del-Favero J, Betz BG, Hor H, Kurlemann G, Bird TD, Airaksinen E, Mononen T, Serradell AP, Prats JM, Van Broeckhoven C, De Jonghe P, Timmerman V, Ringelstein EB, Chance PF. Mutations in SEPT9 cause hereditary neuralgic amyotrophy. Nat Genet. 2005;37:1044–1046. 122 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Lemire RJ. J. Bruce Beckwith: scholar, п¬Ѓsherman and friend. Pediatric Developmental Pathology. 2005;8:270–281. Ligon AH, Moore SD, Parisi MA, Mealiffe ME, Harris DJ, Ferguson HL, Quade BJ, Morton CC. Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas. Am J Hum Genet. 2005;76:340–348. McLaughlin JF, Felix SD, Nowbar S, Bjornson KF, Hays RM. Lower extremity sensory function in children with cerebral palsy. Pediatric Rehabilitation. 2005;8:45–52. Miller DG, Trobridge GD, Petek LM, Jacobs MA, Kaul R, Russell DW. Large-scale analysis of adeno-associated virus vector integration sites in normal human cells. J Virol. 2005;79:11434–11442. Pagon RA. Genetic testing: when to test, when to refer. Am Fam Physician. 2005;72:33–34. Parisi MA, Doherty D, Eckert ML, Shaw DW, Ozyurek H, Aysun S, Giray O, Al Swaid A, Al Shahwan S, Dohayan N, Bakhsh E, Indridason OS, Dobyns WB, Bennett CL, Chance PF, Glass IA. AHI1 mutations cause both retinal dystrophy and renal cystic disease in Joubert syndrome. J Med Genet. 2005; e-publication. Parisi MA, Lipman NS, Clarke CM, Taylor B, Kapur RP. Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudo-obstruction. J Pediatr Surg. 2005;40:1760–1765. Pleasure DE, Chance PF. Neurotrophin-3 therapy for Charcot-Marie-Tooth disease type 1A. Neurology. 2005;65:662–663. Robertson J, Polifka JE, Avner M, Chambers C, Delevan G, Koren G, Lavigne SV, Martinez LP, Miller RK, Carey JC. A survey of pregnant women using isotretinoin. Birth Defects Res A Clin Mol Teratol. 2005;73:881–887. Scott CR. Newborn screening for lysosomal storage disorders. Clinical Perspectives. 2005;12:11–15. Genetics and Developmental Medicine Shirk AJ, Anderson SK, Hashemi SH, Chance PF, Bennett CL. SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease. J Neurosci Res. 2005;82:43–50. Shriver MD, Mei R, Parra EJ, Sonpar V, Halder I, Tishkoff SA, Schurr TG, Zhadanov SI, Osipova LP, Brutsaert TD, Friedlaender J, Jorde LB, Watkins WS, Bamshad MJ, Gutierrez G, Loi H, Matsuzaki H, Kittles RA, Argyropoulos G, Fernandez JR, Akey JM, Jones KW. Large-scale SNP analysis reveals clustered and continuous patterns of human genetic variation. Hum Genomics. 2005;2:81–89. Shurtleff DB, Sobkowiak AC, Walker W. Transition/ separation, toilet training, and sexuality. In: Neural Tube Defects: From Origin to Treatment. Wyszynski D, ed., New York, London: Oxford University Press, 2005:293–306. Slavotinek A, Parisi MA, Heike C, Hing A, Huang E. Craniofacial defects of blastogenesis: duplication of pituitary with cleft palate and oropharyngeal tumors. Am J Med Genet A. 2005;135:13–20. Warren SF, Batshaw M, Bennett FC, Hagerman R, Seltzer M. Biomedical research for primary and secondary prevention. In: National Goals and Research for People with Intellectual and Developmental Disabilities. Lakin C, Turnbull A, eds. Washington, D.C.: American Association on Mental Retardation, 2005. Watkins WS, Prasad BV, Naidu JM, Rao BB, Bhanu BA, Ramachandran B, Das PK, Gai PB, Reddy PC, Reddy PG, Sethuraman M, Bamshad MJ, Jorde LB. Diversity and divergence among the tribal populations of India. Ann Hum Genet. 2005;69:680–692. Wood ET, Stover DA, Ehret C, Destro-Bisol G, Spedini G, McLeod H, Louie L, Bamshad M, Strassmann BI, Soodyall H, Hammer MF. Contrasting patterns of Y chromosome and mtDNA variation in Africa: evidence for sex-biased demographic processes. Eur J Hum Genet. 2005;13:867–76. Wooding S, Stone AC, Dunn DM, Mummidi S, Jorde LB, Weiss RK, Ahuja S, Bamshad MJ. Contrasting effects of natural selection on human and chimpanzee CC chemokine receptor 5. Am J Hum Genet. 2005;76:291–301. Slavotinek AM, Tanaka J, Winder A, Vargervik K, Haggstrom A, Bamshad M. Acro-dermato-unguallacrimal-tooth (ADULT) syndrome: report of a child with phenotypic overlap with ulnar-mammary syndrome and a new mutation in TP63. Am J Med Genet. 2005;138:146–149. Sze RW, Hopper RA, Ghioni V, Gruss JS, Ellenbogen RG, King D, Hing AV, Cunningham ML. MDCT diagnosis of the child with posterior plagiocephaly. Am J Roentgenol. 2005;185:1342–1346. Trobridge GD, Miller DG, Jacobs MA, Kiem H, Allen JM, Kaul R, Russell DW. Foamy virus vector integration sites in normal human cells. Proc Natl Acad Sci. 2005;103:1498–1503. Wang D, Eadala B, Sadilek M, Chamoles NA, Turecek F, Scott CR, Gelb MH. Tandem mass spectrometric analysis of dried blood spots for screening of mucopolysaccharidosis I in newborns. Clin Chem. 2005;51:898–900. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 123 Hematology/Oncology and Bone Marrow Transplant Seattle Children’s Hospital, Fred Hutchinson Cancer Research Center (FHCRC) and the University of Washington Medical Center bring together their adult and pediatric oncology programs in the Seattle Cancer Care Alliance (SCCA). Seattle Children’s is a nationally recognized leader in pediatric cancer diagnosis and treatment, and the Division of Hematology/Oncology and Bone Marrow Transplant (in the Department of Pediatrics) provides the pediatric cancer care for the SCCA. The dedicated pediatric specialists in our 33-bed SCCA inpatient unit care for over 240 new patients each year. Our multidisciplinary approach to treatment offers real advantages to our patients. A diverse group of experienced pediatric specialists, present in one location and focused on the care of children, is able to deliver the best possible treatments. Members of our team include oncologists, surgeons, midlevel practitioners, nurses, nutritionists, social workers and child life specialists working in inpatient and outpatient settings. The Hematology/Oncology Clinic offers multiple specialty services, including a bone tumor clinic, bone marrow transplant services, hematologic and sickle cell disease clinics, multidisciplinary solid tumor oncology clinic, neuro-oncology clinic, surgical oncology care, palliative care and radiation therapy. Whenever possible, we treat our patients with the Children’s Oncology Group protocols approved by our review board, which include investigational therapy or drugs when there are no effective standard therapies for a given diagnosis. We offer long-term follow-up through the ACCESS (After Cancer Care Ends, Survivorship Starts) program, which helps pediatric cancer survivors live healthy lives, and through the Long-Term Follow-up program, which evaluates effects after hematopoietic cell transplant. Based on our overall dedication to improving survival rates for children with brain tumors, the depth of our program, the clinical resources of our institution and our ability to perform innovative research, Seattle Children’s was one of nine institutions in the United States selected for membership in the Pediatric Brain Tumor Consortium. Our research activities to improve cancer treatment encompass internationally recognized programs at Children’s, the University of Washington and FHCRC. These activities have been responsible for the development of widely used clinical treatments, including hematopoietic stem cell transplant and a new targeted therapy for treating acute myelogenous leukemia. TEACHING, RESEARCH, AND CLINICAL EXPERTISE Irwin D. Bernstein, MD, is chief of the Division of Hematology/Oncology and Bone Marrow Transplant at Seattle Children’s Hospital and professor of pediatrics at the University of Washington School of Medicine. He is director of the Division of Pediatric Hematology/ Oncology in the university Department of Pediatrics and head of the Pediatric Oncology Program at Fred Hutchinson Cancer Research Center (FHCRC). Dr. Bernstein holds the John R. Hartmann Endowed Chair in Pediatric Oncology/Hematology at Seattle Children’s and is an American Cancer Society Clinical Research Professor. He has been a board member for the Leukemia & Lymphoma Society, is chairman of the society’s 124 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Professional Education Committee, and is a member of the Scientiп¬Ѓc Advisory Board for the University of Minnesota Cancer Center. Dr. Bernstein’s research interests include hematopoietic stem cells, antibody targeted therapies for lymphoma and leukemia, and the biology of acute myeloid leukemia. He is principal investigator on a Leukemia & Lymphoma Society SCOR program in immunotherapy of hematologic malignancies, on multiple grants from the National Institutes of Health (NIH), including the Children’s Oncology Group AML reference laboratory, and on a Program Project Grant studying the biology of hematopoietic stem cells. Additional NIH grants support his studies of acute myeloid leukemia cells — which have led to the development of Mylotarg, a drug widely used for treating acute Hematology/Oncology and Bone Marrow Transplant myelogenous leukemia — and his current studies of hematopoietic stem cell — which have led to a novel approach for expanding stem cell numbers in cord blood that will be tested in a clinical trial to improve cord blood transplant. Dr. Bernstein also heads NIH-supported grants for career development in pediatric and medical oncology, and for the Pediatric Oncology Research Training Program. Robert G. Andrews, MD, is attending physician at Seattle Children’s Hospital and associate professor in the Division of Pediatric Hematology/Oncology at the University of Washington School of Medicine. He is associate member of Fred Hutchinson Cancer Research Center (FHCRC) in the Clinical Research Division, and head of stem cell and transplant biology at the Washington National Primate Research Center. Dr. Andrews has research interest in hematopoietic stem cell and transplant biology, including gene therapy and expansion of hematopoietic stem cells as well as fetal stem cell transplant and embryonic stem cell–based therapies. His laboratory is studying novel nonhuman primate embryonic stem cell (ESC) lines to characterize the differentiation to hematopoietic stem cells (HSC) and to develop strategies for the use of ESCderived HSCs for transplant in these pre-clinical models. His work also includes examining the role of natural killer and mesenchymal stem cells in hematopoietic stem cell transplant. Michael A. Bender, MD, PhD, is attending physician at Seattle Children’s Hospital and director of the Odessa Brown Comprehensive Sickle Cell Clinic; he is associate professor at the University of Washington School of Medicine and assistant member of the Clinical Division at Fred Hutchinson Cancer Research Center (FHCRC). Clinically, Dr. Bender has a long-standing commitment FACULTY Irwin D. Bernstein MD, Chief Irwin D. Bernstein, MD, Chief Robert G. Andrews, MD Michael A. Bender, MD, PhD Marie Bleakley, MD, MMSc Lauri M. Burroughs, MD Paul Carpenter, MBBS Mari Dallas, MD Colleen Delaney, MD, MS Debra L. Friedman, MD J. Russell Geyer, MD to hemoglobinopathies with an emphasis on sickle cell disease, and special emphasis on patient education, community outreach and access to health care. He acts as a consultant to the state newborn screening program regarding hemoglobinopathies, providing advice to the state, community physicians and families. Dr. Bender has worked with the Puget Sound Blood Center’s Rare Blood Groups program to increase the number of minority donors by overcoming cultural barriers and improving education and information services; and he received the American Society of Hematology’s Champion for Advocacy award. His research focuses on two main areas: regulation of the chromatin structure in vivo, using the beta-globin locus as a model; and the manipulation of the oxidation/reduction state in vivo to affect sickle cell anemia. Dr. Bender is working on multiple research projects, ranging from developing new techniques to analyze chromatin structure, to establishing a statewide collaborative to provide better support for patients, families, practitioners and community members affected by sickle cell disease. He has used several strategies to delete multiple DNaseI hypersensitive sites (HSs) of the beta-globin locus control region. This region, termed the LCR, is essential for the activation of the locus. Loss of the LCR decreases, but does not eliminate expression, but does not lead to a major change in chromatin structure. As this is different than predicted from analysis of a human with an LCR deletion, two approaches were pursued. The п¬Ѓrst was to extend the deletion further upstream of the LCR. The second was to identify and delete additional candidate regulatory regions from the endogenous locus in mice. Data from several systems has implicated HSs flanking the locus as being important in the regulation of chromatin structure and expression of the locus. Several models have been generated as to the role of these regions. Dr. Bender has recently published the results of these studies, which demonstrate the inaccuracy of several Douglas S. Hawkins, MD Thomas J. Manley, MD prior models for globin gene Dana C. Matthews, MD regulation. He is using Soheil Meshinchi, MD, PhD long-range DNase sensitivJames M. Olson, MD, PhD ity and chromatin immuJulie R. Park, MD noprecipitation studies to Thomas Pendergrass, MD, MSPH further characterize the Jean E. Sanders, MD region through erythroid Barbara Small, MD, MA development, and generate Blythe G. Thomson, MD new models. Ann E. Woolfrey, MD SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 125 Hematology/Oncology and Bone Marrow Transplant Marie Bleakley, MD, MMSc, is attending physician at Seattle Children’s Hospital and in the Clinical Research Division of Fred Hutchinson Cancer Research Center (FHCRC) and acting instructor in pediatrics at the University of Washington School of Medicine. She is a research associate in immunology at FHCRC and attending physician on the bone marrow transplant service. Dr. Bleakley’s primary research focus is the discovery of novel minor histocompatibility antigens expressed on leukemic stem cells. The ability to cure leukemia with allogeneic hematopoietic stem cell transplant requires a type of donor immune cell called a T cell that recognizes and destroys leukemic cells. Some of these T cells can also damage normal cells and cause a condition called graft versus host disease (GVHD). Dr. Bleakley is conducting research to identify the target molecules on leukemic cells that the immune system recognizes, in order to develop immunotherapy for transplant patients that selectively kills leukemic cells without damaging normal cells. Immunotherapy administered in the form of vaccines or T cell infusions could improve the cure rate of patients with advanced leukemia, and early results of this research are very promising. Dr. Bleakley is also developing a clinical protocol for a Phase I trial of selective depletion of speciп¬Ѓc T cell subsets from donor cells for allogeneic hematopoietic stem cell transplant to prevent GVHD. She is the co-principal investigator on a multicenter study to evaluate a new test for diagnosing fungal infections in children undergoing chemotherapy or transplant in order to detect them before they cause harm to the child and when they can be more readily treated. Lauri M. Burroughs, MD, is attending physician at Seattle Children’s Hospital, acting instructor in the Division of Pediatric Hematology/Oncology at the University of Washington School of Medicine and research associate in the Clinical Research Division and in the Pediatric Stem Cell Transplantation Center of Fred Hutchinson Cancer Research Center (FHCRC). Her research interests include hematopoietic cell transplant for patients with primary immunodeп¬Ѓciencies and other nonmalignant inherited disorders, and she has focused her research efforts on reducing transplant-related complications. She is conducting a clinical trial to evaluate whether the addition of the T cell depleting agent CampathВ® can decrease the incidence of graft versus host disease (GVHD) and improve donor chimerism following hematopoietic cell transplantation. 126 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON In addition, in order to increase the number of patients with primary immunodeп¬Ѓciencies and other rare nonmalignant inherited diseases who may beneп¬Ѓt from a transplant, Dr. Burroughs developed a clinical trial for patients who do not have an HLA-matched related or unrelated donor. Patients receiving a nonmyeloablative conditioning regimen will receive cyclophosphamide before and after hematopoietic cell transplantation followed by HLA-haploidentical grafts to remove alloreactive T cells with the goal of improving engraftment and decreasing GVHD. Paul Carpenter, MBBS, is attending physician at Seattle Children’s Hospital and Fred Hutchinson Cancer Research Center (FHCRC) and assistant professor at the University of Washington, with a focus on graft versus host disease (GVHD). He supervises junior attending staff on the pediatric hematopoietic cell transplant service at FHCRC. His local responsibilities include long-standing contributions to the FHCRC Standard Practice Committee and Standard Practice Manual. He chairs a Data Safety Monitoring Board for multiple FHCRC protocols and serves on the FHCRC Scientiп¬Ѓc Review Committee and one of the two Institutional Review Boards. His clinical and research interests focus on GVHD, which is the major and potentially lethal complication of hematopoietic cell transplant. His research continues to explore new therapies for the treatment of acute and chronic GVHD. He is also researching therapies to ameliorate key morbidities associated with chronic immunosuppressive therapies, such as bisphosphonate therapy for glucocorticoidinduced bone disease and the use of statins to treat hyperlipidemia. He recently completed a multicenter pilot study to evaluate the safety and efп¬Ѓcacy of imatinib as post-transplant therapy for high-risk Philadelphia chromosome–positive leukemias. Mari Dallas, MD, is attending physician at Seattle Children’s Hospital, associate in the Clinical Research Division at Fred Hutchinson Cancer Research Center (FHCRC) and acting instructor in the Division of Pediatric Hematology/Oncology at the University of Washington School of Medicine. Dr. Dallas’ research interests center around bone marrow transplant and immune reconstitution afterward, with the goal of improving immune recovery. Her research focuses on the effects of Notch signaling in regulating multiple cell fate decisions by hematopoietic precursors, including the role of Notch in T cell development. Her work in Hematology/Oncology and Bone Marrow Transplant the mouse model demonstrated that murine hematopoietic stem cells cultured on Delta1 reconstituted the T cell compartment more rapidly than non-cultured cells. She is translating her п¬Ѓndings using human umbilical cord blood progenitors. When applied in a clinical setting, augmentation of transplanted umbilical cord blood cells with Delta1 cultured cells may improve clinical outcomes of patients undergoing transplantation by decreasing the transplant-related mortality secondary to infection. Colleen Delaney, MD, MS, is attending physician at Seattle Children’s Hospital, assistant member of the Clinical Research Division of Fred Hutchinson Cancer Research Center (FHCRC) and assistant professor at the University of Washington School of Medicine. She is director of the Cord Blood Transplant Program at FHCRC. Dr. Delaney’s research interests include hematopoietic stem cell regulation and the development of novel and clinically feasible ex vivo expansion systems for hematopoietic progenitor cells using the Notch ligand, Delta1, which is a known regulator of cell fate determination. Her goal is to improve the outcome of patients in need of a cord blood transplant. Dr. Delaney’s research on the role of Notch signaling in hematopoietic stem cell regulation has led to the development of a novel ex vivo expansion system for umbilical cord blood progenitors. Her preclinical data demonstrates not only the ability to expand cord blood progenitor cells ex vivo that retain repopulating ability, but also indicates that the expanded cells may lead to more rapid engraftment as compared to the non-expanded cells and therefore have the potential to overcome delayed engraftment, the major disadvantage after undergoing cord blood transplantation. Dr. Delaney is principal investigator on two multicenter clinical trials investigating the use of single or double unrelated donor umbilical cord blood grafts as an alternative source of stem cells for hematopoietic cell transplant. Debra L. Friedman, MD, is attending physician at Seattle Children’s Hospital and associate professor at the University of Washington Medical Center; she is associate member of the Clinical Research Division at Fred Hutchinson Cancer Research Center (FHCRC) and afп¬Ѓliate investigator in the Division of Public Health Sciences. She is director of the FHCRC Survivorship Program, one of only п¬Ѓve institutions in the nation that are part of the LIVESTRONG Cancer Survivorship Center of Excellence Network, funded by the Lance Armstrong Foundation. She also directs the After Cancer Care Ends, Survivorship Starts (ACCESS) program at Seattle Children’s. She is on the steering committee of the Hodgkin lymphoma, retinoblastoma and late effects committees of the Children’s Oncology Group (COG) and heads a study in each of these areas; she has developed novel therapeutic protocols designed to decrease adverse long-term effects of therapy. She is also co-chair of COG’s Survivorship Transition Task Force and is a nationally recognized expert in cancer survivorship, participating in projects evaluating best practices and models of care. Dr. Friedman is principal investigator on seven projects and supporting investigator on seven additional projects. She is conducting studies on the interaction between environmental exposures and genetic predisposition toward several types of childhood cancer, neuroblastoma, retinoblastoma and Wilms tumor, as well as second malignant neoplasms (SMN). She is investigating a diverse group of physiologic and psychosocial outcomes including health-related quality of life, SMNs, exercise and п¬Ѓtness, endocrinopathies, pulmonary and cardiac dysfunction among survivors of pediatric cancer, hematopoietic stem cell transplant and medical oncology. J. Russell Geyer, MD, is clinical director of the Hematology-Oncology Clinic at Seattle Children’s Hospital and professor of pediatrics and adjunct professor in the Department of Neurological Surgery at the University of Washington School of Medicine. Dr. Geyer holds the Evans Family Endowed Chair in Pediatric Cancer at Seattle Children’s. Nationally, Dr. Geyer is a member of the COG-CNS Brain Tumors Committee and the CNS Steering Committee of the Children’s Oncology Group (COG), the Brain Tumor Strategy Group of the Children’s Cancer Group and the Steering Committee and Quality Assurance Committee of the Pediatric Brain Tumor Consortium (PBTC). Dr. Geyer also serves as chairman of the Seattle Cancer Care Alliance Pediatric Cancer Committee and of the Fred Hutchinson Cancer Research Center Consortium Pediatric Scientiп¬Ѓc Review Committee. He is also COG co-chairman of the Infant Brain Tumor Committee and chairman of the PBTC Phase II brainstem glioma study of Iressa and radiotherapy. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 127 Hematology/Oncology and Bone Marrow Transplant Douglas S. Hawkins, MD, is clinician at Seattle Children’s Hospital and associate professor at the University of Washington School of Medicine. Dr. Hawkins is the principal investigator for the Children’s Oncology Group (COG) activity at Seattle Children’s, associate editor of the Journal of Pediatric Hematology/Oncology and vice chairman of the COG Soft Tissue Sarcoma Committee. He is a member of several COG committees including the Developmental Therapeutics Scientiп¬Ѓc Committee, Bone Tumor Committee and Voting Body Steering Committee. Dr. Hawkins has focused on clinical research, particularly in the treatment of pediatric sarcomas. He has developed a very intensive chemotherapy regimen for metastatic sarcomas, VACIME, and investigated the role of autologous peripheral blood stem cells (PBSC) to support the use of this dose-intensive regimen. He has been principal investigator for two trials of myeloablative therapy for recurrent pediatric sarcomas, using the clinical resources of Fred Hutchinson Cancer Research Center (FHCRC). He is vice chairman and chairman of several other studies. He is focusing on the continued development of targeted radiotherapy for Ewing sarcoma using 166-Holmium-DOTMP, and the design and implementation of a multicenter trial of 166-Holmium-DOTMP for patients with Ewing sarcoma and osseous metastases. Thomas J. Manley, MD, is attending physician at Seattle Children’s Hospital. Dr. Manley has developed a strategy to identify novel CMV antigens targeted by cytotoxic T cells using a CMV cDNA library in an expression-cloning assay. Using this technique he has identiп¬Ѓed 10 genes that encode CMV antigens and he is mapping the epitopes recognized by cytotoxic T cell clones. His planned studies of the function of these cytotoxic T cells using an vitro reactivation model may provide insight into their role in suppressing viral replication, and may support the inclusion of a more diverse repertoire of CMV-speciп¬Ѓc cytotoxic T cells into adoptive immunotherapy trials. He will be using the mutant strain of CMV to study CMV-speciп¬Ѓc immune reconstitution of patients undergoing T cell depleted haploidentical stem cell transplantation, a group of patients at high risk for CMV reactivation and disease. These efforts will provide the basis for future protocols to examine the biology and therapeutic efп¬Ѓcacy of adoptively transferred CMV-speciп¬Ѓc T cell clones. 128 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Dana C. Matthews, MD, is head of the pediatric hemophilia program and provides oversight for clinical hematology at Seattle Children’s Hospital; she is associate professor at the University of Washington and associate member of Fred Hutchinson Cancer Research Center (FHCRC). Clinically, Dr. Matthews supervises all hematology care at Seattle Children’s. Her research interests include risk-based optimization of the treatment of pediatric thrombosis, and clinical aspects of the immune response in patients with hemophilia who develop inhibitors to clotting factor. Dr. Matthews is participating in projects including an effort to characterize immune responses to factor VIII that are signiп¬Ѓcant complications in the management of hemophilia A, providing the clinical correlates for their outcomes, including inhibitor status over time, response to treatment and development of hemophiliarelated complications, and response to immune tolerance. Her primary interest is to improve the outcome for pediatric patients with thrombosis by developing a pediatric thrombosis registry and developing clinical trials for subgroups of patients with thrombosis. She is a member of the board of directors for the newly developing American Thrombosis and Hemostasis Network, a national organization with the mission to “provide stewardship in the development and support of an accessible national database to support excellence in patient care, research, professional mentorship, and public health translation.” Soheil Meshinchi, MD, PhD, is attending physician at Seattle Children’s Hospital, assistant professor at the University of Washington School of Medicine and assistant member of Fred Hutchinson Cancer Research Center (FHCRC), focusing on hematopoietic stem cell transplant. He is co-director of the Children’s Oncology Group (COG) Myeloid Resource Laboratory, vice chair of the COG acute myeloid leukemia (AML) Phase III trial, chairman of the COG committee on the role of RTK activating mutations in pediatric AML. He serves on several COG committees, including the committee for development of new APL therapy, the National Myeloid Disease Steering Committee, Phase III AML committee, Phase II trial of STI571 for Philadelphia chromosome leukemias and the infant leukemia steering committee. Dr. Meshinchi’s clinical and research interests center around the treatment of pediatric myeloid leukemia. He is principal investigator on six research projects at FHCRC and Seattle Children’s including a study on the biology of the alterations of the Hematology/Oncology and Bone Marrow Transplant signal transduction pathway in pediatric cancers, the biology and prognostic implications of FLt3 mutations in AML and the accurate prediction of AML relapse using multidimensional flow cyclometry. He has established a myeloid disease clinic at Seattle Children’s, and he is working to identify novel therapies in AML and to establish the framework to create a proteomic resource laboratory locally and nationally. James M. Olson, MD, PhD, is attending physician at Seattle Children’s Hospital and associate member of Fred Hutchinson Cancer Research Center (FHCRC); he is adjunct associate professor of pathology and associate professor of pediatric hematology/oncology at the University of Washington and on the faculty in the Program in Molecular and Cellular Biology, the Program in Neurobiology and Behavior and the Center for Nanotechnology. He serves as assistant program head of the pediatric oncology program at FHCRC and has mentored more than 30 graduate students and postdoctoral research fellows. He is chair of a national Phase III clinical trial for high-risk medulloblastoma/ PNET patients, a member of the Biology and Translational Research Committee of the Children’s Oncology Group, director of the Hereditary Disease Array Group and a member of the Scientiп¬Ѓc Advisory Board of the Hereditary Disease Foundation. Dr. Olson is principal investigator on six projects that focus on developing effective new therapies for pediatric brain tumors, methods that allow surgeons to better visualize the border of brain cancer and normal brain, the molecular mechanisms of cerebellar development and geneticbased endpoints for neurodegenerative diseases. Julie R. Park, MD, is attending physician at Seattle Children’s Hospital, associate professor in pediatrics at the University of Washington School of Medicine and associate in clinical research at Fred Hutchinson Cancer Research Center (FHCRC). She is director of the pediatric hematology/oncology fellowship at the University of Washington. Dr. Park is an active member of the Children’s Oncology Group (COG) Consortium, coordinating the center’s participation in clinical trials for treatment of neuroblastoma and non-Hodgkin lymphoma and providing leadership for future development of neuroblastoma clinical research within COG. Dr. Park’s primary focus has been investigating new chemotherapy combinations for the initial treatment of high-risk neuroblastoma, a rare but aggressive form of childhood cancer. She has conducted a multicenter clinical trial to determine the feasibility and toxicity of adding topotecan and cyclophosphamide to intensively dosed standard induction agents. She is collaborating to optimize the use of radiation therapy as part of treatment for neuroblastoma. Dr. Park’s work has led to the development of a national randomized Phase III trial within COG for treatment of newly diagnosed high-risk neuroblastoma. Dr. Park has steered our institution into becoming a leading participant in the Phase I Consortium of COG and the New Approaches to Neuroblastoma Therapy (NANT) Consortium. She has been actively involved in the development of novel chemotherapeutic agents that may block critical tumor cell pathways necessary for tumor cell growth or survival. Her research has also focused on developing molecular approaches to optimize the effectiveness of current chemotherapy agents. She is collaborating on an investigation of a possible relationship between a patient’s ability to break down chemotherapy agents and activity against their tumor or risk for development of severe side effects. Thomas W. Pendergrass, MD, MSPH, is director of medical education at Seattle Children’s Hospital; he is professor of pediatrics at the University of Washington School of Medicine and adjunct professor of epidemiology at the School of Public Health, and associate in the Clinical Research Division at Fred Hutchinson Cancer Research Center (FHCRC). He is vice chair for education programs in the Department of Pediatrics at the University of Washington. For Seattle Children’s, he serves as chair for the GME Council, a member of the Medical Record/Medical Informatics Committee, a member of the Hospital Steering Committee and a member for the Children’s Protection Program Quality Advisory Committee. Dr. Pendergrass’ clinical and research interests center around bone and soft tissue sarcomas, retinoblastoma, pediatric hematology, medical education and faculty development. He is interested in the epidemiology and treatment of pediatric thromboses, management of iron overload in chronically transfused patients and treatment of retinoblastoma. His educational focus includes the pediatrics residency and subspecialty curricula, evaluation process, residency program management and continuing medical education. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 129 Hematology/Oncology and Bone Marrow Transplant Jean E. Sanders, MD, is director of the Clinical Pediatric Hematopoietic Transplant Program at Seattle Children’s Hospital and the University of Washington School of Medicine and member of the Clinical Research Division at Fred Hutchinson Cancer Research Center (FHCRC). She is Gerald and Gloria Swanson Endowed Chair in Pediatric Bone Marrow Transplantation. For more than 28 years Dr. Sanders’ work has centered around pediatric hematopoietic stem cell transplant, including the design of transplant preparative regimens for children with acute lymphoblastic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia and other hematologic malignancies, and pediatric solid tumors including neuroblastoma, Ewing sarcoma and aplastic anemia, and other non malignant hematologic disorders. She has also been very involved in donor selection from a matched family member, an unrelated marrow or peripheral blood stem cell donor or an umbilical cord blood donor. Dr. Sanders’ major research focus is in the long-term follow-up issues of children surviving after hematopoietic stem cell transplant, such as chronic graft versus host disease (GVHD), recurrent leukemia, growth and development problems and other late effects. Her studies have demonstrated that some patients who relapse after their п¬Ѓrst transplant may have a successful second transplant, particularly when the п¬Ѓrst transplant preparative regimen was chemotherapy based and the second transplant uses a total body irradiation–based preparative regimen. She is involved in research projects to improve the outcome of allogeneic hematopoietic stem cell transplant in the treatment of hematologic malignancies, to improve ambulatory care of the stem cell transplant recipient and to improve the long-term quality of life for children after marrow transplantation. Her research goals include developing interventions to minimize or treat some of the delayed effects of hematopoietic stem cell transplant, such as using a non-myeloablative preparative regimen for second transplant. Barbara Small, MD, MA, is attending physician at Seattle Children’s Hospital and assistant professor at the University of Washington School of Medicine. She has presented nationally and internationally on issues surrounding end-of-life and quality-of-life decisions. Dr. Small has also taught medical ethics for pediatrics residents and has been a pediatric life support instructor. 130 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Blythe G. Thomson, MD, is clinical associate professor at Seattle Children’s Hospital. She earned her MD magna cum laude from Ohio State University College of Medicine. Locally, she serves on the Cancer Care Committee, Scientiп¬Ѓc Advisory Committee of the General Clinical Research Center, Ambulatory Oversight Committee and Institutional Biosafety Committee of the Seattle Cancer Care Alliance. Dr. Thomson is a member of the Children’s Oncology Group (COG) Stem Cell Transplant Steering Committee, the Institutional Performance Monitoring Committee and the Accreditation Committee of the Foundation for Accreditation of Cellular Therapies. Her clinical and research interests include bone marrow transplant and leukemia research. She is taking a leading role on several research projects including studies relating to possible treatment methods of very high–risk acute lymphoblastic leukemia in children and adolescents, how using Nelarbine in an intensive chemotherapy regimen can affect the treatment of T cell leukemia and local COG studies on high-risk and standard-risk B-precursor acute lymphoblastic leukemia and the classiп¬Ѓcation of acute leukemia. Ann E. Woolfrey, MD, is attending physician at Seattle Children’s Hospital and associate member of the Clinical Research Division at Fred Hutchinson Cancer Research Center (FHCRC). She is director of the Unrelated Marrow Donor Program for the Seattle Cancer Care Alliance. Nationally, she is co-chair of the Center for International Blood and Marrow Transplant Research of the Chronic Leukemia Working Committee, serves on National Marrow Donor Program committees for Histocompatibility and for Transplant Center Contingency Response Planning and is on the Board of Medical Advisors of the Immunodeп¬Ѓciency Foundation. Dr. Woolfrey’s research interests involve pediatric oncology, particularly leukemia, and processes of stem cell, blood and marrow transplant. She is involved in several studies on overcoming genetic barriers in hematopoietic stem cell transplant, identifying nonmyeloablative transplants for nonmalignant disorders and investigating the use of blood stem cell and marrow transplant from HLA-compatible related and unrelated donors. Dr. Woolfrey’s goals include researching nonablative treatments for pediatric diseases, the T cell depletion of peripheral blood stem cells in HLA identical and non-identical transplants and the effectiveness of high-dose therapy for autoimmune diseases. Hematology/Oncology and Bone Marrow Transplant AWARDS AND HONORS Jean E. Sanders, MD Gerald and Gloria Swanson Endowed Chair in Pediatric Bone Marrow Transplantation, awarded 2005 Continuing Robert G. Andrews, MD Transplantation/Stem Cell Biology and Flow Cytometry Resources Core NIH/NCRR, $103,159 Michael A. Bender, MD, PhD Quantitating chromatin dynamics during erythropoiesis, NIH/NIDDK, $259,500 RESEARCH FUNDING New Debra L. Friedman, MD Survivorship Center Grant, LIVESTRONGв„ў/ Lance Armstrong Foundation, $382,701 Soheil Meshinchi, MD, PhD Biology and Prognostic Implication of Flt3 Mutations in AML, NIH/NCI, $242,499 Strategic Partnering to Evaluate Cancer Signatures (subaward), NIH/NCI, $259,972 James M. Olson, MD, PhD Evaluation of Gamma-secretase Inhibitors in Animal and ex vivo Culture Preclinical Models, Merck & Co., Inc., $133,914 Molecular Imaging of Neurons in Brain, Dana Foundation, $60,000 Targeted Therapy in Ex Vivo Medulloblastoma/PNET, NIH/NCI, $226,761 Irwin D. Bernstein, MD Biology of Hematopoietic Stem Cells, NIH/NHLBI, $1,349,459 Career Development in Pediatric and Medical Oncology, NIH/NCI, $537,840 Ex Vivo Replication of Immune Functions of Bone Marrow and Thymus on Three-Dimensional Scaffolds, VaxDesign/US Dept of Interior, $95,692 Human Specimen Banking, NCCF NIH/NCI, $87,955 Immunotherapy of Hematological Malignancies, LLS, $1,377,365 Mechanisms of Resistance to Gemtuzumab Ozogamicin, NIH/NCI, $373,230 Myeloid Leukemia Reference Laboratory, NCCF NIH/NCI, $322,308 Notch Mediated Expansion of Hematopoietic Precursors, NIH/NHLBI, $491,999 Julie R. Park, MD ALS Translational Research for Neuroblastoma, Alex’s Lemonade Stand Foundation, $100,000 Pediatric Oncology Research Training Program, NIH/NCI, $242,003 Children’s Oncology Group — Phase I Consortium, NCCF, NIH/NCI, $50,000 Studies of Normal and Malignant Hematopoiesis, American Cancer Society (ACS), $80,000 Novel Therapies for High-Risk Neuroblastoma, NCI, $131,220 Colleen Delaney, MD, MS Ex Vivo Expansion of Cord Blood Progenitor Cells, Amgen, $60,000 Targeted Hematopoietic Irradiation for Treatment of High Risk Neuroblastoma, CHRMC Endowment, $117,300 Ex Vivo Expansion of Cord Blood Progenitor Cells, NIH/NHLBI, $128,250 Debra L. Friedman, MD Exercise and Fitness in Childhood Cancer Survivors, NIH/NCI, $159,392 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 131 Hematology/Oncology and Bone Marrow Transplant Health Outcomes for Hodgkin Disease Survivors, NIH/NCI, $455,557 Radiation Sensitivity, DNA Repair, and Second Cancers, NIH/NCI, $184,500 Social and Physical Activity of Childhood Cancer Survivors, NIH/NCI, $185,975 TEACHING AND PRESENTATIONS Paul A. Carpenter, MBBS HCT for Severe Aplastic Anemia, pediatric hematology/oncology teaching lecture, Seattle Children’s, April 8, 2005 NIH GVHD Consensus Conference — Supportive Care, podium panel member, Bethesda, Md., June 6, 2005 J. Russell Geyer, MD Pediatric Brain Tumor Clinical Trials Consortium, St. Jude Hospital, NIH/NCI, $94,695 Acute GVHD, pediatric hematology/oncology teaching lecture, Seattle Children’s, July 29, 2005 Douglas S. Hawkins, MD Acute Lymphoblastic Leukemia Research Endowment, Orrico Family, $378,874 Issues in the Management of Chronic GVHD, hematology Grand Rounds (CME activity), University of Chicago, August 1, 2005 Children’s Oncology Group Chair’s Grant, NCCF, NIH/NCI, $263,191 Hematopoietic Cell Transplantation: The Basics, teaching lecture, Seattle Children’s, August 29, 2005 Targeted Radiotherapy for Ewing’s Sarcoma, NIH/NCI, $65,610 Mari Dallas, MD In-Vitro Regulation of Stem Cell Fate by Notch Ligand, Delta1, hematology/oncology Grand Rounds, Seattle Children’s, June 17, 2005 Thomas J. Manley, MD Speciп¬Ѓcity and Function of CMV-speciп¬Ѓc CD8+ T Cells, NIH Continuation $128,250 Soheil Meshinchi, MD, PhD Accurate Prediction of Acute Myeloid Leukemia Relapse Using Multidimensional Flow Cytometry, NIH/NCI, $173,000 Bacterial Infections & Antibiotics Choice in BMT Patients, Seattle Children’s, August 2005 Viral and Fungal Infections in BMT Patients, Seattle Children’s, August 2005 GVHD, Seattle Children’s, August 2005 Prognostic Implications of Flt3 Mutations in AML, NIH/NCI, $100,000 James M. Olson, MD, PhD BHLH Factors in Medulloblastoma Genesis and Maintenance, NIH/NCI, $323,310 Mechanisms of Gene Dysregulation In HD, NIH/ NINDS, $432,500 Molecular Imaging, Diagnosis and Treatment of Medulloblastoma (subaward), NIH/NCI, $77,901 Predicting Retinoid Responsive Medulloblastoma Patient, DRWW, $190,000 The Role of Nmyc in Medulloblastoma Genesis, CHRMC Brain Tumor Foundation, $75,000 132 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Common Conditioning Regimens, Seattle Children’s, August 2005 Colleen Delaney, MD Notch-Mediated Expansion of Cord Blood Progenitors: Development of a Clinically Feasible Ex-Vivo Expansion System, Clinical Research Division seminar, Fred Hutchinson Cancer Research Center, May 20, 2005 Notch-Mediated Expansion of Cord Blood Progenitors: Development of a Clinically Feasible Ex-Vivo Expansion System, Hematology/Oncology Division research seminar, Seattle Children’s, May, 2005 Hematology/Oncology and Bone Marrow Transplant Culture of CD34+ Umbilical Cord Blood Progenitors with Notch Ligand Results in Enhanced and More Rapid Human Engraftment in a Preclinical NOD/SCID Mouse Model, 47th annual meeting, American Society of Hematology, Atlanta, December 12, 2005 Douglas S. Hawkins, MD Pediatric Sarcoma, teaching lecture, University of Washington, October 14, 2005 Childhood Malignancies, teaching lecture, Seattle Children’s dental department, November 7, 2005 Debra L. Friedman, MD Cancer Survivorship, American Society of Pediatric Hematology Oncology annual meeting workshop, 2005 Pediatric Sarcoma, teaching lecture, Seattle Children’s, November 17, 2005 Cancer Survivorship, Seattle Children’s Cancer Committee, 2005 Pediatric Sarcoma, teaching lecture, University of Washington, November 28, 2005 Health-Related Outcomes for Hodgkin Disease Survivors, National Cancer Institute Ofп¬Ѓce of Cancer Survivorship workshop, 2005 Soheil Meshinchi, MD, PhD Children’s Oncology Group Biopathology and Translational Research Symposium and Children’s Oncology Group Biology Conference, invited speaker, COG National Conference, Los Angeles, March 30, 2005 Long-Term Sequelae in Childhood Cancer Survivors: Prevention and Intervention, “Clinical Research at the University of Washington, Pushing Back the Frontiers,” General Clinical Research Center Symposium, University of Washington, 2005 Molecular Mechanisms of Second Malignancies After High-Dose Therapy, transplantation and aging workshop, Seattle Cancer and Aging Program, Fred Hutchinson Cancer Research Center, 2005 Risk-Adapted Therapy for Intermediate-Risk Hodgkin Disease; Health-Related Outcomes for Hodgkin Disease Survivors; and Neoadjuvant Chemotherapy for Group B Retinoblastoma, Children’s Oncology Group biannual meeting, 2005 Risk Factors for Second Malignancies After Transplantation Differ Between Allogeneic and Autologous Recipients, American Society of Hematology annual meeting, 2005 James M. Olson, MD Identifying Vulnerable Pathways in Medulloblastoma, Grand Rounds, University of Michigan Cancer Center, Ann Arbor, March 7, 2005 Jean E. Sanders, MD Stem Cell Transplantation in Children: Current Results and Controversies, Scottsdale, Ariz., January 20, 2005 Ann E. Woolfrey, MD Umbilical Cord Transplantation, American Society for Histocompatibility and Immunogenetics (ASHI) 2005 western regional meeting, Spokane, Wash., 2005 Unrelated Donor and Cord Blood Transplants, MultiCare Health System and Mary Bridge Hematology/Oncology Department, Tacoma, Wash., 2005 PUBLICATIONS Second Malignancies Following Childhood Cancer — An Update, Childhood Cancer Survivor Study annual meeting, 2005 Second Malignancies Following Hematopoietic Stem Cell Transplant, Grand Rounds, University of Minnesota Cancer Center, 2005 Aonzo TA, Wells RJ, Woods WG, Lange B, Gerbing RB, Buxton AB, Neudorf S, Sanders JE, Smith FO, Feig SA. Postremission therapy for children with acute myeloid leukemia. The Children’s Cancer Group experience in the transplant era. Leukemia. 2005;19:965–970. Second Malignant Neoplasms in Hematopoietic Transplant Survivors, Grand Rounds, Fred Hutchinson Cancer Research Center, 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 133 Hematology/Oncology and Bone Marrow Transplant Arceci RJ, Sande J, Lange B, Shannon K, Franklin J, Hutchinson R, Vik TA, Flowers D, Aplenc R, Berger MS, Sherman ML, Smith FO, Bernstein ID, Sievers EL. Safety and efп¬Ѓcacy of gemtuzumab ozogamicin (MylotargВ®) in pediatric patients with advanced CD33+-positive acute myeloid leukemia. Blood. 2005;106(4):1183–1188. Carpenter PA, Lowder J, Johnston L, Frangoul H, Khoury H, Parker P, Jerome KR, McCune JS, Storer B, Martin P, Appelbaum F, Abonour R, Westervelt P, Anasetti C. A phase II multicenter study of visilizumab, humanized anti-CD3 antibody, to treat steroid-refractory acute graft-versus-host disease. Biol Blood Marrow Transplant. 2005;11:465–471. Barker LM, Pendergrass TW, Sanders JE, Hawkins DS. Survival after recurrence of Ewing’s sarcoma family of tumors. J Clin Oncol. 2005;23:4354–4362. Cole PD, Drachtman RA, Smith AK, Cate S, Larson RA, Winick NJ, Hawkins DS, Holcenberg J, Kelly K, Kamen BA. Phase II trial of oral aminopterin for adults and children with refractory acute leukemia. Clin Cancer Res. November 15, 2005. Baron F, Maris MB, Sandmaier BM, Storer BE, Sorror M, Diaconescu R, Woolfrey AE, Chauncey TR, Flowers MED, Mielcarek M, Maloney DG, Storb R. Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning. J Clin Oncol. 2005;23:1993–2003. Blaney SM, Balis FM, Berg S, Arndt CA, Heideman R, Geyer JR, Packer R, Adamson PC, Jaeckle K, Klenke R, Aikin A, Murphy R, McCully C, Poplack DG. Intrathecal mafosfamide: a preclinical pharmacology and phase I trial. J Clin Oncol. 2005;23(7):1555–1563. Bobola MS, Silber JR, Ellenbogen RG, Geyer JR, Blank A, Goff RD. O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines. Clin Canc Res. 2005;11(7):2747–2755. Burroughs L, Mielcarek M, Little M-T, Bridger G, MacFarland R, Fricker S, LaBrecque J, Sandmaier BM, Storb R. Durable engraftment of AMD3100-mobilized autologous and allogeneic peripheral blood mononuclear cells in a canine transplantation model. Blood. 2005;106:4002–4008. Burroughs L, Storb R. Low-intensity allogeneic hematopoietic stem cell transplantation for myeloid malignancies: separating graft-vs.-leukemia effects from graft-vs.-host disease. Curr Opin Hematol. 2005;12:45–54. 134 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Cornetta K, Laughlin M, Carter S, Wall D, Weinthal J, Delaney C, Wagner J, Sweetman R, McCarthy P, Chao N. Umbilical cord blood transplantation in adults: results of the prospective cord blood transplantation (COBLT). Biol Blood Marrow Transplant. Feb 2005;11(2):149–160. Cripe TP, Thomson B, Boat TF, Williams DA. Promoting translation research in academic health centers: navigating the “roadmap.” Acad Med. 2005;80:1012–1018. Dallas MH, Varnum-Finney B, Delaney C, Kato K, Bernstein ID. Density of the notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells. J Exp Med. 2005;201(9):1361–1366. Delaney C, Varnum-Finney B, Aoyama K, BrashemStein C, Bernstein ID. Dose-dependent effects of the notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells. Blood. 2005;106(8):2693–2699. Flowers MED, Traina F, Storer B, Maris M, Bethge WA, Carpenter PA, Appelbaum FR, Storb R, Sandmaier BM, Martin PJ. Serious graft-versus-host disease after hematopoietic cell transplantation following nonmyeloablative conditioning. Bone Marrow Transplant. 2005;3(5):277–282; erratum appears in BMT 2005;3(5):535. Hematology/Oncology and Bone Marrow Transplant Friedman DL. The ovary. In: Survivors of Childhood and Adolescent Cancer, Second Edition. Schwartz CL, Hobbie WL, Constine LS, Ruccione KS, eds. London: Springer Verlag, 2005. Hoffmeister PA, Madtes DK, Storer BE, Sanders JE. Pulmonary function in long-term survivors of pediatric hematopoietic cell transplantation. Pediatric Blood Cancer. Aug 5 2005; e-publication. Friedman DL. Retinoblastoma. In: Manual of Pediatric Hematology/Oncology, Fourth Edition. Lanzkowsky P, ed. Amsterdam: Elsevier, 2005. Friedman DL, Constine LS. Late effects of cancer therapy. In: Pediatric Radiation Therapy, Fourth Edition. Halperin, Constine LS, Tarbell N, eds. Philadelphia: Lippincott Williams and Wilkins, 2005. Kahl C, Leisenring W, Deeg HJ, Chauncey TR, Flowers ME, Martin PJ, Sanders JE, Storb R. Cyclophosphamide and antithymocyte globulin as a conditioning regimen for allogeneic marrow transplantation in patients with aplastic anaemia: a long-term follow-up. Brit J Haematol. Sep 2005;130(5):747–751. Friedman DL, Hilden JM, Powaski K. Issues and challenges in palliative care for children with cancer. Curr Pain Headache Rep. 2005; 9:249–255. Friedman DL, Kadan-Lottick NS, Whitton J, Mertens AC, Yasui Y, Liu Y, Meadows AT, Robison LL, Strong LC. Increased risk of cancer among siblings of long-term childhood cancer survivors: a report from the childhood cancer survivor study. Cancer Epidemiological Biomarkers Preview. 2005;14:1922–1927. Li Y, Bleakley M, Yee C. IL 21 enhances the frequency and afп¬Ѓnity of the antigen-speciп¬Ѓc CD8 T cell response. J Immunol. 2005;175(4):2261–2269. Martin PJ, Friedman DL. How can hematopoietic cell transplant centers and referring physicians help each other during long-term follow-up? Hematology 10, Supplement. 2005;1:250–254. Fries BC, Riddell SR, Kim HW, Corey L, Dahlgren C, Woolfrey AE, Boeckh M. Cytomegalovirus disease before hematopoietic cell transplantation as a risk for complications after transplantation. Biological Blood Marrow Transplant. 2005;11:136–148. Mielcarek M, Burroughs L, Leisenring W, Diaconescu R, Martin PJ, Sandmaier BM, Maloney DG, Maris MB, Chauncey TR, Shizuru JA, Blume KG, Hegenbart U, Niederwieser D, Forman S, Bruno B, Woolfrey A, Storb R. Prognostic relevance of “early-onset” graft-versus-host disease following nonmyeloablative hematopoietic cell transplantation. Br. J. Haematol. 2005;129:381–391. Giaccone L, Martin P, Carpenter PA, Moravec C, Hooper H, Funke VAM, Storb R, Flowers MED. Safety and potential efп¬Ѓcacy of low dose methotrexate for treatment of chronic graft-versus-host disease. Bone Marrow Transplant. 2005;36:337–341. Nemecek ER, Hamlin DK, Fisher DR, Krohn KA, Pagel JM, Appelbaum FR, Press OW, Matthews DC. Biodistribution of yttrium-90 [90Y] labeled anti-CD45 antibody in a nonhuman primate model. Clin Cancer Res. 2005;11:787–794. Goemans BF, Zwaan ChM, Miller M, Zimmermann M, Harlow A, Meshinchi S, Loonen AH, HГ¤hlen K, Reinhardt D, Creutzig U, Kaspers GJL, Heinrich MC. Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia. Leukemia. September 2005;19(9):1536–1542. Sanders JE. Response to Letter to the Editor. Blood. 2005;106:2593. Gross TG, Bucuvalas J, Park J, Greiner TC, Hinrich SH, Kaufman SS, Langnas AN, McDonald RA, Ryckman FC, Shaw BW, Sudan DL, Lynch JC. Low-dose chemotherapy for refractory post-transplant lymphoproliferative disease in children following solid organ transplantation. J Clin Oncol. 2005;23(27):6481–6488. Sanders JE, Guthrie KA, Hoffmeister PA, Woolfrey AE, Carpenter PA, Appelbaum FR. Final adult heights of patients who received hematopoietic cell transplantation in childhood. Blood. 2005;105:1348–1354. Sanders JE, Im HJ, Hoffmeister PA, Gooley TA, Woolfrey AE, Carpenter PA, Andrews RG, Bryant EM, Appelbaum FR. Allogeneic hematopoietic cell transplantation for infants with acute lymphoblastic leukemia. Blood. 2005;105:3749–3756. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 135 Hematology/Oncology and Bone Marrow Transplant Schuetze SM, Rubin BP, Vernon C, Hawkins DS, Bruckner JD, Conrad EU, Eary JF. The use of positron emission tomography in localized, extremity soft tissue sarcoma treated with neoadjuvant chemotherapy. Cancer. 2005;103:339–348. Spiller SE, Hawkins DS, Finn LS, Sze RW, Sybert V. Metastatic malignant melanoma presenting as pancytopenia in a three-year-old boy: a case report, Pediatric Blood and Cancer. 2005;45:60–63. Stirewalt DL, Kopecky KJ, Meshinchi S, Engel JH, Pogosova-Agadjanyan EL, Linsley J, Slovak ML, Willman CL, Radich JP. Size of FLT3 internal tandem duplication has prognostic signiп¬Ѓcance in patients with acute myeloid leukemia. Blood. Dec 20, 2005; e-publication. Stapleton FB, Pendergrass TW. Improving departmental faculty meetings: an analysis of one department’s approach. J Pediatrics. 2005;146:155–156. Vakoc CR, Letting DL, Gheldof N, Sawado T, Bender MA, Groudine M, Weiss MJ, Dekker J, Blobel GA. Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1. Molecular Cell. 2005;17:453–462. Walter RB, Raden BW, Kamikura DM, Cooper JA, Bernstein ID. Influence of CD33 expressing levels and ITIM-dependent internalization on gemtuzumab ozogamicin-induced cytotoxicity. Blood. 2005;105(3):1295–1302. Wenhong F, Pritchard JI, Olson JM, Khalid N, Zhao LP. A class of models for analyzing GeneChipВ® gene expression analysis array data. BMC Genomics. 2005;6:16. Zanis-Neto J, Flowers MED, Medeiros CR, Bitencourt MA, Bonп¬Ѓm CM, SetГєbal DC, Funke V, Sanders JE, Deeg HJ, Kiem HP, Martin P, Leisenring W, Storb R, Pasquini R. Low-dose cyclophosphamide conditioning for haematopoietic cell transplantation from HLA-matched related donors in patients with Fanconi anaemia. Br J Haematol. 2005;130:99–106. 136 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Hospitalists The Division of Hospital Medicine (in the Department of Pediatrics) consists of pediatricians who serve as attending physicians for inpatients at Seattle Children’s Hospital. Division physicians attend on patients whose primary care physicians prefer a hospital-based physician. Our physicians ensure that the medical team keeps in close contact with primary care physicians to coordinate inpatient and outpatient care. We provide care using a family-centered model and meet daily with parents, nurses and resident physicians to develop a plan of care and update families on the child’s condition. As hospitalists with particular expertise in caring for pediatric inpatients, division members also take a lead role in treating patients with complex medical needs, and in quality improvement projects on the inpatient medical service. Division physicians also participate extensively in medical education, providing formal lectures, bedside teaching and mentoring for medical students and resident physicians. TEACHING, RESEARCH AND CLINICAL EXPERTISE Glen S. Tamura, MD, PhD, is director of the inpatient medical service at Seattle Children’s Hospital and assistant professor in the Department of Pediatrics at the University of Washington School of Medicine. Dr. Tamura received his MD and PhD from Stanford University, and trained in pediatrics and pediatric infectious diseases at the University of Washington. His clinical interests are focused on general inpatient pediatric medicine and infectious diseases. He is assistant director of the Pediatric Infectious Diseases Fellowship Program. He teaches clinical skills to second-year medical students, and mentors approximately 40 students throughout their medical school career. Dr. Tamura’s research interests include clinical research into quality improvement and patientcentered care, and basic science research in the pathogenesis of Group B Streptococcal infections. FACULTY Glen S. Tamura MD, PhD, Director Glen S. Tamura, MD, PhD, Director Julianne K.J. Bishop, MD Tellen Bennett, MD Ronald L. Dick, MD Janie G. Hallstrand, MD Kristin Hayward, MD Darren Migita, MD Anne E. Phalen, MD Joel S. Tieder, MD Julianne K.J. Bishop, MD, is attending physician on the inpatient ward at Seattle Children’s Hospital and clinical instructor in the Department of Pediatrics at the University of Washington School of Medicine. She completed her residency in pediatrics at Seattle Children’s. Dr. Bishop earned her MD from the University of Kansas. She is a Fellow of the American Academy of Pediatrics. Dr. Bishop’s clinical interests include ethics and palliative care. Tellen Bennett, MD, is attending physician at Seattle Children’s Hospital and clinical instructor in the Department of Pediatrics in the University of Washington School of Medicine and a member of the Emergency Department Clinical Faculty. He earned his MD from the Johns Hopkins School of Medicine and completed a pediatrics residency at the University of Washington. He also attends on the pediatric inpatient service of Evergreen Community Hospital and in the Emergency Department at Seattle Children’s. He is a Pediatric Advanced Life Support Instructor and is active in the resident mock code training program. His research interests include mechanisms of injury in trauma, outcomes improvement through critical care education and the application of computer technology to training for high acuity, low frequency events. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 137 Hospitalists Ronald L. Dick, MD, is attending physician at Seattle Children’s Hospital and clinical assistant professor of pediatrics at the University of Washington School of Medicine. Dr. Dick earned his MD from the University of Massachusetts Medical School and completed his pediatrics residency at the University of Washington. He worked at The Everett Clinic in Everett, Wash., where he started the inpatient pediatric hospitalist service. He served as medical director for the Pediatrics Services Program at Providence Everett Medical Center. In addition to caring for general medicine patients, Dr. Dick focuses on the care of medically complex children with prolonged hospital stays. He is involved in resident and medical student education through bedside and didactic teaching. He is interested in quality improvement, especially in issues related to the care of medically complex children, and is a member of the Quality Improvement Steering Committee. Janie G. Hallstrand, MD, is attending physician at Seattle Children’s Hospital and clinical associate professor of pediatrics at the University of Washington School of Medicine. She also works with medically complex children with prolonged hospital stays. She earned her MD at the University of Vermont School of Medicine and completed residency training at Maine Medical Center. Dr. Hallstrand is involved with resident and medical student education through bedside and didactic teaching. She is interested in quality improvement and participates in rapid process improvement. Kristen Hayward, MD, is attending physician at Seattle Children’s Hospital. She is a member of the clinical faculty in the Department of Emergency Medicine and an auxiliary faculty member of the University of Washington School of Medicine. Dr. Hayward received her MD at the University of California, San Francisco and completed a pediatrics residency at the University of Washington. Dr. Hayward is responsible for the initial assessment, laboratory evaluation and treatment of children seen in the emergency room and those hospitalized for ongoing therapy. She supervises pediatric family medicine residents and medical students involved in patient care at Seattle Children’s, and she provides teaching in daily rounds and longer discussions of patient-related topics. Her areas of clinical interest include autoimmunity and musculoskeletal problems in children. She has an interest in ongoing trainee development, speciп¬Ѓcally in teaching educational skills to residents. 138 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Darren Migita, MD, is pediatric hospitalist at Seattle Children’s Hospital and assistant clinical professor in pediatrics at the University of Washington School of Medicine. He is also chief of the pediatric hospitalist section at Evergreen Hospital Medical Center in Kirkland, Wash,, a Seattle Children’s–sponsored program founded in 1999. He completed his pediatrics residency at Seattle Children’s. Dr. Migita has been involved in a variety of Rapid Process Improvement Workshops in conjunction with Seattle Children’s hospitalwide Continuous Performance Improvement (CPI) initiative. Project themes have included: improving the inpatient experience for families and providers, maximizing pediatric inpatient and ED throughput efп¬Ѓciency, streamlining the direct admission process for community physicians and standardizing the care of pediatric inpatients through the use of evidencebased clinical guidelines. He was also instrumental in creating a single-care-provider hospitalist service (aka the Relief Attending Service) at Seattle Children’s. Dr. Migita’s current focus is the creation of a hospitalwide vascular access service to streamline the availability of central lines and decrease bloodstream infection rates. With Dr. Dimitri Christakis, he co-authored a pediatric handbook, The Saint Frances Guide to Pediatrics. Anne E. Phalen, MD, is attending physician at Seattle Children’s Hospital. She is also clinical associate professor of pediatrics at the University of Washington School of Medicine. She received her MD from Georgetown University Medical School and completed her residency at the Children’s Hospital National Medical Center in Washington, D.C. Dr. Phalen works with medically complex children having prolonged medical stays. She also provides didactic and bedside teaching for residents and medical students on the wards. Her interests also include patient care quality improvement projects. Joel S. Tieder, MD, is pediatric hospitalist and clinical instructor at Seattle Children’s Hospital’s hospitalist program at Evergreen Hospital Medical Center in Kirkland, Wash., and for the Department of Pediatrics at the University of Washington School of Medicine. At Seattle Children’s he serves as an attending on the inpatient pediatric service, relief attending service and medically complex care service, where he provides specialized care for hospitalized children and serves as an educator for residents and medical students. He is enrolled in the University of Washington School Hospitalists of Public Health MPH program in epidemiology. He serves on Seattle Children’s Inpatient Guideline Committee and is developing acute gastroenteritis guidelines that facilitate quality of care and patient safety assessment. He is an active member of the American Academy of Pediatrics Section of Hospital Medicine. Visiting professorship, Yakima/Toppenish, Wash., June 1–2, 2005 The Effect of a Standardized Rounding Practice on Patient Satisfaction, 2005 NACHRI annual meeting poster presentation, October 11, 2005 AWARDS AND HONORS Darren Migita, MD Poster winner, 2005 NACHRI annual meeting, Palm Springs, Calif., October 2005 Glen S. Tamura, MD, PhD Poster winner, 2005 NACHRI annual meeting, Palm Springs, Calif., October 2005 TEACHING AND PRESENTATIONS Tellen Bennett, MD Status Epilepticus, PALS curriculum, June 2005 Kristen Hayward, MD Medical student orientation to pediatric physical exam, Seattle Children’s, April 2005 Pediatric Capstone cases, University of Washington, May 2005 Glen S. Tamura, MD, PhD Responding to Parental Concerns About Vaccines, Seattle Children’s, February 4, 2006 Update on Infectious Diseases, Seattle Children’s, February 4, 2006 Vaccine Update, Sacred Heart Hospital, Spokane, Wash., March 17, 2005 Responding to Parental Concerns About Vaccines, Sacred Heart Hospital, Spokane, Wash., March 17, 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 139 Infectious Disease, Immunology and Rheumatology The Division of Infectious Disease, Immunology and Rheumatology comprises three sections in the Department of Pediatrics (see separate entries for the Immunology Clinical Program and the Section of Rheumatology). The division offers consultation and diagnostic services in the management of suspected or proven infectious diseases in children, in the hospital and the outpatient setting. We treat complicated, chronic and recurrent infections that arise from exposure to infectious diseases, or that follow organ or hematopoietic cell transplantation and other surgical procedures. The division provides laboratory assistance in the diagnosis of infections and assistance in the selection and dosage of antibiotics, antivirals and other forms of therapy. The Virology Clinic provides specialized treatment for difficult viral infections such as herpes and for patients who have been exposed to or diagnosed with HIV or AIDS. Our program works with Seattle Children’s home services to support patients on home IV antimicrobial therapy. Our physicians provide one of the largest telephone information consultation services for the hospital, serving community physicians in the WAMI region (Washington, Alaska, Montana, Idaho). International travel advice is available, providing the education and immunization of people traveling to foreign countries and the treatment of patients returning from a foreign country with symptoms of infection. Our research program investigates the specific traits of microbes that infect humans and influence the ability of the microbe to establish infection in the host. We also investigate the immune mechanisms that thwart infection by human pathogens. These studies include basic science experimentation at the molecular and cellular level and the use of relevant animal models of human infections. Clinical studies investigate how viruses cause disease in childhood and in children with immune-related problems from chemotherapy or transplantation. We also investigate new drugs and new vaccines for treating infections. TEACHING, RESEARCH AND CLINICAL EXPERTISE Craig E. Rubens, MD, PhD, is chief of the Division of Infectious Disease, Immunology and Rheumatology at Seattle Children’s Hospital and the division in the pediatrics department at the University of Washington School of Medicine. He is adjunct professor of microbiology and holds the Children’s Hospital Guild Association Endowed Chair in Pediatric Infectious Disease Research. He is program director for the Pediatric ID Training Program. He completed his MD, his pediatrics residency and his pediatric infectious disease subspecialty certification at the University of Washington. Dr. Rubens is investigating the important biologic mechanisms involved in bacterial pneumonia, and his work has identified important virulence traits of bacteria that are critical to interaction with the host and for escaping innate immunity. His laboratory has also identified the genetic and biosynthetic basis for production of these virulent factors. Dr. Rubens was an integral part of development of the 307 Westlake 140 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Research Center. His society memberships include the American Society of Clinical Investigation and the American Pediatric Society, and he has served as consultant and grant reviewer for the FDA and the NIH/ NIAID. He is involved in graduate student education and training and has served on several university committees to improve faculty and graduate education. Dr. Rubens is also a Regional Affiliate Investigator for the Center on Human Development and Disability. Jane L. Burns, MD, is director of the Infectious Disease Clinic at Seattle Children’s Hospital and professor in the Department of Pediatrics at the University of Washington School of Medicine. Dr. Burns trained in pediatrics and pediatric infectious diseases at the University of Washington. She directs the Therapeutics Development Network Core Laboratory for Cystic Fibrosis Microbiology. Her clinical interests include the management of recurrent fevers, bone and joint infections, mycobacterial lymphadenopathy and urinary tract infections. Dr. Burns has been active Infectious Disease, Immunology and Rheumatology for many years on the Pharmacy and Therapeutics Committee at Seattle Children’s and has had a longstanding clinical and research interest in antimicrobial resistance. Her research is both translational and basic in the areas of antibiotic resistance and cystic fibrosis microbiology. Dr. Burns has been active in many regional and national microbiology and infectious disease societies and is a founding member of the International Burkholderia Cepacia Working Group. Janet A. Englund, MD, is attending physician at Seattle Children’s Hospital, associate professor of pediatrics at the University of Washington and clinical associate at Fred Hutchinson Cancer Research Center (FHCRC). She serves as the infectious disease representative with the Seattle Cancer Care Alliance. She serves as chair of the Pharmacy and Therapeutics Committee at Seattle Children’s Hospital, and as pediatric representative of the infectious disease program at FHCRC. Her clinical interests include the diagnosis, prevention and treatment of respiratory diseases in children and immunocompromised patients. Dr. Englund’s research involves the study of live and inactivated influenza vaccines in pediatric populations, including infants, toddlers, school-age children and immunocompromised patients, and the evaluation of molecular-based methods for the diagnosis of new and emerging respiratory virus pathogens in these populations. She also conducts clinical trials for other vaccine-preventable diseases, including pertussis (whooping cough) and has interests in the field of maternal immunization. Her ongoing research involves the study of respiratory syncytial virus (RSV), human metapneumovirus, and human coronaviruses in children attending day care, and as outpatients and inpatients. Dr. Englund has conducted clinical studies with the assistance of practicing pediatricians around Washington. FACULTY Craig E. Rubens MD, PhD, Chief Craig E. Rubens, MD, PhD, Chief Jane L. Burns, MD Janet A. Englund, MD Lisa M. Frenkel, MD Soren M. Gantt, MD, PhD Tina Guina, PhD Amanda L. Jones, PhD Tobias R. Kollmann, MD, PhD Ann J. Melvin, MD, MPH Tamara C. Pozos, MD, PhD Lisa M. Frenkel, MD, is attending physician at Seattle Children’s Hospital and professor in the Department of Pediatrics at the University of Washington School of Medicine. Dr. Frenkel trained in pediatrics and pediatric infectious diseases at the University of California, Los Angles and the University of Rochester in New York. She is the director of the HIV program at Seattle Children’s. She has studied herpes simplex virus (HSV) and human immunodeficiency virus type 1 (HIV-1), and has led and participated in multicenter international trials. Her studies have found that antiviral drugs can prevent most HIV-1 transmissions from mothers to their babies, have improved the treatment of HIV-1 infected children and have elucidated the role of drug-resistant virus in HIV-1 disease progression. Dr. Frenkel’s laboratory focuses on the development and transfer of practical and economical assays for early HIV-1 diagnosis and monitoring of drug-resistant mutants in resource-strapped communities; it also serves as a developmental laboratory for the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network. Dr. Frenkel directs research projects aimed at understanding the evolution and treatment of drug-resistant viruses in children and adults with colleagues in India, Mozambique, Peru, Thailand, the US and Zimbabwe. Soren M. Gantt, MD, PhD, is attending physician at Seattle Children’s Hospital and acting assistant professor at the University of Washington School of Medicine. He earned a combined MD-PhD at New York University School of Medicine. He completed his pediatrics residency and a fellowship in infectious diseases at Seattle Children’s. Dr. Gantt has developed projects focused on mother-to-child transmission of HIV-1 through breastfeeding in Zimbabwe and Mozambique. Dr. Gantt was accepted to the K12 Clinical Research Career Development Program and attends the University of Lakshmi Rajagopal, PhD Sherilyn Smith, MD Washington School of Glen S. Tamura, MD, PhD Public Health. Kevin B. Urdahl, MD, PhD Sing Sing Y. Way, MD, PhD Scott J. Weissman, MD Danielle M. Zerr, MD, MPH SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 141 Infectious Disease, Immunology and Rheumatology Tina Guina, PhD, is research assistant professor in the Department of Pediatrics, Division of Infectious Diseases and principal investigator of WAMI Research Center for Excellence (RCE) in biodefense and emerging infectious diseases. Her research interests include studies of Gram-negative bacterial respiratory infections such as chronic infections of cystic fibrosis (CF) patient airways with Pseudomonas aeruginosa, and severe acute infections caused by Francisella tularensis and Yersinia pestis. Dr. Guina is using large-scale genomic and postgenomic technologies for the identification of novel F. tularensis virulence factors and P. aeruginosa protein markers that are associated with the development of chronic and severe airway infections in CF patients. Amanda L. Jones, PhD, is research assistant professor in the Department of Pediatrics at the University of Washington School of Medicine and adjunct research assistant professor in the Pathobiology Department at the University of Washington School of Public Health. Dr. Jones was senior fellow and then research scientist in the Division of Infectious Diseases at Seattle Children’s Hospital. She earned her PhD in microbial pathogenesis from the University of Calgary in Canada. Research in her laboratory focuses on immune evasion strategies used by group B streptococcus and the molecular pathogenesis of neonatal infections. Dr. Jones regularly teaches classes in medical bacteriology and on critical thinking and research design at the University of Washington schools of Medicine and Public Health. She is principal investigator on an NIH-funded research grant. Tobias R. Kollmann, MD, PhD, is affiliate assistant professor at Seattle Children’s Hospital. He received his MD from Albert Einstein College of Medicine in the Bronx, NY. He completed residency training in pediatrics and a fellowship in pediatric infectious diseases at the University of Washington School of Medicine. He also served as a consultant to the Immunization Safety Review Committee of the American Institute of Medicine (IOM). His research focused on the neonatal immune system, and he was the first to describe a key defect that might be responsible for increased infections and decreased vaccine response observed in neonates. He subsequently designed ways to circumvent this defect using an attenuated strain of Listeria monocytogenes as a vaccine vehicle and is working on clinical application for the Listeria-based 142 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON vaccine platform. This yet unpublished work has been recognized by the award of an NIH-KO8, a Children’s Health Research Center Grant and a Puget Sound Partners for Global Health/Gates Foundation grant. Ann J. Melvin, MD, MPH, is co-director of the HIV program at Seattle Children’s Hospital and associate professor of pediatrics at the University of Washington School of Medicine. At Harborview Medical Center she is director of the Northwest Family Center Pediatric Clinic and the teen and young adult HIV program. She completed an internship in pediatrics at the University of California, San Francisco; she completed a pediatrics residency and a fellowship in pediatric infectious disease at Seattle Children’s. Dr. Melvin’s research interests are in the antiretroviral management of HIV disease in children and prevention and management of complications of HIV treatment. Dr. Melvin is a principal investigator in the Pediatric AIDS Clinical Trials Group unit at the University of Washington, through which she is co-chair of several national and international research trials. She is also director of the Research Subjects Advocate Program of the Pediatric Clinical Research Center of the University of Washington. Tamara C. Pozos, MD, PhD, is attending physician at Seattle Children’s Hospital and acting instructor in the Department of Pediatrics at the University of Washington School of Medicine. She earned a combined MD-PhD at Stanford University. She completed a pediatrics residency at the University of California, San Francisco and a fellowship in pediatric infectious diseases at Seattle Children’s Hospital. Dr. Pozos’ research goal is to understand innate immune responses to mycobacterial infection by investigating the interconnected roles of immune cell migrations, matrix metalloproteinase activity and early granuloma formation. Her clinical and teaching interests are pediatric tuberculosis and other infections in children of the developing world, particularly Latin America. Dr. Pozos mentors and encourages trainees, particularly women and minorities, to consider careers in academic medicine. Lakshmi Rajagopal, PhD, is research assistant professor in the departments of Pediatrics and Microbiology at the University of Washington School of Medicine. She earned her PhD from the Jawaharlal Nehru University in India and completed a fellowship in Infectious Disease, Immunology and Rheumatology the Department of Pediatrics at the University of Washington. Dr. Rajagopal’s research interests center on the role of eukaryotic-type signaling in prokaryotic organisms. Her research focuses on elucidating the role of a eukaryotic-type serine/threonine kinase in the human neonatal pathogen, Group B Streptococci. A number of peer-reviewed articles have resulted from her research. Dr. Rajagopal was recently awarded a Pilot Children’s Hospital and Regional Medical Center Steering Committee Award to establish the link between eukaryotic-type and two-component signaling in regulation of a GBS toxin, beta-hemolysin. Sherilyn Smith, MD, is co-director of the Infectious Disease Clinic and an attending physician at Seattle Children’s Hospital and associate professor of pediatrics at the University of Washington School of Medicine. She completed residency training in pediatrics and served as chief resident at the University of California, San Diego. She completed a fellowship in pediatric infectious diseases at the University of Washington. Her clinical responsibilities include the Infectious Disease Clinic, inpatient infectious disease consult service and general pediatrics ward service. She is also associate director of the Pediatric Clerkship at Seattle Children’s and head of the Big Sky College at the University of Washington School of Medicine. Dr. Smith is on the editorial board for CLIPP (Computerized Learning in Pediatrics Project), a national computerized curriculum of pediatric cases for medical students. Glen S. Tamura, MD, PhD, is director of the inpatient medical service at Seattle Children’s Hospital and assistant professor in the Department of Pediatrics at the University of Washington School of Medicine. Dr. Tamura received his MD and PhD from Stanford University, and trained in pediatrics and pediatric infectious diseases at the University of Washington. His clinical interests are focused on general inpatient pediatric medicine and infectious diseases. He is assistant director of the Pediatric Infectious Diseases Fellowship Program. He teaches clinical skills to second-year medical students, and mentors approximately 40 students throughout their medical school career. Dr. Tamura’s research interests include clinical research into quality improvement and patient-centered care, and basic science research in the pathogenesis of Group B Streptococcal infections. Kevin B. Urdahl, MD, PhD, is assistant professor of pediatrics at the University of Washington School of Medicine. His clinical interests include the diagnosis and management of infants, children and adolescents with infectious diseases, particularly tuberculosis and diseases associated with robust immune cell activation (e.g., Kawasaki’s Disease and Toxic Shock Syndrome). His research focuses on elucidating the mechanisms of protective immunity to tuberculosis by applying tools of modern immunology in the mouse model. Dr. Urdahl’s laboratory showed that a subset of suppressive T cells (i.e., T regulatory cells that normally function to suppress immune responses to self-antigens and prevent autoimmunity) is activated after aerosol infection with Mycobacterium tuberculosis, dampens protective immunity against the organism and helps facilitate its persistence. His goal is to test the idea that vaccines that induce large numbers of M. tuberculosis–specific T cells producing IFN-Гђ, but induce little or no M. tuberculosis–specific T regulatory cells, will have the greatest protective efficacy. Dr. Urdahl is the recipient of a Burroughs Wellcome Fund Career Award in the Biological Sciences. Sing Sing Y. Way, MD, PhD, is attending physician at Seattle Children’s Hospital and acting assistant professor in the Department of Pediatrics at the University of Washington School of Medicine. Dr. Way cares for patients with infectious disease and general pediatric medical problems. His research interests encompass using infectious disease models to examine how protective immune responses are generated, with the ultimate goal of more rational vaccine design. Dr. Way has published numerous manuscripts over the past ten years examining the immune response to Shigella flexneri and Listeria monocytogenes infections. He has received the Infectious Disease Society Young Investigator Award for vaccine research. Scott Weissman, MD, is attending physician at Seattle Children’s Hospital and acting instructor in the Department of Pediatrics at the University of Washington School of Medicine. He earned his MD from the University of California, Irvine College of Medicine. He completed a pediatrics residency at Kaiser Foundation Hospital, Los Angeles, and completed a fellowship in pediatric infectious disease at Seattle Children’s. His research concerns the evolution of virulence properties in Escherichia SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 143 Infectious Disease, Immunology and Rheumatology coli strains associated with newborn meningitis and urinary tract infection. Specifically, the work focuses on the study of allelic variation in fimbrial adhesin genes to delineate fine phylogenetic relationships between strains grouped together by conventional molecular footprinting techniques such as multiple locus sequence typing. This improved resolution allows the identification of key genetic adaptations, including point mutation, recombination and pathogenicity island acquisition/deletion that promote adaptation to novel niches. Fimbrial adhesin sequence typing (FAST) should provide an important tool in the understanding of genomic plasticity in E. coli evolution, with application in bacterial pathogenesis, population biology and epidemiology. This work has been published and presented at national conferences. Dr. Weissman’s clinical interests include the treatment of recurrent urinary tract infections, as well as infections of skin/ soft tissue and bone by Staph aureus. Danielle M. Zerr, MD, MPH, is medical director of infection control at Seattle Children’s Hospital, assistant professor in the Department of Pediatrics at the University of Washington School of Medicine and affiliate investigator at the Fred Hutchinson Cancer Research Center. Dr. Zerr’s research has focused on the epidemiology of human herpes virus 6 (HHV-6) infections in healthy children and immunocompromised hosts. Dr. Zerr is principal investigator on a study of HHV-6 reactivation in hematopoietic stemcell transplant recipients. She is also interested in the epidemiology, viral pathogens and prognosis of nonfebrile seizures occurring in the setting of mild illness as well as the epidemiology and prevention of infections associated with health care. AWARDS AND HONORS Tobias R. Kollmann, MD, PhD Burroughs Wellcome Career Award in the Biomedical Sciences, 2005 Tamara C. Pozos, MD, PhD Award for poster presented, Department of Immunology retreat, 2005 Award for talk, fellows research competition, Seattle Children’s, 2005 144 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Craig E. Rubens, MD, PhD Children’s Hospital Guild Endowed Chair in Pediatric Infectious Disease Research, awarded 2005 Sherilyn Smith, MD Outstanding Clinical Teacher Award, University of Washington, 2005 Margaret S. Anderson Award, University of Washington, 2005 Sing Sing Y. Way, MD, PhD Child Health and Research Center Scholar, University of Washington, 2005 RESEARCH FUNDING New Jane L. Burns, MD A Pilot Study of Inhaled Nitric Oxide in the Treatment of High-Density Respiratory Tract Bacterial Load in Adults with Cystic Fibrosis, Sensor Medics Corporation, $84,033 Janet A. Englund, MD Evaluation of Serologic Responses to Fluzone in Infants >6 Month of Age Who Did or Did Not Receive Fluzone Vaccine at 2 Months of Age, Sanofi Pasteur Inc., $93,903 The Impact of Respiratory Viruses in Infants in Fulltime Daycare, MedImmune, Inc., $78,575 A Phase IV Study to Evaluate the Effectiveness of Flumist Vaccination in a School-Based Intervention Program, University of Washington, MedImmune, Inc., $53,219 Proof of Concept Study of the Safety and Immunogenicity of Influenza Virus Vaccine Fluzone* 2004–05 Among Healthy Children 2 Months vs. 6 months of Age, Aventis Pharmaceuticals, $204,600 Role of Viruses in CF Airway Infections, Cystic Fibrosis Foundation, $82,844 Infectious Disease, Immunology and Rheumatology Safety and Immunogenicity of Fluzone Influenza Virus Vaccine (2005-2006 Formulation) Among Healthy Children 6 to 12 Weeks of Age, GRC28, Sanofi Pasteur Inc., $101,999 Lisa M. Frenkel, MD Etiology of mastitis in HIV-1 infected women, National Institute of Allergy and Infectious Diseases/NIH/ DHHS, $225,000 Reservoirs of Drug-Resistant HIV-1, National Institute of Allergy and Infectious Diseases/NIH/DHHS, $316,171 Tina Guina, PhD Bac Act-Proj 3, Yr 03, Sam Miller/NIAID/NIH, $173,632 New Opp-Vacc Dev-Sub, Sam Miller/NIAID/NIH, $82,671 Proteomics Core, Sam Miller/NIH, $50,000 Continuing Jane L. Burns, MD Effects of Azithromycin on P. aeruginosa Gene Expression, National Institute of Allergy and Infectious Diseases/NIH/DHHS, $77,500 Standard vs. Biofilm Susceptibility Testing in Cystic Fibrosis, Cystic Fibrosis Foundation, $228,355 Therapeutics Development Center Microbiology Core, Cystic Fibrosis Foundation, $223,762 Lisa M. Frenkel, MD Women’s HIV Pathogenesis Program, University of Washington, National Institute of Child Health and Human Development/NIH/DHHS, $85,787 Immunization by HIV Exposure During Chemoprophylaxis, National Institute of Child Health and Human Development/NIH/DHHS, $324,912 PACTG.25.P1015.01, Social & Scientific Systems, National Institute of Allergy and Infectious Diseases/ NIH/DHHS, $68,428 Pediatric HIV Clinical Trials Network, Westat Inc., National Institute of Child Health and Human Development/NIH/DHHS, $892,630 Antiretroviral Drug Resistance Testing, Seattle–King County Department of Public Health, National Center for HIV Prevention of the Centers for Disease Control and Prevention, $140,672 Amanda L. Jones, PhD Role of Penicillin Binding Protein 1a in GBS Virulence, National Institute of Allergy and Infectious Diseases/ NIH/DHHS, $335,250 Craig E. Rubens, MD, PhD Academic Pediatric Infectious Disease (Competing Continuation), National Institute of Allergy and Infectious Diseases/NIH/DHHS, $272,435 Early Host: Microbial Interactions in S. Aureus Pneumonia, University of Washington, National Heart, Lung and Blood Institute, $173,676 Genetics of Virulence of Type III Group B Streptococcus, National Institute of Allergy and Infectious Diseases/ NIH/DHHS, $242,281 Iron Acquisition by Group B Streptococcus: The Role of Iron Transport, March of Dimes, $88,301 Role of a Novel Signal Transduction Pathway in GBS, National Institute of Allergy and Infectious Diseases/ NIH/DHHS, $303,950 Kevin B. Urdahl MD, PhD The Role of MHC Class I Molecules in Immunity Against Mycobacterium Tuberculosis, Burroughs Welcome Foundation, $500,000 MHC Class 1 Molecules in Immunity Against Tuberculosis, NIAID/NIH, $120,663 Scott J. Weissman, MD Type 1 Fimbrial Variation in E. coli 018:K1:H7 Virulence, National Institute of Allergy and Infectious Diseases/NIH/DHHS, $109,620 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 145 Infectious Disease, Immunology and Rheumatology Danielle Zerr, MD, MPH Defining Primary HHV-6 and HHV-7 Infections in Children, National Institute of Allergy and Infectious Diseases/NIH/DHHS, $158,220 HHV-6 and CNS Disease Following Stem Cell Transplant, National Institute of Allergy and Infectious Diseases/NIH/DHHS, $318,426 TEACHING AND PRESENTATIONS Quantitative RSV RT-PCR in Hospitalized Children, International RSV Symposium, Oxford, England, September 17–19, 2005 New Vaccines: Influenza Vaccination for All, Alaska Health Summit, Anchorage, Alaska, November 27–29, 2005 Jane L. Burns, MD Microbiology Results from a Phase 2 Clinical Study of Aztreonam Lysinate for Inhalation: A New Inhaled Antibiotic to Treat CF Patients with Pseudomonas aeruginosa, 28th European Cystic Fibrosis Conference, Crete, Greece, 2005 What’s New with Pertussis, Grand Rounds, Alaska Native Medical Center, Anchorage, Alaska, November, 28, 2005 Hypermutability in CF Pathogens and The Role of the Clinical Microbiology Laboratory (roundtable moderator), North American Cystic Fibrosis Conference (NACFC), Baltimore, 2005 Lisa M. Frenkel, MD Laboratory Quality Assurance and Capacity Building for HIV Research, University of Zimbabwe, Harare, Zimbabwe, February 7–9, 2005 Pathophysiology and Therapy of Cystic Fibrosis and Approaches to Antimicrobial Therapy in CF, Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, DC, 2005 Invited speaker. 3rd Annual Western Regional International Health Conference, University of Washington, February 2005 Antibiotic Resistance and Its Impact on the Management of Neonatal Infections, Neonatal Pharmacology Conference, Seattle, 2005 Janet A. Englund, MD Influenza, Maternal Immunization, Sexually Transmitted Diseases, Neonatal Infections, annual convention of the Pediatric Infectious Disease Society of the Philippines, Manila, Philippines, February 23–25, 2005 Update on Vaccines, Grand Rounds, St. Peter’s Hospital, Olympia, Wash., March 17, 2005 Pandemic Influenza Preparedness, Antiviral Subcommittee, sponsored by NVAC, Washington, D.C., April 19–20, 2005 146 Maternal Immunization, sixth advanced vaccinology course co-sponsored by Fondation Merieux/NIH/ WHO/CDC, Annecy, France, June 1–4, 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON International Pertussis Consensus Symposium, Paris, France, Dec. 11, 2005 Invited speaker, 2nd Workshop on HIV persistence, St. Martin, French West Indies, 2005 Ann J. Melvin, MD, MPH Congenital CMV: Etiology and Risk Factors for Childhood Hearing Loss, lecture to audiologists, University of Washington, August 2005 Tamara C. Pozos, MD, PhD Research presented at US-Japan Conference on Tuberculosis and Leprosy, Seattle, August 2005 Craig E. Rubens, MD, PhD Starting and Maintaining a Successful Research Program, St. Jude/PIDS Pediatric Microbial Research Conference, Memphis, Tenn., February 2005 Role of a Eukaryotic-Type Signal Transduction Pathway in Streptococcus agalactiae, 8th Bay Area Symposium on Microbial Pathogenesis, San Francisco, March 2005 Infectious Disease, Immunology and Rheumatology Regulation of Purine Biosynthesis by a EukaryoticType Kinase in Group B Streptococci Contributes to Bacterial Survival During Infection, Current Global Perspectives in the Field of Streptococcal and Pneumococcal Infections, London, April 2005 Bacterial Gene Expression During the Early Stages of S. aureus pneumonia in a Mouse Model, 105th ASM general meeting, Atlanta, June 2005 Group B Streptococcus: Update on Prevention and Pathogenesis, Grand Rounds, University of Washington, February 2005 Sherilyn Smith, MD Infectious Disease Update: New Antibiotics, Superinfections and Resistance, Nursing Care of the Hospitalized Child, Seattle, April 2005 Glen S. Tamura, MD, PhD Vaccine Update and Responding to Parental Concerns About Vaccines, Sacred Heart Hospital, Spokane, Wash. March 17, 2005 Launching a Successful Academic Career, fellows workshop, Seattle Children’s, December 14, 2005 Diagnosis, Treatment and Prevention of Tuberculosis in Children: Limitations of Current Modalities and Possibilities for the Future, Grand Rounds, Seattle Children’s, December 2005 Scott J. Weissman, MD Advanced Bacterial Genetics Course, Cold Spring Harbor Laboratory, N.Y., June 8–27, 2005 Infectious Disease in the Field, paramedic training course, Harborview Medical Center, Seattle, 2005 Danielle M. Zerr, MD, MPH HHV-6, 7 and 8: From Cradle to Transplant Recipient, 45th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, D.C., December 2005 HHV-6 Associated CNS Dysfunction Following HSCT, neurology Grand Rounds, University of Washington, March 2005 Tick-Borne Diseases and New Trends in Antibiotic Resistance and Vaccine Controversies, visiting professorship Yakima/Toppenish, June 1–2, 2005 PUBLICATIONS Kevin B. Urdahl, MD, PhD The Role of MHC Class I Molecules in Immunity Against Tuberculosis, International Training and Research in Emerging Infectious Diseases, Intracellular Pathogens, New Delhi, India, 2005 Beckmann C, Brittnacher M, Ernst R, Mayer-Hamblett N, Miller SI, Burns JL. Use of phage display to identify potential Pseudomonas aeruginosa gene products relevant to early cystic fibrosis airway infections. Infect Immun. 2005;73:444–452. Vaccinations: Rationale, Adverse Reactions, Parental Concerns, fellow lecture, Seattle Children’s, October 28, 2005 Benson C, Gantt S, Xuan Q, Abe P, Zerr DM. Use of 16S rDNA polymerase chain reaction to identify Haemophilus influenzae Type b as the etiology of pericarditis in an infant [Letter/case report]. Pediatric Infect Dis. 2005;24(3):287–288. T Cells and TB: Lessons from the Mouse Model, Department of Pathobiology seminar, University of Washington. 2005 Foxp3-Expressing T Regulatory Cells in Tuberculosis; Foxp3-Expressing T Regulatory Cells Accumulate in the Lungs after Aerosol Infection and Suppress Immunity to Mycobacterium Tuberculosis and Basic Immunology Considerations for TB/Leprosy Product Development (panel workshop), 40th Annual U.S.-Japan Cooperative Medical Science Program Tuberculosis and Leprosy Conference, Seattle, 2005 Cieslewicz MJ, Chaffin D, Glusman G, Kasper D, Madan A, Rodrigues S, Fahey J, Wessels MR, Rubens CE. Structural and genetic diversity of group B Streptococcus capsular polysaccharides. Infect Immun. 2005;73:3096–3103. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 147 Infectious Disease, Immunology and Rheumatology Chaffin DO, Mentele LM, Rubens CE. Sialylation of group B streptococcal capsular polysaccharide is mediated by cpsK and is required for optimal capsule polymerization and expression. Journal of Bacteriology. 2005;187:4615–4626. Li CC, Beck IA, Seidel KD, Coombs RW, Frenkel LM. Detection and quantification of HIV-1 p24Ag in dried whole blood and plasma on filter paper stored under various conditions. Journal of Clinical Microbiology. 2005;43:3901–3905. Christakis DA, Cowan CA, Garrison MM, Molteni R, Marcuse E, Zerr DM. Variation in inpatient diagnostic testing and management of bronchiolitis. Pediatrics. 2005;115:878–884. Moskowitz SM, Foster JM, Emerson JC, Gibson RL, Burns JL. Use of Pseudomonas biofilm susceptibilities to assign simulated antibiotic regimens for cystic fibrosis airway infection. Journal of Antimicrobial Chemotherapy. 2005;56:879–886. Englund JA, Walter EB, Fairchok MA, Monto AS, Neuzil KM. A comparison of two influenza vaccine schedules in 6–23 month old children. Pediatrics. 2005;115:1039–1047. Englund JA. In search of a vaccine for respiratory syncytial virus: the saga continues. Editorial, J Infect Dis. 2005;191:1036–1039. Fall LH, Berman NB, Smith S, White CB, Woodhead JC, Olson AL. Computer-assisted learning in pediatrics project (CLIPP): Multi-institutional development and utilization of a computer-assisted learning program for the core pediatric clerkship. Acad Med. 2005;80:847–855. Frenkel LM. Challenges in the diagnosis and management of neonatal herpes simplex virus encephalitis (solicited editorial). Pediatrics. 2005;115:795–797. Goldstein E, MacLaren C, Smith S, Mengert T, Maestas R, Foy H, Wenrich M, Ramsey PG. Promoting fundamental clinical skills in medical education using a competency-based small college approach. Acad Med. 2005;80:423–433. Johnson DC, McKarland EJ, Muresan P, Fenton T, McNamara J, Read JS, Hawkins E, Bouquin PL, Estep SG, Tomaras GD, Vincent CA, Rathore M, Melvin AJ, Gurunathan S, Lambert J. Safety and immunogenicity of an HIV-1 recombinant canarypox vaccine in newborns and infants of HIV-1-infected women. J Infect Dis. 2005;1992:2129–2133. Jones AL, Rubens CE. Molecular pathogenesis of group B streptococcal infections. In: Molecular Biology of Streptococci. Chhatwal S, ed. Wymondham, United Kingdom: Horizon Scientific Press, 2005. 148 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Nair BM, Joachimiak LA, Chattopadhyay S, Montano I, Burns JL. Conservation of a novel protein associated with an antibiotic efflux operon in Burkholderia cenocepacia. FEMS Microbiology Letters. 2005;245:337–344. Rajagopal L, Vo A, Silvestroni A, Rubens CE. Regulation of purine biosynthesis by a eukaryotictype kinase in Streptococcus agalactiae. Molecular Microbiology. 2005;56:1329–1346. Smith S, Melvin AJ. Normal development and physiology of the immune system. In: Handbook of Pediatric HIV Care 2nd ed. Zeicher S, Read J, eds. Lippincott, Williams & Wilkin, 2005. Tamura GS, Bratt DS, Yim HH, Nittayajarn A. Use of glnQ as a counterselectable marker for creation of allelic exchange mutations in group B Streptococci. App Environ Microbiol. 2005;71:587–590. Tan T, Halperin S, Cherry JD, Edwards K, Englund JA, Glezen P, Greenberg D, Rothstein E, Skowronski D. Pertussis immunization in the Global Pertussis Initiative North American region: recommended strategies and implementation considerations. Pediatr Infect Dis. 2005;24(Suppl);S83–S87. Tanabe H, Ayabe T, Bainbridge B, Guina T, Ernst RK, Darveau RP, Miller SI, Ouellette AJ. Mouse Paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria. Infect Immun. 2005;73:2312–2320. Infectious Disease, Immunology and Rheumatology Tettelin H, Masignani V, Cieslewicz MJ, Donati C, Medini D, Ward NL, Angiuoli SV, Crabtree J, Jones AL, Durkin AS, Rubens CE, et al. Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial “pan-genome.” Proceedings of the National Academy of Sciences USA. 2005;102:13950–13955. Tobin NH, Learn GH, Holte SE, Wang Y, Melvin AJ, McKernan JL, Pawluk DM, Mohan KM, Lewis PF, Mullins JI, Frenkel LM. Evidence that low-level viremias during effective HAART result from two processes: expression of archival virus and replication of virus. J Virol. 2005;79:9625–9634. Urdahl KB, Scott-Browne JP, Fontenot JD, Rudensky AY, Bevan MJ. FoxP3-expressing T regulatory cells accumulate in the lungs after aerosol infection and suppress immunity to Mycobacterium tuberculosis. Proceedings of the 40th US-Japan Cooperative Medical Science Program’s Tuberculosis and Leprosy Conference. July 27–30, 2005. Van Rie A, Wendelboe AM, Englund JA. Role of maternal pertussis antibodies in infants. Pediatric Infectious Disease Journal. 2005;24(Suppl):S62–S65. Way SS, Wilson CB. The Mycobacterium tuberculosis ESAT-6 homologue in Listeria monocytogenes is dispensable for growth in vitro and in vivo. Infect Immun. 2005;73:6151–6153. Wendelboe AM, Van Rie A, Salmaso S, Englund JA. Duration of immunity against pertussis after natural infection or vaccination. Pediatr Infect Dis. 2005;24(Suppl):S58–S61. Wu M, Guina T, Brittnacher M, Nguyen H, Eng J, Miller SI. The Pseudomonas aeruginosa proteome during anaerobic growth. J Bacteriol. 2005;187: 8185–8190. Zerr D, House N, Melvin AJ. Life-threatening viral disease and its treatment. In: Pediatric Critical Care, Mosby, 3rd Edition. Fuhrman BP, Zimmerman JJ, eds., 2005. Zerr DM. Alcohol hand rub: a simple solution in search of champions [Editorial]. Arch Pediatr Adolesc Med. 2005;159:502–503. Zerr DM. Effect of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation [Review]. Contagion. 2005;2:352–357. Zerr DM, Allpress AL, Heath J, Bornemann R, Bennett E. Decreasing hospital-associated rotavirus: a multidisciplinary hand hygiene campaign in a children’s hospital. Pediatr Infect Dis. 2005;24:397–403. Zerr DM, Blume HK, Berg AT, Del Beccaro MA, Gospe SM, Allpress AL, Christakis DA. Nonfebrile illness seizures: a unique seizure category. Epilepsia. 2005;46:952–955. Zerr DM, Corey L, Kim HW, Huang ML, Long N, Boeckh M. Clinical outcomes of HHV-6 reactivation during the course of hematopoietic stem cell transplantation. Clin Infect Dis. 2005;40:932–940. Zerr DM, Garrison MM, Allpress AL, Heath J, Christakis DA. Infection control policies and hospitalassociated infections in surgical patients: variability and associations in a multicenter pediatric setting. Pediatrics. 2005;115:e387–e392. Zerr DM, Meier AS, Selke SS, Frenkel LM, Huang ML, Wald A, Rhoads M, Nguy L, Bornemann R, Morrow RA, Corey L. Virologic and clinical characteristics of primary human herpesvirus 6: a populationbased study. N Engl J Med. 2005;352:768–776. Yeung LC, Cunningham ML, Allpress AL, Gruss JS, Ellenbogen RG, Zerr DM. Surgical site infections following pediatric intracranial surgery for craniofacial malformations: frequency and risk factors. Neurosurg. 2005;56:733–739. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 149 Immunology The section of immunology under the Division of Infectious Disease, Immunology and Rheumatology (in the Department of Pediatrics) provides diagnostic and therapeutic services for children and adults with a suspected or known primary immune deficiency disorder (PIDD). We see patients referred from throughout the WAMI region (Washington, Alaska, Montana, Idaho) and serve as a tertiary referral base for a regional population of more than 10 million. Members of our faculty have played key roles in identifying the molecular basis for many of the now more than 140 molecularly defined PIDDs, and in pioneering clinical care for these diseases. Our faculty also works closely with members of the Fred Hutchinson Cancer Research Center and Seattle Cancer Care Alliance to coordinate care for PIDD patients undergoing hematopoietic stem cell transplants. Our extensive molecular testing program identifies genetic alterations leading to each of the major molecular causes for severe combined immunodeficiency, agammaglobulinemia, hyper-IgM syndromes and common variable immunodeficiency. The immunology diagnostic program also provides high-resolution flow cytometric–based analysis of T and B cell developmental subsets (important for delineating unique developmental defects within distinct PIDDs); expression analysis for potential mutant surface or intracellular proteins; analysis of thymic activity via T cell excision circles; and assessment of T cell repertoire. Additionally, we carry out in vivo evaluations of antibody response to the T cell–dependent neoantigen Bacteriophage X174. These combined approaches provide a unique capacity to evaluate genetic alterations and their effects on the immune system, as well as to monitor immune reconstitution in post-transplant patients. Our research laboratories carry out basic, pre-clinical and clinical research. Because PIDDs represent some of the best candidate disorders for treatment via hematopoietic stem cell gene therapy, our translational research programs include modeling of novel gene and cellular therapies. We also carry out clinical trials related to optimization of immunoglobulin replacement and for non myeloablative hematopoietic stem cell transplant in PIDD. Members of the immunology faculty also hold key international leadership positions in advocacy and research related to PIDD. TEACHING, RESEARCH AND CLINICAL EXPERTISE David J. Rawlings, MD, oversees the immunodeficiency clinical program at Seattle Children’s Hospital and is professor of pediatrics and adjunct professor in the Department of Immunology at the University of Washington School of Medicine. He graduated with honors from the University of North Carolina School of Medicine and completed a residency and chief residency in pediatrics at the University of California, San Francisco. He was an intramural research fellow at the NIH, and a senior fellow at the Howard Hughes Medical Institute, UCLA. He completed specialty training in pediatric rheumatology and immunology at Children’s Hospital Los Angeles. Dr. Rawlings has received numerous awards and was elected to 150 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON the American Society for Clinical Investigation. His primary research interests include dysregulated B cell development and signaling leading to immunodeficiency, autoimmunity or lymphoid malignancies; and the development of gene therapy for primary immune deficiency diseases. His laboratory uses expertise in basic and clinical immunology, signal transduction and lymphocyte developmental biology to understand how altered signals can lead to immunologic disease, with the ultimate goal of developing translational therapies capable of specifically modulating these disorders. Dr. Rawlings is a member of several organizations and ad hoc reviewer for grant programs and immunology journals. Infectious Disease, Immunology and Rheumatology Mark C. Hannibal, MD, PhD, is attending physician at Seattle Children’s Hospital and assistant professor of pediatrics at the University of Washington School of Medicine. He participates in the Immunodeficiency Clinic and the inpatient immunology consult service and is a member of the neurogenetics laboratory. His clinical interests include general clinical genetics, developmental cardiovascular genetics and primary and syndromic immunodeficiencies. He has developed clinical expertise in the diagnosis and management of patients with Kabuki syndrome, a syndrome with craniofacial, congenital heart and developmental anomalies. He teaches genetics to preclinical medical students and students, residents and fellows during clinical rotations. His research interests are in the molecular basis of an episodic painful inflammatory neuropathy, hereditary neuralgic amyotrophy. Carol H. Miao, PhD, is principal investigator in the immunology section at Seattle Children’s Hospital and research assistant professor in the Department of Pediatrics at the University of Washington School of Medicine. Her research focuses on developing gene therapy strategies for treating genetic diseases. Her primary interest is to develop and investigate two prominent gene therapy model systems: hemophilia and primary immunodeficiency disease (PIDD). For hemophilia gene therapy, her study was the first to use non-viral naked DNA delivery to achieve phenotypic correction in hemophilia A and hemophilia B mouse models. Her group is pursuing two projects: development of safer and more efficient non-viral vectors and delivery methods suitable for clinical applications; and immunomodulation strategies involving immunosuppressive regimens and regulatory T cells. Dr. Miao also participates in the gene therapy program for PIDD. A major current focus for these collaborative studies is FACULTY David J. Rawlings, MD, Head Mark C. Hannibal, MD, PhD Carol H. Miao, PhD Hans D. Ochs, MD Andrew M. Scharenberg, MD Troy R. Torgerson, MD, PhD David J. Rawlings MD, Head lentiviral-based gene transfer in animal and cellular models of Wiskott-Aldrich Syndrome (WAS). Dr. Miao is active in many regional, national and international scientific societies; she is a member of the Genetic Diseases Committee of the American Society of Gene Therapy. Hans D. Ochs, MD, is chief of the Immunology Clinic at Seattle Children’s Hospital. He studied medicine in Austria, France and Germany, where he earned his MD from the University of Freiburg. The focus of his research is the molecular definition of primary immunodeficiency diseases and the investigation of new techniques to confirm the diagnosis. He and his collaborators contributed significantly to the identification of a number of genes associated with PIDD located on the X chromosome (CD40L, Wiskott-Aldrich Syndrome, FOXP3, gp91phox) or on autosomes (uracil-DNA glycosulase; Rag1, Rag2 hypomorphic mutations as the cause of Omenn syndrome). As a clinical scientist, Dr. Ochs has initiated clinical trials for new immunoglobulin preparations for intravenous and subcutaneous infusions and has collaborated with the bone marrow transplant team in the design of new protocols for stem cell transplantation and gene therapy. He is principal investigator for US Immune Deficiency Network (USIDnet), co-founder and member of the summer school devoted to primary immune deficiencies and principal editor for two medical textbooks, Primary Immunodeficiency Diseases and Immunological Disorders of Infants and Children. Andrew M. Scharenberg, MD, is attending physician at Seattle Children’s Hospital; he is associate professor in the Department of Pediatrics and adjunct associate professor in the Department of Immunology at the University of Washington School of Medicine. He received his MD with distinction from the University of North Carolina School of Medicine. He completed residency training in pediatrics at the University of North Carolina Children’s Hospital and completed a fellowship in immunology at NIH and at the Division of Experimental Pathology, Beth Israel Hospital. He participates in Seattle Children’s Immunodeficiency Clinic and the inpatient immunology consult service. Dr. Scharenberg’s bench research interests include: signal transduction in immune cells, particularly signaling pathways affected in primary immune deficiencies and those involving ion channels; and application of immune mechanisms of somatic hypermutation to SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 151 Infectious Disease, Immunology and Rheumatology engineering of homing endonucleases. He is working on a new method of gene therapy that would repair the existing DNA strand as a means to treat primary immune deficiencies. Troy R. Torgerson, MD, PhD, is attending physician at Seattle Children’s Hospital and acting assistant professor of pediatrics at the University of Washington School of Medicine. He obtained his MD and PhD from Vanderbilt University School of Medicine and completed residency training in pediatrics and a fellowship in pediatric rheumatology and immunology at the University of Washington. He participates in clinical care of patients with immune deficiency and autoimmune disorders at Seattle Children’s and coordinates care for our patients treated by hematopoietic stem cell transplantation (HSCT). His clinical interests include the diagnosis and management of children and adults with primary immunodeficiency diseases (PIDDs) and children with autoimmune disorders. His research interests relate to the identification of basic cellular mechanisms that jointly promote both autoimmunity and immunodeficiency. His research is focused on studies of the molecular basis of immune dysregulation present in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX). The genetic defect present in this syndrome alters the development and function of regulatory T cells, which are required for controlling immune responses. Dr. Torgerson is co-director of the immunodeficiency molecular diagnostics laboratory at the University of Washington, and he coordinates several joint clinical research protocols designed to optimize HSCT in PIDD. Andrew M. Scharenberg, MD Signaling Competent Transformed Cell Lines for Functional Analysis of PIDD, US Immunodeficiency Network, National Institute of Allergy and Infectious Diseases/NIH/DHHS, $125,000 Targeted Gene Repair of Primary Immune Deficiencies, National Institute of Allergy and Infectious Diseases/ NIH/DHHS, $232,500 TRPM2 HTS Screening Assay Development, National Institute of Neurological Disorders and Stroke/NIH/ DHHS, $108,500 Characterization of a B-Cell Calcium Channel, National Institute of General Medical Sciences/NIH/ DHHS, $265,341 Mechanisms of B-Cell Receptor Calcium Signaling, National Institute of Allergy and Infectious Diseases/ NIH/DHHS, $232,500 Continuing Carol H. Miao, PhD Nonviral Gene Medicine for the Treatment of Hemophilia, National Heart, Lung, and Blood Institute/NIH/DHHS, $387,500 Hans D. Ochs, MD Developmental and Genetic Defects of Immunity, National Institute of Child Health and Human Development/NIH/DHHS, $358,138 United States Immunodeficiency Network, Immune Deficiency Foundation/NAIAD/NIH, $183,937 RESEARCH FUNDING New Carol H. Miao, PhD Gene Delivery of Factor IX by Nonviral Strategies, National Hemophilia Foundation, $70,000 Gene Therapy for Wiskott-Aldrich Syndrome, US Immunodeficiency Network, $150,000 David J. Rawlings, MD TSLP Receptor in the Regulation of B-Cell Development, Benaroya Research Institute at Virginia Mason, National Institutes of Health/DHHS, $90,450 MTCC – Rawlings Pilot, NIDDK/NIH, $75,800 152 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON David J. Rawlings, MD Preclinical Model for Gene Therapy in X-Linked Agammaglobulinemia (XLA), National Cancer Institute/NIH/DHHS, $313,875 Regulation of B-Cell Development and Signaling by BTK and PKCГђ, National Institute of Child Health and Human Development/NIH/DHHS, $348,750 Lentiviral Gene Therapy for X-Linked Agammaglobulinemia, National Heart, Lung, and Blood Institute/NIH/DHHS, $387,500 Infectious Disease, Immunology and Rheumatology Regulation of Lymphopoiesis from Pluripotent Stem Cells, Children’s Hospital, Los Angeles, National Heart, Lung, and Blood Institute/NIH/DHHS, $72,339 Andrew M. Scharenberg, MD ADP Ribose-Dependent Calcium Entry in the Immune System, National Institute of General Medical Sciences/NIH/DHHS, $266,638 Troy R. Torgerson, MD, PhD CHRC: FoxP3 Structure, Function, and Regulation in Human T-Cell, University of Washington, National Institute of Child Health and Human Development/ NIH/DHHS, $88,591 TEACHING AND PRESENTATIONS Mark C. Hannibal, MD, PhD Septin-9 Mutations in Hereditary Neuralgic Amyotrophy, genetics Grand Rounds, University of Washington, Feb 24, 2006 Hereditary Neuralgic Amyotrophy Research in the Context of Peripheral Neuropathies, Neuropathy Association biennial meeting, Minneapolis, May 22, 2005 Kabuki Syndrome, pediatric Grand Rounds, Providence Alaska Medical Center, Anchorage, Alaska, November 29, 2005 Carol H. Miao, PhD Expression Cassette Design, American Society of Gene Therapy, 8th annual meeting, Nonviral Workshop Education Session, St. Louis, June 1–5, 2005 Non-IVIG Therapy of PIDD, Burton Zweiman lectureship, American Academy of Allergy and Asthma & Immunology, IPEX/FOXP3 and Autoimmune Diseases, San Antonio, Texas, March 18–21, 2005 Perspective on History of IVIG, Current Important Problems and Questions in the Field, Workshop on Intravenous Immune Globulin in the 21st Century: Progress and Challenges in the Efficacy, Safety and Paths of Lecture, U.S. Food and Drug Administration, Bethesda, Md., April 12–13, 2005 Immunodysregulation and Immunoreconstitution, FOCIS meeting, Boston, May 10–15, 2005 FOXP3 and Regulatory T Cells: An Endocrinologist’s Nightmare, GeNeSIS Symposium and Investigators Meeting, Washington, D.C., May 18–21, 2005 Regulatory T Cells/T-Cell Development and Function (moderator), IUIS Symposium on Primary Immunodeficiency Diseases, Budapest, Hungary, June 15–19, 2005 Immune Dysregulation, Polyendocrinopathy, Enteropathy (IPEX), Mutations of FOXP3 and Regulatory T Cells, Robertson Parkman immunology lectureship, pediatric Ground Rounds, Children’s Hospital, Los Angeles, July 14–15, 2005 Immune Deficiency Workshop: Evaluating the Patient with Frequent Infections, 8th Annual Scientific Session Intermountain West Allergy Association, “Advances in Allergy and Immunology,” Coeur d’Alene, Idaho, July 28–31, 2005 Gene Therapy and Immunomodulation for Hemophilia Treatment, Abelson Lecture Symposium, Seattle Children’s, August 18, 2005 Clinical Manifestation of PID: Protein Analysis in the Diagnosis of PID, from Flow Cytometry to Western Blotting, Real-Time PCR and Other Tricks, ASCIA conference, Auckland, New Zealand, August 29– September 10, 2005 Hans D. Ochs, MD The Wiskott-Aldrich Syndrome: Multiple Clinical Phenotypes, Molecular Basis, Therapeutic Consequences, LeBein Visiting Professorship, Pediatric Ground Rounds, The University of New Mexico, Albuquerque, N.M., February 23–24, 2005 Disorders of Immunoregulation and Past and Future of Immunodeficiency Diseases, Modell Symposium, University of Zurich, Switzerland, September 14–18, 2005 The Hyper IgM Syndromes, International Meeting on PIDD, Teheran, Iran, February 28–March 2, 2005 Humorale Antikorpermangelsyndrome, German Pediatric Congress, Bremen, Germany, September 28–October 9, 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 153 Infectious Disease, Immunology and Rheumatology The Hyper IgM Syndrome, International Congress on Immune Mediated Diseases, Moscow, October 3–8, 2005 Specific Lentiviral Gene Therapy, 47th American Society of Hematology Annual Meeting and Exposition, Atlanta, December 3–6, 2005 Faculty of the international “summer school” of USIDNET, Miami Beach, Fla., October 13–17, 2005 Gene Therapy of Primary Immunodeficiency Disorders, University of Washington CF Research Seminar Series, University of Washington, December 22, 2005 IPEX and Mutations of FOXP3, Clinical Phenotype and Molecular Consequences, First Brazilian Symposium on Primary Immunodeficiency Diseases, Sao Paolo, Brazil, October 25–November 5, 2005 Immune Dysregulation, Polyendocrinopathy, Enteropathy (IPEX) Syndrome, The Jeffrey Greene Visiting Professorship, Children’s Hospital of Philadelphia, December 6–7, 2005 The Wiskott-Aldrich Syndrome, Modell Symposium, Haifa, Israel, December 11–17, 2005 David J. Rawlings, MD Molecular Mechanism(s) Controlling PKC-Dependent, Immunoreceptor-Induced NF-kappaB Activation and chair of workshop on B-cell signaling, Keystone Symposia Steamboat Springs, Col., March 28– April 3, 2005 Andrew M. Scharenberg, MD TRPM2 Cation Channels and Oxidative Stress Signaling, American Academy of Allergy Asthma & Immunology, San Antonio, Texas, March 18–22, 2005 Role of Cation Channels and Transporters in B-Cell Biology, US/Japan Talk, University of Washington, June 26, 2005 Primary Immunodeficiencies: Models for Immune Reconstitution, Abelson Lecture Symposium, Seattle Children’s, August 18, 2005 Physiological Roles of TRPM Channel/Enzymes, physiology department seminar, University of Toronto, September 22–24, 2005 Regulation of CARMA1-Mediated NF-ГђB Signaling via PKC Isoforms in B and T Lymphocytes, Cantoblanco workshops on “Signaling Networks in Immunity and Inflammation,” Madrid, Spain, May 22–24, 2005 Troy R. Torgerson, MD, PhD Analysis of the Genotype of a Large Cohort of IPEX Patients Identifies Key Domains of FOXP3 Required for Its Function, Federation of Clinical Immunology Societies annual meeting, Boston, May 11–16, 2005 Btk-Dependent Events Controlling Calcium and NF-kB Signaling in B Lymphocytes, 3rd Lymphocyte Signal Transduction Workshop, Crete, Greece, May 27– June 1, 2005 The Intersection Between Autoimmunity and Immunodeficiency – An Accident Waiting to Happen, pediatric Grand Rounds, Children’s Memorial Hospital, Chicago, October 7, 2005 Lentiviral Vector-Mediated Gene Therapy as Treatment for Wiskott-Aldrich Syndrome (WAS): Pre-Clinical Studies in Human Cell Lines and WASp -/- mice, American Society for Gene Therapy 8th annual meeting, St. Louis, Miss., June 1–5, 2005 Eosinophilic Gastroenteritis from an Immunologist’s Perspective, gastroenterology Grand Rounds, University of Washington, January 6, 2006 PUBLICATIONS Distinct Signaling Responses of Transitional B-Cell Subsets and Their Developmental Consequences, 7th Latin American Congress of Immunology, Cordoba, Argentina, October 2–6, 2005 Rescue of B Cells Development in an Animal Model of X-Linked Agammaglobulinemia (XLA) via B lineage- 154 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Bearden CM, Agarwal A, Book BK, Vieira CA, Sidner RA, Ochs HD, Pescovitz MD. Rituximab inhibits the in vivo primary and secondary antibody response to a neoantigen, bacteriophage phiX174. Am J Transplant 2005;5:50–57. Infectious Disease, Immunology and Rheumatology Bindl L, Torgerson T, Perroni L, Youssef N, Ochs HD, Goulet O, Ruemmele F. Successful use of the new immune-suppressor siromlimus in IPEX (immune dysregulation, polyendorcrinopathy, enteropathy, X-linked syndrome). J Pediatrics 2005;147:256–259. Dorshkind K, Rawlings DJ. B cell development. In: Hematology: Basic Principles and Practice, 4th Edition. Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, McGlave P, eds. Philadelphia: Elsevier, 2005, 11:119–133. Hannibal MC, Chance PF. CMT2, dominant intermediate CMT and CMTX. In: Hereditary Peripheral Neuropathies. Kuhlenbaumer G, Stogbauer F, Ringelstein EB, Young P, eds. Steinkoppff Springer, Darmstadt, 2005, 121–145. Hawn T, Ozinsky A, Williams L, Rodrigues S, Clark A, Pham U, Hill H, Ochs HD, Aderem A, Liles C. Hyper-IgE syndrome is not associated with defects in several candidate toll-like receptor pathway genes. Human Immunology 2005;66:842–847. Huang Y-T, Lin S-L, Miao CH, Hwang L-H. In vivo functions of hepatitis C virus core protein: a study in a mouse model generated by hydrodynamics-based DNA injection of the core-expressing DNA. J Genet and Mol Biology 2005;16:40–55. Huang W, Ochs HD, Dupont B, Vyas YM. The Wiskott-Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF-ГђB (Re1A) independently of its role in filamentous actin polymerization and actin cytoskeletal rearrangement. J Immunol 2005;174:2602–2611. Humblet-Baron S, Anover S, Kipp K, Zhu Q, Ye P, Zhang W, Ovechkina Y, Khim S, Astrakhan A, Strom T, Kohn D, Candotti F, Vyas Y, Ochs H, Miao C, Rawlings DJ. Lentiviral vector-mediated gene therapy as treatment for Wiskott-Aldrich syndrome (WAS): pre-clinical studies in human cell lines and WASp -/- mice. Molecular Therapy 2005;11(1): S133. Humblet-Baron W, Zhang K, Kipp S, Khim J, Jarjour K, Sommer KM, Rawlings DJ. Rescue of B cells development in an animal model of X-linked agammaglobulinemia (XLA) via B lineage-specific lentiviral gene therapy. The American Society of Hematology 47th annual meeting 2005. Abstract #1287 appears in Blood. Nov 16 2005;06(11). Johnston JJ, Olivos-Glander I, Killoran C, Elson E, Turner JT, Peters KF, Abbott MH, Aughton DJ, Aylsworth AS, Bamshad MJ, Booth C, Curry CJ, David A, Dinulos MB, Flannery DB, Fox MA, Graham JM, Grange DK, Guttmacher AE, Hannibal MC, Henn W, Hennekam RC, Holmes LB, Hoyme HE, Leppig KA, Lin AE, Macleod P, Manchester DK, Marcelis C, Mazzanti L, McCann E, McDonald MT, Mendelsohn NJ, Moeschler JB, Moghaddam B, Neri G, NewburyEcob R, Pagon RA, Phillips JA, Sadler LS, Stoler JM, Tilstra D, Walsh Vockley CM, Zackai EH, Zadeh TM, Brueton L, Black GC, Biesecker LG. Molecular and clinical analyses of Greig cephalopolysyndactyly and Pallister-Hall syndromes: robust phenotype prediction from the type and position of GLI3 mutations. Am J Hum Genet 2005;76:609–22. Kuhlenbaumer G, Hannibal MC, Nelis E, Schirmacher A, Verpoorten N, Meuleman J, Watts GD, Vriendt ED, Young P, Stogbauer F, Halfter H, Irobi J, Goossens D, Del-Favero J, Betz BG, Hor H, Kurlemann G, Bird TD, Airaksinen E, Mononen T, Serradell AP, Prats JM, Broeckhoven CV, Jonghe PD, Timmerman V, Ringelstein EB, Chance PF. Mutations in SEPT9 cause hereditary neuralgic amyotrophy. Nat Genet 2005;37:1044–1046. Lee WI, Torgerson TR, Schumacher MJ, Yel L, Zhu Q, Ochs HD. Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome. Blood 2005;105:1881–1890. Levin SD, Rawlings DJ, Ziegler SD, Farr AG. TSLP (thymic stromal lymphopoietin). In: Encyclopedia of Hormones. 1st Edition. Henry HL, Norman AW, eds. San Diego, CA: Academic Press, 2005. Mazzolari E, Forino C, Fontana M, D’Ippolito C, Lanfranchi A, Gambineri E, Ochs HD, Badolato R, Notarangelo LD. A new case of IPEX receiving bone marrow transplantation. Bone Marrow Transplant 2005;35:1033–1034. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 155 Infectious Disease, Immunology and Rheumatology McDermott DA, Bressan MA, He J, Lee JS, Aftimos S, Brueckner M, Gilbert F, Graham GE, Hannibal MC, Innis JW, Pierpont ME, Raas-Rothschild A, Shanske AL, Smith WE, Spencer RH, St John-Sutton MG, van Maldergem L, Waggoner DJ, Weber M, Basson CT. TBX5 genetic testing validates strict clinical criteria for Holt-Oram syndrome. Pediatr Res 2005;58: 981–986. Perraud AL, Takanishi CL, Shen B, Kang S, Smith MK, Schmitz C, Knowles HM, Ferraris D, Li W, Zhang J, Stoddard BL, Scharenberg AM. Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J Biol Chem. Feb 18, 2005;280(7):6138–48; e-publication, Nov 23, 2004. Miao CH. A novel gene expression system: non-viral gene transfer for hemophilia as model systems. Adv Genet 2005;54:143–177. Rajaiya J, Hatfield M, Nixon JC, Rawlings DJ, Webb CF. Bruton’s tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor bright. Molec Cell Biol 2005;25(6):2073–2084. Miao CH, Brayman AA, Loeb KR, Ye P, Zhou L, Mourad P, Crum LA. Enhancement of nonviral gene transfer of factor IX into mouse livers by ultrasound. Human Gene Therapy 2005;16: 893–905. Moreno-Garcia ME, Lopez-Bojorques LN, Zentella A, Humphries LA, Rawlings DJ, Santos-Argumedo L. CD38 signaling regulates B lymphocyte activation via a PLCГђ2 independent, PKC, phosphatidylcholine-PLC and PLD-dependent signaling cascade. J Immunol 2005;174(5):2687–2695. Nicolay U, Kiessling P, Berger M, Gupta S, Yel L, Roifman C, Gardult A, Eichmann F, Hagg S, Massion C, Ochs HD. Health-related quality of life and treatment satisfaction in North American patients with primary immunedeficiency diseases receiving subcutaneous IgG self-infusions at home. J Clin Immunol 2005;26: 65–72. Notarangelo L, Ochs HD. WASp and the phenotypic range associated with deficiency. Curr Opin Allergy Clin Immunol 2005;6:485–490. Ochs HD, Notarangelo L. Structure and function of the Wiskott-Aldrich syndrome protein. Curr Opin Hematol 2005;12:284–291. Ochs HD, Ziegler SF, Torgerson TR. FOXP3 acts as a rheostat of the immune response. Immunol Rev 2005;203:156–164. Oda A, Miki H, Wada I, Yamaguchi H, Yamazaki D, Suetsugu S, Nakajima M, Nakayama A, Okawa K, Miyazaki H, Matsuno K, Ochs HD, Machesky LM, Fujita H, Takenawa T. WAVE/SCARS in platelets. Blood 2005;105:3141–3148. 156 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Scharenberg AM. TRPM2 and TRPM7: channel/ enzyme fusions to generate novel intracellular sensors. Pflugers Arch. Oct 2005;451(1):220–227; e-publication, Jul 7, 2005. Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-GarcГa ME, Ovechkina YL, Rawlings DJ. Phosphorylation of the CARMA1 linker controls NF-ГђB activation. Immunity 2005;23(6):561–574. Vogt G, Chapgier A, Yang K, Chuzhanova N, Feinberg J, Fieschi C, Boisson-Dupuis S, Alcais A, Filipe-Santos O, Bustamante J, de Beaucoudrey L, Al-Mohsen I, Al-Hajjar S, Al-Ghonaium A, Adimi P, Mirsaeidi M, Khalilzadeh S, Rozensweig S, de la Calle Martin O, Bauer TR, Puck JM, Ochs HD, Furthner D, Engelhorn C, Belohradsky B, Mansouri D, Holland SM, Schreiber RD, Abel L, Cooper DN, Soudais C, Casanova JL. Gains of glycosylation comprise an unexpected large group of pathogenic mutations. Nature Genetics 2005;37:692–700. Wolf HM, Ochs HD. StГ¶rungen der humoralen ImmunitГ¤t (B-Zellen). In: PГ¤diatrische Allergologie und Immunologie. Wahn U, Seger R, Wahn V, HollГ¤nder G, ed. Germany: Elsevier, Urban & Fischer. 2005, 551–568. Worlein J, Leigh J, Larsen K, Kinman L, Schmidt A, Ochs HD, Ho R. Cognitive and motor deficits associated with HIV-2(287) infection in infant pigtailed macaques: a nonhuman primate model of pediatric neuro-AIDS. J Neurovirol 2005;11:34–45. Rheumatology The section of rheumatology under the Division of Infectious Disease, Immunology and Rheumatology (in the Department of Pediatrics) provides consultation for children with possible inflammatory, musculoskeletal and autoimmune problems, and comprehensive ongoing management for children who have childhood onset arthritis, spondyloarthropathies, dermatomyositis, systemic lupus erythematosus and other rheumatic diseases. Our team comprises physicians with expertise in childhood rheumatic diseases and allied health professionals from nursing, physical and occupational therapy, social work and nutrition. As many of our children have multisystem diseases, we work closely with other specialties such as ophthalmology, nephrology and orthopedics. We are the only pediatric rheumatology resource in the WAMI region (Washington, Alaska, Montana, Idaho), and we provide telephone consultation and triage for physicians in our area, as well as outreach clinics in Anchorage, Alaska. We provide physician and allied health education in the region through continuing education seminars. We are members of the Childhood Arthritis and Rheumatology Research Alliance, a national network of pediatric rheumatology centers that undertakes collaborative studies to improve understanding of the causes of rheumatic diseases in children and to improve the care of children with these diseases. We offer the opportunity for patients to participate in a number of clinical studies. Our staff works closely with the Pacific Northwest Chapter of the Arthritis Foundation for parent support and advocacy. All our physicians are involved with basic or clinical investigation into the mechanisms, management or outcomes of childhood rheumatic diseases. Pediatric rheumatology is an underserved field with only two hundred board-certified pediatric rheumatologists for the estimated 385,000 children in the United States who have rheumatic diseases. About one third of medical schools do not have a pediatric rheumatologist, and many practicing pediatricians and family physicians have had no training in these conditions. The section of rheumatology maintains a strong teaching presence with residents and fellows at the university. TEACHING, RESEARCH AND CLINICAL EXPERTISE Helen Emery, MD, is chief of the Rheumatology Clinic, program director of Rheumatology Education and attending physician at Seattle Children’s Hospital. She completed a pediatrics residency and a fellowship FACULTY Helen Emery, MD, Chief Victoria W. Cartwright, MD, MS Anne M. Stevens, MD, PhD Carol A. Wallace, MD Helen Emery MD, Chief in pediatric rheumatology at Seattle Children’s. She established pediatric rheumatology programs at the University of Chicago and the University of California, San Francisco. Her clinical interests involve care of children with rheumatic diseases, with a special emphasis on rehabilitation of children with juvenile arthritis and dermatomyositis, for which she has an international reputation. Her educational activities have been focused on community physicians, including a project to present educational seminars to primary care physicians, adult rheumatologists and orthopedists about the diagnosis and management of childhood rheumatic diseases; the project also tracks whether children are referred earlier and more appropriately, and their level of impairment. Dr. Emery regards training of new investigators and clinicians as a top priority and has graduated many trainees, all of whom hold academic positions. She has received an American College of Rheumatology Clinician Educator Award, which enabled the expansion of educational SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 157 Infectious Disease, Immunology and Rheumatology efforts into the medical school musculoskeletal curriculum. She is an executive member of the Pacific Northwest Arthritis Foundation Chapter and has been involved with the chapter’s parent group activities. Victoria W. Cartwright, MD, MS, is attending physician at Seattle Children’s Hospital, clinical assistant professor in the Department of Epidemiology at the University of Washington School of Public Health and clinical assistant professor in the Department of Pediatrics at the University of Washington School of Medicine. She received her MD from the Uniformed Services University of the Health Sciences in Bethesda, Md., and her MS in epidemiology from the University of Washington. Dr. Cartwright’s research is focused on rheumatic diseases, particularly in children. She is engaged in two studies utilizing a rheumatic diseases database, which includes a cohort followed since 1976 and a study of pregnancy outcomes in patients with systemic lupus erythematosus. Dr. Cartwright is chief of pediatric rheumatology, clerkship director of pediatrics and assistant residency program director at Madigan Army Medical Center. Anne M. Stevens, MD, PhD, is attending physician at Seattle Children’s Hospital and assistant professor at the University of Washington School of Medicine. She completed her residency in pediatrics at the Children’s Hospital Medical Center in Cincinnati and a fellowship in pediatric rheumatology at the University of Washington. In the Rheumatology Clinic and inpatient service at Seattle Children’s Hospital, Dr. Stevens cares for children with chronic inflammatory diseases and teaches residents and students. Her research interest is in the role that maternal cells, passing into the fetus during pregnancy and persisting for years in the child, play in the pathogenesis of autoimmune diseases. She demonstrated that maternal cells can differentiate into myocardial cells in the hearts of infants with neonatal lupus syndrome, where these foreign cells may act as targets for the child’s immune system. Alternatively, maternal cells may respond to tissue injury and aid in repair. Dr. Stevens is studying the immune response to chimeric maternal cells in children with lupus and a mouse model investigating the role of maternal cells in renal injury. Dr. Stevens is a co-investigator on studies of Lipitor (atorvastatin), etanercept and the long-term outcome of juvenile rheumatoid arthritis. 158 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Carol A. Wallace, MD, is attending physician at Seattle Children’s Hospital and associate professor of pediatrics at the University of Washington School of Medicine. She received her MD from the University of Michigan. She completed a pediatrics residency and a fellowship in pediatric rheumatology at the University of Washington. Dr. Wallace’s main focus has been the aggressive treatment of juvenile idiopathic arthritis (JIA) and other pediatric rheumatic diseases. She has published many of the sentinel studies of the use of methotrexate in the treatment of JIA. She is co-principal investigator for a national collaborative study of autologous stem cell transplantation for severe pediatric rheumatologic diseases, and participates in many multicenter clinical trials of new biologic agents for the treatment of JIA. With remission of disease as the goal of treatment, Dr. Wallace helped to develop an international consensus definition for remission of JIA. Dr. Wallace has served on the Pediatric Rheumatology Sub-board for the American Board of Pediatrics and sub-committees of the American College of Rheumatology. She is on the Advisory Committee of the Pediatric Rheumatology Collaborative Study Group and is vice chair of the Childhood Arthritis and Rheumatology Research Alliance. AWARDS AND HONORS Helen M. Emery, MD “America’s Top Doctors,” 2005 RESEARCH FUNDING New Anne M. Stevens, MD, PhD Maternal Microchimerism in Pediatric Systemic Lupus Erythematosus, Arthritis National Research Foundation, $75,000 Potential Implications of Maternal Microchimerism in Acute Renal Disease, National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS, $181,000 Fibrotic Sequelae of Childhood Renal Disease, Vanderbilt University, National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS, $62,000 Infectious Disease, Immunology and Rheumatology Carol A. Wallace, MD Retrospective Validation of Draft Criteria for Clinical Remission of Juvenile Rheumatoid Arthritis, Centocor, Inc., $68,950 A Phase III, Multi-Center, Multi-National, Randomized Withdrawal Study to Evaluate the Safety and Efficacy of BMS-188667 in Children and Adolescents with Active Polyarticular Juvenile Rheumatoid Arthritis (JRA), IM101-033, Bristol Myers Squibb Immunology, $101,733 Continuing PUBLICATIONS Mullarkey ME, Stevens AS, McDonnell WM, Loubiere LS, Brackensick JA, Pang JM, Porter AJ, Galloway DA, Nelson JL. HLA Class II alleles in Caucasian women with primary biliary cirrhosis. Tissue Antigens. 2005;65(2):199–205. Stevens AS. Maternal microchimerism – Allogeneic target of autoimmune disease or normal biology? Clin Appl Immunol Rev. 2005;5:325–338. Helen Emery, MD Early Identification and Intervention for Children with Rheumatic Disease, Arthritis National Research Foundation, $275,079 Stevens AS, Tsao BP, Hahn BH, Guthrie K, Gazinski A, Lambert NC, Porter AJ, Tylee TA, Nelson JL. Maternal HLA class II compatibility in males with systemic lupus erythematosus. Arthritis Rheum. 2005;52(9):2768–2773. Carol A. Wallace, MD A Phase 4 Safety and Efficacy Study of Etanercept in Children with Systemic Onset Juvenile Rheumatoid Arthritis, Amgen Inc., $94,908 Wallace CA, Huang B, Bandeira M, Ravelli A, Giannini EH. Patterns of clinical remission in select categories of juvenile idiopathic arthritis (JIA). J Rheumatol. 2005;31(11):2290–2294. Phase IV Registry of Etanercept (Enbrel) in Children with Juvenile Rheumatoid Arthritis, Amgen,Inc., $130,625 Yan Z, Lambert NC, Guthrie KA, Porter AJ, Loubiere LS, Madeleine MM, Stevens AM, Hermes HM, Nelson JL. Male microchimerism in women with no prior birth of a son: quantitative assessment and correlation with pregnancy history. Am J Med. 2005;118:899–906. TEACHING AND PRESENTATIONS Helen Emery, MD Abe Schorr Visiting Professor, Halifax, Nova Scotia, Canada Carol A. Wallace, MD Rituximab Treatment of TMJ Disease, XII European Paediatric Rheumatology Congress, Versailles, France SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 159 Neonatology The Division of Neonatology (in the Department of Pediatrics) is a key component of Seattle Children’s Hospital’s neonatal programs. The division’s mission is to improve the neonatal outcome of pregnancy by providing the region’s best evidence-based neonatal clinical care, educating the next generation of neonatal caregivers and advancing neonatal scholarship. Neonatology division faculty provide clinical service and medical direction at four regional neonatal intensive care units (NICUs). The 19-bed NICU at Seattle Children’s provides care for critically ill newborns and infants with a wide variety of problems including prematurity, infection and cardiac and surgical defects. Key services include inhaled nitric oxide treatment, high-frequency ventilation, and extra-corporeal membrane oxygenation (ECMO). The University of Washington Medical Center is equipped to handle some of the highest-risk deliveries in the nation, and its 32-bed NICU specializes in maternal hypertension, diabetes and preterm birth. The 29-bed NICU at Providence Everett Medical Center serves high-risk newborns in the north end of the Seattle region. Division faculty direct and provide services in a 14-bed NICU at Overlake Hospital Medical Center, on the east side of Lake Washington. Infants needing high-level care or cardiac and surgical services are transferred to University Hospital or Seattle Children’s. Division training programs include an American College of Graduate Medical Education (ACGME)–accredited fellowship training program, plus medical student and pediatric resident education. Several fellows choose to combine training in neonatology with a complementary MPH. Division faculty also participate in and direct regional educational programs in the WAMI region (Washington, Alaska, Montana, Idaho), Infant Transport Program, Medical Consultation Program (MedCon) and the High-Risk Infant Follow-up Clinic. Faculty research interests include bench research, clinical trials, bioethics, informatics, computer simulation and continuous quality improvement. In 2005, research programs addressed cerebral physiology and neuropathology, fetal alcohol syndrome, developmental biology (erythropoietin), pediatric safety and biomedical informatics, in addition to participation in several multicenter clinical trials. TEACHING, RESEARCH AND CLINICAL EXPERTISE Christine A. Gleason, MD, is chief of the Division of Neonatology at Seattle Children’s Hospital and is W. Alan Hodson professor of pediatrics and head of the Division of Neonatology at the University of Washington School of Medicine. Dr. Gleason’s primary clinical interest is the care of high-risk newborns, especially infants born at the limits of viability (23–24 weeks gestation). Her research has been focused on the development of cerebral circulation, specifically the effects of drugs such as cocaine and alcohol on the developing brain. She and her colleagues are trying to understand the long-term effects of severe neonatal stress — and the attempts to ameliorate these effects with narcotics — on the developing brain. Her local 160 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON teaching activities are focused on didactic teaching of pediatric residents and neonatology fellows in the NICUs at Seattle Children’s and University of Washington Medical Center; research teaching and mentorship of neonatology fellows; and teaching newborn resuscitation and basic stabilization procedures to ground transport team and Airlift Northwest team members. Regionally, she teaches as a visiting professor, does case reviews and presentations at regional hospitals and has been invited to serve as a visiting professor at academic medical centers. Shilpi Chabra, MD, is medical director of the special care nursery at Overlake Hospital Medical Center and assistant professor of pediatrics at the University of Washington School of Medicine. Dr. Chabra has a keen Neonatology interest in teaching residents and fellows. Her scholarly interests include neonatal lymphocyte subsets and steroid effects, chronic lung disease in preterm infants and its association with vitamin A and epidemiology of birth defects. She is also involved in quality improvement projects in the Overlake NICU and has helped establish the post-discharge nutrition clinic at Overlake Hospital. Dr. Chabra also coordinates the division’s regional outreach activities. Eric Demers, MD, is associate medical director of neonatology at Seattle Children’s Hospital and acting assistant professor of pediatrics at the University of Washington School of Medicine. He completed a neonatal fellowship at the university. Dr. Demers’ patient care responsibilities rotate among the NICUs at the University of Washington, Seattle Children’s and Providence Everett Medical Center. His area of scholarship is in the improvement of care delivered to neonatal patients through the creation of evidencebased care guidelines in the intensive care setting and during inter-facility transport. He is also active in the education and training of the neonatal ground transport team at Children’s. W. Alan Hodson, MD, MMSc, is professor emeritus of pediatrics at the University of Washington School of Medicine. He works part-time teaching clinical neonatology to residents and neonatal fellows. He was head of the Division of Neonatal and Respiratory Diseases at the University of Washington. His interests and activities include providing assistance and guidance to postdoctoral fellows in their pursuit of excellence as scholars in neonatal medicine, providing clinical service to convalescing premature infants and teaching overall neonatal medicine, fundamental to general pediatrics training. He is also involved in enhancing FACULTY Christine A. Gleason, MD, Chief Shilpi Chabra, MD Eric Demers, MD W. Alan Hodson, MD, MMSc J. Craig Jackson, MD Sandra Juul, MD, PhD David Loren, MD Dennis E. Mayock, MD Christine A. Gleason MD, Chief and improving the participation of other pediatric sub-specialists in the evolving field of fetal medicine. He has developed an interest in global neonatal health issues: He is involved with the newly formed Department of Global Health at the University of Washington and in the development of a curriculum for pediatric residents and post residents interested in global health training. He continues a long-standing interest in neonatal respiratory disorders and is currently chair of the NHLBI External Advisory Committee for the Collaborative Program (U-10) on Bronchopulmonary Dysplasia. J. Craig Jackson, MD, is medical director of the NICU at Seattle Children’s Hospital and professor of pediatrics at the University of Washington. He serves as associate division head for clinical activities at the university. After 15 years of basic and clinical research in lung diseases of newborns, Dr. Jackson has changed his direction from research to neonatal medical direction services. He is enrolled in the executive MHA program at the University of Washington. He is active in quality improvement and works with leaders in perinatology at the university to build its program in maternal-fetal medicine and fetal diagnostic services. Dr. Jackson provides support for the division’s neonatal medical directors at Seattle Children’s, University Hospital, Providence Hospital in Everett and Overlake Hospital in Bellevue, Wash. The clinical programs of the division include direction of the Children’s infant ground transport team and medical support for the neonatal nurse practitioner program. Sandra Juul, MD, PhD, is director of the neonatology fellowship at Seattle Children’s Hospital; she is associate professor of pediatrics and associate division head for scholarship and research at the University of Washington. She is also director of the fellowship training program. Dr. Janet Haworth Murphy, MBChB Juul completed medical Michael D. Neufeld, MD, MPH training and pediatric Kendra Smith, MD and neonatology Thomas P. Strandjord, MD subspecialty training Peter Tarczy-Hornoch, MD at the University of David E. Woodrum, MD Washington. She earned a PhD in developmental biology at the University of Chicago. Dr. Juul is principal investigator SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 161 Neonatology on studies focusing on the neuroprotective effects of erythropoietin (Epo) in neonatal models of brain injury and neonatal stress. She has identified Epo and its receptor in the developing human brain, demonstrated the functionality of the Epo receptor on cultured neurons and documented Epo in the spinal fluid of human neonates. Her research shows that Epo protects the neonatal brain from hypoxia and oxidative injury. Using a variety of approaches, Dr. Juul is working to identify mechanisms of Epo neuroprotection and to discover ways to optimize its function in the developing brain at risk for injury. Her ultimate goal is to bring this new treatment from the laboratory to the bedside. David Loren, MD, is acting assistant professor of pediatrics at the University of Washington. He teaches and supports medical students, residents and fellows at all of Seattle Children’s Hospital’s clinical practice sites. Dr. Loren’s teaching and research interests focus around the triangle of practical medical ethics, quality improvement and communication. He has developed a parent-as-faculty program in the infant ICU at Seattle Children’s that helps medical teams improve their communication skills with families. He is also part of the family-centered care leadership team at Seattle Children’s. In the University of Washington Medical Center NICU, Dr. Loren helps guide the quality leadership team, which recently completed an international collaboration with Vermont Oxford Network on reduction of nosocomial infection. His work in quality of care has focused around how culture and individual behavior support or inhibit strategies for process improvement. He is a participant in the inaugural Pediatric Academic Societies Educational Scholars Program, and he leads a research project to develop a Web-based teaching program for pediatric residents on safe and effective practices for disclosing medical errors. Dennis E. Mayock, MD, is professor of pediatrics at the University of Washington School of Medicine, medical director of the University of Washington Medical Center NICU and director of the infant ground transport team. Dr. Mayock’s basic research interests include evaluation of the effects of fetal alcohol exposure on fetal, neonatal and adult cerebrovascular function. Additionally, he is evaluating the effects of neonatal morphine exposure on adult cerebrovascular function. These studies include testing isolated 162 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON cerebral resistance vessels and evaluation of specific vasoactive mediators such as adenosine and vasoactive intestinal polypeptide. Dr. Mayock’s clinical research interests include evaluation of therapies, such as inhaled nitric oxide and late surfactant treatments, that may alter the development of chronic lung disease. He is collaborating on an evaluation of whether high-dose erythropoietin treatment has neuroprotective effects in preterm infants. Janet H. Murphy, MBChB, is medical director of Seattle Children’s Hospital’s neonatal nurse practitioner program, associate professor of pediatrics at the University of Washington School of Medicine and administrator of the Northwest regional perinatal program. Dr. Murphy attends at the University of Washington NICU and Newborn Plus Service, Overlake Hospital Medical Center and Evergreen Hospital Medical Center. She serves on the university Infection Control Committee and is a founding member of the Perinatal Family Centered Care Committee. Dr. Murphy’s primary research interest is lung development and physiology. She has participated in education programs and clinical case reviews for obstetric and neonatal care providers in Washington, with particular emphasis on neonatal resuscitation and the Neonatal Resuscitation Program (NRP) of the American Academy of Pediatrics. Her education focus for pediatric residents has been on bedside teaching, review of common problems in neonatology and NRP education and testing; her focus on NRP extends to University of Washington residents in family practice and obstetrics and gynecology. Michael D. Neufeld, MD, MPH, is associate medical director of the NICU at Providence Everett Medical Center and acting assistant professor at the University of Washington. Dr. Neufeld is interested in long-term neurodevelopmental outcomes of premature infants. His research focuses on maternal infection and the risk of cerebral palsy in term and preterm infants and on markers of inflammation and the risk of severe retinopathy of prematurity. He helps manage the division’s clinical database and is developing a database of the patients seen in the High-Risk Infant Follow-up Clinic. Other interests include quality improvement and medical education. Neonatology Kendra Smith, MD, is medical director of the NICU at Providence Everett Medical Center and assistant professor of pediatrics at the University of Washington. The community-based NICU integrates neonatology with hospital units at the university and Seattle Children’s Hospital units and with perinatology at the University of Washington. Dr. Smith’s focus in research has been in lung injury and its prevention in the preterm neonate. She has studied ventilator techniques and different ventilation support modalities and is working clinically on strategies to minimize lung trauma in infants requiring ventilation due to respiratory failure at birth. She serves as manager of divisional respiratory care programs with the goal of promoting improved ventilation strategies for neonates in our region. Dr. Smith is also interested in brain injury in neonates and is site investigator at Providence Everett Medical Center for clinical trials in preterm infants at risk for altered neurological outcome using erythropoietin as a potential neuroprotective agent. Thomas P. Strandjord, MD, is associate medical director of the NICU at Evergreen Hospital Medical Center and associate professor of pediatrics at the University of Washington. He is chair of University of Washington Medical Center’s Perinatal/Neonatal Continuous Quality Improvement Committee. Dr. Strandjord’s primary clinical interests involve care of critically ill newborn infants. He is particularly interested in the initial stabilization and resuscitation of neonates, and his research focuses on developing techniques for training care providers to resuscitate newborns effectively and safely. He has collaborated in the development of a screen-based computer simulator of newborn resuscitation and is studying its effectiveness as a training tool. Dr. Strandjord is also working on various quality improvement projects for the safety of care in the NICU. methods and models from the computing, information and behavioral sciences into tools and solutions for care providers, patients, biomedical researchers and public health providers. Dr. Tarczy-Hornoch’s own BHI research has included real-time biomedical instrumentation control systems, bench research and mathematical modeling of liquid ventilation, clinical information systems and electronic clinical knowledge resources. He collaborates with biologists and clinical researchers looking at large-scale functional gene annotation of bacteria and protozoans, single nucleotide polymorphisms for elucidation of disease mechanisms, expression array experiment analysis and collaborative integrated analysis of a combination of clinical data, experimental biological data and clinical/ translational research study data. David E. Woodrum, MD, is attending physician at Seattle Children’s Hospital and professor of pediatrics at the University of Washington School of Medicine. He is a member of the Treuman Katz Bioethics Center and faculty associate in the Department of Medical History & Ethics at the University of Washington. Dr. Woodrum’s clinical and teaching activities are focused on convalescing premature infants and on pediatric biomedical ethics issues for residents, fellows and other health care providers. His research explores the determinative elements of parental decision making. AWARDS AND HONORS Eric Demers, MD Fellow’s Research Day Basic Science Award, Seattle Children’s RESEARCH FUNDING New Peter Tarczy-Hornoch, MD, is associate professor of pediatrics and of medical education and biomedical informatics at the University of Washington; he is also adjunct associate professor of computer science and engineering. He serves as the head of the Division of Biomedical and Health Informatics (BHI) and as associate division head for Evidence Based Education in Neonatology. University BHI researchers — 17 core faculty, 27 adjunct and affiliate faculty, 35 students — play a leadership role in translating and advancing Peter Tarczy-Hornoch, MD II+(SEI): Information Integration in the Presence of Uncertainty, NSF, $103,111 Continuing Christine A. Gleason, MD Cerebrovascular Effects of Prenatal Alcohol, NIAAA/ NIH, $358,869 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 163 Neonatology Sandra Juul, MD, PhD Nonhematopoietic Developmental Functions of Epo, NICHD/NIH, $165,852 Diagnosis and Management of Gastroesophageal Reflux in Neonates, Contemporary Forum’s Conference on Neonatal Pharmacology, Seattle, June 17, 2005 Epo as a Rescue Agent for Perinatal Hypoxia-Ischemia, NICHD/NIH, $170,255 Sandra Juul, MD, PhD Recombinant Epo as a Neuroprotectant, AAP Perinatal Section, District VIII, Midway, Utah, June 24, 2005 Peter Tarczy-Hornoch, MD BioMediator: Biological Data Integration & Analysis System, NHGRI/NIH, $336,551 TEACHING AND PRESENTATIONS Eric Demers, MD Congenital Diaphragmatic Hernia, Controversies in Neonatal-Perinatal Care Conference Series, University of Washington, September 16, 2005 Christine A. Gleason, MD Contemporary Forums, co-chair/director, Neonatal Pharmacology Conference, June 17, 2005 Management of Neonatal Pain and Sedation: Do We Know What We’re Doing? University of Iowa pediatric Grand Rounds, Iowa City, 2005 Chronic Neonatal Morphine: Effects on the Developing Brain, Iowa Neonatology Day, Iowa City, 2005 Management of Neonatal Pain and Sedation: Do We Know What We’re Doing? University of Rochester pediatric Grand Rounds, Rochester, N.Y., 2005 164 Update on Neuroprotection in Neonates: Can Epo Make a Difference?, Perinatal Research Society Meeting, Quebec, September 17, 2005 Visiting professorship, University of Utah, Salt Lake City David Loren, MD Family-Centered Perinatal-Neonatal Care, Controversies in Neonatal-Perinatal Care Conference Series, University of Washington, May 27, 2005 Neonatal End of Life and Bereavement, guest lecturer, Anthropology 322, University of Washington, 2005 Dennis E. Mayock, MD Oxygen Use at Delivery: Poisoning with the First Breath?, Association of Women’s Health, Obstetric, and Neonatal Nurses, Washington Section, October 18, 2005 Janet H. Murphy, MBChB Examination of the Newborn, Rehab 400, University of Washington, January 10, 2005 Visiting professorship, University of Rochester, Rochester, New York; University of Iowa, Iowa City Clinical Case Discussion and NRP Testing, pediatricians and family physicians, Valley General Hospital, Monroe, Wash., April 18, 2005 J. Craig Jackson, MD NeoSim Computer Simulation Program on CD for Teaching Neonatal Resuscitation, AnaeSoft, 2005 Room Air Resuscitation and Neonatal Hyperbilirubinemia, clinical case presentations, Pocatello, Idaho, September 27, 2005 Computerized Simulation for Training Delivery Room Resuscitation, Controversies in Neonatal-Perinatal Care Conference Series, University of Washington, April 22, 2005 Neonatal Hypoglycemia, clinical case presentation, Boise, Idaho, September 27, 2005 NeoSim Computer Simulation Program on CD for Teaching Neonatal Resuscitation, National Capital Area Medical Simulation Center, Bethesda, Md., May 14, 2005 Michael D. Neufeld, MD, MPH Neonatal Outcome and Follow-up of the High Risk Infant, pediatric Grand Rounds, Providence Everett Medical Center, Everett, Wash., 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Visiting professorships: Pocatello and Boise, Idaho Neonatology Case studies in neonatal respiratory care management, guest lecturer, Providence Everett Medical Center, Everett, Wash., 2005 Thomas P. Strandjord, MD Computerized Simulation for Training Delivery Room Resuscitation, Controversies in Neonatal-Perinatal Care Conference Series, University of Washington, April 22, 2005 Summer Seminar in Medical Ethics, University of Washington, August 5, 2005 Visiting professorship: Port Angeles, Wash. Peter Tarczy-Hornoch, MD Biomedical and Health Informatics (BHI), University of Washington School of Public Health and Community Medicine Strategic Leadership Retreat, Seattle, January 5, 2005 The Coming Convergence of Computing, Genomics, and Clinical Practice, Anesthesia Grand Rounds, University of Washington, February 16, 2005 Critical Thinking in Neonatology, Neonatal Nurse Practitioner CME, University of Washington, May 5, 2005 The Impact of Informatics on the Understanding and Treatment of Human Disease: Visions of the Future, moderator and organizing committee, 3rd Annual Frontiers in Biomedical Research Symposium, Seattle, May 23, 2005 PUBLICATIONS Bookstein FL, Connor PD, Covell KD, Barr HM, Gleason CA, Sze RW, McBroom JA, Streissguth AP. Preliminary evidence that prenatal alcohol damage may be visible in averaged ultrasound images of the neonatal human corpus callosum. Alcohol. 2005;36(3):151–160. Chabra C. Fetal and Neonatal Physiology, 3rd Edition (book review). Polin RA, Fox WW, Abman SH, eds. Arch Pediatr Adolesc Med. 2005;159(4):402. Chabra C, Gleason CA. Gastroschisis: embryology, pathogenesis, epidemiology. Neoreviews. 2005;6: e493–e499. Demers EJ, Juul SE. Erythropoietin neuroprotection in the term and preterm infant: safety and efficacy. In: Erythropoietin and the Nervous System. Hoke A, ed. Springer, 2005. Demers EJ, McPherson RJ, Juul SE. Erythropoietin protects dopaminergic neurons and improves neurobehavioral outcomes in juvenile rats after neonatal hypoxia-ischemia. Pediatr Res. 2005;58(2):297–301. Gleason CA, Back SA. Developmental physiology of the central nervous system. In: Avery’s Diseases of the Newborn, 8th Edition. Taeusch, Ballard, Gleason, eds. Elsevier Saunders, 2005. The Coming Convergence of Computing, Genomics, and Clinical Practice, Translational Medicine Meeting of Pacific Northwest Bio/Technologies Alliance, Seattle, September 22, 2005 Jackson JC. Atelectasis, Aspiration syndromes, Bronchopulmonary dysplasia, Diagnosis and management of air leaks, Persistent pulmonary hypertension of the newborn, Respiratory disease in the newborn, Respiratory distress syndrome (seven chapters). In: Pediatrics. Osborn LM, DeWitt TG, First LR, Zenel JA, eds. Elsevier Mosby, 2005. National Centers for Biomedical Computing: Informatics Enabling Biomedical Research, moderator and organizer, plenary panel, Fall 2005 AMIA Symposium, Washington, D.C., October 23, 2005 Juul SE. Developmental biology of the hematologic system. In: Avery’s Diseases of the Newborn, 8th Edition. Taeusch, Ballard, Gleason, eds. Elsevier Saunders, 2005. David E. Woodrum, MD IICU and NICU Ethics Conferences, University of Washington, 2005 Juul SE, Haynes JW, McPherson RJ. Evaluation of eosinophilia in hospitalized preterm infants. J Perinatol. 2005;25(3):182–188. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 165 Neonatology Loren DJ, Campos Y, d’Azzo A, Wyble L, Grange DK, Gilbert-Barness E, White FV, Hamvas A. Sialidosis presenting as severe nonimmune fetal hydrops is associated with two novel mutations in lysosomal alphaneuraminidase. J Perinatol. 2005;25(7):491–494. Loren DJ, Seeram NP, Schulman RN, Holtzman DM. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatr Res. 2005;57(6):858–864. McPherson RJ, Juul S. Patterns of thrombocytosis and thrombocytopenia in hospitalized neonates. J Perinatol. 2005;25(3):166–172. Mork P, Shaker R, Tarczy-Hornoch P. The multiple roles of ontologies in the biomediator data integration system. Data Integration in the Life Sciences: Second International Workshop Proceedings. LudГ¤scher B, Raschid L, eds. Lecture Notes in Computer Science. 2005;3615:96–104. Neufeld MD, Frigon C, Graham AS, Mueller BA. Maternal infection and risk of cerebral palsy in term and preterm infants. J Perinatol. 2005;25(2):108–113. Tarczy-Hornoch P. Evaluation of therapeutic recommendations, database management, and information retrieval. In: Avery’s Diseases of the Newborn, 8th Edition. Taeusch, Ballard, Gleason, eds. Elsevier Saunders, 2005. Tarczy-Hornoch P, Minie M. Bioinformatics challenges and opportunities. In: Medical Informatics: Knowledge Management and Data Mining in Biomedicine Series: Integrated Series in Information Systems. Chen, Fuller, Friedman, Hersch, eds. Springer, 2005. Wang K, Tarczy-Hornoch P, Shaker R, Mork P, Brinkley J. BioMediator data integration: beyond genomics to neuroscience data. AMIA Fall 2005 Symposium Proceedings 779–783. 166 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Nephrology The Division of Nephrology (in the Department of Pediatrics) provides specialized primary and consultative care for infants, children and adolescents with congenital and acquired renal problems. The division serves as the regional referral center for children with end-stage kidney disease and is a national leader in nephrology care. We have also increased our ability to provide outpatient care at outreach clinics in Washington, Alaska and Montana. The division runs a dialysis unit and also provides emergency dialysis and ongoing renal support to critically ill children in the intensive care units at Seattle Children’s Hospital. The need for dialysis services at Seattle Children’s continues to grow due to the increasing complexity of care for children undergoing cardiac surgery and transplants of bone marrow, heart and intestine. Division physicians evaluate children who are candidates for kidney transplantation; in conjunction with other members of a multidisciplinary transplant program, they manage the pre- and post-transplant care of renal transplant recipients. Our nephrology team of physicians, specialized nurses, dietitians and social workers provides a variety of support and follow-up services to ensure the best family-centered care. The nephrology research program at Seattle Children’s has become one of the largest and most productive programs in the country, and division faculty have received several competitive grants. We are committed to training physicians for careers in clinical and academic pediatric nephrology. Our fellowship program offers one of the most sought-after fellowships in the country, with the goal of producing leaders in the field of academic pediatric nephrology. Since 1990, we have trained 18 pediatric nephrologists; six more are currently in the program. Division members fulfill important educational roles in the community and continually participate in national organizations and societies; several faculty members hold leadership roles in these organizations. Division faculty are also frequent invited presenters at national and international meetings. TEACHING, RESEARCH AND CLINICAL EXPERTISE Allison A. Eddy, MD, is chief of the Division of Nephrology at Seattle Children’s Hospital and director of the pediatric nephrology fellowship program. She is professor of pediatrics at the University of Washington School of Medicine. Eight postdoctoral fellows — from FACULTY Allison A. Eddy MD, Chief Allison A. Eddy, MD, Chief Nicole R. Becker, MD Sangeeta R. Hingorani, MD, MPH JesГєs M. LГіpez-Guisa, PhD Ruth A. McDonald, MD Daryl M. Okamura, MD Jodi M. Smith, MD, MPH F. Bruder Stapleton, MD the USA, Japan, China and Korea — have trained in her laboratory. In addition to clinical work, she directs an active basic science research program and handles mentoring, training and administrative responsibilities. Dr. Eddy is internationally recognized for her work on the cellular and molecular basis of progressive kidney disease, and she is focused on two projects: One investigates the role of the urokinase receptor family in renal scarring Jordan M. Symons, MD and the other investigates Sandra L. Watkins, MD the role of scavenger Guoqiang Zhang, MD, PhD receptors in chronic kidney disease. Dr. Eddy co-directs the research training program in pediatric nephrology and is program director for the University of Washington Child Health Research Center. This SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 167 Nephrology program supports young pediatricians who have just completed clinical and basic science research training in any pediatric subspecialty area and who are ready to transition to their first clinician-scientist faculty position with ongoing research mentorship. Dr. Eddy is deputy editor of the Journal of the American Society of Nephrology and is an active member of the editorial board for the journal Pediatric Nephrology. Nicole R. Becker, MD, is attending physician at Seattle Children’s Hospital and associate clinical professor of pediatrics at the University of Washington School of Medicine. She received her MD from the University of Pennsylvania School of Medicine, Philadelphia. She completed a pediatrics residency and internship at Children’s Hospital of Philadelphia and a pediatric nephrology fellowship at Seattle Children’s. She also completed an adolescent medicine fellowship while working as an attending physician and assistant professor of pediatrics at Rush-Presbyterian–St. Luke’s Medical Center in Chicago. Dr. Becker cares for children in the Nephrology Clinic and is the nephrologist covering Mary Bridge Children’s Hospital in Tacoma, Wash. She is medical director at the Pierce County Juvenile Detention Center in Tacoma, where she provides adolescent medicine for incarcerated youth, as well as policy and management oversight for the medical department. She also works with the Pierce County Health Department and superior court judges on the Juvenile Court Executive Committee. Dr. Becker is working on a young adult patient transitioning plan in the Division of Nephrology and has a special interest in assuring that adolescents and their parents have normal life experiences, despite chronic illness, and successfully move into adulthood. Sangeeta R. Hingorani, MD, MPH, is attending physician at Seattle Children’s Hospital and assistant professor of pediatrics at the University of Washington School of Medicine. She received her MD from Albert Einstein College of Medicine. She did a pediatrics residency and a fellowship in pediatric nephrology at the University of Washington; she also earned her MPH from the university. Her clinical research program is investigating the pathophysiology of acute and chronic kidney disease after hematopoietic cell transplant. She has prospective studies ongoing at the Fred Hutchinson Cancer Research Center (FHCRC) to gain a better understanding of the timing and mechanisms of renal injury and to identify potential biomarkers for kidney 168 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON disease after stem cell transplant. Using the database at FHCRC, Dr. Hingorani conducted large epidemiologic studies to identify risk factors for both acute and chronic kidney disease after transplant and to evaluate the mortality associated with kidney injury in this patient population. Dr. Hingorani is co-chair of the Research Oversight Committee for the university pediatric nephrology fellowship program. She spends time teaching and mentoring fellows in both the clinical and clinical research arenas. She is also a member of the Pediatric Scientific Advisory Committee. JesГєs M. LГіpez-Guisa, PhD, is affiliated research assistant professor at the University of Washington School of Medicine and supervises fellows and research associates at the university. He earned his PhD in biochemistry at the University of WisconsinMadison. Dr. LГіpez-Guisa researches the mechanisms involved in the inflammatory and fibrotic mechanisms in progressive renal diseases. At Seattle Children’s he collaborated with the cardiology faculty on studies of thyroid metabolism and with the rheumatology faculty on the role of microchimerism in renal diseases. He maintains study collaborations outside of Seattle Children’s on the role of the IL-6 family of genes during kidney development and in normal and pathological conditions, and on the role of the IL-6 family of genes in osteoarthritis in a strain of mice he developed. Dr. LГіpez-Guisa is a member of several minority programs at the University of Washington and is a member of the American Association of Cancer Research and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) minority network. He has published numerous papers in peer-reviewed publications. Ruth A. McDonald, MD, is medical director of solid organ transplantation at Seattle Children’s Hospital and associate professor of pediatrics at the University of Washington School of Medicine. She also serves as co-director of several outreach clinics in pediatric nephrology in Washington, Alaska and Montana. She earned her MD at the University of Minnesota. She completed her residency and served as assistant chief resident, and completed a fellowship in the Division of Pediatric Nephrology at the University of Washington. She serves as principal investigator in many multicenter research studies on pediatric renal transplantation. She has a special clinical interest in post-transplant lymphoproliferative disorder and viral infections Nephrology after transplant in all solid organ transplant recipients. She is an at-large member of the Children’s University Medical Group Board of Directors and chairs the group’s Clinical Practice Committee. Dr. McDonald is well known and respected nationally as a leader in national organ allocation policy development, working actively in several organizations. She serves on the United Network for Organ Sharing (UNOS) Pediatric Committee and has been chair and vice chair; she is a member of other UNOS committees and serves on the board of directors. Daryl M. Okamura, MD, is attending physician at Seattle Children’s Hospital and acting instructor of pediatrics at the University of Washington School of Medicine. He completed his medical training and pediatrics residency at the University of Hawaii and completed his pediatric nephrology fellowship at Seattle Children’s. His clinical interests include the diagnosis and management of infants, children and adolescents with renal disease, particularly renal vasculitis, hypertension and chronic kidney disease. His research interests include the role of scavenger receptors and macrophages in the modulation of oxidative and inflammatory pathways in the progression of chronic kidney disease. Dr. Okamura has presented his research in many regional and national nephrology conferences and published several papers in peerreviewed journals. Jodi M. Smith, MD, MPH, is attending physician at Seattle Children’s Hospital and acting assistant professor of pediatrics at the University of Washington School of Medicine. She earned her MD and completed her pediatric residency at McGill University in Montreal. She completed a pediatric nephrology fellowship and earned an MPH in epidemiology from the University of Washington. She is studying the role of sub-clinical viral infections in the development of kidney transplant dysfunction in pediatric recipients. F. Bruder Stapleton, MD, is pediatrician-in-chief at Seattle Children’s Hospital; he is chairman of the Department of Pediatrics at the University of Washington School of Medicine and Ford Morgan Endowed Chair. He was chief of the Division of Pediatric Nephrology at the University of Tennessee, where he founded the pediatric General Clinical Research Center. He served as A. Conger Goodyear Chair of the Department of Pediatrics and pediatri- cian-in-chief and medical director for Children’s Hospital of Buffalo in New York. He has served as secretary-treasurer and president of the American Society of Pediatric Nephrology, assistant secretarygeneral and treasurer of the International Pediatric Nephrology Association, president of the Southern Society for Pediatric Research, chairman of the Sub-Board of Pediatric Nephrology of the American Board of Pediatrics and a member of its Board of Directors and a member of the Council of Pediatric Research for the American Academy of Pediatrics. He is on the Executive Council of the American Pediatric Society and is the founding editor-in-chief of Journal Watch Pediatrics and Adolescent Medicine. He is president of the Association of Medical School Pediatric Department Chairs and head of the Data Safety Monitoring Board for the NIH National Study of Kidney Disease in Children. Jordan M. Symons, MD, is attending physician at Seattle Children’s Hospital and associate professor of pediatrics at the University of Washington School of Medicine. He is medical director of dialysis at Seattle Children’s and he treats general nephrology, kidney transplant and dialysis patients. He received his MD from Columbia University College of Physicians and Surgeons. He completed a pediatrics residency at Children’s Memorial Hospital in Chicago and pediatric nephrology training at Children’s Hospital Boston. Dr. Symons has a primary interest in the care and treatment of acute kidney injury in critically ill patients; he is a founding member of the Prospective Pediatric Continuous Renal Replacement Therapy Registry, a pediatric multicenter consortium engaged in cooperative study of CRRT methods. Dr. Symons also has a strong interest in medical education; he is a member of the College Faculty of the University of Washington School of Medicine, a group of 30 medical faculty dedicated to the development and implementation of a four-year integrated curriculum of clinical skills and professionalism. He instructs and mentors approximately 25 medical students per year. Sandra L. Watkins, MD, is director of clinical nephrology at Seattle Children’s Hospital and professor of pediatrics at the University of Washington School of Medicine. She is co-associate program director of the Pediatric Satellite of the clinical Research Center at the University of Washington. She serves as president of the American Society of Pediatric Nephrology. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 169 Nephrology She is a past board member of the Renal Physicians Association and a member of the Northwest Renal Networks Medical Review Board. Her clinical interests include the full breadth and depth of pediatric renal disease and hypertension. Her research interests include end-stage renal disease therapies and glomerulonephritis. She is principal investigator for the Focal Segmental Glomerulosclerosis Clinical Trial, a multicenter interventional trial. She has been listed as one of Seattle’s top doctors for several years. RESEARCH FUNDING Guoqiang Zhang, MD, PhD, is senior scientist at Seattle Children’s Hospital. He received two years of postdoctoral training at Sheffield Kidney Institute, University of Sheffield, UK. Dr. Zhang’s research at the University of Washington has focused on the molecular mechanisms of chronic renal injury, in particular the control of renal myofibroblast activation. His studies have led to the finding of an alternative urokinase fibroblast receptor. The pathological function of this newly identified urokinase receptor in the progression of kidney disease is being studied intensively. Dr. Zhang is actively seeking to expand this research and his goal is to bring these studies to the bedside to benefit kidney patients. Dr. Zhang has served as manuscript reviewer for Experimental Nephrology (London) and Journal of the American Society of Nephrology. He has supervised visiting research fellows, research associates and summer students. Sandra L. Watkins, MD Pediatric Nephrology Research Training Program, NIDDK/NIH, $251,337 AWARDS AND HONORS Renal Injury After Hematopoietic Stem Cell Transplant, National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS, $152,820 Daryl M. Okamura, MD Research Trainee Award, American Society of Pediatric Nephrology, 2005 F. Bruder Stapleton, MD Listed in “Best Doctors in America,” 2005 One of America’s Top Pediatricians, Consumers’ Research Council of America, 2005 Guoqiang Zhang, MD, PhD Young Investigator Award, Seattle Children’s Hospital, 2005 Sandra L. Watkins, MD Listed in “Best Doctors 2005,” Seattle magazine 170 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON New Jodi M. Smith, MD, MPH Renal Transplant and Subclinical Herpesvirus Infection, National Kidney Foundation, $50,000 Renal Transplant and Subclinical Herpesvirus Infection, National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS, $127,845 Continuing Allison A. Eddy, MD Fibrotic Sequelae of Childhood Renal Disease, Vanderbilt University, National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS, $154,081 Molecular Mechanisms in Renal Interstitial Fibrosis, National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS, $364,250 Sangeeta R. Hingorani, MD, MPH Renal Injury After Hematopoietic Stem Cell Transplant, American Society of Nephrology, $200,000 Jodi M. Smith, MD, MPH Chronic Allograft Nephropathy: The Role of Subclinical Herpesvirus Infection, American Society of Transplantation, $80,000 Ruth A. McDonald, MD B7 Costimulatory Blockade in Pediatric Transplantation, Children’s Hospital Boston, National Institute of Allergy and Infectious Diseases/NIH/ DHHS, $91,706 Sandra L. Watkins, MD Focal-Segmental Glomerulosclerosis in Young Patients, National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS, $372,729 Nephrology Pathophysiology of Childhood Hemolytic Uremic Syndrome, Washington University of St. Louis, National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS, $188,099 Sangeeta R. Hingorani, MD, MPH Research in Progress: The Kidney After Hematopoietic Cell Transplant, renal Grand Rounds, Northwest Kidney Center, Seattle, June 17, 2005 TEACHING AND PRESENTATIONS Ruth A. McDonald, MD Renal Allograft Allocation in Children, KARS meeting, Chicago, January, 13, 2005 Allison A. Eddy, MD The Destruction of a Kidney: Scenes from the Battlefield, renal Grand Rounds, University of Pennsylvania, January 2005 Update on the Transplant Registry, 2004, NAPRTCS annual meeting, Las Vegas, January 14, 2005 The Destruction of a Kidney: Scenes from the Battlefield, AMSPDC/Frontiers in Science Meeting, Kiawah Island, S.C., March 2005 Normal and Fibrotic Renal Structure and Architecture, National Institute of Diabetes and Digestive and Kidney Diseases, fibrosis imaging workshop, April 2005 Management Issues in the Child with Chronic Kidney Disease, World Congress of Nephrology pediatric nephrology workshop, Singapore, June 2005 Proteinuria as Mediator of Chronic Kidney Disease, World Congress of Nephrology, Singapore, June 2005 Proteinuria as Mediator of Chronic Kidney Disease, Western Regional Pediatric Nephrology meeting, Honolulu, July 2005 The Destruction of a Kidney: Scenes from the Battlefield, renal Grand Rounds, University of Alberta, Edmonton, October 2005 Proteinuria, Lipids and Interstitial Fibrosis, American Society of Nephrology Renal Week Symposium, Why Kidneys Fail: Translating Basic Mechanisms of Disease into Novel Therapies. Philadelphia, November 2005 Mechanisms of Kidney Destruction, Biogen Idec Seminar: Novel Targets and Pathways in Tissue Fibrosis. Cambridge, Mass., November 2005 Childhood Nephrotic Syndrome 2005: Destruction of a Kidney: Scenes from the Battlefield, visiting professor lecture, University of Texas Southwestern University, Dallas, May 2005 Management of the Sensitized Transplant Recipient, Dialysis Annual Conference, Tampa, Fla., March 2, 2005 Chronic Renal Insufficiency and Failure, Genentech training seminar, San Francisco, March 4, 2005 Extended Donor Criteria and the Pediatric Recipient: How to Optimize the Deceased Donor List for the Benefit of Our Patients, American Society of Pediatric Nephrology annual meeting, Washington, D.C., May 15, 2005 Optimizing Living Donor Transplantation in Children, American Transplant Congress, pediatric symposium, Seattle, May 21, 2005 Update NAPRTCS Transplant Registry, 3rd Congress of IPTA, Innsbruck, Austria, August, 7, 2005 Daryl M. Okamura, MD Role of CD36 in Progressive Renal Fibrosis, Vanderbilt Research Conference, Nashville, Tenn., February 9, 2005 Management of Hypertensive Emergencies in Children, University of Hawaii Pediatric Resident Teaching Conference, Honolulu, July 26, 2005 Multifunctional Role of CD36 in Progressive Renal Fibrosis, University of Hawaii Pediatric Resident Teaching Conference, Honolulu, July 27, 2005 F. Bruder Stapleton, MD How many pediatricians are needed for the future?, Grand Rounds, University of Florida, Jacksonville. Jan 17–18, 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 171 Nephrology Quantitative measures of a healthy pediatric department, Association of Pediatric Department Chairs annual meeting, Kiawah Island, S.C., March 9, 2005 Meet the Professor — Careers on Pediatric Nephrology, Pediatric Academic Societies annual meeting, Washington, D.C., May 15, 2005 Diet and Kidney Stones: Good News/Bad News; Acute Urate Nephropathy; and Genetics of Urolithiasis: The Picture Grows More Confusing, VII Congress of the Association of Latin American Pediatric Nephrologists. San Jose, Costa Rica, November 5–8, 2005 Jordan M. Symons, MD Pediatric CRRT: The Basics and Controversies in Pediatric CRRT, Tenth International Conference on Continuous Renal Replacement Therapy, San Diego, March 2005 Proteinuria in Pediatric Patients, 19th Annual A Day in the Office: Problems in Pediatric Practice, Group Health Cooperative Continuing Medical Education Program, Seattle, April 2005 Sandra L. Watkins, MD Complications of Dialysis in Children, Pediatric Nephrology Seminar XXXII, Miami, February 26, 2005 PUBLICATIONS Ake JA, Jelacic S, Ciol MA, Watkins SL, Murray KF, Christie DL, Klein EJ, Tarr PI. Relative nephroprotection during Escherichia coli O157:H7 infections: association with intravenous volume expansion. Pediatrics. 2005;115:e673–e80. Andreoli S, Brewer E, Watkins SL, Fivush B, Powe N, Shevchek J, Foreman J. American Society of Pediatric Nephrology position paper on linking reimbursement to quality of care. J Am Soc Nephrol. 2005;16:2263–2269. Brophy PD, Somers MJG, Baum MA, Symons JM, McAfee N, Fortenberry JD, Rogers K, Barnett J, Blowey D, Baker C, Bunchman TE, Goldstein SL. Multi-centre evaluation of anticoagulation in patients receiving continuous renal replacement therapy (CRRT). Nephrol, Dialy, and Transplant. 2005;20:1416–1421. CCTPT Study Group (Benfield MR, Tejani A, Harmon WE, McDonald RA, Stablein DM, McIntosh M, Rose S). A randomized multicenter trial of OKT3 mAbs induction compared with intravenous cyclosporine in pediatric renal transplantation. Pediatr Transplant. 2005;9:282–292. Common Complications of Dialysis in Children, Fundamentals of Dialysis in Children, Tampa, Fla., February 27, 2005 Debley JS, Smith JM, Redding GW, Critchlow CJ. Childhood asthma hospitalization risk after cesarean delivery in former term and premature infants. Ann Allergy Asthma Immunol. 2005;94:228–233. FSGS NIH Study: An Approach to Multicenter Trials, Pediatric Nephrology Seminar XXXIII, Miami, March 11, 2005 Eddy AA. Can renal fibrosis be reversed? (invited editorial commentary). Pediatr Nephrol. 2005;20:1369–1375. Eddy AA. Progression in chronic kidney disease. Adv Chronic Kidney Dis. 2005;12:353–365. Gillespie RS, Symons JM. Sodium ferric gluconate for post-transplant anemia in pediatric and young adult renal transplant recipients. Pediatr Transplant. 2005;9:43–46. 172 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Nephrology Goldstein SL, Somers MJG, Baum MA, Symons JM, Brophy PD, Blowey DL, Bunchman TE, Baker C, Mottes T, McAfee N, Barnett J, Morrison G, Rogers K, Fortenberry J. Pediatric patients with multi-organ dysfunction syndrome receiving continuous renal replacement therapy. Kidney International. 2005;67:653–658. McClure TD, Young ME, Taegtmeyer H, Ning X, Buroker NE, LГіpez-Guisa J, Portman MA. Thyroid hormone interacts with PPAR{alpha} and PGC-1 during mitochondrial maturation in sheep heart. American Journal of Physiology: Heart and Circulation Physiology. Nov 2005;289:H2258–H2264. Gordon C, Stapleton FB. Hematuria in adolescents. In: Adolescent Medicine Clinics: Nephrologic Disorders in the Adolescent. Sherwinter J, Foulds DM, Greydanus DE, eds. Philadelphia: Elsevier Sanders, 2005;16: 229–239. Neu AM, Bedinger M, Fivush BA, Warady BA, Watkins SL, Friedman AL, Brem AS, Goldstein SL, Frankenfield DL. Growth in adolescent hemodialysis patients — longitudinal data from the Centers for Medicare & Medicaid Services end-stage renal disease clinical performance measures project. Pediatr Nephrol. 2005;20:1156–1160. Gorman G, Fivush B, Frankenfield D, Warady B, Watkins S, Brem A, Neu A. Short stature and growth hormone use in pediatric hemodialysis patients. Pediatr Nephrol. 2005;20:1794–1800. Gross TG, Bucuvalas JC, Park JR, Greiner TC, Hinrich SH, Kaufman SS, Langnas AN, McDonald RA, Ryckman FC, Shaw BW, Sudan DL, Lynch JC. Low-dose chemotherapy for Epstein-Barr virus-positive post-transplantation lymphoproliferative disease in children after solid organ transplantation. J Clin Oncol. 2005;23:6481–6488. Harmon WE, McDonald RA, Reyes JD, Bridges ND, Sweet SC, Sommers CM, Guidinger MK. Pediatric transplantation, 1994–2003. Am J Transpl. 2005; 887–903. Hingorani SR, Guthrie KA, Batchelder AL, Aboulhosn N, Schoch HG, McDonald GB. Acute renal failure after myeloablative hematopoietic cell transplant: incidence and risk factors. Kidney International. 2005;67:272–277. Matsuo S, LГіpez-Guisa JM, Cai X, Okamura DM, Alpers CE, Bumgarner RE, Peters MA, Zhang G, Eddy AA. Multi-functionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1 over-expressing mice. Kidney International. 2005;67:2221–2238. Rivara FP, Stapleton FB. Closing the quality chasm in health care — the role of critical reading. Arch Ped Adol Med. 2005;159:39. Smith JM, McDonald RA. Renal transplantation in adolescents. In: Adolescent Medicine Clinics: Nephrologic Disorders in the Adolescent. Sherwinter J, Foulds DM, Greydanus DE, eds. Philadelphia: Elsevier Sanders, 2005;(16):201–214. Stapleton FB. Asymptomatic microscopic hematuria: time to look the other way? Arch Ped Adol Med. 2005;159:398–399. Stapleton FB, Jones D, Fiser D. Leadership trends in academic pediatric departments. Pediatrics. 2005;116:342–344. Stapleton FB, Pendergrass TP. A new approach to the departmental faculty meeting. J Pediatr. 2005;146:155–156. Symons J, Grady R. Disorders of the genitourinary system in the newborn. In: Pediatrics. Osborn, DeWitt, First, Zenel, eds., Philadelphia: Elsevier Mosby, 2005. Stapleton FB. Acute urate nephropathy. In: Primer on Kidney Disease, 4th Edition. Greenberg A, ed. National Kidney Foundation, 2005;301–304. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 173 Pulmonary Medicine The Division of Pulmonary Medicine (in the Department of Pediatrics) devotes its time and resources to improvement in diagnosis, care and outcomes of children with acute and chronic respiratory disease. It provides comprehensive and innovative care for infants and children in the WAMI region (Washington, Alaska, Montana, Idaho) through outreach clinics and regional training. The division has 11 pediatric pulmonologists and 30 health care support staff in multiple disciplines. It provided clinical care to 4,746 children in 2005. The division includes nationally recognized programs and experts in cystic fibrosis (CF), scoliosis, asthma and sleep medicine. It comprises interdisciplinary health care teams of physicians, nurses, social workers, nutritionists and respiratory therapists. The teams provide comprehensive coordinated care to children with chronic breathing difficulties and children dependent on respiratory support technology at home. The teams promote coordinated disease management, emphasizing family and patient education, self-management, long-term planning and psychosocial well-being. The University of Washington has a rich clinical and research foundation in CF, and we are fortunate to be aligned with a CF Research Development Program and a Core Center for Gene Therapy. The Cystic Fibrosis Center has affiliate programs in Tacoma and Spokane, Wash. and in Anchorage, Alaska. The division provides and develops innovative diagnostic techniques, management strategies and outcome tracking systems for children with respiratory concerns. Our pulmonary diagnostic services include function testing designed specifically for infants and for older children, flexible bronchoscopy, complete imaging resources, quantitative microbiology, exhaled breath analyses and formal polysomnography and cognitive evaluations for pediatric sleep disorders. The division maintains a nationally accredited pulmonary fellowship training program. It also conducts molecular, clinical and outcomes research and has amassed an impressive record of research contributions in various areas of pediatric pulmonary medicine over the last two decades. TEACHING, RESEARCH AND CLINICAL EXPERTISE Gregory J. Redding, MD, is chief of the Division of Pulmonary Medicine at Seattle Children’s Hospital. He is professor of pediatrics and director of the Pediatric Pulmonary Training Center grant. He earned his MD from Stanford University. He completed a pediatrics residency at Harbor General/UCLA and a pediatric pulmonary fellowship at the University of Colorado. Dr. Redding is committed to improvement in children’s health and health care through research, training, advocacy, clinical excellence and improvement in systems of health care. Dr. Redding is an internationally recognized expert and leader in pediatric pulmonary medicine. His clinical scope is broad, and he is specifically interested in children with chest wall and spine deformities, interstitial lung diseases 174 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON and asthma. He also specializes in chronic respiratory disorders among Third World populations of children. Dr. Redding’s research interests include the pathogenesis of chronic lung disease in developing countries, disorders of the thoracic cage and their treatments and interstitial lung disease in children. His training philosophy is to assure independent and critical thinking and the application of physiologic principles to clinical problems. He is a consultant to the Maternal–Child Health Bureau on leadership training in multiple health care professions. Edward R. Carter, MD, is chief of the Asthma Center at Seattle Children’s Hospital. He earned his MD from Vanderbilt University Medical School and completed a residency in pediatrics at Walter Reed Army Medical Center. He completed pediatric pulmonary training Pulmonary Medicine at the University of Florida, Gainesville. At Madigan Army Medical Center in Tacoma, Wash. he became chief of pediatric pulmonology and then chief of the department of pediatrics. He retired from the Army with the rank of colonel. Dr. Carter is committed to making the pulmonary division accessible to both patients and primary care providers. He co-edited the Department of Defense–Veteran’s Administration guidelines for the management of asthma. This guideline was implemented worldwide in federal health facilities. His clinical interests are asthma, the management of the respiratory complications of neuromuscular disorders and home mechanical ventilator support. He is also active in the management of children with cystic fibrosis. Dr. Carter’s research interests include clinical asthma management, asthma follow-up and medical adherence, and assessment of new pulmonary function techniques in toddlers and young children. Maida L. Chen, MD, is associate director of the Pediatric Sleep Center and attending physician at Seattle Children’s Hospital and acting assistant professor in the Department of Pediatrics at the University of Washington School of Medicine. Her clinical interests center on sleep disorders in infants, children and adolescents. Her research interests focus on respiratory control disorders and sleep-disordered breathing. Jason S. Debley, MD, MPH, is chief of the bronchoscopy service at Seattle Children’s Hospital. He received his medical degree from Northwestern University Medical School, Chicago. He completed his pediatrics internship and residency at Children’s Memorial Hospital in Chicago. He spent one year as chief resident followed by a year as staff pediatric hospitalist at Emanuel Children’s Hospital in Portland, Ore. He completed his FACULTY Gregory J. Redding MD, Chief Gregory J. Redding, MD, Chief Edward R. Carter, MD Maida L. Chen, MD Jason S. Debley, MD, MPH Julia C. Emerson, MD, MPH Ronald L. Gibson, MD, PhD Nicole Mayer Hamblett, PhD Lucas R. Hoffman, MD, PhD Yemiserach Kifle, MD Susan G. Marshall, MD pediatric pulmonary fellowship at Seattle Children’s and also earned an MPH from the University of Washington. Dr. Debley has expertise in asthma, cystic fibrosis, bronchopulmonary dysplasia, management of acute and chronic respiratory failure, restrictive lung diseases of childhood and flexible bronchoscopy. He is director of pediatric flexible fiber optic bronchoscopy at Seattle Children’s. His research interests include recurrent wheezing of early childhood, asthma epidemiology and non-invasive measures of airflow obstruction and airway inflammation in young children. Dr. Debley is committed to expanding clinical pulmonary services at Seattle Children’s and establishing a sound pediatric asthma research base. He is also extremely involved with medical student, resident and fellow training. Julia C. Emerson, MD, MPH, is epidemiologist at Seattle Children’s Hospital and lecturer in pediatrics at the University of Washington School of Medicine. Dr. Emerson’s research interests include the natural history of early cystic fibrosis (CF) lung disease, the design of clinical trials to improve CF therapies and the development of better outcome measures for CF clinical protocols. She also collaborates on studies of the genotypic and phenotypic changes in airway pathogens that may be associated with CF lung disease severity and progression. Ronald L. Gibson, MD, PhD, is co-director of the pediatric pulmonary fellowship program and director of the Cystic Fibrosis Center at Seattle Children’s Hospital. He attended Washington University in St. Louis for his graduate degrees and completed pediatrics residency training and a fellowship in pediatric pulmonology at the University of Washington School of Medicine. Dr. Gibson is committed to excellent, multidisciplinary patient care, small group teaching and research. His primary research Samuel M. Moskowitz, MD Bonnie W. Ramsey, MD focus is on Pseudomonas Margaret Rosenfeld, MD, MPH aeruginosa airway infections in young children with cystic fibrosis (CF). As a member of the Cystic Fibrosis Therapeutic Development Network, he has been principal investigator or co-investigator for several Phase I SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 175 Pulmonary Medicine and Phase II clinical trials involving novel antimicrobial agents, anti-inflammatory compounds, gene therapy and modulators of ion transport. He also collaborates with divisional colleagues and faculty on single-center CF research studies. Nicole Mayer Hamblett, PhD, is research assistant professor in the Division of Pulmonary Medicine at Seattle Children’s Hospital and in the Department of Pediatrics at the University of Washington School of Medicine. She is biostatistician and associate director of statistics at the Cystic Fibrosis Therapeutics Development Network Coordinating Center based at Seattle Children’s. Her research interests include the design and analysis of clinical trials, with emphasis in the pediatric and orphan disease settings. She is also involved in the statistical training of clinical researchers and scientists, with applications to both the laboratory and clinical fields. Lucas R. Hoffman, MD, PhD, is attending physician at Seattle Children’s Hospital. He earned his MD and a PhD in biochemistry at the University of California, San Francisco. He did his pediatrics internship and residency at the University of Washington and Seattle Children’s and completed training in pediatric pulmonology at the university. Dr. Hoffman’s research interests are centered on chronic lung infections. He is investigating the bacteria associated with lung infections in patients with cystic fibrosis (CF). While the past century has seen remarkable advances in fighting acute and devastating infections due to the advent of antibiotics, chronic infections have proven to be extremely difficult to treat due to their poor response to these antibiotics. Dr. Hoffman’s research aims for a better understanding of how these infectious organisms evade killing by these powerful medications. This information should enable the design of better medical regimens to combat chronic infections. Dr. Hoffman also cares for patients and teaches medical students, residents and fellows. His areas of clinical expertise include asthma, CF, bronchopulmonary dysplasia, restrictive lung diseases and the pulmonary complications of neuromuscular disease. Yemiserach Kifle, MD, is clinical director of the sleep program in the Division of Pulmonary Medicine at Seattle Children’s Hospital. She obtained her MD from Addis Ababa University, Ethiopia and completed her 176 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON pediatric residency at SUNY Health Sciences Center, Children’s Hospital Brooklyn. She did her pulmonary fellowship at the University of Florida. Dr. Kifle is board certified in pediatrics, pediatric pulmonology and sleep medicine. She has been instrumental in establishing a comprehensive and fully accredited pediatric sleep center at Children’s Hospital. Her clinical interests are obstructive sleep apnea and sleep behavioral issues. Susan G. Marshall, MD, is attending physician at Seattle Children’s Hospital and associate dean for curriculum at the University of Washington School of Medicine. She earned her MD at the University of California, Los Angeles. She completed her pediatric residency and fellowship at the University of Washington. She participates in the Division of Pulmonary Medicine’s weekly Chest Clinic. Dr. Marshall is especially involved with patients suffering from neuromuscular disease, cystic fibrosis and psychosocial problems. At the School of Medicine, she is involved in teaching, educational planning and curriculum development. In the pulmonary division she works with medical students, residents, fellows and faculty. Samuel M. Moskowitz, MD, is attending physician at Seattle Children’s Hospital. He earned his MD from the Harvard University Medical School; he did a pediatrics residency and a fellowship in pediatric pulmonology at the University of Washington School of Medicine. His research and clinical interests center on cystic fibrosis (CF). He devotes much of his time to research into the molecular biology of Pseudomonas bacteria, specifically looking at mechanisms of infection and resistance of this organism. His research includes the study of antibiotic and antimicrobial peptide resistance of P. aeruginosa, comparative microbiology of lung infection in CF and other chronic pulmonary disorders and microbiological and genetic correlates of CF lung disease severity. His educational interests include training medical students and residents in pediatric pulmonary medicine, and career mentorship of pediatrics residents and subspecialty fellows. Bonnie W. Ramsey, MD, is attending physician and co-director of the Pediatric General Clinical Research Center at Seattle Children’s Hospital. She holds the Bonnie Ramsey Endowed Chair in Cystic Fibrosis Research at the University of Washington School of Pulmonary Medicine Medicine. She earned her MD from Harvard Medical School and completed her residency in pediatrics at Children’s Hospital Boston and Seattle Children’s Hospital. Dr. Ramsey has been part of the Seattle Children’s team for more than 25 years and is internationally recognized as a premier clinical investigator in cystic fibrosis (CF). She was lead investigator of the TOBIв„ў (Tobramycin Solution for Inhalation) clinical trials. She has authored numerous articles and book chapters on CF and respiratory care, and has regularly presented her research to the American Thoracic Society Physicians and Cystic Fibrosis Foundation; she is frequently invited to speak internationally. Dr. Ramsey has served on two Institute of Medicine committees reviewing guidelines for participant safety in clinical research.. She is a member of the American Pediatric Society and the American Association of Physicians. Dr. Ramsey is also director of a clinical trials network — the Cystic Fibrosis Therapeutics Development Network — which consists of 18 academic sites in the US with the coordinating center at Seattle Children’s. Margaret Rosenfeld, MD, MPH, is medical director of the pulmonary function laboratory at Seattle Children’s Hospital and associate professor of pediatrics at the University of Washington School of Medicine. Her clinical interests focus on the diagnosis and management of respiratory illnesses in children of all ages. Her research program focuses on the assessment and treatment of early cystic fibrosis (CF) lung disease, including infant lung function tests and an investigation of risk factors for early acquisition of Pseudomonas aeruginosa. She is co-fellowship coordinator for the university Department of Pediatrics and serves as CF consultant to the Washington State Newborn Screening Program. AWARDS AND HONORS Maida L. Chen, MD Best Poster Award, Saban Research Institute, Children’s Hospital Los Angeles Ching-I Wong Research Award for Outstanding Research in Pediatric Pulmonology, Children’s Hospital Los Angeles Ronald L. Gibson, MD, PhD Listed in “Best Doctors 2005,” Seattle magazine Listed in “Best Doctors in America,” 2005 Lucas R. Hoffman, MD, PhD Leroy Matthews Physician Scientist Award First author of one of 2005’s “Top Articles in Infectious Disease,” Pediatric News Samuel M. Moskowitz, MD Young Investigator Award, General Clinical Research Center, University of Washington School of Medicine Bonnie W. Ramsey, MD National Library of Medicine Women of Distinction Gregory J. Redding, MD Listed in “Best Doctors in America,” 2005 Listed in “Best Doctors 2005,” Seattle magazine Family Experience Survey Award Winner, Seattle Children’s Division of Pulmonary Medicine RESEARCH FUNDING New Jason S. Debley, MD, MPH Noninvasive Measures in Wheezy Infants and Toddlers, National Heart, Lung, and Blood Institute/ NIH/DHHS, $126,645 Lucas R. Hoffman, MD, PhD Antibiotic-Mediated Adaptation of Pseudomonas aeruginosa, NIAID/NIH, $126,306 Yemiserach Kifle, MD Pediatric Pulmonary Training Center, University of Washington, Health Resources and Services Administration/DHHS, $67,008 Samuel M. Moskowitz, MD Polymyxin Pseudomonas in CF Lung Infection, Cystic Fibrosis Foundation, $75,000 Bonnie Ramsey, MD General Clinical Research Center-Pediatric Satellite, University of Washington, National Institutes of Health/DHHS, $894,859 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 177 Pulmonary Medicine Therapeutic Development Network Coordinating Center, University of Washington, National Center for Research Resources/NIH/DHHS, $813,473 P. Aeruginosa as a Surrogate Marker of Cystic Fibrosis, University of Washington, National Institute of Diabetes and Digestive and Kidney Diseases/NIH/ DHHS, $59,022 A Phase I Safety and Dose-Finding Study of Orally Administered Curcuminoids in Adult Subjects with Cystic Fibrosis Who Are Homozygous for Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (F508 CFTR) Mutation, SEER Pharmaceuticals, Inc., $396,712 General Services Agreement Task Order No. 4: Natural History of Progressive CF Lung Disease Utilizing Controlled Volumetric Lung CT Imaging, Pulmonary Function Measurements, Sputum Indices, and Clinical Scores in Children with Mild CF Lung Disease – Proto, Novartis Pharmaceuticals Corporation, $57,714 A Phase 2 Study of PTC124 as an Oral Treatment for Nonsense-Mutation-Mediated Cystic Fibrosis, PTC Therapeutics, Inc., $234,525 Gregory J. Redding, MD Pediatric Pulmonary Leadership Training Center, HRSA/MCHB, $366,000 Continuing Ronald L. Gibson, MD, PhD Cystic Fibrosis Centers, Cystic Fibrosis Foundation, $97,650 Lucas R. Hoffman, MD, PhD Adaptation to the CF, Cystic Fibrosis Foundation, $67,500 Samuel M. Moskowitz, MD Host-Pathogen Interactions in Cystic Fibrosis, NHLBI/NIH, $125,658 Influence of ENaC Regulators on CF Lung Severity, NHLBI/NIH, $185,048 178 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Bonnie W. Ramsey, MD MTCC Human Core, NIDDK/NIH, $163,895 CHRMC Administrative and Clinical Cores — Molecular Biology in CF, University of Washington, Cystic Fibrosis Foundation, $57,522 Duration of Antimicrobial Treatment Effect Following Administration of Tobramycin Solution for Inhalation (TOBI) in Young Children with Cystic Fibrosis, Chiron Corp., $940,848 Inhaled Tobramycin in Young Cystic Fibrosis Patients, National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS, $702,749 A Multicenter, Double-Blind, Placebo-Controlled, Phase 2 Study of Aerosolized tgAAVCF for the Treatment of Cystic Fibrosis, Targeted Genetics Corporation, Cystic Fibrosis Foundation, $2,231,299 Core Center for Gene Therapy: Administrative and Human Cores, University of Washington, National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS, $125,456 Therapeutics Development Network — Coordinating Center, Cystic Fibrosis Foundation, $2,800,036 CP-AI-003 A Blinded, Multicenter, Randomized, Placebo-Controlled Trial with Aztreonam for Inhalation (AI) in Cystic Fibrosis, Salus Pharma, Inc., $1,008,984 Long-Term Safety and Efficacy of Azithromycin in CF: Observational Study of AZ0001 Participants, Cystic Fibrosis Foundation, $662,138 Efficacy and Safety of Intermittent Antimicrobial Therapy for the Treatment of New Onset Pseudomonas Aeruginosa Airway Infection in Young Patients with Cystic Fibrosis (Early Antipseudomonal Therapy in CF), Cystic Fibrosis Foundation, $1,131,388 Early Antipseudomonal Therapy in Cystic Fibrosis, National Heart, Lung, and Blood, Institute/NIH/ DHHS, $1,388,177 Pulmonary Medicine Assessment of Induced Sputum as a Tool to Evaluate Anti-Inflammatory Agents in Patients with Cystic Fibrosis, Cystic Fibrosis Foundation, $2,011,287 A Phase 2, Randomized, Double-Blind, ParallelDose Ranging Study of Oral TheraCLEC-Total in Cystic Fibrosis Subjects with Exocrine Pancreatic Insufficiency, Altus Pharmaceuticals, Inc., $232,867 Margaret Rosenfeld, MD Mentored Patient-Oriented Research Career Development Award, NCRR/NIH, $69,796 Evaluation of Pulmonary Function Tests from Raised Lung Volumes as Outcome Measures for Clinical Trials in Infants with Cystic Fibrosis, Cystic Fibrosis Foundation, $328,040 EPIC Observational Study, Cystic Fibrosis Foundation, $385,805 TEACHING AND PRESENTATIONS Edward R. Carter, MD Management of the Wheezing Infant, plenary session, Contemporary Forums Regional Nursing Program, Seattle, March 2005 Pediatric Pulmonary Peals, and William Osler: His Legacy to Pediatrics and Medical Education, workshops, Madigan Army Medical Center Annual Regional Military Pediatric Conference, Tacoma, Wash., October 2005 Epidemiology of Asthma, plenary session, Annual Northwest Regional Respiratory Therapy Conference, Seattle, October 2005 Inpatient Bronchiolitis, Grand Rounds, Seattle Children’s, November 2005 Evaluation of the Wheezy Infant: Management of Empyema, Bellingham, Wash., February 2005 Jason S. Debley, MD, MPH Chronic Lung Disease of Prematurity, University of Washington School of Nursing, May 2005 Asthma Update, Port Angeles, Wash., November 2005 Analysis of Exhaled Breath in Pulmonary Disease: Exhaled Nitric Oxide and Biomarkers in Breath Condensate as Clinical and Research Tools, Grand Rounds, Seattle Children’s, December 2005 Ronald L. Gibson, MD, PhD Cystic Fibrosis — Research Update and Sharing of Center-Specific Data, CF Parent’s Day — Educational Conference, Seattle, March 2005 Hypertonic Saline in Cystic Fibrosis, quarterly regional CF conference, Seattle, April 2005 Biomarkers of Early CF Lung Disease, Surrogate Biomarkers Summit at CF Foundation, Bethesda, Md., January 2005 Early Intervention in CF Lung Disease, North American CF Conference, Baltimore, October 2005 Inhaled Tobramycin in Young Children with CF, American Thoracic Society meeting, San Diego, May 2005 Samuel M. Moskowitz, MD Diverse Mutational Events in Polymyxin-Resistant Pseudomonas Aeruginosa from Colistin-Treated Cystic Fibrosis Patients Are Associated with a Common Pattern of Lipid A Modification, poster presentation, ASCI/AAP joint meeting, Chicago, April 2005 Polymyxin-Resistant Pseudomonas from Cystic Fibrosis Patients: Specific Lipid A Changes Associated with Diverse Mutational Events, UCLA School of Medicine, June 2005 Colistin-Treated Cystic Fibrosis Patients Harbor Polymyxin-Resistant Strains of Pseudomonas Aeruginosa, Some with Mutation of PmrAB, a TwoComponent Regulator of Lipid A Structure poster presentation and Microbiology and Infectious Diseases Workshop co-moderator, North American CF Conference, Baltimore, October 2005 Bonnie W. Ramsey, MD Development of New Antimicrobial Therapies: How Can the CF Community Successfully Partner with Industry and FDA?, CFF Antimicrobial Taskforce, Bethesda, Md., 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 179 Pulmonary Medicine CF Care Centers and Quality Improvement, CF Parents Day, Seattle Children’s, March 2005 Cystic Fibrosis Part 2, noon housestaff lecture, Seattle Children’s, April 2005 Ethical Conduct of Clinical Research Involving Children: The Institute of Medicine Report, Annual Pediatric Bioethics Conference, Seattle, July 2005 Margaret Rosenfeld, MD, MPH Launching a Successful Academic Career, organizer and moderator, South Central Cystic Fibrosis Consortium, Houston, Texas, April 2005 Gregory J. Redding, MD Diagnosis of Wheezing in Infants and Young Children, Grand Rounds, University of New Mexico, Albuquerque, March 2005 Children with CF Do Not Benefit from Surveillance Bronchoscopies, CF Around the World: Same Disease, Different Treatments, American Thoracic Society International Conference, San Diego, May 2005 Gastro-esophageal Reflux in Children: A Pulmonary Perspective, American Academy of Pediatrics, New Mexico Chapter, N.M., March 2005 Pulmonary Exacerbations, 2005 Cystic Fibrosis Foundation Williamsburg Conference, Williamsburg, Va., June 2005 Diagnosis of Wheezing in Infants and Young Children, Grand Rounds, University of Texas, Houston, November 2005 Predictors of CF Morbidity and Mortality, CF Is Now an Adult Disease, 28th European Cystic Fibrosis Society Conference, Crete, Greece, June 2005 Measurements of Asthma in Infants and Young Children and Treatment of Acute Severe Asthma in Children, Intermountain Western Allergy Association, Sun Valley, Idaho, July 2005 Newborn Screening for CF: Is It Time? Advisory Committee to Washington State Board of Health to consider universal newborn screening for cystic fibrosis, Shoreline, Wash., July 2005 Gastro-esophageal Reflux in Children: A Pulmonary Perspective, Central Washington pediatric Grand Rounds, November 2005 Educational Opportunities, Department of Pediatrics new fellows orientation, Seattle Children’s, July 2005 Thoracic Insufficiency Syndrome in Children, Bronchiectasis in Childhood and Interstitial Lung Disease in Childhood: Update, Thoracic Society of Australia and New Zealand, Perth, Australia, March 2005 Pulmonary Considerations and Assessments in Children with Congenital Spine and Chest Wall Disorders, Pediatric Orthopedic Society of North America (POSNA), Ottawa, May 2005 Pulmonary Assessment of Congenital Kyphoscoliosis and Current Research Update on Pulmonary Measurements in Spine Disease of Children, master’s course in pediatric spine disorders, University of Texas at San Antonio, February 2005 180 Assessment of Spine Rotation and Lung Function Asymmetry in Children with Kyphoscoliosis, International Meeting on Advance Spine Techniques (IMAST), Banff, Canada, July 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON New Frontiers in Clinical Research: From Diagnosis to Therapy, moderator, University of Washington, General Clinical Research Center, First Annual Symposium, September 2005 Endpoints in CF Clinical Trials: One Size Does Not Fit All, Imaging Endpoints for Cystic Fibrosis Clinical Trials, sponsored by Cystic Fibrosis Foundation, Chantilly, Va., September 2005 Pediatric Asthma: An Update, Grand Rounds, Toppenish Hospital, Toppenish, Wash., September 2005 Monitoring for Early CF Lung Disease, roundtable moderator, North American Cystic Fibrosis Conference, Baltimore, November 2005 Pulmonary Medicine CF Clinical Research: An Update, Cystic Fibrosis Foundation Virtual Patient Education Day Webcast, November 2005 Gibson RL. Cystic fibrosis. In: Pediatrics. Osborn L, DeWitt T, First L, Zenel J, eds. Philadelphia: Elsevier Mosby, 2005: 1198–1207. Pulmonary Exacerbations: Definitions and Their Use in Clinical Trials, workshop for fellows in the Department of Pediatrics, South Central Cystic Fibrosis Consortium, Houston, Texas, December 2005 Hendeles L, Marshik P, Ahrensn R, Kifle Y, Shuster J. Response to nonprescription epinephrine inhaler during nocturnal asthma. Ann Allergy Asthma Immunol. 2005;95:530–534. PUBLICATIONS Carter E, Debley J, Redding G. Changes in asthma prevalence and impact on health and function in Seattle middle-school children: 1995 versus 2003. Ann Allergy Asthma Immunol. 2005;94:634–639. Chang AB, Redding GJ. Bronchiectasis. In: Kendig’s Disorders of the Respiratory Tract in Children (7th Edition). Chernick, Boat, Wilmott, Bush, 2005. Chen ML, Tablizo MA, Kun S, Keens TG. Diaphragm pacers as a treatment of congenital central hypoventilation syndrome. Expert Review of Medical Devices. 2005;2:577–585. Davis S, Gappa M, Rosenfeld M. Respiratory mechanics. In: Pediatric Pulmonary Function Testing Hammer J, Eber E, eds. Prog Respir Res. 2005;33:20–33. Debley JS, Carter ER, Gibson RL, Rosenfeld M, Redding GJ. The prevalence of ibuprofen-sensitive asthma in children: a randomized controlled bronchoprovocation challenge study. J Pediatr. 2005;147:233–38. Debley J, Smith J, Redding GJ, Critchlow C. Childhood asthma hospitalization risk after cesarean delivery in former term and premature infants. Ann Allergy Asthma and Immunol. 2005;94:228–233. Deterding R, Retsch-Bogart G, Milgram L, Gibson RL, Ramsey BR, et al. Safety and tolerability of Denufosol tetrasodium inhalational solution, a novel P2Y2 receptor agonist: results of a phase 1/phase 2 multi-center study in mild to moderate cystic fibrosis. Pediatr Pulmonol. 2005;39:339–348. Hoffman LR, Yen E, Van Niel C, Effman, E, Gibson RL. Lipoid pneumonia due to Mexican folk remedies: cultural barriers to diagnosis. Arch Pediatr Adolesc Med. 2005;159:1043–1048. Hoffman LR, D’Argenio DA, MacCoss MJ, Zhang Z, Jones RA, Miller SI. Aminoglycoside antibiotics induce bacterial biofilm formation. Nature. 2005;436:1171–1175. Kulich M, Rosenfeld M, Campbell J, Kronmall R, Gibson RL, Goss C, Ramsey BR. Disease-specific reference equations for lung function in patients with cystic fibrosis. Am J Resp Critic Care Med. 2005;172:885–891. Marshall SG, Debley JS. The respiratory system. In: Nelson Essential Pediatrics, 5th edition. 2005, 133–138. Moskowitz SM. A role for the vanishing physicianscientist? Letter to the editor of Journal of Clinical Investigation (comment on editorial by Marks AR, How to support the basic sciences, J Clin Invest, 115:2); e-publication, Jan. 20, 2005. Moskowitz SM, Foster JM, Emerson JC, Gibson RL, Burns JL. Use of Pseudomonas biofilm susceptibilities to assign simulated antibiotic regimens for cystic fibrosis airway infection. J Antimicrob Chemother. 2005;56:879–886. Moskowitz SM, Gibson RL, Effman E. Cystic fibrosis lung disease: genetic influences, microbial interactions, and radiologic assessment. Pediatr Radiol. 2005;35:739–757. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 181 Pulmonary Medicine Moss RB, Mayer-Hamblett N, Wagener J, Daines C, Hale K, Ahrens R, Gibson RL, et al. A randomized, double-blind, placebo-controlled, dose escalating study of aerosolized interferon Гђ-1b in patients with mild to moderate cystic fibrosis lung disease. Pediatr Pulmonol. 2005;39:209–218. Redding GJ (co-author and ad hoc subcommittee, American Thoracic Society). Statement on home care for patients with respiratory disorders. Am J Respir Crit Care Med. 2005;171:1443–1464. Rosenfeld M. Overview of published evidence on outcomes with early diagnosis from U.S. observational studies. J Pediatr. 2005;147:S11–S14. Saiman L, Mayer-Hamblett N. Heterogeneity of treatment response to azithromycin in patients with CF chronically infected with P. aeruginosa. Am J Respir Crit Care Med. 2005;172:1008–1012. 182 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Psychiatry and Behavioral Medicine The Department of Psychiatry and Behavioral Medicine provides a continuum of psychiatric services including inpatient, outpatient, day treatment and hospital and community consultations for youth with a wide spectrum of developmental, psychiatric and behavioral problems. Mental and behavioral problems result from a complex interplay of biological, environmental, psychological and social factors. Mental health disorders affect a significant and growing number of youth, and exact a significant cost in the lives of these children and their families. The psychiatry program at Seattle Children’s Hospital is in the top tier of pediatric behavioral medicine divisions in the country, serving as a national and regional resource. In conjunction with the University of Washington Department of Psychiatry, Seattle Children’s is the center of clinical training, research and pediatric mental health care for the WAMI region (Washington, Alaska, Montana, Idaho). The Department of Psychiatry is undergoing an expansion of its research in basic science, genetics, developmental psychopathology and health services related to understanding the origins, course and treatment of mental illness in children and adolescents. Seattle Children’s serves as the primary pediatric mental health training site for medical students, psychiatry and psychology residents and child psychiatrists for the University of Washington. In addition, we are committed to working collaboratively with medical colleagues in pediatrics and primary care throughout the region to expand the availability of mental health expertise and services to children, and we offer a variety of seminars and continuing education programs. The Department of Psychiatry and Behavioral Medicine is proud of its tradition as a leader in advancing knowledge of the origins and treatment of mental illnesses in youth, training clinician scientists and improving access to care. We are committed to growing these efforts to reach the increasing numbers of children and families in need. TEACHING, RESEARCH AND CLINICAL EXPERTISE Bryan H. King, MD, is director of Psychiatry and Behavioral Medicine at Seattle Children’s Hospital and professor and vice chair of Psychiatry and Behavioral Sciences at the University of Washington School of Medicine. He joined the university from FACULTY Bryan H. King MD, Director Bryan H. King, MD, Director Elizabeth McCauley, PhD, ABPP, Associate Director David Breiger, PhD Zoran Brkanac, MD Rosemary Calderon, PhD Lynda L. Carlisle, MD Heather Carmichael Olson, PhD Brent R. Collett, PhD Amy Henry, MD Dartmouth Medical School, where he held a similar position and served as medical director for New Hampshire’s Division of Developmental Services. Dr. King completed medical training at the Medical College of Wisconsin and a medical internship and psychiatric training at the UCLA Medical Center and Neuropsychiatric Institute. He obtained his clinical and research training in child and adolescent psychiatry at Stefanie Hlastala, PhD UCLA and the Merck Jon McClellan, MD Neuroscience Research Kathleen Myers, MD, MPH, MS, Center in England. Kelly Schloredt, PhD Dr. King’s clinical and Matthew Speltz, PhD research interests focus Michael G. Storck, MD on psychiatric aspects of Stephen Sulzbacher, PhD developmental disorders, Ann Vander Stoep, PhD Christopher Varley, MD and on severe behavioral disturbances in autism in particular. He chairs a multisite clinical trial SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 183 Psychiatry and Behavioral Medicine by the STAART (Studies to Advance Autism Research and Treatment) Centers examining an antidepressant medication in treatment of children with autism who have significant problems with repetitive behaviors. Dr. King is co-author of the American Academy of Child and Adolescent Psychiatry’s practice parameters for patients with developmental disorders and mental illnesses. He has received lifetime achievement awards from the American Academy of Child and Adolescent Psychiatry and from the American Psychiatric Association for his work on developmental disabilities. in children with thought disorders or chronic fatigue syndrome, the cultural context and understanding of autism and the evaluation of early intervention in children with autism. He supervises psychology residents at the university and also supervises post doctoral fellows in pediatric neuropsychology; he also lectures psychiatry fellows and pediatric residents, and teaches graduate seminars in the Department of Psychology at the University of Washington. Dr. Breiger has served as president of the Pacific Northwest Neuropsychological Society. Elizabeth McCauley, PhD, ABPP, is associate director of Psychiatry and Behavioral Medicine at Seattle Children’s Hospital and professor at the University of Washington with a primary appointment in psychiatry and joint appointments in psychology and pediatrics. She contributes to the Child Psychiatry Fellowship Seminar series, the child psychology internship didactic program and the university’s Department of Psychology graduate seminars on childhood psychopathology and treatment issues. She also participates in the university’s Continuing Medical Education programs and provides clinical supervision to psychiatry residents, child psychiatry fellows and psychology residents. She spends one week a month attending on Seattle Children’s psychiatry consultation and liaison service. She serves on the Children’s gender assessment team and sees patients who have medical conditions affecting the development of their genitalia or their pubertal development; she also does assessments of children with gender identity confusion. Her clinical work includes treating adolescents with mood disorders. For 19 years her research team has been engaged in a research program designed to characterize clinical depression in young people. She has also studied the psychosocial and cognitive functioning of girls and women with Turner syndrome and cloacal exstrophy. Zoran Brkanac, MD, is attending psychiatrist at Seattle Children’s Hospital and assistant professor at the University of Washington School of Medicine. He is board certified in child and adolescent psychiatry. His interests include behavioral genetics and the genetics of dyslexia. Dr. Brkanac received the University of Washington’s Department of Psychiatry Graduating Acknowledgment for Academic Excellence in 2001 and the Psychiatric Research Society Young Investigator Travel Award in 2002. David Breiger, PhD, is clinical program director of the neuropsychological assessment service at Seattle Children’s Hospital and clinical assistant professor at the University of Washington School of Medicine. Seattle Children’s neuropsychological assessment service evaluates children and adolescents with medical, neurological, psychological and genetic conditions that affect development, and provides inpatient and outpatient neuropsychological assessments. His interests include neuropsychological outcomes of children with brain tumors, neuropsychological functioning 184 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Rosemary Calderon, PhD, is attending psychologist at Seattle Children’s Hospital and associate professor in the Department of Psychiatry and Behavioral Sciences at the University of Washington. She is chief of psychiatric services for the Deaf and Hard of Hearing Program and chief of the Eating Disorders Program. Her clinical interests include long-term outcomes for adolescents with eating disorders (anorexia nervosa, bulimia nervosa) and hearing loss, and behavioral and psychiatric problems in children. Lynda L. Carlisle, MD, is attending psychiatrist at Seattle Children’s Hospital and acting assistant professor at the University of Washington School of Medicine. Her clinical interests include child abuse, post-traumatic stress disorder, pervasive developmental disorders, psychopathology in early childhood and metabolic effects of atypical antipsychotics. Heather Carmichael Olson, PhD, is attending psychologist at Seattle Children’s Hospital, senior lecturer in the Department of Psychiatry and Behavioral Sciences at the University of Washington School of Medicine and adjunct in the Department of Speech and Hearing Sciences at the university. She is also director of the Early Childhood Assessment and Intervention Clinic at Seattle Children’s and staff psychologist for the Fetal Psychiatry and Behavioral Medicine Alcohol Syndrome Diagnostic and Prevention Network at the university. Her research interests include fetal alcohol spectrum disorders (FASD); she is a research affiliate of the Alcohol and Drug Abuse Institute and the Center on Human Development and Disability. Her teaching responsibilities include clinical training for child psychiatry residents and psychology interns. She also does a wide variety of presentations to professional and lay audiences, typically on topics of FASD and the impact of parental substance abuse on child development and family function. She is an appointed member of the National FAS Task Force, a congressionally mandated committee designed to advance activities related to FASD. She is also vice president of the FASD Study Group, a satellite research organization with an international membership affiliated with the Research Society on Alcoholism. Brent R. Collett, PhD, is attending psychologist at Seattle Children’s Hospital and acting assistant professor at the University of Washington School of Medicine. Working in Seattle Children’s Early Childhood Clinic, he is involved in evaluation and treatment of children from birth to age 5 (and their families), particularly children who have complex medical conditions (e.g., craniofacial anomalies) in addition to developmental, behavioral or psychiatric problems. His research is primarily in the area of pediatric psychology and includes studies of children with craniofacial anomalies and survivors of childhood cancer. Dr. Collett also maintains an active research interest in the developmental psychopathology of disruptive behavior disorders. His teaching activities include supervision of child psychiatry fellows and psychology interns in the Early Childhood Clinic and didactic teaching related to early onset behavior problems and normative preschool-age development. Amy Henry, MD, is attending psychiatrist at Seattle Children’s Hospital and acting instructor in the Department of Psychiatry and Behavioral Sciences at the University of Washington. At Seattle Children’s she works in the inpatient psychiatry unit, and is medical director of the outpatient psychiatry clinic. She supervises child and adolescent psychiatry residents, general psychiatry residents and medical students both on the inpatient psychiatry unit and through the outpatient clinic. Dr. Henry also provides some clinical care as well as supervision to residents at community psychiatry sites including school-based clinics, Asian Counseling and Referral Services and a rural mental health center in Alaska. Her clinical interests include assessing and treating adolescents with self-harmful behaviors, depressive disorders, developmental disorders and anxiety disorders. Stefanie Hlastala, PhD, is attending psychologist at Seattle Children’s Hospital and acting assistant professor at the University of Washington School of Medicine. Her interests include early onset psychosis, and depression and bipolar disorders in youth and adolescents. She is principal investigator for an award aimed at adapting interpersonal and social rhythm therapy for use with adolescents who have bipolar disorder. She is a co-investigator on a multisite study examining the effectiveness and safety of lithium in youth with mania; she is also a co-investigator on a study examining the effectiveness and safety of antipsychotic medications in youth with schizophrenia spectrum disorders. Jon McClellan, MD, is medical director of Washington’s Child Study and Treatment Center (CSTC), the state hospital for children and adolescents, and associate professor at the University of Washington School of Medicine. His research focuses primarily on the diagnosis, phenomenology and treatment of early onset schizophrenia and bipolar disorder. Dr. McClellan is involved with two multisite treatment trials, one for early onset schizophrenia, the other for early onset bipolar disorder. He is also collaborating on genomic research for schizophrenia. He has been involved in the development of treatment guidelines for the American Academy of Child and Adolescent Psychiatry and authored the academy’s practice parameters on early onset schizophrenia and bipolar disorder. Dr. McClellan’s teaching responsibilities include resident supervision, research mentoring and didactic presentations for residents and university medical students. Kathleen Myers, MD, MPH, MS, is director of the psychiatry consultation and liaison service at Seattle Children’s Hospital and associate professor at the University of Washington School of Medicine. Her interests include telepsychiatry for youth living in underserved communities (especially those living in rural communities in Eastern Washington and Alaska), mood disorders in children and adolescents (especially bipolar disorder) and the mental health needs of medically ill children. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 185 Psychiatry and Behavioral Medicine Kelly Schloredt, PhD, is attending psychologist and research associate at Seattle Children’s Hospital and clinical assistant professor in the University of Washington School of Medicine. In the Seattle Children’s inpatient psychiatry unit and the consultation and liaison service, she supervises and clinically trains child psychiatry fellows, general psychiatry residents, psychology residents and medical students. She lectures in the didactic series for child fellows, general psychiatry residents and psychology residents; she has given a number of lectures for organizations including the Washington State Council on Child and Adolescent Psychiatry and the Pierce County Medical Society. She manages a multisite longitudinal research project following children of depressed parents as their parents undergo treatment for depression. She is also a co-investigator on a treatment development grant focused on adapting behavioral activation therapy for depressed adolescents and examining the efficacy of this treatment. Stephen Sulzbacher, PhD, is attending psychologist at Seattle Children’s Hospital and the University of Washington Medical Center. He is on the medical staff at Central Washington Hospital in Wenatchee, Wash., and is associate professor emeritus of the University of Washington School of Medicine. Dr. Sulzbacher’s research focuses on early identification of central nervous system effects of inborn errors of metabolism and on following up on children identified through the State Newborn Screening Program with periodic neuropsychological testing. He is also conducting research to study the effects of pesticides on the health of children of farm workers. Additionally, Dr. Sulzbacher does applied research to demonstrate the use of videoconferencing as a way to provide consultation to rural school districts serving children with special health care needs like autism. He provides regular telehealth consultation to rural practitioners and clinics throughout the state, as an adjunct to outreach clinics in which he participates. Matthew Speltz, PhD, is chief of outpatient service in the Department of Psychiatry and Behavioral Medicine at Seattle Children’s Hospital and professor in the Department of Psychiatry and Behavioral Sciences in the University of Washington School of Medicine. Dr. Speltz’s research focuses on the neurobehavioral development of children with craniofacial disorders, including cleft lip and palate, psychiatric assessment and diagnosis of adolescent disorders, disruptive disorders, autism, anxiety disorders and behavioral medicine. Ann Vander Stoep, PhD, is assistant professor with joint appointments in the Department of Psychiatry and Behavioral Sciences and the Department of Epidemiology at the University of Washington. Her research interests include developmental epidemiology of adolescent depression, mental health status of children in the juvenile justice system, transition to adulthood for adolescents with psychiatric disorders and development of children’s mental health interventions. She is a partner in launching the Developmental Pathways Research Program, a collaborative effort with the Seattle Public Schools to study the etiology of childhood depression and to develop effective strategies for prevention. She teaches psychosocial epidemiology in the university School of Public Health and provides research mentorship to epidemiology graduate students and junior scientists in the Department of Psychiatry and Behavioral Medicine. She also teaches basic epidemiological methods to graduate students in the university School of Nursing and the Community Oriented Public Health Practice Program in the Department of Health Services. Michael G. Storck, MD, is attending psychiatrist at Seattle Children’s Hospital and at Washington state’s Child Study and Treatment Center, and assistant professor at the University of Washington School of Medicine. He lectures on growth and development, cross-cultural psychiatry, spirituality, and religion and health, systems of care and narrative therapy. Dr. Storck is also a supervisor and preceptor for fourthyear medical students and University of Washington School of Nursing students. His clinical interests include child and adolescent psychiatry and crosscultural psychiatry with Native Americans. He is a university mentor and co-chair of the Colleges Medical Communications Committee. He is lead investigator in a study assessing patient and second-year medical student perspectives on the process of early clinical education, and co-investigator in a study on Navajo youth and the experience of psychiatric treatment. 186 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Christopher Varley, MD, is attending psychiatrist and medical director of the inpatient psychiatric unit at Seattle Children’s hospital; he is also attending psychiatrist for the outpatient psychiatry clinic. He is consulting psychiatrist for the Gateway Center for Human Services in Ketchikan, Alaska. He is professor Psychiatry and Behavioral Medicine in the University of Washington School of Medicine Department of Psychiatry and Behavioral Sciences and is training director for the Division of Child and Adolescent Psychiatry. His clinical interests include pediatric psychiatry and psychopharmacology. Hemifacial Microsomia: Psychosocial and Other Sequelae, Boston University, National Institute of Dental and Craniofacial Research/NIH/DHHS, $100,126 TEACHING AND PRESENTATIONS AWARDS AND HONORS Jon McClellan, MD Dr. Alexander Gralnick Award from the Child Welfare League of America, 2005 Kathleen Myers, MD, MPH, MS Teaching Excellence University of Washington Fellowship in Child and Adolescent Psychiatry, 2005 RESEARCH FUNDING New Heather Carmichael Olson, PhD Intervention for Individuals with Fetal Alcohol Syndrome: Transitioning Science to Community Projects, Centers for Disease Control and Prevention/ DHHS, $300,001 Matthew Speltz, PhD Neurodevelopment Among Infants with Deformational Plagiocephaly, National Institute of Child Health and Human Development/NIH/DHHS, $479,500 Continuing Elizabeth McCauley, PhD, ABPP Treatment of Depression in Parents: Impact on Children, National Institute of Mental Health/NIH/ DHHS, $240,099 Jon McClellan, MD Treatment of Early Onset Schizophrenia Spectrum (TEOSS), National Institute of Mental Health/NIH/ DHHS, $170,043 Matthew Speltz, PhD Neurobehavioral Correlates of Craniosynostosis, National Institute of Dental and Craniofacial Research/NIH/DHHS, $818,170 Rosemary Calderon, PhD Management of Eating Disorders, WSCCAP Spring Conference, Seattle, April 30, 2005 Heather Carmichael Olson, PhD Helping Families Move Forward: Practical Ideas Based on FASD Research, National Fetal Alcohol Spectrum Disorders Conference, Victoria, BC, Canada, February 2005 Fetal Alcohol Spectrum Disorders—An Overview: Understanding Childhood and Looking to the Future, Pacific Northwest Neuropsychological Society Annual Conference, Seattle, March 2005 Children with Fetal Alcohol Spectrum Disorders: The Relationship of Children’s Deficits and Parenting Challenges (poster presentation) and Caregiver Expressed Emotion and Child Problem Behavior in Families Raising Children with Fetal Alcohol Spectrum Disorders, biennial meeting of the Society for Research in Child Development, Atlanta, April 2005 Psychiatric Diagnosis and Medication in Fetal Alcohol Spectrum Disorders, annual meeting of the American Psychiatric Association, Atlanta, May 2005 Efficacy of a New Model of Behavioral Consultation for Families Raising School-Aged Children with FASD and Behavior Problems, annual meeting of the Research Society on Alcoholism, Atlanta, June 2005 Brent R. Collett, PhD Presurgery Development of Infants with Isolated Craniosynostosis, annual conference of the American Cleft Palate–Craniofacial Association, Myrtle Beach, S.C., April 2005 Amy Henry, MD Depression and Antidepressants in Adolescents, University of Washington School of Nursing Pediatric Drug Therapy Pharmacology Conference, March 2005 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 187 Psychiatry and Behavioral Medicine Psychopathology and the DSM-IV, epidemiology graduate mental health seminar, University of Washington, April 2005 Adolescent Depression: Prevention and Treatment Approaches, Grand Rounds: University of Rochester, Department of Psychiatry, Rochester, N.Y., April 2005 DBT Case Management Techniques, Harborview DBT seminar, Seattle, October 2005 Changes in Family Environment and Child Functioning in Relation to Changes in Parental Depression; Treating Parents’ Depression: How Does It Affect Their Children? (symposium); and Methodological Considerations in Implementing Preventive Interventions to Reduce Risk for Depression in Adolescence (symposium chair), SRCD, Atlanta, April 2005 Appetite and Weight-Related Side Effects of Medications, Seattle Children’s, October 2005 Depression and Antidepressants in Adolescents, University of Washington School of Nursing Advanced Practice in Primary and Acute Care Conference, October 2005 Bryan H. King, MD Psychopharmacologic Targets in Autism, UCLA Center for Autism Research and Treatment seminar series, Los Angeles, January 2005. Autism 2005 (keynote presentation) and Autism and Medication, University of Florida Center for Autism and Related Disabilities Annual Conference, Orlando, Fla., January 2005 Overview of Psychotropic Drug Use in Persons with Developmental Disabilities; Innovative Approaches: Treatment for People with Developmental Disabilities & Psychiatric Disorders, Northern California Regional Centers Conference on Wellness in Developmental Disabilities, Sacramento, Calif., January 2005 Contributions of St. Kitts to Psychiatry and Neuroscience, Benjamin Rush Society annual meeting, St. Kitts, W.I., February 2005 Pharmacotherapeutic Targets in Autism, psychiatry Grand Rounds, Seattle Children’s, October 2005 Causality, Intervention and Support in Relation to People with Intellectual Disability Who Self-Injure, keynote lecture, Royal Society of Medicine Intellectual Disability Forum, London, December 2005 Elizabeth McCauley, PhD, ABPP Mental Health Update—Treating Mental Disorders in General Medical Settings, Managing Depressed Adolescents, University of Washington, February 2005 188 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON School-Based Screening for Emotional Health (poster presentation), Society for Prevention Research, Washington, D.C., May 2005 Forms and Meanings of Comorbid Psychopathology (symposium discussant) and Cognitive Style: Externalizing and Internalizing Disorders (poster presentation), ISRCAP meetings, New York, June 2005 Jon McClellan, MD Early Onset Schizophrenia, Child Welfare League of America, Washington D.C., March 2005 Kathleen Myers, MD, MPH, MS Pediatric Telemental Health: Reach Out and Touch Kids on Their Home Turf — Part One, 9th annual meeting of the American Telemedicine Association, Denver, 2005 Kelly Schloredt, PhD Epidemiology of Pediatric Obesity and Comprehensive Weight Management in Children, Washington State Council on Child and Adolescent Psychiatry Spring Conference, Seattle, April 2005 Motivational Interviewing Practice Sessions: Preschool Children (breakout session), Pediatric Weight Management: Skills & Resources for Providers Conference, Seattle Children’s and University of Washington School of Medicine, April 2005 Michael G. Storck, MD To Medicate Kids or Not?: The вЂ�Psychologic’ and вЂ�Physiologic’ Aspects of Medication and Non-Medication, University of Washington Neuropsychotropic Drug Therapy Conference, March 2005 Psychiatry and Behavioral Medicine Exile and Refuge: An Update on Youth at Child Study and Treatment Center, Psychiatry Grand Rounds, Seattle Children’s, June 2005 Ann Vander Stoep, PhD Methodological Considerations in Identification of a Target Group for Preventive Interventions Methodological Considerations in Implementing Preventive Interventions to Reduce Risk for Depression in Adolescence symposium, Society for Research in Child Development, Atlanta, April 9, 2005 Concurrent Heterotypic Co-Morbidity: Depressive and Disruptive Behavior Problems in Early Adolescence, and Forms and Meanings of Co-morbid Psychopathology (symposium chair and presenter), International Society for Research in Child and Adolescent Psychopathology, New York, June 25, 2005 School-Based Emotional Health Screening, University of Washington School of Public Health and Community Medicine epidemiology seminar, June 7, 2005 Christopher Varley, MD ADHD in Adults, Western State Hospital Grand Rounds, Steilacoom, Wash., March 3, 2005 Meeting Residency Education Challenges as New Directors, American Association of Directors of Psychiatric Residency Training annual meeting, Tucson, Ariz., March 10, 2005 Gained in Translation: Evidence-Based Medicine Meets Psychiatric Training, American Association of Directors of Psychiatric Residency Training annual meeting, Tucson, Ariz., March 12, 2005 Anxiety Disorders, Child Clinical Consultation Forum, Anxiety Disorders Association of America 25th Annual Conference, Seattle, March 18, 2005 Current Issues in Pediatric Psychopharmacology, Developmental and Behavioral Pediatrics Update, Seattle Children’s, April 2, 2005 Childhood Psychopathology, Cascadia Training in Foster Care and Adoption Therapy, Northwest Resource Associates, Seattle, May 13–14, 2005 ADHD and Other Disruptive Behaviors in Preschool Children: Challenges in Diagnosis and Treatment, Pediatric Academic Societies annual meeting, Washington, D.C., May 15, 2005 Antidepressants in Kids: The Controversy, Pharmacology Conference: Neuropsychotropic Drug Therapy, University of Washington School of Nursing, Shoreline, Wash., June 10, 2005 Antidepressants in Children and Adolescents, 33rd Annual Advances in Family Practice and Primary Care, University of Washington School of Medicine, September 15, 2005 Management of ADHD Across the Age Spectrum, Management of Chronic Mental Illnesses, University of Washington School of Medicine, September 30, 2005 Essentials for Training Directors, 52nd annual meeting of the American Academy of Child and Adolescent Psychiatry, Toronto, October 20, 2005 Depression/Anxiety, Autism and Behavior Management and ADHD and Comorbidities: Assessment and Treatment, Pediatric Update Conference, Providence Everett Medical Center, Everett, Wash., November 10, 2005 PUBLICATIONS Bostic JQ, King BH. Autism spectrum disorders: emerging pharmacotherapy. Expert Opin Emerg Drugs. 2005;10(3):521–536. Cheng K, Myers KM, eds. Child and Adolescent Psychiatry: The Essentials. New York: Lippincott, Williams & Wilkins, 2005. Collett BR, Breiger D, King D, Speltz ML, Cunningham M. Neurobehavioral aspects of deformational plagiocephaly: review of research and critical issues. J Dev Behav Pediatr. 2005;26:1–11. Collett BR, Myers KM. Suicide. In: Child and Adolescent Psychiatry: The Essentials. Meyers K, Cheng K, eds. New York: Lippincott, Williams & Wilkins, 2005;299-320. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 189 Psychiatry and Behavioral Medicine Collett BR, Breiger D, King D, Cunningham M, Speltz ML. Neurodevelopmental implications of “deformational” plagiocephaly. J Dev Behav Pediatr. Oct 2005;26(5):392. Jensen J, Breiger D. Learning disorders. In: Child and Adolescent Psychiatry: The Essentials for Primary Care. Cheng K, Myers K, eds. New York: Lippincott, Williams, & Wilkins, 2005. Crowell S, Beauchaine TP, McCauley E, Smith C. Autonomic and serotonergic correlates of parasuicidal behavior in adolescents. Dev Psychopathol. 2005; 17:1–23. Kapp-Simon K, Leroux B, Cunningham M, Speltz ML. Multisite study of infants with singlesuture craniosynostosis: preliminary report of pre-surgery development. Cleft Palate-Craniofac. July 2005;42(4):377–385. Edwards T, Patrick D, Topolski T, Aspinall C, Mouradian W, Speltz ML. Approaches to craniofacialspecific quality of life assessment in adolescents. Cleft Palate-Craniofac. Jan 2005;42(1):19–24. Geyer JR, Sposto R, Jennings M, Boyett JM, Axtell RA, Breiger D, Broxson E, Donahue B, Finlay JL, Goldwein JW, Heier LA, Johnson D, Mazewski C, Miller DC, Packer R, Puccetti D, Radcliffe J, Tao ML, Shiminski-Maher T, Children’s Cancer Group. Multiagent chemotherapy and deferred radiotherapy in infants with malignant brain tumors: a report from the Children’s Cancer Group. J Clin Oncol, 2005. Gimpel GA, Collett BR, Veeder M, Bushman B, Sneddon P, Hughes K, Odell JD. The effects of stimulant medication on the cognitive performance of children with ADHD. Clin Pediatr. 2005;44:405–411. Harle J, McClellan J. Family and group psychosocial interventions for child- and adolescent-onset schizophrenia. In: Juvenile-Onset Schizophrenia: Assessment, Neurobiology and Treatment. Findling RL, Schultz SC, eds. Baltimore: John Hopkins University Press, 2005. Hlastala SA, McClellan JM. Early onset schizophrenia and related psychotic disorders. In: Child and Adolescent Psychiatry: The Essentials. Meyers K, Cheng K, eds. New York: Lippincott, Williams & Wilkins, 2005. Hlastala SA, McClellan JM. Phenomenology and diagnostic stability of youth with atypical psychotic symptoms. J Child Adolesc Psychopharmacol. 2005;15:497–509. Hodes M, Calderon R, Varley C, Breuner CC. Treatment of eating disorders in children and adolescents. In: The Cambridge Handbook of Effective Treatments in Psychiatry (in press). 190 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON King BH, Hodapp R, Dykens E, Mental Retardation. In: Comprehensive Textbook of Psychiatry–VIII. Kaplan, Sadock, eds. Baltimore: Williams and Wilkins, 2005;3076–3106. King BH, State M, Maerlender A. Mental Retardation. In: Clinical Child Psychiatry, 2nd Edition. Klykylo W, Kay J, Rube D, eds. Philadelphia: WB Saunders Co., 2005;391–413. Kuo ES, Vander Stoep A, Stewart DG. Assessing screening tools for depression in the juvenile justice system. Assessment. 2005;12:374–383. Leichner P, Hall D, Calderon R. Meal support training for friends and families of patients with eating disorders. Eating Disorders – The Journal of Treatment and Prevention: Special issue “Addressing the Needs of Parents.” July/September 2005;13:4. Losh DP, Mauksch LB, Arnold RW, Maresca TM, Storck MG, Maestas RR, Goldstein E. Teaching inpatient communication skills to medical students: an innovative strategy. Acad Med. Feb 2005;80(2):118–124. McCarty CA, Vander Stoep A, Kuo ES, McCauley E. Depressive symptoms among delinquent youth: testing models of association with stress and support. J Psychopathol Behav Assess. 2005;28:85–94. McClellan J. Commentary: treatment guidelines for child and adolescent bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2005;44(3):236–239. McClellan J. Early onset schizophrenia. In: Sadock’s Comprehensive Textbook of Psychiatry/VIII. Kaplan and Kaplan, eds. Baltimore: Lippincott, Williams & Wilkins, 2005. Psychiatry and Behavioral Medicine McClellan JM. Evidence-based therapies in child and adolescent psychiatry. Psychiatric Times. 2005;22:17–20. Myers KM, Collett BR. Psychiatric rating scales: theory and practice. In: Child and Adolescent Psychiatry: The Essentials. Meyers K, Cheng K, eds. New York: Lippincott, Williams, & Wilkins, 2005. Raskind WH, Igo RP, Chapman NH, Berninger VW, Thompson JB, Matsushita M, Brkanac Z, Holzman T, Brown M, Wijsman EM. A genome scan in multigenerational families with dyslexia: identification of a novel locus on chromosome 2q that contributes to phonological decoding efficiency. Mol Psychiatry. Jul 2005;10(7):699–711. Rockhill CR, Hlastala S, Myers KM. Bipolar disorder, Early onset bipolar disorder (two chapters). In: Child and Adolescent Psychiatry: The Essentials. Meyers K, Cheng K, eds. New York: Lippincott, Williams & Wilkins, 2005;191–210. Vander Stoep A, McCauley E, Thompson K, Kuo ES, Herting J, Stewart D, Anderson C, Kushner S. Universal screening for emotional distress during the middle school transition. Journal of Emotional and Behavioral Disorders. 2005;13:213–223. Varley CK, Jibson MD, McCarthy M, Benjamin S. A survey of the interactions between psychiatry residency programs and the pharmaceutical industry. Acad Psychiatry. 2005;29(1):40–46. Weber W, Taylor JA, Vander Stoep A, Weiss NS, Standish JL, Calabrese C. Echinacea purpurea for prevention of upper respiratory tract infections in children. J Altern Complement Med. 2005;11(5): 1021–1026. Winters NC, Collett BR, Myers KM. Ten-year review of rating scales VII: scales assessing functional impairment. J Am Acad Child Adolesc Psychiatry. 2005;44:309–338. Rosen M, Brady R, Long T, Minkel J, Reed P, Richards J, Sulzbacher S, Zabala J. An introductory curriculum for assistive technology, 2005; e-publication. Sattler JM, Breiger D. Brain injuries: formal batteries and informal measures. In: Assessment of Children: Behavioral and Clinical Applications, 5th Edition. San Diego: Sattler, 2005. Saxon AJ, Oreskovich MR, Brkanac Z. Genetic determinants of addiction to opioids and cocaine. Harv Rev Psychiatry. Jul–Aug 2005;13(4):218–232. Schloredt K, Varley CK. Current perspectives on diagnosis and treatment of adolescent depression in the primary care setting: a case-based review. J Clin Outcomes Manag. 2005;12(5):260–274. Storck M, Weber W, Vander Stoep A. Complementary and complex interventions in child psychiatric treatment. In: Cambridge Manual on Evidence-Based Care for Child Psychiatric Disorders. Cambridge University Press, 2005. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 191 Radiology The Department of Radiology has the largest concentration of board-certified specialists in pediatric radiology in the Northwest. Serving the needs of hospital-based physicians and community providers, 12 full- and part-time radiologists offer the full array of pediatric radiology and medical imaging services. Our dedicated staff members are uniquely trained and skilled in the care of infants, children, adolescents and their families. Our team of technologists achieves the best possible images in a child-friendly environment while always keeping radiation safety in mind. We perform and interpret more than 75,000 examinations each year. Our team’s complete range of diagnostic and therapeutic imaging services includes radiography, computed tomography, fluoroscopy, magnetic resonance imaging, nuclear medicine, ultrasound, bone densitometry and 3-D imaging data reconstruction and analysis. Seattle Children’s provides a complete range of vascular and interventional radiology procedures, including diagnostic and therapeutic procedures. Therapeutic procedures include body and cerebral embolization of tumors and vascular malformations as well as fibrinolysis, abscess drainage, radiofrequency ablation, gastrostomy and joint and tendon injections. Faculty members are authorities in neuroradiology, thoracic and abdominal imaging, musculoskeletal imaging, neonatal radiology, oncologic imaging and vascular and interventional procedures. We are continually enhancing our digital information capability in such areas as speech recognition software for rapid report turnaround, PACS systems for soft copy reading and teleradiology review for off-hours consultation. Children’s provides radiation oncology services through our affiliations with the Seattle Cancer Care Alliance and the University of Washington Medical Center. The Department of Radiology, in association with the University of Washington School of Medicine, educates radiology residents and trains fellows in pediatric radiology in an American College of Graduate Medical Education (ACGME)–approved fellowship. Faculty members are engaged in a variety of research projects in the areas of neuro-oncology, behavioral disorders, craniofacial malformations, functional brain imaging, oncology, medical informatics and 3-D image and high-resolution analysis. TEACHING, RESEARCH AND CLINICAL EXPERTISE Eric L. Effmann, MD, is director of the Department of Radiology at Seattle Children’s Hospital and division director of the Section of Pediatric Radiology and professor of radiology at the University of Washington School of Medicine. He has served as chief of pediatric imaging at Duke University Medical Center. Dr. Effmann has a long-time interest in basic and clinical aspects of pediatric chest disease with particular interest in early cardiopulmonary development, congenital lung lesions and quantitative and functional chest imaging. He is a major contributor to the 10th and 11th editions of Caffey’s Pediatric X-Ray Diagnosis. Dr. Effmann served in a variety of capacities in the Society for Pediatric Radiology, including president, and received the society’s Gold Medal, its highest 192 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON honor. He is member of two honorary societies, the Fleischner Society (chest disease) and the John Caffey Society (pediatric radiology). Dr. Effmann serves on the editorial board of Pediatric Radiology and is a regular examiner for the American Board of Radiology for general boards and subspecialty board credentialing. David K. Brewer, MD, is division chief of Computed Tomography at Seattle Children’s Hospital and associate professor of radiology at the University of Washington School of Medicine. He trained as the department’s first fellow in pediatric radiology in 1977. He completed his radiology residency and pediatric radiology fellowship through the university. Dr. Brewer performs radiologic-pathologic correlation on many of the department cases and has served as pediatric radiology fellowship director since 1999. Radiology Stephen L. Done, MD, is division chief of general diagnosis in the Department of Radiology at Seattle Children’s Hospital and clinical associate professor of radiology and pediatrics at the University of Washington School of Medicine. He completed his residency in pediatrics at the Letterman Army Medical Center in San Francisco, his diagnostic radiology residency at Massachusetts General Hospital, Harvard Medical School and a pediatric radiology fellowship at Children’s Hospital Boston, Harvard Medical School. He was chief of diagnostic radiology at Walter Reed Army Medical Center and director of residency training when he retired from the army in 1989. He has a clinical interest in early X-ray recognition of disease, skeletal dysplasias and child abuse. He is an active member in several national radiology societies. C. Benjamin Graham, MD, is staff radiologist and attending physician at Seattle Children’s Hospital; he is professor emeritus of radiology and pediatrics at the University of Washington School of Medicine. His training included internship, residency and pediatric radiology fellowship through the university, Seattle Children’s Hospital and the Karolinska Institute in Stockholm, Sweden. Dr. Graham has served as associate director and director of radiology. He continues to work part time with special interests in teaching, general diagnosis, developmental conditions and skeletal dysplasias. He has 47 publications and is a member of many local, national and international societies. Angelisa M. Paladin, MD, is the radiology residency coordinator at Seattle Children’s Hospital and assistant professor of radiology at the University of Washington School of Medicine. She completed her radiology residency at University of Texas Southwestern/Parkland Hospital and her pediatric radiology fellowship FACULTY Eric L. Effmann, MD, Director David K. Brewer, MD Stephen L. Done, MD C. Benjamin Graham, MD Angelisa M. Paladin, MD Marguerite T. Parisi, MD, MS Ed. Grace S. Phillips, MD through the University of Washington. She has a clinical research interest in pediatric urological conditions and the temporal bone. She is a member of several local and national radiology societies. Marguerite T. Parisi, MD, MS Ed., is division chief of ultrasound at Seattle Children’s Hospital and associate professor of radiology and pediatrics at the University of Washington School of Medicine. She completed her pediatrics residency at Children’s Hospital of Buffalo and trained as a radiology resident with fellowships in pediatric radiology and nuclear medicine. She earned her MS in medical education from the University of Southern California. Dr. Parisi’s clinical and research interests center around oncologic imaging, including evaluation of new techniques, modalities and imaging agents and their utilization, efficacy and clinical outcomes in both pediatric radiology and nuclear medicine. She has special expertise in the use of metaiodobenzylguanidine to image neuroblastoma and the use of Iodine-131 radiotherapy to treat pediatric thyroid cancer. She developed the pediatric bone densitometry (DXA) program at Seattle Children’s. She actively participates in many regional and national radiology societies and in numerous national committees including the national oncology cooperative, Childrens Cancer Group. She is president of the Pediatric Council of the Society of Nuclear Medicine and is also chair of the Nuclear Medicine Committee of the Society of Pediatric Radiology. Grace S. Phillips, MD, is attending physician at Seattle Children’s Hospital and acting assistant professor of radiology at the University of Washington School of Medicine. She completed her diagnostic radiology residency at the Mallinckrodt Institute of Radiology and her pediatric radiology fellowship through the University of Washington. She has a clinical interest in David M. Rosenbaum, MD Dennis W.W. Shaw, MD pediatric genitourinary Manrita K. Sidhu, MD radiology, organ transEdward Weinberger, MD plantation, body imaging and resident education. She is an active member in regional and national societies. Eric L. Effmann MD, Director SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 193 Radiology David M. Rosenbaum, MD, is division chief of nuclear medicine at Seattle Children’s Hospital and associate professor of radiology at the University of Washington School of Medicine. He completed his pediatric radiology fellowship at Children’s Hospital Boston. He has a clinical interest in nuclear medicine and general pediatric radiology. He is an active member in many regional and national radiology societies. Dennis W.W. Shaw, MD, is division chief of pediatric vascular-interventional radiology at Seattle Children’s Hospital and professor of radiology at the University of Washington School of Medicine. He completed pediatric and neuroradiology fellowships through the University of Washington. He divides his clinical time between pediatric interventional and neuroradiology services. His research interests include morphometric brain imaging and MR spectroscopy applied to autism. He has a particular interest in neuro-oncologic imaging and is a member of the Radiology Subcommittee within the Children’s Oncology Group, a national oncologic cooperative. He is also a member of the Neuroimaging Committee of the Pediatric Brain Tumor Consortium. Manrita K. Sidhu, MD, is staff radiologist at Seattle Children’s Hospital and assistant professor of radiology at the University of Washington School of Medicine. She completed her pediatric radiology fellowship at the University of Washington and a fellowship in vascular and interventional radiology at Stanford University Hospital. She has a clinical and research interest in pediatric vascular malformations and tumors. She is an active member of Seattle Children’s Dialysis Access Committee and Medical Staff Nominating Committee and is part of the expert panel of the Agency for Healthcare Research and Quality Pediatric Quality Indicators. She is also an active member of the Vascular/Interventional Committee and Poster Committee of the Society for Pediatric Radiology and a member of the Educational Evaluation Committee of the American Roentgen Ray Society. Edward Weinberger, MD, is division chief of magnetic resonance imaging and division chief of informatics at Seattle Children’s Hospital; he is professor of radiology, adjunct professor of pediatrics and professor of neurological surgery at the University of Washington School of Medicine. He completed his pediatric residency, his diagnostic radiology residency, and a 194 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON pediatric radiology fellowship through the University of Washington. He has a clinical interest in pediatric neuroradiology and research interests in medical and imaging informatics. He is a member of many local and national societies, serving as member of the General and Pediatric Committee of the American College of Radiology Commission on Standards and Accreditation and as member of the Radiological Society of North America’s Radiology Lexicon Committee. He is a board examiner for the American College of Radiology. AWARDS AND HONORS Stephen L. Done, MD Teacher of the Year, Department of Radiology, University of Washington School of Medicine Eric L. Effmann, MD Listed in “Best Doctors 2005,” Seattle magazine Dennis W.W. Shaw, MD Listed in “Best Doctors 2005,” Seattle magazine Edward Weinberger, MD Summa Cum Laude Award, Interactive Atlas of Pediatric Brain CT/MR Imaging, ASNR annual meeting TEACHING AND PRESENTATIONS Stephen L. Done, MD A Newly Described Mutation in the Calcium-Sensing Receptor Gene, Ray E. Helfer Society 5th annual meeting, New Paltz, N.Y., October 2005 Eric L. Effmann, M.D. Vertical Expandable Prosthetic Titanium Rib (VEPTR) and Bronchopulmonary Fistula/Hydropneumothorax, John Caffey Society annual meeting, San Francisco, June 22–25, 2005 Marguerite T. Parisi, MD, MS, Ed. The Role of Nuclear Medicine in Evaluation and LongTerm Follow Up of Children with Cancer, American Pharmacists Association annual meeting, Orlando, Fla., April 2, 2005 Radiology Developmental Anomalies of the Upper Urinary Tract in Children, postgraduate course; Genitourinary Section of Post Graduate Course, course co-development; Essentials of Pediatric Genitourinary Imaging I, moderator and course development; Essentials of Pediatric Genitourinary Imaging II, moderator and course development; Pediatric Uroradiology Case Review: Masters Cases; and Interactive Digital Atlas of the Pediatric Skeletal System, The Society for Pediatric Radiology 48th annual meeting, New Orleans, May 3–6, 2005 Neonatal Abdominal Masses: Pediatric GU 101, Canadian Society of Nuclear Medicine annual meeting, Vancouver, BC, Canada, May 12, 2005 Pediatric PET, PET/CT and CT Anatomy for the Nuclear Medicine Physician, moderator and course development, 52nd annual meeting of the Society of Nuclear Medicine, Toronto, June 18, 2005 Pediatrics “Read with the Experts,” moderator and course co-development, 52nd annual meeting of the Society of Nuclear Medicine, Toronto, June 19, 2005 Interpretation of Infrequently Performed Pediatric Nuclear Medicine Procedures—Includes Adult Diseases Presenting in the Pediatric World, course organizer, 52nd annual meeting of the Society of Nuclear Medicine, Toronto, June 20, 2005 Pediatric DEXA: Indications, Strategies for Developing a Referral Base; and Adult and Pediatric DEXAApplications and Interpretation, moderator and course organizer, 52nd annual meeting of the Society of Nuclear Medicine, Toronto, June 22, 2005 Manrita K. Sidhu, MD 3D CTA of Pediatric Head and Neck Vascular Anomalies, The Society for Pediatric Radiology 48th annual meeting, New Orleans, May 3–6, 2005 Pediatric Interventional Radiology for Urology, Department of Urology, Seattle Children’s, September 2005 Edward Weinberger, MD Interactive Digital Atlas of the Pediatric Skeletal System, The Society for Pediatric Radiology 48th annual meeting, New Orleans, May 3–6, 2005 Interactive Atlas of Pediatric Brain CT/MR imaging, American Society of Neuroradiology annual meeting, Toronto, May 21–27, 2005 Interactive Digital MR Atlas of the Pediatric Knee, Association of University Radiologists annual meeting, Montreal, May 4–7, 2005 PUBLICATIONS Amundsen LB, Artru AA, Dager SR, Shaw DWW, Friedman S, Sparks B, Dawson G. Propofol sedation for longitudinal pediatric neuroimaging research. J Neursurg Anesthsiol. 2005;17:180–192. Bittles MA, Sidhu MK, Sze RW, Perkins JA, Finn L. Multidetector CT angiography of pediatric vascular malformations and hemangiomas: utility of 3-dimensional reformatting in differential diagnosis. Pediatr Radiol. 2005;35(11):1100–1106. Pediatric DXA: Background, Indications, Strategies for Developing a Referral Base, Interpretation, Seattle Children’s, November 18, 2005 Doherty D, Glass IA, Siebert JR, Strouse PJ, Parisi MA, Shaw DWW, Chance PF, Barr M, Nyberg D. Prenatal diagnosis in pregnancies at risk for Joubert syndrome by ultrasound and MRI. Prenat Diagn. 2005;25:442–447. Grace S. Phillips, MD Interactive Digital Atlas of the Pediatric Skeletal System, The Society for Pediatric Radiology 48th annual meeting, New Orleans, May 3–6, 2005 Hoffman LR, Yen EH, Kanne JP, Effmann EL, Gibson RL, Van Niel CW. Lipoid pneumonia due to Mexican folk remedies: cultural barriers to diagnosis. Arch Pediatr Adolesc Med. Nov 2005;159(11):1043–1048. Mayock R, Phillips G, Parisi MT, Ngo A, deRegt D, Weinberger E. Interactive digital atlas of the pediatric skeletal system. Pediatr Radiol. 2005;35(S-1):S92. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 195 Radiology Moskowitz SM, Gibson RL, Effmann EL. Cystic fibrosis lung disease: genetic influences, microbial interactions, and radiological assessment. Pediatr Radiol. 2005;35:739–757. Parisi MA, Doherty D, Eckert ML, Shaw DWW, Ozyurek H, Aysun S, Giray O, Adulrahman AS, Al Shahwan S, Dohayan N, Bakhsh E, Indridason OS, Dobyns WB, Bennett CL, Change PF, Glass IA. AHI1 mutations cause both renal dystrophy and renal cystic disease in Joubert syndrome. J Med Genet, Sept 9, 2005; e-publication. Parisi MT. Developmental abnormalities of the upper urinary tract in children. Post Graduate Course Syllabus, The Society for Pediatric Radiology 48th annual meeting, 88–93, 2005. Perkins JA, Sidhu M, Manning SC, Ghioni V, Sze RW. Three-dimensional CT angiography imaging of vascular tumors of the head and neck. Int J Pediatr Otorhinolaryngol. 2005; 69(3):319–325. Sidhu MK, Perkins JA, Shaw DWW, Bittles MA, Andrews RT. Ultrasound-guided endovenous diode laser in the treatment of congenital venous malformations: preliminary experience. J Vasc Interv Radiol. 2005; 16:879–884. Strand AD, Aragaki AK, Shaw DWW, Bird T, Holton J, Turner C, Tapscott SJ, Tabrizi SJ, Schapira A, Kooperberg C, Olson JM. Gene expression in Huntington’s disease skeletal muscle: a potential biomarker. Hum Mol Genet. Jul 2005; 4(13):1863–1876. 196 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Rehabilitation Medicine The Department of Rehabilitation Medicine helps children and their families adapt to changes in functioning brought on by injury, illness or congenital defect. The department includes the divisions of Occupational Therapy, Speech and Language Services, Physical Therapy and Rehabilitation Psychology. As the regional leader in pediatric rehabilitation, we receive patients from the WAMI region (Washington, Alaska, Montana, Idaho). The Seattle Children’s rehabilitation program draws on the experience and expertise of its staff of board-certified pediatric physiatrists; nurses; occupational, physical and recreational therapists; speech and language pathologists; teachers; social workers; child clinical psychologists; neuropsychologists; and nutritionists. These professionals perform a comprehensive assessment of each child’s needs and abilities and develop short- and long-term treatment plans suited to the individual child’s medical and family circumstances. Rehabilitation services are provided for inpatients and outpatients at Seattle Children’s Hospital. Outpatient services are offered through the Rehabilitation Medicine Clinic as well as through our arthrogryposis, brachial plexus, limb deficiency and Muscular Dystrophy Association sub-specialty clinics. Physician outreach clinics are held in Yakima and Bellingham, Wash. and some outpatient therapy services are available at our satellite location in Bellevue, Wash. Inpatient care is provided in our new 12-bed unit, which is certified by the Rehabilitation Accreditation Commission (CARF) as a Pediatric Family-Centered Program in Medical Rehabilitation, and designated by the State Department of Health as the only Level I Pediatric Trauma Rehabilitation Center in Washington. TEACHING, RESEARCH AND CLINICAL EXPERTISE Kenneth M. Jaffe, MD, is director of the Department of Rehabilitation Medicine at Seattle Children’s Hospital; he is professor of rehabilitation medicine and adjunct professor of pediatrics and neurological surgery at the University of Washington School of Medicine. He is board certified in pediatrics and physical medicine and rehabilitation. His clinical activities include inpatient rehabilitation and outpatient clinics at Seattle FACULTY Kenneth M. Jaffe, MD, Director Ross M. Hays, MD Teresa L. Massagli, MD Kenneth M. Jaffe MD, Director Children’s and consultation at Harborview Medical Center. Clinical interests include care of children with multiple traumas, traumatic brain injury, spinal cord injury, limb deficiency, arthrogryposis and other neurological and neuromuscular disorders. His research interests include outcomes from pediatric trauma and brain injury, and management of arthrogryposis and pediatric pain. He has served as principal investigator and co-investigator on numerous research grants. He is editor-in-chief of Archives of Physical Medicine and Rehabilitation, the mostly highly cited journal in the rehabilitation sciences. He also serves on the editorial board of the journal Brain Injury. Ross M. Hays, MD, is medical director of the Pediatric Palliative Care Program at Seattle Children’s Hospital, professor in the Department of Rehabilitation Medicine and adjunct professor of pediatrics at the University of Washington School of Medicine; he is also a faculty associate in the Department of Biomedical History and Ethics. He attends in Seattle Children’s neurodevelopmental and rehabilitation medicine clinics and leads the inpatient pediatric rehabilitation consult service. He is board certified SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 197 Rehabilitation Medicine in pediatrics, rehabilitation medicine and hospice and palliative medicine. Dr. Hays has been principal investigator on a trial using botulinum toxin to improve function for children with cerebral palsy and co-investigator in a study of the efficacy of selective dorsal rhizotomy in the treatment of cerebral palsy. He has participated in research investigating pain and painful procedures in children and projects to improve education on chronic disease and disability. Dr. Hays is pediatric clinical core leader for the Seattle Cancer Care Alliance’s Muscular Dystrophy Cooperative Research Center, which provides care to children with severe life-limiting illness using a unique model that is highly regarded throughout the country. He also provides consultation on pediatric palliative care to hospitals regionally and nationally. Teresa L. Massagli, MD, is attending physician at Seattle Children’s hospital and professor of rehabilitation medicine and pediatrics at the University of Washington School of Medicine. She is board certified in pediatrics and in physical medicine and rehabilitation, and subspecialty certified in spinal cord injury medicine. Her clinical activities include inpatient rehabilitation and outpatient clinics at Seattle Children’s, regional outreach clinic in Bellingham, Wash., and consultative rehabilitation medicine at Fircrest School and Harborview Medical Center. She is also residency program director for physical medicine and rehabilitation at the University of Washington. Clinical interests include care of patients with spinal cord injury, traumatic brain injury and other neurological and neuromuscular disorders. Her research interests are in outcomes after traumatic brain injury and medical and rehabilitation issues in pediatric spinal cord injury. She is also interested in methods of evaluation of resident competence in graduate medical education. Teresa L. Massagli, MD Parker J. Palmer Courage to Teach Award, ACGME, 2005 New Jersey Medical School Excellence in Teaching Award, 2005 Listed in America’s Top Doctors, 2005 Listed in “Best Doctors 2005,” Seattle magazine TEACHING AND PRESENTATIONS Ross M. Hays, MD Alaska Native Health System Program in Palliative Care, May 2005 Kenneth M. Jaffe, MD Conflicts of Interest in Medical Publishing, Archives of Physical Medicine Rehabilitation Editorial Board, March 6, 2005 Teresa L. Massagli, MD Pediatric Traumatic Brain Injury, University of Washington, January 31, 2005 Effective Presentations, resident seminar, Department of Rehabilitation Medicine, University of Washington, March 21, 2005 Building Your Educator’s Portfolio, faculty development workshop, University of Washington, May 24, 2005 Using the 360-Degree Evaluation to Assess Resident Competence, New Jersey Medical School, June 7, 2005 Effective Presentations, New Jersey Medical School, June 7, 2005 AWARDS AND HONORS Ross M. Hays, MD Listed in “Best Doctors 2005,” Seattle magazine Kenneth M. Jaffe, MD Listed in America’s Top Doctors, 2005 Listed in “Best Doctors in America,” 2005 Listed in “Best Doctors 2005,” Seattle magazine 198 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Enhancing PM&R Resident Teaching Skills: Strategies in Clinical Precepting, and Enhancing PM&R Resident Teaching Skills: Giving Effective Feedback, New Jersey Medical School, June 8, 2005 The Neurological Examination, orientation seminar, Department of Rehabilitation Medicine, University of Washington, July 11, 2005 Rehabilitation Medicine Clinical Precepting Skills, seminar, Department of Rehabilitation Medicine, University of Washington, October 3, 2005 Strategies for Managing Fatigue, resident seminar, Department of Rehabilitation Medicine, University of Washington, November 7, 2005 Educator Portfolio Development, Department of Psychiatry, University of Washington, November 7, 2005 McLaughlin JF, Felix S. Nowbar S, Ferrel A, Bjornson K, Hays R. Lower extremity sensory function in children with cerebral palsy. Pediatr Rehab. 2005;8(1):45–52. Slomine BS, McCarthy ML, Ding R, MacKenzie EJ, Jaffe KM, Aitken ME, Durbin DR, Christensen JR, Dorsch AM. Healthcare utilization and needs following pediatric traumatic brain injury. Pediatrics. 2005; in press. PUBLICATIONS Ding R, McCarthy ML, Houseknecht E, Ziegfeld S, Knight VM, Korehbandi P, Parnell D, Klotz P, MacKenzie E, Durbin D, Paidas C, Aitken M, Jaffe KM, Slomine B, Dorsch A, Christensen J, Berk R. Health-related quality of life of children with an extremity fracture: a one year follow-up study. J Pediatr Orthop. 2005; in press. Engel JM, Kartin D, Jaffe KM. Exploring chronic pain in children with Duchenne muscular dystrophy: a model for pediatric neuromuscular disease. In: Carter, G, ed. Rehab Clin North Am. Philadelphia: Elsevier, 2005:1113–1124. Feudtner C, Larter N, Villareale BM, Sharp V, Hays R, Neff JM. Technology-dependency among patients discharged from a children’s hospital: a retrospective cohort study. BMC Pediatr. May 9, 2005;5:8. Hakimi KN, Massagli TL. Anterior spinal artery syndrome in two children with genetic thrombotic disorders. J Spinal Cord Med. 2005;28:69–73. Massagli TL, Knowles J. Special considerations for pediatric patients with disability due to trauma. In: Robinson LR, ed. Trauma Rehabilitation. Lippincott Williams & Wilkins, 2005:pp 291–312. McCarthy, ML, MacKenzie EJ, Durbin DR, Aitken ME, Jaffe KM, Paidas CN, Slomine BS, Dorsch AM, Berk RA, Christensen JR. The pediatric quality of life inventory: an evaluation of its reliability and validity for children with traumatic brain injury. Arch Phys Med Rehabil. 2005;86(10):1901–1909. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 199 Department of Surgery 200 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON The Department of Surgery consists of 29 full-time University of Washington School of Medicine faculty members who have devoted their practices to clinical excellence, innovation, surgical education and expanding research. Our surgeons are members of nine different divisions: Cardiothoracic Surgery, Craniofacial, Plastic and Reconstructive Surgery, General and Thoracic Surgery, Neurosurgery, Ophthalmology, Oral and Maxillofacial Surgery, Otolaryngology, Urology and Transplant Surgery. With fellowship training programs in five of these disciplines, we have consistently attracted top trainees from around the world. The spirit of innovation has characterized the Department of Surgery. A number of our faculty are internationally recognized for developing revolutionary pediatric Robert S. Sawin, MD Surgeon-in-Chief surgical techniques, including Dr. Michael Mitchell, Urology, for pioneering complete primary exstrophy reconstruction; Dr. Joseph Gruss, Craniofacial, Plastic and Reconstructive Surgery, for innovating surgical techniques for facial trauma and infant cleft; and Dr. John Waldhausen, General and Thoracic Surgery, for leadership in using minimally invasive surgical (MIS) techniques. Basic science laboratories are led by Dr. James Bassuk in the human urothelial biology lab, and by Dr. Stephen Kim, who focuses on tissue engineering of the intestine. Dr. Jonathan Perkins, Otolaryngology, performs collaborative translational research efforts with the vascular biology laboratory at the University of Washington School of Medicine. Dr. Kathleen Sie performs clinical research focused on childhood hearing loss in the Childhood Communication Center. Dr. Henry Ou investigates ototoxicity with a focus on otoprotection. Dr. Jeffrey Ojemann leads research funded by the National Institutes of Health (NIH) that focuses on functional MRI. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 201 Cardiothoracic Surgery The Division of Cardiothoracic Surgery (in the Department of Surgery) treats neonates, infants, children and teens with heart failure, coronary disease, structural defects and rhythm disturbances. We perform open and closed heart surgeries, specializing in one-stage corrective procedures. Surgical therapies include coronary artery bypass graft, heart valve repair and replacement, heart transplantation (including cardiac assist devices), electrophysiology, arrhythmia surgery and thoracic aorta repairs. We have a dedicated cardiac intensive care unit with state-of-the-art equipment and an exceptional nursing staff for all cardiac surgical patients. Areas of research include developing an implantable ventricular assist device for young children and studying intracellular energetics of myocites relating to pathophysiology of the failing heart using novel tools. TEACHING, RESEARCH AND CLINICAL EXPERTISE Gordon A. Cohen, MD, PhD, is chief of the Division of Cardiothoracic Surgery at Seattle Children’s Hospital and associate professor of pediatric cardiothoracic surgery at the University of Washington School of Medicine. He is co-director of Seattle Children’s Heart Center and holds the Sam and Althea Stroum Endowed Chair in Pediatric Cardiovascular Surgery. He received his medical degree from Tulane University School of Medicine; he earned an MS and a PhD in pharmacology from the University of California, Los Angeles. He completed residencies in cardiothoracic surgery at the University of Washington School of Medicine and in general surgery at UCLA Medical Center. He has been consulting cardiothoracic surgeon at the Great Ormond Street Hospital for Children in London and senior lecturer at the Institute of Child Health at University College London. His interests include complex neonatal repairs, pediatric heart and lung transplant, mechanical cardiac assistance and heart failure. He is conducting research on a pediatric ventricular assist device (VAD) program. 202 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Lester C. Permut, MD, is attending surgeon in pediatric cardiothoracic surgery at Seattle Children’s Hospital and associate professor in the Department of Surgery at the University of Washington School of Medicine. Dr. Permut received his MD from Boston University School of Medicine, and did postgraduate training at Beth Israel Hospital in Boston and University of California, Los Angeles Medical Center. He has completed the University of Washington’s Teaching Scholars program. He is director of education for the pediatric cardiac surgery program and cardiothoracic surgery lecturer for the anesthesia and pediatric ICU (Intensive Care Unit) fellowship programs. His clinical interests include pediatric cardiac surgery and complex congenital heart defects. AWARDS AND HONORS Gordon A. Cohen, MD Listed in “Best Doctors 2005,” Seattle magazine Cardiothoracic Surgery TEACHING AND PRESENTATIONS Gordon A. Cohen, MD, PhD Cardiac ECMO and Mechanical Cardiac Assist, AmSECT Pediatric Perfusion Meeting, 2005 annual meeting, July 2005 Lester C. Permut, MD Normal Cardiac Anatomy and Pathology of Congenital Heart Disease, pediatric critical care fellowship lectures, Seattle Children’s, 2005 Hoskote A, Cohen GA, Goldman A, Shekerdemian L. Tracheostomy in infants and children after cardiothoracic surgery: indications, risk factors and timing. J Thorac Cardiovasc Surg. Oct 2005;130(4):1086–1093. Jacobs JP, Elliott MJ, Anderson RH, Quintessenza JA, Chai PJ, Morell VO, Botero LM, van Gelder HM, Badhwar V, Kanani M, Cohen GA, Burke RP. Creating a database with cardioscopy and intraoperative imaging. Cardiology in the Young. 2005;15 (suppl 1) 184–189. Myocardial Protection in Cardiac Surgery and Surgery of CHD, pediatric critical care fellowship lecture, Seattle Children’s, 2005 Muzaffar AR, Ploplys EA, Stevenson JG, Cohen G, Permut LC. Direct microvascular repair of an infant’s transected coronary artery: case report. J Reconstr Microsurg. Nov 2005;21(8):547–550. PUBLICATIONS Ricci M, Cohen GA, Kocyildirim E, Khambadkone S, Elliott M. Arterial switch operation with quadricuspid pulmonary valve. Ann Thorac Surg. Apr 2005; 79(4):1428–1430. Balfour-Lynn IM, Abrahamson E, Cohen GA, Hartley J, King S, Parikh D, Spencer D, Thomson AH, Urquhart D (on behalf of the Pediatric Pleural Diseases Subcommittee of the BTS Standards of Care Committee). BTS guidelines for the management of pleural infection in children. Thorax. 2005;60:i1–i21. Choudhary AK, Sellars ME, Wallis C, Cohen GA, McHugh K. Primary spontaneous pneumothorax in children: the role of CT in guiding management. Clin Radiol. Apr 2005;60(4):508–511. Cohen GA, Permut LC. Decision making for mechanical cardiac assist in pediatric cardiac surgery. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2005;8:41–50. FACULTY Gordon A. Cohen, MD, PhD, Chief Lester C. Permut, MD Gordon A. Cohen MD, PhD, Chief SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 203 Craniofacial, Plastic and Reconstructive Surgery The Division of Craniofacial, Plastic and Reconstructive Surgery (in the Department of Surgery) provides a comprehensive range of plastic and craniofacial services for congenital and acquired conditions affecting infants, children and adolescents. Two of our surgeons are part of the multidisciplinary Craniofacial Center at Seattle Children’s Hospital, which treats children with cleft lip and palate and other craniofacial problems. The plastic surgeons play an integral role in the treatment of patients with cleft and craniofacial conditions and also help manage maxillofacial trauma, tumors and other developmental anomalies of the head and neck. The Plastic Surgical Clinic treats children with general plastic surgical issues such as skin and soft tissue tumors and abnormalities and other reconstructive problems. The plastic surgery program has recruited a third full-time surgeon, who will be arriving in September 2006, to provide needed services to our large patient load. TEACHING, RESEARCH AND CLINICAL EXPERTISE Joseph S. Gruss, MD, is chief of the Division of Craniofacial, Plastic and Reconstructive Surgery at Seattle Children’s Hospital and professor in the Department of Surgery at the University of Washington School of Medicine. He is the first holder of the Marlys C. Larson Endowed Chair in Pediatric Craniofacial Surgery. He earned his MD in Johannesburg, South Africa and completed general and plastic surgery training as well as a fellowship in head and neck oncological and craniofacial surgery. Dr. Gruss came to Seattle Children’s in 1991 to establish a state-of-the-art craniofacial surgical program; the Craniofacial Center is now the busiest program of its type in North America. Dr. Gruss has pioneered the application of craniofacial techniques to the care of facial trauma and the use of rigid internal fixation of the craniofacial skeleton. In addition he has pioneered numerous techniques in the field of infant cleft and craniofacial surgery. Dr. Gruss has supervised and trained fellows from all over the world and is a regular teacher in North America, Europe and the Far East. Loren H. Engrav, MD, is attending surgeon at Seattle Children’s Hospital and professor in the Department of Surgery at the University of Washington School of Medicine. He served as chief of the Division of Plastic Surgery from 1977 to 2001 and also attends at University of Washington Medical Center, Harborview Medical Center and the Veterans Affairs Puget Sound Health Care System hospital in Seattle. He does didactic and clinical teaching at the University of Washington. Dr. Engrav’s clinical interests include 204 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON acute and reconstructive burns and general plastic surgery. His research interests include hypertrophic scarring and wound healing. Richard A. Hopper, MD, is surgical director of the Craniofacial Center at Seattle Children’s Hospital and assistant professor in the Department of Surgery at the University of Washington School of Medicine. He received his MD from Memorial University of Newfoundland in St. John’s, Newfoundland and Labrador, Canada. Dr. Hopper’s clinical practice focuses on the surgical treatment of cleft lip and palate, craniosynostosis and rare and severe birth deformities of the bones and soft tissues of the face. He has worked to standardize a two-year CT scan protocol for patients undergoing cranial vault expansion for the treatment of craniosynostosis. The database now has 60 patients with complete data, and will increase at about 60 patients per year. Seattle Children’s also has the second-largest clinical database on external midface distraction in the country. Dr. Hopper and his colleagues have used this data to complete studies on generate bone formation, long-term 3D stability and psychosocial impact. Matthew B. Klein, MD, MS, is attending surgeon at Seattle Children’s Hospital and assistant professor of surgery at the University of Washington School of Medicine. He is associate program director for the plastic surgery residency program at the university. He earned his MD from Yale University and an MS in epidemiology from the University of Washington. Dr. Klein does didactic and clinical teaching and has hospital appointments at Seattle Children’s, University Craniofacial, Plastic and Reconstructive Surgery of Washington Medical Center, Harborview Medical Center, and the Veterans Affairs Puget Sound Health Care System hospital. Nicholas B. Vedder, MD, is attending surgeon at Seattle Children’s Hospital and chief of the Division of Plastic Surgery in the Department of Surgery at the University of Washington. He attends at Seattle Children’s, Harborview Medical Center, University of Washington Medical Center, Veterans Affairs Puget Sound Health Care System and Seattle Cancer Care Alliance. He is professor in the departments of Surgery and Orthopedics and in the Division of Plastic Surgery at the University of Washington. Dr. Vedder’s clinical and research interests include plastic and reconstructive surgery, hand surgery and reconstructive microsurgery. Symposium on Facial Reconstruction, Plastic Surgery Educational Foundation, Tucson, Ariz., February 2005 Management of Complex Craniofacial Trauma, visiting professor, University of Miami, February 2005 Cleft and Craniofacial Surgery, mini medical school, University of Washington, March 2005 Symposium on pediatric plastic surgery, Baylor College of Medicine, Houston, March 2005 Symposium on orbital surgery, Johns Hopkins University, Baltimore, April 2005 Visiting professor: University of Mississippi, Jackson, Miss., May 2005 Visiting professor: University of Montana and St. Patrick’s Hospital Postgraduate Symposium on Facial Trauma, Missoula, Mont., June 2005 AWARDS AND HONORS Joseph S. Gruss, MD Best Paper Award, Educational Foundation of American Society of Maxillofacial Surgery, 2005 TEACHING AND PRESENTATIONS Joseph S. Gruss, MD Differential Diagnosis of Abnormal Head Shape in Infants, Ralph Millard lecture, International Symposium on Pediatrics, Miami Children’s Hospital, January 2005 Management of Vascular Malformations in Kids and Adults, Northwest Society of Plastic Surgeons, Maui, Hawaii, February 2005 FACULTY Joseph S. Gruss, MD, Chief Loren H. Engrav, MD Richard A. Hopper, MD Matthew B. Klein, MD, MS Nicholas B. Vedder, MD Visiting professor: University of Cardiff, ACMF International Symposium on Orbital Surgery, Cardiff, UK, September 2005 Visiting professor: Stanford University, Management of Facial Fractures postgraduate course in plastic surgery, Palo Alto, Calif., October 2005 Differential Diagnosis of Abnormal Head Shape in Infants, visiting professor, University of Akron, Ohio, October 2005 Course chairman, ACMF advanced maxillofacial course, Portland, Ore., November 2005 Special honored lecturer, ACMF advanced maxillofacial course on facial trauma, Frankfurt, Germany, December 2005 Richard A. Hopper, MD Hopper RA, Kelley P. Use of a nasal “passenger” graft during Lefort III distraction in a child with MarshallStickler syndrome. American Cleft Palate-Craniofacial Association 62nd annual meeting, Myrtle Beach, S.C., April 2005 Joseph S. Gruss MD, Chief SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 205 Craniofacial, Plastic and Reconstructive Surgery Hopper RA, Lewis C, Starr J, Umbdenstock R. Outpatient cleft lip repair – should we do it? NWSPS annual meeting, Kapalua, Hawaii, February 2005 Hopper R, Kelley P, Gruss JS. Definitive care phase: maxillofacial injuries In: Surgery. Greenfield L, ed. 2005. Kelley PK, Cunningham M, Hing A, Sze R, Gruss JS, Ellenbogen RG, Hopper RA. Anterior plagiocephaly secondary to minor suture synostosis: clinical, diagnostic and therapeutic considerations. American Cleft Palate-Craniofacial Association 62nd annual meeting, Myrtle Beach, S.C., April 2005 Manning SC, Bloom DC, Gruss JS, et al. Diagnostic and surgical challenges in the pediatric skull base. Otolaryngol. Clin. North Am. Aug 2005;38:773–794. Kelley P, Hopper RA, Watts R. Temporal 3-D CT imaging of pterygomaxillary ossification following Lefort III distraction. American Cleft PalateCraniofacial Association 62nd annual meeting, Myrtle Beach, S.C., April 2005 Umbdenstock R, Hopper RA, Lewis C, Starr J, Fisher D. Complications within the first 24 hours following cleft lip repair: a justification for overnight admission. American Cleft Palate-Craniofacial Association 62nd annual meeting, Myrtle Beach, S.C., April 2005 Watts R, Hopper RA, Umbdenstock R, Lewis C, Starr J, Fisher D. Complications within the first 24 hours following cleft lip repair: a justification for overnight admission. Canadian Society of Plastic Surgeons 59th annual meeting, Nanaimo, Canada, June 2005 PUBLICATIONS Gruss JS. Foreword. In: Evaluation and Treatment of Orbital Fractures: A Multidisciplinary Approach. Holck DC, ed. Elsevier, 2005. Heike CL, Cunningham M, Gruss JS, et al. Skeletal changes in epidermal nervus syndrome: does ipsilteral involvement provide clues to the pathogenesis? Am J Med Genet. Dec 2005;139:67–77. Hopper RA, Gruss J. Trauma — definitive care phase: maxillofacial injuries. In: Surgery: Scientific Principles and Practice, 4th edition. Mulholland, Lillemoe, Doherty, Maier, Upchurch, eds. Philadelphia: Lippincott Williams & Wilkins, 2005;389–395. 206 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Perking JA, Lewis CW, Gruss JS, et al. Furlow palatoplasty for management of velopharyngeal insufficiency: A prospective study of 148 consecutive patients. Plast. Reconstr. Surg. July 2005;116:72–80. Ploplys E, Muzaffar A, Gruss JS, et al. Early definitive cranioplasty in infants with cutis aplasia of the scalp. Cleft Palate Craniofac J. July 2005; 42:442–447. Sze RW, Hopper RA, Ghioni V, Gruss JS, Ellenbogen RG, King D, Hing AV, Cunningham ML. MDCT imaging diagnosis of the child with posterior plagiocephaly. Am J Roentgenol. Nov 2005;185(5):1342–1346. Sze R, Gruss JS. Ultrasound screening of lambdoid suture. Year Book in Plastic Surgery, 2005. Zerr D, Ellenbogen RG, Gruss JS, et al. Surgical site infections following intracranial surgery for craniofacial malformations: frequency and risk factors. Neurosurg. April 2005;56:733–739. General and Thoracic Surgery The Division of General and Thoracic Surgery (in the Department of Surgery) includes dedicated pediatric surgeons who provide comprehensive care for infants and children with a wide variety of surgical conditions. The division’s patients range from newborns with birth defects to adolescents with problems that are best treated in a children’s hospital environment. Our faculty use less painful, less disfiguring surgical procedures, and they have advanced surgical skills, particularly with minimally invasive surgical techniques. Working with Seattle Children’s outstanding hematology and oncology program and with the bone marrow transplant program, the Division of General and Thoracic Surgery maintains a strong clinical and research interest in childhood cancer treatment. We also partner closely with Seattle Children’s nationally regarded nephrology and gastroenterology divisions, yielding a wealth of experience with patients who have end-stage organ failure and require preparation for organ transplantation and after-transplant care. Our basic research activity is focused on intestinal replacement using tissue engineering techniques. Surgical outcomes research, surgical oncology and organ transplantation are areas of significant scholarly activity. Surgical education and training is another important area of scholarship. Several of the division faculty are active in University of Washington School of Medicine programs for medical students. General surgery residents from training programs throughout the Puget Sound region rotate with our service, and we offer an ACGME-accredited fellowship training program in pediatric surgery. Graduates of our programs include many prominent faculty members at other universities and training programs, confirming our reputation as one of the top pediatric surgery programs in the country. TEACHING, RESEARCH AND CLINICAL EXPERTISE Robert S. Sawin, MD, is surgeon-in-chief at Seattle Children’s Hospital and vice chairman of the Department of Surgery in the University of Washington School of Medicine. He completed his residency at Harvard’s Brigham and Women’s Hospital and completed a fellowship at Seattle Children’s. Dr. Sawin helped establish the Children’s liver transplant program and ECMO (extracorporeal membrane oxygenation) program; in 1990 he performed the first FACULTY Robert S. Sawin, MD, Surgeon-in-Chief Adam B. Goldin, MD, MPH Patrick J. Healey, MD Stephen S. Kim, MD Daniel J. Ledbetter, MD John H.T. Waldhausen, MD Robert S. Sawin MD, Surgeon-in-Chief pediatric liver transplant in the Northwest with Dr. James Perkins, and he performed the region’s first ECMO cannulation. In addition to a clinical interest in pediatric liver and tumor surgery, Dr. Sawin developed a research interest in the biology of pediatric tumors. He is an active member of the national oncology cooperative, the Children’s Cancer Group, and has published many articles on subjects related to cancer surgery, including the treatment of neuroblastoma, sarcomas and Wilm’s tumor. He is a reviewer for the Journal of Pediatric Surgery. Dr. Sawin has been active in many regional, national and international surgical societies, and has served as secretary of the Pacific Association of Pediatric Surgeons and secretary treasurer of the North Pacific Surgical Association. Adam B. Goldin, MD, MPH, is pediatric surgeon at Seattle Children’s Hospital and assistant professor of surgery at the University of Washington School of Medicine. He received his MD from Rush Medical College of Rush University, Chicago. He completed his general surgery residency and clinical research fellowship at the University of Washington, and earned his MPH in epidemiology at the university School of Public SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 207 General and Thoracic Surgery Health. He also completed a pediatric surgery fellowship at Children’s Hospital of Wisconsin. Dr. Goldin cares for children in Seattle Children’s general and thoracic surgery clinics and has expertise and training in laparoscopic surgery. Specific areas of clinical interest include pediatric tumors, neonatal surgery and laparoscopic surgery. Specific areas of research interest include clinical outcomes and quality of care in pediatric surgery. Dr. Goldin believes in maintaining the highest standard of care throughout the scope of pediatric general and thoracic surgery. He believes in continual re-evaluation of surgical care delivery methods, with particular attention to individually and culturally sensitive delivery. Patrick J. Healey, MD, is chief of transplantation in the General and Thoracic Surgery Division at Seattle Children’s Hospital. Dr. Healey received his MD from the Boston University School of Medicine. He completed his general surgery residency at the Hartford Hospital and completed fellowship training in abdominal transplantation at the University of Washington and in pediatric surgery at Seattle Children’s. Dr. Healey has expertise and training in pediatric transplantation, specifically liver and kidney. His clinical and research interests include transplantation in infants and small children, neonatal surgery, congenital anomalies and pediatric tumors. Stephen S. Kim, MD, is attending surgeon at Seattle Children’s Hospital and assistant professor in the Department of Surgery at the University of Washington School of Medicine and adjunct assistant professor in the Department of Bioengineering. He received his MD from the University of Virginia School of Medicine. He completed his general surgery residency at the University of Chicago hospitals, his surgery research fellowship at Children’s Hospital Boston, and his pediatric surgery fellowship at Seattle Children’s. Dr. Kim attends and consults on the inpatient service and sees outpatients in the general and thoracic surgery outpatient clinics. His clinical interests include neonatal surgery, minimally invasive surgery and gastrointestinal diseases. His research interests include tissue engineering of the gastrointestinal tract. 208 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Daniel J. Ledbetter, MD, is attending surgeon at Seattle Children’s Hospital and associate professor in the Department of Surgery in the University of Washington School of Medicine. He is co-chair of the Wound Care Committee at Seattle Children’s. His interests include endocrine surgery, surgical critical care and ECMO — extracorporeal membrane oxygenation, a procedure in which an artificial heartlung machine takes over the work of the lungs, and sometimes also the heart. His interests also include neonatal surgery and general and thoracic surgery of infants and children. John H.T. Waldhausen, MD, is attending surgeon at Seattle Children’s Hospital and professor of surgery at the University of Washington School of Medicine. He is director of the pediatric surgery fellowship and of general surgery resident education at Seattle Children’s. Dr. Waldhausen’s primary research is in clinical outcomes. He also attends at Children’s Bellevue Clinic and at Seattle Children’s in the Division of Transplant Surgery. His clinical activities cover the broad range of pediatric surgery with a focus on minimally invasive surgery, congenital surgical problems and pediatric cancer surgery. AWARDS AND HONORS Daniel J. Ledbetter, MD Listed in America’s Best Doctors, 2005 Robert S. Sawin, MD Listed in “Best Doctors 2005,” Seattle magazine General and Thoracic Surgery TEACHING AND PRESENTATIONS Stephen S. Kim, MD Initial Nonoperative Management and Delayed Closure for Treatment of Giant Omphaloceles, 38th annual meeting of the Pacific Association of Pediatric Surgeons, Vancouver, BC, Canada, May 2005 Robotic Resection of a Choledochal Cyst, 91st Annual Clinical Congress of the American College of Surgeons, Pediatric Surgery Video Session, San Francisco, October 2005 Robert S. Sawin, MD Perinatal Management of Giant Omphalocele, Perinatal Conference, Evergreen Hospital Medical Center, Kirkland, Wash., June 2005 PUBLICATIONS Avansino J, Goldman B, Sawin RS, Flur DR. Primary operative vs. nonoperative therapy for pediatric empyema: a meta-analysis. Pediatr. 2005;115(6):1652–1659. Kim SS, Lau S, Lee S, Schaller RT, Healey PJ, Sawin RS, Ledbetter DJ, Waldhausen JHT. Pyloromyotomy: a comparison of laparoscopic, circumumbilical, and right upper quadrant techniques. J Am Coll Surg. 2005;201:66–70. Kim SS, Lau S, Lee S, Waldhausen JHT. The learning curve for laparoscopic pyloromyotomy. J Laparoendosc Adv Surg Tech. 2005;15:474–477. Lau ST, Kim SS, Ledbetter DJ, Healey PJ. Fraternal twins with Morgagni hernias: a case report. J Pediatric Surgery. April 2005;40(4):725–727. Lau ST, Kim SS, Lee SL, Ledbetter DJ. The anomalous spenic vein: a case report and review of the literature. J Pediatr Surg. Sep 2005;40(9):1492 Waldhausen JHT. Surgical management of gastroschisis. Neoreviews. 2005;6:e1–e7. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 209 Neurosurgery The Division of Neurosurgery (in the Department of Surgery) provides inpatient and outpatient surgical services for patients from infancy through adolescence. Neurosurgery staff work closely with many medical and surgical specialties at Seattle Children’s Hospital, consulting with colleagues in anesthesia, pediatric surgery, neurology, physical medicine and rehabilitation and the Craniofacial Center. Using advanced equipment and techniques, division physicians and staff successfully diagnose unsuspected diseases and surgically treat congenital malformations of the central nervous system. We treat conditions including craniofacial deformities, brain tumors, congenital abnormalities of the head and spine, hydrocephalus, intractable seizures, neural tube defects, spasticity, trauma and tumors of the nervous system. With brain tumors as the deadliest and second-most common type of childhood cancer, the doctors, nurses and staff of the Division of Neurosurgery face a unique set of concerns when caring for their patients. Children fighting brain tumors need comprehensive care before, during and after surgery. Division staff provide compassionate, expert bedside care and work tirelessly to deliver the latest advances in medicine, whether in a routine follow-up appointment or during an emergency visit. Neurosurgery staff focus not only on the children, but also on their futures. Alongside engineers, oncologists and radiologists, our neurosurgeons are working to develop tiny molecules called nanoparticles that will one day be delivered directly to a brain tumor to help treat it. When inserted into cells, these nanoparticles will be visible on an MRI scan and will enable doctors to detect tumors and differentiate between cancerous and normal cells. Early detection, combined with better visibility in the operating room, will allow surgeons to remove tumors without damaging a growing child’s healthy brain tissue. Our physician scientists work daily to improve the odds for children with brain tumors. TEACHING, RESEARCH AND CLINICAL EXPERTISE Richard G. Ellenbogen, MD, is chief of the Division of Neurosurgery and fellowship director of pediatric neurological surgery at Seattle Children’s Hospital; he holds the Theodore S. Roberts Endowed Chair in Pediatric Neurosurgery. He is professor in the Department of Neurological Surgery and adjunct professor of radiology at the University of Washington School of Medicine and serves as chairman of the Department of Neurological Surgery. He is active on many Seattle Children’s committees and has served as president of the Congress of Neurological Surgery. He has been involved with the American Society of Pediatric Neurological Surgery and is an active member of the American Association of Neurological Surgeons. Dr. Ellenbogen serves as director and instructor for the Cerebral Vascular Anastomosis Laboratory of the Congress of Neurological Surgeons, and has served as an instructor at the Foundation and Uniformed Services University of the Health Sciences 210 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON (USUHS). He served in the US Army, attaining the rank of Lieutenant Colonel, and received the Bronze Star, the Meritorious Service Medal, the National Defense Service Medal and the Army Reserve Medal. Dr. Ellenbogen has editorial duties on several journals. He has published three books, including Clinical Neurosurgery and Principles of Neurosurgery, a basic textbook of neurological surgery. He has authored numerous articles, book chapters and presentations. Anthony M. Avellino, MD, is program director for neurosurgery education at Seattle Children’s Hospital. He is associate professor of neurological surgery and director of the neurosurgery residency program at the University of Washington School of Medicine; he also serves as joint assistant professor of orthopedics and sports medicine. He received his MD and completed a research fellowship at Colombia University College of Physicians and Surgeons in New York. He completed his residency in neurosurgery and two research fellowships at the University of Washington. Dr. Avellino is Neurosurgery a fellow in the American College of Surgeons and an active member of the American Society of Pediatric Neurosurgeons, American Association of Neurological Surgeons, Congress of Neurosurgeons, and Society for Research into Hydrocephalus and Spina Bifida. He serves as an editorial board member for the journals Pediatric Neurosurgery and Cerebrospinal Fluid Research. Dr. Avellino has directed two courses on neuro-endoscopy for residents and faculty. His research interests focus on investigations in the pathophysiology of hydrocephalus using proteomic and genomic techniques, as well as investigations in how complementary and alternative medicine may influence pediatric neurosurgical care. Dr. Avellino is widely published and frequently serves as a guest lecturer. Jeffrey G. Ojemann, MD, is director of epilepsy surgery at the Pediatric Epilepsy Center at Seattle Children’s Hospital and associate professor of neurological surgery at the University of Washington School of Medicine. He is Richard G. Ellenbogen Chair in Pediatric Neurosurgery at Seattle Children’s and research affiliate at the university Center on Human Development and Disability. He earned his MD and completed a fellowship in pediatric neurosurgery at Washington University School of Medicine in St. Louis; he served as epilepsy surgery fellow at the University of Washington. Dr. Ojemann is extensively involved in research, with current interests including functional MRI in children, imaging cerebellar white matter tracts, visual effects of cerebellar lesions, brain wave correlates of motor, visual and cognitive behavior, computational models of brain signals, localization of epilepsy with novel brain imaging and localization of epilepsy with high-density EEG techniques. FACULTY Richard G. Ellenbogen, MD, Chief Anthony M. Avellino, MD Jeffrey G. Ojemann, MD Dr. Ojemann is preceptor for the Epilepsy Foundation Post-Doctoral Fellowship. He has served as ad hoc reviewer for several journals. He is widely published and is a frequent lecturer. AWARDS AND HONORS Jeffrey G. Ojemann, MD Listed in “Best Doctors in America,” 2005 TEACHING AND PRESENTATIONS Anthony M. Avellino, MD Symptomatic Cerebellar Tonsillar Ectopia in Patients with Lipomyelomeningocele, 49th Annual Scientific Meeting of the Society for Research into Hydrocephalus and Spina Bifida, Barcelona, Spain, 2005 Pediatric Cervical Spine Surgery Using the Intraoperative CT Scanner and Smaller NonTraditional Screws and Plates, Annual Meeting of the American Association of Neurological Surgeons, San Francisco, 2006 Neural Tube Defects, neurosurgery resident teaching conference, University of Washington, January 11, 2005 Neural Tube Defects, Surgical Embryology Conference, Seattle Children’s, April 21, 2005 Complex Pediatric Cervical Spine Surgery Using Intra-Operative CT Scanner, Washington State Association of Neurological Surgeons annual meeting, Seattle, May 14, 2005 Pediatric Hydrocephalus: History, Endoscopy, and Innovative Treatment, St. Francis Hospital Pediatric Section meeting, Federal Way, Wash., June 13, 2005 Richard G. Ellenbogen, MD Weill Medical College of Cornell University, New York, August 2005 Richard G. Ellenbogen MD, Chief SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 211 Neurosurgery Jeffrey G. Ojemann, MD Brain Surgery for Seizures, Grand Rounds, Sacred Heart Children’s Hospital, Spokane, Wash., August 24, 2005 Pediatric Brain Tumors, Grand Rounds, Walla Walla General Hospital, Walla Walla, Wash., September 20, 2005 PUBLICATIONS Altay EE, Fessler AJ, Gallagher M, Attarian HP, Dehdashti F, Vahle VJ, Ojemann JG, Dowling JL, Gilliam F. Correlation of severity of FDG-PET hypometabolism and interictal regional delta slowing in temporal lobe epilepsy. Epilepsia. 2005; 46(4):573–576. Ashley WA, Ojemann JG, Park TS, Wippold FJ. Primary hypothyroidism in a 12-year-old girl presenting as a suprasellar mass: rapid regression after initiation of thyroid replacement therapy. J Neurosurg (Pediatrics 4). 2005;102:413–416. Avellino AM. Hydrocephalus. In: Treatment of Pediatric Neurologic Disorders. Singer HS, Kossoff EH, Hartman AL, Crawford TO, eds. Boca Raton, Fla.: Taylor & Francis Group, 2005:25–36. Avellino AM, Carson BS. Increased intracranial pressure. In: Current Management in Child Neurology, 3rd ed. Maria BL, ed. New York: B.C. Decker, Inc., 2005: 563–568. Avellino AM, Mann FA, Grady MS, Chapman JR, Ellenbogen RG, Alden TD, Mirza SK. The misdiagnosis of acute cervical spine injuries and fractures in infants and children: the 12-year experience of a level I pediatric and adult trauma center. Child’s Nervous System. 2005;21:122–127. Baciu MV, Watson JM, Maccotta L, McDermott KB, Buckner RL, Gilliam FG, Ojemann JG. Evaluating functional MRI procedures for assessing hemispheric language dominance in neurosurgical patients. Neuroradiology. 2005;47:835–844. 212 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Bobola MS, Silber JR, Ellenbogen RG, Geyer JR, Blank A, Goff RD. O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines. Clin Cancer Res. 2005;11:2747–2555. Bolger WE, Tadros M, Ellenbogen RG, Judy K, Grady MS. Endoscopic management of cerebrospinal fluid leak associated with the use of bone wax in skull-base surgery. Otolaryngol Head Neck Surg. 2005;132:418–420. Cirak B, Horska A, Barker PB, Burger PC, Carson BS, Avellino AM. Proton magnetic resonance spectroscopic imaging in pediatric pilomyxoid astrocytoma. Child’s Nervous System. 2005;21:404–409. Hussain NS, Wang PP, James C, Carson BS, Avellino AM. Distal ventriculoperitoneal shunt failure caused by silicone allergy: case report. Journal of Neurosurgery. 2005;102:536–539. McDermott KM, Watson JM, Ojemann JG. Pre-surgical language mapping. Curr Dir Psychol Sci. 2005;14:291–295. Ojemann JG, McKinstry RC, Mukherjee P, Park TS, Burton H. Hand somatosensory cortex activity following selective dorsal rhizotomy: report of three cases with fMRI. Child’s Nervous System. 21:115–121. Veenstra TD, Conrads TP, Hood BL, Avellino AM, Ellenbogen RG, Morrison RS. Biomarkers: mining the biofluid proteome. Molecular and Cellular Proteomics. 2005;4:409–418. Wang PP, Avellino AM. Hydrocephalus in children. In: Principles of Neurosurgery, 2nd ed. Rengachary SS, Ellenbogen RG, eds. London: Elsevier Science, 2005:117–135. Yeung LC, Cunningham ML, Allpress AL, Gruss JS, Ellenbogen RG, Zerr DM. Surgical site infections after pediatric intracranial surgery for craniofacial malformations: frequency and risk factors. Neurosurgery. 2005 Ophthalmology The Division of Ophthalmology (in the Department of Surgery) works in conjunction with other specialists to provide the full spectrum of medical and surgical treatment options for eye diseases in childhood. The division includes an outpatient clinic, visual sensory laboratory and ocular motor laboratory. Our Eye Clinic is staffed by full-time pediatric ophthalmologists, residents from the University of Washington and ophthalmic technicians who are dedicated to providing high-level, comprehensive care for infants and children with eye problems. The Ophthalmology Clinic provides standard eye evaluations and consultations for children with complex ocular or medical problems. Diagnostic evaluations, by a team of clinicians and vision scientists, employ state-of-the-art technology. Behavioral testing and visual evoked potential are used to assess vision in preverbal infants or nonverbal children. Electroretinograms (ERGs) probe function of the macula and retina while confocal microscopy provides corresponding anatomic details about these structures in children with retinal diseases. Visual field testing and transient visual evoked potentials measure optic nerve function and supply information about cortical processing of visual inputs to the brain. Children with strabismus and eye movement abnormalities receive the benefit of eye muscle imaging technology and quantitative analysis of their eye movements. The division’s accomplishments include advanced color visual evoked potential in evaluation of childhood retinal diseases of the macula, advances in confocal retinal imaging in children without needing eye drops to dilate the pupil, and predictions of visual outcome in infants born with optic nerve hypoplasia. Our research provides valuable information for the care of our patients and our ability to communicate with the family about the underlying problems of their child’s vision disability. TEACHING, RESEARCH AND CLINICAL EXPERTISE Avery H. Weiss, MD, is chief of the Division of Ophthalmology at Seattle Children’s Hospital and assistant professor of ophthalmology at the University of Washington School of Medicine. His clinical interests include visual disorders, eye movement abnormalities, cataract and glaucoma, retinoblastoma and orbital tumors, ocular malformations and FACULTY Avery H. Weiss, MD, Chief John P. Kelly, PhD James O. Phillips, PhD ophthalmological manifestations of systemic diseases, especially genetic, neurologic, rheumatic and craniofacial disorders. His research focuses on three areas: 1) assessment of optic nerve and visual cortical function in infants with optic nerve and brain malformations, visual pathway tumors, amblyopia and cortical visual impairment; 2) eye movements in normal children and children with brain tumors, malformations, injuries, autism and nystagmus, and characterization of abnormalities of the oculomotor plant in craniofacial disorders; and 3) assessment of macular development, probing local retinal function and development of retinal imaging techniques to study congenital and genetic retinal diseases. He has served on the editorial board of EyeNet and as a medical consultant for ABC News, and he has been ad hoc reviewer for 14 journals. He is an active member of the Children’s Oncology Group and several other pediatrics and ophthalmology associations. Avery H. Weiss MD, Chief SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 213 Ophthalmology John P. Kelly, PhD, is a research assistant professor at Seattle Children’s Hospital and adjunct research assistant professor at the University of Washington School of Medicine. He completed a postdoctoral fellowship at the University of Washington. He is responsible for clinical electrophysiology and clinical testing in pediatric patients. His interests include application of signal processing algorithms for objective measurement of visual responses, brain adaptations during treatment of amblyopia, retinal imaging by scanning laser ophthalmoscopy, prognostic research of cortical visual impairment and cortical blindness, optic pathway tumors, optic nerve diseases and other common pediatric vision disorders. His interests also extend to development of advances in technology; he is consultant to the human interface lab in the College of Engineering at the University of Washington. James O. Phillips, PhD, is researcher at Seattle Children’s Hospital and research associate professor in the Department of Otolaryngology–Head and Neck Surgery at the University of Washington. His focus is translational research, taking innovations in basic neurophysiology and genetics and applying them to the diagnosis and treatment of clinical disorders in children. The clinical oculomotor laboratory (COL) is a result of this interest. The COL is a first-class clinical and research laboratory created through collaboration between basic scientists and clinicians at Seattle Children’s and the University of Washington. The COL uses innovations from testing in non human primates and adult patients at the University of Washington to guide the development of testing in pediatric patients. In addition, the COL is used for basic scientific inquiry into the neural mechanisms underlying pediatric disorders. With his colleagues, Dr. Phillips is studying the mechanisms and progression of pediatric vestibular disorders associated with congenital hearing loss, such as Usher syndrome, and the basic cerebellar mechanisms potentially underlying autism. TEACHING AND PRESENTATIONS John P. Kelly, PhD Development of Acuity in Infants with Motor Versus Visual-Sensory-Associated Nystagmus, annual meeting of the Association for the Research in Vision and Ophthalmology, Fla. Light Measurement and Human Visual Electrophysiology, basic sciences lectures, University of Washington, September 2005 Visual Electrophysiology: The Electroretinogram, basic sciences lecture, University of Washington, October 2005 James O. Phillips, PhD Vestibular and Oculomotor Function in Pediatric Patients with Posterior Fossa Tumors, Oto-HNS Alumni Day, 2005 Laboratory Vestibular Testing, Advanced Temporal Bone Lab, 2005 Disequilibrium and the Ear: I’m Not Dizzy, I Just Fall Down, Seattle, Wash., 2005 Ears: Hearing and Beyond, Seattle, Wash., 2005 Avery H. Weiss, MD Analysis and Treatment of Hypertropia in Plagiocephaly, annual meeting for the Association for Research in Vision and Ophthalmology, Ft. Lauderdale, Fla., May 2, 2005 Eye Movement Disorders in Craniosynostosis, craniofacial research seminar, Seattle Children’s, August 22, 2005 Management of Difficult Strabismus Problems, Pediatric Subspecialty Day program, American Academy of Ophthalmology annual meeting, Chicago, 2005 AWARDS AND HONORS Avery H. Weiss, MD Listed in “Best Doctors 2005,” Seattle magazine 214 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Ophthalmology Activities at Seattle Children’s, Alec Matthew Schuldt Guild luncheon and silent auction, Seattle, November 20, 2005 Ophthalmology PUBLICATIONS Fuchs AF, Ling L, Phillips JO. Behavior of the PVP interneurons of the vestibulo-ocular reflex during head-free gaze shifts in the monkey. J Neurophysiol. 2005;94(6):4481–4490. Phillips JO, Noto C, Ibarreta M, Robinson FR. Context dependence of human and nonhuman primate saccade adaptation. Soc Neurosci. 2005;859:7. Robinson FR, Phillips JO, Weiss AH. Animal oculomotor data illuminate cerebellum-related eye movement disorders. In: Animal Models of Movement Disorders. LeDoux MS, ed. Academic Press, Elsevier, 2005. Street VA, Kallman JC, Robertson NG, Kuo SF, Morton CC, Phillips JO. A novel DFNA9 mutation in the VWFA2 domain of COCH alters a conserved cysteine residue and intrachain disulfide bond formation resulting in progressive hearing loss and site-specific vestibular and central oculomotor dysfunction. Am J of Med Genetics. 2005;139(2):86–95. Weiss, AH. Ocular abnormalities in childhood metabolic disorders. In: Harley’s Pediatric Ophthalmology (major revision), Nelson L, ed. Philadelphia: WB Saunders Co., 2005:448–475. Weiss AH, Sze R, Phillips JO. Analysis and treatment of hypertropia in plagiocephaly. Invest Ophthalmol Vis Sci. 2005;46:2352. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 215 Oral and Maxillofacial Surgery The Division of Oral and Maxillofacial Surgery (in the Department of Surgery) specializes in the surgical treatment of congenital and acquired conditions of the jaws, teeth and face. We provide a range of inpatient and outpatient services, including surgical correction of jaw deformity, cleft lip and palate and craniofacial abnormalities and maxillofacial trauma due to infection and pathology. We also offer minor oral surgery for medically compromised children. Our staff has extensive experience caring for children of all ages with disabling conditions. Prior to surgical reconstructions, we work closely with orthodontists and other surgeons to improve facial function and appearance by creating facial symmetry, properly aligning the jaws and ensuring proper placement of teeth. Our clinical research focuses on facial growth, distraction osteogenesis and cleft care. TEACHING, RESEARCH AND CLINICAL EXPERTISE Mark A. Egbert, DDS, is chief of the Division of Oral and Maxillofacial Surgery (OMS) at Seattle Children’s Hospital and associate professor of OMS at the University of Washington School of Medicine. He served as chief of OMS trauma services and the Dental Department at Harborview Medical Center for 12 years. Dr. Egbert received his dental and OMS training at the University of Washington and spent one year studying OMS at the Gemmente Ziekenhuis, Arnhem, The Netherlands. His particular interests include the biological basis of facial growth and development, the management of cleft lip and palate, applications of distraction osteogenesis in the correction of facial anomalies and the treatment of pediatric oral and maxillofacial pathology. Dr. Egbert serves on numerous review boards for journals, including the International Journal of Oral and Maxillofacial Surgery, American Journal of OMS and Triple O. His professional society memberships include the AAOMS and ACPA, and he FACULTY Mark A. Egbert, DDS, Chief Mark A. Egbert DDS, Chief 216 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON has served as president of the Western Society of OMS and the Washington State Society of OMS. He chairs and serves on committees of the American Association of OMS. He has served on the examining committee of the American Board of Oral and Maxillofacial Surgery. PUBLICATIONS Rafferty KL, Sun Z, Egbert MA, Baird EE, Herring SW. Mandibular mechanics following osteotomy and appliance placement II: Bone strain on the body and condylar neck. J Oral Maxillofac Surg. Apr 2006;64(4):620–627. Rafferty KL, Sun Z, Egbert MA, Herring SW. Mandibular mechanics after osteotomy and distraction appliance placement I: Postoperative mobility of the osteotomy site. J Oral Maxillofac Surg. Apr 2006; 64(4):610–619. Otolaryngology The Division of Otolaryngology (in the Department of Surgery) manages the complete spectrum of pediatric otolaryngologic disorders including hearing and speech problems, tonsil disease and sleep apnea, head and neck masses including thyroid disease and cancer, upper airway obstruction and voice problems. The division comprises five pediatric otolaryngologists. The division is closely associated with the Childhood Communication Center, which brings together staff from audiology, the cochlear implant team, education, genetics, pediatrics, psychiatry and speech language services to provide multidisciplinary care to children with communication needs. Division members also participate in the Craniofacial Center to serve children with cleft lip and palate and other craniofacial disorders. The division has several subspecialty clinics. The Hearing Loss Clinic provides a multidisciplinary evaluation of children with hearing problems. The Vascular Anomalies Clinic treats children with birthmarks ranging from port wine stains to large vascular tumors. Other specialty clinics include Complex Airway Clinic, Voice Clinic, Microtia Clinic, Velopharyngeal Insufficiency Clinic and Chronic Sinusitis Clinic. The division is closely affiliated with the University of Washington and the Virginia Merrill Bloedel Hearing Research Center in its research efforts. In addition, the division supports basic science research with lymphatic malformations. Ongoing research projects include speech processing for young cochlear implant recipients, gene mapping for vasculogenesis in vascular anomalies, immunologic profiling in chronic sinusitis patients, outcomes with speech surgery and ototoxicity. The Division of Otolaryngology is involved in training otolaryngology residents from the University of Washington and Madigan Army Medical Center. We offer a one-year clinical fellowship in pediatric otolaryngology. Fellows may also pursue a second year of research funded by the University of Washington Department of Otolaryngology NIH Training Grant. TEACHING, RESEARCH AND CLINICAL EXPERTISE Scott C. Manning, MD, is chief of the Division of Otolaryngology at Seattle Children’s Hospital and professor in the Department of Otolaryngology at the University of Washington School of Medicine. He is president of the Northwest Academy of Otolaryngology. Dr. Manning earned his MD from FACULTY Scott C. Manning, MD, Chief Andrew F. Inglis Jr., MD Jonathan A. Perkins, DO Kathleen C.Y. Sie, MD Scott C. Manning MD, Chief Tulane Medical School, completed his residency at University of Texas Southwestern Medical Center at Dallas, and did a fellowship in pediatric otolaryngology with Charles Bluestone and Sylvan Stool in Pittsburgh. He served as chief of pediatric otolaryngology at Parkland Hospital and Dallas Children’s Hospital. Dr. Manning’s clinical interests are pediatric sinusitis, chronic ear disease and vascular anomalies. Andrew F. Inglis Jr., MD, is attending physician and surgeon at Seattle Children’s Hospital and associate professor in the Department of Otolaryngology at the University of Washington School of Medicine. He received his MD from the Medical College of Pennsylvania, completed his residency in general surgery at Virginia Mason Hospital in Seattle, and completed a second residency in the Department of Otolaryngology at the University of Washington. He completed a one-year fellowship in pediatric otolaryngology at Seattle Children’s, including a four-month pediatric otolaryngology fellowship at the Royal Alexandria Hospital for Children in Sydney, Australia. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 217 Otolaryngology His clinical interests are pediatric airway problems and otitis media. Scott C. Manning, MD Listed in “Best Doctors 2005,” Seattle magazine Jonathan A. Perkins, DO, is otolaryngologist at Seattle Children’s Hospital and associate professor in the Department of Otolaryngology at the University of Washington School of Medicine. Dr. Perkins earned his DO at the University of Osteopathic Medicine and Health Sciences, did his residency training in otolaryngology at Madigan Army Medical Center in Fort Lewis, Wash., and obtained a pediatric fellowship at Seattle Children’s and the University of Washington. While practicing all aspects of pediatric otolaryngology, his primary research interests are communication disorders and vascular anomalies of the head and neck. Kathleen C.Y. Sie, MD Resident Research Teaching Award, University of Washington, Department of Otolaryngology, 2005 Kathleen C.Y. Sie, MD, is director of the Childhood Communication Center at Seattle Children’s Hospital and associate professor in the Department of Otolaryngology at the University of Washington School of Medicine. She developed the Childhood Communication Center in 2002 to optimize the multidisciplinary care available to children with complex communication needs. She also participates in the Craniofacial Center. She earned her MD from the University of Michigan Medical School, completed a residency in otolaryngology and a fellowship in auditory research at the University of Washington and completed a clinical fellowship in pediatric otolaryngology at Children’s Hospital Boston. Her clinical efforts are focused on communication issues of childhood. She directs the Hearing Loss Clinic and co-directs the Cochlear Implant Program. Dr. Sie performed the first cochlear implant at Seattle Children’s in 1994, and performed all of Children’s cochlear implants until 2005. She also works with speech language pathologists in the evaluation and management of children with velopharyngeal insufficiency (VPI), and she works with colleagues to perform complex auricular reconstruction using autologous tissue and on prosthetic management of microtia. Her research efforts have focused on surgical outcomes in VPI management and epidemiological studies on pediatric cochlear implantation. AWARDS AND HONORS Andrew F. Inglis Jr., MD Listed in “Best Doctors 2005,” Seattle magazine 218 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Listed in “Best Doctors 2005,” Seattle magazine TEACHING AND PRESENTATIONS Andrew F. Inglis Jr., MD Posterior Glottic Stenosis and Endoscopic Repair, University of Iowa Carver College of Medicine, Iowa City, April 2005 Persistent Thyroglossal Duct Cysts: An Institution’s Experience and New Method of Management, American Society of Pediatric Otolaryngology, Las Vegas, May 2005 Scott C. Manning, MD Update on Management of Vascular Anomalies in the Pediatric Age Group, Pediatric Sinusitis, Endoscopic Repair of Posterior Glottic Stenosis; Update of Laryngomalacia Management; 73rd Mid-Winter Clinical Conference, Research Study Club of Los Angeles, January 21–22, 2005 Laryngomalacia, University of Colorado Mid-Winter Meeting, Vail, Colo., February 1–3, 2005 Otolaryngology Considerations in Management of Autoimmune Airway Disease, Pediatric Endocrine Team Conference, Seattle Children’s, February 4, 2005 Airway Decision Making, Otolaryngology Resident Conference, University of Washington, April 20, 2005 Oral Board Exam Review, Otolaryngology Resident Conference, University of Washington, May 4, 2005 Pediatric Sinusitis, Pacific Coast OtolaryngologyOphthalmology Society, Irvine, Calif., June 25, 2005 Pediatric Sinusitis, Allergic Fungal Sinusitis, Laryngomalacia, University of Wisconsin Otolaryngology Update, Beaver Creek, Colo., July 22–25, 2005 Otolaryngology Vascular Anomalies (mini-seminar) moderator, American Academy of Otolaryngology–Head and Neck Surgery annual meeting, Los Angeles, September 27, 2005 Lymphatic Malformations, Vascular Anomaly Study Group, New York Presbyterian Hospital, New York, December 10, 2005 Pediatric Sinusitis, Providence Family Practice Infectious Disease Seminar, Seattle, December 16, 2005 Jonathan A. Perkins, DO Third Annual Craniofacial Lectureship, University of Mississippi, Jackson, Miss., April 2005 Current Treatment Challenges in Vascular Anomalies, American Society of Pediatric Otolaryngology, Las Vegas, May 2005 The Role of the Otolaryngologist in the Management of Vascular Anomalies (mini-seminar), American Academy of Otolaryngology–Head and Neck Surgery annual meeting, Los Angeles, September 2005 Second Workshop of Vascular Anomalies: Diagnosis and Treatment, Medical University of Gdansk, Gdansk, Poland, November 2005 PUBLICATIONS Bloom DC, Christenson TE, Manning SC, Eksteen EC, Perkins JA, Inglis AF, Stool SE. Plastic laryngeal foreign bodies in children: a diagnostic challenge. Inter J Pediatr Otorhinolaryngol. 2005;69:657–662. Chinn K, Brown OE, Manning SC. Effects of inhalant anesthesia: tympanometry validation (R98/217). Inter J Pediatr Otorhinolaryngol. 2005;69(2):187–192. Harsha WJ, Perkins JA, Lewis C, Manning SC. Head and neck endocrine surgery in children: 1997 and 2000. Arch Otolaryngol Head Neck Surg. 2005;131:564–570. Manning SC. Sinusitis. In: Conn’s Current Therapy 2005. Elsevier, Inc., 2005:234–236. Manning SC. Use of SLSE after endoscopy sinus surgery in children should be strictly limited. Arch Otolaryngol Head Neck Surg. 2005;131(3):269–270. Manning SC, Inglis AF, Mouzakes J, Carron J, Perkins JA. Laryngeal anatomic differences in pediatric patients with severe laryngomalacia. Arch Otolaryngol Head Neck Surg. 2005;131(4):340–343. Perkins JA, Lewis CW, Gruss J, Eblen L, Sie K. Furlow palatoplasty for the management of VPI: results of 148 consecutive patients. Plastic Reconstr Surg. 2005;116(1):72–80. Perkins JA, Sidhu M, Manning SC, Ghiono V, Sze R. Three-dimensional CT angiography imaging of vascular tumors of the head and neck. Inter J Pediatr Otorhinolaryngol. 2005;69(3):319–325. Shikowitz MJ, Abramson AL, Steinberg BM, DeVoti J, Bonagura VR, Mullooly V, Nouri M, Ronn AM, Inglis AF, McClay J, Freeman K. Clinical trial of photodynamic therapy with meso-tetra (hydroxyphenyl) chlorin for respiratory papillomatosis. Arch Otolaryngol Head Neck Surg. 2005;131(2):99–105. Sidhu MK, Perkins JA, Shaw DWW, Bittles MA, Andrews RT. Ultrasound-guided endovenous diode laser in the treatment of congenital venous malformation: preliminary experience. J Vasc Inter Radiol. 2005;16:879–884. Stern RE, Yueh B, Norton SJ, Lewis CW, Sie K. Recent epidemiology of pediatric cochlear implantation in the United States: disparity among children of different ethnicity and socioeconomic status. Laryngoscope. 2005;115(1):125–131. Thomas RF, Hornung RL, Manning SC, Perkins JA. Hemangiomas of infancy: treatment of ulceration in the head and neck. Arch Facial Plast Surg. 2005;7:312–315. Harsha W, Lewis C, Manning SC, Perkins JA. Pediatric admissions and procedures for lymphatic malformations in the United States: 1997 and 2000. Lymphat Res Biol. 2005;2(3). SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 219 Transplant Surgery The Division of Transplant Surgery (in the Department of Surgery) at Seattle Children’s Hospital, which offers comprehensive care to patients with end-stage disease of the intestine, liver and kidneys, is the only pediatric intestinal transplant program in the Northwest. Solid organ transplantation is the treatment of choice for end-stage organ disease in children. We provide consultation, diagnosis, treatment and management for end-stage organ failure with skilled teams of health care professionals focusing on the needs of our patients and families. A candidate’s team includes the appropriate members from our staff of doctors — board-certified pediatric hepatologists, gastroenterologists, nephrologists, surgeons and transplant surgeons — and pediatric nurses specially trained in the care of transplant patients and dietitians. We assist our pediatric transplant candidates and their families before, during and after organ transplantation, providing physical, emotional and financial support for the life-changing experience of transplantation. We use advanced technologies and the most current treatment protocols, including state-of-the-art interventional radiological procedures, for improved diagnosis, care, management and recovery. We also provide assistance in accessing and coordinating financial resources. Educating patients and their families is a critical component of our care. We teach them to monitor and to administer anti-rejection medications and to recognize signs of infections or rejection. We also help them return to a normal lifestyle, and provide education to patients’ school staff as well as other physicians and care providers. We conduct psychosocial evaluations and follow-up and offer directions to patient and family support groups. We care for children at our Liver Center and we are developing an Intestinal Rehabilitation Clinic for the care of children with diseases of the intestine requiring Total Parental Nutrition (TPN). Another way we advance treatment is by conducting clinical research trials of new medications and treatments. TEACHING, RESEARCH AND CLINICAL EXPERTISE Patrick J. Healey, MD, is chief of the Division of Transplant Surgery at Seattle Children’s Hospital. He received his MD from the Boston University School of Medicine. He completed his general surgery residency at the Hartford Hospital. He completed fellowship training in abdominal transplantation and pediatric surgery at the University of Washington and Seattle Children’s, respectively. Dr. Healey has expertise and training in pediatric transplantation, specifically of the liver and kidney. His clinical and research interests include transplantation in infants and small children, neonatal surgery, congenital anomalies and pediatric tumors. 220 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Simon P. Horslen, MBChB, is medical director of Liver and Intestinal Transplantation at Seattle Children’s Hospital and professor of pediatrics at the University of Washington School of Medicine. He is helping lead the expansion of the Children’s transplant program. Dr. Horslen earned his medical degree from the University of Bristol, England. He is a founding fellow of the Royal College of Pediatric and Child Health and a member of the Royal College of Physicians and is accredited in general pediatrics and pediatric gastroenterology. He was medical director of the pediatric transplant program at the University of Nebraska Medical Center. Clinical and research interests include metabolic liver disease, intestinal failure and liver and intestine transplantation. Dr. Horslen is a local Principal Investigator for the multicenter Studies in Pediatric Liver Transplantation (SPLIT). He serves as co-chair of the Education Committee and member of the Nominations Committee for the International Transplant Surgery Pediatric Transplant Society. He is chairman of the United Network of Organ Sharing (UNOS) Pediatric Liver Transplant Subcommittee and member of other UNOS committees. He is also active in other organizations, and he gives resident lectures and organizes symposiums and courses. Ruth A. McDonald, MD, is medical director of solid organ transplantation at Seattle Children’s Hospital and associate professor of pediatrics at the University of Washington School of Medicine. She also serves as co-director of several outreach clinics in pediatric nephrology in Washington, Alaska and Montana. She earned her MD at the University of Minnesota. She completed her residency and served as assistant chief resident, and completed a fellowship in the Division of Pediatric Nephrology at the University of Washington. She serves as principal investigator in many multicenter research studies on pediatric renal transplantation. She has a special clinical interest in post-transplant lymphoproliferative disorder and viral infections after transplant in all solid organ transplant recipients. She is an at-large member of the Children’s University Medical Group Board of Directors and chairs the group’s Clinical Practice Committee. Dr. McDonald is well known and respected nationally as a leader in national organ allocation policy development, working actively in several organizations. She serves on the United Network for Organ Sharing (UNOS) Pediatric Committee and has been chair and vice chair; she is a member of other UNOS committees and serves on the board of directors. Karen F. Murray, MD, is director of the hepatobiliary program at Seattle Children’s Hospital and program director of gastroenterology education; she is associate professor in the Department of Pediatrics at FACULTY Patrick J. Healey, MD, Chief Simon P. Horslen, MBChB Ruth A. McDonald, MD Karen F. Murray, MD Jorge D. Reyes, MD, Director of Transplant Services Patrick J. Healey MD, Chief the University of Washington School of Medicine. She received her MD from Johns Hopkins School of Medicine and did a pediatrics residency and a chief resident year at Seattle Children’s. She completed a clinical and research fellowship in gastroenterology and nutrition in the combined program at Children’s Hospital Boston and Massachusetts General Hospital, Harvard Medical School. Dr. Murray has done research and work in Bangladesh and Tanzania. In addition to clinical care in gastroenterology and transplantation, she has an active clinical research program in hepatology. Her main focus is in the treatment and pathophysiology of hepatitis C viral infection, and her studies include the treatment of hepatitis B viral infection and nonalcoholic fatty liver disease. Dr. Murray is president-elect of Seattle Children’s medical staff. She is a member of the Gastroenterology Sub-board of the American Board of Pediatrics, and is on the steering committees of three National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) clinical research networks related to her research. She mentors pediatrics residents and speaks at Seattle Children’s noon conferences. Jorge D. Reyes, MD, is director of Transplant Services at Seattle Children’s Hospital and chief of the Division of Transplantation in the Department of Surgery at the University of Washington. He received his MD and completed some of his residency in Brazil. He also held various surgical residencies, research positions and fellowships in New York, Boston and at the University of Pittsburgh. Dr. Reyes is internationally known for his research from the University of Pittsburgh. He established the intestine program there, along with some of the techniques involved in the procedure. He also established the university’s living liver donor transplant program and its protocol. He is working to bring both programs to the University of Washington. He serves as a board member for LifeCenter Northwest along with several committees for the United Network for Organ Sharing (UNOS). RESEARCH FUNDING New Simon P. Horslen Studies of Pediatric Liver Transplantation, EMMES Corporation, National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS, $56,723 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 221 Transplant Surgery TEACHING AND PRESENTATIONS Simon P. Horslen Intestinal Transplantation, gastroenterology Grand Rounds, University of Washington, January 21, 2005 Liver and Intestinal Transplant Outreach, Spokane, Wash., March 2, 2005 Liver and Intestinal Transplant Outreach, Mary Bridge Children’s Hospital, Tacoma, Wash., April 14, 2005 Liver and Intestinal Transplant Outreach, Anchorage, Alaska, May 26–27, 2005 Isolated Liver Transplantation in Short Gut Patients — Missed Opportunities?, Ninth International Small Bowel Transplantation Symposium, Brussels, Belgium, July 2, 2005 Liver and Intestinal Transplantation Outreach, Boise, Idaho, July 26, 2005 Growth, Puberty and Cognitive Development and Post-Graduate Course: Fundamentals of Pediatric Transplantation (course organizer), Third Congress of the International Pediatric Transplant Association, Innsbruck, Austria, August 2005 Neonatal Liver Disease, 75th North Pacific Pediatric Society meeting, Blaine, Wash., August 28, 2005 Neonatal Liver Disease, Spokane Pediatric Society, Sacred Heart Hospital, Spokane, Wash., October 11, 2005 Liver and Intestine Transplantation in Children, Pediatric Grand Rounds, Sacred Heart Hospital, Spokane, Wash., October 12, 2005 Liver Disease in Adolescence (chair and course organizer), AASLD/NASPGHAN Pediatric Symposium, AASLD annual meeting, San Francisco, November 2005 222 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Ruth A. McDonald, MD Renal Allograft Allocation in Children, KARS meeting, Chicago, January 13, 2005 Update on the Transplant Registry, 2004, NAPRTCS annual meeting, Las Vegas, January 14, 2005 Management of the Sensitized Transplant Recipient, Dialysis Annual Conference, Tampa, Fla., March 2, 2005 Chronic Renal Insufficiency and Failure, Genentech Training Seminar, San Francisco, March 4, 2005 Extended Donor Criteria and the Pediatric Recipient: How to Optimize the Deceased Donor List for the Benefit of Our Patients, American Society of Pediatric Nephrology annual meeting, Washington, D.C., May 16, 2005 Optimizing Living Donor Transplantation in Children, American Transplant Congress, Pediatric Symposium, May 21, 2005 Update: NAPRTCS Transplant Registry, Third Congress of IPTA, Innsbruck, Austria, August 7, 2005 Karen F. Murray Common GI Problems, guest faculty lecture, noon conference, University of Washington, April 12, 2005 Neonatal Cholestasis, lecture to nutritionists in the region, ROSS, May 10, 2005 Pediatric Gastroenterology: Common Problems and Hepatitis C Infection, plenary speaker, 33rd Annual Advances in Family Practice and Primary Care, Seattle, 2005 Cholestasis, guest faculty lecture, noon conference, University of Washington, 2005 Visiting professor: Pocatello and Boise, Idaho, 2005 Transplant Surgery Jorge D. Reyes, MD Transfer of Care to the Community: Where Are the Gaps? and Enhancing Wellness: Lifelong Success for the Transplant Patient, panel discussion, Winter AST, Banff, Alberta, Canada, March 16–20, 2005 Intestinal Transplantation: Historical Notes, Principles and Controversies, Grand Rounds, University of Southern California, Los Angeles, April 16, 2005 Intestinal Transplantation: Historical Notes, Principles and Controversies, Grand Rounds, University of Chicago, June 8, 2005 Surgical Strategies to Maximize Organ Utilization in Intestinal Transplantation, IX International Small Bowel Transplantation Symposium, Brussels, Belgium, June 30–July 2, 2005 Transplanting Children with Hepatocellular Carcinoma — How Do They Differ from Adults, International Liver Transplantation Society 11th Annual International Congress, Los Angeles, July 20–23, 2005 Steroid Avoidance in Intestinal Transplantation, International Pediatric Transplantation Association 3rd World Congress on Pediatric Transplantation, Innsbruck, Austria, August 6–9, 2005 Addressing the Medical Care of Live Lung, Liver, Intestinal and Pancreas Donors, Vancouver Forum for World Transplant Congress, Vancouver, BC, Canada, September 14–16, 2005 Intestinal Transplantation: Historical Notes, Principles and Controversies, Grand Rounds, BarnesJewish Hospital, St. Louis, Mo., October 3, 2005 A Brain, a Heart, and Courage: Evolving Paradigms of Clinical Tolerance Induction, International Transplant Nursing Society, Seattle, November 1, 2005 PUBLICATIONS Ake JA, Jelacic S, Ciol MA, Watkins SL, Murray KF, Christie DL, Tarr PI. The nephroprotective effect of intravenous volume expansion during Eschericia coli 0157:H7 infection. Pediatr. 2005;115(6):673–680. Benfeild MR, Tejani A, Harmon WE, McDonald RA, Stablein DM, McIntosh M, Rose S, CCTPT study group. A randomized multicenter trial of OKT3 mAbs induction compared with intravenous cyclosporine in pediatric renal transplantation. Pediatr Transplant. 2005;9:282–292. Bousvaros A, Guandalini S, Baldassano R, Botelho C, Evans J, Ferry G, Goldin B, Hartigan L, Kugathasan S, Levy J, Murray KF, Oliva-Hemker M, Rosh J, Tolia V, Young R, Zholudev A, Vanderhoof J, Hibberd PL. A randomized, double-blind trial of Lactobacillus GG vs. placebo in addition to standard maintenance therapy for children with Crohn disease. Inflamm Bowel Dis. 2005;11(9):833–839. Bousvaros A, Murray KF, Leichtner A. Chapra, LaMont and Bonis, eds. Clinical manifestation and diagnosis of Crohn disease in children and adolescents. Up to Date. Wellesly, 2005. Casale P, Grady RW, Mitchell ME, Healey PJ. Recurrent urinary tract infection in the post-transplant reflux nephropathy patient: is reflux in the native ureter the culprit? J Pediatr Transplant. June 2005;9(3):324–327. Flynn B, Park BK, Bond G, McGhee W, Mazariegos G, Sindhi R, Reyes JD, Abu-Elmaged K. Immunosuppressive strategies for intestinal transplantation: a review of a tolerogenic regimen. Progress in Transplantation. 2005;15(1). Gonzalez-Peralta RP, Kelly DA, Haber B, Molleston J, Murray KF, Jonas MM, Shelton M, Mieli-Vergani G, Lurie Y, Martin S, Lang T, Baczkowski A, Geffner M, Gupta S, Laughlin M, International Pediatric Hepatitis C Therapy Group. Interferon alfa-2b in combination with ribavirin for the treatment of chronic hepatitis C in children: efficacy, safety, and pharmacokinetics. Hepatol. 2005;42(5):1010–1018. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 223 Transplant Surgery Grant D, Abu-Elmaged K, Reyes JD, Tzakis A, Langnas A, Fishbein T, Goulet O, Farmer D. 2003 report of the intestine transplant registry: a new era has dawned. Ann Surg. 2005;241(4). Macedo C, Shindhi R, Mazariegos GV, Abu-Elmagd K, Bond GJ, Reyes JD. Sclerosing peritonitis after intestinal transplantation in children. Pediatr Transplant. 2005;9:187–191. Gross TG, Bucuvalas JC, Park JR, Greiner TC, Hinrich SH, Kaufman SS, Langnas AN, McDonald RA, Ryckman FC, Shaw BW, Sudan DL, Lynch JC. Low-dose chemotherapy for Epstein-Barr virus-positive post-transplantation lymphoproliferative disease in children after solid organ transplantation. J Clin Oncol. Sep 20, 2005;23(27):6481–6488. Murray KF, Carithers RL. AASLD practice guidelines: Evaluation of the patient for liver transplantation. Hepatol. 2005;41(6):1407–1432. Harmon WE, McDonald RA, Reyes JD, Bridges ND, Sweet SC, Sommers CM, Guidinger MK. Pediatric transplantation. Am J Transplant. April 2005; 5(4 Pt 2):887–903. Kim SS, Lau ST, Lee SL, Schaller R Jr, Healey PJ, Ledbetter DJ, Sawin RS, Waldhausen JH. Pyloromyotomy: a comparison of laparoscopic, circumumbilical, and right upper quadrant operative techniques. J Am Coll Surg. July 2005;201(1):66–70. Lau ST, Kim SS, Ledbetter DJ, Healey PJ. Fraternal twins with Morgagni hernias: a case report. J Pediatr Surg. April 2005;40(4):725–727. Macedo C, Donnenberg A, Popescu I, Reyes JD, AbuEmagd K, Shapiro R, Zeevi A, Fung JJ, Storkus WJ, Metes D. EBV-specific memory CD8(+) T cell phenotype and function in stable solid organ transplant patients. Transpl Immunol. Jun 2005;14(2):109–116. Macedo C, Popescu I, Abu-Emagd K, Reyes JD, Shapiro R, Zeevi A, Berghaus JM, Wang LF, Lu L, Thomson A, Storkus W, Fung J, Metes D. Augmentation of type-1 polarizing ability of monocyte-derived dendritic cells from chronically immunosuppressed organ-transplant recipients. Transplant. February 27, 2005;79(4):451–459. 224 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Murray KF, Finn LS, Taylor SL, Seidel KD, Larson AM. A comparison of liver histology and alanine amino transferase levels in children and adults with chronic hepatitis C. J Pediatr Gastroenterol Nutr. 2005;41(5):634–638. Reyes JD. Introduction to selected reports from the Sixth Annual American Transplant Congress. The Immunology Report 2005; 2(1):3–4. Reyes JD, Mazariegos GV, Abu-Elmagd K, Macedo C, Bond GJ, Murase N, Peters J, Sindhi R, Starzl TE. Intestinal transplantation under tacrolimus monotherapy after perioperative lymphoid depletion with rabbit anti-thymocyte globulin (ThymoglobulinВ®). Am J Transplant. February 24, 2005;5:1–7. Smith JM, McDonald RA. Renal transplantation in adolescents In: Adolescent medicine clinics: nephrologic disorders in the adolescent. Sherwinter J, Foulds DM, Greydanus DE, eds. Philadelphia: Elsevier Sanders, 2005;(16):201–214. Sudan D, Dibaise J, Torres C, Thompson J, Raynor S, Gilroy R, Horslen SP, Grant W, Botha J, Langnas A. A multidisciplinary approach to the treatment of intestinal failure. J Gastrointest Surg. Feb 2005; 9(2):165–177. Urology The clinical branch of the Division of Urology (in the Department of Surgery) manages all pediatric health care problems relating to the urogenital system. The division’s medical and surgical treatments take into consideration the growth and developmental needs of young children. We are the world leader in the treatment of complex urologic malformations — including exstrophy/epispadias, cloaca, neurogenic bladder dysfunction, patients with posterior urethral valves and hydronephrosis — and we also treat routine and common abnormalities and problems such as urinary tract infection, meatal stenosis and hypospadias. We use laboratory research and clinical observation to solve problems in children with urinary malformation and malfunction. The division has a very active basic research laboratory that is investigating the growth and development of the lining of the urinary tract, the uroepithelium. Research also includes clinical studies and trials relating to complex and routine urologic conditions in children. Our pediatric urologists are supported by registered nurses and nurse practitioners who specialize in the care of children with bladder and voiding dysfunction. We offer bladder retraining and biofeedback for voiding abnormalities and detailed urologic functional assessment using urodynamics. TEACHING, RESEARCH AND CLINICAL EXPERTISE Michael E. Mitchell, MD, was chief of the Division of Urology at Seattle Children’s Hospital and professor of urology at the University of Washington School of Medicine until mid-2006 when he retired from Seattle Children’s. He held the Guild Association Endowed Chair in Pediatric Urology, which was renamed in his honor to the Dr. Michael Mitchell Endowed Chair in Pediatric Urology. He has held leadership positions in the Society for Pediatric Urology, American Academy of Pediatrics and American Board of Urology. He was instrumental in the development of the Inservice Examination for Pediatric Urology and edited a major urology textbook. He is widely published and is con- FACULTY Michael E. Mitchell, MD, Chief James A. Bassuk, PhD Richard W. Grady, MD Byron D. Joyner, MD sulting editor for several journals. Dr. Mitchell is world-renowned for contributions in developing the concept of the valve bladder syndrome, the procedure of gastrocystoplasty bladder reconstruction, Mitchell bladder neck repair, the Mitchell technique of bladder reconstruction in patients with bladder exstrophy and new and innovative concepts for the reconstruction of the genitalia such as found in patients with epispadias. He has also developed new concepts and theories relating to the embryology of the urinary tract. His techniques for primary bladder closure in patients with exstrophy complex are now used worldwide. Dr. Mitchell is developing a Center of Excellence for the treatment of bladder exstrophy and patients with complex urinary malformations. He has received the Hugh Hampton Young Award for outstanding contributions to the field of urology. James A. Bassuk, PhD, is director of research in the Division of Urology at Seattle Children’s Hospital and affiliate assistant professor at the University of Washington School of Medicine. Dr. Bassuk achieved his PhD in zoology from Iowa State University. He trained in chemical carcinogenesis at the Institute for Cancer Research at the Fox Chase Cancer Center in Philadelphia, in collagen metabolism at the Michael E. Mitchell MD, Chief SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 225 Urology University of Medicine and Dentistry of New Jersey and in angiogenesis in the Department of Biological Structure at the University of Washington. He has studied developmental programs that lead to a normal, functional urinary bladder. He works in a laboratory at Seattle Children’s Hospital for tissue culture, cell biology and animal studies and a laboratory at the University of Washington for molecular biology and recombinant protein chemistry. Dr. Bassuk also trains and supervises students, technicians, fellows and residents in the design, performance and interpretation of experimental designs. the University of Washington’s Julian S. Ansell Teaching Award for his new approaches to teaching residents about interpersonal and communication skills and professionalism. Dr. Joyner has interests in clinical research related to voiding dysfunction and urinary tract infections in children. He is an active member of many professional societies including the American Urological Association, American Academy of Pediatrics, Society of University Urologists and American College of Surgeons. RESEARCH FUNDING Richard W. Grady, MD, is attending physician at Seattle Children’s Hospital, and fellowship program director and director of clinical research in the Division of Urology. He is associate professor of urology at the University of Washington School of Medicine. Dr. Grady received his MD from the University of Michigan and completed a urology residency at the Cleveland Clinic Foundation. His training includes a research scholarship at the NIH in cell mediated immunity and a fellowship in pediatric urology at Seattle Children’s. Dr. Grady’s research interests include urinary tract infection. He has clinical research interests in studying complex defects such as exstrophy, neurogenic bladder conditions and intersex states. Current projects include the development of a multiplatform relational clinical database, a study of quality of life in patients with spina bifida and several clinical research trials studying methods to treat these conditions. Dr. Grady is active in regional, national and international urologic societies. He has an interest in international medicine and has been a visiting professor internationally in addition to participating in medical missions to India and Mongolia. Byron D. Joyner, MD, is associate professor at the University of Washington School of Medicine. He is program director for the Division of Urology at the university. He received his MD from Harvard Medical School. He completed his residency at Massachusetts General Hospital. He completed a research fellowship at Children’s Hospital Boston and two years of training at the Hospital for Sick Children in Toronto. He served for four years in the U.S. Army as chief of pediatric urology at Madigan Army Medical Center. He is responsible for the education and competency training of urology residents. He trained in the Seattle Children’s Teaching Scholars program and received 226 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON New Richard W. Grady, MD Cranberry as an E.coli Anti-Uroadherence Agent in a Pediatric Population, National Kidney Foundation, $50,000 Continuing James A. Bassuk, PhD Regulation of Urothelial Cell Behavior by SPARC, National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS, $249,180 Proteins as Signals in Urothelial Cell Proliferation, National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS, $260,216 Evaluation of Heterogeneity in Urothelial Cells in Interstitial Cystitis and Clinical Management of the Disease by Recombinant Modulators, University of Washington, National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS, $117,504 PRESENTATIONS AND TEACHING ACTIVITIES James A. Bassuk, PhD Bypass of Replicative Senescence in Human Urothelial Cells; The C-Terminal Ca2+-Binding Domain of SPARC Confers Anti-Spreading Activity to Human Urothelial Cells of a Normal and Ex-Strophic Phenotype; The Nuclear Localization Sequence of SPARC Influences Its Intracellular Localization and Activity in Human Urothelial Cells; Spreading of Embryologically Distinct Urothelial Cells Inhibited by SPARC; and Validation of Methods for Determination of Urothelial Cell Viability in the Laboratory, abstracts Urology presented at the Urothelial Cell Physiology in Normal and Disease States Symposium, satellite meeting of the XXXV International Congress of Physiological Sciences, San Diego, March 29–30, 2005 Urothelial Tug-of-War: Balancing of Adhesive and Counteradhesive Forces, podium abstract presented at the 2005 International Bladder Symposium of the National Bladder Foundation, Baltimore, April 15-16, 2005 Distribution of the FGF-10 Receptor Is Indicative of Targeted Therapy for Turnover of Transitional Epithelium, abstract presented at the 2005 International Bladder Symposium of the National Bladder Foundation, Baltimore, April 15-16, 2005 Podium speaker and participant, National Bladder Foundation International Symposium, Baltimore, April 15-16, 2005 Richard W. Grady, MD The Evolution of the Exstrophy Repair, visiting professorship, Christian Medical College, Vellore, India, February 2005 DEHP and the Developing GU System, Grand Rounds, Seattle Children’s, June 2005 Panel on intersex, Society of Pediatric Urology, AUA national meeting, October 2005 Environmental Toxins and the Developing GU System, Out of Harm’s Way Conference, Spokane, Wash., October 2005 Byron D. Joyner, MD National Survey of Urology Program Director’s Assessment, faculty lecturer, ACGME national meeting, April 2005 Michael E. Mitchell, MD State of the Art: New Concepts in Vesicoureteral Reflux, 52nd James C. Kimbrough Urologic Seminar, Honolulu, January 2005 Why Ectopic Ureteroceles Are Not Ectopic, Pediatric Urology Winter Forum, Whistler, BC, Canada, February 2005 Random Thoughts on Pathologic Development of the Urinary Tract or Why Is an Ectopic Ureterocele Not Ectopic, John Duckett Memorial Lectureship, European Society for Pediatric Urology/American Academy of Pediatrics 2nd Joint Meeting, Uppsala, Sweden, June 2005 Exstrophy, surgical unit nursing in-service, Seattle Children’s, September 2005 The Changing Bladder of Early Childhood, Society for Fetal Urology, Washington, D.C., October 2005 PUBLICATIONS Carr M, Mitchell ME. Neuroblastoma. In: Urologic Oncology. Richie JP, D’Amico AV, eds. Philadelphia: Elsevier Saunders, 2005:737–752. Casale P, Grady RW, Lee RS, Joyner BD, Mitchell ME. Symptomatic refluxing distal ureteral stumps after nephroureterectomy and heminephroureterectomy: what should we do? J Urol. January 2005;173(1):204–206. Casale P, Grady RW, Mitchell M, Healey P. Recurrent urinary tract infection in the post-transplant reflux nephropathy patient: is reflux in the native ureter the culprit? Pediatr Transplant. June 2005;9(3):324–327. Delostrinos CF, Hudson AE, Feng WC, Kosman J, Bassuk JA. The C-terminal extracellular Ca2+binding domain of SPARC confers anti-spreading activity to human urothelial cells. J Cell Physiol. Jan 2006;206(1):211. Franco I, Horowitz M, Grady RW, et al. Efficacy and safety of oxybutynin in children with detrusor hyperreflexia secondary to neurogenic bladder dysfunction. J Urol. Jan 2005;173:221–225. Grady RW. Systemic quinolone antibiotics in children: a review of the use and safety. Expert Opin Drug Saf. 2005 Jul;4(4):623-630. Hudson AE, Feng WC, Delostrinos CF, Carmean N, Bassuk JA. Spreading of embryologically distinct urothelial cells is inhibited by SPARC. J Cell Physiol. Feb 2005;202(2):453–463. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 227 Urology Joyner BD, Mitchell ME. Ureteropelvic junction obstruction. In: Pediatric Surgery, 6th ed. Grosfield JL, O’Neill JA, Forkalsrud CW, Coran AG, eds. Elsevier Publishers, 2005. Joyner BD, Seidel K, Stoll D, Mitchell ME. Report of the National Survey of Urology Program Directors: attitudes and actions regarding the ACGME regulations. J Urol. October 2005; publication pending. Mitchell ME, Black PC, Grady RW. Epispadias repair: complete penile disassembly. In: Advanced Urologic Surgery, 3rd ed. Hohenfellner R, Fitzpatrick JM, McAninch JW, eds. Blackwell Publishing, Ltd., 2005:194–198. Porter M, Faizan K, Grady R, Mueller B. Hypospadias in Washington state: maternal risk factors and prevalence trends. Pediatr. Mar 2005; e-publication. Walsh T, Joyner BD. Evaluation of the pediatric patient with a non-traumatic acute scrotum. AUA Update Series, March 2005. Zhang D, Kosman J, Carmean N, Grady R, Bassuk JA. FGF-10 and its receptor exhibit bi-directional paracrine targeting to urothelial and smooth muscle cells in the lower urinary tract. Am J Physiol – Renal Physiol. 2006: (in press). 228 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Transplant Center The Children’s Transplant Center offers comprehensive evaluation and care to patients with end-stage diseases of the heart, liver, kidneys and intestines. We are committed to providing optimal growth and quality of life for all of our patients — and helping families return to normal, active lives. The Transplant Center is a leader in pediatric liver, heart and kidney transplant and viral surveillance, and our graft and survival outcomes are consistently among the best in the nation. Our liver transplant program is at the forefront of improving surgical techniques for split-liver and living donor liver transplants. Our heart transplant program serves some of the highest volumes of patients in the country; its innovative clinical program can handle complex neonate and infant transplants. Children’s is one of the top five kidney transplant centers in the United States and is actively involved in multicenter studies to reduce patients’ dependence on immunosuppressive drugs. Our pediatric nephrology fellowship program is one of only six in the country funded by the National Institutes of Health. The center’s intestinal care program, established in 2005, brings together Drs. Simon Horslen and Jorge Reyes, who have more combined experience treating children with intestinal failure than any other physician pair in the nation. Our physician leadership is also actively involved in shaping national organ donation policy through the United Network for Organ Sharing (UNOS). FACULTY Robert J. Boucek Jr., MD, Chief of the Division of Cardiology (see also, Department of Pediatrics, Division of Cardiology) Gordon A. Cohen, MD, PhD, Chief of the Division of Cardiothoracic Surgery (see also, Department of Surgery, Division of Cardiothoracic Surgery) Patrick J. Healey, MD, Chief of the Division of Transplant Surgery (see also, Department of Surgery, Division of Transplant Surgery) Simon P. Horslen, MBChB, Medical Director for Liver and Intestinal Transplantation (see also, Department of Pediatrics, Division of Gastroenterology and Department of Surgery, Division of Transplant Surgery) Ruth A. McDonald, MD, Medical Director for Solid Organ Transplant (see also, Department of Pediatrics, Division of Nephrology and Department of Surgery, Division of Transplant Surgery) Karen F. Murray, MD, Director of the Hepatobiliary Program (see also, Department of Pediatrics, Division of Gastroenterology and Department of Surgery, Division of Transplant Surgery) Jodi M. Smith, MD (see also, Department of Pediatrics, Division of Nephrology) John H.T. Waldhausen, MD, Director of Pediatric Surgery Fellowships and Surgery Education (see also, Department of Surgery, Division of General and Thoracic Surgery) Delphine Yung, MD (see also, Department of Pediatrics, Division of Cardiology) Jorge D. Reyes, MD, Director of Transplant Services (see also, Department of Surgery, Division of Transplant Surgery) Robert S. Sawin, MD, Surgeonin-Chief (see also, Department of Surgery, Division of General and Thoracic Surgery) SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 229 Research 230 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Incredible growth, remarkable results and a commitment to the highest ethical standards are the hallmarks of Seattle Children’s Hospital research program. Funding for more than 400 pioneering projects continues to expand rapidly. In 2005, our research program received nearly $26 million in funding from private foundations, corporations and the government, a 20 percent increase over 2004. In late 2005, we announced our intention to add up to 1 million James Hendricks, PhD Vice President, Research square feet of additional research space during the next 10 to 20 years. There has never been a more exciting time for research at Seattle Children’s. Our commitment to research ensures that the families we serve have access to state-of-the-art treatments and diagnostic tools. This report highlights some of the innovative projects and physician-scientists whose work is influencing the practice of pediatric medicine and advancing the basic knowledge of the molecular underpinnings of disease. More successes lie ahead as we work to develop new treatments and therapies that will change the lives of children and families for the better. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 231 Research Research is thriving at Seattle Children’s. The breadth and vitality of our research enterprise is a product of our world-class faculty. These dedicated physician-scientists are advancing the frontiers of knowledge and making discoveries aimed at preventing, treating and eliminating childhood disease. We operate 110,000 square feet of research space at three locations. Children’s Westlake facility and the hospital’s main campus host 65,000 square feet of wet laboratory space. The main campus also has a 5,000-square-foot Pediatric Clinical Research Center and Investigational Pharmacy Service. Clinical and outcomes research are housed in 40,000 square feet at our facility in Seattle’s Metropolitan Park West building. We also support pediatric research on the University of Washington and Fred Hutchinson Cancer Research Center campuses. Though research is under way in every medical specialty and scientific discipline at Seattle Children’s, several areas of strength and achievement stand out in our program. This section highlights some of the research contributions from our programs in bioethics, immunology, infectious disease, tissue response to injury, clinical trials development, cancer and health services research. Establishing Seattle Children’s Pediatric Bioethics Center In late 2004, Seattle Children’s established the nation’s п¬Ѓrst center devoted exclusively to the study and debate of ethical issues in health-care delivery and medical research that affect children. The mission of the Treuman Katz Center for Pediatric Bioethics is to educate health-care professionals, caregivers, parents and scientists — and to provide an unbiased forum where controversies in the п¬Ѓeld can be openly debated. In keeping with this mission, the bioethics center accepts no support from industry. In July 2005, the center hosted a п¬Ѓrst-of-its-kind event — a conference to debate the controversial issues that 232 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON arise when children participate in biomedical research. The conference drew more than 200 attendees from the United States, Canada, South America and Africa. In additional to hosting an annual conference, the bioethics center promotes scholarship on ethical quandaries, trains the next generation of pediatricians and ethicists about pediatric bioethics, and provides consultation to families, health-care providers, researchers and policymakers about pediatric bioethics. The center’s goal is to improve pediatric bioethics practices and policies on a national and international level. The center is named for retired president and CEO Treuman Katz, who actively shared in the vision for the center’s creation. Research Immunology Seattle Children’s is the referral center for children and adults with immune problems throughout Washington, Alaska, Montana and Idaho. We have genetic testing and diagnostic capabilities that no one else in our region has. We also serve as an international center for prenatal and neonatal testing, and for testing of adults to identify carriers of immune deп¬Ѓciency disorders. Our faculty and their laboratory teams are internationally recognized for their expertise and leadership in basic, clinical and translational research related to primary immunodeп¬Ѓciency diseases (PIDD). PIDD refers to more than 130 different genetic defects involving the immune system. As many as 500,000 Americans and 10 million people worldwide are affected by PIDD, and unable to п¬Ѓght off bacteria, viruses, parasites, fungi and malignant cells. This can lead to frequent infections that are difп¬Ѓcult to п¬Ѓght and to an increased incidence of cancer. Because each of these diseases is caused by a defect in a single gene, they are a fertile ground for researching genetic conditions. Several research teams at Seattle Children’s are working on therapeutic approaches to mend the defective genes, including gene therapy and gene repair. By the early 1990s, Children’s researchers were making the connection between immune deп¬Ѓciencies and genes. This opened new possibilities for treatment. Recent work at Children’s and elsewhere, coupled with improved methods for gene sequencing, has made it quicker and easier to identify the genetic basis of many previously unknown immune disorders. Infectious Disease and Host-Pathogen Interaction Childhood infections are a major cause of morbidity and mortality in the United States and around the world. The funding emphasis on preventing infections by many national and international organizations underscores the global impact these diseases have on the health of children. Respiratory illnesses, central nervous system infection and AIDS are just a few of the infections that have a signiп¬Ѓcant impact on pediatric health and remain a priority. Seattle Children’s has been at the forefront of bench and clinical investigations of pediatric infection for the past 25 years. Major areas of interest continue to focus on bacteria that cause respiratory, brain and bloodstream infection in newborns, infants and young children. This research investigates the speciп¬Ѓc traits of microbes that influence their ability to establish infection in a human host. It also studies the immune mechanisms that thwart infection by these pathogens. This work includes basic science exploration at the molecular and cellular level, and the use of animal models of human infections. The goal is to deп¬Ѓne mechanisms Carol H. Miao, PhD: Can gene therapy answer the question of hemophilia? Dr. Carol Miao is developing non-viral gene therapy protocols for the treatment of hemophilia. Gene therapy holds the promise of helping hemophilia patients begin producing sufficient clotting factor, thus removing or at least lessening their dependence on weekly infusions. With this advance, it may be possible for people born with severe hemophilia to reduce or eliminate their symptoms over time. Miao and her colleagues are the first to use non-viral naked DNA delivery to achieve therapeutic levels of factor VIII and factor IX gene expression in hemophilia A and hemophilia B mouse models, respectively. Since gene therapy research trials with humans have had mixed results, the future for gene therapy in hemophilia is continuing at a moderate pace. However, many projects are continuing in animal models. Improved long-term expression of the new genes will require the development of better ways to deliver the new genes into the cells. Miao and her team are investigating safer and more efficient non-viral vectors and delivery methods suitable for clinical applications. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 233 Research of virulence or host responses that influence how disease develops and how much it injures tissue. This research is advancing the understanding of the biological basis of infections that occur in healthy children as well as those with cancer or genetic, developmental or immune deп¬Ѓciencies. The results may ultimately lead to improved diagnoses and new approaches to disease management. They should also identify targets for new antimicrobial therapy and vaccines. Researchers at Seattle Children’s have capitalized on these observations to promote the development of new antibiotic treatments (such as TOBIв„ў), to understand how bacteria develop resistance to antibiotics, and to identify new vaccine candidates for disease prevention. Our HIV/AIDS program has evolved rapidly during the past 15 years to become one of the sentinel programs in the country. Our research continues to contribute signiп¬Ѓcantly to understanding how the HIV virus develops resistance to antiviral drugs. Collaborations with investigators and similar programs at the University of Washington and Fred Hutchinson Cancer Research Center continue to enhance and strengthen Children’sbased investigations. Because of our strength in this п¬Ѓeld we have developed one of the best training programs for pediatric physicianscientists and non-physician scientists in host-pathogen interaction. Fully 60% to 70% of our trainees establish careers that include research speciп¬Ѓc to pediatric infections. Seattle Children’s has successfully maintained an NIH-funded training program for 22 years. This type of program is critical to the success of developing our future pediatric programs and to improving pediatric health care. Tissue Response to Injury The body’s response to injury, whether due to illness, trauma or other insults, can either help or hinder the healing process. Understanding the body’s response to injury at the cellular, tissue and whole organ level is essential to the development of therapeutic interventions that will promote meaningful survival without disability. Researchers at Seattle Children’s investigate this repair process using basic science tools at the molecular, cellular and animal model level. The overall goal is to develop new clinical tools to help providers manage, treat and eventually cure acute and chronic diseases of childhood. Researchers from several disciplines are investigating how tissue in solid organs responds to injury. Our nephrology research program Hans D. Ochs, MD: Correcting gene mutations in congenital disorders Dr. Hans Ochs is conducting in vitro studies that may lead to gene therapy for congenital disorders caused by mutations of genes that are involved in development of the immune system and immune responses. These studies may provide information necessary to begin human gene replacement therapy for immunedeficiency disorders, which can cause multiple disabilities. For example, adenosine deaminase (ADA) deficiency and nucleoside phosphorylase (NP) deficiency are associated with neurological syndromes, liver disease and bone abnormalities. Presentations of Wiskott-Aldrich syndrome include a platelet defect, eczema, autoimmune disorders and a high incidence of malignancies. Ochs has generated databases to cover mutations in WASP, Btk, CD40 ligand, SAP, and other genes causing immune deficiencies. Most recently, his laboratory has focused on two newly discovered genes causing autosomal recessive hyper-IgM syndrome (activationinduced cytidine deaminase, AID), uracil-DNA glycosylate (UNG), and the scurfy gene, FOXP3, responsible for a syndrome involving immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX). 234 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Research is investigating pathogenetic mechanisms of progressive kidney disease, a process whereby normal renal tissue is destroyed by п¬Ѓbrosis in response to injury. These studies have shown that many of the pathogenetic pathways that destroy renal tissue are similar to the way other solid organs are destroyed by п¬Ѓbrosis — especially the lungs, liver and heart. Our urology program is investigating mechanisms of bladder regeneration following injury. The goal is to develop new tissue engineering strategies to reconstruct a chronically injured hollow organ, such as the urinary bladder. The ability to regenerate or rebuild tissue that has been damaged by chronic injury is relevant to most organ systems. These studies intersect with the disciplines of vascular and matrix biology and bioengineering, all disciplines that have world-renowned experts working at the University of Washington. Tissue injury triggered by hypoxia and ischemia is a common cause of damage. Some organs such as the liver and kidneys display a remarkable ability to recover following time-limited hypoxia, while for other organs, such as the brain and heart, even shortlived ischemia may have permanent and even fatal consequences. Our cardiology program is investigating metabolic pathways of cardioprotection and mechanisms of myocardial regeneration and repair. Our neonatology colleagues, based at the University of Washington, are investigating mechanisms of neuroprotection in infants exposed to brain ischemia. This group also has an emerging interest in acute lung injury in collaboration with the newly established Lung Biology Center at the University of Washington. Developing and Leading Clinical Trials For several decades, one of Seattle Children’s greatest research strengths has been developing and conducting clinical trials involving new therapies for children with a variety of chronic disorders. The successful clinical trial networks established by our faculty have brought international recognition to the hospital. We have had an international impact in the following areas: Pediatric Oncology Dr. John Hartman helped found the Children’s Cancer Group in the 1960s. This group, which evolved into Children’s Oncology Group (COG), changed the course of childhood cancers, such as Wilm tumor, neuroblastoma and acute lymphoblastic leukemia. Seattle Children’s oncologists have always played a lead role in developing and leading clinical trials through COG. The combined efforts of oncology, neurosurgery and pathology have made Seattle Children’s a leader in the Pediatric Brain Tumor Consortium. With the establishment of the Seattle Cancer Care Alliance (SCCA), we also became a premier center for bone marrow transplant and transplant research. Cystic Fibrosis Our research and clinical advances in the treatment of cystic fibrosis (CF) are another example of our leadership. After developing TOBIв„ў, the inhaled antibiotic that revolutionized the treatment of CF lung infections, Seattle Children’s gained a preeminent position in coordinating clinical research for CF. We are the international center for CF therapeutic trials. The Data Coordinating Center for the national CF Therapeutics Development Network is located at Seattle Children’s. Clinical Network Trials The development of new therapeutic agents for children spans a wide range of clinical specialties at this institution. Our nephrology division boasts several nationally recognized faculty who lead clinical trial networks related to renal transplant and chronic renal disorders. Faculty in rheumatology, endocrinology, critical care medicine and cardiology have been leaders in establishing national clinical trial networks, and remain active in developing and participating in these therapeutic trials. Our child psychiatry group is extremely active in clinical trials involving a variety of therapeutic agents to treat childhood depression, psychosis and anxiety. The creation of the Pediatric General Clinical Research Center, funded by the National Center for Research Resources (NCRR) in 1996, provided infrastructure to enhance our involvement in early therapeutic trials (Phase 1 and 2) and has brought together many of Children’s clinical research activities. The growth of the Pediatric General Clinical Research Center has resulted in the center receiving an outstanding ranking by the NCRR at the time of the competitive renewal in 2003. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 235 Research Bonnie W. Ramsey, MD: Changing lives through research Dr. Bonnie Ramsey remembers the moment she decided to devote her energy to changing the odds in the fight against cystic fibrosis (CF). “Two of my patients died within a week of each other and I knew I couldn’t continue to hold the hands of these young boys and girls without personally trying to affect this disease,” she recalls. Ramsey played a vital role in the Children’s research that developed a breakthrough cystic fibrosis treatment: TOBIв„ў, an inhalable form of an existing antibiotic that delivers medicine directly to the lungs where it is needed most, while limiting unnecessary exposure to others parts of the body. She continues to be very involved in clinical research that develops new treatments to improve and extend the lives of children with CF. Her dedication and spirit of inquiry have led to remarkable advances in the treatment of people with CF, helping double their lifespan and vastly improving their quality of life. 236 Childhood Cancer Outcomes–Health Services The overall aim of Seattle Children’s pediatric oncology program is to improve outcomes for children with malignancy. Since its inception, basic research in this program has focused on the developmental aspects of the formation of blood cells with the speciп¬Ѓc goal of developing novel therapeutic modalities. We have identiп¬Ѓed maturationlinked cell surface antigens, and have used this information to develop methods for targeted therapy for malignancies of the blood, and for isolating and characterizing normal and malignant human blood-forming cells. These studies have led to the development of stem cell transplant using isolated CD34+ cells, successful targeted radiotherapy of leukemia and lymphoma, and the development of an innovative approach for treating acute myelogenous leukemia using an antibody-drug conjugate. Research in clinical oncology includes hematopoietic cell therapies that have led to vast improvements in treating a number of pediatric malignancies. Our strong presence in the Children’s Oncology Group has enabled us to introduce pilot studies and lead multisite trials. Current studies are evaluating new approaches for expanding and genetically altering blood-forming cells for therapeutic purposes. A new program is studying the formation of nerves, with a focus on identifying therapeutic targets in tumors of the developing brain. The strength of existing outcomes/health services research by Children’s-afп¬Ѓliated investigators is both methodological and content speciп¬Ѓc. A well-networked, interdisciplinary group of investigators focused on pediatric outcomes has developed here during the last few years. This group represents strengths from a variety of areas at Seattle Children’s, the University of Washington School of Medicine and School of Public Health, the Child Health Institute (CHI), Fred Hutchinson Cancer Research Center and Group Health Cooperative’s Center for Health Studies. This network uses a wealth of research designs, including randomized controlled trials, to test new ways to change patient, family and provider behavior. These intervention trials are placed in a wide variety of community settings, such as schools, child care programs, physician practices and larger health systems. For example, the Puget Sound Pediatric Research Network is a valuable collaboration between community-based physicians and academic researchers that investigates common pediatric conditions. Though the populations studied vary, there is a special focus on the most vulnerable children, including those with special health-care needs and chronic conditions and immigrant, refugee and non–English speaking children and families. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Research Children’s investigators are pushing the envelope, using information technology and the World Wide Web to improve health outcomes by changing behavior. Using existing databases — including Medicaid and commercial health insurance plans, hospital discharge data and Pediatric Health Information Systems data — this group has been able to address important questions in pediatric health care. Their work has been used to change public policy for children and to help Seattle Children’s achieve its mission by improving the quality of care delivered. This network of Children’safп¬Ѓliated investigators has applied their investigational skills to the leading health issues facing children in the United States today, such as behavioral and mental health, injuries, chronic illness, care of pediatric acute illness, and health promotion and disease prevention. Elizabeth A. McCauley, PhD: Recognizing Childhood Anxiety and Depression About 20 years ago, Elizabeth McCauley, PhD, had a career-altering experience. A young teenager came to the emergency room with classic signs of depression. McCauley and her colleagues were perplexed. In the early 1980s, it was still thought that children weren’t able, cognitively or emotionally, to be depressed. Having her personal observation butt up against common knowledge inspired a career-long exploration of childhood anxiety and depression — and McCauley’s research has helped to establish the study of adolescent depression as a discipline and to change how depression in children is understood and treated. A few years ago, she teamed with colleague Ann Vander Stoep, PhD, a University of Washington child psychiatric epidemiologist, to better understand the factors that influence emotional distress in children. Their goal was preventing such distress from progressing to more severe emotional health and behavioral problems. Partnering with the Seattle Public Schools, McCauley and Vander Stoep developed the Developmental Pathways Research Program. Under this umbrella, they are conducting a series of studies that screen middle school students for signs of emotional distress and provide early interventions that address the issues causing the distress. “Initially, we were concerned that we’d uncover a vast need for mental health services that we wouldn’t have the clinical resources to handle. What we found is that most of the children have specific, practical needs, such as homework support or a sense of connectedness. Many of the schools have the resources to meet these needs right in their buildings.” McCauley and Vander Stoep are assessing the effectiveness of a skills-based intervention designed to help eighth-graders make a successful transition to high school, and designing two follow-up studies to evaluate their mental health screening program. The first follow-up study will look at whether the suggested interventions were acted on by the child and family, and if not, why not. The second will assess whether the suggested interventions helped when they were acted upon. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 237 Fellows and Residents 2005-2006 Seattle Children’s Hospital Fellows Adolescent Medicine Megan A. Moreno, MD Anesthesiology James C. Borowiec, MD Bruce Jones, MD Martha Pankovich, MD Ben Pieters, MD Thomas Satterfield, MD Critical Care Medicine J. Elaine Albert, MD Iain R. Asplin, MD Teodor Butiu, MD Angela S. Czaja, MD Mary King, MD Mithya Lewis-Newby, MD Lincoln Smith, MD Developmental Pediatrics Gwen M. Glew, MD Emergency Medicine Jennifer R. Reid, MD Elena Shephard, MD Kimberly Stone, MD Endocrinology Harvey K. Chiu, MD Tracy A. Hentz, MD Monica S. Thakar, MD Elizabeth Villavicencio, MD, PhD Jessica Wright, MD Pathology Infectious Disease Soren Gantt, MD Oscar G. Gomez, MD, PhD Jin-Young Han, MD Nada Harik, MD William J. Muller, MD, PhD Audrey R. Odom, MD Angela J. Peck, MD Thor A. Wagner, MD Medical Genetics 238 Stacey Berry, MD Psychiatry and Behavioral Medicine Paul A. Boutin, MD Alison A. Golombek, MD Ray Hsiao, MD Jeffrey Kaiser, MD Kari L. Kawakami, MD Catherine Kuniyoshi, MD Jon Kuniyoshi, MD Jennifer K. Shannon, MD Heather C. Mefford, MD, PhD Pulmonary Neonatology Maneesh Batra, MD Pamela Statler Chapman, MD Marcella Mascher-Denen, MD Katherine Salinas, MD Nephrology Amanda D. Bunn, MD Kera E. Luckritz, DO David Simon, MD Amy O. Staples, MD Priya Verghese, MD Ikuyo Yamaguchi, MD Hematology/Oncology Scott C. Borinstein, MD Eric J. Chow, MD Scott J. Diede, MD, PhD Jacob R. Garcia, MD Sonia Partap, MD Randal C. Richardson, MD, MMS Stephanie A. Robinett, MD Neurology Mario T. Coleman, MD Jessica R. Litwin, MD Ian Miller, MD SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Danny W. Hsia, MD Radiology Amaya Ormazabal, MD Muzaffer Tepe, MD Mahesh Thapa, MD Rheumatology Sarah Ringold, MD Jennifer K. Turner, MD Surgery Tracy Grikscheit, MD Andrew M. Schulman, MD Urology Margarett Shnorhavorian, MD Seattle Children’s Hospital Residents Chief Residents R2 R3 Sarah E. Archibald, MD Douglas J. Opel, MD Josh D. Weldin, MD Francois P. Aspesberro, MD Janna P. Bakari, MD Crystal M. Benson, MD Amy E. Carter, MD Aaron M. Dalan, MD Stephen E. Darling, MD Sarah A. Denny, MD Kelly N. Evans, MD C. Esen Garner, MD Eric A. Gustafson, MD Matthew A. Haemer, MD Susan M. Halbach, MD Elizabeth N. Jacobson Misbe, MD Kimberly M. Johnson, MD Jeremy D. Kassebaum, MD Scott H. Maurer, MD Erica A. Michiels, MD Eva M. Moore, MD Mary F. Murdoch, MD Jessica E. Pittman, MD Camilla A. Richmond, MD Amanda M. Striegl, MD Annika K. Sutton, MD Sarah K. Taylor, MD Ildiko H. Thomas, MD Melissa C. Walsh, MD Victoria L. Wilkins, MD Holly C. Carey, MD Eleanor S. Click, MD John D. Cowden, MD Sara P. Dow, MD H. Mollie Greves, MD Evelyn K. Hsu, MD Kristin E. Hubert, MD Matthew P. Kronman, MD Ellen A. Lipstein, MD Kira E. Marciniak, MD Anjuli K. Mehrotra, MD Kristin C. Nyweide, MD Maren E. Olson, MD Zakiya M. Pressley, MD Alison E. Scott, MD Heather L. Silverberg, MD Kevin M. Sullivan, MD Wendy Sue Swanson, MD Rupin R. Thakkar, MD M. Gregory Thompson, MD Natalie A. Vogel, MD R1 Mikelle D. Bassett, MD Andrew C. Beckstrom, MD Rachel S. Bercovitz, MD Omar J. Bhutta, MD Matthew S. Blessing, MD Ann E. Dahlberg, MD J. Wesley Diddle, MD Andrew C. Dietz, MD Yolanda N. Evans, MD Reid W. Farris, MD Rachel A. Fleishman, MD Erica R. Freeman, MD Alana S. Golden, MD Sabrina E. Guse, MD Hiwot Hiruy, MD Benjamin K. Jackson, MD Katie M. Kazmier, MD Malaika L. Little, MD Nicolas L. Madsen, MD Jennifer A. Montoya, MD Lila N. O’Mahony, MD Jeffrey P. Otjen, MD Vijaya L. Soma, MD Kristina A. Toncray, MD Kathryn M. Wheeler, MD Amie C. Wu, MD Garland G. Youngblood, MD SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 239 Financial Summary Fiscal Year 2004 – 2005 O P E R AT I N G R E V E N U E S A N D E X P E N S E S F O R T H E CONTRIBUTIONS TO CHILDREN’S F I S C A L Y E A R O C T. 1 , 2 0 0 4 – S E P T. 3 0 , 2 0 0 5 Sources of Contributions DOLLARS IN THOUSANDS 4% Organizations & Other Donors* CHILDREN’S HEALTH CARE SYSTEM 1% Children’s Thrift Stores 12% Corporations Sources of Revenues Patient Service Revenues Research and Other Government Grants Other Revenues Uncompensated Care Donations Unrestricted Donations and Restricted Donations Used in Operations Investment Income Total Sources of Revenues $390,433 36,150 22,182 12,802 18,864 22,946 $503,377 19% Guild Projects 56% Individuals 8% Foundations * This category includes donations from service groups (such as Elks, Kiwanis, Foresters) as well as workplace campaigns and non-guild special events. Uses of Contributions Uses of Revenues Uncompensated Care Salaries and Benefits Supplies and Other Expenses Depreciation and Interest Provision for Renovation, New Equipment and New Programs Total Uses of Revenues $35,833 198,960 166,614 36,234 65,736 $503,377 14% Greatest Need (unrestricted gifts) 1% Facilities & Equipment 17% Fundraising & Administration 35% Uncompensated Care 15% Research Volunteers An average of 1,333 people contributed time and services each month for a total of 127,400 work hours in 2005. Here’s where they spent their time: CHILDREN’S HOSPITAL FOUNDATION, GUILD ASSOCIATION AND RETAIL Sources of Revenues Fundraising Revenues and Support Children’s Retail (net revenues from thrift stores) Subtotal 18% Patient Care & Hospital Programs $38,766 339 $39,105 2% Patient Care, Outpatient 30% Patent Care, Inpatient 39% Thrift & Gift Shops Expenses Fundraising and Administrative Expenses Total Net Revenue 240 (–) 6,802 $32,303 SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 29% Support Services Financial Summary 2005 PATIENT STATS STAFF STATS > 215,051 total patient visits (76,000 individual patients) – 165,192 appointments in our outpatient clinics – 29,497 visits to the emergency room – 11,608 admissions to the hospital – 8,754 short-stay visits > 250 patient beds > 5.7 days average length of stay > 4,351 inpatients who had surgical procedures > 5,831 ambulatory patients who had surgical procedures > 74,268 diagnostic imaging tests performed > 904,198 lab tests performed Where Our Inpatients Come From 5% Alaska, Montana & Idaho 1% Outside Washington, Alaska, Montana & Idaho 19% Seattle 43% Other Washington Locations 32% Other King County Locations AS OF JAN. 2, 2006 > 3,450 active staff employed at Children’s > 970 active medical staff – 460 hospital-based physicians – 95 hospital-based mid-level health professionals – 415 community members of our medical staff RESEARCH FUNDING Sources of Extramural Funding In 2005 our grant and contract revenue (exclusive of philanthropic gifts) totaled in excess of $25 million. Federal grants accounted for 68% of the total revenue. Included in this federal figure is more than $11 million of National Institutes of Health (NIH) funding where Seattle Children’s was the prime recipient of the NIH award. This NIH funding to Seattle Children’s Hospital in 2005 increased by 20% compared to 2004. Based on NIH award data for 2005, Seattle Children’s Hospital ranked 11th in its peer group. 0% Other ($-) 22% Foundation ($5,781,515) Where Our Physicians Travel to Provide Care 10% Corporate ($2,563,288) (total of 350 clinic days) 6% Kennewick, Wash. 20% Wenatchee, Wash. 68% Federal ($17,363,941) 9% Other Washington, Alaska, Montana & Idaho Locations 40% Anchorage & Other Alaska Locations 25% Yakima, Wash. SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON 241 Acknowledgments Thank you Annual Report Leadership Editorial and Production Team A special thank-you to the following individuals who assisted with this report Kathi Elliott Patricia Adams Gretchen Anderson Emily Andrews David Barry Diana Baker Karen Barket Allory Bauer Kathleen Beaudry Shanda Boyle Mary Brown Amy Cheney E. Chappie Conrad, MD Sandy Craig Gordy Darragh Marti Davis Barb Droppleman Scott Ford Brooke Freed Millie Gregory Amy Grover Marivic Guevarra Sandy Heatley Nancy Henry Cary Holder Thomas N. Hansen, MD President, Chief Executive Officer James Hendricks, PhD Vice President, Research Jennifer Fisch F. Bruder Stapleton, MD Senior Editor/Writer Marketing Communications Pediatrician-in-Chief Chairman, Department of Pediatrics, University of Washington School of Medicine Lisa Brihagen Writer Marketing Communications Robert Sawin, MD Tina Russell Surgeon-in-Chief Vice Chairman, Department of Surgery, University of Washington School of Medicine Production Coordinator Margaret Foster 242 Production Supervisor Marketing Communications Phinney/Bischoff Design House Design Project Manager and Content Manager Marketing Communications Studio Bolo Jordis Ruhl Richard Johnson Project Consultant Editor Produced by the Marketing Communications Department, Seattle Children’s Hospital and Regional Medical Center, Seattle, Washington Marge Manwaring Susan Macek Nancy LeVine Interim Director Feature Photographer Production and Design Copyeditor/Proofreader Lisa McCoy Copyeditor/Proofreader SEATTLE CHILDREN’S HOSPITAL SEATTLE, WASHINGTON Mildred Hill Angel Hui Kaitlin Jaccard Casey Jones Holly Kaopuika Jason Lane Joan Laughlin Tri Le Stephanie Leak Amy Leska Fran McKee Michelle Metcalf Richard Molteni, MD James Parr Sean Poppoff Joann Ramezanzedeh Lynn Rise Denise Robinson Lisa Robinson Anne Thompson Ellen Veum Christy Villareal Bryan Williams, MD Chris Wong Seattle Children’s Hospital and the Department of Pediatrics, University of Washington School of Medicine Seattle Children’s Hospital and the Department of Pediatrics, University of Washington School of Medicine 2005 Academic Annual Report 2005 Academic Annual Report 4800 Sand Point Way N.E. Seattle, Washington 98105 (206) 987-2000 www.seattlechildrens.org В© 2006 Children’s Hospital and Regional Medical Center, Seattle, Washington. All rights reserved. 10/06 Our Vision We will be the best children’s hospital Our Mission WE WILL: > Provide patients and their families excellent care with compassion and respect We believe all children have unique needs and should grow up without illness or injury. With the support of the community and through our spirit of inquiry, we will prevent, treat and eliminate pediatric disease. > Deliver superior, accessible, cost-effective service > Attract and retain the best talent at all levels of the organization > Be one of the top five pediatric research institutions in the country > Be the nation’s premier pediatric educator > Achieve worldwide prominence by integrating patient care, research, education and advocacy Our Vision We will be the best children’s hospital WE WILL: > Provide patients and their families excellent care with compassion and respect > Deliver superior, accessible, cost-effective service > Attract and retain the best talent at all levels of the organization > Be one of the top five pediatric research institutions in the country > Be the nation’s premier pediatric educator > Achieve worldwide prominence by integrating patient care, research, education and advocacy
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