Clinical Care • Research • Education • Advocacy
table of contents
department of pediatrics
Letter from the Chair....................................... 2
SECTIONS
Pediatric Hospital Medicine.............................. 97
Administration and Funding.......................... 4
Adolescent Medicine........................................... 38
Departmental Mission Summary
Allergy, Immunology and
Rheumatology.................................................. 39
Prevention Research Center
for Family and Child Health......................... 99
Clinical Services Summary...........................................6
Cardiology................................................................ 41
Research Summary .....................................................12
Education Summary.....................................................16
Child Heath Associate/
Physician Assistant Program....................... 45
Advocacy Summary.....................................................19
Child Neurology..................................................... 46
International Activities Summary...........................21
Clinical Genetics and Metabolism.................. 50
Department Features
Community Pediatrics......................................... 54
Critical Care Medicine.......................................... 56
Pulmonology.........................................................101
PROGRAMS
Center for Bioengineering...............................105
Center for Human Nutrition...........................106
Children’s Outcomes Research
Program.............................................................108
Clinical Trials Organization..............................113
Colorado Pediatric Stroke Program.............114
Colorado Clinical and Translational
Sciences Institute..........................................................23
Dermatology........................................................... 59
Gastrointestinal Eosinophil
Diseases Program..........................................................26
Developmental and Behavioral
Pediatrics............................................................. 60
Gastrointestinal Eosinophil Center..............118
Faculty Information Database Online (FIDO).....28
Developmental Biology...................................... 62
Intellectual and Developmental
Disabilities Research Center......................119
Electronic Medical Record System.........................30
Emergency Medicine........................................... 64
Linda Crnic Down Syndrome Institute.................33
Endocrinology........................................................ 66
Notables
St. Geme Lectureship...................................................34
Four Faculty Members Honored
During Annual Pediatric Academic
Societies Meeting..........................................................36
Epidemiology.......................................................... 69
Gastroenterology, Hepatology
and Nutrition..................................................... 70
General Academic Pediatrics............................ 74
Hematology, Oncology and
Bone Marrow Transplantation................... 77
Festschrift Symposium for
M. Douglas Jones, Jr., MD.....................................36
Infectious Diseases............................................... 82
Sections, Programs, and Affiliates............... 37
Awards and Honors ..................................... 147
Kempe Center for the Prevention
and Treatment of Child Abuse
and Neglect........................................................ 85
Publications.................................................. 159
Neonatology........................................................... 89
Research Funding........................................ 235
Nephrology.............................................................. 93
Clinical Faculty, Residents, and Fellows.... 293
Nutrition.................................................................... 94
Colorado WIN Partners.....................................116
JFK Partners...........................................................121
Pediatric Heart Lung Center...........................124
Perinatal Research Center................................126
The Children’s Hospital Clinical
Translational Research Center..................129
The Children’s Hospital
Research Institute..........................................132
The Children’s Hospital
Sleep Center.....................................................134
AFFILIATES
Barbara Davis Center
for Childhood Diabetes...............................137
Denver Health.......................................................142
National Jewish Health.....................................145
Career Teaching Scholar Awards................ 301
Endowments................................................. 302
Acknowledgements..................................... 306
2006-2008 Departmental Report
1
L etter fr o m the C ha i rman and the C E O
“We continue to develop the
next generation of leadership
by cultivating and implementing cutting-edge educational
initiatives in support of our
medical students, physician
Stephen Daniels, MD, PhD, and James Shmerling, DHA, FACHE
assistant students, residents,
Dear Friends of Pediatrics,
and fellows. "
W
e are pleased to present the Department of Pediatrics’ Departmental Report,
a comprehensive review of our accomplishments during the past three years
in our clinical, research, education, international health, and advocacy pro-
grams—all of which are crucial in supporting The Children’s Hospital’s mission to
advance pediatric health care.В В SinceВ 2006В the Department has experienced strong growth in several important
areas. Our faculty increased to more than 500 members, a deepening of our talent pool that has resulted in significant program expansion in the basic sciences and
in clinical, translational, and outcomes research. These reenergized and expanded
research initiatives hold much promise for improving the lives of children everywhere
and have gone far in solidifying the Department’s local and national prominence.
В Our faculty members are national leaders in education and advocacy. In that tradition, we continue to develop the next generation of leadership by cultivating and
implementing cutting-edge educational initiatives in support of our medical students,
physician assistant students, residents, and fellows. As an important adjunct to these
efforts, our faculty members remain committed to advocating for child-health issues
at the state, national, and international levels.
2 Department of Pediatrics
В Our Department of Pediatrics continues to foster landmark program development,
including our nationally renowned stem-cell research initiative. In late 2008, Bruce
Appel, PhD,В DirectorВ of theВ Program of Pediatric Stem Cell Biology, Department of
Pediatrics, was named the Diane G. Wallach Chair in Pediatric Stem Cell Biology.
Dr. Appel is partnering with theВ UniversityВ of Colorado Denver and Dennis Roop,
PhD,В who is the Charles C. Gates Chair of Regenerative Medicine and Stem Cell
BiologyВ and the Director of the Regenerative Medicine and Stem Cell Biology
Program. Together,В they will open up new and exciting research avenues in this
crucial area of disease prevention, diagnostics, management, and treatment.
 The September 2007 transition to The new Children’s Hospital and our shared
medical campus provided an opportunity to develop Children’s strategic plan in collaboration with the University of Colorado Denver—an ambitious plan that will serve
as a pediatric operational and service excellence blueprint. These clinical, education,
and research guideposts include developing nationally prominent clinical, educational,
and research programs and dramatically increasing National Institutes of Health
(NIH) funding during the next five to seven years. “The Children’s Hospital and
the Department of Pediatrics
marked a major milestone
by securing more than
$44.5 million in peer-reviewed
 Toward that specific research-funding goal, The Children’s Hospital and the
Department of Pediatrics marked a major milestone by securing more than $44.5
million in peer-reviewed awards from the NIH during 2008—ranking first among all
awards from the NIH
during 2008.”
medical school-based Departments of Pediatrics in NIH awards. This is a remarkable
achievement that underscores the Department’s position on the forefront of pediatric
research.
 The current downturn in the nation’s and the world’s economies poses a major
challenge to the efforts outlined in this letter. Regardless of the circumstance or challenge, the Department of Pediatrics will continue to build upon its long-standing tradition of excellence in the cause of children’s health. Our success and strength is founded on Children’s robust 100-year history, coupled with outstanding faculty, excellent
collaboration, the best hearts and minds, and a continued dedication
to our mission.
В Sincerely,
В Stephen R. Daniels, MD, PhD
James E. Shmerling, DHA, FACHE
Professor and Chairman, Department of Pediatrics
President and Chief Executive Officer
University of Colorado Denver School of Medicine
The Children’s Hospital
Pediatrician-in-Chief and
L. Joseph Butterfield Chair in Pediatrics
The Children’s Hospital
В 2006-2008 Departmental Report
3
department of pediatrics administration
Department of Pediatrics Administration Front row, l - r: Jennifer Ackerman, Shelia Sloan, Barbara Falk, Elizabeth Ayala, Jeff Holmes;
Second row, l - r: Lori Sanchez, Rhonda Buckner, Martha Huckaby, Bobbi Siegel, Deborah McMillen; Third row, l - r: Helen Porter, Robert Stiner,
Susan Hotchkiss, Gail Cohen, Audrey Wen, Patrick Micone; Back row, l - r: Jeffrey Loker, Lindsay Martin, Peg Christon, Stephen Daniels,
Michael Clark, Jessica Jensen
Department of Pediatrics
Administration
T
tinuing medical education activities, faculty retreats,
alumni reunions, physician recognition activities, and
he Department of Pediatrics’ administrative office is
departmental reports. The Department has also devel-
responsible for overseeing the financial management
oped, implemented, and maintains an automated annual
and administration of the Department of Pediatrics
review process called “FIDO” – Faculty Information
within the University of Colorado Denver and the
Database Online. FIDO is a robust Web-based soft-
Pediatrician-in-Chief Division of The Children’s Hospital.
ware tool created and managed by the Department of
This includes the coordination of policies and pro-
Pediatrics. In addition to automating the review process,
cedures and the oversight of educational, research, and
FIDO has become a valuable source of data for the
clinical programs within the Department. Additional
Department. Each year FIDO is enhanced and upgraded
business operations include grants administration;
to become even more valuable, and the hope is to
human resource and salary administration; academic
continue to expand the data collected into other
appointments, promotions, and reviews (for both full-
applicable areas.
time and clinical faculty); clinical practice plan manage-
The administrative office is currently comprised of
ment; administrative support; and Web site and Web
21 staff members, plus the Chairman and Pediatrician-
applications development and administration. Other
in-Chief, Stephen Daniels, MD, PhD, who support
ongoing special projects include coordination of con-
approximately 500 faculty, 458 clinical faculty, and
4 Department of Pediatrics
department of pediatrics administration
Faculty Salary Sources (In Millions)
close to 450 additional administrative and research
support personnel, including 182 professional research
assistants and associates employed by four different
human resource systems (22 paid clinical faculty, 43
2005–2006
state classified, 50 exempt professionals, 18 postdoctoral
17%
fellows, 126 hourly employees and 15 work-study stu-
25%
4%
3%
dents). The Department also manages an annual budget
of approximately $75 million, which includes profes-
51%
sional fee income, grant and contract revenues, state
appropriated funds, restricted funds, and other sources.
Department of Pediatrics Administration Faculty and Staff
Stephen R. Daniels, MD, PhD
Professor and Chairman
Department of Pediatrics
University of Colorado Denver School of Medicine
Pediatrician-in-Chief and
L. Joseph Butterfield
Chair in Pediatrics
The Children’s Hospital
Jennifer Ackerman
Financial Manager
Elizabeth Ayala
Executive Assistant
Rhonda L. Buckner
Executive Assistant
Peg Christon, MD, MSCIS
Director, Faculty Information Database On-Line (FIDO)
Michael Clark
Grants and Contracts Administrator
Gail Cohen
Administrator, Department of
Pediatrics and Pediatrician-in Chief Division
Susan Hotchkiss
Office Clinic Supervisor
2006–2007
28%
Martha M. Huckaby, MSW
Administrative Assistant
26%
5%
Jessica Jensen
Administrative Assistant
4%
Jeffrey L. Loker
LAN Administrator
37%
Lindsay Martin
Financial Analyst
Deb McMillen
Academic Affairs Coordinator
2007–2008
Patrick Micone
Manager and Grants Specialist
26%
25%
Helen Porter
Web Administrator
Lori Sanchez
Grants Specialist
6%
4%
39%
Bobbi Siegel, MSW
Assistant to the Chairman
Shelia Sloan
Payroll Manager
Barbara Falk
Assistant on Special Projects
Robert M. Stiner, MDiv
Grants Specialist
Jeff Holmes
Senior Software Developer
Audrey Wen
Grants Specialist
2005–2006
2006–2007
2007–2008
Extramural
$9.62
$9.63
$9.33
State
$1.64
$1.64
$1.52
$20.27
$12.68
$14.42
$1.36
$1.23
$2.05
Clinical
Other
TCH
TOTAL
$6.49
$8.63
$9.30
$39.38
$33.81
$36.62
2006-2008 Departmental Report
5
departmental mission summary
clinical
summary
The Department of Pediatrics at the University of Colorado Denver School of Medicine offers
a breadth of clinical services, with a depth of expertise in primary care and every pediatric
medical subspecialty. Pediatric and subspecialty care provided by Department of Pediatrics
faculty has an outstanding national clinical reputation.
T
he move of The Children’s Hospital to its new loca-
America’s Best Children’s Hospitals listing. Of the 98
tion has increased our ability to provide excellent clin-
pediatric hospitals surveyed, The Children’s Hospital
ical care. The new Children’s Hospital, which opened
was named to U.S. News & World Report’s first-ever
in September 2007, is on 48 acres and is located on
Best Children’s Hospitals’ Honor Roll of 10 elite
the same campus as the newly built Anschutz Medical
pediatric hospitals that achieved ranked status in all
Campus, which is also the home of the University of
10 specialty areas. In addition, The Children’s Hospital
Colorado Denver School of Medicine and University of
ranked in the top 10 for 6 specialty areas, including the
Colorado Hospital. The new Children’s Hospital spans
following: Digestive Disorders #5, Respiratory Disorders
1.44 million square feet, including a 294-bed inpatient
#5, Neonatology #8, Orthopedics #8, Cancer #10, and
facility, outpatient buildings, an administrative building,
Diabetes #10.
And Parents magazine has recognized The Children’s
and a conference center.
The Children’s Hospital strategic plan calls for
Hospital as one of the United States’ top pediatric
collaborative growth. In order to improve clinical effi-
hospitals in its inaugural survey, “10 Best Children’s
ciencies and provide better service to patients, families,
Hospitals.” Parents surveyed more than 100 children’s
and referring physicians, service lines have been formed
hospitals to determine where the more than three mil-
in the following areas: The Heart Institute, Digestive
lion children hospitalized each year receive the best care
Health, Neurosciences, the Center for Cancer and
possible. In the specialty-area rankings, The Children’s
Blood Disorders, the Breathing Center, and Maternal
Hospital ranked 2nd in pulmonary care; 7th in ER
Fetal Medicine.
care; and 9th in orthopedic care. We ranked 10th for
Ongoing recruitment of faculty in several areas will
overall care.
Since 2006, a number of important new multidis-
expand access opportunities in local, satellite, and
regional locations and continue to strengthen the rela-
ciplinary clinical programs have been developed or
tionship between the University of Colorado Denver
enhanced. These new programs include:
School of Medicine and The Children’s Hospital.
n
Gastrointestinal Eosinophilic Diseases Program:
In the spring of 2009, the Department of Pediatrics
A multidisciplinary program started in December of
ranked 8th among pediatric programs at U.S. medical
2007, where children with eosinophilic gastrointesti-
schools by U.S. News & World Report in their annual
nal diseases are cared for in one comprehensive clinic
guide to America’s best graduate schools. The rating is
by board-certified pediatric gastroenterologists and
based on input from 128 medical school and osteopath-
allergists, as well as psychosocial and behavioral clini-
ic deans, deans of academic affairs and heads of internal
cians, nutritionists, and pediatric feeding specialists.
medicine or the directors of admissions.
The Children’s Hospital has once again been honored
Pediatric and Adult Congenital Arrhythmia Center:
n
The Arrhythmia Center provides evaluation and ther-
as one of the nation’s top 10 hospitals following the
apy for patients with signs or symptoms suggestive of
recent release of U.S. News & World Report 2009
a cardiac rhythm abnormality. The Center has a very
6 Department of Pediatrics
clinical summary
busy electrophysiology laboratory providing state-of-
Anna and John J. Sie Center for Down Syndrome:
n
the-art technologies in the areas of ablation and elec-
The Children’s Hospital announced July 30, 2008, trophysiology device implantation and management.
the receipt of a multimillion dollar gift from the
Anna and John J. Sie Foundation that will go toward
Alternative and Complementary Medicine: Current
n
services include outpatient consultation in Integrative
the establishment of the Anna and John J. Sie Center
Medicine, Integrative Psychiatry, and Acupuncture.
for Down Syndrome, the first of its kind in the
For inpatients, the program offers Healing Touch
Rocky Mountain Region. The center will provide
and an expanded spirituality program.
state-of-the-art medical care to children with Down
syndrome, provide up-to-date information on Down
syndrome to women who have received a prenatal
Developmental and Behavioral Pediatrics
diagnosis of Down syndrome, and participate in col-
Autism Treatment Network Clinics: Started in June
n
laborative ground-breaking clinical trials.
2008, these clinics are dedicated to improving medical care for children with autism spectrum disorders
(ASD). This is one of 15 sites around the country.
Neurosciences (newly organized)
These clinics include developmental and behavioral
n
Colorado Pediatric Stroke Clinic: A bi-monthly clinic
pediatricians, psychologists, speech and occupational
provides multidisciplinary services – including neurol-
therapists, with consultation from genetics, neurol-
ogy, hematology, rehabilitative services, and neurop-
ogy, gastroenterology, and sleep medicine in order to
sychology – to patients and families with stroke and
provide more integrated care for children with ASD.
stroke-like syndromes.
eXtraordinarY Kids Clinic: A multidisciplinary clinic
n
Epilepsy Clinic: Provides expert comprehensive care
n
started in 2007 that includes a developmental and
to children who suffer from seizures. Patients range
behavioral pediatrician, endocrinologist, psycholo-
from children with new onset seizures to those with
gists, and speech and occupational therapists. This
medically intractable epilepsy. A full range of treat-
clinic addresses the medical, endocrine, developmen-
ment options – including epilepsy surgery, dietary
tal, and psychological needs of children and ado-
therapy, and clinical trials in new therapeutic agents –
lescents with XXY (Klinefelter syndrome), XXYY,
is offered.
Triple X, XYY, and other X and Y chromosome
General Child Neurology Clinic: Evaluates, consults,
n
variations. This is the only program in the country
and manages children with disorders of the central
that is this comprehensive.
and peripheral nervous systems, providing neurologi-
Fragile X Clinical and Research Consortium Clinic:
cal consultation, ongoing care and diagnostic services
A multidisciplinary team that specializes in treating
to identify, characterize, and treat disorders in infancy,
individuals with Fragile X syndrome and is a member
childhood, and adolescence, including seizures and
of the National Fragile X Foundation’s Clinics and
epilepsy, headache/migraines, neuro-metabolic, neuro-
Research Consortium, which has 19 sites around the
genetic, and neuromuscular diseases.
n
country.
Clinica del Desarolle: A multidisciplinary clinic that
n
Headache Clinic: Provides comprehensive multidisci-
n
plinary health care of the highest quality to children
includes a developmental and behavioral pediatrician,
with headache disorders. Additionally, the providers
psychologist, and speech and occupational therapists.
in this clinic are actively pursuing research into the
The clinic evaluates children who are monolingual
cause and treatment of headache disorders.
Spanish speakers.
2006-2008 Departmental Report
7
clinical summary
9th Floor Inpatient Sitting Area, The Children’s Hospital
Movement Disorders: A monthly clinic provides con-
n
Breathing Center
sultative services for the diagnosis and management
This Center has recently been developed to serve as an
of complex pediatric movement disorders.
umbrella service line for many of our excellent pulmo-
Tuberous Sclerosis Clinic: Provides comprehensive
n
nary programs; to enhance communication between
multidisciplinary health care of the highest quality to
the outpatient clinic and a new 24-bed inpatient unit;
children with tuberous sclerosis complex (TSC), as
to enhance multidisciplinary care and efficiency; and
well as clinical research of TSC.
to improve clinical outcomes. Included in this program
Multidisciplinary Muscle Clinic: A weekly clinic pro-
are cystic fibrosis, asthma, ventilator care, sleep, general
vides diagnosis and management of neuromuscular
breathing problems, as well as a Pulmonary Diagnostic
diseases by a multidisciplinary team consisting of
Center and an Interstitial Lung Disease Program.
providers from neurology, rehabilitative services, and
n
n
Ventilator Care Program: A comprehensive, multi-
genetics as well as representatives from the Muscular
disciplinary program to improve the quality of care
Dystrophy Association.
of children with chronic respiratory failure who
Neuropsychology Services: The neuropsychologists
n
require prolonged ventilator support. The mission is
provide consultation and evaluation of cognitive
to enhance long-term outcomes and provide better
functioning; assess the risk for increased cognitive
services for children with chronic ventilator-depen-
difficulties associated with the progression of disease
dent lung disease and their families, and to enhance
and subsequent to treatment; and recommend appro-
research and training and education of health care
priate interventions.
providers. This program includes inpatient and
8 Department of Pediatrics
clinical summary
outpatient care and includes patients in the neonatal intensive care unit, pediatric intensive care unit,
W
ith the growth of our clinical programs, the
Department of Pediatrics faculty has increased as
cardiac intensive care unit, and on the ward. The
well, from 250 in 2006 to more than 500 today. Our
Ventilator Care Program also includes management
faculty members provide clinical care, research, and
and care of children in the new Pediatric Respiratory
educational excellence in virtually all pediatric sub-
Care Unit (PRCU).
specialties. Additionally, our physicians and health care
The Children’s Hospital Sleep Center: A multidisci-
n
professionals travel to more than 400 outreach clinic
plinary program jointly administered by the depart-
locations in 30 sites each year in Colorado and sur-
ments of Pulmonology and Otolaryngology that
rounding states.
works in close collaboration with the departments
New physician leadership in the areas of Emergency
of Child Neurology, Psychology, and Adolescent
Medicine, Hematology, Oncology and Bone Marrow
Medicine. The center provides comprehensive clinics
Transplantation, Developmental and Behavioral
to evaluate patients presenting with behavioral and
Pediatrics, and Child Neurology recently have been
medical sleep and breathing disorders and to make
recruited. Clinical leaders in the Department of
appropriate treatment recommendations. The care
Pediatrics have developed strategic visions for each of
team assists primary care physicians and specialists
their programs that are consistent with The Children’s
with the diagnosis and treatment of apnea, and other
Hospital strategic plan and which uphold the missions
sleep and breathing disorders in infants, children,
of both the University of Colorado Denver School of
and adolescents.
Medicine and The Children’s Hospital.
The Department and The Children’s Hospital are
Hospitalist Program
partners in advancing the quality and safety of care
In early 2007, The Children’s Hospital implemented a
provided to our patients and their families. In 2008,
Hospitalist program. The Hospitalists enhance and sup-
Daniel Hyman, MD, was recruited to serve in a newly
port the communication between physicians, patients,
created role of Chief Quality Officer. This new posi-
families, nursing staff, ancillary services, and referring
tion is emblematic of the organization’s commitment
providers. Care is provided at the main Children’s
to continuously improve the quality of care and health
Hospital campus, as well as at our Network of Care
outcomes of children in Denver and the entire region.
inpatient sites.
Efforts in 2009 have included reductions in infection,
improvements in medication safety, andВ enhanced team-
Network of Care
The Network of Care provides patients and families
work and communication.
In November 2008, The Children’s Hospital and
with convenient access to Children’s pediatric experts
University of Colorado Hospital signed a Letter of
and facilities built just for kids that are closer to home.
Intent to develop a preeminent maternal-fetal/neonatal
The Children’s Hospital now has 15 locations for pedi-
medicine program to be housed at Children’s, thereby
atric emergency care, urgent after-hours care, pediatric
realizing one of the prime benefits of the combined
specialists, therapy care, and more, with two new loca-
medical campus. This partnership will advance exist-
tions at Exempla Saint Joseph Hospital and the North
ing mother-baby services to provide unparalleled care
Campus in Broomfield and a partnership with Memorial
and treatment for high-risk moms and their newborns
Hospital for Children in Colorado Springs.
in a dedicated mother/baby facility that will eventually
2006-2008 Departmental Report
9
clinical summary
serve as a local, regional, and national referral cen-
The Children’s Hospital Emergency Medicine
ter. Until this new facility is built, these services will
Department serves as the region’s only Level 1 Regional
continue to be provided by our high-risk mother/baby
Pediatric Trauma Center, delivering high-quality emer-
teams through the Colorado High-Risk Maternity and
gent and urgent care 24 hours a day, 7 days a week
Newborn Program.
to an enormous geographic area that extends beyond
The Children’s Hospital and Department of Pediatrics
have had a long-term commitment to integrating primary care for low-income children with the academic
Colorado to Wyoming, Montana, South Dakota,
Nebraska, Kansas, and New Mexico.
The faculty is also responsible for The Children’s
missions of training and clinical research. Currently, two
Hospital community-based Network of Care, provid-
operational primary care clinics provide general academ-
ing medical direction and clinical coverage in several of
ic pediatric care: the Child Health Clinic and the Special
the community sites, including 24 hours a day, 7 days a
Care Clinic.
week urgent/emergent care in three facilities and after-
The Child Health Clinic at Children’s delivers lon-
hours urgent care at two facilities beyond the main cam-
gitudinal, comprehensive primary care for underserved
pus. This model allows us to bring pediatric expertise in
children. Caregivers in the clinic see 19,000 patient visits
the emergent management of many conditions directly
per year. Many of the patients have chronic illnesses
into well-equipped, free-standing centers, as well as to
such as asthma, seizures, and behavioral problems
several community hospital partners.
and therefore have a higher level of medical need. The
The faculty is responsible for the direction of the
Special Care Clinic at Children’s offers comprehensive
Centura/Flight for Life pediatric transports and provides
primary and consultative care to children with special
24 hours a day, 7 days a week phone consultation to
health needs, including children with developmental dis-
primary care providers and emergency departments
abilities, genetic disorders, chronic medical problems,
throughout the region.
and prematurity.
The Children’s Hospital also offers the full comple-
The Department of Pediatrics has experienced an
ongoing shift from an inpatient to an outpatient-based
ment of outpatient subspecialty care at the main campus
practice of medicine. As a result, the total number of
and throughout the Network of Care locations.
outpatient clinic visits to Department of Pediatrics fac-
In addition to general medical units, inpatient care
ulty in facilities operated by The Children’s Hospital
is provided in The Children’s Hospital’s Pediatric
continues to increase. In 2006, the total number of
Intensive Care Unit (PICU), Newborn Intensive Care
outpatient visits – including visits to the main campus,
Unit (NICU), Cardiac Intensive Care Unit (CICU), TCH
seven Network of Care locations, and regional loca-
Clinical and Translational Research Center (formerly
tions – was 241,660. In 2007, total outpatient visits
pediatric General Clinical Research Center), and the
were 250,419. The main campus and Network of
new Pediatric Respiratory Care Unit (PRCU). Faculty
Care experienced significant changes in 2007, with the
members also provide care at the University of Colorado
move of The Children’s Hospital to its new location
Hospital’s Newborn Intensive Care Unit and several
on the Fitzsimons Medical Campus, the addition of a
Level II units in 12 community hospitals.
Dermatology practice at the main campus, the opening
10 D e p a r t m e n t o f P e d i a t r i c s
clinical summary
of a new Network of Care location in Wheat Ridge, and
The Department of Pediatrics provides outstanding
a new Sports Medicine Program at the Parker Network
clinical care for pediatric patients in Colorado and the
of Care location. By 2008, overall outpatient visits to
Rocky Mountain Region. As the reputation of the care
the main campus, 14 Network of Care locations, and
we provide expands, we receive an increasing number
regional locations was 282,451, a 13 percent increase
of referrals from across the United States. The partner-
in just one year. And Children’s now offers more than
ship between the Department of Pediatrics and The
15 different pediatric specialties at its Network of Care
Children’s Hospital ensures that this growth in clinical
locations. In 2006, inpatient yearly admissions totaled
programs will continue and that the quality of care will
2,811. In 2007 inpatient admissions numbered 2,978.
remain among the best in the world.
And in 2008 total inpatient yearly admissions had
increased to 3,530.
The Children’s Hospital Network of Care
N
W
E
S
1
BROOMFIELD
M
BOULDER
L
SUPERIOR
1
7
est Pkwy
Northw
2
E470
THORNTON
The Children’s Hospital North Campus,
Broomfield
120th Ave
WESTMINSTER
2
3
104th Ave
COMMERCE CITY
270
ARVADA
3
GOLDEN
PeГ±a Blvd
36
93
Care by The Children’s Hospital
at Lutheran, Wheat Ridge
4
76
25
The Children’s Hospital Therapy Center,
Westminster
5
6
7
KidStreet, Denver
8
The Children’s Hospital Center for Cancer
and Blood Disorders, Littleton
9
The Children’s Hospital Pulmonary Care,
Centennial
70
5
WHEAT RIDGE
D
4
Colfax Ave
70
DENVER
E
AURORA
A
Colorado Blvd
6
85
470
6
8
7
11
E470
10
11
Care by The Children’s Hospital, Littleton
Children’s After Hours Care at
Littleton Adventist Hospital, Littleton
Care by The Children’s Hospital,
Centennial
The Children’s Hospital
South Surgery Center, Lone Tree
The Children’s Hospital Parker Campus
– The Children’s Hospital at Parker Adventist
– Care by The Children’s Hospital, Parker
– The Children’s Hospital Therapy Center, Parker
CENTENNIAL
L
9
LONE TREE
HIGHLANDS
AN
NC
RANCH
12
ENGLEWOOD
13
Rd
ker
Par
LITTLETON
ET
10
225
25
University Blvd
285
Broadway
Kipling Pkwy
Sheridan Blvd
LAKEWOOD
70
The Children’s Hospital at
Saint Joseph Hospital, Denver
12
COLORADO
SPRINGS
13
14
PARKER
PUEBLO
15
14
15
Memorial Hospital for Children,
Colo. Springs
The Children’s Hospital Center for Cancer
and Blood Disorders, Colo. Springs
The Children’s Hospital Therapy Center,
Pueblo
tch10062009
Pediatric Emergency or Urgent Care offered at these locations.
For a complete list of services offered, please see reverse.
2006-2008 Departmental Report
11
departmental mission summary
research
summary
Department of Pediatrics’ faculty members conduct cutting-edge research across the entire
breadth of pediatrics. The goal of this research is to improve the health of children in our
region and make major impacts across the state, nation, and world.
T
he move of The Children’s Hospital in September
grant programs and infrastructure for translational
2007 to Fitzsimons and the subsequent relocation of
research. Of particular importance to pediatrics is the
the clinical and research faculty to the Anschutz Medical
fact that one of the six “pillar programs” in this new
Campus have transformed the academic environment
institute will focus on expanding translational research
of the Department. The campus includes new, state-of-
in Child and Maternal Health.
the-art research laboratories and educational facilities
The synergism generated by the new combined cam-
that encourage new collaborations and interdisciplinary
pus can be seen in the expansion of the regenerative
research teams. This rebuilding, relocation, and juxtapo-
medicine and developmental biology programs in both
sition of resources is unparalleled in medical centers in
adult and pediatric research. The Children’s Hospital
the U.S. These new facilities create opportunities for the
(TCH) announced in November 2007 the receipt of
Department of Pediatrics to expand on its national repu-
a $5 million gift from the Gates Frontiers Fund that
tation as one of the top 10 academic pediatric depart-
will allow the Charles C. Gates Chair of Regenerative
ments in the nation.
Medicine and Stem Cell Biology Program at the UCD
Over the past five years, the combined funding
School of Medicine toВ expand its research program to
(including pediatric faculty based at our affiliated hos-
encompass pediatrics. The School of Medicine recruited
pitals) for clinical and basic research has increased from
Dr. Dennis Roop from Baylor to lead the adult pro-
$60 million in 2002 to $89 million in 2008. We are
gram, while the Department of Pediatrics recruited
ranked first among all medical school-based depart-
Dr. Bruce Appel from Vanderbilt to lead its program;
ments of pediatrics in National Institutes of Health
Dr. Appel holds the Diane G. Wallach Chair in
(NIH) research funding. This increase occurred over a
Pediatric Stem Cell Biology.
time period when federal funding had been relatively
In 2008, TCH and UCD finished a six-month
flat. In addition, the faculty in our department (and
strategic planning process specific to child health
affiliates) has eight active NIH training grants (T32) that
research. The plan determines where to make future
support the development of new academic faculty.
investments in emerging science and research, new
In May 2008, the University of Colorado Denver
laboratory and ancillary space, and training for
(UCD) received an NIH Institutional Clinical and
tomorrow’s scientists. This plan will maintain and
Translational Science Award. This award provides
expand our cutting-edge research programs and
umbrella funding for the newly transformed Children’s
develop new research opportunities.
Hospital and University of Colorado Hospital Clinical
The Department of Pediatrics will be a significant
and Translational Research Centers, formerly the
contributor to the new National Children’s Study.
Pediatric and Adult General Clinical Research Centers.
A recent Health and Human Services award to the
It includes additional funding for a mentored young
Colorado School of Public Health will allow for the
investigator training program (K12) and a predoctoral
creation of a large database that will track 2,000 normal
training program (T32), and it funds substantial pilot
children in the Denver area, preconception through age
21, working closely with the Department of Pediatrics.
12 D e p a r t m e n t o f P e d i a t r i c s
research summary
Anschutz Medical Campus, Research Complex
Courtyard between Research Complex Buildings I
and II on Anschutz Medical Campus
This nationwide study of 100,000 children will collect
new ideas. The TCHRI sponsors new research initiatives
environmental and family data.
in all disciplines found at Children’s (including nursing
Department of Pediatrics faculty members continue
to make broad impacts on science and medicine at
and pathology) and also houses:
Clinical Trials Organization: Supports TCH faculty
n
UCD. Robin Shandas, PhD, heads up a new Center
and staff who are involved in clinical trials evaluat-
for Bioengineering. This new research and educational
ing state-of-the-art drugs and devices for treating and
program is targeted to become a department within the
preventing childhood diseases.
School of Medicine with its own research and degree-
Children’s Outcomes Research Program (COR):
n
granting program. Kurt R. Stenmark, MD, has taken
In association with the Colorado Health Outcomes
the leadership role for the Cardiovascular Pulmonary
Program (COHO), COR fosters major community
Research Program as it expands and identifies new ave-
translational research efforts in pediatrics. COR is
nues of research to treat young heart and lung patients.
known nationally for health services research in the
provision of preventive pediatric care and also pro-
Research Infrastructure in the Department of Pediatrics
vides methodological and analytical support for many
The Children’s Hospital Research Institute—As the
pediatric faculty engaged in other areas of community
umbrella organization for all research at Children’s,
translational research. Currently, COR is collaborat-
The Children’s Hospital Research Institute (TCHRI),
ing with COHO on community initiatives that extend
established in 1992, provides resources, oversight,
over the lifespan, including projects targeting preven-
funding, and expertise to new research programs at
tion of obesity, cardiovascular disease, and diabetes,
TCH and is funded in large part by the generosity of
and practice reorganization to improve quality of
community philanthropy. Support is directed toward
preventive health care delivery.
funding promising pediatric scientists and pioneering
2006-2008 Departmental Report
13
research summary
Experimental Therapeutics Program (ETP): The goal
As part of the CTSA grant, the former Adult General
n
of the ETP within the Center for Cancer and Blood
Clinical Research Center (GCRC) at University of
Disorders is to promote the development, scientific
Colorado Hospital and the Pediatric GCRC at TCH –
support, and clinical translation of promising thera-
which were already being supported by the NIH –
pies for the treatment of children, adolescents, and
are now part of the Institute and have been transformed
young adults with cancer and related disorders. The
into a new network of Clinical Translational Research
ETP at Children’s is the only comprehensive basic
Centers (CTRCs). The TCH CTRC supports more than
and translational research-based program that can
provide direct access to and application of these
resources to the clinical care of pediatric, adolescent,
Total Research Revenue FY2004–FY2008 (In Millions)
Total (Direct and Indirect) Expenditures
and young adult cancer patients in an eleven-state
region. Because of strong academic affiliations locally
$89.1
$88.2
$90
and nationally, the ETP at Children’s can provide
access to new treatments and treatment modalities
$80.3
$80
only available at a few highly select academic
institutions across the country.
Biostatistical Support: Biostatistical collaboration
$72.8
$70
$69.4
n
is available to researchers to help them mine and
analyze data; this is especially helpful to researchers
$60
with pilot studies.
Bioinformatics Support: Database support is provided
n
$50
to help researchers manage complex datasets and
biological information.
$40
Colorado Clinical and Translational Sciences Institute
The new Colorado Clinical and Translational Sciences
$30
Institute (CCTSI) has been established with a $76 million Clinical and Translational Science Award (CTSA)
$20
from the NIH. The institute brings together health organizations across Colorado by providing an academic
$10
home to clinical and translational research, including
the more than 160 current clinical research studies of
childhood diseases.
The CCTSI encourages and facilitates research and
provides support through six major programs: Discovery
0
2004
2005
2006
2007
National Jewish Health
Barbara Davis Center for Childhood Diabetes—Pediatric Faculty
Translation; Community Translation; Education,
The Children’s Hospital Research Institute
Training, and Career Development; Translational
Pediatric Clinical Translational Research Center
Informatics; Novel Methods and Technologies; and
Human Medical Genetics
Child and Maternal Health Research.
Department of Pediatrics
14 D e p a r t m e n t o f P e d i a t r i c s
2008
research summary
160 active research protocols and 185 principal inves-
n
tigators, representing all of the major areas of pediatric
n
medicine. It provides inpatient, outpatient, research
n
Lactation Program
Intrauterine Growth Restriction
Zinc Requirements for Growth; Diagnosis and
nursing, laboratory, and funding support for clinical-
Treatment of Childhood Obesity
translational research for faculty and trainees in many
n
departments. Over the years, the Pediatric GCRC pro-
n
Phase III Children’s Oncology Clinical Trials
Liver: Acute Liver Failure, Transplantation, and
vided several cores that have proven extremely helpful
for young investigators, including the Core Laboratory,
Inflammatory/Immune Diseases
Prevention/Treatment of Type 1 Diabetes; Causes of
n
Molecular and DNA Diagnostic Lab, Bionutrition,
Biostatistics, Bioinformatics, Scientific Review, and
Type 2 Diabetes
Transfusion-Related Acute Lung Injury; Bleeding and
n
Research Subject Advocacy; and all of these cores are
being fully integrated into the new CCTSI.
Clotting Disorders
Maternal Obesity and Diabetes Effects on Neonatal
n
Insulin Resistance and Body Composition
Research Programs
Pathophysiology, Genetics, and Treatment of
n
Specific child and maternal health research programs
Metabolic Diseases
within the Department of Pediatrics include, but are not
n
limited to:
n
Preventive Health Care for Children; Immunizations
Domestic Violence
Developmental Biology and Stem Cell Program
n
Children’s Hospital Immuno-Deficiency Program
n
n
n
Statewide Newborn Screening
Home Visitation, Obesity in Children of Mexican
(CHIP)
Immigrants; Reduction of High-Risk Deliveries in
Intellectual and Developmental Disabilities Research
Rural Settings; Emotional Regulation in High-Risk
n
Center (IDDRC)
Pediatric Heart Lung Center
n
Infants; Mother-Infant Interactions
Childbearing, Care During Labor, Outcomes, Healthy
n
Cystic Fibrosis Research Program
Nulliparous Women
n
Eosinophilic Gastrointestinal Diseases Research
n
Great Vessel Blood Flow and Vascular Remodeling;
n
Program
Mechanical Properties of the Umbilical Cord and
Placental Development and Function; Fetal Growth
Pregnancy Outcome; Nanotechnology in MRI
n
and Development
Biliary Atresia Research Consortium and Cholestatic
n
Detection of Tumors
Contraceptive Behaviors in the Native American
n
Liver Disease Consortium
Neonatal Nutrition
n
Population
Role of Complement in Genesis of Preeclampsia
n
Neonatal Persistent Pulmonary Hypertension – Nitric
n
Oxide Treatment; Bronchopulmonary Dysplasia
Pediatric Oncology Experimental Therapeutics
n
Consortium
Newborn Screening in Cystic Fibrosis, Gene
n
Modifiers, Biomarkers of Lung Disease
Pulmonary Hypertension and Vascular Development
n
Our new facilities, talented leadership, increased funding, and new programs are working together to ensure
the Department of Pediatrics continues to make discoveries that will improve children’s health and will train
the future pediatric investigators who will discover
tomorrow’s treatments and cures.
2006-2008 Departmental Report
15
departmental mission summary
education
summary
The Department of Pediatrics is involved in multiple educational programs serving medical
students, physician assistants, residents, fellows, and faculty (both full-time and volunteer
clinical faculty). Active programs and faculty who direct major educational initiatives are
summarized here.
Medical Student Experiences
viduals receive extensive pediatric training, and CHA/
There are currently 156 students per class at the
PA graduates work in hospital and community sites
University of Colorado Denver School of Medicine
throughout the country. In the past 10 years, the pro-
(UCDSOM). The University recently initiated a com-
gram has brought in approximately $4 million in HRSA
prehensive revision of the Medical School curriculum in
(Health Resources and Services Administration) training
order to integrate clinical and basic science experiences.
grants and CCHE (Colorado Commission on Higher
This effort was led by Dr. Robin Deterding, Associate
Education) award money to support education.
Dean for Clinical Curriculum, and Dr. Bruce Wallace,
Assistant Dean for Essentials Core Curriculum. All
Pediatric Residency Experiences
third-year students complete a six-week experience in
The Pediatric Residency Program currently trains 82
the Infant, Child and Adolescent Care Clerkship, involv-
pediatric residents, has 3 Chief Residents, and is directed
ing both inpatient, outpatient, and nursery experiences
by Drs. Adam Rosenberg, Marsha Anderson, and Carol
at TCH and other affiliated facilities, as well as office-
Okada. The program provides comprehensive clinical
based experiences with our volunteer clinical faculty.
training in all aspects of pediatric medicine and prepares
Dr. Jennifer Soep is the Clerkship Director for Infant,
residents for careers in primary care pediatrics or in
Child and Adolescent Care and Dr. Julie Noffsinger is
subspecialty academic pediatrics. More than 1,000 U.S.
the Assistant Clerkship Director.
senior medical students apply to our Residency Program
Dr. Shale Wong is the Director of Medical Student
yearly. Rotations occur at The Children’s Hospital,
Education and oversees subinternships, externships,
University of Colorado Hospital, and Denver Health.
specialty electives, and research opportunities for
Continuity clinics take place at multiple locations, includ-
students. She recently assumed directorship of the
ing community-based pediatric offices and community
Mentored Scholarly Activity Program wherein all
health centers. The curriculum also includes formal train-
UCD medical students are required to complete a
ing in medical Spanish, joint faculty/resident international
scholarly project during their four years of medical
rotations, rural rotations, and opportunities for resident
school. Dr. Wong works with pediatric faculty to
research. A mandatory 1-month rural rotation is offered
organize projects and mentoring for those medical
at multiple locations throughout Colorado including
students interested in pediatrics.
Estes Park, Loveland, Glenwood Springs, Grand Junction,
Alamosa, Fort Collins, and Aspen.
Child Health Associate/Physician Assistant Program
The CHA/PA Program is directed by Anita Glicken,
Subspecialty Fellowship Training
MSW, and it is administratively located within the
A Committee on Fellowship Education (C.O.F.E.)
Department of Pediatrics. The program was established
meets regularly to provide a centralized curriculum
in 1969 and currently graduates 40 students each year
for the 80 pediatric fellows training in our program.
who have completed a three-year program leading to
Members of the committee include Mary GlodГ©, MD,
board certification as a physician assistant. These indi-
Thomas Parker, MD, Genie Roosevelt, MD, MPH,
16 D e p a r t m e n t o f P e d i a t r i c s
education summary
Michael Narkewicz, MD, Timothy Garrington, MD,
Eva Gracyk, MD, and Stephen Daniels, MD, PhD.
Additional educational experiences are provided by the
individual Sections within the Department of Pediatrics
and also include graduate-level courses in the Clinical
Sciences Program at UCD.
More than 30 hours of formal interactive sessions
are held yearly for all first-year fellows to cover their
core curriculum, including teaching, professionalism,
evidence-based medicine, ethics, cultural competency,
giving and receiving feedback, searching the literature,
and basic biostatistics. An additional, more comprehensive seven-week course in biostatistics is offered to second- and third-year fellows, as well as yearly retreats
for each group of fellows.
Medical Education Front row, l - r: Linda Swinburn, Shaun Ayon,
Andrea Reed; Middle row, l - r: Eric Sommers, Brenda Cordova, Jennifer
Kupfer, Shale Wong, Kathy Morten; Back row, l - r: Mary GlodГ©, Adam
Rosenberg, Theodore Laetsch, Colleen Muzynoski
(Leadership, Education, Advocacy, Development,
Scholarship). This training program receives fund-
Faculty Development
ing from multiple sources, locally from the Colorado
Faculty development seminars have been held for
Health Foundation and federally from HRSA. Drs. Steve
volunteer clinical faculty and for full-time faculty, led
Federico and Steve Berman have been instrumental in
by Drs. Carol Kamin, Shale Wong, and Jennifer Soep.
the scholarly development and implementation of this
A Clinical Faculty Affairs Committee, coordinated by
advocacy program. Research involving the use of stan-
Karen Leamer, MD, and Bobbi Siegel, MSW, is very
dardized patients to evaluate the impact of a communi-
active and provides input to the Department regarding a
cation curriculum is also ongoing, as is research study-
number of issues related to community-based clinical fac-
ing the effect of a structured curriculum for hematology/
ulty affairs. Specific seminars on mentoring have received
oncology fellows on delivering bad news to families.
attention in the past year, and plans are being made for
Dr. Deterding and colleagues have received an
the development of a Center for Clinical Learning and
IMPACT (Improving Pediatric Asthma Care Training)
Teaching within the Medical Education Department.
Grant. They are applying concepts adapted from Project
L.I.V.E. to continuing medical education. This grant
Educational Research
provides case simulation coupled with office tools to
The Department of Pediatrics has developed a number
support patient education in asthma, with the goal of
of major educational innovations that have been dis-
improving asthma care throughout the state. It com-
seminated nationally. Drs. Carol Kamin and Robin
bines evidence-based approaches to improve changing
Deterding, along with other colleagues, developed
physician behavior, and it researches how this approach
an online, interactive, case-based video learning sys-
works in continuing medical education.
tem for medical students, entitled Project L.I.V.E.
Numerous pediatric faculty have completed the
(Learning through Interactive Video Education). This
UCDSOM Teaching Scholars Program, and four pediatric
work received the UCD President’s Faculty Excellence
faculty members were recently selected for the 2009
Award for Advancing Teaching and Learning through
program: Drs. Jennifer Soep, Julie Parsons, Amy Sass,
Technology. Dr. Shale Wong co-directs a leadership and
and James Barry. The Teaching Scholars Program is an
advocacy track within the medical school, CU-LEADS
18-month program consisting of medical education
2006-2008 Departmental Report
17
education summary
seminars focused on teaching and learning in medicine
by the community providers. Full-time faculty members
and evaluating quality and outcomes in medical education.
along with national guest lecturers speak at this pro-
Scholars are selected for their role or potential in providing
gram and a panel discussion with community-based
leadership to the educational programs in their departments.
providers is an integral part of the evening.
The Department of Medical Education has a Pediatric
Multiple other faculty in the Department of Pediatrics
Education Group that meets weekly to work on a vari-
are also involved in directing specific courses for medical
ety of projects related to the future of pediatric training.
students, physician assistants, residents, fellows, and fac-
Members of the group include M. Douglas Jones, Jr.,
ulty. In addition, many other faculty and staff serve on
MD (Chair of the Board of Directors of the American
committees that support work in medical education.
Board of Pediatrics and former Chair of the Department
The Department of Pediatrics is highly devoted to
of Pediatrics, UCDSOM), Drs. Adam Rosenberg, Carol
medical education at every level of training. With a
Okada, Marsha Anderson, Jennifer Soep, Shale Wong,
commitment to innovation and excellence, the medical
Mimi GlodГ©, Amy Sass, and Julie Noffsinger, and Anita
education team strives to develop, implement, and evalu-
Glicken, MSW, Eric Sommers, and Bobbi Siegel, MSW.
ate educational programs that result in outstanding pedi-
This group is currently involved in evaluating residency
atric health care providers for Colorado and the nation.
training in pediatrics through formal focus group visits
with practices around the State of Colorado. In addition, the group is working to enhance pediatric training
of medical students and residents by identifying additional training sites in the community and providing
faculty development to these groups to increase teaching
effectiveness and efficiency.
The Chairman of the Department meets monthly
with the Vice Chair of Education and representative
educators from the School of Medicine, the CHA/PA
Program, and residency and fellowship programs to
discuss best practices, models, and innovation in education and to chart our goals and direction.
Continuing Medical Education
The Continuing Medical Education Program has a new
Medical Director, Amy Sass, MD, and a Manager,
Shaun Ayon. In 2008, The Children’s Hospital provided
approximately 46 CME activities with 640 hours of
instruction for 4,500 MDs and more than 10,000 nonphysician participants. The Department of Pediatrics
has developed a program called Pediatric Challenges in
conjunction with the Clinical Faculty Affairs Committee.
Pediatric Challenges is held 4 to 5 times per year and is
an evening series for community providers that attracts
80 to 100 participants and covers clinical topics requested
18 D e p a r t m e n t o f P e d i a t r i c s
Medical Education Faculty
Mary P. GlodГ©, MD**
Professor of Pediatrics
Vice Chair, Education
Section Head, Infectious Diseases
Carol R. Okada, MD***
Instructor of Pediatrics
Associate Program Director,
Pediatric Residency Program
Marsha S. Anderson, MD*
Associate Professor of Pediatrics
Associate Program Director,
Pediatric Residency Program
Adam A. Rosenberg, MD*
Professor of Pediatrics
Director, Pediatric Residency
Program
Robin R. Deterding, MD*
Professor of Pediatrics
Associate Dean, Clinical Curriculum,
School of Medicine
Director, Breathing Center
Director, Children’s Interstitial Lung
Disease (ChILD) Program
Jennifer B. Soep, MD**
Assistant Professor of Pediatrics
Director, Clinical Clerkship in Infant,
Child and Adolescent Care
Jacqueline J. Glover, PhD
Associate Professor of Pediatrics
Associate Professor of Community
and Behavioral Health, Colorado
School of Public Health
Center for Bioethics and Humanities,
University of Colorado Denver
Co-Director, Program in Bioethics,
The Children’s Hospital
Carol Kamin, EdD, MS
Associate Professor of Pediatrics
Director, Medical Education,
Research and Development
Director, Project L.I.V.E.
Julie Noffsinger, MD*
Assistant Professor of Pediatrics
Assistant Director, Clinical Clerkship
in Infant, Child and Adolescent
Care
Shale L. Wong, MD, MSPH*
Associate Professor of Pediatrics
Director, Medical Student Education
Director, Mentored Scholarship
Co-Director, LEADS
* Infectious Diseases Faculty
* Pulmonology Faculty
* General Academic Pediatrics
Faculty
* Neonatology Faculty
* Epidemiology Faculty
* Pediatric Hospital Medicine
Faculty
**Denver Health Faculty
**Allergy, Immunology and
Rheumatology Faculty
departmental mission summary
advocacy
summary
Advocating for children everywhere is a top priority for The Children’s Hospital (TCH) and the
Department of Pediatrics at the University of Colorado Denver School of Medicine (UCDSOM).
A key component of the mission is to “enhance the health and well-being of the children
and families in our community.” To this end, Department of Pediatrics’ faculty and trainees
actively collaborate with the Department of Public Affairs at Children’s and colleagues at
UCDSOM, the Colorado School of Public Health, and the Colorado Chapter of the American
Academy of Pediatrics to effect comprehensive and strategic advocacy and legislative efforts
on the local, state, and national levels.
D
epartment of Pediatrics’ faculty members have been
support to Denver Health, the preeminent community
leaders in child advocacy in Colorado, nationally,
health clinic system in the nation.
and internationally. The State of Colorado has had more
Department of Pediatrics’ faculty have played an
presidents of the American Academy of Pediatrics than
ongoing role in community organizations advocat-
any other state, including Franklin Gengenbach, MD,
ing for improved health care for children, including
James Strain, MD, Donald Schiff, MD, Donald Cook,
the “2010 All Children Covered” initiative of the
MD, and Stephen Berman, MD. With their leadership,
Colorado Coalition for the Medically Underserved, the
the American Academy of Pediatrics has led the nation
Colorado Children’s Campaign, the Colorado Children’s
in advocacy for universal health coverage for children
Immunization Coalition, Bright Beginnings, and many
and the development of the Medical Home Initiative,
others. By assuming leadership roles in these various
which is now recognized as the foundation for creating
organizations, faculty members have had the opportu-
a better health care system to improve the health out-
nity to work with community advocates and institute
comes of children and adults.
meaningful state-level change for children’s health care.
Department of Pediatrics’ faculty members – working
In addition, the faculty of the Department of
with the Department of Public Affairs at TCH – have
Pediatrics has played a leading role in providing and
taken leading roles in implementing these initiatives
improving the clinical care of and advocacy for chil-
in Colorado, chairing and participating in community
dren with specific diseases on a local and national level,
efforts to successfully write, pass, and implement leg-
including children with special health care needs, epider-
islation to create the State Child Health Plan (SCHIP);
molysis bullosa, cystic fibrosis, sickle cell anemia, HIV,
expand Medicaid eligibility and benefits; improve health
vaccine-preventable diseases, and childhood obesity.
plan benefit coverage for children with congenital condi-
Notably, C. Henry Kempe, MD, a mentor to many and
tions; create better child restraint requirements; simplify
past Chairman of the Department, first described and
the Medicaid enrollment process for families; measure
then led the nation in recognition of child abuse and
population-based child health outcomes; and implement
neglect, publishing the landmark paper “The Battered
the medical home concept for all children in Colorado.
Child Syndrome” and founding our affiliated Kempe
One example is the creation of the Colorado Children’s
Center for the Prevention and Treatment of Child Abuse
Healthcare Access Program (CCHAP), a collaborative
and Neglect. The Kempe Center continues to lead the
effort of the Department, TCH, and community founda-
national effort to prevent child abuse.
tions to provide the systems and resources to support
The Department of Pediatrics has also formalized its
community physicians in the provision of medical homes
ongoing commitment to advocacy by providing educa-
for all children in Colorado. In addition, our affiliated
tional opportunities to develop the child health advocates
faculty, residents, and students provide core pediatric
of the future. A legislative advocacy elective has been
2006-2008 Departmental Report
19
advocacy summary
designed for pediatric residents to provide an overview
of TCH’s legislative advocacy efforts on behalf of children. Elective participants gain an understanding of the
legislative process and the variety and scope of legislative
issues introduced each year that have the potential to
impact the health and well-being of Colorado’s children;
and they are able to learn how physicians and advocates
can influence public policy decisions related to children’s
health and the provision of pediatric health care. Our
faculty also has been instrumental in developing an interdisciplinary elective on leadership and advocacy. Initially
designed for medical students, the Leadership Education
Advocacy Development and Scholarship (LEADS)
curriculum has been adapted for resident use as well.
Leaders in Child Advocacy l-r: Stephen Berman, MD, Amy Shiver, MD,
James Todd, MD, Steven Poole, MD
The premise is to teach young physicians the skill set
gual residents and the interpreter services at TCH. The
that will empower them as physician advocates.
course is designed to help all residents develop basic language skills, become more culturally aware, and become
“In addition, we have instituted a diversity and
skilled in using interpreter services.
cross-cultural training program for residents and
faculty, spearheaded by Dr. Steven Poole, which creates
Because it is also important to understand the different
health care needs of both rural and urban populations,
a learning community to enable faculty and residents
pediatric residents spend one month
to improve skills in caring for
outside of the Denver metropolitan
minority and low-income children,”
said James Todd, MD, Vice Chair of
Advocacy, Department of Pediatrics.
The Department of Pediatrics and
TCH also offer international advo-
“We have instituted a diversity and
cross-cultural training program for
in the needs of different cultures.
Because we believe that international
experiences are extremely valuable
out Colorado, including Durango,
Estes Park, Grand Junction, and
learning community to enable faculty
popular rotation in the program and
Glenwood Springs. This is a very
offers our residents an opportunity
health care provision outside of the
U.S., which provide understanding
pediatricians at locations through-
residents and faculty, which creates a
cacy opportunities. Many residents
are interested in opportunities and
area working with community-based
and residents to improve skills in caring
for minority and low-income children,”
—James Todd, MD
to see medical care from the point of
view of the rural-based pediatrician
and patient.
Advocacy for improving the
to professional training, we offer
health status of children will con-
residents the International Child
tinue to be a critical aspect of the
Health Elective, a one-month elective rotation in Peru,
mission of the Department of Pediatrics at UCDSOM.
Ecuador, or Guatemala. We also have developed a 7- to
Our long tradition in this area provides the platform for
10-week course in medical Spanish that is run by bilin-
the advocacy efforts of the future.
20 D e p a r t m e n t o f P e d i a t r i c s
departmental mission summary
international
summary
International activities have been a long-standing component of the Department of
Pediatrics. For years our faculty and residents have traveled and worked in many parts
of the world. Over the last few years, however, the department has established more
formal relationships with programs abroad.
T
en years ago a group of faculty created the
International Child Health Elective.* The initial
location for this program was in Latin America. The
first group went to Lima, Peru, and rotated through
the Hospital de NiГ±os and Hospital Nacional Cayetano
Heredia. Our residents continue to go to Lima: recently,
two residents spent a month at the Hospital Regional
in Cuzco, Peru; and another resident went to rural Peru
and worked in a small clinic for a month.
In 2004 the program expanded to Guatemala at
the Roosevelt Hospital in Guatemala City. In 2006 an
exchange program was established with the Baca-Ortiz
Children’s Hospital in Quito, Ecuador. Two groups
of residents went to Quito and one group of three
Ecuadorian residents spent a month here in Colorado.
Residents Katie McPeak, MD (left) and Christopher Baker, MD (right)
with Guatemalan mother and son
To date, The Department of Pediatrics has now estab-
Academy of Pediatrics and have traveled internationally
lished formal agreements with these training programs.
to volunteer their services, as have Susan Niermeyer,
The Department honors requests from these countries
MD, who has also taught a neonatal resuscitation
to have their residents come to our pediatric residency
course, and Stephen Berman, MD, who has spearheaded
training program at the University of Colorado Denver
natural disaster training programs.
(UCD). As a result of these exchanges, four individuals
Jacinto HernГЎndez, MD, MHA, a renowned Peruvian
from Peru and one individual from Ecuador have been
neonatologist on our faculty, has traveled frequently to
accepted into the resident training program.
Peru to teach and has been instrumental in establishing
In addition to the more formal arrangements in Latin
America, pediatric residents have taken electives in
the international elective program.
Faculty from the Departments of Otolaryngology and
Cambodia, Zimbabwe, and Chile. And most recently,
Cardiac Surgery have contributed time abroad, in addi-
three residents went to Cambodia, one of whom com-
tion to other Department of Pediatrics’ faculty. Edward
pleted a project in hematology at a local hospital there.
Goldson, MD, serves as coordinator for the internation-
While the pediatric residents have been active, so
al rotation, primarily in Peru, Guatemala, and Ecuador.
have the full-time and clinical faculty at UCD. Nancy
Dr. Goldson has traveled to these countries for the past
Krebs, MD, and Steven Federico, MD, have been
25 years, where he has made rounds and given lectures.
involved with training programs for the American
He also coordinates international visitors with rotations
in the Department as part of the exchange program
2006-2008 Departmental Report
21
international summary
with Peru, Guatemala, and Ecuador. In addition, Dr.
Goldson has been invited to lecture abroad independently of the program in Peru and Ecuador, and he has done
volunteer work in Ecuador along with Dr. James Shira.
A number of other Department faculty have participated in providing care in Latin America, India, Asia,
and Africa, including Keren Call, MD, who has done
volunteer work in northern Peru; Norman Scott, MD,
who has volunteered all over the world for Operation
Smile; Ann-Christine Nyquist, MD, MSPH, and Lou
Hampers, MD, MBA, who have both volunteered
in Africa. Taru Hays, MD, has worked as a Visiting
Professor in Ecuador, teaching medical students,
pediatric residents, and nurses in clinical pediatrics.
Dr. Hays was also among the faculty accompanying
pediatric residents to Lima, Peru, Quito, Ecuador, and
Guatemala City, Guatemala, teaching clinical pediatrics
Edward Goldson, MD, serves as coordinator for the International Child
Health Elective
The Department’s international relationships continue
and pediatric hematology. Also Eric SimГµes, MB, BS,
to grow. These efforts are enhancing our Department’s
DCH, MD, has worked a great deal internationally,
mission to expose our trainees to different cultures in an
including extensive consulting to the World Health
effort to expand their cultural proficiency.
Organization and research in Indonesia, the Philippines,
Denmark, and Europe. These have been rich experiences
*Federico SG, Zachar PA, Oravec CM, Mandler T,
for our faculty and residents as well as for the communi-
Goldson E, Brown J. A successful international child
ties to which they have contributed.
health elective: the University of Colorado Department
of Pediatrics’ experience. Arch Pediatr Adolesc Med.
2006 Feb;160(2):191-6. [PMID: 16461877]
Residents Emily Kevlan, MD, and Amy Shriver, MD, with Edward Goldson, MD,
(middle), in front the of the Hospital Nacional Cayetano Heredia
22 D e p a r t m e n t o f P e d i a t r i c s
Amy Shriver, MD, with Peruvian medical students at the Nacional Hospital
Cayetano Heredia
2 0 0 6 – 2 0 0 8 DE PA R T M E N T F E AT U R E
the largest research grant
in Colorado’s history
Colorado Clinical and Translational
Sciences Institute
A
n NIH research grant to the University of Colorado Denver has
resulted in a new institute for clinical and translational research
studies, including the more than 160 current clinical research studies
for childhood diseases. The $76 million Clinical and Translational
Science Award (CTSA) from the NIH was awarded in May 2008
and is the largest research grant in the State of Colorado’s history.
The grant has funded the creation of the Colorado Clinical and
Translational Sciences Institute (CCTSI), with the goal of improving
the health of the people in Colorado.
The CCTSI is an “institute without walls” that brings together a
number of partnering organizations, including University of Colorado
Denver, University of Colorado at Boulder, The Children’s Hospital,
University of Colorado Hospital, Denver Health, National Jewish
Health, VA Medical Center in Denver, and Kaiser Permanente, in
addition to 20 community organizations and research groups. The
CCTSI also brings many ongoing programs together in a new integrated and coordinated effort that will make it easier for investigators
to find collaborators and for those outside of the University and in the
private sector to communicate and collaborate with our researchers.
“The CCTSI has a very wide breadth,” said Ronald J. Sokol, MD,
Director and Principal Investigator of the CCTSI, and Professor and
Vice Chair, Clinical and Translational Research, Department of Pediatrics, University
Ronald Sokol, MD, Director and
Principal Investigator, Colorado
Clinical and Translational
Sciences Institute
of Colorado Denver School of Medicine. “It really is a state resource as well as a
University resource. This grant funds our institution to develop a true academic home
for clinical and translational research and training with the goal of speeding discoveries into clinical practice – from our labs to your lives.”
Translational research bridges the gap between basic science and clinical med-
icine and brings new advances into practice, to the bedside, and to the community.
According to Dr. Sokol, the goal of the CCTSI is to improve health care in Colorado
by transforming “how we currently perform and train investigator teams in clinical
and translational research.”
2006-2008 Departmental Report
23
CCTSI
“The uniqueness of this institute and the value to everyone is that we don’t choose
researchers based on the diseases they study,” Dr. Sokol added. “It’s based on the
quality of science and what is needed to improve health in the State of Colorado,
including the needs of children.”
The Institute encourages and facilitates research and provides support through six
major programs:
Discovery Translation. Bench-to-bedside research that brings discoveries from
n
the laboratory into clinical testing. This includes developing new interdisciplinary
teams of investigators that will approach medical problems from new angles and
“The uniqueness of this
with new ideas. It also includes taking a clinical observation back into the laborainstitute and the value to
tory and developing a cellular or animal model to better study the disease. In addition, biostatistical collaboration and regulatory knowledge support resources are
everyone is that we don’t
choose researchers based
included in this program.
Community Translation. The research of taking the discovery of a new treatment,
n
intervention or prevention, applying it in the community, and looking at a community setting to determine if it has improved health and resulted in better, cost-
on the diseases they study.
effective access to care. “One of the emphases of the CCTSI is to engage the comIt’s based on the quality of
science and what is needed
munities around the state to become involved in research and address issues that
are important to them,” Dr. Sokol said.
Education, Training, and Career Development. Provides leadership, mentoring, and
n
to improve health in the
didactic training and other career development opportunities, including offering
State of Colorado, including
ing program (K12), and a pre-doctoral training program (T32) to teach PhDs about
PhD and Master’s degrees in clinical sciences, a mentored young investigator traintranslating basic discoveries into the clinical setting. “The CCTSI will ensure that
the needs of children.”
the pipeline of new investigators is robust, that young people become interested in
clinical research, obtain the right training to become experts in conducting clinical
—Ron Sokol, MD
and translational research, and that they get assistance and mentoring to launch
their careers,” Dr. Sokol said.
Translational Informatics. This program focuses on applying emerging computer
n
technologies to research, electronic data capture and management, using electronic
medical records for research and data analysis.
Novel Methods and Technologies. Provides investigators with new biomedical tech-
n
nologies to facilitate research, including genomics, genetics, and imaging facilities.
The program will provide $700,000 in pilot grant awards per year for investigators
and fosters development of new methods to promote research.
24 D e p a r t m e n t o f P e d i a t r i c s
CCTSI
Child and Maternal Health Research. As part of the CTSA grant, the former Adult
n
General Clinical Research Center (GCRC) at University of Colorado Hospital
and the Pediatric GCRC at The Children’s Hospital – which were already being
supported by the NIH – are now part of the Institute and have been transformed
into a new network of Clinical Translational Research Centers (CTRCs). This network also includes CTRCs at National Jewish Health, University of Colorado at
Boulder, and Denver Health. The CTRCs provide research nursing, inpatient and
outpatient facilities for researchers to conduct clinical and translational research,
as well as assurances for research participant safety. “The Child and Maternal
At The Children’s Hospital
Health program’s goal is to enhance the emphasis on “life cycle research” on the
Anschutz Medical Campus, including pediatric, child health, neonatal, and pregnancy research. By having a special program that focuses in these areas, including
a multidisciplinary steering committee, it will help investigators perform research
that will look at the life-long effects of the health of a child while in the womb,
as newborns, and as older children, as well as influences of the health of pregnant
women.” Dr. Sokol said. “The goal is to integrate child health research into all the
CTRC, numerous studies
in the past 20 years have
made a significant impact
on children’s health. For
other CCTSI programs across the campus.”
example, many of these
In addition to Dr. Sokol heading up the CCTSI and serving as principal investigator,
two of the six CCTSI Co-Directors are Department of Pediatrics’ faculty based at
Children’s: William Hay, Jr., MD, is Director of Child and Maternal Health Research;
and Michael Kahn, MD, PhD, is Director of Translational Informatics.
At The Children’s Hospital CTRC (formerly the Pediatric GCRC), numerous
studies have tested new
treatments to improve lung
function in patients with
studies in the past 20 years have made a significant impact on children’s health. For
example, many of these studies have tested new treatments to improve lung function
cystic fibrosis (CF).
in patients with cystic fibrosis (CF).
“Many new treatments have been tested here at Children’s and at other sites, such
that the average life span for CF is now well into adulthood,” Dr. Sokol said. “There
are tangible benefits from much of the research that has been done and new treatments that have been implemented. This is exactly the type of work the CCTSI will
enhance and support.”
The CTSA is a five-year grant, which Dr. Sokol envisions hopefully will be renewed
“many years over.”
“The GCRC program that the CTSA replaces has been funded for 45 years,”
Dr. Sokol said. “The NIH transformed the old GCRC and some other programs
into the new CTSA program in order to speed discoveries to the patient.”
For more information, please visit http://ctsa1.uchsc.edu.
2006-2008 Departmental Report
25
DE PA R T M E N T F E AT U R E 2 0 0 6 – 2 0 0 8
local access to comprehensive
multidisciplinary care
Gastrointestinal Eosinophil Diseases Program
U
ntil recently, children with Eosinophilic Gastrointestinal Diseases (EGIDs) who
lived in the Rocky Mountain Region did not have local access to comprehensive
multidisciplinary care. To fill this void, the Gastrointestinal Eosinophil Diseases
Program (GEDP), a collaborative program between The Children’s Hospital, the
Section of Gastroenterology, Hepatology and Nutrition in the Department of
Pediatrics, and National Jewish Health, was developed by Glenn T. Furuta, MD, and
F. Dan Atkins, MD. Launched in December 2007, the GEDP has already provided
care for more than 250 patients from more than 35 states.
EGIDs are a group of diseases characterized by a
wide variety of gastrointestinal symptoms, including vomiting, swallowing problems, food impaction,
abdominal pain, diarrhea, slow growth, and bleeding.
These symptoms occur in combination with increased
numbers of eosinophils in the gastrointestinal lining.
Eosinophils are a type of white blood cell that have
been primarily associated with allergic diseases and
are also found in other diseases. Treatment is individualized and includes changes in the patient’s diet,
and/or inhaled, swallowed or oral steroids.
“Once we became aware of this disorder, we
realized that this is a population of patients we
had missed diagnosing in the allergy community,”
said F. Dan Atkins, MD, Co-Director of the GEDP
and Associate Professor of Pediatrics, University of
Glenn Furuta, MD, and Dan Atkins, MD,
examining a patient with his mother in
the Gastrointestinal Eosinophil Center
Colorado Denver School of Medicine (UCDSOM). “The more we ask the right questions, the more of these children we find. In the past 5 to 10 years we’ve been seeing
more and more of these children in our allergy practice. They often have allergic disorders and gastrointestinal symptoms. It’s a perfect disease for allergists and gastroenterologists to tackle together.”
The mission of the GEDP is to improve the quality of life for patients and families
affected by EGIDs. The program offers a comprehensive evaluation for patients suspected of having EGIDs and for children who have a previously established diagnosis.
Patients receive a thorough review of medical records, pathology slides, endoscopic
procedures, and allergy testing. In the GEDP clinic – which rotates between Children’s
26 D e p a r t m e n t o f P e d i a t r i c s
and National Jewish – patients receive a multidisciplinary evaluation by board-certified pediatric gastroenterologists and allergists, psychosocial and behavioral clinicians,
and nutritionists and pediatric feeding specialists. Care is coordinated by a physician
assistant and pediatric nurse and administrators at both institutions.
According to Dr. Atkins and Dr. Furuta, Director of the GEDP and Associate
Professor of Pediatrics, UCDSOM, the multidisciplinary component is important
to families. Patients and families now have access to several specialties during one
visit and in one location, which otherwise might have taken a month or more to
see individually.
“We have a team meeting every week to talk about our patients,” Dr. Atkins said.
“There is a carefully coordinated effort to provide a comprehensive, individualized
plan for each of our patients.”
Glenn Furuta, MD, and Dan Atkins, MD
“Children with EGIDs often complain of common symptoms, leading to a delay in
their diagnosis,” Dr. Furuta said. “It often takes a long time to recognize that something else might be wrong when children are not getting better with common management. Because these are chronic diseases, the quality of life with the disease and qual-
The mission of the GEDP is
ity of life with treatment are important to consider when we care for our patients.”
to improve the quality of
Research is an important component of the GEDP.
“Clinical research is examining quality of life with EGIDs, feeding dysfunction
associated with EGIDs, as well as novel methods of monitoring disease activity, since
presently endoscopy and biopsy are the only tools available to measure esophageal
life for patients and families
affected by EGIDs. The
inflammation,” Dr. Furuta said. “In addition, two novel treatment trials are underway. Basic research seeks to understand how the gastrointestinal function is affected
program offers a com-
by eosinophilic inflammation and to translate this information into new therapies.”
The GEDP is also a part of TIGERs (The International Gastrointestinal Eosinophil
Researchers), an international clinical research consortium. Dr. Furuta serves as chairman of TIGERs, which has received initial funding from the Bunning Family and
Food Allergy Initiative.
prehensive evaluation for
patients suspected of having
EGIDs and for children
The GEDP has received NIH research grant support, as well as funding from the
American Gastroenterological Association, the Pappas Foundation, the Campaign
who have a previously
Urging Research for Eosinophilic Disease, and other philanthropic support.
Drs. Furuta and Atkins – and the entire GEDP team – are also committed to edu-
established diagnosis.
cating the community about EGIDs. Members of the GEDP have given a number
of lectures and audio broadcasts on the Web, organized international meetings, and
recently published a book about these diseases. In addition, they work with the advocacy group American Partnership for Eosinophilic Diseases (APFED.org) to advocate
for children and adults with these diseases.
“Our unbelievable team of talented individuals is committed to utilizing our expertise to provide outstanding patient care, to make discoveries that will translate into
improved quality of children’s lives, and to educate the academic and public communities in the area of EGIDs,” Dr. Furuta said.
2006-2008 Departmental Report
27
DE PA R T M E N T F E AT U R E 2 0 0 6 – 2 0 0 8
custom web-based software
streamlines academic affairs
Faculty Information Database Online (FIDO)
F
aculty and administrators in the Department of Pediatrics have a new tool that has
streamlined – and simplified – the process of managing academic appointments.
The Faculty Information Database Online (FIDO) was launched in January 2008.
This custom Web-based software manages many aspects of faculty data, including
academic rank and appointments, faculty annual reviews, research interests, and
administrative appointments. With its launch, the
Department of Pediatrics became one of the first
pediatric departments in the nation to implement an
electronic system to manage academic affairs.
Peg Christon, MD, MSCIS, Director of the Faculty
Information Database On-Line (FIDO), helped
build a system several years ago for the UCDSOM
Department of Medicine called DOMINO. She
was able to bring that software to the Department
of Pediatrics and enhance and adapt it to the
Department’s needs. The result is a database that has
replaced Excel spreadsheets, Access tables, and many
paper-based processes for the approximately 500
faculty and 21 administrators in the Department.
“Our first priority was to serve as the new forum
for all annual faculty reviews. That was accomplished and everyone did it, we had 100 percent parFIDO Team l-r:
Harley Rotbart, MD,
Peg Christon, MD, MSCIS,
Monica Younger, MS
ticipation,” Dr. Christon said. “After that process we did a survey to see what the faculty thought of the software. 73 percent rated their experience as �excellent’ or �good.’
Overall it was a really positive response.”
FIDO allows a faculty member to log on, select his or her reviewer/supervisor, fill
out the review, and submit it. Then the system automatically routes it to the reviewer,
who receives an e-mail message indicating that a review is awaiting their comments.
They log on, review what the faculty member entered, fill in their comments and discuss them with the faculty member. Then the reviewer submits their comments.
28 D e p a r t m e n t o f P e d i a t r i c s
The review gathers a wealth of information, including clinical work, research activities, research focus, grants, advocacy, patents, service, and administration. Faculty
members and reviewers can work on the review, save their data, finish it at a later
time, and submit it when complete; it then moves through the routing. Final comments are added to each review by Department Chairman Stephen R. Daniels, MD,
PhD. The annual review process is an important way for the Department to foster
mentoring and career development for the faculty.
“Most of the review is confidential, and we clearly outline in a privacy policy what
is shareable and what is private,” Dr. Christon said. “The research piece is shareable.
Now people can use a new keyword search engine to look up research information on
a faculty member’s profile; that’s valuable for collaborations and mentoring.”
In addition to keyword search, the search engine allows users to look up faculty by
“Some of the most consistent
last name or section in the Department. The application also offers special reports for
section heads, administrators, and academic affairs staff. Reports include faculty lists
by section and by rank. Reports can be viewed on the screen as html, or exported
to a PDF or Excel file. A limited number of administrators can access a section that
manages who the faculty are and tracks all demographic and appointment information.
positive comments from the
faculty survey were that it’s
easy to use, they love that it’s
“Administrators in this Department have never had a single good source of data
on all faculty in the Department until now,” Dr. Christon said. “Many people were
computer-based, and they
keeping their own lists, there were duplications, and data was out of sync. This is a
huge step forward, and a move away from paper processes, Excel sheets, and that
sort of thing.”
The Department of Pediatrics has its own domain name and the FIDO application
runs on servers that are hosted by UCD. The site is secure; all faculty and administra-
like that they could do a little
bit, save it and come back
and work on more later.”
tors have their own login and password. Dr. Christon and Monica Younger, MS, run
the helpdesk, which allows submissions of “tickets,” where users can indicate that
—Peg Christon, MD, MSCIS
they are having difficulty or ask a question. All helpdesk tickets are tracked through a
central helpdesk e-mail address.
Dr. Christon said FIDO users have made a number of requests to enhance the system. Requests are being reviewed and prioritized by the Department and continually
being added to the software. Some of the enhancements incorporated recently include
the addition of a spell checker, a section to track patents, the new search engine and
faculty profiles, and many enhancements to the annual review form.
“Some of the most consistent positive comments from the faculty survey were that
it’s easy to use, they love that it’s computer-based, and they like that they could do a
little bit, save it and come back and work on more later,” Dr. Christon said.
“This coming year, faculty will be able to take last year’s review and import it into
the new review so they don’t have to re-enter everything – they can edit what they
entered last year,” Dr. Christon added. “They are looking forward to that!”
2006-2008 Departmental Report
29
DE PA R T M E N T F E AT U R E 2 0 0 6 – 2 0 0 8
complete medical records
at our fingertips
Electronic Medical Record System
I
n mid-2007, The Children’s Hospital (TCH) became the first free-standing pediatric
hospital in the nation to fully implement an integrated Electronic Medical Record
(EMR) system (according to the research firm, KLAS).
This achievement enables pediatric physicians and other care providers to access
patient records electronically through secure technology whether they are at TCH,
their office, an outside clinic, or another location. EMR eases care delivery by allowing authorized providers to view all pertinent patient
data in one place, including past medical history,
lab results, consults from subspecialists, images and
reports, and orders.
“For the first time, we have everything we need
available at our fingertips,” said David Kaplan,
MD, MPH, Chief Medical Information Officer and
Head of Adolescent Medicine at TCH and Professor
of Pediatrics at the University of Colorado Denver
School of Medicine (UCDSOM). “Documentation
is much more complete than ever before. It’s more
organized; notes are not missing as sometimes would
be the case with paper records.”
TCH is also the first pediatric hospital to integrate
an EMR system that includes child abuse services.
A novel, model way of charting abuse reports, the
system uses a SCAN (Suspected Child Abuse and
David Kaplan, MD, MPH
Neglect) encounter. “We can effectively report out how many children are reported
as suspected child abuse cases, for what reason or diagnosis, and from what unit
or area,” explained Andrew Sirotnak, MD, Director of the Kempe Child Protection
Team (CPT), Department Head of Child Abuse and Neglect, and Associate Professor
of Pediatrics at UCDSOM.
During the reporting, a hyperlink flags the chart as a previously reported case, so
any user can access this data anywhere in the hospital’s Network of Care. In addition, the CPT Clinic can upload sensitive photos to a secure server. It’s just one of the
many ways the system is changing the delivery of pediatric healthcare.
30 D e p a r t m e n t o f P e d i a t r i c s
Transition Put EMR on Fast Track
TCH aggressively pursued the implementation to meet the needs of the move to its
new location. “There was urgency to get the new record system implemented for both
the outpatient clinics and all the inpatient units and ensure we had a system that was
stable and efficient before we moved,” explained Dr. Kaplan.
Launching EMR was challenging: users encountered, and expected, difficulties during the implementation.
“It’s a work in progress, not just a simple installation,” Dr. Kaplan emphasized.
Children’s is partnering
“We are understanding how to use the tools in the EMR to provide more consistent, evidence-based care to our patients with the obvious goal of improving patient
outcomes,” added Michael Narkewicz, MD, Hewit-Andrews Chair in Pediatric Liver
Disease, Professor of Pediatrics at UCDSOM, and Director of Clinical Services for
Pediatric Gastroenterology at TCH.
Children’s vendor, EPIC, applauded the team on an impressive installation and
honored the hospital with a coveted “Good Install” award.
with three other health care
organizations – Denver
Health, Kaiser Permanente
of Colorado, and the
Now, with the EMR rolled out, the team is exploring ways to leverage the system’s
University of Colorado
extensive capabilities.
“It’s important that we challenge EMR, ourselves, and the institution to be excellent
and not accept average from ourselves or the systems that we use,” Dr. Kaplan noted.
“Children’s patients and their families can expect better, high-quality care because
we are centralizing clinical information to make it readily available to verified clinicians when and where they need it,” explained Dena Somers, Director of Clinical
Hospital – in an innovative
pilot to develop an electronic health information net-
Application Services.
“What is really exciting is that we have many modalities in place that are not in use
at other pediatric institutions,” Dr. Kaplan said. “And now, [our peers] are calling us
with questions about our process!”
work enabling authorized
care providers to share vital
health information.
Children’s participating in innovative health information exchange pilot
With the EMR in place and access to patient data streamlined, TCH is part of a
partnership to electronically share that data. Children’s is partnering with three other
health care organizations – Denver Health, Kaiser Permanente of Colorado, and the
University of Colorado Hospital – in an innovative pilot to develop an electronic
health information network enabling authorized care providers to share, and have
access to, vital health information when and where they need it.
Colorado is one of six states piloting this important project headed by the
Colorado Regional Health Information Organization (CORHIO), a not-for-profit
regional health information organization to facilitate health information exchange to
improve care for all Coloradans. Colorado received support from federal and local
grants and contracts to begin network development. This work began with a contract
awarded in fall 2004 by the Agency for Healthcare Research and Quality.
2006-2008 Departmental Report
31
EMR
The system is based on a platform that interfaces with different sources and
computer hardware to seamlessly link the partnering sites. The system does not
store clinical data; the patient’s data resides at the source to be shared only when
an authorized ED user requests the information via a secure connection that ensures
patient confidentiality.
When a patient is admitted to the emergency department, they receive a fact sheet,
available in English and Spanish, about the pilot, and they are given the choice to opt
out. For patients who opt out, their information is not shared. The system is linked
to the three other hospital emergency departments, Kaiser’s urgent care location in
Englewood and its nursing triage line. Authorized users are able to electronically
access, via a secure connection, a patient’s medical history, including labs, imaging
results, EKG wave forms, problem lists, and current medications. Any additional
information and/or results the provider requires must be requested via a traditional
Release of Information form.
The system is off to a successful start. Already, one major benefit is a reduction of
costly duplication of services.
“Overall, Children’s participation in this joint effort is in line with our mission,
vision, and values,” said Kim Peterson, RHIA, Health Information Management
Application Coordinator. “It made sense to rise to the call as we are a leader in the
metro area and have a fully integrated electronic medical record. This effort is in sync
with who we are.”
The EMR will help Dr. Rupa Narra offer more comprehensive care while ensuring patient confidentiality
32 D e p a r t m e n t o f P e d i a t r i c s
2 0 0 6 – 2 0 0 8 DE PA R T M E N T F E AT U R E
increased research into
down syndrome
Linda Crnic Down Syndrome Institute
A
new University of Colorado Denver institute will provide
increased research into Down syndrome and more compre-
hensive care for patients with Down syndrome. The Linda Crnic
Down Syndrome Institute is a cooperative program with The
Children’s Hospital and University of Colorado at Boulder.
The Linda Crnic Down Syndrome Institute will consist of
basic science research at University of Colorado at Boulder and
University of Colorado Denver, clinical and translational research
at University of Colorado Denver and The Children’s Hospital,
and patient care that will be provided through the Anna and
John J. Sie Center for Down Syndrome at The Children’s
Hospital. The comprehensive Sie Clinical Center for Down
Syndrome will be the first of its kind in the Rocky Mountain
Region. It is being funded by a $2 million gift from the Anna
and John J. Sie Foundation.
“The Sie Center for Down Syndrome will provide, locally
and globally, the highest quality clinical care, therapeutic development, including physical, occupational, and speech therapies,
medical care, societal education, and advocacy in the pursuit of
its mission,” said Stephen R. Daniels, MD, PhD, Pediatrician-inChief at The Children’s Hospital. “Our experts from a variety
of fields will have the opportunity to catch medical issues early
so the outcomes for children with Down syndrome will be
Patricia Winders, PT, with her patient
greatly improved.”
The Sie Clinical Center for Down Syndrome will provide medical care to children
with Down syndrome, hire and mentor a medical “dream team,” provide up-to-date
information on Down syndrome to women who have received a prenatal diagnosis
of Down syndrome, and participate in collaborative ground-breaking clinical trials.
Linda Crnic is a former faculty member of the Department of Pediatrics and served
as director of the Colorado Mental Retardation and Developmental Disabilities
Research Center. She passed away in 2004.
2006-2008 Departmental Report
33
Notables
St. Geme Lectureship
T
he Joseph W. St. Geme, Jr., MD, Lectureship was
established in 1987 by the Chancellor’s Office,
University of Colorado
Denver, and the eight chairs
of the departments in the
School of Medicine who were
recruited by Dr. St. Geme.
Dr. St. Geme was Dean of
the University of Colorado
Denver School of Medicine
from January 1985 to
October 1986, just shy of
Joseph W. St. Geme, Jr., MD
21 months. In his short ten-
ure, he is credited with helping to transform the medical
school to a modern research-oriented academic center.
Dr. St. Geme held an academic faculty position in the
Department of Pediatrics during his tenure as Dean.
The St. Geme family, in honor of Dr. St. Geme,
also has supported the St. Geme Lectureship and the
Audrey Brumback, PhD, 2007 Medical Student Award Recipient with
Stephen Daniels, MD, PhD
Joseph W. St. Geme Memorial Endowment. As part
of this, each year the Joseph W. St. Geme, Jr., MD,
Award for Outstanding Research by a Resident is
given by the Department of Pediatrics. A second award
is given at the Lectureship to a deserving fourth-year
medical student who has demonstrated outstanding
research with a mentor and who is interested in a career
in academic pediatrics.
The 2007 Medical Student Award was given to
Audrey C. Brumback, PhD, MSIV, along with her mentor, Kevin J. Staley, MD. The 2007 St. Geme Lectureship
speaker was Oliver Smithies, PhD, who spoke on,
“Chance, Opportunity and Planning in Science.”
Dr. Smithies is Excellence Professor of Pathology and
Laboratory Medicine at University of North Carolina at
2007 St. Geme Lectureship Speaker, Oliver Smithies, PhD
Chapel Hill School of Medicine; and he was a co-recip-
helped scientists use mice to study heart disease, diabetes,
ient of the 2007 Nobel Prize in Physiology or Medicine
cancer, cystic fibrosis, and other diseases.
for his contributions to the “discoveries of principles for
In 2008, the St. Geme Medical Student Award was
introducing specific gene modifications in mice by the
given to Christina Seng Chao, PhD, an outstanding
use of embryonic stem cells.” This technique for manipu-
fourth-year medical student who has demonstrated sub-
lating mouse genes is a widely used process that has
stantial research with her mentor, Lori Sussel, PhD. The
34 D e p a r t m e n t o f P e d i a t r i c s
Notables
Dr. Richard Spritz introducing his mentor, Dr. Oliver Smithies
Drs. Stephen Daniels and Lori Sussel with Christina Seng Chao, PhD, (right),
2008 Medical Student Award Recipient
St. Geme Family l-r: Cecil H. St. Geme, Edmond St. Geme, Elodie St. Geme Cassidy,
Joseph W. St. Geme III, MD, Lynn White St. Geme, MD, Monica St. Geme, Catherine Cassidy.
Not pictured: Peter St. Geme, Mary Louise St. Geme Bowe, Robert St. Geme
2008 St. Geme Lectureship speaker,
Joseph W. St. Geme, III, MD
2008 Lectureship speaker was Joseph W. St. Geme, III,
has been recognized for his research into the genetic and
MD, the son of Dr. St. Geme. He spoke on “Bacterial
molecular basis of virulence by Haemophilus influenzae,
Versatility: The Balance between Commensalism and
a bacterium that causes middle ear infections, bronchi-
Disease.” Dr. St. Geme is Chairman of the Department
tis, sinusitis, pneumonia, and meningitis. He has been
of Pediatrics at Duke University Medical Center, and he
involved in efforts to create a pediatric vaccine to pre-
is a nationally recognized expert in basic research and
vent these widespread infections, which are often fatal in
clinical treatment for pediatric infectious diseases. He
developing countries.
2006-2008 Departmental Report
35
Notables
Four Faculty Members Honored
During Annual Pediatric
Academic Societies Meeting
James K. Todd, MD, was given the Distinguished
n
Physician Award of the Pediatrics Infectious Disease
Society. This award is presented annually to a pedia-
F
trician who has an extensive and distinguished career
meeting, which was held in May 2008, at the Hawaii
those as a clinician, educator, and/or investigator.
our Department of Pediatrics faculty members were
in pediatric infectious diseases, marked by signifi-
honored at a reception of the American Pediatric
cant accomplishments and contributions, including
Society during the Pediatric Academic Societies’ annual
The pediatrician’s accomplishments and contribu-
Convention Center in Honolulu, Hawaii.
tions are nationally and internationally recognized
for their excellence and support the Society’s mission
to advance the knowledge of pediatric infectious diseases and its application to the care of children.
William W. Hay, Jr., MD, was installed as President
n
of the Pediatric Academic Societies.
Festschrift Symposium for
M. Douglas Jones, Jr., MD
O
n October 5 and 6, 2006,
M. Douglas Jones, Jr., MD,
L-R: James Todd, MD, M. Douglas Jones, Jr., MD, Richard Johnston, Jr., MD
Not pictured: William W. Hay, Jr., MD
Chair of the American Board
of Pediatrics, and former Chair
M. Douglas Jones, Jr., MD, Chair of the American
of Pediatrics at University of
n
Board of Pediatrics, and former Chair of Pediatrics at
Colorado Denver School of
University of Colorado Denver School of Medicine,
Medicine, was honored with a
was the 2008 recipient of the Joseph W. St. Geme,
Festschrift symposium entitled,
Jr., Leadership Award. The award was given during
the plenary session of the American Pediatric Society
n
M. Douglas Jones, Jr., MD
“The Future of Pediatrics.”
Dr. Jones was honored for his life-long contributions to
and honors an individual who has extraordinary lead-
pediatrics as an investigator, educator, clinician, national
ership skills, has been a role model for others to emu-
leader, and Chair of the Department of Pediatrics. His
late, and, in the tradition of Dr. St. Geme, has created
contributions, say colleagues, have helped shape the
a future for pediatrics. The award was established by
direction of pediatric training and career development
member constituents of the Federation of Pediatric
over the past two decades and promise to reshape the
Organizations to honor the life, work, and memory
future of pediatrics. In addition, “The Future of Pediatrics:
of Dr. St. Geme and to memorialize his many contri-
A Festschrift for M. Douglas Jones, Jr., MD,” was
butions to pediatrics.
published in November 2007 as a Supplement to The
Richard B. Johnston, Jr., MD, was named the 2008
Journal of Pediatrics. Ronald J. Sokol, MD, Professor
John Howland Medal Awardee. The American
and Vice Chair of Clinical and Translational Research,
Pediatric Society’s highest award in North America,
Department of Pediatrics, University of Colorado
the John Howland Medal has been given since 1952
Denver School of Medicine, and Stephen R. Daniels,
to honor those who, by their contribution to pediat-
MD, PhD, Chairman of the Department of Pediatrics,
rics, have aided in its advancement.
University of Colorado Denver School of Medicine,
served as co-guest editors for the Supplement.
36 D e p a r t m e n t o f P e d i a t r i c s
Teamwork
2 0 0 6 – 2 0 0 8 DE PA R T M E N TA L R E P O R T
sections, programs,
and affiliates
Boettcher Atrium, The Children’s Hospital
sections
Adolescent Medicine
Clinical Services
The Adolescent Medicine Clinic at The Children’s
Hospital (TCH) offers a full range of primary, secondary, and tertiary health care to teenagers in the Denver
metropolitan area. Consultative services are provided
to adolescents with complex physical and emotional
problems who are referred from throughout the Rocky
Mountain area.
The Pediatric and Adolescent Gynecology Clinic
at TCH includes a multidisciplinary team combining
adolescent medicine physicians and gynecologists.В The
providers have expertise in working with children, adolescents, and young adults with menstrual irregularities
and menstrual disorders, pelvic pain, abnormal Pap
Adolescent Medicine Front row, l - r: Daniel Reirden, Eric Sigel;
Middle row, l - r: David Kaplan, Molly Richards, Jeanelle Sheeder,
Angela Gurule; Back row, l - r: Amy Sass, Elizabeth Romer,
Karolyn Kabir, DeTerri Rockwell
smears, and vaginitis; and they provide contraception
Research
consultations and menstrual management for patients
The Adolescent Medicine faculty is interested in an array
with chronic diseases.
of issues dealing with the major morbidity and mortal-
The Eating Disorders Program at TCH is recognized
ity of this age group, including health services delivery,
nationally for the management ofВ children, adolescents,
violence, sexual health and disease, teenage pregnancy,
and young adults, providingВ a range of levels of care:
violence, mental health, and gynecologic disorders.
inpatientВ medical, inpatient eating disorder, day treat-
Dr. Karolyn Kabir’s research interests focus on
ment, intensive outpatientВ program, outpatient care, and
ways to improve the identification and treatment of
consultation clinic services.
antenatal and postpartum depression in teen mothers.
The Colorado Adolescent Maternity Program
In addition, Dr. Kabir is working alongside colleagues
(CAMP) at TCH is a multidisciplinary prenatal and
from the Colorado Adolescent Maternity Program
postnatal program that serves young mothers under the
(CAMP) to develop and implement a nurse-centered/
age of 21 and their children. The mission of CAMP is
group-based model of care for teen mothers and their
to reduce the incidence of preterm and low-birth-weight
children. Dr. David Kaplan’s current research interests
teen deliveries, help families who have experienced one
include evaluating the impact of school-based health
teen pregnancy prevent others, and increase the numbers
centers on child and adolescent access to health care,
of teen parents and their siblings who graduate from
utilization, and health status. Supported by the Robert
high school and become active, productive community
Wood Johnson Foundation, Dr. Kaplan developed
members and nurturing, non-abusive parents. A case
an electronic problem-orientated clinical information
management format is used to meet the unique medi-
system that is designed to facilitate both clinical care
cal, nutritional, psychosocial, and educational needs of
and outcomes-based research. The software is used in
these patients with professional services provided by
over 1,000 school-based health centers nationally.
physicians, nurse midwives, physician assistants, a social
Dr. Kaplan is also collaborating with colleagues in
worker, and a nutritionist.
India to study the prevalence of sexually transmitted
infections in Indian adolescents. Dr. Daniel Reirden’s
current research interests include sexually transmitted
38 D e p a r t m e n t o f P e d i a t r i c s
sections
infections in adolescents, particularly among HIV-
elective in adolescent medicine is available for fourth-
infected adolescents and young adults. Dr. Amy Sass
year medical students who have successfully completed
is interested in resident education and is a School of
a pediatric clerkship.
Medicine Teaching Scholar. She is developing a curriculum for multidisciplinary resident trainees in pediatric
Highlights
and adolescent gynecology. Dr. Sass is also studying
David Kaplan was given the Milton J.E. Senn Lecture-
an outbreak of vulvar ulcers of unknown etiology in
ship Award by the AAP Council on School Health.
young adolescents. Jeanelle Sheeder, MSPH, is interested
Adolescent Medicine Faculty
in adolescent pregnancy, psychosocial and behavioral
components of contraceptive use and decision-making,
and obesity.В With support from the NIH, Ms. Sheeder
developed the Electronic Report on Adolescent
Pregnancy (ERAP), which is a clinic management and
decision-making tool and interactive databaseВ that
includes more than 15 years of detailed clinical data on
adolescent pregnancy and contraceptive use. ERAP has
allowed for exploration of numerous research questions
by faculty, graduate and medical students, residents,
and fellows and has resulted in numerous publications.
Dr. Eric Sigel is currently involved in two research areas.
He is developing a research path focused on adolescents
and violence, creating a screening tool that will help
identify teens in the primary care setting who are at
risk for future violence involvement. Additionally, he is
Faculty
David W. Kaplan, MD, MPH**
Professor of Pediatrics
Section Head, Adolescent Medicine
Chief Medical Information Officer
Karolyn Kabir, MD**
Assistant Professor of Pediatrics
Paritosh Kaul, MD***
Associate Professor of Pediatrics
Kathryn Love-Osborne, MD***
Associate Professor of Pediatrics
Daniel H. Reirden, MD*
Assistant Professor of Pediatrics
DeTerri Rockwell, PA-C
Instructor of Pediatrics
S. Elizabeth Romer, ND, MSN, FNP
Instructor of Pediatrics
Amy E. Sass, MD, MPH
Assistant Professor of Pediatrics
Eric J. Sigel, MD
Associate Professor of Pediatrics
Fellowship Director
Fellows
Alka Gulati, MD (2008-2009)
Karolyn Kabir, MD (2005-2007)
Molly Richards, MD (2007-2009)
Administrative Staff
Angela Gurule
Staff Assistant and Program
Coordinator
* Infectious Diseases Faculty
* General Academic Pediatrics
Faculty
**Denver Health Faculty
**Children’s Outcomes Research
Program Faculty
**Prevention Research Center
a co-investigator studying the effects of Risperidone in
patients with anorexia nervosa.
Jeanelle Sheeder, MSPH
Senior Instructor of Obstetrics and
Gynecology and Pediatrics
Faculty
Education
Allergy, Immunology
and Rheumatology
The Section of Adolescent Medicine sponsors an
Clinical Services
ACGME-certified three-year fellowship program, train-
The Allergy, Immunology and Rheumatology Section is
ing the next generation of adolescent medicine academi-
an integrated program between National Jewish Health
cians and clinicians. Two fellows have recently gradu-
(NJH) and The Children’s Hospital (TCH). The Allergy
ated, with one new fellow starting each year. Clinical
and Immunology Section at TCH provides both ambu-
training during residency includes experience with
latory and inpatient consultation services for children
primary adolescent health care and specific problems
with all forms of allergic, hypersensitive, and congenital
common during adolescence, including abnormalities of
immune deficiency disorders. Asthma care is coordinated
growth and development; orthopedic and sports medi-
between the Allergy and Immunology and Pulmonology
cine problems; issues relating to sexuality and reproduc-
Sections. Together with the Section of Gastroenterology,
tive health; psychosocial, mental health, and substance
Hepatology and Nutrition, clinics in eosinophilic
abuse problems; and the management of teenagers with
gastrointestinal disorders are held at both NJH and
chronic illnesses and recurrent somatic symptoms. An
TCH, supervised by physicians based both at TCH and
2006-2008 Departmental Report
39
sections
NJH. In collaboration with the Section on Infectious
Diseases and the Department of Otolaryngology,
Dr. Andrew Liu staffs a multidisciplinary Sinus Clinic.
The Section of Rheumatology at TCH and NJH
diagnoses and treats rheumatic and musculoskeletal
diseases of childhood, including arthritis, lupus, and vasculitis. В The rheumatology team works closely with the
referring physician and other specialists to coordinate
care and treat all aspects of a patient’s illness.  In collaboration with the Section of Hematology, Oncology
and BMT, Dr. Jennifer Soep staffs a multidisciplinary
Antiphospholipid Antibody Clinic. Additionally, Drs.
Allergy, Immunology and Rheumatology l - r: Michelle Sutter,
Leonard Dragone, J. Roger Hollister, Jennifer Soep, Flor Ibarra
Jennifer Soep and J. Roger Hollister, in collaboration
with the Section of Nephrology, participate in a monthly
center research through NIH-funded consortiums.
combined Nephrology/Rheumatology Clinic to provide
Dr. J. Roger Hollister’s research in rheumatology
comprehensive care to patients with renal manifestations
focuses on innovative treatment for Wegener’s
of their rheumatologic condition.
Granulomatosis.В Dr. Jennifer Soep has been conducting research on atherosclerosis in Systemic Lupus
Research
Erythematosus (SLE) and is participating in a joint
The faculty at National Jewish Health (NJH) and TCH
project between TCH and the University of Colorado
have numerous research interests with major programs
Denver Division of Adult Rheumatology to investigate
in the regulation of allergic responses, asthma, inflam-
the role of complement receptor 2 and the development
mation, autoimmunity, inflammatory cell function,
and manifestations of SLE.
signal transduction, apoptosis, and compliance issues.
In addition, the entire rheumatology division is involved
Education
with multicenter research studies through the Childhood
The Section has a strong commitment to educating all
Arthritis and Rheumatology Research Alliance, includ-
levels of trainees in pediatric rheumatology. В Our faculty
ing ARCHIVE (A Registry for Children with Vasculitis:
teach residents in our busy outpatient rheumatology
e-entry), a project towards establishing a computerized
clinic as part of the dermatology/rheumatology elec-
database of children with vasculitis and EDSS (Enhanced
tive. We also provide informal teaching sessions on the
Drug Safety Surveillance), a study designed to capture
wards and didactic lectures to the residents and students
all serious adverse events and important medical events
on common rheumatologic topics. We participate in
in patients with Juvenile Idiopathic Arthritis. В the musculoskeletal block for the third-year medical
 Dr. Leonard Dragone’s research lab focuses on under-
students and the rheumatology pathophysiology course
standing how alterations in lymphocyte signaling path-
for the first-year students at the School of Medicine.
ways underlie the development of autoimmune diseases
We assist in the training of the adult rheumatology fel-
such as juvenile idiopathic arthritis, rheumatoid arthritis,
lows from the University of Colorado Denver to provide
and Systemic Lupus Erythematosus. Dr. Erwin Gelfand
exposure to pediatrics.
runs a research laboratory at NJH that focuses on understanding the pathophysiology and treatment of allergy,
Information about the allergy and immunology fellowship
asthma, and immunodeficiency. He is involved in multi-
program can be found under National Jewish Health.
40 D e p a r t m e n t o f P e d i a t r i c s
sections
Allergy, Immunology and Rheumatology Faculty
Erwin W. Gelfand, MD**
Professor of Pediatrics
Chairman, Department of Pediatrics,
National Jewish Health
Section Head, Allergy, Immunology
and Rheumatology
Vice Chair, Affiliate National Jewish
Health
Leonard L. Dragone, MD, PhD
Assistant Professor of Pediatrics
and Immunology
J. Roger Hollister, MD
Professor of Pediatrics
Jennifer B. Soep, MD•
Assistant Professor of Pediatrics
Director, Clinical Clerkship in Infant,
Child and Adolescent Care
** National Jewish Health Faculty
•
Medical Education Faculty
Cardiology
standing commitment to the understanding and treatment of pulmonary hypertension continues to be at the
forefront of the Section’s clinical and basic research.
The Section has recently opened an Adult Congenital
Heart Disease Program in conjunction with the
Cardiology Division at UCD. Our Fetal Cardiology and
Marfan Syndrome clinics offer state-of-the-art care. Our
Cardiac Intensive Care Unit (CICU) is staffed by dedicated cardiac intensive care physicians with international
experience, and, together with the Section of Cardiac
Surgery, they operate the Ventricular Assist Device
Clinical Services
program. In conjunction with the CICU, the Section of
The Section of Cardiology functions within the auspices
Cardiology has developed a state-of-the-art simulation
of The Children’s Hospital Heart Institute. The clini-
program using the Sim-Baby to teach residents, fellows,
cal service is designed to provide the highest quality
and nursing staff the principles of resuscitation.
of cardiac care in the most efficient fashion to more
than 11,000 children treated annually: 8,000 at The
Research
Children’s Hospital, 2,500 in the community settings in
Research efforts are designed to promote more effec-
the metropolitan area, and 1,000 in the tri-state region.
tive treatments for complex heart problems. Clinical
The Section strives to deliver the same level of excel-
research activities in the Cardiac Transplant Program
lence for simple problems, such as innocent cardiac
have resulted in new therapies with a friendlier environ-
murmurs, as it does for the most complex of problems
ment, including discharge home for the child awaiting
requiring extensive repair by surgery or even a cardiac
transplantation. Other transplant-related research has
transplantation. The approach is comprehensive, and
found new avenues of manipulation for the immune
the goal is rehabilitation back to a normal lifestyle. The
system that have strikingly reduced the amount of rejec-
Section also provides a preventative cardiology program,
tion of the transplanted heart. Basic research on immu-
which is both diagnostic and therapeutic and includes
nologic models is performed in collaboration with the
the Shapedown Program for childhood obesity. Faculty
Barbara Davis Center for Childhood Diabetes at UCD.
members have made pioneering advances in the treat-
These technologies allow new insights into the process
ment of end-stage cardiac disease and the use of inter-
of organ tolerance, giving great hope for possibility of
ventional catheterization procedures to prevent the need
transplantation without chronic immunosuppression,
for surgical repair or to improve the outcome following
and even the possibility of xenotransplantation.
surgery. New devices are being used to close defects, on
Both basic and applied experimental studies are
an outpatient basis, that previously required surgery.
conducted on techniques/devices to repair heart defects
Other technologies can “stent” open obstructive blood
(i.e., ASD, VSD, HLHS) without surgery. Collaborative
vessels, allowing for normal growth and development.
efforts with the Biomechanical Engineering Department
Newer technologies for cardiac imaging allow for more
at the University of Colorado at Boulder, as well as
precise quantification of blood flow and three-dimen-
the private community and adult cardiology programs
sional reconstruction of cardiac structures and blood
at UCD, ensure relevant cutting-edge research in
flow. The Cardiac MRI Program is rapidly growing
blood flow. Measurements of valve function and arte-
and performed more than 150 studies in 2008. A long-
rial remodeling with in vitro mock-up systems offer a
2006-2008 Departmental Report
41
sections
Cardiology Front row, l - r: Sara Mackie, Jilayne Smith, D. Dunbar Ivy, Faith Fisher-Halpern, Adel Younoszai, Kendall Hunter, Suzanne Osorio-Lujan;
Middle row, l - r: Amy Stimmler, Karrie Villavicencio, Alison Ballard, Denise Kaufholz, Michael Schaffer, Elizabeth Shaffer, Shelley Miyamoto,
Biagio Pietra; Back row, l - r: Alison Dumond, Jessica Church, Brian Fonseca, Biff Landeck, Jonathan Kaufman, Joseph Kay, Eduardo da Cruz
greater understanding than would ever be possible in the
of blood pressure elevation and cholesterol abnormali-
complex environment of the body.
ties in children and adolescents, particularly the role that
There is a key basic research initiative to understand
obesity may play in these health issues; development of
the remodeling of pulmonary arteries in response to
structural and functional abnormalities in the heart and
abnormal pressures and new ways of treating these high
vascular system, including cardiovascular abnormalities
pressures. This laboratory research program is conduct-
occurring in pediatric patients with diabetes mellitus; as
ed in collaboration with a large clinical program to test
well as the relationship of left ventricular hypertrophy
new drugs for children with pulmonary hypertension.
to obesity and hypertension. The role of lifestyle factors,
Additional ongoing studies assess the impact of various
such as diet and physical activity, is central to many of
heart surgeries on long-term rehabilitation patients and
Dr. Daniel’s studies. Dr. Karrie Dyer Villavicencio pur-
ways to improve diagnostic and interventional catheter-
sues research in echocardiography, pulmonary hyperten-
izations. There is a major research effort in understand-
sion, tissue Doppler and fetal echocardiography.
ing the circulation of children with only a single ventri-
Dr. Thomas Fagan’s research interests include develop-
cle. Particularly, we are performing computer modelling
ment of a balloon-expandable vascular conduit, septal
on children whose venous circulation to the lungs is
defect occlusion devices, atretic pulmonary valves, MRI
provided by passive flow rather than a right ventricle.
evaluation of coarctation stent placement and low-profile
Dr. Dennis Chang’s research interests include 3-D
stents, and long-term factors associated with subpulmo-
reconstruction of cardiac structures using biplane
nary artery obstruction. Dr. Brian Fonseca is pursuing
angiography. Dr. Eduardo da Cruz is interested in and
research in cardiac MRI measures of pulmonary hyper-
pursues research in nutrition of the critically-ill cardiac
tension severity. Dr. Kendall Hunter’s research interests
patient; new monitoring technologies; and cardiovascu-
include cardiovascular biofluid mechanics; computational
lar drugs. Dr. Stephen Daniels is interested in the causes
simulation of cardiovascular dynamics; mechanics-based
42 D e p a r t m e n t o f P e d i a t r i c s
sections
diagnostics of pulmonary arterial hypertension (PAH);
pressure tracking, and altitude-specific systemic
importance of vascular stiffness in diagnosis; and hemo-
blood pressure in a tri-racial pediatric population.
dynamics in animal models of PAH. Dr. Jill Ibrahim’s
Dr. Adel Younoszai’s research interests include digital
research interests include cardiac intensive care, cardiac
information technology, Marfan syndrome, the use of
transplant and mechanical support. Dr. D. Dunbar Ivy
Doppler imaging in pediatric cardiography, and fetal
is interested in research involving pulmonary hyperten-
cardiac intervention.
sion, genomics, and proteomics of pulmonary vascular
disease. Dr. Jonathan Kaufman’s research and clinical
Education
interests include management of congenital heart disease
The UCDSOM Department of Pediatrics and TCH offer
in neonates and infants, endocrinology of critical illness,
a three-year fellowship in pediatric cardiology, which is
resident and fellow education, and medically under-
fully accredited. The goal of the fellowship is to provide
served communities. Dr. Joseph Kay investigates out-
physicians who are board eligible in pediatrics with in-
comes and therapies for children and adults with con-
depth training in cardiology that will prepare them for
genital and valvular heart disease. Dr. Bruce Landeck is
a career in clinical or academic medicine. Training for
interested in noninvasive means of evaluating ventricular
residents in pediatric cardiology involves intensive clini-
function and synchrony, particularly using 3-D echocar-
cal training in all aspects of clinical pediatric cardiology,
diography. Dr. Biago Pietra’s research relates to cardiac
as well as development of clinical and/or basic research
allograft rejection. Dr. Michael Schaffer’s research
skills. Pediatric cardiology is an integral component of
examines electrophysiology, pediatric nuclear cardiology,
the pediatric clerkship curriculum for third-year medical
pulmonary hypertension, and myocardial development
students at UCD. Our faculty provides a lecture in car-
in bronchopulmonary dysplasia. Dr. Elizabeth Shaffer is
diology as part of the clerkship’s core lecture series. An
interested in echocardiography, including fetal echocar-
elective in pediatric cardiology is available for fourth-
diography, and cardiac MRI. Dr. Robin Shandas teaches
year medical students who have successfully completed
and performs research in cardiovascular bioengineering,
a pediatric clerkship.
with specific focus on diagnostics and imaging in pulmonary hypertension, novel shape memory materials
Highlights
for minimally invasive medical devices, a novel artificial
n
Jonathan Kaufman received the Outstanding Young
right ventricle for congenital heart disease, and medical
Investigator Cardiology Award from The Children’s
ultrasonics. Dr. Wei Tan’s primary research interests
Hospital of Philadelphia.
include cardiovascular tissue engineering, vascular
cell mechanotransduction, cell-cell signaling studies,
cell therapy strategies, and micro and nano-mechanical
devices for biological and biomedical devices. Dr. Lisa
Wise-Faberowski is interested in basic science (in vivo
and in vitro) and clinical investigations evaluating the
effect of anesthetic agents and oxygen on the developing
cyanotic brain. Dr. Robert Wolfe’s research interests are
pulmonary hypertension at altitude, pediatric preventative cardiology, pulmonary vascular hypoxic response,
altitude effects on systemic blood pressure, exercise
physiology (anaerobic threshold), pediatric blood
Wei Tan received the Defense Advanced Research
n
Projects Agency Young Investigator Award.
Cardiology Faculty
Faculty
D. Dunbar Ivy, MD*
Professor of Pediatrics
Section Head, Cardiology
Selby’s Chair in Pediatric Cardiology
Director, Pulmonary Hypertension
Program
Alison L. Ballard, MSN, CPNP
Senior Instructor of Pediatrics
Jean L. Cavanaugh, MS, PA-C
Instructor of Pediatrics
Dennis H. Chang, MD
Instructor of Pediatrics
Jessica C. Church, CPNP
Senior Instructor of Pediatrics
Kathryn K. Collins, MD
Associate Professor of Pediatrics
Director, Pediatric Arrhythmia
Center
Eduardo M. da Cruz, MD
Associate Professor of Pediatrics
Director, Cardiac Intensive Care Unit
2006-2008 Departmental Report
43
sections
Jen Geppner, RN, BSN
Kathleen Miller-Reed, RN, BSN
Laura E. Tucker, RN, MS, CPNP
Stephen R. Daniels, MD, PhD
Professor and Chairman
Department of Pediatrics
University of Colorado Denver School of Medicine
Pediatrician-in-Chief and
L. Joseph Butterfield
Chair in Pediatrics
The Children’s Hospital
Jody E. Rutz, RN, PA-C
Senior Instructor of Pediatrics
K. Scott Kirby
Lead Research Cardiac Sonographer
Timothy Scott, PhD**
Assistant Professor of Pediatrics
Julianne Koehler
Clinical Coordinator of Education
Michael S. Schaffer, MD
Professor of Pediatrics
Medical Director, Outpatient
Operations
John Macheras
Cardiac Sonographer
Bethany A. Diamond, ND, MESS,
RN, CPNP
Instructor of Pediatrics
Elizabeth M. Shaffer, MD
Associate Professor of Pediatrics
Acting Director, Echo Laboratory
Alison M. Artico DuMond, BSN,
MSN, CPNP-AC
Senior Instructor of Pediatrics
Robin Shandas, PhD**
Professor of Pediatrics
Associate Professor of Mechanical
Engineering, CU-Boulder
Director, Cardiovascular Flow and
Imaging Research Laboratory
Director, Cardiovascular Device
Development Laboratory
Director, Center for Bioengineering
Shawn Popylisen
Cardiac Sonographer
Jilayne K. Kloote Smith, RN,
CPNP-AC
Senior Instructor of Pediatrics
Candice Sigur
Cardiac Sonographer
Sharon Downing
Staff Assistant
Lora Stancik
Cardiac Sonographer
Liz Eno
Staff Assistant
Amy Taylor, MS
Beth Gaffney
VP Clinical/ Support Services
Thomas E. Fagan, MD, FACC, FSCAI
Associate Professor of Pediatrics
Director, Catheterization Lab
Mark A. Farina, MS, PA-C
Instructor of Pediatrics
Faith A. Fisher-Halpern, AC-PNP
Instructor of Pediatrics
Brian M. Fonseca, MD
Assistant Professor of Pediatrics
Kendall S. Hunter, PhD**
Assistant Professor of Pediatrics
Jill E. Ibrahim, MD
Senior Instructor of Pediatrics
Director, Pediatric Cardiology
Fellowship Program
C. Denise Kaufholz, RN, MSN, CPNP
Senior Instructor of Pediatrics
Amy R. Stimmler, RN, CPNP
Senior Instructor of Pediatrics
Wei Tan, PhD**
Assistant Professor of Pediatrics
Laura E. Tucker, RN, MS, CPNP
Instructor of Pediatrics
Karrie L. Dyer Villavicencio, MD
Assistant Professor of Pediatrics
Jonathan Kaufman, MD
Assistant Professor of Pediatrics
Carolyn E. Vonderheide, RN, CPNP
Clinical Senior Instructor of
Pediatrics
Joseph D. Kay, MD
Assistant Professor of Pediatrics
Robert R. Wolfe, MD
Professor of Pediatrics
Bruce Landeck, MD
Assistant Professor of Pediatrics
Michael E. Yeager, PhD
Instructor of Pediatrics
Craig J. Lanning, BS**
Senior Professional Research
Assistant
Elizabeth Yeung, MD
Instructor of Pediatrics
Sara M. Mackie, PA-C
Senior Instructor of Pediatrics
Shanna R. Meeks, MS, CPNP- AC
Senior Instructor of Pediatrics
Shelley D. Miyamoto, MD
Assistant Professor of Pediatrics
Director, Heart Failure and
Cardiomyopathy Program
Suzanne M. Osorio-Lujan, DVM
Instructor of Pediatrics
Biagio A. Pietra, MD**
Associate Professor of Pediatrics
Director, Heart Transplantation
Program
Adel K. Younoszai, MD
Assistant Professor of Pediatrics
Clinical Staff
Lori Claussen, RN
Clinical Coordinator of Cardiology
Clinic
Marilyn Day, MS, RD
Jeanine Gruenwald
Lead Cardiac Sonographer
Loreen Gulli, LCSW
Mary Ann Harris, MSW
Lacey Henry
Arrhythmia Coordinator
44 D e p a r t m e n t o f P e d i a t r i c s
Christine Martinez, BS
Meghan Moffat, MSW
Christine Peyton
Clinical Nurse Specialist
Stephanie Seiler
Clinical Coordinator of Cardiac
Pre Post Unit
Heather Shockley
Clinical Coordinator of
Catheterization Lab
Cindy Williams
Cardiac Sonographer
Fellows
Michael Bingler, MD (2007-2009)
Shannon Buckvold, MD (2006-2009)
Jeffrey R. Darst, MD (2005-2008)
Jesse A. Davidson, MD (2008-2011)
Brian M. Fonseca, MD (2007-2008)
Joshua A. Kailin, MD (2008-2011)
Jonathan Kaufman, MD (2005-2006)
Anthony C. McCanta, MD
(2007-2010)
Thomas J. Moon, MD (2008-2011)
Jane E. Nydam, MD (2005-2008)
Christina M. Phelps, MD (2005-2009)
Christopher M. Rausch, MD
(2007-2010)
Joshua J. Sticka, MD (2007-2010)
Cecile Tissot-Daguette, MD
(2006-2008)
Lisa Willis, MD (2006-2009)
Administrative Staff
Michele Boes
Clinical Manager
Shari Borcherding
Staff Assistant and Echo Manager
Linda Brosseau
Staff Assistant
Dawn Christofferson
Systems Administrator
Debbie Coombs
Clinical CIS Coordinator
Kay Cowell
Clinical Manager
Janet Davis
Clinical Director
Kristi Gifford
Staff Assistant
Reggie Henry
Lead Patient Services Coordinator
of Cath Lab
Charlene Holguin
Lead Patient Services Coordinator
of Cardiology Clinic
Desha Mesa
Staff Assistant
Vickie Nelson
Staff Assistant
Renee Patilla
Staff Assistant
Cindi Reid
Staff Assistant
Dawn Schmeck
Business Operations Coordinator
Transplantation Coordinators
Stacey Anderson, MSN, RN, ND
Alison Ballard, MS, CPNP
Carrie Connell, RN, BSN
Bethany Diamond, ND, MESS, RN,
CPNP
Dee Dee Gilbert, RN, BSN
Jilayne Kloote Smith, RN, CPNP-AC
Carrie Vonderheide, RN, CPNP
Samuel Schofield
Database Coordinator
Pulmonary Hypertension Program
Michelle Calderbank, RN, BSN
Aimee Doran, RN, CPNP
**Center for Bioengineering Faculty
Jeanette Starkey
Staff Assistant
* Pediatric Heart Lung Center
Faculty
** Barbara Davis Center for
Childhood Diabetes Faculty
sections
Child Health Associate/
Physician Assistant Program
Clinical Services
The Child HealthAssociate/Physician Assistant Program
(CHA/PA) was established in 1968 in response to a
growing need for pediatric health care providers. It was
the first to offer a master’s degree and remains the only
PA program specializing in pediatrics with service to
disadvantaged, at-risk and medically underserved populations. Although the program offers additional training
in pediatric care, its primary care curriculum prepares
students to evaluate, diagnose, and treat patients of all
ages. For 40 years, CHA/PAs have functioned as colleagues of physicians and other health professionals,
providing comprehensive health services, including not
Child Health Associate/Physician Assistant Program Front row, l - r:
Jonathan Bowser, Jacqueline Sivahop, Anita Glicken, Peggy Munoz,
Laura Casias, Rebecca Maldonado; Back row, l - r: Shannon Gillette,
Cathy Ruff, Celia Kaye, Christina Robohm, Melinda Sogo, Sandra Hoops
only evaluation and treatment of medical disease, but
document that they are an important source of health
also patient education and counseling, anticipatory guid-
care statewide and nationally.
ance and management of behavioral, psychosocial, and
developmental disorders. CHA/PA graduates also serve
Research
as a strong voice for child advocacy in their communities.
The Physician Assistant faculty has received local and
The program has had continuous funding from the
national grants for research and development of physi-
Health Resources Services Administration Bureau of
cian assistant education. This funding has focused on
Health Professions and was the first program at UCD to
the creation and implementation of innovative teaching
receive the Colorado Commission on Higher Education
strategies, including the use of technology.
(CCHE) Award of Excellence. The CCHE award per-
In recent years projects have included: 1) use of
mitted program enhancement and expansion including
standardized patients to longitudinally evaluate student
an innovative Rural Track. The CHA/PA curriculum
knowledge and skill development over three years;
is recognized for excellence and innovation and is con-
2) development and evaluation of an evidence-based
sistently ranked by U.S. News & World Report in the
master’s curriculum; 3) development of a community-
top 10 programs nationally. Problem-based learning,
based adolescent health education learning initiative to
evidenced-based medicine, and an extensive curriculum
enhance recruitment of minority, disadvantaged, and
in developmental, emotional, and behavioral medicine
rural students; 4) development, implementation, and
are successful elements of the curriculum. Clinical expe-
evaluation of a curriculum in primary care for adjudicat-
rience during the first year has been an integral part of
ed adolescents; 5) implementation of an enhanced rural
the CHA/PA Program since inception. In cooperation
track through additional linkages in a rural, underserved
with the Center for Advancing Clinical Excellence, the
area in southwestern Colorado; 6) implementation
program has expanded the use of standardized patients
and evaluation of online problem-based learning and
and clinical skills stations for both education and assess-
evidenced-based medicine curricula through the develop-
ment. The high degree of acceptance of CHA/PAs by
ment of a cross-cultural case of adolescent obesity; and
physicians, health providers, and the public, as well as
7) development, implementation, and evaluation of a
their demonstrated proficiency and cost effectiveness,
new Web-based assessment tool and test bank.
2006-2008 Departmental Report
45
sections
Objectives for currently funded projects include:
1) enhanced recruitment of minority and disadvantaged
graduates serve as leaders in their communities advancing the needs of children and families.
students through the development of a communitybased, health promotion/disease prevention and service/
Highlights
learning initiative, targeting middle-school-age children;
n
U.S News & World Report ranked the CHA/PA
Program eighth in the country out of 143 programs.
2) increased PA student competency in geriatric medicine through the design, implementation, and evaluation
of an enhanced didactic and clinical curriculum in long-
This program is the only pediatric physician assistant
n
program in the country.
term and palliative care; and 3) enhanced cultural competency through the design, implementation, and evaluation of a curriculum addressing the role of spirituality
and religion in patient care.
Anita Glicken, MSW, is interested in curriculum and
faculty development, evidence-based medicine, psychosocial aspects of health care, interprofessional practice,
and assessment. Jonathan Bowser, MS, CHA/PA-C, is
focused on family medicine and curriculum and assessment development. Sandra Hoops, MS, CHA/PA-C,
centers her research on childhood diabetes and standardized patient assessment. Rebecca Maldonado, MS,
PA-C, evaluates curriculum development, physician
assistant education research, and ambulatory pediatrics.
Joyce Nieman, MHS, CHA/PA-C, is interested in adolescent medicine and physician assistant clinical educa-
CHA/PA Faculty
Faculty
Anita D. Glicken, MSW
Professor of Pediatrics
Section Head and Director,
CHA/PA Program
Jonathan M. Bowser, MS, CHA/PA-C
Instructor of Pediatrics
Sandra L. Hoops, MS, CHA/PA-C
Associate Professor of Pediatrics
Rebecca Maldonado, MS, PA-C
Assistant Professor of Pediatrics
Joyce A. Nieman, MHS, CHA/PA-C
Assistant Professor of Pediatrics
Christina M. Robohm, MS, CHA/PA-C
Associate Professor of Pediatrics
Associate Director of Admissions
and Student Life, CHA/PA Program
Cathleen C. Ruff, MS, CHA/PA-C
Assistant Professor of Pediatrics
Associate Director of Curriculum,
CHA/PA Program
Jacqueline Sivahop, MS, PA-C
Instructor of Pediatrics
Clinical Faculty
Sandy Fallon, PA-C
Clinical Instructor of Pediatrics
Raul Gierbolini, DHS
Clinical Instructor of Pediatrics
Celia I. Kaye, MD, PhD
Clinical Professor of Pediatrics
Medical Director, CHA/PA Program
Kyle Tick, LCSW
Clinical Instructor of Pediatrics
tion. Christina Robohm, MS, CHA/PA-C, evaluates
Child Neurology
ambulatory general pediatrics, admissions and recruit-
Clinical Services
ment, and diversity. Cathleen Ruff, MS, CHA/PA-C,
The Section of Child Neurology is nationally recognized
has research interests in pediatric allergy and asthma,
for providing outstanding consultation, clinical care, and
service learning, and rural medicine. Kyle Tick, LSW,
surgery for children and adolescents with neurological
is interested in psychosocial medicine.
disorders. The Section offers comprehensive evaluation
and treatment of neurological disorders, parent, and
Education
patient education, comprehensive neurological consulta-
We are an accredited master’s level physician assistant
tion services, and inpatient and outpatient treatment.
(PA) program with a strong commitment to educating
The team is recognized as a leader in the diagnosis and
and training the next generation of physician assis-
treatment of epilepsy and seizure disorders, headache,
tants to meet the primary health care needs of under-
neuromuscular diseases, movement disorders, pediatric
served communities in Colorado and across the nation.
stroke, and genetic disorders affecting the nervous system.
Consistently rated in the top ten training programs in
Programs are designed to help coordinate the multiple
the country, our innovative three-year curriculum offers
specialists and services required for optimal diagnosis and
outstanding training in primary care across the lifespan
treatment of these illnesses. As the largest academic medi-
as well as special expertise in pediatrics. Faculty and
cal center in the region providing such broad expertise,
46 D e p a r t m e n t o f P e d i a t r i c s
sections
Child Neurology Front row, l - r: Carolyn Green, Kelly Knupp, Amy Brooks-Kayal, Jean Milholland, Jennifer Armstong-Wells, Tonia Sabo-Graham;
Middle row, l - r: Richard Boada, Susan Koh, Greta Wilkening, Holly Briscoe, Dee Daniels, Julie Parsons, Abigail Collins, Pramote Laoprasert,
Scott Turner, Mary Ann Maddox; Back row, l - r: Daniel Arndt, Amanda Sturgil, Jennifer Flack, Paul Levisohn, Timothy Benke, Kristin Park,
Timothy Bernard, Bradford Miller, Paul Moe
Child Neurology at The Children’s Hospital (TCH) is the
Research
referral center for children with neurodevelopmental dis-
Research is an integral part of the Section of Child
orders for much of the western United States.
Neurology and is essential to its mission to advance the
Faculty members are active in translational and
care of children and adolescents with neurological dis-
clinical research in the neurosciences that will lead to
orders now and in the future. Current projects include
improved treatment options for patients with neurological
both clinical and translational neuroscience investiga-
disorders. They are also leaders in numerous national
tions focused on improving the understanding and treat-
and international societies devoted to the treatment
ment of a variety of neurological disorders.
and understanding of pediatric neurological disorders,
TCH in affiliation with the University of Colorado
including the Child Neurology Society, the American
Denver School of Medicine is pioneering research into
Epilepsy Society, the International Pediatric Stroke
some of the newest treatments, latest preventions,
Study, and the Society for Neuroscience.
and most promising cures of childhood diseases. The
The Section of Child Neurology currently has
Anschutz Medical Campus provides opportunities for
30 pediatric faculty members, including physicians,
early-stage and start-up research-oriented biotechnology
neuropsychologists, researchers, and nurse practitioners,
and will facilitate the use of emerging science to pioneer
10 clinical staff, and 7 residents/fellows. The main office
discoveries benefiting global health care. The Section
and the majority of clinics are located at The Children’s
is proud to be a part of this exciting research environ-
Hospital, in Aurora, Colorado. Clinical services are also
ment and to perform cutting-edge research to improve
provided through The Children’s Hospital Network of
treatment opportunities for patients with neurologic
Care centers in Broomfield and Parker and at other sites
disorders. Investigators in the Translational Epilepsy
throughout the region.
Research Program study how seizures develop and
how best to treat them.
2006-2008 Departmental Report
47
sections
Dr. Timothy Benke’s lab studies the function of syn-
epilepsy surgery and as predictors of surgical outcome.
apses, the primary means of communication between
Dr. Susan Koh has interests in epilepsy surgery, tuber-
neurons in the brain. Results are likely to help prevent
ous sclerosis, and the ketogenic diet. Dr. Daniel Arndt
the effects of early-life seizures, which can include learn-
has research interests in post-traumatic epilepsy, epilepsy
ing impairment and epilepsy, and will also advance the
surgery, and traumatic brain injury.
understanding of the synaptic mechanisms underlying
mental retardation. Dr. Amy Brooks-Kayal oversees sev-
Stroke
eral NIH-funded research studies related to epilepsy. Her
Dr. Jennifer Armstrong-Wells is investigating perinatal
research focuses on understanding the molecular and cel-
stroke, childhood hemorrhagic and arterial ischemic
lular mechanisms that result in development of epilepsy
stroke. Dr. Timothy Bernard is researching inflamma-
in order to develop new ways to prevent and treat this
tion, classification, treatments, and outcomes in child-
disorder. Her lab also studies the effects of early-life sei-
hood arterial ischemic stroke. He has recently been
zure activity and seizure treatment on brain development.
awarded the NIH, Colorado Clinical and Translational
Dr. Yogendra Raol’s research focuses on developing new
Sciences Institute K12 grant, entitled, “Markers
treatments for neonatal seizures and identifying EEG
of Inflammatory Coagulopathy and Coagulation
“biomarkers” that will help predict which at-risk chil-
Activation as Predictors of Arteriopathy, Recurrence
dren will develop epilepsy. Dr. Andrew White’s research
and Outcome in Childhood Arterial Ischemic Stroke.”
is in the area of epileptogenesis and neuroprotection.
He is specifically interested in the area of neonatal
Headache
hypoxic-ischemic injury and is experienced with multiple
Dr. Tonia Sabo-Graham has a particular interest in
in vivo monitoring systems including radiotelemetry and
“nutritional neurology,” specifically, investigating the
tethered animal video-EEG systems. Dr. Audrey Yee’s
context of migraine disorders and interrelationships with
research is directed at understanding the basic mechanisms
certain micronutrients. She has extensive experience in
of anticonvulsants and antiepileptogenic compounds and
participating in clinical trials and is currently conducting
the cellular mechanisms of epilepsy.
a protocol sponsored by the TCH Clinical Translational
The Section of Child Neurology participates in and
Research Center and TCH Research Institute inves-
benefits from the latest in clinical trials and other patient
tigating relationships of magnesium, riboflavin, and
studies. Our faculty are currently involved in the following
coenzyme Q10 in children with migraine. Mary Ann
clinical research:
Maddox, PNP, also has research interests in the treatment of headaches.
Epilepsy
Dr. Paul Levisohn is a principal investigator for clinical
Movement Disorders
epilepsy research supported by internal and extramural
Dr. Abigail Collins’ research focuses on a variety of
funding. He is currently conducting clinical trials inves-
pediatric movement disorders. Scott Turner, FNP-C,
tigating childhood absence epilepsy, new antiepileptic
investigates tics and Tourette syndrome.
drugs for use in children, and health-related quality
of life for children with epilepsy and their families.
General Neurology
Dr. Pramote Laoprasert is pursuing clinical research
Dr. Carolyn Green is investigating the comanagement of
related to neuroimaging in patients with epilepsy,
medical homes for children with chronic conditions and
including neuroimaging studies and invasive EEG
improved communication among specialty and primary
monitoring as pre-surgical workups prior to pediatric
care providers. Dr. Paul Moe has explored and published
48 D e p a r t m e n t o f P e d i a t r i c s
sections
on clinical child neurology, including spike wave
Highlights
stupor, infantile polymoclonia-opsoclonus syndrome,
n
Dr. Amy Brooks-Kayal became the new Section Head
and encephalitis. During his many years at TCH,
of Child Neurology and the Ponzio Family Chair in
Dr. Moe has written numerous articles and book
Pediatric Neurology at TCH.
chapters on pediatric neurology.
With many new recruitments to the outstanding exist-
n
ing faculty in Child Neurology, the Section provides
Neuropsychology
world-class expertise in clinical care and research in a
The neuropsychologists within the Section are involved in
broad range of pediatric nervous system disorders.
research regarding the effects of bone marrow transplantation on cognitive development, quality of life, and cognitive
changes associated with brain tumors and their treatment,
as well as cognitive functioning subsequent to surgical
resection for intractable epilepsy. Dr. Greta Wilkening is
interested in the cognitive and perceptual consequences
of neurologic diseases, or the treatments for such diseases. Specific foci include the long-term consequences
of stroke, epilepsy, seizure surgery, and treatment for
neoplastic disease. Dr. Richard Boada is involved in an
NIH-funded longitudinal study of speech and reading
disorders. The research is designed to identify shared
genetic, cognitive, and environmental factors that
explain the comorbidity between phonological disorder
and dyslexia. Dr. Jennifer Janusz has research interests
in the neurocognitive, behavioral, and emotional func-
Child Neurology Faculty
Faculty
Amy R. Brooks-Kayal, MD
Professor of Pediatrics
Section Head, Child Neurology
The Ponzio Family Chair in
Pediatric Neurology
Jennifer Armstrong-Wells,
MD, MPH+
Assistant Professor of Pediatrics
Director, Perinatal and Hemorrhage
Stroke Programs
Daniel Arndt, MD
Instructor of Pediatrics
Timothy A. Benke, MD, PhD
Associate Professor of Pediatrics,
Neurology and Pharmacology
Timothy J. Bernard, MD+
Assistant Professor of Pediatrics
Co-Director, Colorado Pediatric
Stroke Program
+
tioning of children with Neurofibromatosis Type 1.
Richard Boada, PhD
Assistant Professor of Pediatrics
Clinical Neuropsychologist
Education
Holly Briscoe, RN, CPNP
Senior Instructor of Pediatrics
The Section of Child Neurology has a strong commitment
to educating and training the next generation of child neurologists. The faculty teach and mentor fellows, residents,
and medical students. The three-year, ACGME-accredited
residency program in child neurology provides academic,
clinical, and research experiences to residents with previous pediatric training (two years minimum). The pediatric
epilepsy fellowship provides an additional year of training
in epileptology and clinical neurophysiology. The Section
supports the neurology education of pediatric and psychiatry residents through elective rotations and works with
the School of Medicine to provide experiences in pediatric
neurology for third- and fourth-year medical students.
Abigail Collins, MD
Instructor of Pediatrics
Dee A. Daniels, MS, RN, CPNP
Senior Instructor of Pediatrics
Co-Director, Clinical Program
Jennifer Flack, MSN, RN, CPNP
Instructor of Pediatrics
Carolyn L. Green, MD
Associate Professor of Pediatrics
Medical Director
Susan Hines, MSN, RN, CPNP
Senior Instructor of Pediatrics
Jennifer Janusz, PsyD
Assistant Professor of Pediatrics
Clinical Neuropsychologist
Kelly Knupp, MD
Assistant Professor of Pediatrics
Co-Director, Clinical Program
Susan Koh, MD
Associate Professor of Pediatrics
Co-Director, Epilepsy Program
Pediatric Epilepsy Fellowship
Program Director
Pramote Laoprasert, MD
Assistant Professor of Pediatrics
and Neurology
Co-Director, Epilepsy Program
Paul M. Levisohn, MD
Associate Professor of Pediatrics
and Neurology
Mary Anne Maddox, MS, RN, CPNP
Senior Instructor of Pediatrics
Jean Milholland, MS, PA-C+
Instructor of Pediatrics
Bradford R. Miller, MD
Senior Instructor of Pediatrics
Paul G. Moe, MD
Professor of Pediatrics and
Neurology
Kristen Park, MD
Instructor of Pediatrics
Julie A. Parsons, MD
Assistant Professor of Pediatrics
Child Neurology Residency
Program Director
Yogendra Raol, PhD
Assistant Professor of Pediatrics
Tonia M. Sabo-Graham, MD
Assistant Professor of Pediatrics
Amanda Sturgil, RN, MS, CPNP
Instructor of Pediatrics
Scott Turner, MSN, RN, FNP-C
Senior Instructor of Pediatrics
Andrew M. White, MD, PhD
Assistant Professor of Pediatrics
Greta N. Wilkening, PsyD+
Associate Professor of Pediatrics
Clinical Neuropsychologist
Director, Neuropsychology
2006-2008 Departmental Report
49
sections
Audrey S. Yee, MD
Assistant Professor of Pediatrics
Clinical Faculty
Thomas T. Reiley, MD
Associate Clinical Professor
of Pediatrics
Residents and Fellows
Child Neurology Residents
Edward Jernigan, MD (2006-2009)
Cynthia Keator, MD (2008-2011)
Sita Kedia, MD (2007-2010)
Teri Schreiner, MD (2007-2010)
Britt Stroud, MD (2007-2010)
Carter Wray, MD (2006-2009)
Pediatric Epilepsy Fellow
Lucy Zawadzki, MD (2005-2009)
Clinical Staff
Neurology
Sheila Lorimer, RN
Carissa Mann, MA
Peggy Schroeder, RN
Loranda Thunen, RN
Cheryl Wheeler-Walker, RN
Wanda Wofford, RN
Rachel Farney, RN
Martha Coffey, RN
Laura Ross, RN
Neuropsychology
Michelle Kleman, MA, LPC
Developmental Specialist
Malinda Kohne, MA
Developmental Specialist
Administrative Staff
Katherine Griewahn, MBA, MHA
Business Manager
Julie Bell
Database Coordinator
Dusty Christian
Staff Assistant
Kim Mondragon
Staff Assistant
Jacqueline Roberts
Staff Assistant
Tanya Rivera
Staff Assistant
Clinical Genetics and Metabolism Front row, l - r: Michael Woontner,
Stephen Goodman, Elaine Spector, Richard Spritz; Back row, l - r:
Katheleen Gardiner, Frank Frerman, Kenneth Maclean, Karl Pfenninger,
Kimberly Bjugstad
Patricia A. Schmitter, MEd
Residency Coordinator
genetic basis of inherited disorders, both rare and common. In several rare genetic diseases, current research
+
Colorado Pediatric Stroke
Program Faculty
Clinical Genetics and Metabolism
delineates the spectrum of mutations and how they
can predict outcome. Translational research efforts are
bringing these new findings to clinical care through our
service laboratories. Mutagenesis studies review the
impact of environmental variables on producing genetic
Clinical Services
changes. Several of our Section’s large studies involve
The Clinical Genetics and Metabolism Section provides
gene discovery in complex diseases, including various
consultative inpatient services at The Children’s Hospital
autoimmune diseases and cleft lip and palate, one of
(TCH) and affiliated hospitals as well as regional outreach
the most common birth defects. We have organized
programs in genetics in Colorado, Wyoming, and Montana.
VitGene, an international consortium of 38 investigators
Clinics organized and staffed by this Section include gen-
in 20 countries, and are now performing a very large
eral genetics clinic, inherited metabolic diseases (IMD)
genome-wide association study of generalized vitiligo
clinic, and neurofibromatosis/neurocutaneous clinic. The
(one of the most common autoimmune diseases), which
Section also participates in neuromuscular, tuberous scle-
is studying autoimmune thyroid disease in development.
rosis, skeletal dysplasia, growth, ophthalmology, cleft lip
We have also carried out an extensive examination of
and palate, spina bifida, and autism specialty clinics, as
the developmental genetics of facial development in
well as the Bill Daniel’s Center for Children’s Hearing at
the mouse, with the long-term goal of identifying genes
TCH. Clinical laboratories are available for diagnostic
responsible for human facial development that may play
cytogenetics, molecular genetics, and biochemical genetics.
important roles in cleft lip and palate.
For select genetic conditions, we are examining the
Research
mechanisms by which genetic changes lead to clinical
The Section of Clinical Genetics and Metabolism pur-
symptoms. This research involves basic scientific con-
sues clinical and basic research on numerous inherited
cepts, such as mechanisms of neuronal development,
conditions. Research involves the identification of the
and opens the possibility for new therapeutic avenues,
50 D e p a r t m e n t o f P e d i a t r i c s
sections
Syndromes of malformation, specifically skeletal
n
dysplasia, VATER, pigmentation disorders, microdeletion-duplication disorders, cleft lip and palate,
recombinant (8) syndrome
Energy and metabolism disorders including homo-
n
cystinuria, proprionic and methylmalonic acidurias,
phenylketonuria, lysosomal disorders, trimethylaminuria, fatty acid oxidation disorders, multiple
acyl-CoA dehydrogenase deficiency, mitochondrial
disorders, glutaric aciduria type I, disorders of glycine
metabolism, pyridoxine dependent seizures
Clinical Genetics and Metabolism l - r: Cynthia Freehauf,
David Manchester, Laurie Bernstein, Gary Bellus, Janet Thomas,
Chun-Hui (Anne) Tsai, Gunter Scharer, Carol Walton, Johan Van Hove
Multifactorial and multigene disorders, including
n
autoimmune disorders, pigmentation disorders,
genetic ophthalmologic disorders
which we can then further pursue in translational clini-
*Further information about the IDDRC is provided
cal studies. Efforts are under way to explore conditions
under Programs.
as varied as glutaric aciduria type I, homosytinuria due
to cystathionine beta-synthase deficiency, nonketotic
Dr. Gary Bellus is interested in the genetic etiology
hyperglycinemia, mitochondrial liver disorders, and
of skeletal dysplasias and genodermatoses as well as in
Down syndrome. We are performing treatment studies
conducting clinical trials in the treatment of plexiform
that include the use of stem cell treatment for genetic
neurofibromas in patients with neurofibromatosis,
conditions including Down syndrome.
type 1. Laurie Bernstein, MS, RD, FADA’s research
Clinical research in our Section includes studies to
involves the long-term dietary management of metabolic
describe the clinical spectrum of disorders, such as skeletal
disorders. Dr. Kimberly Bjugstad’s research is focused
dysplasias, and studies on comprehensive care, including
on treating Parkinson’s disease and Down syndrome
new treatments for neurofibromatosis, lysosomal storage
using cell replacement or enhancement strategies.
disorders, and phenylketonuria. An extensive regional
Dr. Pei-Wen Chiang is combining DNA diagnosis with
study on the long-term outcome of patients identified
research on genetic diseases including pigmentation
through newborn screening is coordinated by our Section.
diseases, eye diseases, autism, mental retardation, and
The Section is also involved in educational research
several other rare genetic diseases. Dr. Ellen Elias is a
studies on the effectiveness of education in biochemical
leader in the study of the physiological effects of the
and clinical genetics for groups of professionals.
cholesterol deficiency seen in the genetic disorder Smith-
The Intellectual and Developmental Disabilities
Lemli-Opitz Syndrome (SLOS). Dr. Paul Fennessey’s
Research Center (IDDRC)* aids investigators in our
work involves the application of stable isotopes and
Section in research into mental retardation and related
mass spectrometry to clinical questions, with a focus on
conditions. Major areas of research include:
nutrient metabolism and uptake in the developing fetus
Neurodevelopmental disorders, in particular neurofi-
n
and in the newborn. Cynthia Freehauf, RN, MS, CGC’s
bromatosis, tuberous sclerosis, early seizure disorders,
research interests are focused on clinical case studies,
autism, mental retardation, Down syndrome, glutaric
clinical care issues in PKU, and translational research
aciduria type I
in homocystinuria due to cystathionine beta synthase
2006-2008 Departmental Report
51
sections
deficiency. Dr. Frank Frerman researches the structure
and mechanism of mitochondrial electron transfer
proteins and the inherited diseases that affect these
proteins. Dr. Renata Gallagher’s research interests are
the optimal diagnosis and management of children with
inborn errors of metabolism, particularly urea cycle disorders. Dr. Katheleen Gardiner’s work focuses on the
identification of targets for therapeutic intervention
in Down syndrome learning/memory deficits using
molecular, behavioral, and pharmacological analysis
of mouse models combined with computational analysis.
Dr. Stephen Goodman studies the inborn errors of
amino, organic and fatty acid oxidation, with a particu-
Human Medical Genetics Program Front row, l - r: Ying Jin,
Stanca Birlea, Christina Mailloux; Back row, l - r: Paulene Holland,
Sheri Riccardi, Katherine Gowan, Richard Spritz
lar interest in the pathogenesis of striatal degeneration
in glutaric academia type 1. Dr. Hua Jiang’s research
research focus is on the metabolic disorders associated
focuses on the etiopathology of non-alcoholic steato-
with neonatal epilepsy (glycine encephalopathy and
hepatitis (NASH) and epigenetic mechanism in mental
pyridoxine responsive seizures). His secondary research
retardation associated with cystathionine beta synthase-
interest is chromosomal imbalances (microdeletions/
deficient homocystinuria (CBSDH) with a view towards
duplications) causing complex birth defects and/or intel-
the rational design of novel treatments. Dr. Ying Jin’s
lectual and developmental disabilities. His clinical focus
research focuses on the genetics of generalized vitiligo
is genetic disorders associated with abnormal growth.
and associated autoimmune and autoinflammatory dis-
Dr. John Sladek, Jr., is interested in the analysis of brain
eases and the effects of iodine on autoimmune thyroid
repair mechanisms utilizing cell replacement as a poten-
disease. Dr. Jan Kraus is interested in inborn errors of
tial therapy for the progressive motor disabilities associ-
metabolism, homocystinuria, and propionic acidemia
ated with Parkinson’s disease and Down syndrome. His
in particular. Dr. Kenneth Maclean’s research group
recent work with human embryonic stem cells suggests
uses a range of molecular, biochemical, and behavioral
that host brain cells can be protected from further dam-
techniques in conjunction with transgenic and knockout
age by growth factors produced by newly implanted
mouse models to investigate the pathological mechanisms
stem cells. Dr. Elaine Spector is interested in transi-
that underlie the clinical sequelae of cystathionine beta-
tioning research findings in inherited disorders such as
synthase deficient homocystinuria, Down syndrome, and
glutaric acidemia and non-ketotic hyperglycinemia into
Fragile X syndrome. Dr. David Manchester’s research
clinical testing for the disorder. Dr. Richard Spritz
interests include mutagenesis and genotype-phenotype
investigates the genetic and molecular basis of vitiligo
relationships. Dr. Karl Pfenninger’s laboratory studies
and associated autoimmune diseases, albinism and dis-
the fundamental processes of brain development as well
eases of melanocyte biogenesis, and cleft lip and palate.
as disease mechanisms underlying neurodevelopmental
Dr. Johan Van Hove’s research involves the development
disorders. Of particular interest are the control of neu-
of new therapies for genetic metabolic diseases, particu-
ronal network formation and plasticity and the pertur-
larly for diseases of mitochondrial metabolism and
bation of these processes in Down syndrome and cysta-
for neurometabolic diseases such as nonketotic
thionine beta-synthase deficiency. Dr. Gunter Scharer’s
hyperglycinemia.
52 D e p a r t m e n t o f P e d i a t r i c s
sections
Education
The University of Colorado Denver School of Medicine
Department of Pediatrics and The Children’s Hospital
offers a two-year fellowship/residency in genetics. The
goal of the training program is to provide physicians who
have completed at least two years of training in pediatrics, or other primary specialty, with in-depth training in
clinical genetics that will prepare them for certification
by the American Board of Medical Genetics and a career
in clinical or academic medicine. Elective rotations in
clinical genetics and metabolism are available for residents
in all clinical areas. Clinical genetics and metabolism
is an important component of the pediatric clerkship
curriculum for third-year medical students at UCD. Our
faculty provides a lecture in genetics as part of the clerkship’s core lecture series. An elective in birth defects/
genetics is available for fourth-year medical students who
have successfully completed a pediatric clerkship.
Highlights
John Sladek, Jr., received $3 billion for his Stem Cell
n
Grants Program from the Stem Cell Initiative of the
California Institute for Regenerative Medicine.
Stephen Goodman received the Florence Sabin
n
Award, University of Colorado Denver.
Clinical Genetics and Metabolism Faculty
Faculty
Johan L. Van Hove, MD, PhD+
Associate Professor of Pediatrics
Section Head, Clinical Genetics
and Metabolism
Gary A. Bellus, MD, PhD+
Associate Professor of Pediatrics
and Dermatology
Laurie Bernstein, MS, RD, FADA
Assistant Professor of Pediatrics
Kimberly B. Bjugstad, PhD+
Assistant Professor of Pediatrics
Pei-Wen Chiang, PhD
Instructor of Pediatrics
Cynthia L. Freehauf, RN, MS, CGC
Assistant Professor of Pediatrics
Frank E. Frerman, PhD+
Professor of Pediatrics and Cell and Developmental Biology
Professor of Pharmaceutical Sciences, School of Pharmacy
Renata C. Gallagher, MD, PhD+
Assistant Professor of Pediatrics
+
Katheleen Gardiner, PhD Research Professor of Pediatrics
Stephen I. Goodman, MD+
Professor of Pediatrics
Hua Jiang, PhD
Research Associate of Pediatrics
Ellen R. Elias, MD*+
Professor of Pediatrics
+++
Paul V. Fennessey, PhD** Professor of Pediatrics and Pharmacology
Vice Chair, Research
Ying Jin, MD, PhD
Instructor of Pediatrics
Janell Kierstein, MS, CGC
Instructor of Pediatrics
Jan P. Kraus, PhD+
Professor of Pediatrics and Cell
and Developmental Biology
Michael Woontner, PhD+
Assistant Professor of Pediatrics
Kenneth Maclean, PhD+
Assistant Professor of Pediatrics
Fellows
Jaffar M. Alfardan, MD (2006-2008)
Peter Baker, MD (2008-2010)
Katherine Geiersbach, MD
(2005-2007)
Laura Pickler, MD (2005-2007)
Shauna Gulley, MD (2008-2010)
Margarita Saenz, MD (2007-2009)
David K. Manchester, MD+
Professor of Pediatrics and Pharmacology
Director, Regional Services
Jennifer March, MS, CGC
Instructor of Pediatrics
Michael Mesches, PhD
Assistant Clinical Professor
of Pediatrics
Karl H. Pfenninger, MD+
Professor of Pediatrics and Cell and Developmental Biology
Director, Intellectual and
Developmental Disabilities Research Center
Gunter Scharer, MD, PhD+
Assistant Professor of Pediatrics
John R. Sladek, Jr., PhD+
Professor of Pediatrics and Psychiatry
Vice Chancellor for Research, UCD
Elaine B. Spector, PhD+
Professor of Pediatrics
Director, UCD DNA
Diagnostic Laboratory
Richard A. Spritz, MD+
Professor of Pediatrics and
Biochemistry and Molecular Genetics
Professor of Craniofacial Biology, School of Dentistry
Director, Human Medical Genetics Program
Janet M. Stewart, MD
Associate Professor Emerita
of Pediatrics
Eva Sujansky, MD
Clinical Professor of Pediatrics
and Biochemistry and
Molecular Genetics
Janet A. Thomas, MD+
Associate Professor of Pediatrics
Clinical Director, Clinical Genetics
Director, Inherited Metabolic
Diseases Clinic
Chun-Hui (Anne) Tsai, MD, MSc+
Associate Professor of Pediatrics
Carol S. Walton, MS, CGC
Assistant Professor of Pediatrics
Director, Graduate Program
in Genetic Counseling
Research Fellows
Md. Mahiuddin Ahmed, PhD
Daphne Dubach, PhD
Adriana Estrada-Bernal, PhD
Tomas Majtan, PhD
Lucas Sosa, MD, PhD
Xiaolu Sturgeon, PhD
Clinical Staff
Michele Bennett, MS, CGC
Casey Burns, RD
Amy Dameron, MS
Katrina Merrion, MS, CGC
Kristina S. Kocsis, MS, CGC
Kathleen McKelvie, MS, CGC
Sommer Myers, RD
Marisa Raymond, MS, MPH
Cathlin Rice, MS, CGC
Shannon Scrivner, MS, CGC
Melissa Gibbons, MS
Nina Wemmer, MS, CGC
Erica L. Wright, MS, CGC
Administrative Staff
Dolores Rogers
Administrative Assistant III
Martenia (Tina) Combs
Office Clinical Supervisor
Carrie H. John
Administrator
Monica Klava
Staff Assistant II
Theresa Cole
Administrative Assistant II
Mitsuko (Mitsi) Roman
Staff Assistant II
Doreen Hunter
Patient Service Coordinator
* General Academic Pediatrics Faculty
**Children’s Outcomes Research
Program Faculty
Nutrition Faculty
+
TCH Research Institute Faculty
+
Intellectual and Developmental Disabilities Research Center Faculty
+
Dermatology Faculty
+
2006-2008 Departmental Report
53
sections
Community Pediatrics
Clinical Services
The mission of the Section of Community Pediatrics
is to develop, implement, and evaluate new programs
and new models of health care for improving the health
of Colorado’s children (particularly the underserved
children); to assist community providers in providing
a high-quality, cost-effective medical home for all children; and to educate and prepare pediatric trainees in
providing comprehensive health care to the increasingly
diverse and underserved children of Colorado.
Services to support community-based practices
Colorado Children’s Health Care
Access Program (CCHAP)
The mission of this grant-funded, non-profit organization
is to encourage and enable all Colorado primary care
providers to provide a regular, high-quality source of
comprehensive primary care (a medical home) for lowincome and other underserved children and to ensure
that all Colorado children are able to access a medical
home. This non-profit organization develops, sustains,
and evaluates the resources and support systems
for enabling all Colorado pediatricians and family
physicians to devote at least 10% to 20% of their
practice to the health care of these children. For more
information, visit www.cchap.org.
Socio-Cultural Training Program
This is a grant-funded program to provide training for
the providers and staff in all Colorado pediatric and
family practices and for all Colorado pediatric residents
and faculty in the Department of Pediatrics and to
develop the knowledge, skills, and attitudes that will
enable them to provide culturally sensitive and responsive health care for low-income and racially and ethnically diverse families. For more information, visit
www.dimensionsofculture.com.
Community Pediatrics Front Row l - r: Joan Muzzulin, Mary Ann
Whiteside, Lorena Reyes, Erlinda DeLuna; Back row, l-r: Jeff Poole,
Kevin Heckman, Marcia Carteret, Steven Poole, Anita Rich
Pediatric Provider Resource Hotline
and Care Coordination Program
This program assists all Colorado primary care providers with identifying and utilizing all appropriate medical,
psychological, and socio-economic resources and assists
with care coordination to improve health outcomes for
chronically ill children.
Pediatric Locum Tenens Service
This service provides short-term practice coverage
for pediatricians throughout Colorado and Wyoming.
The program emphasizes coverage for rural and small
practices. Over the past 15 years, our physicians have
covered for nearly three-quarters of the pediatric practices in Colorado and Wyoming.
Mini-Sabbatical Program
This is a grant-supported program that provides a weeklong training opportunity at The Children’s Hospital
for pediatricians in rural or small practices. The Locum
Tenens service provides coverage for the community
pediatrician’s practice, while the pediatrician obtains a
self-directed learning experience with various specialties
and programs at TCH.
Community Pediatrics Matters
This site is a Web-based learning community for all
Colorado pediatric primary care providers and residents
54 D e p a r t m e n t o f P e d i a t r i c s
sections
that provides downloadable information, resources, and
the rural health care experience, assisting residents in
case-based training modules on all aspects of culturally
selecting appropriate sites for this month-long rotation
responsive health care, cross-cultural communication,
in their second year. Assistance is also provided to gradu-
and primary pediatric care for underserved children. For
ating residents in preparing a CV, locating potential private
more information, visit www.cchap.org.
practices to join, and navigating the process of selecting,
negotiating with, and entering a private practice if needed.
Research
The Section of Community Pediatrics works closely
Highlights
with the Section of Epidemiology to identify, imple-
Steve Poole received the Judith M. Kaufmann Civic
ment, and evaluate methods of addressing barriers to
Entrepreneurship Award from The Denver Foundation in
care for underserved children in Colorado; provides
recognition for creative methods for improving the health
and evaluates methods for improving the knowledge,
care of underserved children in Colorado.
skills, and attitudes of providers to improve the cultural
responsiveness of their care for ethnic and racial minority families; develops and studies methods for improving
the ability of practices to provide a culturally effective,
coordinated, family-centered, continuously, accessible,
compassionate, and comprehensive medical home for
children; and identifies and evaluates care coordination
resources for children with chronic illness.
Education
The Section has developed a curriculum for pediatric
trainees regarding care in community settings (in preparation for pediatric practice) and care of underserved
children. The Section has also developed a cross-cultural
healthcare curriculum and learning community for both
faculty and residents utilizing workshops, small group
discussions, noon conferences, and a Web site to assist
providers and staff to develop their knowledge base and
skills to provide culturally sensitive and responsive health
care for racial and ethnic minority families. With regard
to residency training, the Section oversees the continuity
practice experience for pediatric residents. Residents spend
an average of a half-day per week over their three years
of residency in a community-based general pediatric
clinic or practice. Half of the residents have their continuity experience in the general pediatric clinic on The
Children’s Hospital campus; one fourth are in the Denver
Health Authority Neighborhood Health Centers; and
one fourth are in private practices. The Section oversees
Community Pediatrics Faculty
Faculty
Steven R. Poole, MD*
Professor of Pediatrics
Section Head, Community
Pediatrics
Vice Chair, Ambulatory and
Community Affairs
Robert Brayden, MD*
Professor of Pediatrics
Research Director
Marcia Carteret, MEd
Instructor of Pediatrics
Director of Cross-Cultural
Health Care
Clinical Faculty
Kathleen Gresh, MD
Clinical Instructor of Pediatrics
Valerie Jacobs, MD
Clinical Instructor of Pediatrics
Thomas J. Wera, MD
Associate Clinical Professor
of Pediatrics
Elizabeth Ann Wuerslin, MD
Assistant Clinical Professor
of Pediatrics
James Doody, PA-C, MSPH
Instructor of Pediatrics
Colorado Children’s Healthcare
Access Program Staff
Erlinda DeLuna, BSW
Social Worker
Tracy Johnson, PhD
Instructor of Pediatrics
Health Policy Analyst
Kevin Heckman, MEd
Administrator, Colorado Children’s
Healthcare Access Program
Barton D. Schmitt, MD*
Professor of Pediatrics
Medical Director, After-Hours
Telephone Care Program
Jeff Poole, BS
Director of Technology
James K. Todd, MD****
Professor of Pediatrics and
Microbiology
Professor of Epidemiology, Colorado
School of Public Health
Section Head, Epidemiology
(Pediatrics)
Vice Chair, Advocacy (Pediatrics)
Jules Amer Chair in Community
Pediatrics
Director, Epidemiology,
Clinical Outcomes and Clinical
Microbiology, The Children’s
Hospital
Lorena Reyes
Resource Coordinator
Anita Rich, MSW
Director of Outreach and Care
Coordination
Mary Ann Whiteside, LLD
Legal Counsel
Administration
Joan Muzzulin
Administrator
* Infectious Diseases Faculty
* Epidemiology Faculty
* General Academic Pediatrics
Faculty
**Children’s Outcomes Research
Program Faculty
2006-2008 Departmental Report
55
sections
Critical Care Medicine
Clinical Services
The clinical mission of the Section of Critical Care
Medicine at The Chilren’s Hospital is to provide the
highest quality of care available to children with single- and multi-organ system failure. Care is provided
via an integrative approach, utilizing the expertise of
pediatric intensivists, anesthesiologists, pulmonologists, cardiologists, and other medical subspecialists, as
well as pediatric and subspecialty surgeons, to provide
the most technologically advanced medical support and
service to the sickest children in the Rocky Mountain
Region. Working in conjunction with the physicians
on a 24 hours a day, 7 days a week basis are a highly
skilled team of nurses, pharmacists, respiratory therapists, nutritionists, and social workers. This integrated
service approach ensures the highest level of service to
Critical Care Medicine Front row, l - r: Dayanand Bagdure, Sarena Teng,
Joseph Albeitz; Middle row, l - r: Melissa Cercone, Eva Grayck,
Peter Mourani, Evgenia Gerasimovskaya, Roopa Thukaram;
Back row, l - r: Carlos Barajas, Dale Brown, Kurt Stenmark, Angela Czaja
all children in the Pediatric Intensive Care Unit (PICU).
Research
Complex therapies including extracorporeal membrane
The research arm of the Section of Critical Care Medicine
oxygenation (ECMO), continuous renal replacement
comprises the Developmental Lung Biology Laboratory
therapies (CRRT), high-frequency oscillatory ventila-
and Cardiovascular Pulmonary (CVP) Research
tion (HFOV), and inhaled nitric oxide (iNO) are avail-
Laboratory at the University of Colorado Denver School
able 24 hours a day, 7 days a week, 365 days a year.
of Medicine (UCDSOM). A large multidisciplinary group
In addition, services and support are provided to active
of investigators from diverse departments within the
and expanding programs in lung, bone marrow, renal
University work to advance the understanding of the
and liver transplantation surgery as well as trauma. The
impact of injury on the developing lung and lung cir-
PICU provides care and support for the region’s only
culation, an area of research that is closely related to
Pediatric Level 1 Trauma program. The Section also
problems encountered on a daily basis in the PICU.
operates state-of-the-art research programs in the basic
In addition, work specifically examining the effects of
and clinical sciences to provide the cutting-edge ideas
hypoxia on many organ systems is performed. This is
and technology necessary to advance the field of pediat-
especially relevant given the many hypoxia-related prob-
ric critical care and to provide the latest and most inno-
lems encountered by residents or visitors to the Rocky
vative care to our patients. Active subspecialty training
Mountain Region.
programs in critical care medicine, pulmonary medicine,
The research work includes studies at the basic
cardiology, and general and cardiovascular surgery also
molecular and cellular levels, as well as translational
allow the Section the opportunity to help train the next
biology and physiology studies. The laboratory receives
generation of pediatric critical care physicians, as well as
substantial funding from the NIH, the American Heart
to provide a round-the-clock presence of highly qualified
Association, and the American Lung Association.
clinicians in the PICU.
This investigative group is multidisciplinary and composed of full-time MD and PhD researchers from the
Section of Critical Care Medicine, as well as clinicians/
56 D e p a r t m e n t o f P e d i a t r i c s
sections
scientists from other divisions within the Departments of
ing lung injury and restoring vascular and lung growth
Pediatrics, Medicine, and Anesthesiology at UCDSOM.
and by examining animal models for new approaches to
In addition, close affiliations and collaborations are
ameliorating perinatal lung injury and restoring vascular
ongoing with investigators at both the Department of
and lung growth. Two clinical and two basic projects
Physiology and the School of Veterinary Medicine at
address these objectives. The clinical projects evaluate
Colorado State University.
(1) the impact of inhaled nitric oxide (iNO) on BPD,
A program project grant, which is the centerpiece of
and (2) the development of improved techniques to
the Cardiovascular Pulmonary Research Laboratory,
assess the presence of pulmonary hypertension and the
comprises four scientific projects focused on studies of
responses to therapy in infants with pulmonary hyper-
the mechanisms of hypoxic pulmonary hypertension
tension. The two basic projects dissect the mechanisms
(PH). The proposed studies are collectively founded
contributing to lung vascular remodeling in murine,
on the hypothesis that the pathogenesis of hypoxic PH
rodent, ovine, and bovine models and evaluate the
involves both functional (vasoconstriction and wall
effects of novel pharmacologic agents on lung vascular
stiffening) and structural (vascular wall thickening) com-
disease in these models. Collaborative interactions with
ponents, and that both components involve hypoxia-
National Jewish Health, the Center for Bioengineering,
induced alterations in resident cell function as well as
and the Sections of Pulmonology, Neonatology, and
recruitment and interactions with inflammatory and/or
Cardiology drive this program forward.
progenitor cells. Four highly collaborative and interac-
Dr. Joseph Albietz’s research work is focused on the
tive projects will provide new insights into the cellular/
description of the mechanisms underlying the compensa-
molecular mechanisms of chronic hypoxic pulmonary
tory and deleterious effects of pulmonary hypertension
vasoconstriction and vascular stiffening and remodel-
on the proximal arteries of the pulmonary circulation and
ing and may lead to novel, more effective therapy for
right ventricle in children. Dr. Robert Dale Brown’s
hypoxic PH. The basic work is supported by two major
research focus is on inflammatory and fibrotic remodel-
Core facilities. One provides the facilities to expose
ing of the right heart in cardiopulmonary disease.
animals (mice, rats, calves, and humans) to acute and
Dr. Todd Carpenter’s research interests include altitude-
chronic hypobaric hypoxia. In addition, state-of-the-art
related illness in children and the effects of viral infec-
equipment is provided for hemodynamic assessments of
tions on the pulmonary vasculature and lung fluid
the pulmonary and systemic circulations. A large Cell
balance. Dr. Angela Czaja’s research interest is in the
Culture and Histopathology Core also supports the sci-
outcomes of critically ill children with severe influenza
entific projects.
infection in the PICU, in addition to PTSD among pedi-
In the Developmental Lung Biology Laboratory,
atric critical care nurses. Dr. Mita Das’s current research
which works cooperatively with the Pediatric Heart
investigates the mechanisms by which hypoxia alters
Lung Center, directed by Dr. Steven Abman, research
proliferative responses and signaling mechanisms present
work is focused on determining mechanisms involved in
in the adventitial fibroblast. Dr. Emily Dobyns’ research
lung vascular growth. The centerpiece for the laboratory
efforts are primarily directed towards clinical studies of
is a Specialized Centers of Clinically Oriented Research
novel therapies for pediatric acute respiratory failure.
(SCCOR) Program. The SCCOR Program generates
Dr. Maria Frid studies the role of bone marrow-derived
clinical and basic information that will provide insight
inflammatory and progenitor cells in pulmonary vascu-
into the mechanisms contributing to the pulmonary vas-
lar remodeling. She investigates the mechanisms leading
cular abnormalities that characterize BPD. This is done
to the recruitment, retention, and differentiation of stem
by evaluating current available therapies aimed at reduc-
or progenitor cells in the lung and lung circulation.
2006-2008 Departmental Report
57
sections
Dr. Evgenia Gerasimovskaya’s research interests include
care medicine and the conduct of biomedical research
purinergic signaling pathways in vascular cells, molecu-
related to pediatric critical care. Emphasis is placed on
lar mechanisms of hypoxia-induced ATP (adenosine
the stabilization and management of the critically ill
triphosphate) release, and metabolism of extracellular
child with acute single or multisystem organ failure due
ATP by ecto-nucleotidases. She also investigates the
to cardiac, pulmonary, infectious, neurologic, or trau-
mechanisms of hypoxic activation of heterotrimeric
matic illness. The PICU serves active programs in pediat-
G proteins, intracellular kinases, as well as Egr-1 tran-
ric cardiac surgery, general surgery, trauma surgery, and
scription factor. Dr. Eva Grayck is the Director of the
bone marrow and solid organ transplantation. Critical
Pediatric Critical Care Fellowship Program and has an
care fellows participate actively in the multidisciplinary
active laboratory studying the role of reactive oxygen
teams responsible for the care of those patients, includ-
species and antioxidants in the pathogenesis of pediatric
ing the medical PICU team and a dedicated cardiac ICU
pulmonary hypertension. She is interested in the function
team. Numerous research opportunities are available
of reactive oxygen species as signaling molecules that
and fellow research is supervised by one or more of our
regulate key transcription factors and their downstream
faculty members. NIH-funded research programs are
targets and in the application of novel antioxidant strat-
available in pulmonary vascular disease, oxygen radical-
egies to treat animal models of BPD and pulmonary
induced organ injury, mechanisms of airway reactivity,
hypertension. Dr. Peter Mourani is fellowship-trained
interstitial lung disease, and perinatal metabolism.
in both pediatric intensive care medicine and pediatric
Pediatric Residents rotate through the Pediatric
pulmonology. His research work centers on the dif-
Intensive Care Unit (PICU) and are exposed to a diverse
ferences in gene expression pattern between fetal and
patient population, both culturally and medically.
adult vascular smooth muscle cells. Dr. Kurt Stenmark
Residents are actively involved in the management of
is the Director of the Developmental Lung Biology
each patient and are thereby exposed not only to the
Laboratory at UCDSOM. As the principal investigator
basic principles of pediatric critical care medicine, but
of a Specialized Centers of Clinically Oriented Research
also to the use of cutting-edge therapies in the care of
(SCCOR) grant from the NIH, Dr. Stenmark leads a
the critically ill child. Half of the admissions to the
group investigating the basic cellular and molecular
PICU are surgical and half are medical, which provides
mechanisms involved in the response of the developing
a diverse training opportunity.
lung vasculature to hypoxia and other injuries, primarily
BPD. Dr. Stenmark also directs a program project grant
Highlights
entitled “Adaptations to Hypoxia” in which a large
n
The SCCOR program entitled “Lung Vascular
group of investigators examine the molecular mecha-
Diseases in Infants and Children: Mechanisms and
nisms through which chronic hypoxia elicits changes in
Treatment” was one of only two programs funded in
the structure and function of lung blood vessels.
the U.S. to study pediatric pulmonary hypertension.
The Section is recognized as one of the top pediatric
n
Education
critical care research programs nationally, with one
The Section of Critical Care Medicine and the
of the highest levels of extramural funding within a
Department of Pediatrics offer a fully accredited pedi-
critical care section.
atric critical care fellowship designed for board-eligible
The Section is actively involved in national efforts to
n
pediatricians planning a career devoted to the care of the
improve patient safety and promote quality improve-
critically ill child. This fellowship program offers broad-
ment in the pediatric intensive care unit.
based training in both the practice of pediatric critical
58 D e p a r t m e n t o f P e d i a t r i c s
sections
Critical Care Medicine Faculty
Faculty
Kurt R. Stenmark, MD
Professor of Pediatrics
Section Head, Critical Care Medicine
Director, Developmental Lung
Biology and Cardiovascular
Pulmonary Research Laboratories
Eva N. Grayck, MD
Associate Professor of Pediatrics
Director, Pediatric Critical Care
Fellowship Program
Joseph A. Albietz, MD
Assistant Professor of Pediatrics
Postdoctoral Fellows
Adil Anwar, PhD
Anthony J. Greco, PhD
Marina Lewis, PhD
Derek Strassheim, PhD
Claudia B. Kunrath, MD**
Instructor of Pediatrics
Todd C. Carpenter, MD
Associate Professor of Pediatrics
Peter M. Mourani, MD*
Assistant Professor of Pediatrics
Maria G. Frid, PhD
Instructor of Pediatrics
Fellows
Joseph Albietz, MD (2005-2008)
Dayanand Bagdure, MD (2008-2009)
Carlos Barajas, MD (2008-2009)
Grant Burton, MD (2006-2009)
Melissa Cercone, MD (2007-2009)
Margaret Clarke, MD (2006-2009)
Eric Exelbert, MD (2005-2006)
Amelia Hopkins, MD (2005-2007)
Claudia B. Kunrath, MD (2005-2008)
Sarena Teng, MD (2007-2009)
Roopa Thukaram, MD (2006-2009)
Livia Veress, MD (2005-2007)
Evgenia V. Gerasimovskaya, PhD
Assistant Professor of Pediatrics
* Pediatric Heart Lung Center
Angela S. Czaja, MD
Assistant Professor of Pediatrics
Mita Das, PhD
Assistant Professor of Pediatrics
Emily L. Dobyns, MD
Associate Professor of Pediatrics
Medical Director, Pediatric Intensive
Care Unit
Faculty
**Denver Health Faculty
Dermatology
Dermatology l - r: H. Alan Arbuckle, Lori Prok, Joseph Morelli,
Joanna Burch, Arelis Burgos
also provided at The Children’s Hospital North Campus
in Broomfield, and Care by The Children’s Hospital in
Littleton, Parker, and Lutheran/Wheat Ridge, Colorado.
Research
Research in the Section of Dermatology has focused on
sun protection in childhood; the role of sun exposure and
phenotype in the development of moles in childhood;
Clinical Services
improving outcomes for laser treatment of vascular
The Section of Dermatology is the only comprehensive
lesions; developing expertise in the clinical management
pediatric dermatology evaluation and management pro-
of rare vascular lesions; and understanding the etiology of
gram in the Rocky Mountain area. In addition to gen-
congenital melanocytic nevi and neurocutaneous melanosis.
eral pediatric dermatology, multiple other services are
Over the last two years we have added three new
offered including laser therapy of vascular birthmarks
faculty members and markedly increased our research
and other vascular conditions, pediatric dermatologic
efforts. These now include wound healing in epidermo-
surgery, hyperhidrosis evaluation, and treatment includ-
lysis bullosa and other chronic non-healing wounds of
ing iontophoresis, phototherapy with narrowband UVB,
childhood; the increasing incidence and decreasing age
UVA-1, and PUVA, and contact dermatitis evaluation
of onychomycosis; improving outcomes in morphea and
and treatment. There are specialty clinics for epidermo-
adolescent hyperhidrosis; predicting chronicity and sys-
lysis bullosa, wound healing, and vascular malforma-
temic involvment in mastocystosis; and differentiation of
tions. We also have the only dermatopathologist special-
Spitz nevi from melanoma.
izing in pediatric dermatopathology. Clinical services
Dr. H. Alan Arbuckle’s research interests include
for general pediatric dermatology clinics and pediatric
adult and pediatric epidermolysis bullosa and pediatric
subspecialty clinics with Drs. Morelli, Burch, Burgos,
wound care. Dr. Joanna Burch is developing clinical
Arbuckle, and Prok are provided at The Children’s
and research expertise in laser and surgery, and her
Hospital (TCH) in Aurora. Dermatology services are
area of clinical and research interest is congenital nevi.
2006-2008 Departmental Report
59
sections
Dr. Arelis Burgos is conducting a natural history study
of solitary mastocytomas and urticaria pigmentosa,
a prospective study of the risk of glaucoma in facial
port wine stains, and a prospective study on the
efficacy of UVA-1 in plaque type and linear morphea.
Dr. Joseph Morelli’s research interests include hemangiomas, birthmarks, laser surgery, nevi development,
photobiology, eicosanoid metabolism, vitiligo, melanocyte biology, and general pediatric dermatology. He is
Dermatology Faculty
Faculty
Joseph G. Morelli, MD
Professor of Dermatology
and Pediatrics
Section Head, Dermatology
H. Alan Arbuckle, MD
Assistant Professor of Dermatology
and Pediatrics
Gary A. Bellus, MD, PhD+
Associate Professor of Pediatrics
and Dermatology
also involved in the research of skin cancer prevention
for children. Dr. Lori Prok’s research interests include
pediatric dermatopathology, spitz nevi, and mast
cell disorders.
Joanna M. Burch, MD
Assistant Professor of Dermatology
and Pediatrics
Arelis Burgos, MD
Assistant Professor of Dermatology
and Pediatrics
Lori D. Prok, MD
Assistant Professor of Dermatology
and Pediatrics
+
Clinical Genetics and
Metabolism Faculty
Developmental and
Behavioral Pediatrics
Clinical Services
Education
The Section of Developmental Behavioral Pediatrics
Dermatology offers a one- or two-year postgraduate fel-
is comprised of faculty from the Child Development
lowship designed for the individual who has completed
Unit (CDU) at The Children’s Hospital who evaluate
three years of dermatology residency training to develop
and manage children with a variety of developmental
additional clinical and academic skills in pediatric der-
and neurobehavioral differences. We provide single-
matology. The trainee will spend eight half-days per
specialty evaluations as well as interdisciplinary team
week in pediatric dermatology clinics and special clinics,
evaluations for children with developmental and
such as vascular malformation clinic and genetic skin dis-
behavioral concerns from birth through adolescence.
eases clinic at TCH. Genetic skin diseases clinics include
The CDU has four developmental and behavioral
monthly special clinics for epidermolysis bullosa, ich-
pediatricians, a pediatric nurse practitioner, and
thyosis, keratinizing disorders, and pigmentary disorders.
six licensed clinical psychologists who specialize in
Dermatology also offers clinical and research electives
developmental disorders such as intellectual disabilities,
to third- and fourth-year medical students at UCDSOM;
autism, learning disabilities, and attention deficit
and many pediatric residents complete a one-month
hyperactivity disorder. We have established new clinics
rotation at our dermatology clinics.
in the past two years which serve unique needs in our
community. We were awarded a grant from Autism
Highlights
Joseph Morelli was named Chief of Dermatology at
n
The Children’s Hospital.
The Section of Dermatology is the only comprehen-
n
Speaks to become an Autism Treatment Network site
in January 2008. We are part of a multisite network
of 15 programs dedicated to improving medical care
for children with autism spectrum disorders (ASD).
sive pediatric dermatology evaluation and manage-
We have established collaborations with genetics,
ment program in the Rocky Mountain area.
neurology, gastroenterology, and sleep medicine in order
Over the last two years we have added three new
n
to provide more integrated care for children with ASD.
faculty members – Drs. Arbuckle, Burgos, and Prok –
The eXtraordinarY Kids Clinic addresses the medical,
and have markedly increased our research efforts.
endocrine, developmental, and psychological needs of
Lori Prok is the only dermatopathologist specializing
n
in pediatric dermatopathology in the region.
60 D e p a r t m e n t o f P e d i a t r i c s
children and adolescents with X and Y chromosome
variations. We are a member of the National Fragile
sections
the next year we will begin two new studies in collaboration with four other sites as part of ATN: one study
will evaluate nutrition in children with ASD, and one
will compare two methods of education about sleep
hygiene in children with ASD. We also participate in a
multisite, case-cohort study of the etiology of autism,
which is funded by the CDC. The eXtraordinarY Kids
Clinic has a grant to evaluate genotype-phenotype correlations in individuals with sex chromosome aneuploidy
and will establish a repository of DNA for future genetic
studies. We will also study the behavioral and motor
effects of testosterone replacement therapy in adolescent
Developmental and Behavioral Pediatrics Front row, l - r:
Nicole Tartaglia, Samantha Piper, Terry Katz; Middle row, l - r: Ann
Reynolds, Susan Howell, Elizabeth Bennett, Mary Murphy; Back row,
l - r: Emily Werner, Rebecca Wilson, Jennifer Epstein, William Campbell
males with XXY and XXYY syndromes. We are a member of the National Fragile X Foundation’s Fragile X
Clinical and Research Consortium, which was recently
funded by the CDC to develop a registry of subjects
X Foundation’s Fragile X Clinical and Research
with Fragile X for the purpose of tracking medical and
Consortium. The Fragile X Clinic specializes in treating
behavioral features and to facilitate future clinical tri-
individuals with Fragile X syndrome. La Clinica EspaГ±ola
als. Drs. Reynolds and Tartaglia are also members of
is a recently developed multidisciplinary clinic for
the Intellectual and Developmental Disabilities Research
monolingual Spanish speakers. Our LAUNCH program
Center (IDDRC) faculty.
is a short-term program designed to educate and empower
Dr. William Campbell has interests in early identifica-
the parents of children recently diagnosed with autism.
tion, diagnosis, and treatment of developmental disor-
It includes four seminars focused on providing parents
ders, particularly autism and related disorders. He
with effective strategies for helping their child while
serves as medical consultant for Early Intervention
establishing connections for treatment with providers
Colorado within the Colorado Department of Human
in the community. Our programs are designed to help
Services, Division for Developmental Disabilities.
families understand their child’s strengths, identify
Dr. Edward Goldson has interests in the clinical care
areas of developmental concerns, and find appropriate
of children with special health care needs. His research
interventions that will help their child reach his or her
focus most recently has been in the area of autism and
maximum potential.
Down syndrome. In the past, although these are continued interests, he has done work in Fragile X and
Research
newborn follow-up. Dr. Ann Reynolds has interests in
The CDU was awarded a grant by Autism Speaks to
research related to sleep, nutrition, and gastrointestinal
become an Autism Treatment Network (ATN) site in
disorders in children with autism spectrum disorders.
January 2008. We are part of a multisite network of
Dr. Nicole Tartaglia has ongoing research projects
fifteen programs dedicated to improving medical care
addressing the clinical phenotype of children with sex
for children with autism spectrum disorders (ASD). As
chromosome variations and will begin a project in the
part of the ATN, our patients with ASD are eligible to
next year to evaluate the impact of testosterone replace-
be entered into a registry designed to track co-occurring
ment on executive function and behavior in individuals
medical and psychiatric conditions and treatments. Over
with Klinefelter’s syndrome.
2006-2008 Departmental Report
61
sections
Education
We have a strong commitment to educating and training
individuals who will work with children with develop-
Developmental Biology
Program Overview
The Section of Developmental Biology provides insight
mental and behavioral disorders. Our faculty teach and
into the underlying causes of human birth defects
mentor pediatric, neurology, psychiatry, and dentistry
and diseases through basic scientific research. Lee
residents, medical students, psychology interns, and
Niswander, PhD, moved from Memorial Sloan-Kettering
postdoctoral trainees. We provide specialized learning
Cancer Center in New York City to head the new
opportunities in developmental and behavioral pediat-
Section in 2004. Along with Dr. Lee Niswander, the
rics. Some of our faculty participate in the Leadership
Section includes the research groups of Bruce Appel,
Education in Neurodevelopmental Disabilities (LEND)
PhD, and Lori Sussel, PhD. Dr. Appel moved from
program through JFK Partners, which trains leaders in
Vanderbilt University in 2008, and he is the recipi-
the field of developmental disabilities.
ent of the newly endowed Dianne G. Wallach Chair in
Pediatric Stem Cell Biology. The current emphasis is on
Highlights
understanding the normal developmental processes that
Nicole Tartaglia recently established the XtraordinarY
regulate the formation of the pancreas, limb, lung, and
Kids Clinic, a multidisciplinary clinic that addresses the
the spinal cord and brain. Moreover, these research-
medical, endocrine, developmental, and psychological
ers are creating mouse and zebrafish models of genetic
needs of children and adolescents with XXY (Klinefelter
defects to determine why these developmental processes
syndrome), XXYY, Triple X, XYY, and other X and Y
go awry in children born with birth defects (such as
chromosome variations.
spina bifida) or who later develop diabetes.
Developmental and Behavioral Pediatrics Faculty
Faculty
Sandra L. Friedman, MD, MPH
Associate Professor of Pediatrics
Section Head, Developmental
and Behavioral Pediatrics
Harriet Austin, PhD++
Instructor of Pediatrics
Coordinator, Autism
Treatment Network
William M. Campbell, MD
Assistant Professor of Pediatrics
Edward J. Goldson, MD+
Professor of Pediatrics
Terry F. Katz, PhD++++
Instructor of Pediatrics
Mary Murphy, PhD, CPNP
Senior Instructor of Pediatrics
and Assistant Clinical Professor
of Nursing
Ann M. Reynolds, MD+++
Assistant Professor of Pediatrics
Director, Child Development Unit
+
Nicole R. Tartaglia, MD
Assistant Professor of Pediatrics
Clinical Faculty
Jennifer Epstein, PsyD
Clinical Instructor of Pediatrics
Lead Psychologist
Research
Pamela McKenzie, MD
Associate Clinical Professor
of Pediatrics
The Children’s Hospital Research Institute and was
Staff
Elizabeth Bennett, PhD
Licensed Clinical Psychologist
Susan Howell, MS, MBA
Genetics Counselor
Coordinator, XtraordinaY Kids
Clinic and Fragile X Clinical
and Research Consortium
The Section of Developmental Biology was a new
initiative that originated in 2004 through support of
significantly expanded in 2008 through a gift from the
Gates Frontier Fund. Grants from both public (NIH)
and private foundations (Howard Hughes Medical
Institute, Juvenile Diabetes Research Foundation, Sander
Program for Asthma Research) have helped to support
the research programs of the faculty within the Section.
Research into birth defects and childhood diseases uti-
Samantha Piper, PhD
Licensed Clinical Psychologist
lizes animal models that have been created in the Section
Emily Werner, PhD
Licensed Clinical Psychologist
regulate normal development. Sophisticated micros-
Rebecca Wilson, PsyD
Licensed Clinical Psychologist
+
Intellectual and Developmental
Disabilities Research Center Faculty
+
Kempe Children’s Center Faculty
++
The Children’s Hospital Sleep
Center Faculty
++
JFK Partners Faculty
62 D e p a r t m e n t o f P e d i a t r i c s
to elucidate the molecular and cellular processes that
copy equipment that has been obtained by the Section
provides new insight by allowing the visualization
of dynamic developmental processes. Collaborations
with other groups at The Children’s Hospital and
The University of Colorado Denver, as well as groups
around the nation, have enhanced our ability to
sections
Developmental Biology Front row, l - r: Christina Pyrgaki, Claire Tsai;
Middle row, l - r: Amber Marean, Lee Niswander, Ying Zhang,
Angie Minic, Virginia Bleu Knight; Back row, l - r: Gartz Hanson,
David McKean, Ajay Thomas, Carsten Schnatwinkel
Developmental Biology l - r: Bruce Appel, Julia Zinder, Norio Takada,
Christina Kearns, Timothy Simmons, Melissa Langworthy, Sarah Casper
pinpoint mutant genes, to generate new animal models,
ate fellows (PhD and MD). Our faculty teach graduate
to identify the complex group of molecules that are
and medical school classes, and we provide in-depth and
made in specific cells, and to screen for chemicals of
long-term hands-on training in basic science research.
potential therapeutic importance.
Dr. Bruce Appel’s long-term interests are to identify
genes that are targets for therapies to treat developmen-
Highlights
Bruce Appel is the first recipient of the Diane G.
n
Wallach Chair in Pediatric Stem Cell Biology.
tal, degenerative, and cancerous diseases of the nervous
system. He uses zebrafish as a model system to under-
Lee Niswander presented two notable lectures: the
n
stand the mechanisms that produce and maintain neural
Harvey Lecture at Rockefeller University and the Marine
precursors and that direct the formation of distinct neu-
Biological Laboratories’ Friday Evening Lecture.
rons and glia. Dr. Lee Niswander’s work focuses on the
development of the limb and lung and on closure of the
neural tube. Her work revolves around creating mouse
models to determine the genetic mutations that affect
these developmental processes and to study the potential
of new therapies. Dr. Lori Sussel is recognized for her
research into pancreas development and juvenile diabetes. She has created a number of mouse models to study
the key genes that regulate pancreas development. These
mice also provide important insight into the alterations
that underlie the onset and progression of diabetes.
Education
We have a strong commitment to the education and training of graduate students (PhD and MSTP) and postgradu-
Lee Niswander is Associate Director of the Graduate
n
Program in Biomedical Sciences, UCD.
Developmental Biology Faculty
Faculty
Lee Niswander, PhD+
Professor of Pediatrics and Cell
Biology and Genetics
Section Head, Developmental
Biology
Investigator, Howard Hughes
Medical Institute
Bruce Appel, PhD+
Associate Professor of Pediatrics
Diane G. Wallach Chair in
Pediatric Stem Cell Biology
Director, Pediatric Stem Cell Biology
Lori Sussel, PhD
Associate Professor of Biochemistry
and Molecular Genetics and
Pediatrics
Postdoctoral Research Fellows
Ferogh Ahmadi, PhD (2006-2007)
Maria Barna, PhD (2006-2007)
Christina Chao, PhD (2007)
Jianfu Jeff Chen, PhD (2008)
Kimberly Decker, PhD (2006)
Michelle Doyle, PhD (2006)
Jessica Goodman, MD (2006-2007)
Martin Hanson, PhD (2006-2008)
Tae-Hee Kim, PhD (2007)
Sarah Kucenas, PhD (2008)
Melissa Langworthy, PhD (2008)
Teresa Mastracci, PhD (2007)
Hae-Chul Park, PhD (2008)
Carsten Schnatwinkel, PhD
(2006-2008)
Karen Sears, PhD (2006-2007)
Norio Takada, PhD (2008)
2006-2008 Departmental Report
63
sections
Scott Weatherbee, PhD (2006-2007)
Lei Zhang, PhD (2006-2007)
Irene Zohn, PhD (2006)
Tanya McNeal, BS
Professional Research Assistant
Research Staff
Keith Anderson, BS
Angela Minic, MS
Professional Research Assistant
Lori Bulwith, BS
Professional Research Assistant
Christina Pyrgaki, MS
Sarah Casper, BS
Professional Research Assistant
Jonathon Hill, BS
Christina Kearns, BS
Professional Research Assistant
Vincent Miller, BS
Randolph Roberts, BS
Jessica Schrunk, BS
Jimann Shin, MS
Tim Simmons, BS
Julia Snyder, BS
Brandon Kirby, BS
Ying Zhang, BS
Virginia Bleu Knight, MS
Denise Zannino, BS
Amber Marean, BS
+
Karen McFarland, BS
David McKean, MS
Intellectual and Developmental
Disabilities Research Center Faculty
Emergency Medicine
Emergency Medicine Front row, l - r: Eric Tham, Louis Hampers,
Joseph Wathen, Lalit Bajaj; Middle row, l - r: Maria Mandt, Erika Sidney,
Julieann Tibbetts, Tien Vu, Lara Rappaport, Jennifer Schaeffer;
Back row, l - r: Alison Brent, Catherine Orendac, Genie Roosevelt,
Shirley McKenzie
Clinical Services
The Emergency Medicine Department serves as the
free-standing centers as well as several community hos-
region’s only Level I Regional Pediatric Trauma Center,
pital partners.
delivering high-quality emergent and urgent care 24
The faculty is responsible for the direction of
hours a day, 7 days a week to an enormous geographic
Centura/Flight For Life pediatric transports and pro-
area that extends beyond Colorado to Wyoming,
vides 24 hours a day, 7 days a week phone consultation
Montana, South Dakota, Nebraska, Kansas, and New
to primary care providers and emergency departments
Mexico. The full-time emergency medicine faculty
throughout the region.
members are all board certified in pediatric emergency
Faculty are members of the Colorado State Trauma
medicine and provide care for a wide array of medical,
and Emergency Medicine Advisory Council and the Mile
surgical, and traumatic conditions.
High Regional Trauma and Advisory Council. They are
The faculty is also responsible for The Children’s
also actively involved in the program development and
Hospital community-based Network of Care, provid-
education of prehospital care providers. They provide
ing medical direction and clinical coverage in several of
TCH house-wide Mock COR program and administrate
the community sites beyond our main campus, includ-
the TCH Pediatric Advanced Life Support program.
ing 24 hours a day, 7 days a week urgent/emergent
They are actively involved in regional injury prevention
care at The Children’s Hospital North Campus, The
and child advocacy, including the medical direction of
Children’s Hospital at Parker Adventist Hospital, The
the Kiwanis Pediatric Trauma Institute and regional
Children’s Hospital at Saint Joseph Hospital, and after-
disaster preparedness.
hours urgent care at Care by The Children’s Hospital
at Lutheran (Wheat Ridge) and Children’s After-Hours
Research
Care at Littleton Adventist Hospital. This model allows
Research among the faculty reflects a wide variety of
us to bring pediatric expertise in the emergent manage-
clinical interests. The significant prevalence of pediatric
ment of many conditions directly into well-equipped,
trauma patients has led to projects in injury prevention,
64 D e p a r t m e n t o f P e d i a t r i c s
sections
such as the evaluation of child safety in vehicles in the
interested in medical education, toxicology, and pediatric
rural areas of Colorado and the development and sup-
procedural sedation and analgesia. Dr. Maria Mandt’s
port of child passenger safety initiatives. The epide-
research interests include pre-hospital care, capnography,
miology of traumatic injuries at our Pediatric Level 1
and pediatric procedural sedation. Dr. Lara Rappaport
Trauma Center is being compared with that of other
is involved with pre-hospital care, capnography/airway
institutions. Large numbers of trauma patients have also
management, and laryngeal mask airways. Dr. Arleta
resulted in studies of the appropriate and best use of
Rewers’s research interests include acute complications
sedation and analgesia as well as regional nerve blocks
of diabetes and epidemiological injury and prevention.
for orthopedic injuries and painful procedures.
Dr. Genie Roosevelt is involved with asthma, alternative
Common respiratory illnesses are under investigation
care settings including the short stay unit, and predictors
through the study of outpatient home oxygen therapy
of hospitalization rates and length of stay. Dr. Erika
for patients with bronchiolitis, the utilization of chest
Sidney’s research interests include head injury, head CT
radiographs in first-time wheezing episodes, and the best
scans, and physician decision-making. Dr. Marion Sills
approaches to patients who present with acute asthma.
is a health services researcher focusing on predictors
Important advances in the field of pediatric emergency
of emergency department utilization, health care safety
medicine, such as the use of the observation unit to pre-
net issues, asthma, health information technology,
vent hospital admissions for conditions such as dehydra-
decision support systems, and clinical care guidelines.
tion, concussions, and asthma, are also being investigated.
Dr. Eric Tham is interested in research issues in bio-
The faculty is particularly interested in emergency
medical informatics, HER safety and quality, adverse
department practice variation, resource utilization, and
drug events, and clinical decision support. Dr. Tien Vu’s
predictors of patient care outcomes in various settings.
research interests include cervical spine injury, trauma,
These interests have resulted in pediatric health services
pediatric head injury, and simulation education.
research as well as studies focusing on the usefulness
Dr. Joseph Wathen focuses on pediatric procedural
of various radiology modalities and laboratory tests in
sedation and analgesia, concussion, nerve blocks, and
the evaluation of common pediatric disease. Additional
disaster planning.
important questions that have application outside the
emergency setting include the effects of language barriers
Education
on patient care and the use of interpreters to improve care.
The Pediatric Emergency Medicine (PEM) program
Dr. Lalit Bajaj’s research interests include clinical care
works to provide the best education and hands-on
guidelines, pediatric procedural sedation and analgesia,
experience to all medical students, residents, and fellows.
bronchiolitis, and quality improvement. Dr. Joan Bothner
The program offers a core rotation in pediatric emergen-
is interested in quality improvement, physician bench-
cy medicine for third-year medical students and a senior
marking, and leadership development. Dr. Alison Brent’s
elective in pediatric emergency medicine which are open
research focuses on process/system improvement, inte-
to University of Colorado Denver medical students and
gration of emergency and urgent care medicine, imple-
external medical students. The Emergency Department
mentation of clinical care guidelines, and procedural
(ED) also trains family medicine, emergency medicine
sedation and analgesia. Injury prevention is Dr. Kathryn
and pediatric residents from UCDSOM and several pro-
Emery’s research interest. Dr. Lou Hampers focuses on
grams in the Denver Metro and Wyoming areas. The
language barriers, variation in emergency department
ED accepts electively-rotating residents in each of the
resource utilization, urgent care centers, febrile seizures,
above disciplines from around the State and around the
and acute management of malaria. Dr. Patrick Mahar is
country. The fellowship in pediatric emergency medicine
2006-2008 Departmental Report
65
sections
is a pediatric subspecialty-residency-training program
that was accredited by the ACGME in 1999 and reaccredited in 2004. The PEM fellowship is a three-year
program and accepts applications from either pediatric
emergency medicine residents or emergency medicine
residents. The overall goal of the program is to create
experts in the clinical application of pediatric emergency
medicine including the assessment of the acutely ill or
injured child. More specific clinical knowledge is gained
through eight required rotations and several elective
rotations in different subspecialty areas. The fellowship
program also includes research and teaching components.
Highlights
Joan Bothner was named Chief Medical Officer of
The Children’s Hospital.
Emergency Medicine Faculty
Faculty
Louis C. Hampers, MD, MBA, FAAP
Associate Professor of Pediatrics
Section Head, Emergency Medicine
Medical Director, The Children’s
Hospital Emergency Department
Shawna H. Abbey, MD
Senior Instructor of Pediatrics
Denise C. Abdoo, RN, MSN, CPNP
Instructor of Pediatrics
Kempe Child Protection Team
Tisha Alpers, PNP
Instructor of Pediatrics
Lalit Bajaj, MD, MPH
Associate Professor of Pediatrics
Research Director
Leigh Anne Bakel, MD
Instructor of Pediatrics
BreAnn Behlen, PA-C
Instructor of Pediatrics
Joan P. Bothner, MD
Associate Professor of Pediatrics
Chief Medical Officer,
The Children’s Hospital
Associate Dean for Clinical Affairs
at The Children’s Hospital,
University of Colorado Denver
School of Medicine
Trista Bowyer, MD
Senior Instructor of Pediatrics
Medical Director, The Children’s
Hospital at Saint Joseph Hospital
Alison Brent, MD
Associate Professor of Pediatrics
Medical Director, Network of Care
Cheryl Cavallaro, CPNP
Instructor of Pediatrics
Heather Crossen, PNP
Instructor of Pediatrics
Derrek Massanari, MD, MPH
Senior Instructor of Pediatrics
Colleen McCallum, NP-C
Senior Instructor of Pediatrics
Rupa Narra, MD
Instructor of Pediatrics
Elizabeth O’Hara, MD
Senior Instructor of Pediatrics
Catherine A. Orendac, MD
Senior Instructor of Pediatrics
Janette Prokop, MSN, APRN-C
Senior Instructor of Pediatrics
Lara D. Rappaport, MD, MPH
Assistant Professor of Pediatrics
Co-Medical Director, PALS and EMS
Jennifer Schaeffer, FNP
Instructor of Pediatrics
Carey Seatter, PA-C
Instructor of Pediatrics
Erika Sidney, MD
Instructor of Pediatrics
Assistant Medical Director,
The Children’s Hospital Emergency Department
Jennifer King, MD
Senior Instructor of Pediatrics
Medical Director, Children’s
After-Hours at Littleton
Adventist Hospital
Danute Strepman, MS, PNP
Instructor of Pediatrics
Shirley McKenzie, PNP-BC
Senior Instructor of Pediatrics
Maria Mandt, MD
Assistant Professor of Pediatrics
Co-Medical Director, PALS and EMS
66 D e p a r t m e n t o f P e d i a t r i c s
Traci Wallis, MD
Senior Instructor of Pediatrics
Angela Zang, MD
Senior Instructor of Pediatrics
Medical Director, The Children’s
Hospital North Campus
Susan Smith, MD
Senior Instructor of Pediatrics
Patrick Mahar, MD
Assistant Professor of Pediatrics
Director, Resident Education
Tien Vu, MD
Assistant Professor of Pediatrics
Director, Medical Student Education
Genie E. Roosevelt, MD, MPH
Associate Professor of Pediatrics
Fellowship Director, Section
of Emergency Medicine
Dana Jundt, ARNP
Instructor of Pediatrics
Mary Luna, MSN, CPNP
Senior Instructor of Pediatrics
Ann Van Horne, DO
Senior Instructor of Pediatrics
Medical Director, Care by
The Children’s Hospital
at Lutheran (Wheat Ridge)
Joseph E. Wathen, MD
Assistant Professor of Pediatrics
Director, Mass Casualty Incidents
Mark D. Getzoff, MD
Senior Instructor of Pediatrics
Karin Klee, MD
Senior Instructor of Pediatrics
Julieann E. Tibbetts, PNP, MSN
Senior Instructor of Pediatrics
Arleta B. Rewers, MD, PhD, MPH
Assistant Professor of Pediatrics
Marion R. Sills, MD, MPH
Assistant Professor of Pediatrics
Assistant Professor of Health
Systems, Management, and
Policy, Colorado School of
Public Health
Kathryn D. Emery, MD
Associate Professor of Pediatrics
Medical Director, “ED2”
Eric Tham, MD
Assistant Professor of Pediatrics
Medical Director, Informatics
Clinical Faculty
S. Glenn Faries, MD, MPH
Associate Clinical Professor
of Pediatrics
Sandra D. Moon, MD
Assistant Clinical Professor
of Pediatrics
Fellows
Kristen Crossmen, MD (2006-2008)
Cassie Ferguson, MD (2008-2010)
Julia Fuzak, MD (2008-2010)
Joseph Grubenhoff, MD (2007-2009)
Sarah Halstead, MD (2009-2011)
Kelley Roswell, MD (2007-2009)
Stephanie Todd, MD (2006-2008)
G. Sam Wang, MD (2009-2011)
Endocrinology
Clinical Services
The Henry Silver, MD, PhD, Pediatric Endocrine and
Growth Center at The Children’s Hospital (TCH) provides comprehensive diagnostic and treatment services
for children with disorders of growth, puberty, thyroid
function, adrenal function, calcium and phosphorus
metabolism (including rickets), osteoporosis, and many
other endocrine-related disorders. More than 4,800
sections
Dr. Philip Zeitler is Study Chair and Principal
Investigator of the Colorado Clinical Center of a national
multicenter, 7-year trial examining treatment alternatives
in adolescent type 2 diabetes (TODAY). Among other
areas of investigation, this trial examines approaches to
the promotion of life-style change, as well as the effects
of type 2 diabetes and its treatment on cardiovascular
risk and psychosocial functioning among affected teenagers. In addition, Dr. Zeitler is co-investigator with
Dr. Richard Hamman, in the Colorado School of Public
Health, on an NIH-funded study (SEARCH-CC) to
Endocrinology Front row, l - r: Bahareh Michelle Schweiger,
Margaret Moriarty, Christine Chan, Philip Zeitler;
Back row, l - r: Christina Gerhardt, Craig Taplin, Michael Kappy
examine fitness, cardiovascular, genetic, and dietary
risk factors in children with type 2 diabetes, compared
to those with type 1 and to normal age and gender-
visits to the Center are made by children from an eight-
matched controls. As an ancillary to this project,
state surrounding area each year
Dr. Zeitler, along with Dr. Nadeau and other SEARCH-
In recent years, outreach clinics have been established
CC investigators, is undertaking a project to rigorously
in eight cities, serving the needs of children in Colorado,
measure insulin resistance in type 1 and type 2 patients
Wyoming, and Montana.
in order to develop simple clinical predictors of resis-
Collaborative clinical programs with other subspe-
tance. Drs. Zeitler and Nadeau and colleagues in the
cialty departments at TCH are in place to provide endo-
Department of Medicine have developed a protocol to
crine support for children who have had bone marrow
study exercise and cardiovascular function in obese
transplantation, brain tumors, AIDS, cystic fibrosis,
insulin-resistant adolescents and adolescents with type
asthma, and a variety of metabolic and genetic disor-
2 diabetes. Drs. Zeitler and Nadeau have recently
ders, including glycogen storage disease, hypoglycemia,
published a new book entitled Insulin Resistance:
Turner syndrome, Prader-Willi syndrome, chronic renal
Childhood Precursors and Adult Disease. Dr. Zeitler
disease, and obesity-related disorders.
is collaborating with Dr. Nicole Tartaglia in the Section
of Developmental and Behavioral Pediatrics on a
Research
study of the effects of testosterone therapy on cognitive
The Section of Endocrinology is actively involved in
and behavioral development of boys with Klinefelter
research to further the understanding of endocrine
syndrome and other sex chromosome anomalies.
problems in the developing child and to improve the
Dr. Kristen Nadeau is interested in both basic science
diagnosis and care of these children. The primary areas
and clinical research, focusing on the areas of insulin
of interest of faculty in the Section include the devel-
resistance, obesity, and type 2 diabetes in children, as
opment of efficient and cost-effective approaches to
well as on the gender differences in insulin resistance
endocrine diagnosis to replace older stimulation testing
during adolescence. She has demonstrated that insulin
protocols, as well as the use of aromatase inhibitors
resistance in humans is associated with a block in insu-
to treat disorders of maturation and gynecomastia. In
lin’s PI3-kinase pathway, but not its Mitogen Activate
addition, the Section is a national leader in the study of
Protein-kinase pathway (Erk), helping to explain the
insulin resistance and associated morbidity in obese and
variable effects of insulin resistance on pathophysiol-
sedentary children.
ogy. She has also examined the regulation of SREBP-1,
2006-2008 Departmental Report
67
sections
a transcription factor important to the control of lipid
Education
synthesis by insulin as a way of understanding the ecto-
The Section of Endocrinology is actively involved in
pic lipid deposition characteristic of insulin resistance
the education and training of medical students, pediatric
in humans. Her clinical research has focused on the
residents and fellows in both pediatric and adult endo-
defects in exercise capacity that occur in patients with
crinology. Members of the Section participate in the
type 2 diabetes, and she has completed studies examin-
didactic programs of the medical school curriculum for
ing exercise capacity, ectopic hepatic and muscle lipid
first- and second-year students, as well as for third-year
deposition and their correlates in adolescents with
students rotating through the Department of Pediatrics
T2DM.
program at TCH. Section members also participate
Dr. Megan Moriarty’s research focuses on the metabolic changes that occur during puberty and how these
regularly in the didactic and bedside teaching of pediatric residents.
changes are influenced by obesity. In particular, she is
The fellowship in pediatric endocrinology is one of
currently working on a study to examine the hypothesis
the largest in the country, training fellows for academic
that obese adolescents fail to recover their prepubertal
careers in pediatric endocrinology and diabetes, and is
insulin sensitivity at the end of puberty, leading to
considered one of the strongest in the training of aca-
stress on the ability of the pancreas to make insulin and
demic pediatric diabetologists.
increasing the risk for early development of type 2 dia-
The members of the Section are also actively involved
betes. She is undertaking a longitudinal project to com-
in the education and training of practicing pediatricians
pare changes in insulin sensitivity and secretion in nor-
and family physicians throughout the Rocky Mountain
mal weight and obese adolescents from early puberty to
Region through participation in regular continuing medi-
puberty completion, as well as to examine the impact
cal education activities and regional conferences.
of pharmacologic and lifestyle interventions to prevent
these changes.
Dr. Michael Kappy is involved in a variety of
Highlights
Dr. Michael Kappy is the senior editor of the
n
research projects, primarily assessing adrenal function
in primary care settings. He is also collaborating with
textbook, Advances in Pediatrics.
Drs. Zeitler and Nadeau have recently published a
n
members of the Section of General Academic Pediatrics
new book entitled Insulin Resistance: Childhood
on vitamin D status in children with epidermolysis
Precursors and Adult Disease.
bullosa. As a member of the Lawson Wilkins Pediatric
Endocrine Society’s Drug and Therapeutics Committee,
Dr. Kappy published two position statements in
Pediatrics in 2008: the use of recombinant IGF-I in
poorly-growing children; and Vitamin D deficiency and
its prevention. The American Academy of Pediatrics
subsequently endorsed the group’s recommendation. In
addition, in collaboration with Dr. Roger Giller, Heidi
Bailey, PA-C, MS, and Jane Gralla, PhD, Dr. Kappy
has conducted a study of the development of hypothyroidism in children undergoing hematopoietic stem cell
transplantation.
68 D e p a r t m e n t o f P e d i a t r i c s
Endocrinology Faculty
Faculty
Michael S. Kappy, MD, PhD
Professor of Pediatrics
Section Head, Endocrinology
Jennifer M. Barker, MD**
Assistant Professor of Pediatrics
Rosanna V. Fiallo-Scharer, MD**
Assistant Professor of Pediatrics
Georgeanna J. Klingensmith, MD**
Professor of Pediatrics
Head, Pediatric Clinic, Barbara
Davis Center for Childhood
Diabetes
Coordinator, Diabetes Services,
The Children’s Hospital
Margaret Moriarty, MD
Instructor of Pediatrics
Kristen Nadeau, MD**
Assistant Professor of Pediatrics
Marian J. Rewers, MD, PhD, MPH**
Professor of Pediatrics
Professor of Epidemiology,
Colorado School of Public Health
Clinical Director, Barbara
Davis Center for Childhood
Diabetes
Robert H. Slover II, MD**
Associate Professor of Pediatrics
Sharon H. Travers, MD
Associate Professor of Pediatrics
sections
R. Paul Wadwa, MD**
Assistant Professor of Pediatrics
Philippe A. Walravens, MD**
Professor of Pediatrics
Philip S. Zeitler, MD, PhD**++
Professor of Pediatrics
Director, Pediatric Endocrinology
Fellowship Program
Medical Director, TCH Clinical
Translational Research Center
Medical Fellows
Christine Chan, MD (2008-2009)
Christiana Gerhardt, MD (2006-2009)
Toni Kim, MD (2005-2008)
Margaret Moriarty, MD (2005-2008)
Bahareh Michelle Schweiger,
DO (2007-2010)
Andrea Steck, MD (2006-2008)
Craig Taplin, MD (2006-2009)
Nursing Staff
Rosemary O’Dell, RN, BSN
Claudia Retamal-Munoz, RN
**Barbara Davis Center for
Childhood Diabetes Faculty
TCH Clinical Translational
Research Center Faculty
++
Epidemiology
Clinical Services
Epidemiology Front row, l - r: Roberta Smith, Marti Roe, Carl Armon;
Middle row, l - r: Carolyn Brock, Ann-Christine Nyquist, Mary GlodГ©,
Elaine Dowell, Christine Robinson; Back row, l - r: Kelly Destefano,
John James, James Todd, Susan Dolan
The Department of Epidemiology at The Children’s
tems through the development of outcomes measurement
Hospital and the Department of Pediatrics Section of
tools and analysis of large comparative datasets. Because
Epidemiology at the University of Colorado Denver School
of its geographic location, Colorado is an excellent venue
of Medicine (UCDSOM) were created in 1991 with the
for our population-based epidemiologic studies of chil-
mission to employ analytical epidemiology techniques
dren’s health care trends.
in both academic and clinical environments to improve
Dr. John James studies molecular epidemiology
health care within hospital and community populations.
and environmental epidemiology. Dr. Michael Kahn’s
Epidemiology manages infection prevention and
research focus is on clinical informatics and clinical
microbial epidemiology at The Children’s Hospital.
measure design. Dr. Ann-Christine Nyquist focuses
The Section is also responsible for outcomes measure-
on infection prevention, antibiotic use, and infectious
ment using epidemiological techniques to analyze disease
disease epidemiology. Dr. James Todd’s research inter-
trends, decrease costs, and improve clinical outcomes
ests are in diagnostic microbiology, staphylococcal and
both in hospital and community settings. Programs include
streptococcal infections, data-driven hospital and com-
Infection Prevention, Clinical Microbiology, Microbial
munity epidemiology, and outcomes.
Epidemiology, Antimicrobial Stewardship, Clinical
Informatics, Outcomes, and Community Epidemiology.
Other associated faculty research can be found in the
Section of Infectious Diseases.
Research
Research efforts include the use of molecular laboratory
Education
markers to define and control the constantly changing
The Section of Epidemiology supports the training
spectrum of microbial pathogens; the study of important
programs in general pediatrics (residents and medi-
pediatric diseases, including bacterial disease and invasive
cal students), microbiology, and infectious diseases.
staphylococcal and streptococcal infections; and the
Microbiology/ Virology/ Epidemiology daily rounds form
development of reliable and practical clinical laboratory
the basis of continuing education and exposure to infec-
methods for identification and surveillance of resistant
tion control. Infection Control is on call for questions
microorganisms.
and issues 24 hours a day, 7 days a week and is available
Outcomes research includes the application of epide-
to assist trainees with any patient questions and expo-
miologic techniques to improve health care delivery sys-
sures. During the second or third year of the pediatric
2006-2008 Departmental Report
69
sections
infectious diseases fellowship, there is a two-week rotation in the Infection Prevention Program, working on a
daily basis with the epidemiology/infection control team.
Gastroenterology, Hepatology
and Nutrition
Clinical Services
The Section of Gastroenterology, Hepatology and
Highlights
James Todd was awarded the Distinguished Physician
n
Award by the Pediatric Infectious Diseases Society
and was selected as one of Denver’s Top 150 citizens in celebration of Denver’s 150th anniversary for
“doing something extraordinary, something noteworthy, and something that is bettering the city for generations to come.”
Michael Kahn was awarded the 2007 Outstanding
n
Research Mentor Award from the UCD Clinical
Sciences Graduate Training Program.
Epidemiology Faculty
Faculty
James K. Todd, MD***++
Professor of Pediatrics and
Microbiology
Professor of Epidemiology,
Colorado School of Public Health
Section Head, Epidemiology
(Pediatrics)
Vice Chair, Advocacy (Pediatrics)
Jules Amer Chair in Community
Pediatrics
Director, Epidemiology, Clinical
Outcomes and Clinical
Microbiology, The Children’s
Hospital
Mary P. Glodé, MD*•
Professor of Pediatrics
Section Head, Infectious Diseases
Michael G. Kahn, MD, PhD+++
Associate Professor of Pediatrics
Co-Director, Colorado Clinical and
Translational Sciences Institute
Biomedical Informatics Program
Director, Colorado Clinical and
Translational Sciences Institute
Director, Clinical Informatics,
Quality and Patient Safety,
The Children’s Hospital
Ann-Christine Nyquist, MD, MSPH*
Associate Professor of Pediatrics
Associate Professor of Community
and Behavioral Health, Colorado
School of Public Health
Associate Dean of Diversity and
Inclusion, School of Medicine
Director, Pediatric Infectious
Diseases Fellowship Program
Medical Director, Infection
Prevention, The Children’s Hospital
Staff
Carl Armon, MSPH
Meghan Birkholz, MSPH
Carolyn Brock
Kelly Destefano
Susan Dolan, RN, MS, CIC
John F. James, PhD, MPH, D(ABMM),
CIC, CIE, HEM
Roberta Smith, RN, MSPH
Associated Staff
Elaine Dowell, SM (ASCP)
Christine Robinson, PhD
Nutrition is the leading center in the Rocky Mountain
Region, where board-certified pediatric gastroenterologists provide state-of-the art clinical care, consultative
services, and gastrointestinal endoscopic procedures
for children with disorders of the gastrointestinal tract,
liver, and pancreas and with complex disorders of
nutrition and liver transplantation. Outpatient consultations are available daily. Telephone consultation is
available to physicians 24 hours a day, 7 days a week.
Patient services are delivered at The Children’s Hospital
(TCH), University of Colorado Hospital, and The
Children’s Hospital Network of Care locations in Aurora,
Broomfield, Littleton, and Parker. Regional outreach is
provided in Greeley at the Northern Colorado Medical
Center; in Colorado Springs at the Memorial Hospital
Pediatric Specialty Clinic; and in Billings, Montana, at
The Eastern Region Pediatric Subspecialty Clinic.
Members of the Section also direct the Center for
Pediatric Inflammatory Bowel Diseases, the Gastrointestinal
Eosinophilic Disease Program, the Pediatric Liver Center,
the Liver Transplantation Program, the GoodLife2
Adolescent Obesity Program, and the Intestinal Failure
Program at TCH, all multidisciplinary clinics. Liver
transplant services include transplantation from split
donor livers, which allows two patients to receive livers
from a single donor, and from living-related donors.
Advanced endoscopic procedures include combined
endoscopic and laparoscopic management of biliary and
pancreatic disorders, esophageal stricture management
+
with removable stents, and single balloon endoscopy to
++
provide access to the entire small bowel. In addition,
TCH Research Institute Faculty
TCH Clinical Translational
Research Center Faculty
++
Community Pediatrics Faculty
• Medical Education Faculty
* Infectious Diseases Faculty
**Children’s Outcomes Research
Program Faculty
capsule endoscopy and esophageal impedance testing are
offered. The Intestinal Failure Program and the Nutrition
Support Service provide comprehensive care to patients
with short bowel syndrome, on home intravenous nutrition, with endoscopically placed gastrostomy tubes, and
those receiving nasogastric tube feedings at home.
70 D e p a r t m e n t o f P e d i a t r i c s
sections
Gastroenterology, Hepatology and Nutrition Faculty Front row, l - r: Brandy Lu, Shikha Sundaram, Christine Waasdorp, Joanne Masterson,
Christy Jones, Jillian Sullivan, Sophie Fillon; Middle row, l - r: Cara Mack, Rebecca Tucker, Deborah Neigut, Samantha Woodruff, Vincent Mukkada,
Jason Soden, Amethyst Kurbegov; Back row, l - r: Karim El Kasmi, David Brumbaugh, Ronald Sokol, Edward Hoffenberg, Michael Narkewicz,
Robert Kramer, Steven Colson, Glenn Furuta
Research
static liver diseases; studies of bone mineral metabolism
The Section includes many of the leading researchers in
in chronic liver disease; investigation of the etiology,
pediatric gastroenterology, hepatology and nutrition in
pathogenesis, and outcomes of biliary atresia; a clini-
the country. Research in the Section bridges across basic
cal trial of corticosteroids in biliary atresia; a study of the
sciences, translational medicine, and clinical research
cause and a clinical trial in acute liver failure in children;
related to pediatric gastrointestinal and liver diseases.
diagnosis and treatment of liver disease associated with
Ongoing laboratory research includes investigations of
cystic fibrosis; new treatments for inflammatory bowel
the roles of cell signaling, mitochondrial dysfunction,
disease; evaluation of outcomes of pediatric liver trans-
and oxidative stress in hepatocyte injury in the chole-
plant recipients; and a longitudinal study of genetic causes
static and fatty liver; the role of innate immunity in par-
of intrahepatic cholestatic liver diseases in childhood.
enteral-nutrition associated liver injury; characterization
Dr. Glenn Furuta’s research seeks to understand the
of the pathogenesis of biliary atresia in a mouse model;
role of eosinophils in the gastrointestinal tract. Clinical
the role of eosinophils in cellular injury and remodeling
research investigations focus on new diagnostics and
of the esophagous and intestines; vaccine development
treatments in eosinophilic esophagitis. Basic and transla-
for diabetes prevention; and mechanisms of immuno-
tional studies seek to determine the relationship between
logic injury in a mouse model of celiac disease.
the eosinophils and resident cells of the intestinal muco-
Clinical research includes clinical trials of new thera-
sa, including the epithelium. Dr. Edward Hoffenberg
pies for hepatitis B and C; evaluation of the genetics,
studies the epidemiology and clinical features of celiac
epidemiology and outcomes of celiac disease; investiga-
autoimmunity in early childhood and conducts clinical
tions of the etiology and development of new diagnos-
trials in inflammatory bowel disease and inherited poly-
tics and optimal therapies of eosinophilic esophagitis;
posis syndromes. Dr. Robert Kramer’s research interests
development of new therapies for fibrotic and chole-
include clinical trials in eosinophilic esophagitis,
2006-2008 Departmental Report
71
sections
Gastroenterology, Hepatology and Nutrition Staff Front row, l - r: LoAnn Tran, Sara Fidanza, Annette McCoy, Missy Olson, Joanna Grenawalt,
Michelle Henry, Hallie Johannisson; Middle row, l - r: Alice Garrett, Cynthia Wyman, Dian Downen, Jaina Olesen, Nicole Valentine, Wendy Moore,
Adrianne Burgess, Joanne Newton; Back row, l - r: Tuesda’ Charles, Christina Canale, Cristy Good, Felicia Timoteo, Judy Scheibeler,
Zachary Robinson, Pamela Short
the roles of therapeutic and biliary endoscopy in children,
delivery. Dr. Jason Soden’s major scientific interest is
clinical research in pediatric obesity, and outcomes of
the management and outcomes of children with intes-
bariatric surgery in children. Dr. Edwin Liu’s work
tinal failure. He is involved in a new national effort to
focuses on the study of autoimmunity in type 1 dia-
better understand the cause and improve therapies in
betes and celiac disease, analysis of current diagnostic
parenteral nutrition-associated liver disease and other
testing for celiac disease, and the genetics of celiac dis-
complications of short bowel syndrome. Dr. Ronald
ease. Dr. Amethyst Kurbegov evaluates outcomes of
Sokol’s major scientific interests include treatment and
gastrointestinal disorders. Dr. Cara Mack investigates
prevention of complications of cholestatic liver diseases;
the cause of biliary atresia in both humans and in a
human vitamin E deficiency states; oxidative mecha-
mouse model. Her research is defining the immuno-
nisms of liver injury in cholestasis, copper toxicity, and
logic pathways involved in the bile duct and liver injury
hepatic steatosis; regulation of mitochondrial dysfunc-
of this disease and searching for targets of this aber-
tion in hepatocellular necrosis and apoptosis; the use of
rant immune response. In addition, she is investigating
antioxidants in human health and disease; and develop-
genetic influences on the susceptibility to biliary atresia.
ing a severity of illness scoring system for acute liver
Dr. Michael Narkewicz’s research interests include
failure. Dr. Sokol is the Chair of the Biliary Atresia
clinical studies in children with biliary atresia, clini-
Research Consortium and the Cholestatic Liver Disease
cal trials and transmission in chronic viral hepatitis,
Consortium. Dr. Shikha Sundaram is investigating the
hematologic and immunologic complications following
role of factors that trigger non-alcoholic fatty liver dis-
pediatric liver transplantation, improved diagnosis and
ease in children who are overweight. She is a member
treatment of cystic fibrosis-associated liver disease, and
of a national group studying the cause and treatment
clinical trials in acute liver failure. Dr. Narkewicz is
of primary sclerosing cholangitis in children. She also
Chair of the Cystic Fibrosis Liver Disease Study Group.
studies the long-term outcomes of pediatric liver trans-
Dr. Deborah Neigut’s primary interest is in education
plant patients.
72 D e p a r t m e n t o f P e d i a t r i c s
sections
Education
Our Section has a strong commitment to educating and
training the next generation of pediatricians. Our faculty teach and mentor fellows, residents, and medical
students. Our three-year, ACGME-accredited fellowship
training program in pediatric gastroenterology (funded
by the NIH) provides a unique academic, clinical, and
research experience for two fellows per year. We provide
a myriad of continuing education for local and regional
pediatricians. We also provide training for pediatric and
other residents in inpatient, outpatient, and procedural
aspects of pediatric gastroenterology, hepatology and
nutrition. Additional development of clinical and/or basic
research skills is available. Pediatric gastroenterology,
hepatology and nutrition is an important part of the
pediatric clerkship curriculum for third-year medical
students at the University of Colorado Denver School
of Medicine. Our faculty provide a lecture in gastroenterology as part of the clerkship’s core lecture series and
supervise medical students on the inpatient pediatric services. A fourth-year medical student elective in pediatric
gastroenterology, hepatology and nutrition emphasizes
the outpatient evaluation and management of common
and uncommon clinical problems, as well as time on the
inpatient and consultation service and GI Procedure Unit.
Highlights
Ronald Sokol is Principal Investigator and Director
n
of the new Colorado Clinical and Translational
Sciences Institute at UCD, funded by the NIH.
Glenn Furuta is Executive Board Chairman of The
n
International Gastrointestinal Eosinophil Researchers.
Michael Narkewicz was President of the Medical
n
Staff at TCH.
Ronald Sokol is Chair of the Steering Committees
n
of the Biliary Atresia Research Consortium and the
Cholestatic Liver Disease Consortium, both funded
by the NIH.
Michael Narkewicz is Chair of the Cystic Fibrosis
n
Liver Disease Study Group, funded by the Cystic
Gastroenterology, Hepatology and Nutrition Faculty
Faculty
Ronald J. Sokol, MD++
Professor of Pediatrics
Section Head, Gastroenterology,
Hepatology and Nutrition
Vice Chair, Clinical and
Translational Research
Director, Colorado Clinical and
Translational Sciences Institute
Program Director, TCH Clinical
Translational Research Center
Associate Medical Director, Pediatric
Liver Center/Liver Transplantation
Program
Karim El Kasmi, MD, PhD
Assistant Professor of Pediatrics
Sophie Fillon, PhD++
Instructor of Pediatrics
Glenn T. Furuta, MD++
Associate Professor of Pediatrics
Director, Gastrointestinal Eosinophil
Disease Program
Edward J. Hoffenberg, MD
Associate Professor of Pediatrics
Director, Program for Pediatric
Inflammatory Bowel Diseases
Christy Jones, PA-C
Senior Instructor of Pediatrics
Robert E. Kramer, MD
Assistant Professor of Pediatrics
Director of Endoscopy
Medical Director, GoodLife2
Adolescent Obesity Clinic
Amethyst Kurbegov, MD
Assistant Professor of Pediatrics
Edwin Liu, MD**
Assistant Professor of Pediatrics
Cara L. Mack, MD
Associate Professor of Pediatrics
Michael R. Narkewicz, MD
Professor of Pediatrics
Hewit-Andrews Chair in Pediatric
Liver Disease
Director, Clinical Services,
Pediatric Gastroenterology
Medical Director, Pediatric Liver
Center/Liver Transplantation
Program
Director, Fellowship Training
Program
Arnold Silverman, MD
Professor Emeritus of Pediatrics
Jason Soden, MD
Assistant Professor of Pediatrics
Darcy Solanyk, MS, PA-C
Senior Instructor of Pediatrics
Judith Sondheimer, MD
Professor Emerita of Pediatrics
Shikha S. Sundaram, MD, MSCI
Assistant Professor of Pediatrics
Medical and Postdoctoral Fellows
Barrett Barnes, MD (2004-2007)
David Brumbaugh, MD (2007-2010)
Steven Colson, MD (2008-2011)
Eric Gumpricht, PhD (2003-2008)
Karina Irizarry, MD (2005-2008)
Jane Keng, MD (2004-2007)
Brandy Lu, MD (2006-2009)
Vincent Mukkada, MD++ (2005-2008), Research Scholar (2008-2009)
Jillian Sullivan, MD (2008-2011)
Christine Waasdorp, MD (2007-2010)
Samantha Woodruff, MD++
(2006-2009)
Research Associate
Michael Devereaux, BS
Professional Research Assistant
Clinical Staff
Kristin Brown, MS, RD
Christina Canale, RN
Dian Downen, RN BSN
Sara Fidanza, MS, RN, CPNP
Alice Garrett, RN, BSN
Michelle Henry, RD
Annette McCoy, RN, BSN
Joanne Newton, RN, BSN
Jaina Olesen, RN, BSN
Missy Olson, BSN, RN
Alicia Smith, MS, BSN, RN
LoAnn Tran, BSN, RN
Liver Transplant Coordinator
Diane Dovel, BS, RN
**Barbara Davis Center for
Childhood Diabetes Faculty
TCH Clinical Translational
Research Center Faculty
++
Gastrointestinal Eosinophil
Center Faculty
++
Deborah Neigut, MD
Associate Professor of Pediatrics
Stephanie Petersburg, PA-C++
Senior Instructor of Pediatrics
Fibrosis Foundation and the NIH.
2006-2008 Departmental Report
73
sections
General Academic Pediatrics
Clinical Services
The Children’s Hospital (TCH) and UCDSOM
Department of Pediatrics have had a long-term commitment to integrating primary care for low-income children with the academic missions of training and clinical
research. Currently there are two primary care clinics
at TCH: the Child Health Clinic (CHC) and the Special
Special CHC Programs
The Reach Out and Read program allows clinicians the
opportunity to supply books to parents of children aged
six months to five years in order to encourage the development of reading. Volunteers read to children in busy
afternoon waiting rooms in order to model the enjoyment and importance of early reading.
The Bright Beginnings program makes available early
Care Clinic.
childhood educational and family support materials
Clinical Services and Programs
Book,” which are given to parents of clinic patients.
The CHC delivers longitudinal, comprehensive primary
care for underserved children. Currently, we are seeing
19,000 visits per year; however, due to space and staff
limitations, we have implemented restrictions on accepting new children into the practice. Many of our patients
have chronic illness such as asthma, seizures, behavioral
problems (ADHD, depression, learning difficulties, language delay), so that they have a high level of medical
need. We are now only accepting newborns who were
delivered at University Hospital as well as siblings of
existing patients, or patients of TCH subspecialists who
request that we provide primary care in order to better coordinate care. The overwhelming majority of the
children have public insurance: 68% have Medicaid,
9% SCHIP (Child Health Plan), 14% commercial insurance, and 6% are uninsured. The CHC has an integrated
mental and behavioral health program that provides
on-site evaluation and therapy, screening for postpartum
depression, and “Ages and Stages” formalized developmental screening and referrals, as well as an asthma
quality care initiative, all of which also instruct our
trainees in better health care practices. The CHC is the
major primary care training site for the Department. The
faculty trains 42 residents during their weekly continuity
clinic site for group practice; and 36 pediatric residents,
24 family medicine residents, and 24 physician assistant
students in monthly general ambulatory care rotations
per year. In the mornings, the clinic is staffed with three
faculty, while the afternoons require five faculty to cover
the additional patients seen in group practice.
74 D e p a r t m e n t o f P e d i a t r i c s
such as the “Learningames” book and “My First Picture
These materials encourage parents to take an active and
positive approach to teaching their children.
The Special Care Clinic offers comprehensive primary
and consultative care to children with special health care
needs, including children with developmental disabilities, genetic disorders, chronic medical problems, and
prematurity. The clinic is staffed by six physicians who
are specialists in pediatrics (with subspecialty training
in a variety of fields, including genetics, neurodevelopmental disabilities, developmental-behavioral pediatrics,
and neonatology), as well as three experienced pediatric
nurse practitioners. It has a child psychiatrist experienced in caring for children with dual diagnoses (cognitive disabilities plus psychiatric issues). Three pediatric
residents have their continuity clinic experience in
Special Care Clinic. The clinic has the support of nutrition and respiratory therapy at all clinic sessions and has
therapists available to assess children during some clinic
sessions. It is supported by four nurses, a social worker,
an administrative assistant, and a full-time scheduler. As
well as providing primary care to children with special
needs who live in the Denver and Aurora metropolitan
areas, the clinic also provides consultative care and
schedules complex coordinated appointments to multiple other specialists within TCH for patients who travel
from many of the surrounding states and rural areas of
Colorado.
Additional consultative services, teaching programs
and multidisciplinary clinics:
sections
living in Warren Village, with the help of the Section’s
administrative and volunteer support. Warren Village
supports women by providing temporary housing, parenting classes, child care, and work preparation programs.
The Cleft Lip/Cleft Palate Clinic offers comprehensive
services to children with this common birth anomaly
and is served by the Section’s faculty who are part of a
multidisciplinary professional team.
The University of Colorado President’s Leadership
Class Mentorship Program mentors undergraduate college students interested in medicine as a career. Students
General Academic Pediatrics Front row, l - r: Christina Kim, Shale Wong,
Amy Shriver, Maya Bunik, Karen Dodd, Maureen Lenssen; Back row, l - r:
Matthew Daley, Brian Stafford, David Fox
The Epidermolysis Bullosa Clinic, a multidisciplinary
receive a diverse exposure to the medical field, including
clinical, research, administrative, and advocacy experiences.
Research
clinic held monthly, provides for evaluation and care
The General Academic Pediatrics Section continues
coordination by General Pediatrics, Hand Surgery,
to expand its research enterprise, with the addition of
Gastroenterology, Anesthesiology, Physical Therapy,
new research faculty and an increase in federal funding.
Occupational Therapy, Pain Management Specialists
Immunization delivery research has been a major focus
and Psychology, Nutrition, and Social Work Services.
for the last ten years, involving Drs. Stephen Berman,
The General Pediatric Consultation Service provides
Robert Brayden, Matthew Daley, Simon Hambidge, and
consultation to Colorado and Wyoming pediatricians
Allison Kempe; and our Section is a recognized leader in
and family physicians for pediatric diagnostic dilemmas,
this area nationally. Over the past three years we have
failure-to-thrive, recurrent otitis media, and difficult
received five federal grants in the area of immunization
behavioral problems.
delivery, examining attitudes of physicians nationally
The International Adoption Clinic is a consultation
regarding vaccine policy issues, adolescent vaccine deliv-
service for children in the Rocky Mountain Region
ery, and school-based delivery of both influenza and
adopted from abroad. The clinic offers comprehensive
adolescent vaccines.
medical evaluations of children, with a focus on infec-
Preventive dental care for children has been a grow-
tious diseases, growth and development, and psychologi-
ing area of focus, involving Drs. Matthew Daley, Patricia
cal issues particular to international adoptees. The clinic
Braun, and Allison Kempe, and there have been three
also provides pre-adoption consultations.
grants funded in this area. Drs. Steven Poole, Elaine
The Foster Care Clinic delivers primary care, acute
Morrato, and Allison Kempe are evaluating the Colorado
care, and consultations for children who live in foster or
Children’s Healthcare Access Practice (CCHAP) program,
kinship care. Outpatient visits are provided for children
aimed at increasing private pediatricians’ involvement in
aged birth through 18 years, with a focus on identifying
providing care to low-income children.
all of the child’s physical, behavioral and developmen-
Several projects assessing quality improvement – in
tal needs. Additionally, a central site is created for the
the areas of asthma management (Drs. Maya Bunik and
child’s immunizations and available medical records.
Allison Kempe) in collaboration with the Pulmonology
The Warren Village Medical Student Clinic gives wellchild and minor illness care to children of single mothers
Section, and in mental health care within the pediatric
setting (Drs. Maya Bunik and Allison Kempe) in
2006-2008 Departmental Report
75
sections
collaboration with the Department of Psychiatry – have
interest is pediatric telephone triage and advice. Dr. Brian
received grant funding support. Telephone care and self-
Stafford’s research interests include perinatal and infant
triage over the internet continue to be a focus for several
mental health.
faculty (Drs. Barton Schmitt, Maya Bunik, and Allison
Kempe); and our faculty are currently involved in a col-
Education
laborative project with Kaiser Permanente to evaluate
General Academic Pediatrics is committed to teaching
the acceptability and effectiveness of self-triage over
a variety of trainees, including medical students, physi-
the internet. Our new focus in obesity prevention (Drs.
cian assistant students, family medicine and pediatric
Maya Bunik, Christina Kim, and Allison Kempe) has
residents, and fellows. We provide education on primary
resulted in the completion of several projects and the
care and general acute care illness topics through a vari-
submission of two new grants.
ety of approaches, such as direct precepting by attending
faculty, hour-long morning conferences, and 10-minute
Additional projects for many of this Section’s faculty are
brief talks in the continuity clinics. We also expose our
listed in the Children’s Outcomes Research Program.
trainees to developmental and mental health screening
and counseling through our integrated mental health
General Academic Pediatrics faculty are active in a
program, CLIMB. They learn our systematic approach
variety of research areas. Dr. Stephen Berman is involved
to Asthma QI for the outpatient asthma visit as well as
in access to health care and immunization services deliv-
the ONE STEP Second Hand Smoke initiative.
ery research. Dr. Robert Brayden participates in immunization services delivery research. Dr. Maya Bunik’s
Highlights
interests include breastfeeding support for low-income
n
Stephen Berman was named The Children’s Hospital
Chair in General Pediatrics.
women, quality improvement in asthma management,
and primary care mental health services and after-hours
care/telephone triage. Dr. Sara Carpenter’s interests
Stephen Berman received the Department of
n
Pediatrics’ Career Teaching Scholar Award.
involve health care services for children in foster care.
Dr. Matthew Daley is involved in research regarding
immunization delivery and preventive dental services for
children. Dr. Ellen Elias studies the physiological effects
of the cholesterol deficiency seen in Smith-Lemli-Opitz
syndrome and is also interested in caring for children
with osteogenesis imperfecta. Dr. David Fox is interested in quality of care and medical decision-making
regarding special needs children. Dr. Allison Kempe
directs the Children’s Outcomes Research Program, and
her research interests include immunization delivery,
telephone care, and health care access in low-income
children. Dr. Christina Kim’s research interests are the
development and evaluation of interventions to decrease
childhood obesity. Dr. Steven Poole’s research is focused
on issues of access to care for children with Medicaid
insurance. Dr. Barton Schmitt’s current primary research
76 D e p a r t m e n t o f P e d i a t r i c s
General Academic Pediatrics Faculty
Faculty
Stephen Berman, MD**
Professor of Pediatrics
Section Head, General Academic
Pediatrics
The Children’s Hospital Chair
in General Pediatrics
Mark E. Anderson, MD**
Associate Professor of Pediatrics
Deirdre Arnholz, MD
Senior Instructor of Pediatrics
Patricia A. Braun, MD**
Associate Professor of Pediatrics
Robert M. Brayden, MD++
Associate Professor of Pediatrics
Director, Child Health Clinic
Jeffrey M. Brown, MD, MPH***
Professor of Pediatrics
Maya Bunik, MD**
Associate Professor of Pediatrics
Sara C. Carpenter, MD
Assistant Clinical Professor
of Pediatrics
Director, Foster Care Clinic
Betsey M. Chambers, MD**
Instructor of Pediatrics
Matthew F. Daley, MD**
Associate Professor of Pediatrics
Director, International Adoption
Clinic
Karen Z. Dodd, MS, PNP
Senior Instructor of Pediatrics
William H. Edwards, MD**
Instructor of Pediatrics
sections
Ellen R. Elias, MD++
Associate Professor of Pediatrics
Director, Special Care Clinic
Rachel A. Estorge, MD**
Instructor of Pediatrics
Steven G. Federico, MD**
Assistant Professor of Pediatrics
David Fox, MD
Senior Instructor of Pediatrics
Simon J. Hambidge, MD, PhD****++
Associate Professor of Pediatrics
Director, Community Health
Pediatrics, Denver Health
Megan G. Henderson, MD**
Instructor of Pediatrics
Luz M. Jimenez, MD**
Instructor of Pediatrics
Paritosh Kaul, MD**++
Associate Professor of Pediatrics
Allison Kempe, MD, MPH**
Professor of Pediatrics
Director, Primary Care Research
Fellowship
Director, Children’s Outcomes
Research Program
Christina A. Kim, MD**
Instructor of Pediatrics
Kristine A. Knuti, MD**
Instructor of Pediatrics
Mary C. Kohn, MD
Assistant Professor of Pediatrics
Kari L. Lillehammer, PA-C
Instructor of Pediatrics
Glenda Louch, CPNP, MS
Senior Instructor of Pediatrics
Kathryn A. Love-Osborne, MD**++
Associate Professor of Pediatrics
N. Elaine Lowery, JD, MSPH**
Clinical Instructor of Pediatrics
Program Manager, Colorado
Immunization Information System
Chanda C. McDaniel, MD**
Instructor of Pediatrics and
Internal Medicine
Catherine L. McIlhany, MD**
Instructor of Pediatrics
Paul Melinkovich, MD**
Professor of Pediatrics
Professor of Community and
Behavioral Health, Colorado
School of Public Health
Lora H. Melnicoe, MD, MPH**
Senior Instructor of Pediatrics
Gregory Q. Miranda, MD**
Instructor of Pediatrics
Elaine H. Morrato, DrPH**
Assistant Professor of Pediatrics
Assistant Professor of Clinical
Pharmacy, School of Pharmacy
Assistant Professor of Health
Systems, Management and Policy,
Colorado School of Public Health
Mary E. O’Connor, MD, MPH**
Associate Professor of Pediatrics
Carol R. Okada, MD**•
Instructor of Pediatrics
Associate Program Director,
Pediatric Residency Program
Stacey Pfannenstiel, PA
Instructor of Pediatrics
Laura L. Pickler, MD
Assistant Professor of Pediatrics
Steven R. Poole, MD++
Professor of Pediatrics
Section Head, Community Pediatrics
Vice Chair, Ambulatory and
Community Affairs
Donald W. Schiff, MD
Clinical Professor Emeritus
of Pediatrics
Barton D. Schmitt, MD++
Professor of Pediatrics
Medical Director, After-Hours
Telephone Care Program
Elaine N. Scholes, MD**
Professor of Pediatrics
James E. Shira, MD
Professor Emeritus of Pediatrics
Janine Young, MD**
Assistant Professor of Pediatrics
Primary Care Fellows
Karen L. Kelminson, MD (2008-2010)
Instructor of Pediatrics
Clinical Faculty
Jerry J. Baros, MD**
Associate Clinical Professor
of Pediatrics
Edward Berman, MD
Clinical Instructor of Pediatrics
Carol Deborah Siegel Friefeld, MD,
MSPH**
Assistant Clinical Professor
of Pediatrics
Jody A. Maes, MD**
Clinical Professor of Pediatrics
Carolyn Munro, MD
Clinical Instructor of Pediatrics
Sonja B. O’Leary, MD**
Clinical Instructor of Pediatrics
Norman Scott, MD
Associate Clinical Professor
of Pediatrics
Clinical Staff
Claudia Mustafa, LCSW
* Pediatric Hospital Medicine
Faculty
**Denver Health Faculty
** Children’s Outcomes Research
Program Faculty
+
Intellectual and Developmental
Disabilities Research Center
Faculty
+
Clinical Genetics and Metabolism
Faculty
+
Kempe Children’s Center Faculty
++
Community Pediatrics Faculty
++
Adolescent Medicine Faculty
• Medical Education Faculty
Hematology, Oncology and
Bone Marrow Transplantation
Clinical Services
The Children’s Hospital Center for Cancer and Blood
Disorders (CCBD) is one of the premier pediatric hematology/oncology/bone marrow transplant (BMT) programs in the country. The CCBD provides state-of-the-art
clinical care, has strong academic programs, and has a
Amy E. Shriver, MD
Instructor of Pediatrics
nationally recognized fellowship training program. Our
Brian Stafford, MD, MPH
Assistant Professor of Psychiatry
and Pediatrics
nurse practitioners and physician assistants, 10 medical
Catherine C. Tilt, CPNP
Instructor of Pediatrics
Heather G. Varnell, MD**
Instructor of Pediatrics
program includes 23 MD faculty members, 12 pediatric
fellows pursuing advanced training in the discipline, a
dedicated and highly skilled nursing team, along with
social workers and child life specialists. The CCBD
clinical program occupies the entire 7th floor of the
Stephen D. Vogler, MD**
Instructor of Pediatrics
294-bed Children’s Hospital. Facilities include a dedi-
Kimberly Washington, CPNP, MS
Senior Instructor of Pediatrics
clinic and infusion center. There are approximately
Kathryn M. Wells, MD, FAAP**+
Assistant Professor of Pediatrics
Shale L. Wong, MD, MSPH•
Associate Professor of Pediatrics
Director, Medical Student Education
in Pediatrics
Director, Mentored Scholarship
Co-Director, LEADS
cated 24-bed inpatient unit with adjacent outpatient
1,063 CCBD inpatient hospital admissions per year
and 13,500 outpatient visits.
The CCBD Hematology Program provides care to
children and adolescents with a variety of blood disorders. Our hemophilia and thrombosis program is one of
2006-2008 Departmental Report
77
sections
stem cell rescues, in addition to conventional matched
sibling allogeneic BMT.
The CCBD has a very active research program that
includes clinical, translational (“bench to bedside”), and
basic laboratory research programs in all areas of the
subspecialty. Many of our faculty members are internationally recognized for their expertise in specific areas.
Research
The Children’s Hospital Center for Cancer and Blood
Disorders (CCBD) includes 23 MD or MD/PhD and one
PhD faculty members with a variety of interests in cliniHematology, Oncology and Bone Marrow Transplantation
Front row, l - r: Janie Kappius, Kelly Maloney, Lia Gore, Roger Giller,
Douglas Graham; Middle row, l - r: Molly Hemenway, Jennifer Madden,
Kathleen Pool, Sarah Birch, Michael Wang Robinson; Back row, l - r:
Amy Keating, Ralph Quinones, Nicholas Foreman, Stephen Hunger,
Margaret Macy, Edythe Albano
cal, translational (“bench to bedside”), and laboratory
the best in the world. Other CCBD hematology subspe-
Leukemia and Lymphoma Society, the CDC, and the
cialty programs focus on sickle cell anemia, disorders of
Maternal and Child Health Bureau. Major areas of
white blood cell function, and how the immune system
clinical research focus include trials for children with all
influences blood cell number and function.
types of cancer, development of new cancer therapies
The CCBD Oncology Program is a principal par-
research. Faculty members published over 157 scientific articles between 2006-2008 and have grant funding from major national agencies including the NIH,
National Cancer Institute, American Cancer Society,
(Experimental Therapeutics Program), sickle cell ane-
ticipating member of the Children’s Oncology Group
mia, hemophilia and clotting disorders, and studies
(COG), a national consortium of pediatric cancer inves-
of different modes of bone marrow transplantation.
tigators. Approximately 200 newly diagnosed cancer
Translational and basic laboratory research programs
patients are treated each year. Specialized oncology
include studies of leukemia and brain tumor biology
programs include the Neuro-Oncology Program, which
and genetics, development of new molecularly targeted
provides care to patients with brain tumors, and the
therapies for various types of cancer, genetic studies
Experimental Therapeutics Program, which focuses on
of von Willebrand disease and other bleeding disorders,
development and testing of new therapies for patients
white blood cell function, and studies that seek to
that have failed standard treatments. Our comprehen-
understand why reactions occur to blood transfusions.
sive program also includes a focus on treatment of ado-
Faculty members of the CCBD include internationally
lescents and young adults with cancer and a dedicated
recognized leaders in research in Hemophilia (Dr. Marilyn
survivorship program, Helping Oncology Patients Excel
Manco-Johnson), white blood cell function (Dr. Daniel
(HOPE Clinic).
Ambruso), transfusion reactions (Dr. Christopher Silliman),
The CCBD BMT Program was established in 1993
and leukemia biology and treatment (Dr. Stephen Hunger).
and has performed about 500 hematopoietic stem cell
Dr. Edythe Albano studies supportive care and man-
transplants. Each year, we perform about 45 BMT
agement of infections in children and adolescents with
procedures of all types, including unrelated donor cord
cancer. Dr. Daniel Ambruso investigates mechanisms
blood transplants, T cell depleted matched unrelated
regulating bactericidal activity of human neutrophils
donor transplants, autologous and allogeneic peripheral
and monocytes. He also studies neutrophil function in
78 D e p a r t m e n t o f P e d i a t r i c s
sections
thermal injury/trauma, chronic granulomatous disease,
new treatments for children and adolescents with cancer
platelet activating factor generation in stored blood
that failed current therapies. Dr. Gore was co-founder
components, and immune-related blood disorders.
of the Pediatric Experimental Therapeutics Investigator
Dr. Deborah DeRyckere directs the laboratory com-
Consortium (POETIC) that includes nine major pediatric
ponent of the Pediatric Experimental Therapeutics
oncology programs from the U.S. and Canada. She also
Program that is focused on development of new treat-
is a member of the adult ETP at University of Colorado
ments for children and adolescents with cancer that
Hospital and participates in clinical research in Acute
failed current therapies. Major research efforts are
Lymphoblastic Leukemia (ALL) through the Children’s
directed at developing preclinical models for leukemia
Oncology Group (COG). Dr. Douglas Graham directs
and using novel imaging techniques to image cancers
a research lab that studies the MER family of recep-
and assess treatment response. Dr. Jorge DiPaola is
tor tyrosine kinases and how members of this family
engaged in research related to von Willebrand disease,
are involved in development of cancer and clotting
hemophilia, and other bleeding disorders. His lab uses
disorders. His lab has shown that interfering with the
large scale genetic studies to identify genes that influ-
function of MER proteins can potentiate chemotherapy
ence blood cell numbers and those that are mutated in
in leukemia and brain tumors and is developing new
bleeding disorders. Dr. Nicholas Foreman directs an
therapies directed at MER. Dr. Graham is also the co-
active clinical and laboratory research program focused
principal investigator of our NIH-funded T32 grant to
on pediatric brain tumors. Major components of his
train pediatric cancer researchers. Dr. Brian Greffe has
research program include clinical trials for children with
a research focus on survivorship and the late effects of
relapsed and refractory brain tumors and lab studies of
cancer treatment. He is also board certified in pallia-
the genetics of pediatric glial tumors that are designed
tive care and engages in research related to pediatric
to help develop new therapies. Dr. Timothy Garrington
palliative and hospice care. Dr. Taru Hays is engaged
is interested in clinical research of bone tumors. He has
in research studies in pediatric blood disorders. She is
a major interest in medical education and research on
the co-author of a new textbook on pediatric blood cell
methods to improve teaching of medical students and
morphology. Dr. Stephen Hunger is an internationally
physicians. Dr. Garrington is a Course Director in the
recognized expert in leukemia genetics and the treat-
Medical School and also directs the CCBD Pediatric
ment of childhood ALL. Dr. Hunger serves as Chair of
Hematology/Oncology Fellowship Training Program.
the COG ALL Disease Committee, which is responsible
Dr. Roger Giller is engaged in clinical research in germ
for the design and conduct of clinical trials and linked
cell tumors and in allogeneic hematopoietic stem cell
laboratory research studies that include over 70% of
transplantation (HSCT). He directs clinical trials that
U.S. and Canadian children with ALL. He is also the
seek to define the role of HSCT for treatment of chil-
principal investigator of our NIH-funded T32 grant
dren and adolescents with cancer and nonmalignant dis-
to train pediatric cancer researchers. Dr. Amy Keating
orders. Dr. Neil Goldenberg studies blood clotting and
studies the role of the MER family of receptor tyrosine
thrombotic disorders. He developed and is Co-Director
kinases in brain tumors and leukemia. She is develop-
of the Colorado Pediatric Stroke Program at The
ing new brain tumor therapies that are directed at MER
Children’s Hospital, a unique multidisciplinary pro-
proteins. Dr. Margaret Macy is engaged in clinical and
gram based both in the CCBD and the Child Neurology
laboratory research that link the CCBD ETP and neuro-
Section. Dr. Lia Gore founded and directs the CCBD
oncology programs. Her laboratory research is focused
Pediatric Experimental Therapeutics Program (ETP)
on developing therapies that target epigenetic modifica-
that is dedicated to development and clinical testing of
tions in tumors, while her clinical research is designed
2006-2008 Departmental Report
79
sections
to test new therapies for children and adolescents with
viruses in human cancer. He is now developing a
brain tumors that have failed conventional treatments.
research program on the immunological aspects of
Dr. Kelly Maloney is a leader in clinical trials for child-
coagulation disorders, including inhibitor development
hood ALL. She is Co-Chair of the COG clinical trial for
in hemophilia and the biology of catastrophic antiphos-
children with standard risk ALL that will enroll about
pholipid antibody syndrome.
4,000 U.S. and Canadian children with this disease.
She also directs the CCBD Clinical Trials Support Unit.
Education
Dr. Marilyn Manco-Johnson is an international leader
The goal of our ACGME-accredited, three-year fellow-
in research on pediatric hemostasis and thrombosis. She
ship program is to train fellows in the scientific and clini-
is Director of the UCD Hemophilia and Thrombosis
cal aspects of pediatric hematology, oncology, and bone
Center and directs a wide variety of research studies
marrow transplantation as preparation for a career in
designed to define optimal treatments for children with
academic medicine. Excellence of clinical care is empha-
hemophilia and other bleeding disorders. Her work on
sized throughout. Of equal importance is the training of
prophylactic use of clotting factor concentrates has rev-
fellows who will become future clinical and basic science
olutionized the treatment of children with severe hemo-
researchers and leaders in the field. Our highly competitive
philia. Dr. Rachelle Nuss directs the Pediatric Sickle
program typically trains three new fellows yearly. There is
Cell Program through the UCD Sickle Cell Treatment
also a one-month, inpatient/outpatient rotation for pedi-
and Research Center. Her research is focused on opti-
atric residents at any level. Residents gain experience with
mizing treatment for children with sickle cell anemia
children with a variety of oncologic and hematologic dis-
and includes collaborative studies with Dr. Silliman
eases. Experiences include a combined outpatient/inpatient
on the role of neutrophils in acute chest syndrome of
consultative rotation and a rotation with a focus on BMT.
sickle cell disease. Dr. Christopher Porter has a research
program focused on identifying new drugs to overcome
Highlights
treatment resistance in acute myeloid leukemia and
n
Three members of the Section were named UCD
developing new techniques for use in gene therapy.
New Inventor of the Year: Drs. Douglas Graham,
Dr. Ralph Quinones directs the Stem Cell Processing
Lia Gore, and Deborah DeRyckere.
Lab at TCH and also serves as the Medical Director
Dr. Marilyn Manco-Johnson is recognized as one of
n
of the University of Colorado Umbilical Cord Blood
the world’s leading pediatric hemophilia researchers.
Bank. He is engaged in clinical trials of HSCT in
She published a study in the New England Journal
children and in research concerning novel methods of
of Medicine that established preventative use of
graft engineering. Dr. Christopher Silliman directs a
hemophilia factor concentrates is more effective
research laboratory with the primary interest being the
than episodic treatment of bleeding disorders.
pro-inflammatory effects of transfusion on the innate
Dr. Jorge DiPaola joined the program in 2008 as the
n
immune system, especially the interactions between
Postle Family Chair in Pediatric Cancer and Blood
neutrophils and vascular endothelium in the context of
Disorders and Director of Basic and Translational
acute lung injury and post-injury multiple organ failure.
Research in Pediatric Hemostasis and Thrombosis.
Dr. Rajeev Vibhakar directs a research laboratory that
Dr. Christopher Silliman was named to the National
n
studies micro RNA function in pediatric brain tumors
Blood Foundation Hall of Fame for his work on
and the genetics of medulloblastoma. Dr. Michael Wang
Transfusion-Associated Acute Lung Injury.
has a research interest in lymphomas and the role of
80 D e p a r t m e n t o f P e d i a t r i c s
sections
Hematology, Oncology and Bone Marrow Transplantation Faculty
Faculty
Stephen P. Hunger, MD
Professor of Pediatrics
Section Head, Hematology,
Oncology and Bone Marrow
Transplantation
The Ergen Family Chair in Pediatric
Cancer
Edythe A. Albano, MD
Associate Professor of Pediatrics
Clinical Director, Oncology
Daniel R. Ambruso, MD
Professor of Pediatrics, Cell and
Developmental Biology, and
Microbiology
Sarah Birch, PNP
Senior Instructor of Pediatrics
Melissa Christensen RN, MSN, PNP
Senior Instructor of Pediatrics
Deborah A. DeRyckere, PhD
Instructor of Pediatrics
Jorge DiPaola, MD
Associate Professor ofPediatrics
and Genetics
The Postle Family Chair in Pediatric
Cancer and Blood Disorders
Andrew Donson, BS
Research Associate of Pediatrics
Tracey Flanagan, PA-C
Senior Instructor of Pediatrics
Nicholas K. Foreman, MB ChB
Professor of Pediatrics
Tanner Seebaum and Zachary
Tschetter Chair in Neuro-Oncology
Director, Pediatric Neuro-Oncology
Program
Robert L. Garcea, MD
Professor of Pediatrics, Cell and
Developmental Biology
Timothy P. Garrington, MD
Assistant Professor of Pediatrics
Director, Pediatric Hematology/
Oncology/BMT Fellowship Program
Roger H. Giller, MD
Professor of Pediatrics
Clinical Director, Bone Marrow
Transplantation
Neil A. Goldenberg, MD, PhD+
Assistant Professor of Pediatrics
and Medicine
Co-Director, Colorado Pediatric
Stroke Program
Lia Gore, MD
Associate Professor of Pediatrics
and Medicine
Douglas K. Graham, MD, PhD
Assistant Professor of Pediatrics
and Immunology
Brian S. Greffe, MD
Associate Professor of Pediatrics
Taru Hays, MD
Professor of Pediatrics
Clinical Director, Hematology
Molly Hemenway, ND, RN, AC/CPNP
Senior Instructor of Pediatrics
Janie Kappius, RN, MSN, CPNP
Senior Instructor of Pediatrics
Amy K. Keating, MD
Assistant Professor of Pediatrics
Margaret E. Macy, MD
Instructor of Pediatrics
Nancy King, RN, MSN, CPNP
Senior Instructor of Pediatrics
Jennifer R. Madden, RN, MSN, CPNP
Assistant Professor of Pediatrics
Kelly W. Maloney, MD
Associate Professor of Pediatrics
Marilyn J. Manco-Johnson, MD+
Professor of Pediatrics and Associate
Professor of Pathology
Director, UCD Hemophilia and
Thrombosis Center
Rachelle Nuss, MD
Professor of Pediatrics
Bernice Pasut, RN, MSN, CPNP
Senior Instructor of Pediatrics
Angela C. Peltz, PA-C, MPAS
Senior Instructor of Pediatrics
Kathleen Pool, RN, CPNP
Senior Instructor of Pediatrics
Christopher Porter, MD
Instructor of Pediatrics
Elizabeth Pounder, PA-C
Senior Instructor of Pediatrics
Ralph R. Quinones, MD
Associate Professor of Pediatrics
Co-Director, Pediatric Hematology/
Oncology/BMT Fellowship Program
Christopher C. Silliman, MD, PhD
Professor of Pediatrics and Surgery
Associate Medical Director, Bonfils
Blood Center
Rajeev Vibhakar, MD
Assistant Professor of Pediatrics
Michael Wang, MD
Assistant Professor of Pediatrics
Fellows
Abdulrahman Alsultan, MD
(2005-2008)
James Bradley Ball, MD (2006-2009)
Rachel Bercovitz, MD (2008-2009)
Kristen Eisenman, MD (2007-2009)
Jessica Goodman, MD (2005-2006)
Mindy Grunzke, MD (2007-2009)
Amy K. Keating, MD (2005-2007)
Jeffrey Knipstein, MD (2007-2009)
Ashley Jones, MD (2008-2009)
Susan Lindemulder, MD (2005-2008)
Margaret E. Macy, MD (2005-2008)
Kerry Moss, MD (2006-2009)
Jean Mulcahy-Levy, MD (2008-2009)
Christopher Porter, MD (2005-2007)
Lisa Reaves, MD (2006-2009)
Dana Salzberg, MD (2005-2006)
Kelly Sawczyn, MD (2005-2006)
Karen Walton
Clinical Nurse Manager,
Outpatient Services
Social Work Staff
Jane Ambro, LCSW
Rebecca Cort, LCSW
Amity Good, LCSW
Hadassah Wasserman, MSW
Nadia Benkhalil, CRA
Therapeutic Recreation/Child
Life Specialists
Allison Donohue, MS, CTRS/CCLS
Cody Hudson, MS, CCLS
Tommi McHugh, MA, CCLS
Ponzio Creative Arts Therapy
Program
Tisha Adams, MA, ATR-BC, LPC
Art Therapist
Administrative Staff
John Schliep
Administrative Director
Pam Bowry
ETP Program Coordinator
Shari Hansen
BMT Program Coordinator
Katie Patterson
Neuro-Oncology Program Coordinator
Diane Frelund
Fellowship Program Coordinator/
Hematology Staff Assistant III
Tina Green, BS
Oncology Staff Assistant III
Colette Hook
BMT Staff Assistant III
Clinical Staff
Ellen Servetar, MS, RN, CPON
Clinical Director
Donna Border, MS, RN, CPON
Clinical Nurse Manager,
Inpatient Services
Lucy Compoz
Business Operations Coordinator
Jammie Reichel, BSN
Clinical Coordinator, Educator
Kelly West, MS, RN, CPON
Clinical Nurse Educator
Lacey L. Felmlee
Staff Assistant III
Clinical Research Staff
Barb Shepperd, RN, CCRP
Clinical Research Manager
Janet Bathurst, MS, MBA
BMT Analyst
Elaine Hild, RN, BSN
Research Nurse
Kimberlee Horst, CTR
Cancer Registrar
Nancy Kipke, CRA
Kate Marquart, CRA
BMT and Neuro-Oncology
Lynette Magree, CRA, CCRP
Kristien Mann, RN, BSN, CRA
Research Nurse
Ann Ribe, CRA, BA
University of Colorado Denver
Hemophilia and Thrombosis
Center
Brenda Riske, MS, MBA, MPA
Director, Clinical and Research
Services
Judy Primeaux, RPh, MA
Director, Pharmacy and Financial
Operations
Amy Eiss, RN, CPNP
Amy Zagrocki, RN, CPNP
Christine Hodges
Administrative Assistant
Colorado Sickle Cell Treatment
and Research Center
Kathryn Hassell, MD
Director, Professor of Medicine
Cheri Burge
Administrator
+
Colorado Pediatric Stroke
Program Faculty
2006-2008 Departmental Report
81
sections
Infectious Deseases
Clinical Services
The Section of Infectious Diseases (ID) provides excellent inpatient and outpatient clinical services by nationally recognized physicians and performs cutting-edge
research in the fields of infectious diseases and HIV.
The Infectious Diseases consultation team is on call 24
hours a day, 7 days a week. In 2008, the team consulted
on and followed approximately 400 inpatients at The
Children’s Hospital. The ID service provides telephone
consultations to physicians in the Rocky Mountain
Region and receives more than 100 phone consultations a week. The Infectious Diseases consultation team
meets daily with the microbiology and virology laboratories and hosts a weekly case management conference.
Outpatients are seen weekly in Infectious Diseases and
HIV Clinics and monthly in the Sinus Clinic. The HIV
clinic is the site for the Denver Pediatric AIDS Clinical
Trials Unit, funded by the NIH. The Children’s Hospital
Immunodeficiency Program (CHIP) provides unique
family-centered care for children and adolescents with
HIV. CHIP’s multidisciplinary team offers comprehensive medical care coupled with counseling and social
support to families in the Rocky Mountain Region.
ID faculty conduct a wide variety of basic science and
clinical research focusing on vaccine-preventable diseases, international health, TB, pediatric viral infections,
emerging viral respiratory diseases, Kawasaki disease,
Staph toxin diseases, and HIV infection.
Research
The Section of Infectious Diseases has an active basic
and translational research program with more than five
million dollars of federal funding yearly. The Section
has 22 full-time faculty engaged in a broad range of
research, including respiratory viral pathogens, enteric
viral diseases, international health, HIV, TB, Kawasaki
disease, Staph toxin disease, and vaccine-preventable
diseases. We participate in multiple national clinical
trials of antiviral agents, antiretroviral medications,
and vaccines.
82 D e p a r t m e n t o f P e d i a t r i c s
Dr. Mark Abzug directs clinical research on patients
with viral infections, infections in immune-compromised
patients, and chronic sinusitis. He is involved in several
national collaborative clinical trials of antiviral therapies. Dr. Marsha Anderson performs clinical research
on vaccines, vaccine-preventable disease, and Kawasaki
disease. Emily Barr, PNP, CNM, has a research focus on
adherence to HIV medications, long-term effects of antiretroviral exposure, prevention of perinatal transmission
of HIV, HIV in pregnancy, and international HIV treatment trials. Dr. Sam Dominguez’s research focuses on
the epidemiology, disease associations, and pathophysiology of newly discovered human and bat coronaviruses,
and he is interested in emerging pathogens. He also
pursues laboratory and clinical studies on the etiology
and epidemiology of Kawasaki disease. Jennifer Dunn,
MS, RN, FNP-BC, has a research focus on pediatric HIV
disease and treatments as well as adolescent HIV and
maternal-to-child transmission of HIV. Dr. Mary GlodГ©
is involved in clinical vaccine trials and pursues clinical studies of the etiology, epidemiology, and therapy
of Kawasaki disease. Heather Heizer, MPAS, PA-C,
manages the outpatient Infectious Diseases Clinic at
The Children’s Hospital. She is interested in numerous
aspects of infectious diseases and currently has clinics
that include PICC line/bone and joint infections as
well as a clinic dedicated to MRSA and to Kawasaki
disease. She currently is also involved in developing
studies with other faculty members in the department
to examine the natural history and therapy of MRSA.
Dr. Myron Levin is studying the immune response to
herpes virus infections and methods of treating and
preventing such infections, including antiviral therapy
and active immunization. He does basic research on the
nature of latency of herpes viruses in human neurons.
A vaccine to prevent shingles in elderly individuals
has been developed and licensed through his clinical
research, and further investigations of this vaccine are in
progress. Dr. Shaobing Li’s research focuses on molecular diagnosis for viral infections. Dr. Robin McEvoy
participates in research evaluating the effects of HIV
sections
Infectious Diseases Front row, l - r: Carol Salbenblatt, Samuel Dominguez, Daniel Reirden, Sean O’Leary, Heather Heizer; Middle row, l - r:
Adriana Weinberg, John Ogle, Ann-Christine Nyquist, Elizabeth McFarland, Donna Curtis, Jennifer Sabell, Kristin Beam; Back row, l - r:
Jennifer Dunn, Myron Levin, Eric SimГµes, Mark Abzug, Marsha Anderson, Mary GlodГ©, Sarah Parker, James Todd
infection and antiretroviral treatment on the cognitive,
the contributions of thioesterases to cell wall biosynthe-
language, neurological, psychological development
sis in Mycobacterium tuberculosis and their potential
of infants, children, and teens infected or exposed to
for drug target development. Suzanne Paul, MSN, RN,
HIV. Dr. Elizabeth McFarland is studying the matura-
FNP-C, has a research focus on pediatric HIV disease
tion of cell-mediated immune responses in both normal
and treatments as well as adolescent HIV and maternal-
and HIV-infected infants, immune responses to HIV
to-child transmission of HIV. Dr. Suchitra Rao is study-
vaccines in exposed newborns, the role of cytotoxic
ing the epidemiology of the newly discovered respiratory
T-lymphocytes in the pathogenesis of congenitally
viruses, WU and KI, and their role in respiratory tract
acquired HIV infection, pediatric HIV clinical trials of
infections in children. She is also working on a study
antiretroviral therapy and vaccines, and complications of
exploring the neurological outcomes and predictors of
HIV and treatment. Dr. Ann-Christine Nyquist serves as
encephalitis in children, as well as a study of renal toxicity
Medical Director for Infection Control at The Children’s
associated with the use of acyclovir. Dr. Harley Rotbart’s
Hospital. Her research focus includes antimicrobial utili-
research interests are in the molecular and cellular
zation and resistance, immunization and hospital epide-
mechanisms by which enteroviruses and rhinoviruses
miology/infection control. Dr. Sean O’Leary is working
cause disease, as well as methods for rapid molecular
on the epidemiology and natural history of MRSA infec-
diagnosis and treatment of these infections. Dr. Eric SimГµes
tions in healthy children. He is also investigating adverse
is working with the World Health Organization for the
events associated with immunizations as part of a multi-
management of common pediatric conditions in devel-
center, FDA-funded study. Dr. Sarah Parker is studying
oping countries (Integrated Management of Childhood
2006-2008 Departmental Report
83
sections
Illness) and studies the epidemiology, pathogenesis, and
by our faculty – Drs. Carlos Perez, Marsha Anderson,
prevention of the short- and long-term effects of respi-
Chris Robinson, Betsy McFarland, and Mary GlodГ©.
ratory syncytial virus infection in children. Dr. Adriana
Since 1993, the Section has received continuous
n
Weinberg is studying cellular and humoral immune
funding of our comprehensive HIV program for
responses to microbial organisms and regulation of
children and adolescents with HIV infection, includ-
immune responses with emphasis on HIV and opportu-
ing clinical trials.
nistic infections. She is also studying the effect of hormonal contraceptives on immune responses. Amy Witte,
RN, MSN, FNP-C, has a research focus on HIV transmission, pathophysiology, and treatment in youth.
Education
The Section of Infectious Diseases is committed to educating and training medical students, physician assistants, residents, and fellows. Our faculty and fellows
have won numerous teaching awards for their outstanding educational contributions. Our Section has maintained an active and highly respected fellowship training
program for the past 30 years. Our three-year ACGME
fellowship training program provides comprehensive ID
clinical experience in addition to broad research opportunities. Training for residents in pediatric infectious
diseases is provided through clinical consultations to the
ward team and outpatient clinics. A month-long elective
provides a more intensive experience as an infectious
diseases consultant and a brief period in the clinical
microbiology laboratory. Training for students begins
with core lectures for third-years taking the pediatric
clerkship. An elective in pediatric infectious diseases is
available for fourth-year medical students who have
completed a pediatric clerkship.
Highlights
Eric SimГµes developed and implemented the
n
Integrated Management of Childhood Illness (IMCI)
program for the WHO, now implemented in more
than 86 countries worldwide.
Myron Levin developed and licensed a new
n
shingles vaccine.
The first report of Enterovirus 71 as a cause of
n
paralytic disease in children in Colorado was made
84 D e p a r t m e n t o f P e d i a t r i c s
Infectious Diseases Faculty
Faculty
Mary P. Glodé, MD*•
Professor of Pediatrics
Section Head, Infectious Diseases
Vice Chair, Education
Mark J. Abzug, MD++
Professor of Pediatrics
Medical Director, Clinical Trials
Organization
Marsha S. Anderson, MD•
Associate Professor of Pediatrics
Associate Program Director,
Pediatric Residency Program
Emily A. Barr, CPNP, CNM
Senior Instructor of Pediatrics
Guang-Yun Cai, PhD
Research Associate of Pediatrics
Samuel R. Dominguez, MD, PhD
Assistant Professor of Pediatrics
Jennifer Dunn, MS, RN, FNP-BC
Instructor of Pediatrics
Heather Heizer, MPAS, PA-C
Instructor of Pediatrics
Myron J. Levin, MD
Professor of Pediatrics and Medicine
Shaobing Li, MD
Research Associate of Pediatrics
Robin E. McEvoy, PhD
Clinical Instructor of Pediatrics
Elizabeth J. McFarland, MD
Professor of Pediatrics
Director, The Children’s Hospital
HIV Program
Ann-Christine Nyquist, MD, MSPH*
Associate Professor of Pediatrics
Associate Professor of Community
and Behavioral Health, Colorado
School of Public Health
Associate Dean of Diversity and
Inclusion, School of Medicine
Director, Pediatric Infectious
Diseases Fellowship Program
Medical Director, Infection
Prevention, The Children’s Hospital
John W. Ogle, MD**
Professor of Pediatrics
Director of Pediatrics, Denver Health
Vice Chair, Affiliate Denver Health
Sarah K. Parker, MD
Assistant Professor of Pediatrics
Suzanne M. Paul, MSN, RN, FNP-C
Senior Instructor of Pediatrics
Daniel H. Reirden, MD++
Assistant Professor of Pediatrics
Harley A. Rotbart, MD
Professor of Pediatrics and
Microbiology
Vice Chair, Academic Affairs
Eric A. SimГµes, MB, BS, DCH, MD
Professor of Pediatrics
James K. Todd, MD***++
Professor of Pediatrics and
Microbiology
Professor of Epidemiology,
Colorado School of Public Health
Section Head, Epidemiology
(Pediatrics)
Vice Chair, Advocacy (Pediatrics)
Jules Amer Chair in Community
Pediatrics
Director, Epidemiology, Clinical
Outcomes and Clinical
Microbiology, The Children’s
Hospital
Adriana Weinberg, MD
Professor of Pediatrics, Medicine,
and Pathology
Medical Director, Clinical Virology
Laboratory, University of Colorado
Hospital
Amy Witte, RN, MSN, FNP-C
Senior Instructor of Pediatrics
Fellows
Donna Curtis, MD, MPH (2008-2011)
Sean O’Leary, MD (2007-2010)
Suchitra Rao, MD (2006-2009)
Staff
Jan Hughes-Austin, MS
Darcy Bawiec, MS
Professional Research Assistant
sections
treatment, and referral services for children and adoles-
Kris Beam
Business Administrative Coordinator
Tina (Yee) Powell, MS
Professional Research Assistant
Megan Canon
Research Assistant
Kelly Richardson, MS
Professional Research Assistant
Jennifer Canniff, BA
Professional Research Assistant
John Rino
Professional Research Assistant
Jason Child, Pharm-D
Jennifer Sabell
Program Assistant, Fellowship
Coordinator
Infants in Foster and Kinship Care
Carol R. Salbenblatt, RN, MSN, CNS
The Kempe Infants in Foster and Kinship Care program
Scott Simpson
Professional Research Assistant
provides innovative and urgently needed long-term
Elizabeth Cothren
Shannon Dunlap, MSW
Jessica Forsyth, MSW
Glenda Fortenberry
Staff Assistant
Josephine Greenquist
Research Assistant
Paul Harding, MS
Professional Research Assistant
Maurice Jermaine Ka-Mashiriuche
Kay Kinzie, MSN, FNP-BC
Nancy Lang, RN
Professional Research Assistant
Chrystal Lopenz
Professional Research Assistant
Roland Marcus, BS
Professional Research Assistant
Patricia Michalek, RN
Priti Narasimhan, MBA
Christine Osborne
Professional Research Assistant
Malinda Paddock, LCSW
Jennifer Pappas, LCSW, MPH
Julie Patterson
Research Associate
Kathleen Peng
Professional Research Assistant
Jessica Peterson
Staff Assistant
Jamie Sims, MSW
Deidre (Slape) Ferrall, BS
Jennifer Springer
Professional Research Assistant
Adriana Tovar Salazar, MS
Professional Research Assistant
Lora Trevis, MSW, LCSW
Annie Vazquez, BS
Professional Research Assistant
cents who may have been physically or sexually abused
or neglected. Sensitive care is provided by dedicated
clinicians to help the hospital and community identify,
treat, and console child abuse victims and their families.
services to extremely vulnerable abused and neglected
babies who enter foster and kinship (relative) care within the city and county of Denver. Additionally, the clinical program is part of a larger clinical trial that will test
the effectiveness of the intervention.
Fostering Healthy Futures
The Kempe Fostering Healthy Futures (FHF) program
Karen Vockrodt
fosters resilience and promotes success for children who
Blessing Wazara, BS
have been placed in foster care following child abuse
Michele White-Samuels, BS
Program Assistant
and neglect. Through a multifaceted program, FHF
Carol Workman, RN, BSN
Philip Zachariah, MB, BS
Professional Research Assistant
Virginia Zimmerman, BA
* Epidemiology Faculty
**Denver Health Faculty
**Children’s Outcomes Research
Program Faculty
Community Pediatrics Faculty
++
Clinical Trials Organization
Faculty
++
Adolescent Medicine Faculty
• Medical Education Faculty
++
Kempe Center for the
Prevention and Treatment
of Child Abuse and Neglect
seeks to reduce risk behaviors (delinquency, substance
abuse, sexual and self-destructive behaviors) and foster
competence (academic achievement, adaptive mental
health functioning, healthy relationships and quality of
life) for youth in foster care. Fostering Healthy Futures
is the only known randomized, controlled clinical trial
of an intervention designed specifically for preadolescent
youth in out-of-home care.
Kempe Under Sixes Program
The Kempe Under Sixes Program (KUSP) reduces mental
health problems for abused and neglected children under
six years of age who are involved with the Denver Child
Welfare System and have developed, or are at high risk
for, social/emotional problems. The KUSP program
Clinical Services
is currently supported by a contract with the Denver
Kempe Child Protection Team
Department of Human Services (DDHS), which desig-
The Children’s Hospital offers the only hospital-based
nates KUSP as a preferred provider of mental health ser-
multidisciplinary child abuse program in Colorado. The
vices for its very young children. This is a highly unusu-
Kempe Child Protection Team’s mission is to offer com-
al and innovative collaboration between mental health
prehensive, multidisciplinary consultation, assessment,
and child welfare. KUSP is a unique program designed
2006-2008 Departmental Report
85
sections
Kempe Center for the Prevention and Treatment of Child Abuse and Neglect Front row, l - r: Jen Hughes, Felicia Pezold, Kim Pierpoint,
Meghan Dahlin, Martha Huckaby, Rose Rahman, Heather Taussig; Middle row, l - r: Kim Upchurch, Christina Little, Linda Jensen,
Jenny Koch-Zapfel, Edward Garrido, William Betts, Amelie Bracher; Back row, l - r: Terri James-Banks, Rob Murchison, Tabitha Webster,
Brian Stafford, Laura Mann, Robert Clyman, Vong Luangphaxay, Donald Bross
to create a system of mental health services for abused
tal health services for maltreated children. KTP helps
and neglected infants, toddlers, and preschoolers who
severely emotionally disturbed three- to six-year-old
are involved with the Denver Child Welfare System.
children who have been abused and neglected move on
to regular preschools, Head Start Programs, or elemen-
Kempe Perpetration Prevention Program
tary schools. This highly specialized, year-long treatment
The Kempe Perpetration Prevention Program (KPPP)
program provides a full range of mental health and milieu
decreases the risk of children being abusive, as children,
services to decrease problem behavior, increase social
as adolescents, and ultimately as the next generation of
skills, and improve academic performance of the children.
adults, by promoting primary, secondary, and tertiary
perpetration prevention strategies. We also work to
Training, Education, and Consultation
reduce the risk that any child will begin abusing (“pri-
The Kempe Training, Education, and Consultation
mary prevention”), and to identify and intervene with
Program provides highly acclaimed training, education,
“at risk” groups before they abuse (“secondary preven-
and consultation services to help audiences within
tion”). By studying research to understand what factors
Colorado and across the country prevent and treat
contribute to the initiation of abusive behaviors, KPPP
child abuse and neglect. We annually conduct 6 courses
develops strategies to prevent or disrupt those factors.
involving 18 sessions on various aspects of child maltreatment. Our training programs consistently receive
Kempe Therapeutic Preschool
“exceptional” marks in independent evaluations con-
The Kempe Therapeutic Preschool (KTP) is recognized
ducted by Colorado Department of Human Services
nationally for specializing in early childhood men-
(CDHS). Our continuing education programs have
86 D e p a r t m e n t o f P e d i a t r i c s
sections
consults, and collaborates with professionals from hospitals, primary care clinics, and public health and mental
health agencies in the Denver metropolitan area. The
program also provides early intervention and treatment
services to new mothers, fathers, infants, and families
affected by postpartum depression.
Kempe Trauma Collaborative
The focus of Kempe’s Trauma Collaborative is on
young abused and neglected children because they are at
extraordinary risk for emotional and behavioral problems. In addition to clinical service, the focus will be on:
(a) coordinating systems of care for young children and
families (e.g., child welfare, mental health, developmental
Child Protection Team Front row, l - r: Michele Kelly, Lucinda Tanner,
Denise Abdoo; Back row, l - r: Antonia Chiesa, Linda Jensen, Lisa Justis,
Andrew Sirotnak
services); (b) conducting interdisciplinary staff trainings
on topics that address the needs of young abused and
neglected children; and (c) collaborating with Trauma
served over 730 professionals including more than 500
Centers from all over the country to develop, evaluate,
case workers and foster parents.
and implement effective interventions for child trauma.
Kempe Policy Program
Research
The major focus of the Kempe Policy Program is to
The Kempe Center for the Prevention and Treatment of
conduct empirical research on and to advocate for
Child Abuse and Neglect’s research programs examine a
changes in federal and state policies to improve child
range of issues that affect abused and neglected children.
abuse prevention and treatment. This is often done in
One major focus is on the development of clinical trials
collaboration with the Kempe Foundation’s Advocacy
for youth in foster care. The Center has implemented a
Committee, which serves the principal role of advocat-
study of infants who enter foster care to examine factors
ing on child abuse and neglect issues. The committee
that affect developmental and mental health outcomes
identifies issues that are relevant to child abuse and
as well as access to health and developmental services.
neglect. The Center’s Policy Program serves as a partner
The Center has also implemented an intensive home-
on the Advocacy Committee, and Center faculty serve
based intervention for the infants and their families to
as co-developers of policy positions, as clinical and
test if it can improve their developmental and mental
research experts, and as educators.
health outcomes. Another project is conducting secondary data analyses to support the development of an
Postpartum Depression Intervention Program
intervention trial to improve mental health outcomes for
Kempe’s Postpartum Depression Intervention Program
preteens who enter foster care.
(PPDIP) promotes public awareness, provides evidence-
Another area of research examines a number of pol-
based treatment, educates primary care and mental
icy-relevant factors that influence access to services and
health professionals, and advocates for perinatal mental
behavioral health and child welfare outcomes for chil-
health on behalf of the women and their babies who are
dren in the child welfare system. One study is examining
affected by postpartum depression. The PPDIP educates,
the influence of Medicaid mental health capitation on
2006-2008 Departmental Report
87
sections
access to and the costs of services for children receiving
research interests include perinatal and infant mental
publicly funded mental health and child welfare services.
health. Dr. Heather Taussig’s research interests are in the
Other studies examine the influence of kinship
field of child abuse and neglect and foster care, with an
(relative) care versus foster care on access to services;
emphasis on randomized controlled trials of interventions.
outcomes of youth who enter out-of-home placement;
long-term outcomes for adults who were previously
Education
in out-of-home placement; outcomes for children who
Our section has a strong commitment to the education of
return home or remain in out-of-home placement; physi-
pediatricians and other primary care providers, postdoc-
cal abuse injuries; and infant emotional development.
toral and medical fellows, child psychiatry and pediatric
Dr. Donald Bross conducts research on how programs
residents, and medical, nursing, social work, and CHA/
that benefit children can be effectively promoted; the
PA students. As faculty in the ACGME-accredited pedi-
effectiveness of services supporting child protection pro-
atric residency program, we are involved daily in clinical
fessionals; and on the law and ethics of pediatric advo-
teaching. Our faculty is also involved in the pediatric
cacy. Dr. Antonia Chiesa’s research interest is in cervical
clerkship curriculum for third-year medical students at
spine injury in Shaken Baby Syndrome (SBS) and SBS
the University of Colorado Denver School of Medicine,
prevention. Dr. Robert Clyman’s research interests focus
providing a lecture on basic child abuse principles and
on developmental risk, clinical interventions and early
participating in a simulated child abuse patient evalua-
intervention, and empirical policy research with infants,
tion. An elective in child abuse and neglect is available
youth, and adolescents in abused and neglected children
for fourth-year medical students who have completed
and their families. He is currently directing a longitudinal
a pediatric clerkship. The course is designed to educate
study of 275 young infants who have entered foster or
students who are pursuing primary care or psychiatry
kinship care and their families, examining the impact of
residency in both the basic and more advanced principles
child welfare policy, neighborhood, family and child fac-
of child abuse and neglect. Our two- to three-year child
tors on the development of the children’s functioning,
abuse fellowship program trains the next generation of
and the early onset of psychopathology. His policy
clinician leaders in the field of Child Abuse Pediatrics, a
research focuses on the impact of major U.S. and state
newly recognized ABP board-eligible subspecialty.
child welfare policies, such as reunification and kinship
care, on the well-being of youth. Dr. Karen Frankel’s
Highlights
research interests are in infant mental health and child
n
In 2008, the Kempe Child Protection Team celebrated
maltreatment. Dr. Christina Little’s research interests are
50 years of treatment and prevention of child abuse
in child abuse and neglect, high-risk families involved
and neglect. As one of the country’s first child protec-
with the child welfare and criminal justice systems, and
tion teams established in 1958 at University Hospital,
interventions to ameliorate adverse child experiences.
this program and the State of Colorado, played a piv-
She has a particular focus on children aged birth to
otal role in bringing national attention to the problem
preschool. Gail Ryan, MA, has focused her research on
of child abuse.
primary, secondary, and tertiary prevention of abusive
The Children’s Hospital Board of Directors issued
n
behaviors in childhood and adolescence. Dr. Andrew
a Resolution on November 13, 2008, Honoring the
Sirotnak’s research interests focus on the etiology and
50th Year Anniversary of the Child Protection Team.
identification of child physical abuse injuries, child
Richard D. Krugman was selected as the Kempe
n
abuse educational interventions for professionals, and
Lecturer by the International Society for Prevention
peer support for residents in training. Dr. Brian Stafford’s
of Child Abuse and Neglect, Hong Kong.
88 D e p a r t m e n t o f P e d i a t r i c s
sections
Kempe Center Faculty
Faculty
Robert B. Clyman, MD**
Associate Professor of Pediatrics
and Psychiatry
Jack and Viki Thompson Chair
in Child Maltreatment and
Family Health
Executive Director, Kempe Center
for the Prevention and Treatment
of Child Abuse and Neglect
(until July 2009)
Denise Abdoo, RN, MSN, CPNP
Senior Instructor of Pediatrics
Donald C. Bross, JD, PhD
Professor of Pediatrics and
Family Law
Director of Education and
Legal Counsel
Director, START
Debbie Carter, MD
Assistant Professor of Psychiatry
Associate Psychiatric Director,
Kempe Therapeutic Preschool
Sara Culhane, JD, PhD
Senior Instructor of Pediatrics
Research Director, Kempe
Fostering Healthy Futures
Orah Fireman, LCSW
Instructor of Pediatrics
Leslie Fitzpatrick, LCSW
Instructor of Pediatrics
Karen A. Frankel, PhD
Assistant Professor of Psychiatry
Director, Kempe Therapeutic
Preschool
Edward Garrido, PhD
Senior Instructor of Pediatrics
Edward J. Goldson, MD•
Professor of Pediatrics
Evelin Gomez, PhD
Instructor of Pediatrics
Gail Ryan, MA
Assistant Clinical Professor
of Pediatrics
Director, Kempe Perpetration
Prevention Program
Terri James-Banks, MSW, LCSW
Senior Instructor of Pediatrics
Clinical Director, Kempe
Under Sixes Program
Consultant, START
Lisa Justis, LCSW, CTS
Child Protection Team
Michele Kelly, PsyD
Assistant Clinical Professor
of Pediatrics
Neonatology
Clinical Services
The Section of Neonatology provides full clinical sup-
Ruth S. Kempe, MD
Associate Professor Emerita
of Pediatrics and Psychiatry
(deceased)
port for infants and their families at multiple hospitals
Richard D. Krugman, MD
Professor of Pediatrics
Vice Chancellor for Health Affairs
and Dean, School of Medicine
services to physicians and their patients throughout
Christina Little, PhD
Senior Instructor of Pediatrics
and Psychiatry
Research Director, Kempe Infants
in Foster and Kinship Care
in the Denver metropolitan area, as well as 24 hours a
day, 7 days a week consultative, referral, and transport
the Rocky Mountain Region. Tertiary care services are
coordinated between The Children’s Hospital and the
perinatal services at University of Colorado Hospital
and Denver Health Medical Center. Consultative and
administrative services are provided daily to Level I
Jeffrey L. Metzner, MD
Clinical Professor of Psychiatry
Clinical Director, Perpetration
Prevention Treatment Program
and II nurseries at Lutheran Medical Center, Centura
Andrew P. Sirotnak, MD
Associate Professor of Pediatrics
Interim Section Head
(beginning October 2009)
Director, Kempe Child Protection
Team
Department Head, Child Abuse and
Neglect, The Children’s Hospital
Director, Child Abuse and Neglect
Fellowship Program
County, Centura Health Porter Hospital, Centura Parker
Lucinda T. Tanner, CHA/PA
Senior Instructor of Pediatrics
Research
Heather N. Taussig, PhD
Associate Professor of Pediatrics
and Psychiatry
Director, Kempe Fostering
Healthy Futures
Health St. Anthony Central Hospital, Centura Health
St. Anthony North Hospital, Centura Health Summit
Hospital, Northern Colorado Medical Center, Boulder
Community Hospital, Platte Valley Medical Center,
Longmont United Hospital, and Poudre Valley Hospital.
Consultative and patient care are also provided on a
referral basis at other metropolitan area nurseries.
The research interests and expertise of various faculty
have fostered programmatic areas of excellence in pulmonary hypertension of the newborn at The Children’s
Hospital and in the study of metabolism of the very
Kathryn M. Wells, MD, FAAP***
Assistant Professor of Pediatrics
premature infant at University of Colorado Hospital.
Robyn Wertheimer-Hodas, MSW
Instructor of Pediatrics
isotopes and indirect calorimetry to study glucose and
Fellows
Antonia Chiesa, MD (2005-2008)
Sandeep Narang, MD (2008)
Administrative Staff
Kim Pierpoint, MSHA
Administrator, Kempe Center
* General Academic Pediatrics
Faculty
**Denver Health Faculty
**Children’s Outcomes Research
Program Faculty
• Developmental and Behavioral
Pediatrics Faculty
New areas of research interest include the use of stable
amino acid utilization in the premature infant, use of
nitric oxide in the term and preterm infant, and cardiopulmonary adaptation to altitude.
Faculty are also involved in basic research at the
molecular, cellular, organ, and whole animal levels.
Areas of excellence include research on carbohydrate
and amino acid metabolism and on organ blood-flow
regulation. In vivo studies emphasizing chronically catheterized animals take place at the University of Colorado
Denver School of Medicine Perinatal Research Center.
Areas of research interest include placental, cerebral,
2006-2008 Departmental Report
89
sections
Neonatology Front row, l - r: James Barry, Erica Wymore, Jinny Lavezzi, Rachel Wright, Elizabeth Thilo, Jason Gien; Middle row, l - r: Amy Wood,
Georgina Garza, Cassidy Delaney, M. Douglas Jones, Jr., Laura Brown, Patti Thureen, Jan Paisley; Back row, l - r: Paul Rozance, Robert Rock,
Peter Hulac, Regina Reynolds, Thomas Parker, John Kinsella, Randall Wilkening
hepatic, and muscle metabolism in normal, growth-
Dr. Mackenzie Frost’s current research interests are
retarded, and hypoxic fetal lambs. Studies requiring sta-
glucose effect on pancreatic function, insulin regulatory
ble isotopic analysis are completed in collaboration with
pathway, beta cell mass and apoptosis, and amino acid
a number of investigators on the UCD and Colorado
regulation. She is also interested in surgical placement of
State University campuses. In vitro studies currently
indwelling catheters, chronic and acute infusions, blood
focus on growth-factor regulation and placental devel-
sampling, necropsy, islet isolation, static cellular incuba-
opment under conditions of placental insufficiency.
tions, immunohistochemical staining, and photomicros-
Dr. Russell Anthony’s research focus is early placental
copy. Dr. Jed Friedman’s research specialization is tran-
development in growth-restricted pregnancies. Dr. James
scription factors involved in energy balance and obesity,
Barry’s research seeks to understand how the fetal myo-
mechanisms for fatty liver development, fetal program-
cardium adapts to intrauterine growth restriction and
ming and molecular pathways to insulin resistance in
how these adaptations may contribute to later adult car-
humans and non-human primates. Dr. Jason Gien stud-
diovascular disease; delivery room management of the
ies pulmonary hypertension, chronic lung disease, and
high-risk newborn; and medical education for pediatric
congenital heart disease. Dr. Theresa Grover focuses
residents. Dr. Laura Brown’s research goals are to inves-
on regulation of fetal and neonatal pulmonary blood
tigate how the intrauterine growth-restricted (IUGR)
flow, mechanisms of pulmonary vascular and alveo-
fetus adapts to conditions of nutrient restriction due
lar growth, persistent pulmonary hypertension of the
to placental insufficiency and to determine the degree
newborn, bronchopulmonary dysplasia, and the role of
of permanence and/or plasticity of these adaptations.
vascular endothelial growth factor in lung development.
90 D e p a r t m e n t o f P e d i a t r i c s
sections
es on international child health, neonatal resuscitation,
and high-altitude physiology including cardiopulmonary
adaptation in infants at high altitude, acute mountain
sickness in children, and fetal and neonatal origins of
chronic mountain sickness. Dr. Thomas Parker’s scientific focus is on hormonal modulation of the developing fetal pulmonary circulation, the role of endogenous
nitric oxide in the developing lung circulation, the
myogenic response in the fetal and newborn pulmonary
circulation, the role of rho kinase in the modulation of
pulmonary vascular tone, and the use of inhaled nitric
oxide in treatment of persistent pulmonary hypertension of the newborn. Dr. Regina Reynolds’ research
Neonatology Front row, l - r: Jacob Friedman, Danielle Smith,
Tiffany Brown; Middle row, l - r: Theresa Grover, Linda Woodstock,
Jennifer Corwin, Bonnie Savone, Anusha Streubel, Ronda Martinez;
Back row, l - r: Carrie McCurdy, William Hay, Jr., Adam Rosenberg
interests include neonatal nutrition, neonatal nutrient
metabolism, growth and body composition of the neonate, especially the preterm infant and neonates with
congenital heart disease. Dr. Adam Rosenberg’s research
Dr. William Hay, Jr.’s basic research is supported by
focus is on the regulation of cerebral blood flow in the
NIH-funded grants to study various aspects of placental
fetus and neonate, surfactant replacement therapy, clini-
and fetal growth restriction, with specific attention to
cal management of birth asphyxia, and outcomes of
placental nutrient transfer and metabolism, fetal insulin
high-risk newborn term and preterm infants. He is also
secretion, and fetal insulin action. His research is aimed
the Director of the Pediatric Residency Program. Dr.
at understanding how disturbances in maternal nutrient
Paul Rozance is investigating the impact of fetal growth
supply to the placenta and fetus produce adaptations in
and nutrient restriction on the development and func-
fetal development that could underlie later life disorders
tion of the pancreatic beta-cells as well as other organ
such as obesity, insulin resistance, and diabetes. His
systems. He also is interested in developing interventions
clinical research through the TCH Clinical Translational
to reverse the detrimental effects of fetal growth restric-
Research Center focuses on early postnatal intravenous
tion. Dr. Daniel Satterwhite studies the developmental
nutrition of the extremely low birth weight infant,
regulation of cell growth and differentiation, growth
aimed at determining the optimal amount and mixture
factors, oncogenes, tumor suppressor genes, IUGR, and
of amino acids and energy supplies to promote early
metabolism. Dr. Elizabeth Thilo’s research focuses on
and optimal growth of body weight and composition in
early adrenal insufficiency in ELBW infants, and the
preterm infants to prevent postnatal growth restriction.
concept of relative adrenal insufficiency in critically ill
He is also a world expert in neonatal applications of
infants, including the possible beneficial effect of steroid
pulse oximetry to monitor blood oxygenation in new-
replacement therapy in sepsis syndrome in the term and
born infants. Dr. Peter Hulac’s interests are in prenatal
near-term infant. She is also interested in early new-
consultations with families whose fetus has challenging
born discharge for both term and premature infants;
diagnoses. He is also an expert in decision-making in
noninvasive monitoring techniques, especially pulse
acute care situations, particularly at the margins of via-
oximetry; hyperbilirubinemia and prevention of kernict-
bility. Dr. M. Douglas Jones, Jr.’s research interest is in
erus; newborn transition and the effects of altitude; and
graduate medical education. Dr. Susan Niermeyer focus-
pain management in the neonate. Dr. Stephanie Thorn’s
2006-2008 Departmental Report
91
sections
Neonatology Faculty
research interests primarily involve the fetal origins of
diabetes and obesity; fetal metabolism; intrauterine fetal
growth and fetal growth restriction; mammalian glucose
and lipid metabolism; and molecular endocrinology and
metabolism. Dr. Patti Thureen is investigating fetal and
neonatal nutrition; fetal and neonatal amino acid and
protein metabolism; neonatal energy expenditure, nutrient balance, and body composition; and stable isotope
methodology. Dr. Randy Wilkening’s research activities
include placental transfer and function; fetal metabolic
responses to placental dysfunction; and fetal organ blood
flow and metabolism.
Education
The Neonatal-Perinatal Medicine Fellowship Training
Program is sponsored by the University of Colorado
Denver and The Children’s Hospital. This is a three-year
postdoctoral training program in neonatal-perinatal
medicine and is approved by the Residency Review
Committee of the Accreditation Council for Graduate
Medical Education. The program is directed by Thomas
Parker, MD. Fellows are supervised by faculty within
the Section of Neonatology and the division of Perinatal
Medicine and Research. The program includes 12
months of clinical training with 21 months of research
activity. The program is primarily interested in helping
trainees develop successful careers, based on excellence
in research, scholarship, and clinical medicine. The
Section also trains pediatric residents and offers electives
to fourth-year medical students.
Highlights
Doug Jones was named the recipient of the 2008
n
Joseph W. St. Geme, Jr. Leadership Award by the
Federation of Pediatric Organizations.
Bill Hay is past President of the American Pediatric
n
Society.
Faculty
Randall B. Wilkening, MD•
Professor of Pediatrics
Section Head, Neonatology
Vice Chair, Clinical Practice
Russell V. Anthony, PhD•
Associate Professor of Pediatrics
Hill Professor of Animal
Biotechnology, Colorado State
University
James S. Barry, MD•
Assistant Professor of Pediatrics
Frederick C. Battaglia, MD•
Professor Emeritus of Pediatrics
Laura D. Brown, MD•+
Assistant Professor of Pediatrics
Jacob E. Friedman, PhD•+
Professor of Pediatrics, Biochemistry
and Molecular Genetics
Director, Molecular Biology Core
Labs for UCD Training Program
in Perinatal Medicine and Biology
Director, Core Lab for Perinatal
Emphasis Research Center Grant
Sharon I. Langendoerfer, MD**
Associate Professor of Pediatrics
Amy Macritchie, MD
Senior Instructor of Pediatrics
Carrie E. McCurdy, PhD
Assistant Professor of Pediatrics
Susan Niermeyer, MD
Professor of Pediatrics
Jan E. Paisley, MD
Senior Instructor of Pediatrics
Thomas A. Parker, MD*•
Associate Professor of Pediatrics
Director, Neonatal-Perinatal
Medicine Fellowship Training
Program
Director, Neonatal Education
Jason Gien, MD•
Assistant Professor of Pediatrics
Mizanoor Rahman, PhD
Research Instructor of Pediatrics
Theresa R. Grover, MD•*
Associate Professor of Pediatrics
Timothy Robert Hume
Regnault, PhD•
Adjoint Assistant Professor
of Pediatrics
Daniel M. Hall, MD
Associate Professor of Pediatrics
William W. Hay, Jr., MD•++
Professor of Pediatrics
Scientific Director, Perinatal
Research Center
Co-Director, Colorado Clinical
Translational Sciences Institute
Director, Child and Maternal
Health Research, Colorado
Clinical Translational Sciences
Institute
Regina M. Reynolds, MD
Assistant Professor of Pediatrics
Jacinto A. HernГЎndez, MD, MHA
Professor of Pediatrics
Danielle Smith, MD•
Senior Instructor of Pediatrics
Peter Hulac, MD
Senior Instructor of Pediatrics
Associate Faculty, Center for
Bioethics and Humanities
Medical Director, Fetal Concerns
Program, The Children’s Hospital
and University of Colorado
Hospital
Medical Director, Newborn Services,
Platte Valley Medical Center,
Brighton, Colorado
M. Douglas Jones, Jr., MD
Professor of Pediatrics
92 D e p a r t m e n t o f P e d i a t r i c s
John P. Kinsella, MD•*
Professor of Pediatrics
Director, The Children’s Hospital
Newborn ECMO Service
Director, Pediatric Medical Advisory
Group, Newborn/Young Child
Team, Flight for Life
Adam A. Rosenberg, MD•
Professor of Pediatrics
Director, Pediatric Residency
Program
Paul J. Rozance, MD•
Assistant Professor of Pediatrics
Daniel J. Satterwhite, MD
Senior Instructor of Pediatrics
Anusha H. Streubel, MD, MPH
Assistant Professor of Pediatrics
Elizabeth H. Thilo, MD
Associate Professor of Pediatrics
Chair, Resident Recruitment
and Selection Committee
Patti J. Thureen, MD++•+
Professor of Pediatrics
Co-Director, Child and Maternal
Health Research, Colorado Clinical
Translational Sciences Institute
James J. Woods, DO**
Senior Instructor of Pediatrics
sections
Lana Yoder, BS
Senior Instructor of Pediatrics
Program Coordinator, Colorado
High-Risk Maternity and Newborn
Program
Margaret Heerwagen
Graduate Student
Clinical Faculty
Nancy English, PhD, RN
Clinical Instructor of Pediatrics
Dan Loturco, MS
Professional Research Assistant
Fellows
Cassidy Delaney, MD (2007-2010)
Mackenzi Frost, MD (2005-2009)
Pastora Garcia-Jones, MD
(2006-2009)
Beena D. Kamath, MD, MPH
(2005-2009)
Jinny Lavezzi, MD (2008-2011)
Robert Rock, MD (2007-2010)
Susan Soto, MD (2008-2011)
Jen-Ruey Tang, MD (2005-2008)
Stephanie Thorn, PhD (2008-2009)
Hillary Tuttle, MD, PhD (2007-2010)
Amy Wood, MD (2009)
Rachel Wright, MD (2008-2011)
Erica Wymore, MD (2006-2009)
Research Staff
David Caprio, BA
Senior Professional Research
Assistant
Alex Cheung, PhD
Senior Professional Research
Assistant
Mahau Choudhury, PhD
Postdoctoral Fellow
Becky De La Houssaye, MS
Professional Research Assistant
Rachael Janssen, MS
Senior Professional Research
Assistant
Susan Moreland, MSN, NNP
Research Coordinator
Meghan O’Meara, BS
Melanie Reece, PhD
Senior Professional Research
Assistant
Nephrology l - r: Gary Lum, Melissa Cadnapaphornchai, Douglas Ford
Jann Rhodes, PhD
extensive experience in the treatment of kidney and relat-
Gates Roe, BA
ed diseases, renal replacement therapy, both hospital-
Stephanie Thorn, PhD
Postdoctoral Fellow
based outpatient hemodialysis and an equally proficient
Adele Tooley, BSN
Karen Trembler, BS
Senior Professional Research
Assistant
and unparalleled home-based peritoneal dialysis program
(for those children and families who medically qualify).
Inpatient responsibilities include direct care of kidney
patients and consultative services, as well as provision of
Pi-Ou (Nancy) Tseng, BS, MS
dialysis, both acute and chronic forms, and the medical
* Pediatric Heart Lung Center
management of the renal transplant recipient. The same
Faculty
**Denver Health Faculty
+
Intellectual and Developmental
Disabilities Research Center Faculty
+
Nutrition Faculty
++
TCH Clinical Translational
Research Center Faculty
• Medical Education Faculty
• Perinatal Research Center Faculty
services are available to outpatients. After-hours access
Lucia Dohnal, BA
Professional Research Assistant
Nephrology
Clinical Services
to renal clinical coordinators is available to all Kidney
Center patients. A nephrologist is always available to all
local and regional area physicians for phone consultation.
Renal transplant outcomes continue to improve, and
the transplant program has seen a consistent number of
successful transplants being performed annually. The Section
participates in a number of national collaborative studies that include the investigation of different forms of
immunosuppression therapy for transplantation and the
treatment of focal glomerulosclerosis and IgA nephropathy.
The Section of Nephrology operates The Kidney
Center at The Children’s Hospital, providing complete
Research
renal care to the children of Colorado and the Rocky
Faculty research interests encompass a broad range of
Mountain Region. Children are referred and followed
basic science and clinical topics in pediatric nephrology.
for a multitude of renal maladies, ranging from the mild
These projects currently include the study of several
and transient to complete kidney failure requiring dialy-
renal conditions, including renal salt and water han-
sis and kidney transplantation. Although advances in the
dling, autosomal dominant polycystic kidney disease
diagnosis and treatment of kidney diseases help to delay
(ADPKD), congenital nephrogenic diabetes insipidus
the onset of the need for dialysis, dialysis remains a life-
(NDI), growth failure in chronic kidney disease, neph-
sustaining necessity for many children. The Section has
rotic syndrome and focal segmental glomerulosclerosis,
provided renal service for more than 30 years and has
and pediatric renal transplantation.
2006-2008 Departmental Report
93
sections
Nephrology Faculty
All faculty members are involved in collaborative
research with pediatric surgery to examine immunosuppression regimens and outcomes in pediatric renal
transplantation.
Dr. Melissa Cadnapaphornchai’s research in ADPKD
includes studies on the management of hypertension
in children with ADPKD, a single center interventional
trial designed to assess the effect of pravastatin on renal
and cardiovascular disease progression in children with
ADPKD, and examination of the role of the angiopoeitin gene as a modifier of disease severity in ADPKD.
Dr. Cadnapaphornchai is also the principal investigator
for an international multicenter interventional trial of
new pharmacologic treatments for children with congenital nephrogenic diabetes insipidus. This project is complemented in the laboratory by basic science studies of
Faculty
Gary M. Lum, MD
Professor of Pediatrics and Medicine
Section Head, Nephrology
Medical Director, The Kidney Center
Medical Director, Acute and
In-Center Hemodialysis Program
Melissa A. Cadnapaphornchai, MD
Associate Professor of Pediatrics
and Medicine
Director of Pediatric Research,
UCD Polycystic Kidney Disease
Research Group
Clinical Staff
Terri Bisio, RN, BSN, CNN
Barbara Cometti, RN, MA
Karen Davidson, MSW
Anna Finger, RN, ADN
Richard Gonzales, RN, BSN
Tanya Lenahan, RN, BSN
Silvia McKennon, RN, CNN
Leslie Montoya, RN, ADN
Laurel L. More, RN, BSN
Mary Schoenbein, RN, BSN
Suzan Stephens, RN, BSN
John Willoughby, CHT
Rose Woloschuk, RD
Douglas M. Ford, MD
Professor of Pediatrics
Medical Director, Home
Dialysis Program
Medical Director, Kidney
Center Transplant Program
Co-Chair, COMIRB
the mechanisms of renal salt and water handling in vari-
Nutrition
ous disease states. Dr. Cadnapaphornchai also collabo-
Clinical Services
rates with colleagues from the adult nephrology division
The Nutrition Department at The Children’s Hospital,
in the study of urinary markers to predict acute kidney
co-directed by Nancy F. Krebs, MD, and Jean Ann
injury in children undergoing cardiopulmonary bypass.
Olds, MS, RD, provides a comprehensive range of clini-
Dr. Douglas Ford is involved in research ethics, com-
cal nutrition support. Inpatient nutrition consultations
pliance, and oversight as a Co-Chair for the Colorado
are available for all levels of clinical complexity, with
Multiple Institutional Review Board of the University of
expertise available from physicians who are board certi-
Colorado Denver. Dr. Gary Lum is involved in collab-
fied in clinical nutrition, pediatric registered dietitians,
orative studies with the North American Pediatric Renal
and dietitian assistants.
Transplant Cooperative Study to examine the effect of
Outpatient clinics include the Growth and Parenting/
growth hormone treatment in children with chronic
Nutrition Clinic, which is a referral clinic for infants
renal insufficiency.
and children with growth and feeding problems, including failure to thrive, tube feedings, and other nutrition
Education
problems. A multidisciplinary pediatric weight-manage-
The Section of Nephrology offers clinical electives
ment clinic, the Good LIFE Clinic (Lifestyles Influencing
for residents at any level. The patients in The Kidney
Fitness and Eating), serves the medical needs of families
Center offer exposure to the management of dialysis,
with obese children, especially those with associated
renal transplant, and ambulatory outpatient nephrol-
medical complications. Both of these clinics serve as
ogy patients. The elective is open to fourth-year medical
education and training sites for housestaff, medical
students as well, including externs approved through
students, and nutrition fellows and are also linked to
Medical Education. The faculty also participates in com-
research protocols and clinical trials.
munity outreach and provides continuing medical education for clinicians in the region.
Many multidisciplinary programs, including cystic
fibrosis, gastrointestinal and liver disease, eating disorders,
metabolic disorders, renal disease, HIV, bone marrow
94 D e p a r t m e n t o f P e d i a t r i c s
sections
Dr. Richard Boles is a clinical psychologist who
joined the faculty in 2008 whose career goal is to lead
the development of innovative behavioral interventions
to improve early childhood dietary intake, physical
activity, and health outcomes in preschool children
with obesity. His previous research involved the study
of parental feeding practices and treatment of obesity
among preschool children, including the incorporation
of home visits into research and treatment strategies.
Dr. Paul Fennessey has interests and experience in the
Nutrition Front row, l - r: Nancy Krebs, Teresa Sharp, Richard Boles;
Back row, l - r: Susan Johnson, Michael Hambidge, Janine Higgins,
Catherine Romaniello, Velma Parker
development of analytical and biochemical techniques
transplantation and oncology, teen mothers, neurology,
basic nutritional questions. Dr. K. Michael Hambidge’s
and developmental disorders, incorporate dietitians and
research interest is directed towards human micronutri-
diet assistants as active members of their teams.
ent research. The broad goal of his research is to achieve
that use stable isotopes, in vitro and in vivo models, and
improved mass spectrometric capabilities to investigate
an adequate understanding of the causes and effects of
Research
zinc deficiency, with a special emphasis on a broad range
The faculty members of the Section of Nutrition have
of efficacy trials to determine effective, sustainable strate-
broadly based research interests in human and basic
gies, including biofortification, for the prevention of zinc
nutrition. Areas of particular focus include micronu-
deficiency. His research is conducted in several interna-
trients, especially trace mineral nutrition and bioavail-
tional settings, including Ethiopia, China, Guatemala,
ability, with emphasis in pediatric populations and
and other developing countries. Dr. Janine Higgins
women during the reproductive cycle in both the U.S.
researches the metabolic effect of resistant starch and
and in developing countries; mineral metabolism in
its effects on insulin sensitivity, fat oxidation, weight
normal infants (breastfed and formula-fed) and those
regain after weight loss, and hunger. Her collaborative
with pathologic conditions, e.g., cystic fibrosis or pre-
research investigates the metabolic problems that lead
maturity; obesity, adult and pediatric; energy balance
to weight regain in obese rats and humans. She is also a
and metabolism, especially in relation to exercise and
co-investigator in a multicenter national trial to define
gender-specific issues; interaction of diet, obesity, and
the most effective treatment for children with type 2
exercise on the development of cardiovascular disease
diabetes. Dr. James Hill’s research in the obesity field
and diabetes risk in children, energy intake regulation,
involves the study of lifestyle factors that affect body
and eating behavior, particularly in children; and the
weight regulation. In particular, he is interested in how
impact of community-based prevention programs in
diet and physical activity influence body weight and
elementary schools.
how high-fat diet and inactivity may contribute to the
The Colorado Clinical Nutrition Research Unit,
current global epidemic of obesity. Dr. Susan Johnson’s
(CNRU), funded by the NIH, is directed by James O.
research focuses on the development of children’s eating
Hill, PhD, and provides support for young investigators
behaviors and weight outcomes and the impact of the
and for core facilities including metabolic, energy balance,
mealtime environment upon children’s eating patterns.
and mass spectrometry. The administrative core includes
A recent focus includes the nutrient and food intake pat-
statistical expertise as well as CNRU administrative support.
terns of children with neurodevelopmental disabilities.
2006-2008 Departmental Report
95
sections
Her goal is to develop research-based clinical, consumer,
parent advocacy groups’ efforts to increase fruit/vegeta-
and community education and prevention programs in
ble availability/affordability in low-income communities.
the area of early childhood nutrition. These programs
Dr. Teresa Sharp’s research interests involve evaluation
will provide knowledge and opportunities for learning
of the interactions of physical activity, dietary influ-
for students in nutrition and early childhood education,
ences, and social determinants on pediatric obesity and
and for health care providers, parents, and caregivers.
long-term health outcomes. Specifically, significant focus
Dr. Nancy Krebs’ primary research interest is in trace
is placed on the impacts of obesity, ethnicity, and family
element nutrition in the infant and growing child and
history of chronic disease on lipid metabolism, insulin
during the reproductive cycle. Current research involves
action, vascular burden, and endothelial function in pre-
use of stable isotopes to study whole body zinc metabo-
and early-pubertal children. Dr. Patti Thureen is a neo-
lism and dietary requirements in normal adults and
natologist whose research focuses on nutrition support
infants. Her current work investigates optimal comple-
of the premature infant, including interventions to sup-
mentary feeding strategies for older breastfed infants
port optimal growth during the NICU stay. She applies
both in Denver and international settings. She is the
stable isotope methodology and uses indirect calorimetry
lead investigator for a cluster-randomized efficacy trial
and state-of-the-art body composition measurements to
of complementary feeding in four developing coun-
evaluate the effects of nutritional interventions.
tries through the NIH-supported Global Network for
Women’s and Children’s Health Research. A secondary
Education
area of interest is childhood obesity, the impact of early
Our faculty are dedicated to educating and training
feeding, and interventions in the primary and tertiary
pediatricians and researchers in an effort to continuous-
care settings to better identify, prevent, and treat obe-
ly produce well-trained scientists that will significantly
sity. Dr. Sian Lei’s research interests involve specialized
contribute to health-related research.
training and expertise in the operation of an inductively
We have a long-standing commitment to teaching
coupled plasma mass spectrometer. He has developed a
clinical nutrition to all levels of clinical trainees, includ-
methodology for both elemental and isotope ratio analy-
ing medical students, physician assistants, residents, and
ses of several mineral elements. Catherine Romaniello,
faculty. This includes approximately 15 hours of nutri-
MPH, RD’s interest is to improve the health of low-
tion lectures in the core pre-clinical medical school cur-
income families throughout Colorado, through school-
riculum, core content in the pediatric clerkship, and two
based, experiential nutrition education programs aimed
clinical electives, which are taken by approximately one
at increasing consumption of fruits and vegetables. Her
third of the fourth-year medical students.
programs reach approximately 28,000 elementary
We currently have a two- to three-year nutrition
school-aged children and their families each year in
postdoctoral fellowship training program, supported
18 school districts across the state. Current research
by an NIH-T32 postdoctoral training grant. For physi-
is focused on the nutritional behavioral impacts of:
cians who desire training in clinical nutrition, either as a
1) classroom-based lessons using food preparation; 2)
subspecialty or as an area of focus within another sub-
cafeteria-based enhancements to classroom instruction;
specialty (e.g., endocrinology, gastroenterology, primary
3) Web-based nutrition education among monolingual
care), the research fellowship may be preceded by a six-
parents; 4) second grade take-home book bag program;
to twelve-month clinical training program, tailored to
5) small-group bilingual parent education classes; and 6)
the individual’s interests and strengths.
96 D e p a r t m e n t o f P e d i a t r i c s
sections
Nutrition Faculty
Faculty
Nancy F. Krebs, MD+•
Professor of Pediatrics
Section Head, Nutrition
Chair, Department of Pediatrics
Promotions Committee
Richard E. Boles, PhD
Assistant Professor of Pediatrics
Paul V. Fennessey, PhD**+++
Professor of Pediatrics and
Pharmacology
Vice Chair, Research
K. Michael Hambidge, MD, ScD+
Professor Emeritus of Pediatrics
Janine A. Higgins, PhD++
Assistant Professor of Pediatrics
James O. Hill, PhD••
Professor of Pediatrics
Director, Center for Human Nutrition
Director, Colorado Clinical Nutrition
Research Unit
Susan L. Johnson, PhD+
Associate Professor of Pediatrics
Director, The Children’s Eating Lab
Sian Lei, MD, PhD
Instructor of Pediatrics
Renee Porter, RN, CPNP
Instructor of Pediatrics
TCH Obesity Program Coordinator
Catherine Romaniello, MPH, RD
Senior Instructor of Pediatrics
Teresa A. Sharp, PhD
Assistant Professor of Pediatrics
Xiaoyang Sheng, MD, PhD
Visiting Professor
Patti J. Thureen, MD*++•
Professor of Pediatrics
Clinical Faculty
Marianne Neifert, MD
Clinical Professor of Pediatrics
Adjunct Faculty – Colorado State
University
G. D. Kenneth Allen, PhD
Jennifer E.L Anderson, PhD
Christopher L. Melby, DrPH
Michael J. Pagliassotti, PhD
Clinical Staff
Jean Ann Olds, MS, RD
Clinical Nutrition Manager
Nutrition Fellows
Matthew A. Haemer, MD
Christopher L. Gentile, PhD
Erin Sundeth Ross, PhD, CCC-SLP
Research Associates
Julie Atwood, MNM
Sara Desmond, BA
Diana Culbertson, MS, RD
Cherith Gordon, BA
Adrienn Albert Hollonds, MPH
Leland V. Miller, BS
Laura Primak, RD
Julie A. Sanchez, BS
Sarah A. Stotz, MS
Robyn Wearner, BS, RD
Jamie L. Westcott, MS
* Neonatology Faculty
**Children’s Outcomes Research
Program Faculty
+
Intellectual and Developmental
Disabilities Research Center Faculty
+
TCH Research Institute Faculty
+
Clinical Genetics and Metabolism
Faculty
++
TCH Clinical Translational
Research Center Faculty
• Perinatal Research Center Faculty
• Center for Human Nutrition
Faculty
• Clinical Nutrition Research
Unit Faculty
Paula Pierce, PhD, RN
Assistant Clinical Professor
of Pediatrics
Pediatric Hospital Medicine Front row, l - r: Rachel Workman,
Jennifer Reese, Ann Boyer, Leigh Anne Baker, Amy Tyler; Back row, l - r:
Mark Brittan, Julie Noffsinger, David Fox, Marla Laufer, Meegan Leve
campus, as well as at our Network of Care (NOC)
inpatient sites, including Exempla Lutheran Medical
Center, The Children’s Hospital at Saint Joseph
Hospital, and The Children’s Hospital at Parker
Adventist Hospital.
Our focus is on the care of the hospitalized child.
Our staff are general pediatricians with a clinical
interest in inpatient medicine. One of our new faculty
members, L. Barry Seltz, is fellowship-trained in pediatric hospital medicine. We prioritize seamless communication with patients and families, with a focus on
family-centered care, as well as with referring primary
care providers and consulting services.
We also provide medical support for the Patient
Placement Department, by providing 24 hours a day,
7 days a week phone availability to facilitate direct
admissions to the TCH main campus and NOC sites.
Our hospitalists are all credentialed in sedation
services and we provide procedural sedation for our
patients on the wards and in the procedure center.
We have also collaborated successfully with the
Pediatric Hospital Medicine
Department of Orthopedics to provide hospital co-
Clinical Services
management of high-risk orthopedic patients who
The Section of Pediatric Hospital Medicine provides
require medical management for complex medical
inpatient services to hospitalized patients with gen-
conditions during their postoperative hospital stay.
eral pediatric conditions. We have faculty who care
We hope to expand this service to co-management
for inpatients at the main Children’s Hospital (TCH)
with other surgical services at TCH.
2006-2008 Departmental Report
97
sections
Network of Care Front row, l - r: Priti Laselle, Amy Tyler, Marla Laufer, Rachel Workman, Leigh Anne Bakel, Carey Seatter, Angela Zang;
Middle row, l - r: Susan Smith, BreAnn Behlen, Derrek Massanari, Janette Prokop, Rachel Fortune, Ann Van Horne; Back row, l - r: Karin Klee,
Christine Walravens, Trista Bowyer, Danute Strepman, Jeffrey Brown, Krista York
Research
professionalism and interdisciplinary communication
Dr. Daniel Hyman investigates issues of quality and
skills, and supporting their educational focus on sys-
patient safety. Dr. Julie Noffsinger focuses on pediatric
tems-based practice and practice-based learning. We also
resident and medical student education. Dr. Jennifer
focus on the education of medical students (both visiting
Reese’s research interests are pediatric early warning
and from UCD) and physician assistant students during
signs as a predictor of deteriorating patients and appro-
their clinical rotations on our services. We have a spe-
priate patient placement, reducing unplanned ICU
cial opportunity to work closely with family medicine
transfers, SIDS prevention, and programs for resident
residents from St. Anthony’s Family Medicine Residency
support. Dr. Barry Seltz’s research interests are global
Program, University of Colorado Denver, University of
medicine, pediatric resident and medical student educa-
Washington Family Medicine Residency Program, and
tion, and febrile seizures and meningoencephalitis.
Exempla Saint Joseph Hospital.
Education
Highlights
Our hospitalists have a strong presence in the education
n
Daniel Hyman has recently joined TCH as Chief
Quality Officer.
of medical students, residents, and physician assistant
students who rotate on the wards at TCH and NOC
Rachel Workman has established The Center
n
sites. We supervise pediatric and family medicine resi-
for Integrative Medicine at TCH and is its new
dents on the wards, providing general pediatric educa-
Medical Director.
tion and support of clinical decision-making, modeling
98 D e p a r t m e n t o f P e d i a t r i c s
sections
Pediatric Hospital Medicine Faculty
Faculty
Jennifer Reese, MD
Senior Instructor of Pediatrics
Interim Section Head, Pediatric
Hospital Medicine
Director, Inpatient Medicine,
The Children’s Hospital
D. David Scudamore, MD
Senior Instructor of Pediatrics
Medical Director, The Children’s
Hospitalist Group at Exempla
Lutheran Medical Center, The
Children’s Hospital at Saint
Joseph Hospital, and The
Children’s Hospital at Parker
Adventist Hospital
Mark Brittan, MD
Senior Instructor of Pediatrics
Daniel Hyman, MD, MMM
Assistant Professor of Pediatrics
Chief Quality Officer, The Children’s
Hospital
Jennifer M. Kozel, MD
Instructor of Pediatrics
Marla Laufer, MD
Senior Instructor of Pediatrics
Tiera Nell, MD
Senior Instructor of Pediatrics
Julie Noffsinger, MD•
Assistant Professor of Pediatrics
Assistant Director, Clinical Clerkship
in Infant, Child and Adolescent
Care
Stacey Wall, PNP
Senior Instructor of Pediatrics
Rachel Workman, MD, FAAP
Senior Instructor of Pediatrics
Medical Director, The Center
for Integrative Medicine at
The Children’s Hospital
Leigh Anne Bakel, MD
Senior Instructor of Pediatrics
Amy Tyler, MD
Senior Instructor of Pediatrics
L. Barry Seltz, MD
Assistant Professor of Pediatrics
Clinical Faculty
Monique Twite, CPNP
Clinical Instructor of Pediatrics
•
Medical Education Faculty
Meegan Leve, MD
Senior Instructor of Pediatrics
Prevention Research Center
for Family and Child Health
Prevention Research Center for Family and Child Health
Front row, l - r: Dennis Luckey, David Olds, Michael Knudtson,
John Holmberg; Middle row, l - r: Robin Tutt, Erin Ingoldsby,
Wendy Gehring, Francesca Pinto; Back row, l - r: LaShona Lewis,
Nancy Donelan-McCall, Joan Deming, Kim Weber Yorga
In recent years, the PRC has begun a process of careful replication of the nurse home visiting program tested
in these trials (now called the Nurse-Family Partnership
program) in an effort to make the services available to
a large portion of low-income pregnant women in the
U.S. The national replication of the program is managed
by a nonprofit organization known as the Nurse-Family
Clinical Services
Partnership (NFP). The NFP National Service Office
A major focus of the Prevention Research Center for
helps communities develop their capacity to imple-
Family and Child Health (PRC) is on the examination
ment the program and provides training and technical
of the long-term impact of a program of prenatal and
assistance to nurses who deliver the services. The PRC
infancy home visiting by nurses on the health and devel-
is now conducting research aimed at improving the
opment of low-income, first-time mothers and their
NFP program model with the use of randomized, con-
families, who have participated in a series of random-
trolled trials of augmented versions of the NFP model.
ized controlled trials of this intervention. With fund-
Investigators are examining ways to help nurses deal
ing from the NIH, other federal agencies, and private
more effectively with maternal mental illness, intimate
philanthropies, longitudinal follow-ups of this program
partner violence, the involvement of fathers, helping
are being conducted in Elmira, New York; Memphis,
parents care competently for their children, and more
Tennessee; and Denver, Colorado. These studies exam-
fully engaging program participants.
ine program effects on maternal economic self-sufficien-
The PRC is also recognized for its periodic reviews of
cy, substance abuse, and children’s adaptive function-
early intervention literature; its support of early inter-
ing, including mental health, criminal behavior, and
vention programs wishing to improve their effectiveness;
productive life course as the children reach adolescence
its consultation with government and private agencies;
and young adulthood.
and its training of prevention scientists.
2006-2008 Departmental Report
99
sections
Research
systems perspective. Dr. David Olds is interested in
The PRC is currently conducting follow-up studies of
developing and testing interventions designed to improve
participants in three randomized controlled trials of a
maternal and child health early in the lives of children.
program of prenatal and infancy home visitation by
nurses known as the Nurse Family Partnership (NFP).
We also are beginning a series of new trials that will
Education
The PRC serves as a training site for graduate students,
test augmentations of the NFP as it is being replicated in
postdoctoral fellows, and other scholars seeking to deep-
hundreds of communities across the nation.
en their training or experience in prevention science and
A growing focus of the PRC involves international
the evaluation of program dissemination efforts. In addi-
work. In 2004, the PRC began responding to inquiries
tion, PRC staff and faculty are called upon frequently
from researchers and/or government health agencies
to present at conferences and meetings on topics which
abroad that were interested in possibly developing the
include research and evaluation design and measurement
Nurse-Family Partnership program in their country. This
in prevention; clinical aspects of effective home-based
work involves helping international partners adapt and
family intervention programs; and challenges in program
test the NFP in other societies.
dissemination.
Finally, we have begun a new program of research
focused on adapting the NFP program content and
Highlights
methods for group-based prenatal and well-child care.
n
David Olds was given the third Stockholm Prize in
This work is being carried out in its first phases in col-
Criminology from the Swedish Ministry of Justice for
laboration with investigators and staff who conduct the
his field experiments in policies for crime and injury
Colorado Adolescent Maternity Program.
prevention. This international prize was established
Joan Deming, MAS, has worked in early childhood
in 2006 and is awarded for outstanding achievements
development research for 26 years. She is particularly
in criminological research or for the application of
interested in parenting, resiliency, and cultural issues, as
research results by practitioners for the reduction of
well as the dissemination of research outcomes and their
crime and the advancement of human rights.
impact on public policy. Dr. Nancy Donelan-McCall’s
interests include the development and testing of assessment measures and intervention methods designed to
promote competent parenting for at-risk parents and
caregivers of young children. She is also interested in
the identification or risk and protective factors that
relate to competent parenting and child outcomes.
Dr. John Holmberg’s interests include child development
outcomes, child-friendly intervention strategies, prevention of psychopathology, and the unique developmentally-enhancing influence provided by fathers to their
children throughout the lifecycle. Dr. Erin Ingoldsby’s
interests are in improving child and family engagement
in evidence-based prevention and intervention programs.
Other research interests include understanding and
preventing child antisocial behavior from an ecological-
1 00 D e p a r t m e n t o f P e d i a t r i c s
Preventin Research Center Faculty
Faculty
David L. Olds, PhD
Professor of Pediatrics, Psychiatry
and Nursing
Professor of Community and
Behavioral Health, Colorado
School of Public Health
Director, Prevention Research
Center for Family and Child Health
Pilar R. Baca, RN, MSN
Clinical Director, Program
Development
Joan Keller Deming, MAS
International Program Coordinator
Nancy Donelan-McCall, PhD
Assistant Professor of Pediatrics
Wendy Gehring
Data Coordinator
John R. Holmberg, PsyD
Research Fellow
Erin Ingoldsby, PhD
Research Fellow
Michael D. Knudtson, MS
Researcher/Biostatistician
LaShona E. Lewis
Business Manager
Dennis W. Luckey, PhD
Research Associate of Biostatistics
and Informatics, Colorado School
of Public Health
Director, Data Operations and
Biostatistics
Francesca Pinto, MPH
Replication Project Manager
Robin Tutt
Trials Project Manager
Kim Weber Yorga, RN, BSN
Nurse Clinician
sections
Affiliated Faculty and Staff
University of Colorado Denver
Sherry S. Leonard, PhD
Associate Professor of Psychiatry
Marshall Thomas, MD
Associate Professor of Psychiatry
Jessica Bondy, MHA
Assistant Professor of Biostatistics
and Informatics, Colorado School
of Public Health
Jeannette Waxmonsky, PhD
Instructor of Psychiatry
Jeanelle Sheeder, MSPH
Instructor of Pediatrics
Karolyn Kabir, MD++
Assistant Professor of Pediatrics
Stephen Scott, MD
Assistant Professor of Obstetrics
and Gynecology
Christian Hopfer, MD
Associate Professor of Psychiatry
University of Colorado Boulder
Robin Corley, PhD
Senior Research Associate, Institute
for Behavioral Genetics
Terence Thornberry, PhD
Professor of Sociology, Institute
of Behavioral Science
Baylor University
Carole Hanks, DrPh, RN, FNP
Associate Professor of Nursing
Cornell University
John Eckenrode, PhD
Professor of Human Development
Charles R. Henderson, Jr.
Senior Research Associate
University of Rochester
Robert Cole, PhD
Associate Professor of Nursing
and Psychiatry
Harriet Kitzman, PhD, RN
Professor of Nursing
McMaster University
Harriet McMillan, MD
Director, Offord Centre for Child
Studies Advocacy and Assessment
Program
University of Chicago
James Heckman, PhD
Henry Schultz Distinguished Service
Professor of Economics
Pulmonology Front row, l - r: Carole Kline, Edith Zemanick,
Gwendolyn Kerby, Ruth Devoogd, Keith Cavanaugh; Back row, l - r:
Vivek Balasubramaniam, Frank Accurso, Christopher Baker,
Jeffrey Wagener, Robin Deterding
pulmonary function testing (in infants and children),
fiberoptic bronchoscopy and laryngoscopy (including
Yale University
James Leckman, MD
Neison Harris Professor of Child
Psychiatry and Pediatrics
lavage and transbronchial biopsy), induced sputum col-
Elena Grigorenko, PhD
Associate Professor, Child
Study Center
and high-resolution chest CT scanning. An experienced
++
tory therapists allows families to benefit from the team
Adolescent Medicine Faculty
Pulmonology
lection and evaluation, full sleep evaluation (including
polysomnography, video-assisted thoracoscopic surgery),
staff of nurses, dieticians, social workers, and respiraapproach to lung disease. The Section of Pulmonology
is committed to family-centered care; close collaboration
with referring physicians; and integration of teaching
and research in clinical care as appropriate.
Clinical Services
The Section of Pulmonology provides comprehen-
Research
sive clinical care and consultation for children with
The Pulmonology faculty participate in basic and clini-
lung disorders. Care is provided at The Children’s
cal research, examining the causes and treatments of
Hospital, National Jewish Health, and at outreach clin-
a wide range of pediatric pulmonary disorders. As a
ics in Colorado and Montana. Pulmonary care at The
national referral center, the Section of Pulmonology is
Children’s Hospital was ranked second in the nation
dedicated to providing professional education at all lev-
by Parents magazine in its 2008 survey. Special areas
els and is committed to advancing knowledge through
of expertise include asthma, airway abnormalities,
our comprehensive research programs. More than 35
bronchopulmonary dysplasia, pulmonary hyperten-
clinical research studies in pediatric pulmonary disorders
sion and vascular disease, apnea and sleep-disordered
are ongoing at any given time.
breathing, congenital anomalies of the lung, interstitial
Dr. Steven Abman, Director of the Pediatric Heart
lung disease, chronic ventilation in infants and chil-
Lung Center, is an internationally renowned investigator
dren, pediatric lung transplantation, and cystic fibro-
in a number of areas of pediatric pulmonology. He has
sis. Extensive diagnostic testing is available including
made important contributions to vascular biology and
2006-2008 Departmental Report
101
sections
growth and development of the lung through his basic
tion and asthma. Dr. Keith Cavanaugh’s research activi-
investigations. In addition, he has led important clinical
ties include working with the State of Colorado in the
research studies in pediatric pulmonary hypertension,
ongoing development of a program that will help health
bronchopulmonary dysplasia, and other disorders.
care providers address the risks of Second Hand Smoke
Dr. Abman’s pioneering work in the use of nitric oxide
Exposure (SHS) with their patients and motivate care-
to treat infants and children with pulmonary hyperten-
givers to decrease tobacco exposure to their children.
sion resulted in his receiving the prestigious Excellence in
Dr. Robin Deterding is internationally recognized for
Pediatric Research Award from the American Academy
her research in children with interstitial lung disease
of Pediatrics. Dr. Abman’s research is supported by the
(chILD), clinical studies in cystic fibrosis, and medical
NIH and other agencies. Dr. Frank Accurso is inter-
education. Her current clinical research focus includes
nationally known for his work with newborn screen-
interstitial lung disease, complex lung disease, and pul-
ing and the description of early lung disease in infants
monary complications of bone marrow transplant and
with cystic fibrosis. Following the selection of UCD as
connective tissue disease in children. She is a founding
one of the Cystic Fibrosis Foundation’s Therapeutics
member of the Children’s Interstitial Lung Disease
Development Centers, he has been increasingly active
(chILD) Foundation. Dr. Monica Federico heads the
in the development and study of new therapies and
outpatient asthma program to complement the inpatient
techniques for outcomes research. Dr. Accurso’s research
asthma pathway at The Children’s Hospital and is
is supported by the NIH and the Cystic Fibrosis
involved with several clinical studies involving outcomes
Foundation. Dr. Christopher Baker studies endothelial
research in asthma. Dr. Federico is also involved in the
progenitor cells and their role in normal pulmonary
care of Spanish-speaking children with pulmonary disease,
vascular development and lung disease. He is currently
including asthma and cystic fibrosis. Dr. Norman
analyzing these cells in umbilical cord blood samples
Friedman’s research interests include evaluating the
obtained from term and premature infants at birth.
peri-operative morbidity of sleep-disordered breathing
Dr. Baker is hopeful that further research in this area
in children as well as whether a parent’s personality
will lead to novel therapies for bronchopulmonary
profile can predict a child’s continuous positive airway
dysplasia, a chronic lung disease associated with prema-
pressure (CPAP) compliance. Dr. Ann Halbower is
turity. Clinically, Dr. Baker is interested in the care
nationally recognized for her research and clinical work
of preterm infants with lung disease and associated
in pediatric sleep disorders. Her current study, funded
cardiopulmonary disorders such as pulmonary hyper-
by the NIH, investigates the impact of childhood sleep-
tension. Dr. Baker’s research is supported by the
disordered breathing on learning, memory, and neuronal
NIH and the American Thoracic Society. Dr. Vivek
brain injury. She is initiating a Children’s Hospital-based
Balasubramaniam’s research interest is in the mecha-
community outreach program in prevention of sudden
nisms underlying lung vascular and alveolar develop-
unexpected death in infants. She is also teaming up with
ment, especially in response to stress and injury. His
obesity prevention teams at TCH and UCD to determine
focus is on the role of nitric oxide and other factors
the risk of the combined problems of obesity and sleep
in the growth and development of blood vessels in the
apnea and the effects of treatment. Dr. Halbower is
lung. His research holds the promise of helping infants
the Vice Chair of the Health Policy Committee at the
with disorders of lung development. Dr. Balasubramaniam’s
American Thoracic Society, which strives to change
research is supported by the NIH. Dr. Susan Brugman
legislation to improve sleep and respiratory disorders.
is based at National Jewish Health. She is a leading
Dr. J. Kirk Harris is investigating the role of the
expert in the care of children with vocal cord dysfunc-
microbiome in pediatric pulmonary disease. His work is
1 02 D e p a r t m e n t o f P e d i a t r i c s
sections
funded through the Cystic Fibrosis Foundation and the
how cells are injured by oxidants and the preventive
NIH. Dr. Gwendolyn Kerby has developed the infant
benefit of antioxidants and other protective interventions.
pulmonary function testing laboratory and is active in
Dr. Edith Zemanick’s research interest is airway infection
several clinical studies involving young children with
in children with cystic fibrosis. She is currently funded by
cystic fibrosis, asthma, bronchopulmonary dysplasia,
the Cystic Fibrosis Foundation to study molecular detec-
and pulmonary hypertension. Dr. Kerby’s research
tion of polymicrobial infection in cystic fibrosis. She has
is supported through the NIH, the Cystic Fibrosis
several ongoing clinical research projects supported by
Foundation, and the State of Colorado. Dr. Marzena
the Colorado Clinical Translational Sciences Institute.
Krawiec, based at National Jewish Health, is a leading
clinical investigator in asthma. She participates in several
Education
asthma networks through the NIH. Dr. Gary Larsen,
The Pulmonology Section is firmly committed to the
based at National Jewish Health, is internationally rec-
education and mentorship of medical students, pediatric
ognized for his research into the basic causes of asthma.
residents, and pulmonology fellows. Our three year,
Additionally, he is currently involved as one of the
ACGME-accredited fellowship in pediatric pulmonology
directors of several multicenter national studies looking
provides unparalleled clinical experience with diverse,
at therapeutic options for children with asthma. He has
structured research opportunities. Almost all graduates
participated in several NIH study groups and remains
of our program take academic positions. Many have
actively involved with setting national goals for asthma
obtained leadership positions nationally in a variety of
research. Dr. Scott Sagel is nationally recognized for his
different areas. A sleep medicine fellowship is also avail-
clinical research involving children with cystic fibrosis
able. All faculty members are involved in the education
and primary ciliary dyskinesia. He is funded by the NIH
of fellows and residents. Members of the Section par-
and the Cystic Fibrosis Foundation to study biomarkers
ticipate in teaching medical students on the pulmonary
of airway inflammation and injury in children with these
inpatient service and outpatient clinics. Fourth-year
conditions. He chairs the Induced Sputum/Inflammatory
medical students can take a fourth-year elective on the
Biomarkers Working Group for the Cystic Fibrosis
pediatric pulmonary service.
Foundation’s Therapeutics Development Network
and he is Associate Director of the Pediatric Cystic
Highlights
Fibrosis Center. Dr. Jeffrey Wagener is the Pulmonology
n
Steve Abman led a National Heart Lung and Blood
Fellowship Director. His research activities primarily
Institute conference on future research in pediatric
involve the epidemiology of cystic fibrosis. As a member
respiratory disease. This has recently been published
of the North American Scientific Advisory Group for the
in Proceedings of the American Thoracic Society and
Epidemiologic Study for Cystic Fibrosis, he is involved
Pediatric Pulmonology. Dr. Frank Accurso also par-
with many projects identifying associations between
ticipated in the conference.
treatments and outcomes in cystic fibrosis. Additionally,
Jeffrey Wagener received the Outstanding Clinician of
n
the Year Award from the American Thoracic Society.
he is interested in quality improvement as a research
tool to change outcomes for patients with cystic fibrosis.
Scott Sagel received the first National Quality
n
Dr. Carl White, who is based at National Jewish Health,
Improvement Award from the Cystic Fibrosis
is a world leader in the study of oxidant-mediated lung
Foundation for his work on developing a family
injury in humans. Having developed several animal and
council to improve CF care.
cell culture models for lung injury, he has extended his
studies from “the bench to the bedside” by looking at
Frank Accurso received the Breath of Life Award
n
from the local Cystic Fibrosis Foundation.
2006-2008 Departmental Report
103
sections
Pulmonology Faculty
Faculty
Frank J. Accurso, MD++
Professor of Pediatrics
Section Head, Pulmonology
Director, Cystic Fibrosis Center
Medical Director, Core Laboratory,
TCH Clinical Translational
Research Center
Steven H. Abman, MD*•
Professor of Pediatrics
Director, Pediatric Heart Lung
Center
Christopher D. Baker, MD*
Assistant Professor of Pediatrics
Vivek Balasubramaniam, MD*•
Associate Professor of Pediatrics
Director, Pediatric Heart Lung
Center Laboratory
Associate Director, Pediatric
Pulmonology Fellowship
Program
Susan M. Brugman, MD**
Associate Professor of Pediatrics
Keith L. Cavanaugh, MD++
Assistant Professor of Pediatrics
Associate Director, The Children’s
Hospital Sleep Center
Robin R. Deterding, MD•
Professor of Pediatrics
Associate Dean, Clinical Curriculum,
School of Medicine
Director, Breathing Center
Director, Children’s Interstitial
Lung Disease (ChILD) Program
Ruth DeVoogd, RN, MSN, CPNP
Senior Instructor of Pediatrics
Monica Jones Federico, MD
Assistant Professor of Pediatrics
Associate Director, Asthma Program
Norman Friedman, MD++
Associate Professor of
Otolaryngology and Pediatrics
Director, The Children’s Hospital
Sleep Center
++
Ann C. Halbower, MD
Associate Professor of Pediatrics
Director, Pediatric Sleep Research
Kirk C. Hansen, PhD
Research Assistant Professor
of Pediatrics
Jonathan Kirk Harris, PhD
Research Instructor of Pediatrics
Research Instructor of Biostatistics
and Informatics, Colorado School
of Public Health
Gwendolyn S. Kerby, MD
Associate Professor of Pediatrics
Director, Pulmonology Clinical
Programs
Director, Asthma Program
Director, Pulmonology Diagnostics
Center
Carole E. Kline, MSN, CPNP++
Senior Instructor of Pediatrics
Marzena E. Krawiec, MD**
Associate Professor of Pediatrics
Gary L. Larsen, MD**
Professor of Pediatrics
Renee Rietsch, MSN, CPNP*
Instructor of Pediatrics
Scott D. Sagel, MD
Associate Professor of Pediatrics
Associate Director, Cystic Fibrosis
Center
Heidi Kaess, BS
James E. Shira, MD
Professor Emeritus
Lisa Monchil, RRT
Marci K. Sontag, PhD
Assistant Professor of Epidemiology,
Colorado School of Public Health
Jeffrey S. Wagener, MD
Professor of Pediatrics
Director, Pediatric Pulmonology
Fellowship Program
Brandie Wagner, PhD
Research Instructor of Biostatistics
and Informatics, Colorado School
of Public Health
Carl W. White, MD**
Professor of Pediatrics
Edith Zemanick, MD
Assistant Professor of Pediatrics
Fellows
Casey Burg, MD (2008-2011)
Marc Chester, MD (2006-2009)
Jerimiah Lysinger, MD (2005-2008)
Tod Olin, MD (2008-2011)
Jon Popler, MD (2007-2010)
Livia Veress, MD (2001-2010)
Research Staff
Meg Anthony, MSW
Leanne Arbuthnot, BS
Janna Arend, BS
Jill Hammond, RN
Shelley Mann, RN
Gloria Martin, RN
Churee Pardee, RN, MSN
Mark Stevens, PhD
Professional Research Assistant
Elinor Towler, BA
Wendy Walmsley, MA
Clinical Staff
Rosalie Bush, RN, MSN
Roberta Cox, RRT
Janice Fordyce, RD
Alicia Hanes, RN
Stacy Koczara, RRT
Carol Kopecky, RRT
Christina Leone, MSW
Cathy Lingard, RD, CNSD
Megan McDowell, MSW
Sally Mescher Allen, RN
Julia Micalizzi, RN
Laura Muenstermann, RN
Donna Parker, RRT
Kathy Spomer, RN
Gina Urbine, RN
Erin Wells, RN
Administrative Staff
Kendra Burghardt
Elizabeth Bekele, MS
Diane Herrick, RRT
Rand Hooks
Robin Mascotti
Celia Tunson
Mary Watson, BA
Management Staff
Juanita J. Kennedy, BS
Kathy Ryan Morgan
* Pediatric Heart Lung Center
Faculty
**National Jewish Health Faculty
++
The Children’s Hospital Sleep
Center Faculty
++
TCH Clinical Translational
Research Center Faculty
• Medical Education Faculty
• Perinatal Research Center Faculty
Outpatient Pavilion Waiting Room, The Children’s Hospital
1 04 D e p a r t m e n t o f P e d i a t r i c s
programs
Center for Bioengineering
Program Overview
The Center for Bioengineering is part of the School of
Medicine at the University of Colorado Denver and is
housed on the Anschutz Medical Campus to facilitate
interdisciplinary work in engineering and medicine.
The Center supports bioengineering discovery, translation, and commercialization by promoting bioengineering research and training initiatives on and across
all University of Colorado campuses and in collaboration
with local hospitals, laboratories, and industry.
The Children’s Hospital and other Center for
Bioengineering affiliates work closely with Center staff
to conduct research and testing in support of materials,
device, imaging, and modeling advancements.
Funding for the Center is provided by grants, donations,
Center for Bioengineering l - r: Wei Tan, Kendall Hunter, Craig Lanning,
Timothy Scott, Robin Shandas
Center, from graduate student training through faculty
research.
Faculty within the Center are involved with several
multidisciplinary clinical research projects in the area of
pulmonary vascular disease, including the development
and contributions from the University of Colorado at
of novel diagnostics and patient-specific hemodynamic
Boulder College of Engineering and Applied Science, as
simulation techniques to better understand pulmonary
well as the UCD School of Medicine and its Departments
hypertension in children. Strong interactions with clini-
of Pediatrics and Surgery.
cal and basic science faculty have also led to the inven-
The Center’s training initiatives include the introduc-
tion of several technologies, including a novel artificial
tion of bioengineering master’s and doctoral degree pro-
right ventricle to support children with congenital
grams by fall 2010. The Center staff is currently work-
heart disease, new shape memory polymers for next-
ing closely with faculty and administrators in the School
generation minimally-invasive medical devices, and Echo
of Medicine and the College of Engineering and Applied
Particle Image Velocimetry (Echo PIV) to obtain details
Science to realize this goal.
of blood flow using noninvasive approaches. These
efforts have led to the formation of several start-up
Research
companies. The Center also acts as a resource to faculty
The Center for Bioengineering supports bioengineering
interested in designing, prototyping, testing, and bench-
research and training at the University of Colorado.
marking new medical device and technology ideas.
Center faculty and staff involved with the Department
Dr. Kendall Hunter’s research centers on the use of
of Pediatrics have long-standing research programs
computational mechanics to model patient-specific car-
around the application of cutting-edge technologies
diac interventions and novel medical devices. Dr. Hunter
and engineering methods to solve current clinical prob-
also works extensively in the field of noninvasive imag-
lems. Faculty have expertise in novel biomaterials and
ing and computer-predicted outcomes. Craig Lanning,
biomedical devices, advanced imaging, computational
BS, conducts research involving medical image process-
simulations, and experimental diagnostics at multiple
ing with an emphasis on three-dimensional cardiac mor-
dimensional scales. Strong focus is placed on not only
phology, state-of-the-art in vitro modeling, and proof-
developing technologies and tools but also translating
of-concept characterization of novel medical devices.
these into clinical use. Translational bioengineering
Dr. Timothy Scott’s research is focused on developing
is in fact a fundamental theme for all aspects of the
polymer networks with novel material properties for
2006-2008 Departmental Report
105
programs
biomedical applications. Dr. Robin Shandas’ research is
focused on state-of-the-art noninvasive medical imaging
systems and clinical translations. Dr. Wei Tan’s research
involves characterization of arterial stiffening on vascular disease, bionanomaterials for vascular tissue engineering, and developing a nanoscale funcationalization
platform for highly selective and sensitive biosensing.
Center for Human Nutrition
Program Overview
The Center for Human Nutrition (CHN) is an interdisciplinary team encompassing basic and clinical
research, postgraduate training and career development
of nutrition professionals, and community outreach.
The research conducted at the CHN focuses on obesity
prevention and treatment and nutrient metabolism. The
Education
The Center for Bioengineering currently has a doctoral
and postdoctoral training program in cardiovascular
mechanics and imaging. The program provides a highly
interdisciplinary training environment that combines
advanced engineering training in mechanics, fluid
dynamics, materials, and/or transport with in-depth
exposure to clinical cardiovascular research and diag-
community outreach activities initiated and conducted
through the CHN aim to improve quality of life by promoting physical activity and nutritional awareness.
In addition to the basic research of the principal
investigators, CHN also includes the following research
groups:
CHN’s Clinical Trials Division: conducts industry-
n
sponsored research with a focus on nutrition.
nostics. Trainees typically house their fundamental
Current areas of study include weight loss, weight
studies in the Mechanical Engineering Department at
maintenance, metabolic syndrome, and diabetes.
UC Boulder and participate in research projects that
This Division specializes in behavioral approaches to
involve the Departments of Integrative Physiology,
weight loss, delivered through group classes and/or
Pediatrics (Cardiology at The Children’s Hospital), and
one-on-one counseling, which can be tailored to suit
Cardiovascular Medicine at UCD. For doctoral students,
a particular protocol and combined with other treat-
the program supplies full stipend and tuition as well as
support for training-related expenses such as computers,
books, and travel to scientific conferences. For postdoctoral
ments.
Look AHEAD (Action for Health in Diabetes; funded
n
by NIH/NIDDK): a multicenter, randomized clinical
trainees, the program pays for stipend, supplies, and travel.
trial to examine the effects of a lifestyle intervention
Graduate training in translational bioengineering
designed to achieve and maintain weight loss over the
n
is provided to doctoral and master’s students. This
training is supported by several NIH T32 training
grants, especially in the areas of cardiovascular
long term through decreased caloric intake and exercise.
America On the Move Foundation: a national non-
n
profit organization, co-founded by Dr. James O. Hill,
bioengineering and pulmonary vascular disease.
Director of CHN, whose mission is to improve health
A formal graduate program in bioengineering, which
and quality of life by promoting healthful eating and
n
will grant doctoral and master’s degrees in bioengi-
active living among individuals, families, communi-
neering, will be implemented shortly.
Center for Bioengineering Faculty
Faculty
Robin Shandas, PhD•
Professor of Pediatrics
Director, Center for Bioengineering
Craig J. Lanning, BS•
Senior Professional Research Assistant
Kendall S. Hunter, PhD•
Assistant Professor of Pediatrics
ties, and society.
The Colorado Clinical Nutrition Research Unit
n
(CNRU; funded by NIH/NIDDK): has had an important impact on UCD since its inception in 1995 by
Wei Tan, PhD•
successfully fostering collaboration among members
Assistant Professor of Pediatrics
of its research base, promoting interdisciplinary
Timothy Scott, PhD•
Assistant Professor of Pediatrics
•
Cardiology Faculty
1 06 D e p a r t m e n t o f P e d i a t r i c s
research, and fostering development of young investigators. CNRU researchers continue to be successful in
programs
Her research interests also include measuring resting
energy expenditure, fat oxidation, total energy expenditure and activity levels in the National Weight Control
Registry’s long-term weight-reduced population. Dr
Wyatt also studies how diet composition affects longterm success in weight loss maintenance.
Education
The Center for Human Nutrition provides nutrition and
Center for Human Nutrition l - r: Ann Sauer, Tim Goss, Andra Price,
James Hill, Holly Wyatt
weight management education to UCD medical students,
interns, residents, fellows, and other health professionals
in the community and across the nation through several
attracting funding and in publishing research results.
programs. We provide a weekly lecture series at UCD; a
The CNRU maintains a research base which is com-
national, hands-on training program for physicians and
prised of over one hundred researchers who use
other health care professionals in the area of obesity,
one of our core laboratories (Energy Balance, Mass
through the Centers for Obesity Research and Education
Spectrometry, Metabolic) or who are working with a
(CORE); Obesity Management, a journal in its fourth
principal investigator who is doing so.
year, is aimed at bringing practical information about
obesity to health care providers in both the pediatric and
Research
adult populations; and America On the MoveВ® (AOM),
Dr. James Hill’s research in the obesity field involves
a program for the community to promote optimal nutri-
the study of lifestyle factors that affect body weight
tion, physical activity, and healthy weights.
regulation. In particular, he is interested in how diet and
physical activity influence body weight and how high-fat
Highlights
diet and inactivity may contribute to the current global
The Anschutz Foundation of Denver, Colorado, donated
epidemic of obesity. Dr. Paul MacLean’s work centers
$15 million toward the creation of a new Health and
on understanding the metabolic adaptations to weight
Wellness Center at the UCD Anschutz Medical Campus.
reduction that promote weight regain, with a particular emphasis on the utilization of ingested fuels in the
peripheral tissues. His lab employs obesity-prone rats to
model the process of weight regain that occurs in many
humans who are trying to lose weight. Dr. Edward
Melanson’s research interests are in the effects of diet,
exercise, and obesity on substrate metabolism and energy expenditure. Currently, Dr. Melanson is performing
studies on the effects of different intensities of exercise
and manipulations in dietary fat on fat oxidation.
Dr. Holly Wyatt’s research interests include studies
aimed at understanding whether energy metabolism is
altered in obese individuals and in individuals who are
successfully maintaining weight loss (reduced-obese).
Center for Human Nutrition Faculty
Faculty
James O. Hill, PhD+•
Professor of Pediatrics and Medicine
Director, Center for Human Nutrition
Nancy F. Krebs, MD++
Professor of Pediatrics
Section Head, Nutrition
Paul S. MacLean, PhD
Associate Professor of Medicine,
Physiology, and Biophysics
Edward L. Melanson, PhD
Associate Professor of Medicine
Holly R. Wyatt, MD
Associate Professor of Medicine
Fellows
Raymond Browning, PhD
(2006-2007)
Nanette Stroebele, PhD
(2004-2008)
Administrative Core
Gary K. Grunwald, PhD
Associate Professor of Pediatrics
Assistant Research Professor of
Biostatistics and Informatics,
Colorado School of Public Health
Director, Biostatistics and
Informatics Program
Lorraine Ogden, PhD
Assistant Professor of Biostatistics
and Informatics, Colorado School
of Public Health
2006-2008 Departmental Report
107
programs
Andra Price
Center Administrator and CNRU
Administrator
Ann Sauer
Grants and Contracts Specialist
Nutrition Faculty
Intellectual and Developmental
Disabilities Research Center Faculty
• Clinical Nutrition Research Unit
Faculty
+
+
Tim Goss
Center Coordinator
Children’s Outcomes
Research Program
Program Overview
The Children’s Outcomes Research (COR) Program
was initially authorized and funded by The Children’s
Hospital Research Institute (TCHRI) in 2001. Stephen
Children’s Outcomes Research Program Front row, l - r:
Jennifer Barrow, Sandra Black, Jennifer Pyrzanowski, Melissa Hobkirk;
Back row, l - r: Alison Saville, Kathryn Benton, Christine Babbel,
Patricia Shobe, Allison Kempe, Elizabeth Campagna, Matthew Daley,
Tara Janosz, Laura Seewald, Juliana Barnard
Berman, MD, was the first COR director, and Allison
Kempe, MD, MPH, has directed the Program since
Develop expertise in analysis of existing national
n
2007. The mission of the COR Program is to contrib-
databases and provide analytic support to investiga-
ute to an improvement of child health, both locally
tors collaborating with COR to use databases for
and nationally, by conducting state-of-the-art pediatric
publications or to provide pilot data for grant sub-
outcomes research that will impact clinical practice
missions.
and child health policy. The specific objectives of the
Provide “bridges” for consultation and collaboration
n
Program are to:
with researchers at COR and the Colorado Health
Develop focused areas of excellence in outcomes
Outcomes Program (COHO) at UCD in allied disci-
n
research of sufficient depth to result in national repu-
plines important to outcomes research.
tation for TCH and TCH faculty and major extramural funding in outcomes research.
Provide major research support to selected research-
n
COR provides support using four models
The Jump Start Model has been used in the past two
n
ers at TCH who make a significant commitment to
years to focus efforts on building new areas of out-
building outcomes research, including 1) methodolog-
comes research, primarily in surgical outcomes and
ical consultation, 2) assistance with data collection,
obesity prevention.
3) analytic support, 4) assistance with presentations
The Sustaining Model has provided less intensive sup-
n
and publications, and 5) assistance with grant writing.
port for areas of outcomes research that are already
Provide limited consultative support to researchers
successful in order to increase growth, primarily in
n
working outside of areas of focus for COR.
delivery of immunization and other preventive services
Develop and compile tools of general use to all
and evaluation of health care delivery for low-income
n
outcomes researchers at TCH including libraries of
measures and scales (e.g., quality of life, functional
children and children with special needs.
The Consultative Model has been used to provide
n
status, family and patient psychological well-being,
consultative services for numerous clinicians who
satisfaction with care).
wish to conduct clinical outcomes studies (in 18
Help in the development of clinical databases at TCH
different specialties).
n
and multi-institutional national outcomes databases
useful to TCH researchers.
1 08 D e p a r t m e n t o f P e d i a t r i c s
The Capacity Development Model has been used to
n
conduct educational seminars, to gather and develop
programs
analytic expertise in national databases, to develop
provide approximately 100 hours of outcomes research
libraries of data collection tools, and to create bridges
consultation each year to clinicians from approximately
among researchers in different areas.
18 specialties. Major areas of research focus for COR
are detailed below.
In addition to Dr. Kempe, COR’s core faculty and staff
includes Elaine Morrato, DrPH, an epidemiologist serv-
Preventive Care for Children
ing as senior methodologist; Lori Crane, PhD, MPH, a
Immunization Delivery
methodology expert on program evaluation and ques-
COR’s research initiatives focused on immunization
tionnaire design; Miriam Dickinson, PhD, a biostatisti-
delivery have been well-funded and have a track record
cian with expertise in health services research; Matthew
for influencing national vaccine policy. During 2006 to
Daley, MD, an experienced pediatric health services
2008, 44 abstracts were presented at national meetings,
researcher, particularly in immunization delivery, vac-
17 manuscripts were published, and 10 ongoing grants
cine safety, and preventive dental care; and Christina
were funded in this area. The CDC-funded Vaccine
Kim, MD, a pediatric health services researcher focused
Policy Collaborative Initiative, a national, rapid-response
on obesity prevention and immunization delivery. COR-
survey program of physicians regarding new vaccines,
related research involves seven professional research
new vaccine recommendations, and policy issues related
assistants and four analysts. Consistent with the NIH
to vaccination has been funded for the past four years
roadmap emphasizing interdisciplinary models of
and was refunded through 2010. Work from this grant
research, COR projects rely on multidisciplinary collab-
has routinely been presented at the Advisory Committee
orations among clinicians, epidemiologists, health ser-
for Immunization Practices. Two other CDC-funded
vices researchers, behavioral scientists, and statisticians
grants assessed vaccination reminder/recall systems for
at TCH, COHO, and UCD. In addition, COR collabo-
the adolescent patient in different practice sites and the
rates with The Children’s Hospital Outcomes Program
feasibility and acceptability of adolescent vaccination
directed by James K. Todd, MD; the Jules Amer
in non-traditional medical settings. Since 2007, COR
Community Pediatrics Program; the AAP; the Colorado
has been involved in the CDC-funded Vaccine Safety
Department of Public Health and Environment; Kaiser
Datalink, which rigorously investigates issues related
Permanente; Denver Health; a network of six private
to actual or potential adverse events following immu-
pediatric practices; and Bright Beginnings, a statewide,
nization. Dr. Simon Hambidge, supported by an RWJ
community-based nonprofit that serves more than
Faculty Scholar Award, completed several studies of
15,000 Colorado families.
strategies to improve immunization rates for disadvantaged children. Most recently, COR, in collaboration
Research
with Denver Health and the Denver Public Schools, was
Between 2006 to 2008, COR faculty and collaborators
awarded two grants to evaluate immunization delivery
presented 87 abstracts to national meetings and pub-
for the school-based adolescent and for influenza. We
lished 76 manuscripts in peer-reviewed journals. There
were the only recipient of the adolescent grant in the
were 31 funded grants and contracts received or ongo-
country and one of two for the influenza grant.
ing during 2006-2008. Grant funding increased steadily
during the three-year period, from $1.33 million to $2.3
Pediatric Preventive Oral Health
million. COR also provided consultation to investiga-
COR faculty have been involved in studies evaluat-
tors in many areas outside of our major focus areas
ing the value of incorporating hygienists into pediatri-
of research. Drs. Allison Kempe and Elaine Morrato
cian practices where disparities in oral health are high
2006-2008 Departmental Report
109
programs
with funding from The Delta Dental Foundation of
to first investigate the general epidemiology of selected
Colorado. Another study, conducted in collaboration
procedures by using national secondary datasets. This
with TCH Pediatric Dentistry and the Barbara Davis
has allowed us to generate pilot data to inform future
Center for Childhood Diabetes and funded by the
prospective research and to achieve early success in
Proctor and Gamble Company, is investigating the
meeting publication and scientific dissemination goals.
prevalence of periodontal disease in adolescents with
We have also begun the process of planning both ongo-
diabetes with the goal of testing preventive dental care
ing prospective data collection efforts and qualitative
interventions. COR faculty were also involved in the
research efforts in both areas. There are currently eight
newly NIH-funded Center for Native Oral Health
research projects underway focusing on outcomes of
Research (CNOHR), which will focus on reducing oral
spinal fusion musculoskeletal surgery and the High-
health disparities in vulnerable populations.
Risk Clinical Pathway for scoliosis surgery at TCH. In
addition, several new initiatives examining quality of
Prevention of Pediatric Obesity/CV Disease
life, exercise tolerance, and cardiopulmonary function-
This is an emerging priority area for COR and one
ing in children with pectus excavatum are underway. In
that is being pursued collaboratively with COHO. Drs.
General Pediatric Surgery, six projects are focusing on
Christina Kim, Allison Kempe, and Nancy Krebs have
variation in fundoplication surgical practices between
been involved in three obesity-prevention projects, one
different types of hospitals and regions of the country
involving a clinic-based educational intervention, one a
using the Pediatric Health Information System (PHIS)
community-based intervention, and the other assessing
and AHRQ Kids’ Inpatient Database (KID). COR has
reasons for lack of response to an obesity-prevention
also supported the development of the Pediatric National
intervention. Dr. Kim is part of a collaborative grant
Surgical Quality Improvement Program (NSQIP), through
proposal with COHO and Kaiser Permanente to estab-
its collaboration with COHO. NSQIP is the preeminent
lish population obesity registries in order to better under-
adult surgical outcomes improvement and research pro-
stand environmental factors contributing to this problem.
gram in the U.S., and COHO serves as the coordinating
Dr. Matthew Haemer, in collaboration with Dr. Krebs,
center for the Department of Veterans Affairs and the
has been studying implementation of a practice-based
American College of Surgeons public- and private-sector
educational intervention to identify and prevent obesity.
initiatives. Under the leadership of Dr. Moritz Ziegler,
Dr. Maya Bunik has been involved in a project also
TCH has also been selected as an alpha center for the
involving Dr. David Olds assessing the protective effect
Pediatric NSQIP program expansion, and COR will be
of breastfeeding on prevention of obesity in young chil-
assisting. The development of this database with TCH
dren. She is also collaborating with Dr. Margaret Neville
in the center of the development effort will provide sub-
(Department of Obstetrics and Gynecology, UCDSOM)
stantial opportunities for research for surgical faculty.
on a proposal to evaluate the effect of breastfeeding
problems on subsequent infant weight gain.
Health Care Delivery for Low-Income Children
COR has been assisting Dr. Steven Poole in evaluating
Surgical Outcomes Research
the Colorado Children’s Healthcare Access Program
The Musculoskeletal and General Pediatric Surgery
(CCHAP), a program aimed at increasing private pedia-
Departments have been actively collaborating with COR
trician’s involvement in providing care to low-income
to develop surgical outcomes research at TCH. Because
children. The Colorado Department of Health-Care
so little outcomes research has been done nationally in
Policy and Financing (HCPF) and 28 CCHAP-associated
these surgical areas, COR’s strategic approach has been
practices in the Denver area have partnered to conduct
1 10 D e p a r t m e n t o f P e d i a t r i c s
programs
a demonstration program from July 2007 through June
tion with the COR Program, and most of these faculty
2008 to evaluate a new program model designed to
are described unders their primary Section within the
increase provider participation in the Early and Periodic
Department of Pediatrics. Included here are only faculty
Screening Diagnosis and Treatment (EPSDT) program
who have their primary research home or office within
and provide a quality medical home for underserved
the COR Program.
children enrolled in Medicaid.
Dr. Stephen Berman conducts research on health
care delivery for underserved children and for children
Developing Areas of Focus
with special health care needs and otitis media; he is
Asthma Management
also involved with translation of research into policy
COR has consulted on a number of projects that focus
at the state and national levels. Dr. Maya Bunik is
on asthma care in pediatrics, including prevention and
involved in research about interventions to increase
chronic management in the primary care setting and
breastfeeding, the relationship between breastfeeding
emergency management. Drs. Maya Bunik and Monica
and obesity, asthma treatment, and pediatric telephone
Federico have been evaluating an educational and qual-
care. Dr. Matthew Daley’s research focuses on immu-
ity improvement intervention at the Child Health Clinic.
nization delivery, vaccine safety, and preventive dental
They are also participating in a federally-funded project
care. Dr. Steven Federico is engaged in research about
assessing the effect of different levels of cigarette smok-
health care delivery to low-income and minority popula-
ing on asthma outcomes. In addition, Dr. Marion Sills
tions and health literacy. Dr. David Fox is studying clin-
has focused on the emergency management of asthma
ical decision-making in the care of children with special
and has succeeded in obtaining three grants during the
health care needs and geographical variation in clini-
last year.
cal practices for these children. Dr. Simon Hambidge
is focused on immunization and other preventive care
Telephone and Internet Triage
delivery in underserved populations and vaccine safety.
Drs. Maya Bunik, Allison Kempe, and Barton Schmitt,
Dr. Allison Kempe is primarily involved in research
in collaboration with Kaiser Permanente, are studying
addressing immunization delivery, disparities in health-
a self-triage internet program that Dr. Schmitt has devel-
care, and pediatric telephone care. Dr. Christina Kim’s
oped in tandem with his telephone management protocols.
research is focused on obesity prevention and immunization delivery. Dr. Elaine Morrato is focusing on the
Drug Safety
adoption of drug safety recommendations into clinical
Dr. Elaine Morrato is focusing on the adoption of drug
practice and preventive dental care in diabetic patients.
safety recommendations into clinical practice. In 2007,
Dr. Marion Sills is studying delivery of emergent care
she had eight publications in this area and currently is
to children with asthma and quality improvement in the
leading research evaluating the adoption of diabetes
emergency room setting.
screening recommendations for patients taking secondgeneration antipsychotics. COR’s drug safety research
Education
will receive a big boost from a new AHRQ grant to
To raise general awareness and knowledge of research
COHO that has pediatric components.
methods, COR initiated an Outcomes Research
Methodology Series for faculty at TCH. The goal of this
Faculty Research Interests
lecture series is to provide an introduction to selected
Faculty members from many pediatric Sections and
important topics in outcomes research concepts through
Departments at TCH conduct research in collabora-
lectures and directed discussion of published research.
2006-2008 Departmental Report
111
programs
To date, the series has included the following topics: designing a good research question, assessing the
sensitivity and specificity of outcome measures, costeffectiveness measures, and applying the CONSORT
(Consolidated Standards of Reporting Trials) guidelines
when designing and publishing research.
For additional education outreach, COR has published with TCH surgical faculty monthly research
seminars in Methods and Applications in Outcomes
Research, sponsored by COHO. COR has also sponsored a training class on “Planning and Facilitating
Focus Groups” facilitated by researchers from
Denver Health.
For primary care clinicians, Dr. Kempe continues to
direct the Primary Care Research Fellowships, which
support mentored research training for 10 primary care
physicians per year, with two to three per year generally
coming from TCH. This fellowship program provides
didactic instruction in research methods, public health,
clinical teaching, and administrative skills, as well as
substantial protected time for research.
The Clinical Faculty Scholars Program, directed by
COHO, is designed to assist promising junior faculty
members to obtain career development awards or project support in outcomes research after their research
training. Dr. Kempe is involved in mentorship and the
grant writing curriculum. Since initiation in 2004,
there have been three Scholars with TCH affiliations:
Meica Efird, MD, MPH, Marion Sills, MD, MPH, and
Jeannie Zuk, RN, PhD.
Children’s Outcomes Research Program Faculty
Faculty
Allison Kempe, MD, MPH*
Professor of Pediatrics
Director, Children’s Outcomes
Research Program
Director, Primary Care Research
Fellowship
Stephen Berman, MD*
Professor of Pediatrics
Section Head of General
Academic Pediatrics
The Children’s Hospital Chair
in General Pediatrics
Patricia A. Braun, MD, MSPH**
Associate Professor of Pediatrics
Maya Bunik, MD, MSPH*
Associate Professor of Pediatrics
Medical Director, Child Health Clinic
Robert B. Clyman, MD+
Associate Professor of Pediatrics
and Psychiatry
Jack and Viki Thompson Chair in
Child Maltreatment and Family
Health
Executive Director, Kempe Center
for the Prevention and Treatment
of Child Abuse and Neglect
1 12 D e p a r t m e n t o f P e d i a t r i c s
Lori A. Crane, PhD
Associate Professor and Chair of
Community and Behavioral
Health, Colorado School of
Public Health
COR Behavioral Scientist
Matthew F. Daley, MD*
Associate Professor of Pediatrics
Arthur J. Davidson, MD, MSPH
Associate Professor of Family
Medicine
Paul V. Fennessey, PhD++++
Professor of Pediatrics and
Pharmacology
Vice Chair, Research
COR Senior Investigators
Coordinating Committee
Colorado Health Outcomes
Program Steering Committee
David Fox, MD*
Assistant Professor of Pediatrics
Judith E. Glazner, MS
Clinical Associate Professor of Health
Systems, Management, and
Policy, Colorado School of Public
Health
COR Economist
Simon J. Hambidge, MD, PhD***
Associate Professor of Pediatrics
David W. Kaplan, MD, MPH++
Professor of Pediatrics
Section Head, Adolescent Medicine
Chief Medical Information Officer
Christina A. Kim, MD, MSPH*
Instructor of Pediatrics
N. Elaine Lowery, JD, MSPH*
Clinical Instructor of Pediatrics
Program Manager, Colorado
Immunization Information System
Elaine H. Morrato, DrPh*
Assistant Professor of Pediatrics
Assistant Professor of Clinical
Pharmacy, School of Pharmacy
Assistant Professor of Health
Systems, Management, and Policy,
Colorado School of Public Health
Marion R. Sills, MD, MPH•
Assistant Professor of Pediatrics
Assistant Professor of Health
Systems, Management, and
Policy, Colorado School of
Public Health
John F. Steiner, MD, MPH
Professor of Internal Medicine
Director, Colorado Health
Outcomes Center
COR Senior Investigators
Coordinating Committee
James K. Todd, MD**++
Professor of Pediatrics and
Microbiology
Professor of Epidemiology,
Colorado School of Public Health
Section Head, Epidemiology
(Pediatrics)
Vice Chair, Advocacy (Pediatrics)
Jules Amer Chair in Community
Pediatrics
Director, Epidemiology, Clinical
Outcomes and Clinical
Microbiology, The Children’s
Hospital
Chair, Outcomes Committee
COR Senior Investigators
Coordinating Committee
Research Staff
Christine Babbel, MSPH
Professional Research Assistant
Jennifer C. Barrow, MSPH
Senior Professional Research
Assistant
Juliana G. Barnard, MA
Senior Professional Research
Assistant
Brenda Beaty, MSPH
Senior Professional Research
Assistant, Chief Analyst
Kathryn L. Benton, MSPH
Senior Professional Research
Assistant, Analyst
Sandra R. Black, DVM, CSPH
Professional Research Assistant,
Analyst
Elizabeth Campagna, MS
Senior Professional Research
Assistant, Analyst
Thea Carruth, MPH
Immunization Coordinator,
Colorado Immunization
Information System
Kathleen J. Haas, BSN, MPH
Professional Research Assistant,
Colorado Immunization
Information System
Kimberly B. Irby, MPH
Professional Research Assistant,
Colorado Immunization
Information System
Steve Jarvis
Developer, Colorado Immunization
Information System
Aleksey Kryuchkovskiy
Professional Research Assistant,
Colorado Immunization
Information System
programs
Kyle L. Osborn
Administrator
Renee S. Oxley
Senior Professional Research
Assistant
Kellyn A. Pearson, NR, MSN, CPNP
Immunization Coordinator, CIIS
Jennifer L. Pyrzanowski, MSPH
Professional Research Assistant
Alison W. Saville, MPH, MSW
Professional Research Assistant
Patricia R. Shobe, MPH
Professional Research Assistant
Linda Stremming
Professional Research Assistant, CIIS
* Infectious Diseases Faculty
* Epidemiology Faculty
* General Academic Pediatrics
Faculty
**Denver Health Faculty
**Children’s Outcomes Research
Program Faculty
Intellectual and Developmental
Disabilities Research Center Faculty
+
Nutrition Faculty
+
TCH Research Institute Faculty
+
Kempe Children’s Center Faculty
+
Clinical Genetics and Metabolism
Faculty
++
Community Pediatrics Faculty
++
Adolescent Medicine Faculty
• Emergency Medicine Faculty
+
Ellen Sullivan
COR Program Administrator
Clinical Trials Organization Front row, l - r: Sandi Lindahl,
Sharolene Goodman, Penny Hendrickson, Beth Esterl, Sheryl Faut;
Back row, l - r: Lita Gaskell, Julie Owens, Hazel Senz, Susan Brantz,
Kimberly Buda
Clinical Trials Organization
recording data. The CTO manages regulatory documents
Program Overview
during the course of the study, conducts sponsor moni-
The Clinical Trials Organization (CTO) was established
tor visits, and addresses queries from the sponsor. These
in 1997 to help promote the research component of
services are provided by an experienced and certified
The Children’s Hospital (TCH) mission. This “one-stop
research staff, with the goal of improving the efficiency
office” is available to all TCH investigators who desire
and quality of clinical research performance and enhanc-
assistance with clinical research projects. CTO staff,
ing the clinical research site at TCH.
which includes a medical director, clinical program
Since its inception, the CTO has served between
director, research coordinators and assistants, recruiter,
20-30 investigators annually, participated in 45-100
regulatory administrator, financial administrator, and
studies per year, and contributed significantly to the
financial assistant, helps with all aspects of clinical trials
increased clinical research activity occurring at TCH.
research. Early in the development of a study, tasks that
The majority of studies conducted by the CTO have
the CTO assists with include protocol review for deter-
been pharmaceutical industry-sponsored; however, a
mination of safety and feasibility, budget negotiation and
considerable number of studies have also been spon-
financial oversight, and preparation of regulatory docu-
sored by federal agencies, including the NIH and the
ments, including submission to the Institutional Review
CDC. In addition, some studies have been supported
Board and Investigational New Drug applications to the
by intramural funding, e.g., grants from the Research
FDA. Next, the CTO helps establish sites for recruitment
Institute at TCH. The CTO has assisted with stud-
of subjects into the study; coordinates study plans with
ies involving many different pediatric disciplines and
hospital services essential for many studies, including
encompassing a broad range of topics, including immu-
pharmacy, laboratory, radiology, and neuropsychology;
nizations; otitis media; tonsillectomy; reactive airways
and develops source documents specific to each study.
disease; cystic fibrosis; pediatric analgesia; viral, bacte-
Once a study has been set up and has received institu-
rial, and fungal infections; Kawasaki disease; acute and
tional approval, the CTO assists with subject recruit-
chronic liver disease; inflammatory bowel disease; pul-
ment and helps conduct study visits, including obtaining
monary hypertension; epilepsy; hemolytic-uremic syn-
and processing of laboratory specimens, performing
drome; inborn errors of metabolism; diabetes mellitus;
other required evaluations, dispensing medications, and
and autoimmune diseases. Studies have been conducted
2006-2008 Departmental Report
113
programs
in a variety of TCH venues, including the Child Health
Clinic, the Emergency Department, subspecialty clinics,
inpatient units, the Pediatric Intensive Care Unit, the
Newborn Center, and, since the fall of 2007, at the new
dedicated clinical research unit shared by the CTO and
the Clinical and Translational Research Center, which
offers infusion suites, a phlebotomy room, a specimen
processing area, clinical supplies storage areas, examination rooms, conference rooms, staff work areas, and
an intake room. Additionally, some studies have been
conducted in TCH satellite specialty clinics and in community pediatric practices.
Colorado Pediatric
Stroke Program
Clinical Services
The Colorado Pediatric Stroke Program (CPSP) at the
University of Colorado Denver and The Children’s
Hospital serves patients with arterial ischemic stroke,
hemorrhagic stroke, and cerebral sinovenous thrombosis. Formally established in 2007, the CPSP provides a
variety of services to pediatric stroke patients and their
families in a comprehensive multidisciplinary setting.
The goals of the CPSP are three-fold:
1.Establish and provide coordinated state-of-the-art
care for pediatric stroke in the Mountain States
Research
The CTO offers a full menu of services, including
assistance with study design; submissions for institutional approval (institutional review boards and clinical
research centers); budget development, contract negotiation and grants management; study site and patient
recruitment; and study nursing and study monitoring.
In addition, the CTO serves as a liaison between clinical
investigators and other institutional resources, e.g., biostatistics, laboratories, radiology, and pharmacy.
region of the U.S. from the time of the acute event
through long-term follow-up.
2.Educate affected patients, their families, and the
community about pediatric stroke.
3.Advance the fields of clinical, translational, and
outcomes research in pediatric stroke
The CPSP is codirected by Drs. Timothy Bernard and
Neil Goldenberg. Dr. Bernard, a pediatric neurologist, has been a member of the International Stroke
Study (IPSS) group for four years and has published
Faculty research interests are found in each investiga-
multiple articles on the treatment, risk factors, and out-
tor’s section/program.
comes for childhood arterial ischemic stroke. Another
Clinical Trials Organization Faculty
Faculty
Mark J. Abzug, MD*
Professor of Pediatrics
Medical Director, Clinical Trials
Organization
Clinical Staff
Elizabeth A. Esterl, RN, MS, CCRC
Director, Clinical Trials Organization
Susan L. Brantz, RN, BSN, CCRC
Certified Clinical Research
Coordinator
Kim Buda, RN, CRC
Clinical Research Coordinator
Sheryl H. Faut, RN, CRC
Clinical Research Coordinator
Lita P. Gaskell, BS, CCRC
Financial Administrator
Certified Clinical Research
Coordinator
Sharolene Goodman, RRT, CCRC
Certified Clinical Research
Coordinator
Penelope Hendrickson,
RN, BSN, CRC
Clinical Research Coordinator
pediatric neurologist, Dr. Jennifer Armstrong-Wells,
brings additional subspecialized expertise in hemorrhagic stroke and has recently published seminal work
in this area. Dr. Armstrong-Wells has recently been
named Director, Perinatal and Hemorrhage Stroke
Programs. Dr. Goldenberg, a pediatric hematologist, is
Sandra B. Lindahl, RN, MS, CCRC
Certified Clinical Research
Coordinator
an expert in childhood clotting disorders and has con-
Catherine McCool, MS, RD, CIM
Clinical Research Assistant
the pediatric thrombosis and stroke fields. As Director
Julie Owens
Clinical Research Assistant
Hazel Senz, RN, BSN, CCRC
Certified Clinical Research
Coordinator
* Infectious Diseases Faculty
1 14 D e p a r t m e n t o f P e d i a t r i c s
ducted and published numerous important studies in
of the Hemophilia and Thrombosis Center at UCD,
Dr. Marilyn Manco-Johnson provides world-renowned
coagulation expertise and clinical research leadership to
the CPSP.
programs
Dr. Jennifer Armstrong-Wells is investigating the
role of maternal inflammatory cytokines upon perinatal
stroke. She is also pursuing outcomes-oriented research
in childhood hemorrhagic stroke. Dr. Timothy Bernard
is researching inflammation, classification, treatments,
and outcomes in childhood arterial ischemic stroke.
He has recently been awarded the NIH, Colorado
Clinical and Translational Sciences Institute K12 grant,
entitled, “Markers of Inflammatory Coagulopathy and
Coagulation Activation as Predictors of Arteriopathy,
Recurrence and Outcome in Childhood Arterial Ischemic
Stroke.” Dr. Bernard is also a Colorado Health Outcomes
Colorado Pediatric Stroke Program Front row, l - r: Meghan Calhoon,
Neil Goldenberg, Timothy Bernard, Jennifer Armstrong-Wells,
Greta Wilkening; Middle row, l - r: Julie Bell, Laura Fenton,
Elizabeth Pounder, Wanda Wofford; Back row, l - r: Richard Boada,
C. Corbett Wilkinson, Jean Milholland, Jackie Roberts, Cassie Ross
Program Faculty Scholar. Dr. Neil Goldenberg has
ongoing research efforts in the role of lipoprotein(a)
in pediatric stroke, as well as novel assays of overall
coagulation and fibrinolytic function in these patients.
He also provides clinical trials expertise, with a PhD
Research
in clinical investigation. Dr. Goldenberg has K23 grant
The CPSP has multiple active efforts in clinical and
funding from the NIH.
translational research in pediatric stroke. Dr. Marilyn
Manco-Johnson provides world-renowned coagulation
Highlights
expertise and clinical research leadership to the CPSP
n
Timothy Bernard was selected for the Colorado
and direct mentorship to the stroke team. Local research
Health Outcomes (COHO) Program Clinical
efforts are ongoing in the areas of coagulation markers
Faculty Scholars Program (2008) and was granted
as predictors of outcomes in childhood stroke, lipo
an NIH, Clinical Translational Science Award
protein(a) as a risk factor for childhood arterial ischemic
Program K12 Career Development Award by the
stroke, and maternal and fetal risk factors in neonatal
Colorado Clinical Translational Science Institute
stroke, among others. Relationships between stroke
for his clinical and translational research in pediatric
risk factors, treatments, and outcomes are also stud-
arterial ischemic stroke.
ied through the Program’s prospective cohort study of
Neil Goldenberg received his PhD in Clinical
n
childrenwith stroke and thrombotic disorders. Since its
Investigation (2008) and was granted an NIH K23
inception, the CPSP has been a contributing member
Career Development Award by the NHLBI for his
of the IPSS, an international consortium of child neu-
clinical and translational research in pediatric
rologists and hematologists with expertise in pediatric
thrombosis.
stroke, which now includes over 30 participating centers
Jennifer Armstrong-Wells was recruited from the
n
and is led by Dr. Gabrielle deVeber of the Hospital for
University of California San Francisco to join the
Sick Children in Toronto, Canada. The Program also
Colorado Pediatric Stroke Program as a second pedi-
has active research collaborations with pediatric stroke
atric stroke neurologist and has recently been named
leaders at other institutions, including Dr. Rebecca Ichord
Director, Perinatal and Hemorrhage Stroke Programs.
at the Children’s Hospital of Philadelphia and Dr. Ulrike
Nowak-Göttl at the University of Münster, Germany.
2006-2008 Departmental Report
115
programs
Colorado Pediatric Stroke Program Faculty
Faculty
Timothy J. Bernard, MD••
Assistant Professor of Pediatrics
Co-Director, Colorado Pediatric
Stroke Program
Neil A. Goldenberg, MD, PhD••
Assistant Professor of Pediatrics
and Medicine
Co-Director, Colorado Pediatric
Stroke Program
Associate Director, UCD Hemophilia
and Thrombosis Center
Jennifer Armstrong-Wells,
MD, MPH••
Assistant Professor of Pediatrics
Director, Perinatal and Hemorrhage
Stroke Programs
Richard Boada, PhD••
Assistant Professor of Pediatrics
Clinical Neuropsychologist
Jean Milholland, MS, PA-C••
Instructor of Pediatrics
Elizabeth Pounder, MS, PA-C
Senior Instructor of Pediatrics
Marilyn Manco-Johnson, MD••
Professor of Pediatrics
Director, UCD Hemophilia and
Thrombosis Center
Greta N. Wilkening, PsyD••
Associate Professor of Pediatrics
Director, Neuropsychology
•• Child Neurology Faculty
•• Hematology, Oncology and
BMT Faculty
Colorado WIN Partners Front row, l - r: Yvonne Kellar-Guenther,
William Betts, Laura Valdez, Nancy Koester, Anna Ropp; Back row, l - r:
Judith Emery, Patrick Loeber, Peter Pike, Robyn Mobbs, Edie Bridge
training and technical assistance activities nationally and
statewide focused on systems collaboration/partnerships
Colorado WIN Partners
and strategies to effectively encourage people with disabilities to move toward independence. These activities
Program Overview
include face-to-face training, use of live Webinars, and
The focus of Colorado WIN Partners is to assist indi-
electronic sessions available 24 hours a day, 7 days a
viduals with disabilities to maximize independence
week. Additionally, Colorado WIN Partners has state
through employment, health management, and com-
and local contracts to conduct evaluation from design
munity-based opportunities. Colorado WIN Partners
through implementation, to analysis and report writing.
offers services in the following areas: training and technical assistance, research and evaluation, and project
Research
management and facilitation. Colorado WIN Partners
Colorado WIN Partners conducts applied, community-
achieves this through collaboration with federal part-
based research with an emphasis on evaluating services
ners such as Social Security Administration (SSA) and
for persons with disabilities aimed at maximizing inde-
U.S. Department of Labor and Employment (USDOL),
pendence through employment, health management,
state partnerships with Colorado Department of
and community-based opportunities. Our research is
Human Services, Colorado Department of Labor and
designed to help service providers identify and utilize
Employment and the State Workforce Development
innovative and cutting-edge evidence-based practices.
Council, and private businesses. Colorado WIN
Federal and state agencies, research firms, communi-
Partners is part of SSA’s national Youth Transition
ty-based non-profits, and other organizations contract
Demonstration that is generating empirical evidence
with us to provide evaluation of new and innovative
in four Colorado sites on impacts of SSI waivers and
programs. For example, we have had contracts and/or
service delivery systems for youth ages 14-25 transition-
grants with Colorado Department of Human Services,
ing to post-secondary education and economic self-
The Lewin Group, Social Security Administration,
sufficiency. In addition, Colorado WIN Partners devel-
Mathematica Policy Research, Inc., U.S. Department of
ops training and technical assistance tools for use with
Labor, Colorado Department of Labor and Employment,
Colorado and USDOL’s national Disability Program
Colorado Workforce Development Council, Health
Navigator Initiative. Colorado WIN Partners delivers
Resources and Services Administration/Colorado
1 16 D e p a r t m e n t o f P e d i a t r i c s
programs
Department of Public Health and Environment, Easter
Colorado WIN Partners explores cross-cultural concep-
Seals Colorado, Jefferson County Workforce, Colorado
tions of disability and ability.
Division of Vocational Rehabilitation/HHS, Colorado
Workforce Development Council, Denver Health,
Education
Colorado Health Foundation, Virginia Commonwealth
Colorado WIN Partners was contracted by the Colorado
University, and University of Iowa.
Workforce Development Council (CWDC) to create
Approximately 31% of our funding comes from fed-
a seven-module Online Disability Awareness Training
eral grants and contracts, 31% from state grants and
for the staff of the Colorado Workforce Investment
contracts, and 38% from private sources. Some of our
System. These modules have been delivered through
current projects include: (1) a randomized control study
the Colorado Department of Labor and Employment’s
looking at youth who receive Social Security disability
electronic portal. The CWDC included the online dis-
benefits and services that can help them gain and main-
abilities awareness course as one of the elements of the
tain employment; (2) design of a data collection tool to
2007-2008 Continuous Improvement Incentive Awards
assess the development and technical assistance needs
available to each workforce region. This is going to be
of Disability Program Navigators across the country;
repeated for 2008-2009 and three additional training
(3) evaluation of a program designed to provide youth
modules will be added to this coursework. Colorado
with disabilities a way of collecting the information and
WIN Partners has been recognized by other Workforce
documents needed to gain employment; and (4) evalu-
Professional Associations for this online training and has
ation of training efficacy including training for health
received the Specialized Services Award by the Colorado
care providers using simulations.
Chapter of the International Association of Workforce
Dr. William Betts’ interests include community mental
Professionals for this online training effort.
health, community-based collaboration, children in foster care, and program evaluation. Judith Emery, MA,
Highlights
has research interests in assisting underrepresented
Colorado WIN Partners has received the Specialized
populations, youth in transition, and individuals with
Services Award by the Colorado Chapter of the
disabilities in maximizing their independence in the areas
International Association of Workforce Professionals for
of community-integrated employment and community-
creating a seven-module Online Disability Awareness
based opportunities and participation. Dr. Yvonne
Training Program.
Kellar-Guenther’s research interests are in forming collaborative relationships, medical home, patient navigation
education, health literacy, involvement of persons with
disabilities in research studies, and program evaluation.
Nancy Koester, MSW, has research interests that include
evaluation of systems change efforts, development of
collaborative relationships, employment incentives for
people who are under-employed and improving health
care information for those who need it. Dr. Anna Ropp’s
dissertation investigated gender discrimination, particularly women’s responses to discrimination, and she
has continued this work by researching discrimination
against the LGBT population. Currently, her research at
Colorado WIN Partners Faculty
Faculty
Judith L. Emery, MA
Senior Instructor of Pediatrics
Director, Colorado WIN Partners
Robyn Mobbs, MBA
Instructor of Pediatrics
Finance Manager
William R. Betts, PhD
Senior Instructor of Pediatrics
Evaluator
Peter J. Pike, BA
Instructor of Pediatrics
Associate Director, Colorado WIN
Partners
Yvonne Kellar-Guenther, PhD
Associate Professor of Psychiatry, UCD
Lead Evaluator
Anna Ropp, PhD
Instructor of Pediatrics
Evaluator
Nancy Koester, MSW
Research Instructor of Pediatrics
Evaluator
Laura Valdez, BS
Grants and Contracts Manager
Patrick E. Loeber, BS
Professional Research Assistant
Disability Program Navigator
Coordinator
Edie Bridge, AS
Professional Research Assistant
2006-2008 Departmental Report
117
programs
Gastrointestinal
Eosinophil Center
Clinical Services
The Gastrointestinal Eosinophilic Diseases Program
(GEDP) at The Children’s Hospital and National Jewish
Health provides state-of-the-art, multidisciplinary care
to patients affected by eosinophilic gastrointestinal diseases (EGIDs), including eosinophilic esophagitis (EE).
This team of medical professionals from two world-class
healthcare institutions is the only multidisciplinary program caring for children with EGIDs in the midwestern
United States and Rocky Mountain Region.
EGIDs are a group of diseases characterized by
a wide variety of gastrointestinal symptoms including vomiting, swallowing problems, food impaction,
abdominal pain, diarrhea, slow growth, and bleeding.
These symptoms occur in combination with increased
Gastrointestinal Eosinophil Center Front row, l - r: Stephanie Petersburg,
Joanne Newton, Samantha Woodruff, Wendy Moore, Kathy Spomer;
Middle row, l - r: Felicia Timoteo, Nancy Creskoff-Maune, Michelle
Henry, Meridith Berger, Mary Klinnert; Back row, l - r: Angela Haas,
Glenn Furuta, F. Dan Atkins, Michael Miller, David Fleischer
numbers of eosinophils in the gastrointestinal lining.
allergic diseases and has a research focus on food aller-
Eosinophils are a type of white blood cell that has been
gic diseases. Three dieticians, Catherine Santagelo, RD,
primarily associated with allergic diseases but are also
Kristin Brown, RD, and Emily McCloud, RD, provide
found in other diseases.
outstanding nutritional expertise. Angela Haas, MA,
Depending on the part of the GI tract affected, EGIDs
SSS-SLP, and Nancy Maune, OTR, are experienced
can be called a variety of different names, such as
members of the Feeding Program at The Children’s
eosinophilic esophagitis (EE), eosinophilic gastritis (EG),
Hosptial who provide diagnostic and therapeutic
eosinophilic gastroenteritis (EGE), and eosinophilic coli-
expertise when necessary.
tis (EC), with the diagnostic term being based primarily
on the location of the mucosal eosinophilia.
Patients and families are provided with the latest in
Research
The Gastrointestinal Eosinophil Research Program
clinical services ranging from endoscopic assessment,
(GERP) performs novel research focusing on eosino-
allergy testing, and in some circumstances, novel treat-
phils’ impact on the gastrointestinal tract. Studies center
ment protocols. Importantly, a wide range of clinical
on the mechanisms that eosinophils relate to resident
research projects are being conducted to uncover new
cells of the intestinal tract and how these relationships
knowledge and improve patient care. Interested patients
contribute to host health and disease.
are offered the opportunity to participate in any protocol.
The GERP consists of two investigators and two
Dr. Glenn Furuta, Director of the Program, is a pedi-
postdoctoral fellows. Dr. Glenn Furuta is a physician-
atric gastroenterologist whose work focuses on identify-
scientist whose work examines the role of eosinophil’s
ing clinical features of EGIDs and developing methods
GI function. Dr. Sophie Fillon is an Instructor of
for patient assessment and treatment. Dr. F. Dan Atkins,
Pediatrics with an expertise on innate defense mecha-
Co-Director of the Program, brings both clinical exper-
nisms. Drs. Vince Mukkada and Samantha Woodruff
tise and research experience in food allergy to the team.
are pediatric gastroenterology fellows at The Children’s
Dr. David Fleischer is an experienced clinician in food
Hospital whose focus is on understanding the relation-
1 18 D e p a r t m e n t o f P e d i a t r i c s
programs
ships between the eosinophil and the intestinal epithelium. Zachary Robinson, MS, is the laboratory coordinator who supervises the laboratory and participates in
research projects. Joanna Grenawalt is a professional
research assistant. Wendy Moore, MPH, is the translational research coordinator who manages the clinical
research protocols and handles recruitment of study
subjects. The laboratory is currently located in the
Clinical Staff
Kristin Brown, MS, RD
Program Nutritionist
Angela Haas, MA, CCC-SLP
Feeding Disorders Program Specialist
Nancy Creskoff Maune, OTR
Occupational Specialist
Emily McCloud, MS, RD
Program Nutritionist
Catherine Santangelo, RD
Program Nutritionist
Kathy Spomer, RN, BSN
Program Co-Coordinator
Administrative Staff
Felicia Timoteo
Administrator
**National Jewish Health Faculty
•• Gastroenterology, Hepatology
and Nutrition Faculty
Research Complex II at the Anschutz Medical Campus
in Aurora, Colorado.
Program (MIP) in the Gastroenterology Division at the
Intellectual and Developmental
Disabilities Research Center
UCD School of Medicine that is directed by Dr. Sean P.
Program Overview
Colgan. The MIP carries an overall theme of determin-
The Colorado Intellectual and Developmental
ing mechanisms of inflammation at a variety of mucosal
Disabilities Research Center (IDDRC) was established
surfaces including the GI tract and the lung. Taken
in 1968 and is one of only 13 such centers funded by
together, the Gastrointestinal Eosinophil Center and
the Eunice Kennedy Shriver National Institute of Child
Mucosal Inflammation Program unite a unique blend of
Health and Human Development. The current IDDRC
basic and clinical investigators. This integration of basic
director is Karl H. Pfenninger, MD.
The GERP is a part of the Mucosal Inflammation
and clinical sciences and multidisciplinary approach fos-
The IDDRC is a multidisciplinary and collaborative
ters collaboration between key personnel from different
program that facilitates research on the pathogenesis,
divisions of UCD to provide outstanding patient care
diagnosis, treatment, and prevention of neurodevelop-
and novel research outcomes.
mental disorders; the amelioration of secondary condi-
Gastrointestinal Eosinophil Center Faculty
Faculty
Glenn T. Furuta, MD••
Associate Professor of Pediatrics
Director, Gastrointestinal Eosinophil
Center
Wendy Moore, MPH
Professional Research Assistant
Translational Research Coordinator,
Gastrointestinal Eosinophilic
Diseases Program
F. Dan Atkins, MD**
Associate Professor of Pediatrics
Co-Director, Gastrointestinal
Eosinophilic Diseases Program
Director, Ambulatory Pediatrics and
Medical Director of the Pediatric
Day Program, National Jewish
Health
Stephanie Petersburg, PA••
Senior Instructor of Pediatrics
Program Coordinator,
Gastrointestinal Eosinophilic
Diseases Program
Sophie Fillon, PhD••
Senior Instructor of Pediatrics
David M. Fleischer, MD**
Assistant Professor of Pediatrics
Pediatric Allergist
Joanna Grenawalt
Professional Research Assistant
Gastrointestinal Eosinophil Research
Program
Zachary Robinson, MS
Professional Research Assistant
Laboratory Manager,
Gastrointestinal Eosinophil
Research Program
Fellows
Vince Mukkada, MD (2005–2008)
Samantha Woodruff, MD
(2006-2009)
tions; and the integration of individuals with intellectual
and developmental disabilities into their communities.
The IDDRC’s research is based upon the premise that
successful treatments can be devised only if the genetic,
molecular, cellular, and behavioral parameters of a condition are known and if the mechanism of pathogenesis
of the disease is understood.
Investigators of the IDDRC come from the
Department of Pediatrics and from several other
departments within the School of Medicine, including Pharmacology, Cell and Developmental Biology,
Cardiology, Neurology, Psychiatry, and Medicine. The
IDDRC provides support for fundamental, translational
and clinical research to its investigators through core
facilities. The core facilities provide investigators access
to and expertise in complex technologies. The research
cores are: (1) Translational Nexus, a patient registry,
database and biobank focused on neurodevelopmental
2006-2008 Departmental Report
119
programs
disorders; (2) Animal Models, providing assistance with
animal husbandry, behavioral assessment, brain imaging, and for the generation of mutant mouse models
of disease; (3) Cell Systems and Analysis, for research
at the cellular and tissue levels; and (4) Molecular
Discovery, providing assistance and technologies for
genomic, transcriptomic and proteomic studies, for vector construction, and for molecular structure analysis.
Highlights of the Center’s activities over the years
have included:
delineation of several previously unknown disorders
n
associated with intellectual and developmental
disabilities;
characterization of cognitive phenotypes of Fragile X
n
syndrome, Down syndrome, PKU and autism;
development of neonatal screening for early detection
n
of genetic disorders affecting nervous system development and function; and
Intellectual and Developmental Disabilities Research Center
Front row, l - r: Nicole Tartaglia, Michael Woontner, Elaine Spector,
Mark Dell’Acqua; Second row, l - r: Ann Reynolds, Stephen Goodman,
Richard Spritz, Kimberly Bjudstad, Katheleen Gardiner; Third row,
l - r: Johan Van Hove, Frank Frerman, Alberto Costa, Karl Pfenninger,
Jan Kraus; Back row, l - r: James Sikela, Kenneth Maclean,
Nicholas Seeds
Education
establishment and characterization of mouse models
The IDDRC trains graduate students and postdoctoral
of human disorders, such as Down syndrome and
associates in IDD research. Graduate and postdoctoral
Fragile X syndrome, to study neurodevelopmental
training opportunities are available through the Human
disease mechanisms and treatments.
Medical Genetics Training Program, the Neuroscience
n
Program, the Developmental Psychobiology Training
Research
Program, the Leadership Education in Neurodevelop-
The IDDRC is a comprehensive research unit dedicated to
mental Disabilities (LEND) Program at UCD, and
the advancement of diagnosis, epidemiology, prevention,
individual investigators.
treatment and amelioration of intellectual and developmental disabilities (IDD). Research areas of particular
strength are inborn errors of metabolism causing IDD,
neurodevelopmental biology, development of child behavior and cognition, Down syndrome, autism spectrum disorders, and assistive device technology. Center members
are investigating IDD with a broad range of approaches,
from molecular genetics and reductionist neuroscience to
behavior assessment (human, animal) and clinical trials.
Faculty’s research interests are listed in each
investigator’s section/program.
IDDRC Faculty
Faculty
Karl H. Pfenninger, MD+
Professor of Pediatrics and Cell
and Developmental Biology
Director, Intellectual and
Developmental Disabilities
Research Center
Bruce Appel, PhD••
Associate Professor of Pediatrics
Kristin Artinger, PhD
Assistant Professor of Craniofacial
Biology, School of Dentistry
Timothy Benke, MD, PhD••
Associate Professor of Pediatrics,
Neurology and Pharmacology
Kimberly Bjugstad, PhD+
Assistant Professor of Pediatrics
1 20 D e p a r t m e n t o f P e d i a t r i c s
Cathy Bodine, PhD, CCC-SLP
Associate Professor of Physical
Medicine and Rehabilitation
and Pediatrics
Amy Brooks-Kayal, MD••
Professor of Pediatrics
Section Head, Child Neurology
Laura D. Brown, MD*•
Assistant Professor of Pediatrics
Alberto Costa, MD, PhD
Associate Professor of Medicine,
Division of Clinical Pharmacology
and Toxicology
Mary E. Coussons-Read, PhD
Associate Professor of Psychology
Mark Dell’Aqua, PhD
Associate Professor of Pharmacology
programs
Ellen R. Elias, MD+*
Associate Professor of Pediatrics
Kenneth N. Maclean, PhD+
Assistant Professor of Pediatrics
Paul V. Fennessey, PhD++**+
Professor of Pediatrics and
Pharmacology
Vice Chair, Research
David K. Manchester, MD+
Professor of Pediatrics and
Pharmacology
Lee Niswander, PhD••
Professor of Pediatrics
Section Head, Developmental
Biology
Robert Freedman, MD
Professor of Psychiatry
and Pharmacology
Frank E. Frerman, PhD+
Professor of Pediatrics and Cell
and Developmental Biology
Professor of Pharmaceutical
Sciences, School of Pharmacy
Jacob E. Friedman, PhD*•
Professor of Pediatrics, Biochemistry
and Molecular Genetics
+
Renata C. Gallagher, MD, PhD
Assistant Professor of Pediatrics
Katheleen Gardiner, PhD+
Research Professor of Pediatrics
+
Stephen I. Goodman, MD
Professor of Pediatrics
David Patterson, PhD
Professor of Biological Sciences,
University of Denver
Clinical Professor of Psychiatry, UCD
Judith Reaven, PhD++
Assistant Professor of Psychiatry
and Pediatrics
Diego Restrepo, PhD
Professor of Cell and Developmental
Biology
Director, Neuroscience Program
Ann M. Reynolds, MD•++
Assistant Professor of Pediatrics
Director, Child Development Unit
Richard A. Spritz, MD+
Professor of Pediatrics and
Biochemistry and Molecular
Genetics
Professor of Cranofacial Biology,
School of Dentistry
Director, Human Medical Genetics
Program
Developmental Biology Faculty
Boris Tabakoff, PhD
Professor and Chair of
Pharmacology
Nicole R. Tartaglia, MD•
Assistant Professor of Pediatrics
Matthew Taylor, MD, PhD
Associate Professor of Medicine
Janet A. Thomas, MD+
Associate Professor of Pediatrics
Clinical Director, Clinical Genetics
Director, Inherited Metabolic
Diseases Clinic
Chun-Hui (Anne) Tsai, MD, MSc+
Associate Professor of Pediatrics
Johan Van Hove, MD, PhD+
Associate Professor of Pediatrics
Section Head, Clinical Genetics
and Metabolism
Deborah A. Hall, MD
Assistant Professor of Neurology
Cordelia Robinson, PhD, RN++
Professor of Pediatrics and Associate
Professor of Psychiatry and
Nursing
Director, JFK Partners
K. Michael Hambidge, MD, ScD+
Professor Emeritus of Pediatrics
Donald C. Rojas, PhD
Associate Professor of Psychiatry
JFK Partners
William W. Hay, Jr., MD*
Professor of Pediatrics
Randal G. Ross, MD
Professor of Psychiatry and
Pediatrics
Clinical Services
James Grigsby, PhD
Professor of Medicine
Susan Hepburn, PhD++
Assistant Professor of Psychiatry
and Pediatrics
+
Paul Rozance, MD*
Assistant Professor of Pediatrics
+
Greta Wilkening, PsyD••
Associate Professor of Pediatrics
Michael Woontner, PhD+
Assistant Professor of Pediatrics
Audrey Yee, MD••
Assistant Professor of Pediatrics
* Pulmonology Faculty
* Neonatology Faculty
* General Academic Pediatrics
Faculty
**Children’s Outcomes Research
Program Faculty
Nutrition Faculty
+
TCH Research Institute Faculty
+
Clinical Genetics and Metabolism
Faculty
++
JFK Partners Faculty
++
TCH Clinical Translational
Research Center Faculty
• Developmental and Behavioral
Pediatrics Faculty
• Perinatal Research Center Faculty
•• Developmental Biology Faculty
•• Child Neurology Faculty
+
JFK Partners has provided interdisciplinary clinical and
community-based services and support to individuals
with developmental disabilities and their families in
Susan Johnson, PhD
Associate Professor of Pediatrics
Gunter Scharer, MD, PhD
Assistant Professor of Pediatrics
Colorado and the Rocky Mountain Region for more
Jan P. Kraus, PhD+
Professor of Pediatrics and Cell
and Developmental Biology
Nicholas W. Seeds, PhD
Professor of Biochemistry and
Molecular Genetics
Hospital were named one of fifteen sites in the nation
Nancy F. Krebs, MD+
Professor of Pediatrics and
Preventive Medicine and
Biometrics
Section Head, Nutrition
Geeta Sharma, PhD
Instructor of Physiology and
Biophysics
aims to develop common clinical standards for medi-
James M. Sikela, PhD
Professor of Pharmacology
(ASD) and to increase the pool of autism medical spe-
Leslie A. Krushel, PhD
Assistant Professor of Biochemistry
and Molecular Genetics
John R. Sladek Jr., PhD+
Professor of Pediatrics
Vice Chancellor for Research, UCD
Maureen Anne Leehey, MD
Professor of Neurology
Elaine B. Spector, PhD+
Associate Professor of Pediatrics
Director, UCD DNA Diagnostic
Laboratory
Sherry S. Leonard, PhD
Associate Professor of Psychiatry
and Pharmacology
than 40 years. In 2008, JFK Partners and The Children’s
for the Autism Treatment Network (ATN). The ATN
cal care for individuals with autism spectrum disorder
cialists through trainee mentorship and outreach to
community-based physicians. In September 2008, JFK
Partners was also awarded a three-year Leadership
Education in Neurodevelopmental and Related
Disabilities (LEND) Training Grant to provide longterm, graduate-level interdisciplinary leadership training
as well as interdisciplinary services and care. The JFK
Partners clinical and community-based services include:
2006-2008 Departmental Report
121
programs
JFK Partners Front row, l - r: Cordelia Robinson, Lisa Swenson, Tracy Price-Johnson, Janet Campbell, Marguerite Monson, Dalice Hertzberg, Teresa
RenГ©e Charlifue-Smith; Middle row, l - r: Sarah Hoover, Annie Immele, Alyson Hatten, Siobhan Sullivan, Teresa Hall, Kathleen Culhane-Shelbourne,
Judy Reaven; Back row, l - r: Debra Schell-Frank, Michael Maza, Sandra Link, David Conrad, Catherine Hovey, Audrey Blakeley-Smith, Dylan Carelli
The Autism and Developmental Disabilities Clinic:
Research
Providers in this clinic offer disciplinary and interdisci-
JFK Partners has developed an international reputation
plinary evaluations, differential and follow-up diagnostic
for research in autism and other developmental disabili-
services, and individual and group treatment for individ-
ties. Research is focused on four themes: intervention
uals with developmental disabilities and their families.
science, epidemiological research, neurobiological stud-
Annually, approximately 400 evaluations are completed.
ies, and program evaluation. Due to the complexities of
neurodevelopmental disorders and the need for a multi-
ENRICH (Enrichment Using Resources in the
disciplinary perspective on research issues, collaborative
Community and Home): Using a transdisciplinary
science is emphasized and fostered at JFK Partners.
approach, JFK Partners faculty deliver early intervention
n
JFK Partners is currently engaged in national
(Part C Early Intervention Colorado) services through
network studies through the Centers for Autism
home and child care visits. Approximately 80 Part
and Developmental Disabilities Research and
C-eligible children and families are served annually in
Epidemiology (CADDRE) and the Autism and
this program.
Developmental Disabilities Monitoring Network
(ADDM) [funded by the CDC], and the Autism
FASL (Family Driving Autism Services and Learning):
Treatment Network (ATN) [funded by Autism Speaks
A program developed in response to Colorado’s Autism
and HRSA]. JFK Partners was also a site for the
Waiver, FASL is a community-based intervention pro-
National Institute of Child Health and Development’s
gram for children with autism under the age of six.
Collaborative Programs of Excellence in Autism for
Since its inception in 2007, FASL has provided services
the entire 10-year funding period and continues to
for more than 40 children and families.
share and refer patients to genetics and neurobiological
studies supported by the NIH and other foundations.
1 22 D e p a r t m e n t o f P e d i a t r i c s
programs
JFK Partners faculty are currently engaged in 22
n
programs based upon developmental theory and
approved research protocols with co-investigators in
empirical literature for young children with dis-
various fields, including clinical psychology, special
abilities, assessment and modification of parental
education, pediatrics, public health, psychiatry, social
teaching styles, and evaluation of intervention pro-
neuroscience, family studies, genetics, neurology,
grams for young children with disabilities. Dr. Steven
sleep medicine, and gastroenterology.
Rosenberg has a research focus on children with dis-
JFK Partners also provides mentored research training
abilities and their families. Over the last 12 years
to new investigators or experienced researchers seek-
Dr. Rosenberg has developed a program to train
ing opportunities to study developmental disabilities.
school staff in procedures that increase learners’
n
Dr. Audrey Blakeley-Smith, in collaboration with
access to activities in inclusive settings and has
the Littleton Public Schools, is currently working on
studied access of maltreated infants and toddlers
a study to provide trainings to elementary school
to Part C early intervention.
children on strategies to interact with their classmates
who have autism spectrum disorders (ASD). She is
Education
assessing the effectiveness of cognitive and behav-
JFK Partners provides a variety of unique training
ioral strategies to support typically developing peers
opportunities for physicians, psychologists, speech-
in facilitating social skill development in students
language pathologists, physical therapists, occupational
with ASD. Additionally, she is collaborating with
therapists, and other related services professionals seek-
Drs. Judy Reaven and Susan Hepburn in a study
ing specialized training in working with individuals with
that examines the effectiveness of cognitive behavior
developmental disabilities, including autism, and their
group therapy in the reduction of symptoms of anxi-
families. Further information about JFK Partners train-
ety in children and adolescents with ASD. Dr. Susan
ing opportunities is located on the JFK Partners Web
Hepburn’s research focuses on children with autism
site (www.jfkpartners.org).
and those with other neurodevelopmental disorders,
exploring the specificity of the autism phenotype,
Highlights
examining patterns of comorbidity across conditions,
In 2008, JFK Partners and The Children’s Hospital were
and investigating effective psychosocial interven-
named one of fifteen sites nationally for the Autism
tions aimed towards treatment of core and associated
Treatment Network. This Network aims to develop
symptoms of ASD. Dalice Hertzberg, RN, MSN, has
common clinical standards for medical care for individu-
research interests in health transition for youth with
als with autism spectrum disorders and to increase the
disabilities and health promotion for people with dis-
pool of autism medical specialists through trainee men-
abilities. Dr. Hal Lewis has research interests in ASD,
torship and outreach to community-based physicians.
pediatric traumatic brain injury, ADHD, and applied
research in developmental psychopathology and
developmental disabilities. Dr. Judy Reaven’s research
interests are in the co-occurrence of mental health
symptoms in children with ASD. Particular interests
include the development of treatment protocols for
children and adolescents with high-functioning ASD
and anxiety symptoms. Dr. Cordelia Robinson has
research interests in the development of intervention
JFK Partners Faculty
Faculty
Cordelia Robinson, PhD, RN+
Professor of Pediatrics, Psychiatry,
Rehabilitation Medicine, and
Adjoint Professor of Nursing
Director, JFK Partners
Audrey Blakeley-Smith, PhD
Assistant Professor of Psychiatry
and Pediatrics
Harriet Austin, PhD•
Instructor of Pediatrics
Coordinator, Autism Treatment
Network
Bonnie Camp, MD, PhD
Professor Emerita of Pediatrics
Joy V. Browne, PhD, RN
Associate Professor of Pediatrics
Teresa RenГ©e Charlifue-Smith, MA,
CCC-SLP
Senior Instructor of Pediatrics
2006-2008 Departmental Report
123
programs
David J. Conrad, LMSW - ACP
Senior Instructor of Pediatrics
Siobhan Sullivan, MS, PT
Instructor of Pediatrics
Kathleen A. Culhane-Shelburne, PhD
Clinical Instructor of Pediatrics
Dina Johnson, BS
Training and Data Coordinator
Judy Dettmer, BA
Instructor of Pediatrics
Lisa Swenson, BS, PT
Senior Instructor of Pediatrics
Heidi Eigsti, DPT
Clinical Instructor of Pediatrics
Jeannie Losh
ENRICH Coordinator and Assistant
to the Director
Larry Edelman, MS
Senior Instructor of Pediatrics
Mary Gonnella, MSW
Senior Instructor of Pediatrics
Teresa L. S. Hall, MA, CCC-SLP
Senior Instructor of Pediatrics
Alyson L. Hatten, MS
Senior Instructor of Pediatrics
Susan Hepburn, PhD
Assistant Professor of Psychiatry
and Pediatrics
Dalice Hertzberg, RN, MSN
Senior Instructor of Pediatrics
and Nursing
Sarah L. Hoover, MEd
Senior Instructor of Pediatrics
Catherine Hovey, RN
Instructor of Pediatrics
Annie Immele, MSW
Senior Instructor of Pediatrics
Terry F. Katz, PhD++•
Instructor of Pediatrics
Hal Lewis, PhD
Associate Professor of Psychiatry
Sandra Link, OT
Instructor of Pediatrics
Maria Marin, MSW
Senior Instructor of Pediatrics
Michael Maza, MSW, MS
Senior Instructor of Pediatrics
Marguerite Monson, BS, OTR
Instructor of Pediatrics
Tracy Price-Johnson, BA
Instructor of Pediatrics
Judy Reaven, PhD
Assistant Professor of Psychiatry
and Pediatrics
Ann M. Reynolds, MD+•
Assistant Professor of Pediatrics
Director, Child Development Unit
Cheryl Rooke, MA, CCC-SLP
Senior Instructor of Pediatrics
Steven Rosenberg, PhD
Associate Professor of Psychiatry
Debra Schell-Frank, EdD
Senior Instructor of Pediatrics
Kelly Stainback-Tracy, MPH, PT
Instructor of Pediatrics
Secondary Appointments
Marilyn Krajicek, RN, EdD, FAAN
Professor of Nursing and Assistant
Clinical Professor of Pediatrics
Mary Jane Rapport, PhD, PT
Professor of Rehabilitation Medicine
and Pediatrics
Ayelet Talmi, PhD
Assistant Professor of Psychiatry
and Pediatrics
Fellows
Jamie Condo, MA, CCC-SLP
(2005-2006)
Jack Davis, MBA (2008-2009)
Leslie Drage, MA, CCC-SLP
(2006-2007)
Lila Kimel, MA (PhDc.) (2007-2008)
Eileen Leuthe, PhD (2008-2009)
Stephanie Lyle, DPT (2008-2009)
Megan Martins, PhD (2007-2009)
Eric Moody, PhD (2008-2011)
Joely Neptune, MA, CCC-SLP
(2007-2009)
Shana Nichols, PhD (2005-2006)
Nancy Raitano Lee, PhD (2005-2007)
Sara Rode, MA, CCC-SLP (2006-2007)
Samantha Simms Piper, PhD
(2005-2007)
Norbert Soke, MD, PhD (2008-2009)
Amanda Vargo, MS, CCC-SLP
(2008-2009)
Kathleen Wehrman, PhD
(2008-2009)
Clinical and Research Staff
Jennifer Baltz, BA
Professional Research Assistant,
Psychiatry
Teri Brogdon, MA
Senior Professional Research
Assistant, Psychiatry
Janet Campbell, MA
Clinical Senior Instructor
of Pediatrics
Andrea Cantarero, BS
Professional Research Assistant,
Psychiatry
Dylan Carelli, BA
Professional Research Assistant,
Pediatrics
Jean Cimino, MPH
Professional Research Assistant,
Pediatrics
1 24 D e p a r t m e n t o f P e d i a t r i c s
Katy Ridge, BS
Professional Research Assistant,
Psychiatry
Geraldine Steinke, PhD
Clinical Senior Instructor of
Pediatrics and Research Associate,
College of Nursing
Lori Zugich
Professional Research Assistant,
Psychiatry
Administration
Kim Pierpoint, MSPH
Administrator
Rob Murchison, BS
Finance Manager
Beverley Murdock
Autism and Developmental
Disabilities Clinic Intake
Coordinator
Sandi Riedel-Fitzgerald
Autism and Developmental
Disabilities Clinic Program
Assistant
+
Intellectual and Developmental
Disabilities Research Center Faculty
++
The Children’s Hospital Sleep
Center Faculty
• Developmental and Behavioral
Pediatrics Faculty
Pediatric Heart Lung Center
Program Overview
The Pediatric Heart Lung Center (PHLC) was initiated
12 years ago in order to develop innovative approaches
towards the investigation and treatment of severe cardiac and pulmonary disorders in children. The overall
purpose of the Center is to establish a multidisciplinary
program to stimulate new understanding and novel
strategies for the treatment of childhood cardiovascular
and pulmonary diseases. The approach is to foster the
integration of basic and clinical sciences, as well as the
development of multidisciplinary approaches to these
diseases, by integrating key personnel from different
sections within the Department of Pediatrics. The rationale for the program is that:
1.current treatments of many life-threatening cardiovascular pulmonary diseases are limited by a lack
of insight into the fundamental pathophysiologic
mechanisms underlying these disorders;
2.insufficient dialogue between scientists involved
with basic laboratory research and physicians
primarily involved in patient care and clinical
research limits the bedside applications of new
therapies and impedes the design of clinically
relevant bench research;
programs
Pediatric Heart Lung Center Front row, l - r: Jennifer Geppner, Michelle Calderbank, Renee Rietsch, Donna Parker, Joy Browne,
Vivek Balasubramaniam; Back row, l - r: D. Dunbar Ivy, Kathleen Miller-Reed, Beth Coleman, John Kinsella, Steven Abman, Peter Mourani
3.traditional clinical training within each discipline is
Research
generally too narrow in scope to help improve treat-
Research in the PHLC includes diverse approaches to
ments of complex cardiopulmonary disorders; and
acute lung injury, neonatal pulmonary hypertension,
4.multidisciplinary approaches will lead to greater
respiratory distress syndrome in premature newborns,
advances in the study and management of childhood
postoperative cardiac care, long-term management of
cardiopulmonary diseases.
pulmonary hypertension, and other areas.
As a result, the PHLC’s approach is to improve the
Current studies include:
clinical care and outcomes of children with diverse
n
cardiopulmonary diseases by promoting:
n
improvements in current clinical care
n
n
basic science laboratory investigations
single-center physiologic and outcome studies
multicenter randomized clinical trials
basic and clinical research
n
multidisciplinary training for students, residents,
n
and fellows
novel educational approaches to cardiovascular and
n
pulmonary disorders
initiation of new and creative research approaches
n
Current topics of interest in the basic science
laboratories include:
mechanisms of lung vascular development
n
alveolar growth
n
growth factors in lung development and pulmonary
n
and programs
development of new clinical approaches to
n
cardiopulmonary disease
hypertension
endothelial cell function in the developing lung
n
roles of nitric oxide in the pathophysiology and
n
treatment of neonatal lung diseases
By supporting programs that link bench research with
n
bedside clinical care and clinical investigation, the PHLC
n
mechanisms of acute lung injury
role of progenitor cells during lung development and
provides an environment that promotes more rapid clin-
in the pathogenesis and treatment of childhood lung
ical application of “cutting-edge” technologies.
diseases, including pulmonary hypertension, BPD,
and others
2006-2008 Departmental Report
125
programs
Clinical studies include:
multicenter trials in the use of inhaled nitric oxide
n
(iNO) to prevent bronchopulmonary dysplasia in
premature babies
the role of iNO therapy with high-frequency oscilla-
n
tion in the treatment of pediatric respiratory failure
single-center studies of the safety, feasibility, and effi-
n
cacy of home NO therapy and the effects of pulsed
iNO therapy in postoperative cardiac patients
treatment of pulmonary hypertension in BPD
n
biomarkers and genetic susceptibility in premature
n
infants at risk for BPD
the role of new oral agents for the treatment of
n
chronic pulmonary hypertension
Faculty research interests are listed in each investigator’s
section/program.
Education
The Pediatric Heart Lung Center (PHLC) actively
promotes research, education, and training in cardiorespiratory disorders of newborns, infants, and children.
The PHLC trains fellows, residents, medical students,
respiratory therapists, and nurses. The PHLC provides
extensive research training in the laboratory with diverse
Pediatric Heart Lung Center Faculty
Faculty
Steven H. Abman, MD*•
Professor of Pediatrics
Director, Pediatric Heart Lung Center
Christopher D. Baker, MD*•
Assistant Professor of Pediatrics
Vivek Balasubramaniam, MD*•
Associate Professor of Pediatrics
Director, Pediatric Heart Lung
Center Laboratory
Emily L. Dobyns, MD••
Associate Professor of Pediatrics
Director, Education
Medical Director, Pediatric
Intensive Care Unit
Theresa R. Grover, MD*•
Associate Professor of Pediatrics
D. Dunbar Ivy, MD•
Professor of Pediatrics
Section Head, Cardiology
Selby’s Chair in Pediatric Cardiology
Director, Pulmonary Hypertension
Program
John P. Kinsella, MD*•
Professor of Pediatrics
Director, Clinical Research
Peter M. Mourani, MD••
Assistant Professor of Pediatrics
Thomas A. Parker, MD*•
Associate Professor of Pediatrics
Director, Neonatal Education
Clinical Staff
Michelle Calderbank, RN, BSN
Aimee Doran, RN, MSN, CPNP
Lucy Fashaw, RN, BSN
Jen Geppner, RN, MSN, CPNP
Kathy Hale, RN, BSN
Kathleen Miller-Reed, RN, BSN
Susan Moreland, MS, NNP
Donna Parker, RRT
Renee Rietsch, RN, MSN, CPNP
Laura Tucker, RN, MSN, CPNP
Nancy Waas, RN
Research Staff
Kelley Colvin, MS
Professional Research Assistant
Neil Markham, BS
Senior Professional Research
Assistant
Emily Roth, BS
Professional Research Assistant
Sharon Ryan, BS
Professional Research Assistant
Gregory Seedorf, BS
Professional Research Assistant
Ben Wisniewski, BS
Professional Research Assistant
* Pulmonology Faculty
* Neonatology Faculty
• Perinatal Research Center Faculty
• Cardiology Faculty
•• Critical Care Medicine Faculty
models of pulmonary vascular development, pulmo-
Perinatal Research Center
nary hypertension, neonatal lung injury, chronic lung
Program Overview
disease, and others. Laboratory methods include whole
The Perinatal Research Center (PRC) is the longest
animal models utilizing perinatal sheep, rats, and mice;
standing research and educational program at the
isolated vascular and airway cells; stem or progenitor
University of Colorado Denver’s Anschutz Medical
cells; and related molecular, biochemical, and morpho-
Campus. Faculty who conduct studies at the Center are
metric approaches. Didactic sessions include laboratory
on the leading edge of research in maternal, placental,
meetings, weekly research symposia, and other meet-
and fetal physiology.
ings. Translational research is also emphasized in these
The PRC supports the Division of Perinatal Medicine,
research conferences. The PHLC also holds weekly clini-
which is jointly managed by the Departments of Pediatrics
cal meetings for our Pulmonary Hypertension Program
and Obstetrics and Gynecology. Other primary partici-
and multidisciplinary Ventilator Care Program.
pating research and educational programs include the
Pediatric Heart Lung Center and the Developmental
Lung Biology Laboratory.
Research at the PRC primarily involves reproductive
and developmental physiology and biochemistry. The
1 26 D e p a r t m e n t o f P e d i a t r i c s
programs
Perinatal Research Center Front row, l - r: Russell Anthony, Michael Owoeye, Jason Gien, Mizanoor Rahman, Juan Arroyo;
Middle row, l - r: Bonnie Savone, Jann Rhodes, Stephanie Thorn, Julie Torvik, Nancy (Pi-Ou) Tseng, Maria Vallejo, Georgina Garza, Barbara Falk;
Back row, l - r: Jacob Friedman, Laura Brown, Jennifer Corwin, Gates Roe, Alex Cheung, William Hay, Jr.
research is conducted in pregnant sheep, an internation-
ees, and clinical and basic scientists. The purpose of
ally recognized standard model for studying maternal,
the training program is to provide basic and clinical
placental, and fetal physiology. The principal aims of the
postdoctoral research training for neonatology and
research are to better understand the processes involved
maternal-fetal medicine physicians and basic scientists
in fetal growth and development and the mechanisms
who have completed residency training or a PhD degree.
that regulate such growth and development under nor-
The research training includes concepts and techniques
mal and pathological conditions. Additionally, the stud-
in perinatal/developmental physiology, biochemistry,
ies of fetal growth provide a greater understanding of
cell and molecular biology. Training is for three years
how aberrant fetal growth can lead to poor reproductive
in preparation for academic careers in reproductive
outcome (such as intrauterine growth restriction), neona-
medicine within the Departments of Pediatrics and
tal disease (such as persistent pulmonary hypertension),
Obstetrics and Gynecology. During the first year, which
and adult disorders that have their origins during fetal
is largely clinical and is not funded by the NIH Training
life (such as obesity, insulin resistance, diabetes, hyper-
Grant in Perinatal Medicine, trainees work with faculty
tension, and cardiovascular disease). All of the research
advisors to select basic research projects and mentors.
is supported by nationally competitive grants.
Three areas of research are offered: 1) fetal nutritional
metabolism and growth; 2) placental development and
Faculty research interests are listed in the Section of
function; and 3) vascular development and regulation of
Neonatology.
blood flow. Each area includes clinical, whole animal,
organ, cell, and molecular research so that a trainee
Education
can participate at any one or several levels of biological
The PRC provides a unique basic biology training
investigation. Trainees attend seminars that review intra-
program for students, clinical and basic science train-
uterine development and fetal, maternal, and neonatal
2006-2008 Departmental Report
127
programs
physiology. Courses in the graduate school dealing with
cell culture, genetics, developmental biology, cell and
molecular biology, isotope applications, biostatistics,
data processing and informatics, statistics, graphics,
bioethics, and ethical conduct of research are included.
Seminar programs in research design and abstract
and manuscript preparation are provided. The second
and third years, funded by the NIH Training Grant in
Perinatal Medicine, are devoted to the completion of the
basic research projects begun in the first year and expansion into new areas of research and research techniques.
Each trainee develops institutional animal and clinical
research protocols to address ethical issues involved in
research. Trainees plan and conduct their research projects independently, but with full faculty guidance. This
program provides multidisciplinary training in basic and
clinical biological investigation, integrating state-of-theart research techniques with important questions in perinatal medicine and biology. This approach equips the
trainees with the capacity to move independently and
Frederick C. Battaglia, MD*
Professor Emeritus of Pediatrics
Laura D. Brown, MD*+
Assistant Professor of Pediatrics
Jacob E. Friedman, PhD*+
Associate Professor of Pediatrics,
Biochemistry and Molecular
Genetics
Director, Molecular Biology Core
Labs for UCD Training Program
in Perinatal Medicine and Biology
Director, Core Lab for Perinatal
Emphasis Research Center Grant
Henry L. Galan, MD
Associate Professor of Obstetrics
and Gynecology
Director, Maternal-Fetal Medicine
Jason Gien, MD*
Assistant Professor of Pediatrics
Theresa R. Grover, MD**
Associate Professor of Pediatrics
John P. Kinsella, MD**
Professor of Pediatrics
Director, The Children’s Hospital
Newborn ECMO Service
Director, Pediatric Medical Advisory
Group, Newborn/Young Child
Team, Flight for Life
successfully into academic careers.
Trina Knotts, PhD
Research Instructor of Pediatrics
Highlights
Giacomo Meschia, MD
Professor Emeritus of Pediatrics
and Physiology
Laura Brown was chosen as a Building Interdiscliplinary
n
Research Careers in Women’s Health K12
(BIRCWH) Scholar.
Paul Rozance was identified as a “Rising Investigator”
n
by the Perinatal Research Society and received a
Junior Faculty Award from the American Diabetes
Association.
Perinatal Research Center Faculty
Faculty
William W. Hay, Jr., MD*++
Professor of Pediatrics
Scientific Director, Perinatal
Research Center
Co-Director, Colorado Clinical
Translational Sciences Institute
Director, Child and Maternal
Health Research, Colorado Clinical
Translational Sciences Institute
Steven H. Abman, MD**
Professor of Pediatrics
Director, Pediatric Heart Lung Center
Russell V. Anthony, PhD*
Associate Professor of Pediatrics
Hill Professor of Animal
Biotechnology, Colorado State
University
Juan A. Arroyo, PhD
Instructor/Fellow of Obstetrics
and Gynecology
Vivek Balasubramaniam, MD**
Assistant Professor of Pediatrics
James S. Barry, MD*
Assistant Professor of Pediatrics
1 28 D e p a r t m e n t o f P e d i a t r i c s
Thomas A. Parker, MD**
Associate Professor of Pediatrics
Director, Neonatal-Perinatal Medicine
Fellowship Training Program
Director, Neonatal Education
Mohammed Qadri, PhD
Senior Research Instructor
of Pediatrics
Timothy Robert Hume Regnault, PhD*
Adjoint Assistant Professor of Pediatrics
Paul J. Rozance, MD*
Assistant Professor of Pediatrics
Danielle Smith, MD*
Senior Instructor of Pediatrics
Patti J. Thureen, MD*+++
Professor of Pediatrics
Co-Director, Child and Maternal
Health Research, Colorado Clinical
Translational Sciences Institute
Randall B. Wilkening, MD*
Professor of Pediatrics
Section Head, Neonatology
Vice Chair, Clinical Practice
Fellows
Cassidy Delaney, MD (2007-2010)
Mackenzi Frost, MD (2005-2009)
Pastora Garcia Jones, MD
(2006-2009)
Beena D. Kamath, MD, MPH
(2005-2009)
Jinny Lavezzi, MD (2008-2011)
Robert Rock, MD (2007-2010)
Susan Soto, MD (2008-2011)
Jen-Ruey Tang, MD (2005-2008)
Stephanie Thorn, PhD (2008-2009)
Hillary Tuttle, MD, PhD (2007-2010)
Amy Wood, MD (2009)
Rachel Wright, MD (2008-2011)
Erica Wymore, MD (2006-2009)
Research Staff
David Caprio, BA
Senior Professional Research
Assistant
Alex Cheung, PhD
Senior Professional Research
Assistant
Darleen Cioffi-Ragan, CRT
Becky De la Houssaye, MS
Senior Professional Research
Assistant
Georgina Garza
Rachel Janssen, MS
Senior Professional Research
Assistant
Dan LoTurco, BS, MS
Professional Research Assistant
Jann Rhodes, PhD
Gates Roe, BA
Professional Research Assistant
Cecilia Teng, MS
Senior Professional Research
Assistant
Karen Trembler, BS
Senior Professional Research
Assistant
* Pediatric Heart Lung Center
Faculty
* Pulmonology Faculty
* Neonatology Faculty
+
Intellectual and Developmental
Disabilities Research Center Faculty
+
Nutrition Faculty
++
TCH Clinical Translational
Research Center Faculty
programs
advocate program, and a Scientific Advisory and Review
Committee (SARC). Excellence in research is promoted
through the highest level of scientific design, with participant safety and confidentiality our highest priorities.
Research
The TCH CTRC supports between 125-150 active
protocols at any one time. Currently, there are 49 investigators with active protocols. Among currently active
TCH CTRC protocols, the following ongoing research
The Children’s Hospital Clinical Translational Research Center
(CTRC) Front row, l - r: Diane Branham, Peggy Emmett, D. Jane Gralla,
Janine Higgins; Back row, l - r: Ronald Sokol, Theresa O’Lonergan,
Kristen Benn, Jeffrey Magouirk
protocols were approved by the TCH CTRC Scientific
Advisory and Review Committee in 2007:
Frank J. Accurso, MD
n
n
The Children’s Hospital Clinical
Translational Research Center
A Double-Blind, Multicenter, Multinational,
Randomized, Placebo-Controlled Trial Evaluating
Aztreonam Lysine for Inhalation in Patients
Clinical Services
with Cystic Fibrosis, Mild Lung Disease, and
The Children’s Hospital Clinical Translational Research
Pseudomonas aeruginos
Center (TCH CTRC) is part of the newly funded
n
A Randomized, Double-Blind, Placebo-Controlled,
Colorado Clinical and Translational Sciences Institute
Multicenter, Crossover Study to Evaluate the
(CCTSI) supported by the NIH as part of the nation-
Effectiveness and Safety of PANCRECARB MS-16
wide Clinical and Translational Science Award (CTSA)
(Pancrelipase) in Reducing Steatorrhea in Children
program. The Pediatric CTRC had been continuously
and Adults with Cystic Fibrosis
funded since 1962 by an NIH GCRC grant. The Center
n
A Phase III, Randomized, Double-Blind, Placebo-
is now supported by the University of Colorado Denver
Controlled Clinical Study Evaluating the Efficacy
CTSA NIH grant, funded for five years from 2008 to
and Safety of ALTU-135 Treatment in Patients
2013.
with Cystic Fibrosis-Related Exocrine Pancreatic
The TCH CTRC is one of four CTRCs that form the
Insufficiency
CTRC network within the CCTSI. While the first pri-
n
A Phase I/II Randomized, Double-Blind, Placebo-
ority is to provide exemplary patient care and research
Controlled, Single-Dose, Dose Escalation Study
nursing for children admitted under research protocols,
of KB001 in Cystic Fibrosis Patients Infected with
the inpatient unit is also active in providing care for non-
Pseudomonas aeruginos
Susan Apkon, MD
research patients, including care for patients with cystic
n
fibrosis. Clinical research resources also include perinatal
Estimation of the Energy Savings Attributed to
and pediatric “scatterbed” nurses and a new outpatient
Control of Spasticity in Children with Cerebral Palsy
research clinic. In addition to 18 research nurses, the
Using an Intrathecal Baclofen Pump
Jennifer M. Barker, MD
activities of the TCH CTRC are supported by a research
n
bionutrition core and a core laboratory, as well as ser-
Oral Insulin for the Prevention of Diabetes in
vices offered through the CCTSI, including a bioinfor-
Relatives at Risk for Type 1 Diabetes Mellitus
matics core, biostatistical services, a research subject
2006-2008 Departmental Report
129
programs
Frederick C. Battaglia, MD
n
Transplacental Gradients,Transport, and Production
Ulrich Klein, DDS
n
Immunological Marker Assays in Children Receiving
of Polyols and Manose in Normal and IUGR
Dental Rehabilitation Under General Anesthesia
Pregnancies
Before and After Extraction: A Pilot Study
Melissa A. Cadnapaphornchai, MD
n
Nancy F. Krebs, MD
n
Pharmacologic Treatment of Congenital Nephrogenic
Meeting Zinc (Zn) and Iron (Fe) Requirements
Diabetes Insipidus
for Older Breastfed Infants: Comparison of
Complementary Feeding Strategies
James Carollo, PhD, PE
n
Rhythmic Auditory Stimulation as a Gait Intervention
Myron J. Levin, MD
n
IMPAACT P1065: Phase I/II Study of Safety and
for Children with Cerebral Palsy
Immunogenicity of Quadrivalent Meningococcal
Emily L. Dobyns, MD
n
Conjugate Vaccine in HIV-Infected Youth
Evaluation of Adrenal Reserve and Response to
Low-Dose ACTH (Corticotrophin) Stimulation in
David M. Maahs, MD
n
Trial of Zocor and Vytorin in Adolescents with
Critically Ill Children
Type 1 Diabetes
Rosanna V. Fiallo-Scharer, MD
n
n
The Effect of Using Terbutaline or a Reduction
Elizabeth McFarland, MD
n
in Basal Insulin Infusion as a Therapeutic Agent
n
n
Surveillance Monitoring for ART Toxicities Study
to Prevent Delayed Nocturnal Hypoglycemia in
in HIV-uninfected Children Born to HIV-infected
Children and Adolescents with Type 1 Diabetes
Women (SMARTT Study)
Reversal of Hypoglycemia Unawareness Using
n
IMPAACT P1066: Phase I/II Multicenter, OpenLabel, Noncomparative Study of the International
Continuous Glucose Monitoring
Maternal, Pediatric, Adolescent AIDS Clinical
Robert Friesen, MD
n
Depth of Anesthesia and the Incidence of Emergence
Trials (IMPAACT) Group to Evaluate the Safety,
Agitation and Post-Operative Behavioral Changes in
Tolerability, Pharmacokinetics, and Antiretroviral
a Population of Pediatric Dental Patients
Activity of Raltegravir (MK-0518) in HIV-1 Infected
Children and Adolescents
Robin L. Gabriels, PsyD
n
Evaluating the Effects of a Visual Pedagogy and
James McManaman, MD
n
March of Dimes UCD Preterm Birth Biomarker Study
Structure on the Successful Completion of the
Medical Office Visit and Physical Examination with
Lisa Miller, MD
n
National CADDRE Study: Child Development
Pre-Pubescent Children with Autism
and Autism
Peter A. Gottlieb, MD
n
Effects of CTLA4-log (Abatacept) on the Progression
of Type 1 Diabetes in New Onset Subjects
Elaine H. Morrato, DrPH
n
Periodontal Health Status of Adolescents with
Type 1 Diabetes
D. Dunbar Ivy, MD, and David Badesch, MD
n
Treatment of Pulmonary Hypertension and Sickle
Michael R. Narkewicz, MD
n
Fecal Behenic Acid: A New Marker for Fat
Cell Disease with Sildenafil Therapy
Malabsorption
John P. Kinsella, MD
n
Pilot Trial of rhSOD in Term Newborns with PPHN
Rachelle Nuss, MD
n
Effectiveness of Hydroxyurea and Magnesium
Pidolate Alone and in Combination in Hemoglobin
SC Disease A Phase II Trial
1 30 D e p a r t m e n t o f P e d i a t r i c s
programs
David Partrick, MD, and Robert McIntyre, MD
n
Marci Sontag, PhD
n
The Effect of Blunt Trauma and Burn Injury on the
Inflammatory Response in Pediatric Patients
Gene Modifiers of Early CF Pulmonary Disease
Shikha S. Sundaram, MD, MSCI
n
David Polaner, MD
Isoprostanes: A Marker of Oxidative Injury in Fatty
n
Does Total Intravenous Anesthesia with Propofol for
Greater than 4 Hours Produce Occult Biochemical
Liver Disease
Joanne Valvano, PhD
n
Measurement of Voluntary Motor Control in
Evidence of the Propofol Infusion Syndrome?
Melanie S. Reece, PhD, and
the Affected Upper Extremity of the Child with
n
Linda A. Barbour, MD, MSPH
Regulation of Maternal Fuel Supply and Neonatal
Hemiplegic Cerebral Palsy
R. Paul Wadwa, MD
n
Determinants of Macrovascular Disease Risk in
Adiposity
Tonia M. Sabo-Graham, MD
Adolescents with Type 1 Diabetes
n
Pilot Study to Define Nutritional Interrelationships
Lisa Willis, MD
n
of CoQ10, Riboflavin, and Magnesium in the
Assessment of Feeding Tolerance in Neonates with
Evaluation and Treatment of Childhood Migraine
Ductal Dependent Cardiac Defects While Receiving
Headaches
Prostaglandin Therapy
Scott D. Sagel, MD
n
n
n
n
n
Edith Zemanick, MD
n
Longitudinal Study of Primary Ciliary Dyskinesia:
Early Staphylococcal and Polymicrobial Bacterial
Participants 5-18 Years of Age
Infection in CF
A Phase 2a, Randomized, Double-Blind, PlaceboControlled Study of VX-770 to Evaluate Safety,
Education
Pharmacokinetics, and Biomarkers of CFTR Activity
The TCH CTRC is involved in research training across
in Cystic Fibrosis (CF) Subjects with Genotype
multiple disciplines and levels, ranging from medical
G551D
students to clinical fellows to junior faculty. Rotations
Safety and Efficacy of a Novel Antioxidant-Rich
available in the different TCH CTRC cores include
Multivitamin Supplement for Persons with Cystic
a dietetic internship rotation; a core laboratory rota-
Fibrosis
tion for premedical students, graduate students in the
Multicenter Trial to Validate Protein Biomarkers of a
Clinical Sciences Program (PhD/Certificate in Clinical
Pulmonary Exacerbation in Cystic Fibrosis
Sciences Program), and pulmonology fellows; a nursing
Teresa A. Sharp, PhD
n
student rotation on the TCH CTRC Inpatient Unit; and
Endothelial Function and its Relationship to
a biomedical ethics internship. Medical students at UCD
Cardiovascular Disease Risk Factors in Lean and
or other institutions across the country may spend elec-
Overweight Pre- and Early-Pubertal Children
tive time on the TCH CTRC, during which they have
Ronald J. Sokol, MD
n
n
Randomized, Double-Blind, Placebo-Controlled
the option to participate in projects under a mentor.
Pediatric residents have direct contact with the TCH
Trial of Corticosteroid Therapy Following
CTRC during their care of TCH CTRC patients while
Portoenterostomy in Infants with Biliary Atresia
rotating on the inpatient pediatric ward service at TCH.
n
Biliary Atresia Study in Infants and Children (BASIC)
Residents in the Opportunities in Resident Research
n
Longitudinal Study of Genetic Causes of Intrahepatic
program may become involved in or design a research
Cholestasis
project to be completed during their residency, under the
2006-2008 Departmental Report
131
programs
supervision of a research mentor. In addition, CCTSIfunded trainees (K12 awardees and T32 awardees) use
Rhonda Knapp-Clevenger,
RN, CPNP, MSN
Senior Instructor of Pediatrics
the TCH CTRC for performing clinical and translation-
Arthur Cook
al research while in training.
Stephanie Jones
Courtney Knapp
Highlights
Nancy H. Waas, RN, BSN
The Colorado Clinical and Translational Sciences
n
Institute (CCTSI) was funded for five years by the
NIH in May 2008, becoming one of 38 Clinical and
Translational Science Awardees (CTSA) in the U.S.
The TCH CTRC is one of four CTRCs that form the
Nutrition
Janine A. Higgins, PhD+
Assistant Professor of Pediatrics
Melanie Kasten, BS
Trinda Windle
n
CTRC network within the CCTSI.
Ronald J. Sokol, MD, Section Head of
n
Gastroenterology, Hepatology and Nutrition in the
Department of Pediatrics, is the Principal Investigator
and Director of the CCTSI.
TCH CTRC Faculty
Faculty
Ronald J. Sokol, MD••
Professor of Pediatrics
Vice Chair, Clinical and
Translational Research
Program Director, TCH CTRC
Director, Colorado Clinical and
Translational Sciences Institute
Section Head, Gastroenterology,
Hepatology and Nutrition
Frank J. Accurso, MD*
Professor of Pediatrics
Core Laboratory Medical Director,
TCH CTRC
Co-Director, Cystic Fibrosis Center
Section Head, Pulmonology
William W. Hay, Jr., MD*•
Professor of Pediatrics
Co-Director, Colorado Clinical and
Translational Sciences Institute
Director, Child and Maternal Health
Research, Colorado Clinical and
Translational Sciences Institute
Patti J. Thureen, MD*•+
Professor of Pediatrics
Co-Director, Child and Maternal
Health Research, Colorado Clinical
and Translational Sciences
Institute
Philip S. Zeitler, MD, PhD**••
Professor of Pediatrics
Medical Director, TCH CTRC
Research Staff
Nursing
Diane Branham, RN, BSN
Senior Instructor of Pediatrics
Nursing Manager
Caitlin J. Burnett, RN, BSN
Virginia Weissman, RN, BSN
Jin-Qiu Yang, RN, MSN
Sonia Anders, RN, BSN
Mary Beth Davenport, RN, BSN
Lisa M. Lewis, RN, BSN
Jessica VanderKwaak, RN, BSN
Kelly Freng, RN, BSN
CTRC Core Laboratory and
Cystic Fibrosis Resource Lab
Peggy Emmett, MT (ASCP)
Mary Jo Harrington, MT (ASCP)
Heidi Rehman, MS
Thu Phan, BS
D. Jane Gralla, PhD+
Assistant Professor of Pediatrics
Assistant Professor of Biostatistics
and Informatics, Colorado School
of Public Health
Biostatistician
Jeri E. Forster Harwood, PhD+
Assistant Professor of Pediatrics
Assistant Professor of Biostatistics
and Informatics, Colorado School
of Public Health
Biostatistician
Zhaoxing Pan, MB, PhD+
Instructor of Pediatrics
Instructor of Biostatistics and
Informatics, Colorado School
of Public Health
Biostatistician
Research Subject Advocacy
Theresa A. O’Lonergan, MA
Senior Instructor of Pediatrics
Biomedical Informatics
Michael G. Kahn, MD, PhD*+
Associate Professor of Pediatrics
Co-Director, Colorado Clinical and
Translational Sciences Institute
Biomedical Informatics Program
Director, Colorado Clinical and
Translational Sciences Institute
Administrative Staff
Kristin Benn, BS
Rose Heineman
Cindy Scott, BS
Elle Lothlorien
Tracy Scheidman
Stacie Kilgore
Jeffrey Magouirk, MS
Instructor of Pediatrics
* Pulmonology Faculty
* Neonatology Faculty
* Epidemiology Faculty
**Barbara Davis Center for
Swan Ellert
Biostatistics
Dexiang Gao, PhD+
Instructor of Pediatrics
Instructor of Biostatistics and
Informatics, Colorado School of
Public Health
Biostatistician
Childhood Diabetes Faculty
Nutrition Faculty
+
TCH Research Institute Faculty
• Perinatal Research Center Faculty
•• Gastroenterology, Hepatology
and Nutrition Faculty
•• Endocrinology Faculty
+
Jennifer Ibsen, RN, BSN
Amy Arnold, RN, BSN
Mario Alfaro, RN, BSN, MSN
The Children’s Hospital
Research Institute
Andria L. Redman, RN, BSN
Inpatient Clinical Coordinator
The Children’s Hospital Research Institute (TCHRI)
Mary Hawes, RN, BSN
Program Overview
Christine Reed, RN, ND
serves The Children’s Hospital (TCH) by assisting
Donna Rodden, RN, BSN
Assistant Nursing Manager
investigators in the conduct of responsible and ethical
Lucy Fashaw, RNC, BSN
Kathy A. Hale, RN, BSN
Barbara A. Pruckler, RN, BSN
Jacqueline A. Sammons, RN
1 32 D e p a r t m e n t o f P e d i a t r i c s
research, including human subject research at TCH.
TCH is a member of the Colorado Multiple Institutional
Review Board (COMIRB), the local regulatory agency
responsible for the review of all human subject research.
Members of TCHRI are available for consultation
programs
property, and a proper liaison between the principal
investigators and the various departments at the hospital; 2) A compliance arm that facilitates safe and ethical
studies. TCHRI serves as a focal point for the review
of human subjects research; 3) A biostatistical core that
helps with study design, data acquisition, and interpretation of results. This group of experienced statisticians is
available to any member of the TCH community who
is in need of study design assistance; and 4) A Clinical
Informatics (CI) group that can assist PI’s with research
data management. CI extracts clinical information from
The Children’s Hospital Research Institute Front row, l - r:
Louisa Cardenas, Maureen Ishii, Terri Robles; Middle row, l - r: Jeri
Harwood, Catie Deines, Dexiang Gao, D. Jane Gralla; Back row, l - r:
Lia Apostolellis-Butler, John Dutton, David Lawellin, Paul Fennessey
institutional data sources for operational and research
purposes.
In addition to providing infrastructure for research,
TCHRI has assumed additional roles at The Children’s
on the preparation and submission of materials to
Hospital (TCH). Approximately nine years ago, a
COMIRB. COMIRB-approved pediatric protocols are
Clinical Trials Organization (CTO) was established at
maintained in TCHRI as part of its responsibilities to
TCH. This group facilitates industry-sponsored research
TCH. Many projects funded by TCHRI through its
at the hospital. TCHRI acts as a financial underpinning
internal awards, (pilot, research scholar, and nursing
for the CTO. Likewise, the opportunity to establish the
research awards), are human subject-related. TCHRI
Children’s Outcome Research Program (COR) at TCH
personnel are available to assist in the interpretation of
was realized when TCHRI made a long-term commit-
the regulations regarding Protected Health Information
ment to offset the administrative needs of the program.
(PHI, HIPAA) and research. Requests for preparatory
and decedent research must be approved by TCHRI.
One of the major activities of TCHRI is the funding
of the creative new ideas and projects of faculty and
TCHRI is the umbrella organization for the Clinical
staff. TCHRI has developed a number of funding pro-
Trials Organization (CTO) at TCH. TCHRI works close-
grams for completely new ideas (Pilot Grant Awards);
ly with the staff of the CTO to prepare budgets, ensure
for the development of new faculty and staff until such
proper protection of intellectual property, and maintain
time as they are ready to compete for external awards
proper liaisons with various ancillary departments (phar-
(Research Scholar Awards); for projects that help the
macy, pathology laboratories, radiology, and the TCH
hospital discover better ways to provide care to our
Clinical Translational Research Center). Many projects
patients (Quality Systems Improvement Awards); and
funded by TCHRI involve direct patient care.
for nurses who need assistance to translate a good idea
into an active research protocol (Small Nursing Grants).
Research
In the event that an investigator loses their funding,
The TCHRI was established to facilitate the scientific
TCHRI is available to provide temporary funds until the
and clinical investigations of our faculty and staff. Its
external source is reestablished (Bridge Fund Awards).
infrastructure is composed of the following: 1) A grants
Between 2006 to 2008, TCHRI awarded approxi-
management group that is involved in all aspects of the
mately $1.2 million each year to members of the staff
development and execution of external funding, includ-
and faculty. This initial investment allowed our inves-
ing preparation of budgets, protection of intellectual
tigators to collect the necessary preliminary data to be
2006-2008 Departmental Report
133
programs
competitive nationally in their applications for funding
to outside agencies such as NIH. Each of these external
grants involves expenses ranging from fifty thousand
to one million dollars and allows our scientists to make
the innovative discoveries that will bring the cures of
today’s diseases within our reach and provide the new
treatments for children’s diseases tomorrow.
The Children’s Hospital Foundation and The
Children’s Hospital Board of Directors have been key
supporters of the TCHRI and its operations. TCH’s
financial support has been instrumental in both the
recruitment and retention of research faculty.
Faculty research interests are listed in each
investigator’s program.
TCHRI Faculty
Faculty
Paul V. Fennessey, PhD**+++
Professor of Pediatrics and
Pharmacology
Vice Chair, Research
Richard E. Davis, PhD
Associate Professor of Pediatrics
David Lawellin, PhD
Senior Instructor of Pediatrics
Research Resource Coordinator
Biostatistics Core
Dexiang Gao, PhD++
Instructor of Pediatrics
Instructor of Biostatistics and
Informatics, Colorado School
of Public Health
Biostatistician
D. Jane Gralla, PhD++
Assistant Professor of Pediatrics
Assistant Professor of Biostatistics
and Informatics, Colorado
School of Public Health
Biostatistician
++
Jeri E. Forster Harwood, PhD
Assistant Professor of Pediatrics
Assistant Professor of Biostatistics
and Informatics, Colorado
School of Public Health
Biostatistician
Zhaoxing Pan, MB, PhD++
Instructor of Pediatrics
Instructor of Biostatistics and
Informatics, Colorado School
of Public Health
Biostatistician
Grants Program Administration
Lia Apostolellis-Butler
Research Coordinator
Louisa M. Cardenas
Post-Award Accountant
Catie L. Deines, BS, CPhT, CCRC
Research Associate
Elaine H. Morrato, DrPh*
Assistant Professor of Pediatrics
Assistant Professor of Clinical
Pharmacy, School of Pharmacy
Assistant Professor of Health
Systems, Management, and
Policy, Colorado School of
Public Health
James K. Todd, MD**++
Professor of Pediatrics and
Microbiology
Professor of Epidemiology,
Colorado School of Public Health
Section Head, Epidemiology
(Pediatrics)
Vice Chair, Advocacy (Pediatrics)
Jules Amer Chair in Community
Pediatrics
Director, Epidemiology, Clinical
Outcomes and Clinical
Microbiology, The Children’s
Hospital
Clinical Informatics
Michael G. Kahn, MD, PhD*++
Associate Professor of Pediatrics
Co-Director, Colorado Clinical
and Translational Sciences
Institute
Biomedical Informatics Program
Director, Colorado Clinical and
Translational Sciences Institute
Director, Clinical Informatics, Quality
and Patient Safety, The Children’s
Hospital
Deborah Batson
Clinical Research Data Warehouse
Architect
Developmental Biology
Lee Niswander, PhD
Professor of Pediatrics and Cell
Biology and Genetics
Section Head, Developmental
Biology
Bruce Appel, PhD
Associate Professor of Pediatrics
Diane G. Wallach Chair in Pediatric
Stem Cell Biology
Director, Pediatric Stem Cell Biology
* Infectious Diseases Faculty
* Epidemiology Faculty
* General Academic Pediatrics
Faculty
**Children’s Outcomes Research
Program Faculty
Intellectual and Developmental
Disabilities Research Center Faculty
+
Nutrition Faculty
+
Clinical Genetics and Metabolism
Faculty
++
TCH Clinical Translational
Research Center Faculty
++
Community Pediatrics Faculty
+
The Children’s Hospital
Sleep Center
John W. Dutton
Research Associate
Clinical Services
Maureen Ishii
Research Coordinator
1997 and has grown to a muiltidisciplinary clinical and
Clinical Trials Organization
Mark J. Abzug, MD*
Professor of Pediatrics
Medical Director, Clinical
Trials Organization
Elizabeth A. Esterl, RN, MS, CCRC
Clinical Director, Clinical Trials
Organization
Children’s Outcome
Research Program
Allison Kempe, MD, MPH*
Associate Professor of Pediatrics
Director, Children’s Outcomes
Research Program
Director, Primary Care Research
Fellowship
1 34 D e p a r t m e n t o f P e d i a t r i c s
The Children’s Hospital Sleep Center was founded in
research center. The Center offers a comprehensive evaluation of patients with sleep disorders and recommends
appropriate treatment options so that the patient and
family can establish normal sleep patterns. Our team
assists primary care physicians and subspecialists with
the diagnosis and treatment of infants, children, and
adolescents with sleep problems.
The sleep conditions that are evaluated are divided
into two categories:
Behavioral sleep conditions, including bedtime resis-
n
tance and fears; early morning rising; excessive daytime drowsiness; insomnia; nightmares, nighttime
programs
Dr. Norman Friedman’s research interests include
evaluating the peri-operative morbidity of sleep-disordered breathing in children as well as whether a parent’s
personality profile can predict a child’s continuous positive airway pressure (CPAP) compliance. Dr. Friedman
is a founding member of the Colorado Sleep Society
and served as the treasurer until 2007. He has been
an active member of the American Academy of Sleep
Medicine, where his committee responsibilities included
the International Affairs and Clinical Practice Review
Committee. Dr. Ann Halbower is nationally recognized
The Children’s Hospital Sleep Center Front row, l - r: Norman
Friedman, Carole Kline, Joyce Martinez, Wendy Walmsley; Back row,
l - r: Willy Boucharel, Christopher Martin, Ann Halbower, Kathy Simar
for her research and clinical work in pediatric sleep disorders. Her current study, funded by the NIH, investigates the impact of childhood sleep-disordered breathing
awakenings, night terrors, and sleep walking; move-
on learning, memory, and neuronal brain injury. She is
ment disorders; seizure disorders; and obesity.
initiating a Children’s Hospital community-based out-
Medical sleep conditions, including apparent-life-
n
reach program for the prevention of sudden unexpected
threatening event (ALTE); chronic lung disease; circa-
death in infants. She is also teaming up with obesity pre-
dian rhythm disorder; daytime sleepiness; narcolepsy;
vention teams at TCH and UCD to determine the risk
restless sleep; rhythmic movement disorder; sleep
of the combined problems of obesity and sleep apnea
apnea and snoring; movement disorders; seizure dis-
and the effects of treatment. Dr. Halbower is the Vice
orders; and obesity.
Chair of the Health Policy Committee at the American
Thoracic Society, which strives to change legislation to
The Children’s Hospital Sleep Center is jointly
administered by the Sections of Pulmonology and
improve sleep and respiratory disorders.
Otolaryngology and works in close collaboration
Education
with the Sections of Child Neurology and Adolescent
The TCH Sleep Center is the pediatric site for the com-
Medicine. The program includes physicians, nurses, psy-
bined UCD and National Jewish Health accredited sleep
chologists, and respiratory therapists with experience in
medicine fellowship. Dr. Ann Halbower directs the pedi-
noninvasive ventilation.
atric training component of the program. Trainees include
physicians in adult and pediatric pulmonology and critical
Research
care medicine, neurologists, psychologists, and visiting
The Children’s Hospital Sleep Center also houses the
international physicians. The training includes clinical vis-
Pediatric Sleep Research Program, directed by Dr. Ann
its with patients and their families, including management
Halbower. Funded by the NIH, Dr. Halbower and
and follow up of sleep patients, polysomnogram interpre-
others are studying the neurophyschological and brain
tation, lectures, and didactic teleconferences with national
neuronal changes associated with childhood sleep apnea.
sleep programs, and includes the adults sleep clinics at
This research endeavor will help determine if treat-
National Jewish Health. Our trainees attend the clinical
ment of obstructive sleep apnea in children reverses the
fellowship for one year, but possible additional years with
abnormal consequences in learning, memory, and brain
a research and publication goal are negotiable. Pediatric
neuronal function.
residents also rotate through the TCH Sleep Center.
2006-2008 Departmental Report
135
programs
The Children’s Hospital Sleep Center Faculty
Faculty
Norman Friedman, MD
Associate Professor of
Otolaryngology and Pediatrics
Director, The Children’s Hospital
Sleep Center
Keith L. Cavanaugh, MD*
Assistant Professor of Pediatrics
Associate Director, The Children’s
Hospital Sleep Center
Ann Halbower, MD*
Associate Professor of Pediatrics
Terry F. Katz, PhD++•
Instructor of Pediatrics
Carole E. Kline, MSN, CPNP*
Senior Instructor of Pediatrics
Clinical Staff
Melody Allen
Ruth Arthur-Asmah
Crystal Beckel, RRT, RPSGT
Susan Crane, PhD
Esther Delatorre-Maes, CRT
Kevin Denton, RRT
Michelle Fiest, RRT
Tiffany Garcia, RT
Gilbert Hinjosa, RT
Robert Kapsner, RRT
Linda Kirkegaard, RRT
Lisa Peterson, CRT, RPSGT
Kathy Simar, RRT, RPSGT
Kelly Sheffield
Deni Smith, RRT
Belinda Tessean
Administrative Staff
Willy Boucharel, MS, DABNM
Manager
Joyce Martinez
Nancy Hake
* Pulmonology Faculty
++
JFK Partners Faculty
• Developmental and Behavioral
Pediatrics Faculty
Kids playing in Boettcher Atrium, The Children’s Hospital
1 36 D e p a r t m e n t o f P e d i a t r i c s
affiliates
The Barbara Davis Center
for Childhood Diabetes
Clinical Services
The Barbara Davis Center for Childhood Diabetes
(BDC) provides care to the majority of children with
diabetes in the State of Colorado and Rocky Mountain
Region, as well as consultation for children throughout
the U.S. Some of the pediatric faculty at the BDC are
also members of the Department of Pediatrics Section
of Endocrinology and provide inpatient diabetes care at
The Children’s Hospital. The BDC combines research
into the immunopathogenesis, prevention, and treatment
of type 1 (insulin-dependent) diabetes mellitus with a
state-of-the-art clinical program that brings to its patients
clinical care aimed at both normalizing their daily lives
and preventing long-term complications of diabetes.
Comprehensive clinical care and continuing patient
and family education are key components in the clinical
program. Newly diagnosed patients and their families
are given intensive and comprehensive individual training, care, and counseling on a day-to-day basis from
clinical care team members, in addition to classes with
other new-onset patients and families. All newly diagnosed
patients and their families receive a copy of the “Pink
Panther” – First Book for Understanding Diabetes –
written by one of our clinicians, Dr. H. Peter Chase.
Providers remain available 24 hours a day, 7 days a
week for changes in regimens, emergencies, and illnesses.
All patients are routinely seen on a quarterly basis, and
with each visit an opportunity for further patient education and family consultation is provided. Comprehensive
care includes nutritional counseling, individual and
family-centered opportunities for psychosocial counseling, periodic cardiovascular and kidney assessment, and
routine eye exams by a diabetes specialist at the Center’s
Eye Clinic. In addition, all patients and their relatives
are offered the opportunity to participate in clinical
and research studies. Patient education continues with
opportunities for participation in local support groups,
special outings and parties arranged by the Guild of
the Children’s Diabetes Foundation, and attendance
at annual summer camps sponsored by the Colorado
American Diabetes Association. The BDC also offers a
number of special one-day courses each year, including
the College Workshop and Grandparents Workshop.
Research
Research into the immunopathogenesis of type 1 diabetes spans both basic and clinical research, with major
emphasis on genetic animal models of type 1 diabetes
and on type 1 diabetes of humans. The Barbara Davis
Center’s faculty has pioneered islet biochemistry, immunobiology of islet beta cell transplantation, identification
of individuals at risk for developing type 1 diabetes, and
trials for the prevention of diabetes and its complications. Locally, the Center initiated DAISY (Diabetes
Autoimmunity Study in the Young), which screened and
genotyped newborns and their families in the Denver
area and continues to follow subjects for antibody
positivity and development of type 1 diabetes. With the
screening of more than 30,000 newborns for genetic risk
of type 1 diabetes at birth, the first study addressing the
development of autoimmunity in children from the general population continues to publish new findings in collaboration with the Colorado School of Public Health.
The BDC also follows the largest, longest standing
national cohort of twins with diabetes in the U.S., with
the BDC Twin Family Study.
The research division is home to the Diabetes and
Endocrine Research Center, an NIH-funded program
that facilitates diabetes research by providing biomedical
core facilities, pilot and feasibility grants, and education
and training programs for faculty, research fellows, graduate and undergraduate students. The NIDDK-supported
Diabetes Endocrinology Research Centers (DERCs) and
Diabetes Research and Training Centers (DRTCs) are
part of an integrated program of diabetes and related
endocrinology and metabolism research. Centers provide
increased, cost-effective collaboration among multidisciplinary groups of investigators at institutions with an
established, comprehensive research base in diabetes and
related areas of endocrinology and metabolism.
2006-2008 Departmental Report
137
affiliates
Barbara Davis Center for Childhood Diabetes Front row, l - r: Rosanna Fiallo-Scharer, Suparna Sarkar, Janet Snell-Bergeon,
Georgeanna Klingensmith, George Eisenbarth, John Hutton; Middle row, l - r: R. Paul Wadwa, Carolyn Banion, Cathy Mowry, Cynthia Cain,
Danny Zipris, Satish Garg; Back row, l - r: Brian Bucca, Dirk Homann, Howard Davidson, David Maahs, Roberto Gianani
Internationally, the BDC is one of six centers world-
Other international programs with which BDC
wide participating in TEDDY (The Environmental
researchers are affiliated include T1DGC (Type 1
Determinants of Diabetes in the Young), one of whose
Diabetes Genetics Consortium), the Brehm Coalition,
founders and principal investigators is our Clinical
the ITN (Immune Tolerance Network, which includes
Director, Dr. Marian Rewers. Additionally, clini-
several intervention studies), the NIH, the Juvenile
cian researchers at the BDC, including our Executive
Diabetes Foundation Autoimmunity Prevention
Director, Dr. George Eisenbarth, were seminal players
Centers, and the CACTI Study (Cardiovascular and
in the development of TrialNet, a network of 18 clini-
Arteriosclerosis Complications in the Young). For a list
cal centers working in cooperation with screening sites
of affiliated studies and requirements for participation
throughout the U.S., Canada, Finland, United Kingdom,
see the Center’s Web site for clinical studies:
Italy, Germany, Australia, and New Zealand. This net-
www.uchsc.edu/misc/diabetes/clinresearch.html.
work is dedicated to the study, prevention, and early
The Center’s research division has been designated
treatment of type 1 diabetes and includes the Natural
a Juvenile Diabetes Research Foundation (JDRF) BDC
History Study and several intervention studies under the
Autoimmune Prevention Center (APC), an international
direction of Dr. Peter Gottlieb in the Adult Clinic. A
collaborative research network of five centers world-
Stem Cell Endowment Fund for the BDC was initiated
wide. The APC supports translational diabetes research
in 2008, with funding to be partially matched by the
and provides additional core facilities for access to
Gates Frontiers Fund, a $6 million regenerative medicine
human clinical material, immunoassay and lymphocyte
and stem cell initiative created by the Charles C. Gates
phenotyping. Research faculty investigators at the BDC
family for programs at the Anschutz Medical Campus.
were the first to clone T cells causing type 1 diabetes.
1 38 D e p a r t m e n t o f P e d i a t r i c s
affiliates
T cells play a major role in autoimmunity, both in its
tigation of autoimmunity in the NOD mouse model of
development and in its regulation. A key focus in research
type 1 diabetes, including anti-insulin autoantibodies
at the BDC has been the role the immune system plays
and anti-insulin islet-infiltrating T cells that have a shared
in the development of diabetes and in the discovery of
T cell receptor Alpha chain motif. Dr. Pamela Fain’s
key islet cell antigens that the immune system attacks to
research focuses on the genetics of type 1 diabetes
destroy functioning Гџ cells, which produce insulin. Two
and vitiligo and their association with other autoim-
major antigens were discovered by BDC researchers in
mune diseases, with a special interest in the population
the laboratory of its Director of Research, one as recently
genetics of the HLA system. Specific projects include
as the fall of 2007: ZnT8, the zinc transporter.
genome-wide association studies of vitiligo and twin
The BDC also works with pharmaceutical companies
studies of type 1 diabetes. Dr. Rosanna Fiallo-Scharer’s
to test new insulins, new insulin delivery systems, and
interests include research in continuous glucose monitor-
state-of-the-art glucose sensing systems, including the
ing (CGM) in children with type 1 diabetes. Dr. Satish
new continuous glucose monitoring (CGM) devices.
Garg and his research team are very active with several
The BDC continues to be actively involved in efforts to
clinical research studies that include investigating con-
increase insurance coverage for insulin pumps, CGMs,
tinuous glucose monitoring systems, newer insulins,
and other new technologies associated with improve-
and alternative modes of insulin administration. Dr.
ment in diabetes care and outcomes. Research is under
Peter Gottlieb and his research staff are working on
way to “close the loop” with continuous glucose moni-
projects in new onset type 1 diabetes subjects. One of
tors enabled to stop insulin delivery in pumps to reverse
the research models is looking at how new medications
nocturnal hypoglycemia.
could suppress/modulate the immune system to poten-
A more detailed summary of research at the Center
tially slow or alter the progression of type 1 diabetes.
can be obtained by consulting the Barbara Davis
Dr. Dirk Homann’s research interests lie in the areas
Center’s Web site at www.barbaradaviscenter.org.
of autoimmunity, immunological memory, and persis-
Dr. Jennifer Barker’s research interests include the
tent viral infections. The common theme among these
prediction and prevention of type 1 diabetes and its
topics is a focus on T cell immunity under conditions
associated autoimmune disease. Dr. H. Peter Chase’s
where specific T cells may cause pathology (autoim-
research interests are in continuous glucose monitor-
munity), provide protection upon reencounter with a
ing (CGM) in children with type 1 diabetes. He is also
pathogen (immunological memory), or are impaired in
working on the “closed-loop (CGM  Insulin Pump)
their capacity to control an infection (persistent virus
pancreas.” He is a co-principal investigator in the
infections). Dr. John Hutton’s research focuses on the
Type 1 Diabetes/TrialNet diabetes prevention study.
molecular cell biology of insulin secretion and the role
Dr. George Eisenbarth’s research interests include under-
of secretory granule proteins in the pathogenesis of type
standing the basic immunology underlying the patho-
1 and 2 diabetes. Current studies include the roles of the
genesis of type 1 diabetes, specifically the MHC (Major
newly discovered zinc transporter, SLC30A8, the newly
HistoCompatibility) peptides-T cell interactions that
discovered type 1 diabetes autoantigen, ZnT8, a pancre-
lead to disease. He is interested in studying the patho-
atic beta cell-specific zinc transporter, and islet glucose
genesis, prediction, and prevention of type 1 diabetes
6 phosphatase G6PC2 as autoantigens in type 1 diabetes
mellitus, including studies of the immunogenetics of type
and the development of novel antigen-based therapeutic
1 diabetes, focusing on the activation and natural his-
approaches to the prevention of the disease. His lab also
tory of specific patterns of autoimmunity in genetically
studies the cellular biology of the beta cell and the role
susceptible individuals. His basic studies include inves-
of the SLC30A8 in the transport of cellular zinc and the
2006-2008 Departmental Report
139
affiliates
secretion of insulin, and the functional divergence, if
diabetes and their prevention, with special emphasis on
any, of a tryptophan to arginine single nucleotide poly-
cardiovascular and renal complications. Dr. Wadwa
morphism in the carboxyl terminus of ZnT8 shown to
also directs the Barbara Davis Center’s state-wide health
confer susceptibility to type 2 diabetes Dr. Hutton is the
care program on the early detection, prevention, and risk
Director of the UCD Diabetes and Endocrine Research
management of cardiovascular disease in type 1 diabe-
Center (DERC) and the BDC JDRF Autoimmunity
tes. Dr. Phillippe Walraven’s research interests include
Prevention Center. Dr. Georgeanna Klingensmith is
research in continuous glucose monitoring (CGM) in
studying the chronic complications of diabetes and their
children with type 1 diabetes and the prediction and
prevention. She also heads the fellowship program at
prevention of type 1 diabetes. Dr. Danny Zipris’ research
the Barbara Davis Center, which seeks to mentor and
interests include understanding the mechanisms by which
develop young scientists to pursue careers in diabetes
virus infection triggers autoimmune diabetes in rat mod-
research. Dr. David Maahs is studying the complications
els of the disease. Another major interest is identifying
of diabetes and their prevention, especially cardiovas-
the role of the innate immune system and TLR (Toll-Like
cular and renal complications. Dr. Ramachandra Naik
Receptor) signaling pathways in the course of diabetes in
is a clinical researcher, involved in several studies with
genetically susceptible individuals and animal models.
Dr. Garg, which include investigating continuous glucose monitoring systems, newer insulins, and alternative
Education
modes of insulin administration. Dr. Marian Rewers’
The Barbara Davis Center is committed to training, edu-
primary research has been in the area of epidemiology/
cating, and mentoring our predoctoral and postdoctoral
etiology of type 1 diabetes as well as insulin resistance
research fellows to become the next generation of out-
and cardiovascular complications of both type 1 and 2
standing type 1 diabetes researchers in a wide range of
diabetes. Dr. Rewers is the principal investigator of four
disciplines, including immunology, biochemistry, cellular
large NIH-funded projects: the Diabetes Autoimmunity
and molecular biology, and population genetics.
Study in the Young (DAISY), The Environmental
The BDC has a strong commitment to educating and
Determinants of Diabetes in the Young (TEDDY), the
training future pediatricians. Our faculty teaches and
Coronary Artery Calcification in Type 1 Study (CACTI),
mentors fellows, residents, and medical students while
and the Genetic and Environmental Causes of Celiac
providing specialized learning opportunities in the care
Disease. Dr. Suparna Sarkar’s research interests are in
and prevention of and ongoing search for a cure for type
beta cell neogenesis, regeneration and death. Dr. Robert
1 diabetes. Medical students rotate through the BDC
Slover’s primary focus is in research leading to the
on elective half-day rotations. Endocrine fellows, along
development of a “mechanical pancreas.” This clinical
with students from the Child Health Associate/Physician
research area includes the use of continuous glucose
Assistant Program also rotate through the Center.
monitors, insulin pump delivery systems, and the devel-
A national conference, Practical Ways to Achieve
opment of algorithms that allow a “closed loop system”
Targets in Diabetes Care, for health professionals is held
for the management of diabetes. Dr. Andrea Steck’s
every two years in Keystone, Colorado. This course is
research interests are in the area of the genetic etiology
designed to help health care providers caring for adoles-
of autoimmunity and type 1 diabetes. Dr. Janet Wenzlau
cents and adults with diabetes, including but not limited
focuses on the analysis of humoral autoimmune respons-
to, internists, pediatricians, family physicians, physician
es in T1D. Her projects include epitope identification,
assistants, nurse practitioners, nurses, and certified
assay development, and mechanisms of disease progres-
diabetes educators.
sion. Dr. R. Paul Wadwa studies the complications of
1 40 D e p a r t m e n t o f P e d i a t r i c s
affiliates
Highlights
George Eisenbarth received the Banting Medal for
Scientific Achievement at the American Diabetes
Association’s 69th Annual Scientific Sessions. This
award for scientific excellence recognizes significant,
long-term contributions to the understanding, treatment, or prevention of diabetes and is the highest
honor world-wide in the field!
Barbara Davis Center for Childhood Diabetes Faculty
Faculty
George S. Eisenbarth, MD, PhD
Professor of Pediatrics, Medicine
and Immunology
Executive Director, Barbara Davis
Center for Childhood Diabetes
Eisenbarth Barbara Davis Center
Endowed Chair
Carolyn Banion, RN, NP
Senior Instructor of Pediatrics
Jennifer M. Barker, MD••
Assistant Professor of Pediatrics
Christie Beatson, BARD, CDE
Instructor of Pediatrics
Brian Bucca, OD, FAAO
Instructor of Pediatrics
Head, Ophthalmology Clinic
Cynthia Cain, RN, NP
Instructor of Pediatrics
H. Peter Chase, MD
Professor of Pediatrics
Howard W. Davidson, BSc, PhD
Assistant Professor of Medicine
Pamela R. Fain, PhD
Associate Professor of Medicine
and Pediatrics
Rosanna V. Fiallo-Scharer, MD••
Assistant Professor of Pediatrics
Satish K. Garg, MD
Professor of Pediatrics and Medicine
Chief, Adult Diabetes Clinic
Satish K. Garg and Kavita Garg
Barbara Davis Center Adult
Diabetes Clinical Research
Professorship
Satish K. Garg and Bimla Garg
Barbara Davis Center Adult Clinic
Endowed Chair
Roberto Gianani, MD
Assistant Professor of Pathology
Peter A. Gottlieb, MD
Associate Professor of Pediatrics
and Medicine
Director, Translational Research Unit
Susie Owen, RN
Senior Instructor of Pediatrics
Biagio A. Pietra, MD•
Associate Professor of Pediatrics
Marian J. Rewers, MD, PhD, MPH••
Professor of Pediatrics
Professor of Epidemiology,
Colorado School of Public Health
Clinical Director
Suparna Sarkar, MBBS, PhD
Instructor of Pediatrics
Dana Shepard, LCSW
Instructor of Pediatrics
Robert H. Slover II, MD••
Associate Professor of Pediatrics
Erin Smith, RN
Instructor of Pediatrics
Raymond S. Gutin, MD
Senior Instructor of Pediatrics
Kathy Smith, BSN
Instructor of Pediatrics
Kathryn Haskins, PhD
Professor of Immunology
Andrea Steck, MD
Instructor of Pediatrics
Dirk Homann, MD, PhD
Assistant Professor of Pediatrics
and Immunology
Graciela Tellez, RN
Instructor of Pediatrics
Sandra L. Hoops, MS, CHA/PA-C••
Associate Professor of Pediatrics
John C. Hutton, PhD
Professor of Pediatrics and
Cellular and Structural Biology
Research Director
Evangeline Johnson, RD, CDE
Instructor of Pediatrics
Georgeanna J. Klingensmith, MD••
Professor of Pediatrics
Head, Pediatric Clinic
Libbie Tuthill, BSN
Instructor of Pediatrics
Mary Voelmle, NP
Instructor of Pediatrics
R. Paul Wadwa, MD••
Assistant Professor of Pediatrics
Philippe A. Walravens, MD••
Professor of Pediatrics
Laurie Weiner, RN, CDE
Instructor of Pediatrics
Georgia Koch, RN
Senior Instructor of Pediatrics
Philippe Weintraub, MD
Associate Professor of Pediatrics
and Psychiatry
Edwin Liu, MD••
Assistant Professor of Pediatrics
Janet M. Wenzlau, PhD
Instructor of Pediatrics
Benita Lopez-Baca, BSN
Instructor of Pediatrics
Alexander C. Wiseman, MD
Assistant Professor of Medicine,
Division of Renal Diseases
and Hypertension
Kathryn Love, RD, LD/N
Instructor of Pediatrics
David Maahs, MD
Assistant Professor of Pediatrics
Lisa Meyers, BAMS
Instructor of Pediatrics
Cathy Mowry, RN, NP
Senior Instructor of Pediatrics
Ramachandra Naik, MD
Assistant Professor of Pediatrics
Sophie Youtz, RN
Instructor of Pediatrics
Philip S. Zeitler, MD, PhD++••
Professor of Pediatrics
Medical Director, TCH Clinical
Translational Research Center
Research Associates
Sunanda Babu, PhD
Marilyne G. Coulombe, PhD
Kimberly McFann, PhD
Dong Mei Miao, MD
Liping Yu, MD
Fellows
2005-2006
Theresa Aly, MD
Naru Babaya, MD, PhD
Elise Eller, PhD
Mohamed Jahrami, PhD
Kristine Juhl, PhD
Toni Kim, MD
Chris Kishiyama, MD
Masakazu Kobayashi, PhD
Sune Kobberup, PhD
Tinalyn Kupfer, PhD
Megan Moriety, MD
Maki Nakayama, MD
Pia Nyeng, PhD
Hanjun Quin, MD, PhD
Jill Simmons, MD
Jian Wang, MD
Jee Suk Yu, PhD
Li Zhang, MD, PhD
2006-2007
Theresa Aly, MD
Elise Eller, PhD
Kim Fowler, PhD
Mohamed Jahrami, PhD
Toni Kim, MD
Chris Kishiyama, MD
Masakazu Kobayashi, PhD
Sune Kobberup, PhD
Tinalyn Kupfer, PhD
Megan Moriety, MD
Maki Nakayama, MD
Pia Nyeng, PhD
Hanjun Quin, MD, PhD
Rangasamy Sampathkumar, PhD
Li Zhang, MD, PhD
2007-2008
Jen Eberlien, MSc
Kim Fowler, PhD
Toni Kim, MD
Masakazu Kobayashi, PhD
Sune Kobberup, PhD
Megan Moriety, MD
Maki Nakayama, MD
Pierre Pirot, PhD
Rangasamy Sampathkumar, PhD
Leah Sheridan, PhD
Li Zhang, MD, PhD
Danny Zipris, PhD
Assistant Professor of Pediatrics
Mark R. Nicolls, MD
Assistant Professor of Medicine
2006-2008 Departmental Report
141
affiliates
2008-2009
Jen Eberlien, MSc
Naru Babaya, MD, PhD
Kim Fowler, PhD
Jean Jasinski, PhD
Maki Nakayama, MD
Aaron Michels, MD
Leah Sheridan, PhD
Pierre Pirot, PhD
Li Zhang, MD, PhD
Diabetes Educators
Deanna Abernathy, RN
Christie Beatson, RD, CDE
Cindy Cain, RN, NP, CDE
Ellen Fay-Itzkowitz, LCSW
Jennifer Fischer, RN, ND
Angel Johnson, RD, CDE
DeAnn Johnson, RN, BSN, CDE
Georgia Koch, RN, BSN
Benita Lopez-Baca, RN, CDE
Kathryn Love, MS, RD
Kelly McCracken, RD
Lisa Meyer, MS
Gail Neuenkirchen, NP
Catherine Olinger, RN
Darcy Owen, MS, RD, CDE
Susie Owen, RN, CDE
Dana Shepard, LCSW
Erin Smith, RN, BSN
Kathy Smith, RN
Gail Spiegel, MS, RD, CDE
Graciela Tellez, RN
Rita Temple-Trujillo, LCSW, CDE
Libbie Tuthill, RN, CDE
Laurie Weiner, RN, CDE
services are provided at hospital-based clinics. Pediatric
++
is an innovative program that provides clinical services at
TCH Clinical Translational
Research Center Faculty
• Cardiology Faculty
•• Gastroenterology, Hepatology
and Nutrition Faculty
•• Endocrinology Faculty
•• Child Health Associate/Physician
Assistant Program Faculty
specialty care includes neurology, allergy and immunology, and cardiology and surgical clinics staffed by faculty
from the Department of Pediatrics. In 2008, there were
more than 90,000 patient visits for ambulatory, urgent
or emergent pediatric and adolescent services, and the
inpatient pediatric ward and intensive care unit admitted
1,700 children and adolescents for medical, surgical, and
psychiatric care. The Denver School-Based Clinic Program
12 elementary, middle, and high schools. Approximately
7,000 children and adolescents receive care each year.
Research
The faculty conducts clinical research that is directed
at common problems identified during the delivery of
Denver Health
primary care to an urban pediatric population. These
projects are often collaborative efforts to ensure service
Clinical Services
delivery by overcoming the inherent barriers to care in
Denver Health was founded 148 years ago with a mis-
an underserved population.
sion to serve the emergent needs of the general popula-
Dr. Steven Federico has studied barriers to the access of
tion as well as the needs of special and vulnerable popu-
primary care and interventions to overcome these barriers.
lations, such as the poor, victims of violence, and the
Dr. Simon Hambidge has studied vaccine safety and strat-
homeless. To meet these needs, Denver Health integrates
egies to increase childhood immunization and well-child
acute hospital and emergency care with public health
care. Dr. Patricia Braun studies outpatient management of
and community health clinics to deliver primary, preven-
common viral infections and incorporating dental screen-
tive, and acute care services.
ing into pediatric well-child care. Dr. Mark Anderson has
Denver Health consists of a 477-bed acute care
investigated acute management of childhood asthma and
hospital, 8 family health centers located throughout
the relationship between asthma and exposure to environ-
metropolitan Denver, the public health department,
mental tobacco smoke. Dr. Mary O’Connor has designed
12 school-based clinics, the 911 emergency ambulance
a curriculum to teach health care professionals the essen-
and paramedic service, the Rocky Mountain Poison
tials of breastfeeding. Her curriculum can be accessed at
and Drug Center, and the Rocky Mountain Regional
www.breastfeedingbasics.org.
Trauma Center. In 2008, the Denver Emergency Center
for Children opened at Denver Health.
In 2008, approximately 3,700 newborns were deliv-
Education
Denver Health is committed to training the next genera-
ered and received routine newborn care or were admit-
tion of clinicians in this unique, integrated health care
ted to the newborn intensive care unit. Acute, primary,
delivery system. Pediatric residents in training spend
and preventive services are provided to children and
one third of their time at Denver Health, seeing children
adolescents at the 8 clinics located throughout the city.
in primary care clinics, the Emergency Department, the
Urgent, emergency, and some specialized pediatric
pediatric wards, intensive care, and the nursery and
1 42 D e p a r t m e n t o f P e d i a t r i c s
affiliates
Denver Health Front row, l - r: Kristine Knuti, Claudia Kunrath, Cherie Spinks, Tara Edick, Trang Le-MacKenzie, Barbara Burrowes,
Janine Solano; Middle row, l - r: Sharon Langendoerfer, Peggy Baikie, Eileen Figaro, Margaret Catchpole, Meegan Leve, Laura Monthathong,
Megan Henderson, Kathryn Love-Osborne; Back row, l - r: Stephen Kudebeh, Laura Hix, Gregory Miranda, Nancy Riordan-Kunzie, Jerry Baros,
Jan Johnson, Lora Melnicoe
Denver Health Faculty
neonatal intensive care unit. They work closely with
faculty in a community-based pediatrics training that
emphasizes care to the underserved. Medical students
and physician assistant students also train in patient care
in these areas.
Highlights
Simon Hambidge received a National Scholars Award
n
from the Robert Wood Johnson Foundation and the
Charles C. Shepard Science Award from the CDC
Office of the Director.
Paritosh Kaul received a Proclamation, In Salute
n
of Paritosh Kaul, MD, for Service to Adolescent
Medicine, City and County of Denver, Proclamation
20 Series of 2007.
Paul Melinkovich is President-Elect of the Board
n
of Directors, National Assembly on School-Based
Health Care and was President of the Denver Health
Medical Staff.
Faculty
John W. Ogle, MD*
Professor of Pediatrics
Director of Pediatrics, Denver Health
Vice Chair, Affiliate Denver Health
Mark E. Anderson, MD*
Associate Professor of Pediatrics
Patricia A. Braun, MD*
Associate Professor of Pediatrics
Jeffrey M. Brown, MD, MPH**
Professor of Pediatrics
Betsey M. Chambers, MD*
Instructor of Pediatrics
William H. Edwards, MD*
Instructor of Pediatrics
Rachel A. Estorge, MD*
Instructor of Pediatrics
Steven G. Federico, MD*
Assistant Professor of Pediatrics
Simon J. Hambidge, MD, PhD***
Associate Professor of Pediatrics
Director, Community Health
Pediatrics
Megan G. Henderson, MD*
Instructor of Pediatrics
Luz M. Jimenez, MD*
Instructor of Pediatrics
Paritosh Kaul, MD*++
Associate Professor of Pediatrics
Kristine A. Knuti, MD*
Instructor of Pediatrics
Claudia B. Kunrath, MD••
Assistant Professor of Pediatrics
Sharon I. Langendoerfer, MD*
Associate Professor of Pediatrics
Kathryn A. Love-Osborne, MD*++
Associate Professor of Pediatrics
Chanda C. McDaniel, MD*
Instructor of Pediatrics and
Internal Medicine
Catherine L. McIlhany, MD*
Instructor of Pediatrics
Paul Melinkovich, MD*
Professor of Pediatrics and
Preventive Medicine
Lora H. Melnicoe, MD, MPH*
Senior Instructor of Pediatrics
Gregory Q. Miranda, MD*
Instructor of Pediatrics
2006-2008 Departmental Report
143
affiliates
Denver Health Front row, l - r: Sonja O’Leary, Carol Okada, Betsey Chambers, Lisa Kelly, Kathleen Henderson, Kellie Monahan;
Middle row, l - r: Lisa Abrams, Wanda Marshall, Heather Varnell, Connie Johnson, Kimberly Huebner, Thia Gonzales, Mary O’Connor;
Back row, l - r: Patricia Braun, Della Lane, Simon Hambidge, Janine Young, Stephen Vogler
Mary E. O’Connor, MD, MPH*
Associate Professor of Pediatrics
Carol R. Okada, MD*•
Instructor of Pediatrics
Associate Program Director,
Pediatric Residency Program
Elaine N. Scholes, MD*
Professor of Pediatrics
Heather G. Varnell, MD*
Instructor of Pediatrics
Stephen D. Vogler, MD*
Instructor of Pediatrics
Kathryn M. Wells, MD, FAAP*+
Assistant Professor of Pediatrics
James J. Woods, DO*
Senior Instructor of Pediatrics
Janine Young, MD*
Assistant Professor of Pediatrics
Clinical Faculty
Laura Q. Adamowski, PA-C
Assistant Clinical Professor
of Pediatrics
Jerry J. Baros, MD*
Clinical Professor of Pediatrics
John Kozlevchar, CHA/PA-C*
Assistant Clinical Professor
of Pediatrics
Stephen Kudebeh, CHA/PA-C*
Assistant Clinical Professor
of Pediatrics
Sandra Kuester, PA-C
Assistant Clinical Professor
of Pediatrics
Jody Maes, MD*
Clinical Professor of Pediatrics
Sonja O’Leary, MD*
Clinical Instructor of Pediatrics
1 44 D e p a r t m e n t o f P e d i a t r i c s
Lilliam Samour, PA-C
Assistant Clinical Professor
of Pediatrics
Janine Solano, MS, PA-C*
Associate Clinical Professor
of Pediatrics
Cherie Spinks, CHA/PA-C*
Clinical Instructor of Pediatrics
Clinical Staff
Pamela Brewster, PA-C
Carol Charney, FNP
Laura Hix, PA-C
Jan Johnson, PNP
Sherry Johnson, PA-C
Trang Le-MacKenzie, PA-C
* Neonatology Faculty
* Infectious Diseases Faculty
* Pediatric Hospital Medicine
Faculty
* General Academic Pediatrics
Faculty
**Children’s Outcomes Research
Program Faculty
Kempe Children’s Center Faculty
++
Adolescent Medicine Faculty
• Medical Education Faculty
•• Critical Care Medicine Faculty
+
affiliates
National Jewish Health
Clinical Services
The pediatric program at National Jewish Health –
NJ4kids – provides a continuum of care from outpatient
to inpatient services, with a major emphasis on asthma
and other allergic diseases (atopic dermatitis, allergic
rhinosinusitis, food allergy, and eosinophilic gastrointestinal disorders), immune system disorders and recurrent
infections, pulmonary disorders, rheumatological disorders, and behavioral health issues.
A major focus has been the integration of care in the
areas of allergy, asthma, immunology, and rheumatology at National Jewish and TCH. National Jewish
faculty members have weekly clinics in allergy, asthma,
sinusitis, and eosinophilic gastrointestinal diseases at
National Jewish Health Front row, l - r: Stanley Szefler, Ronina Covar,
Pia Hauk, Erwin Gelfand; Back row, l - r: David Nichols, Carl White,
Mark Boguniewicz, F. Dan Atkins, David Fleischer
TCH. These programs have brought together teams of
specialists and support staff to enhance clinical care and
intervention in the atopic march. Dr. Ronina Covar
teaching programs for patients and housestaff. National
and Dr. Joseph Spahn have been identifying the links
Jewish faculty also staff clinics at Denver Health as well
between the origins of asthma and asthma progression.
as a number of satellite clinics.
Dr. Azzeddine Dakhama’s research explores the role
of respiratory syncytial virus in post-bronchiolitis
Research
wheezing and asthma and the role of neuropeptides
National Jewish and TCH faculty members participate
in airway inflammation and hyperresponsiveness.
in both clinical and basic research programs. Despite
Dr. David Fleischer is conducting studies in food allergy.
the current funding climate, the number of grants has
Dr. Erwin Gelfand’s primary research interests center on
increased from the NIH, the EPA, other federal agencies,
allergic airway inflammation and immunodeficiency.
and the pharmaceutical industry. Faculty members have
Dr. Pia Hauk is defining the contributions of bacterial
played major roles in NIH-funded multicenter studies
cell products to asthma. Dr. Richard Johnston, Jr.,
evaluating asthma and eczema therapies. The major pro-
researches the cell biology of phagocytic cells and immu-
grams in asthma, inflammation, signal transduction, and
nodeficiency disease. Dr. Donald Leung investigates the
psychosocial problems in chronic illness have been very
immune mechanisms of allergic diseases, particularly
successful at National Jewish. For eleven consecutive
atopic dermatitis and severe asthma. Dr. Andrew Liu is
years, National Jewish has been ranked the #1 respiratory
studying allergy and asthma development and preven-
hospital in America by U.S. News & World Report.
tion, hygiene theory, and gene-environment interactions.
Faculty are active in a wide range of research areas.
Dr. Henry Milgrom’s research interests involve the
Dr. F. Dan Atkins’ primary interest is in food allergies
therapy of asthma and patient adherence to therapy.
and gastrointestinal eosinophilic disorders. Dr. Donna
Dr. David Nichols is studying lung allergic inflammation
Bratton is investigating the interactions between lipid
and cystic fibrosis. Dr. Nathan Rabinovitch’s research is
mediators and eosinophil and neutrophil survival and
in environmental triggers of asthma. Dr. Stanley Szefler
trafficking. Dr. Mark Boguniewicz researches atopic
is interested in the pharmacotherapy of childhood
dermatitis and immunomodulatory therapy and early
asthma, especially understanding variability in response
2006-2008 Departmental Report
145
affiliates
to treatment. Dr. Carl White is researching lung development and the effects of extremes of oxygen, oxidants,
and antioxidants in acute and chronic lung injury.
Education
National Jewish Health and the UCDSOM Department
of Pediatrics offer an ACGME-certified, two-year
fellowship in pediatric allergy and immunology, which
sponsors two to three fellows each year. Training for
pediatric residents takes place in a single, integrated
academic program at National Jewish Health, the
University of Colorado Hospital, the Barbara Davis
Center for Childhood Diabetes, and The Children’s
Hospital. An elective in pediatric allergy and immunology is available for fourth-year medical students who
have successfully completed a pediatric clerkship. Caseby-case teaching is conducted in inpatient clinics, with
four different assignments: Pediatric Day Program and
Medical Officer of the Day at National Jewish; Pediatric
Clinics at The Children’s Hospital; and Adult Allergy
Consult Service at UCD. Teaching also takes place in
our outpatient clinics at National Jewish, TCH, and
UCD: Outpatient Pediatric Allergy and Immunology
Clinic, Adult Allergy Continuity Clinics and Consult
Service, Immunodeficiency Clinic, Dermatology/Atopic
Dermatitis, Rheumatology, and ENT Clinics. We also
use formal teaching conferences.
National Jewish Health Faculty
Faculty
Erwin W. Gelfand, MD**
Professor of Pediatrics
Chairman, Department of Pediatrics,
National Jewish Health
Vice Chair, Affiliate National Jewish
Health
Gary L. Larsen, MD*
Professor of Pediatrics
F. Dan Atkins, MD*++
Associate Professor of Pediatrics
Associate Director, Asthma Program
Henry Milgrom, MD
Professor of Pediatrics
Mark Boguniewicz, MD
Professor of Pediatrics
Donna L. Bratton, MD
Professor of Pediatrics
Endowed Chair, C.L.C. Kramer
Foundation Scientist in Pediatric
Medicine
Susan M. Brugman, MD*
Associate Professor of Pediatrics
Kirstin D. Carel, MD
Assistant Professr of Pediatrics
Ronina A. Covar, MD
Associate Professor of Pediatrics
Donald Y.M. Leung, MD, PhD
Professor of Pediatrics
Andrew H. Liu, MD
Associate Professor of Pediatrics
David P. Nichols, MD
Assistant Professor of Pediatrics
Nathan Rabinovitch, MD
Associate Professor of Pediatrics
Joseph D. Spahn, MD
Associate Professor of Pediatrics
Fellowship Director
Stanley J. Szefler, MD
Professor of Pediatrics
David G. Tinkelman, MD
Professor of Pediatrics
Carl W. White, MD*
Professor of Pediatrics
Azzeddine Dakhama, PhD
Research Associate Professor
of Pediatrics
Affiliated Staff
Allan Bock, MD
Clinical Professor of Pediatrics
David M. Fleischer, MD++
Assistant Professor of Pediatrics
Harold Nelson, MD
Pia Hauk, MD
Instructor of Pediatrics
Richard B. Johnston, Jr., MD
Professor of Pediatrics
Associate Dean for Research
Development, University of
Colorado Denver School of
Medicine
Marzena E. Krawiec, MD*
Associate Professor of Pediatrics
Clinical Fellows
Aideen Byrne, MD (2008-2010)
Heather Cassell, MD (2007-2009)
Joshua Davidson, MD (2007-2009)
Tracy Kruzick, MD (2007-2009)
Jonathan Malka, MD (2008-2010)
Daniel Searing, MD (2008-2010)
Grace Tamesis, MD (2006-2009)
*
Pulmonology Faculty
**Allergy, Immunology and
Rheumatology Faculty
Gastrointestinal Eosinophil
Center Faculty
++
Dr. Matthew Haemer gets examined by his patient
1 46 D e p a r t m e n t o f P e d i a t r i c s
Recognition
2 0 0 6 – 2 0 0 8 DE PA R T M E N TA L R E P O R T
awards and honors
The Interfaith Chapel, The Children’s Hospital
awards and honors
sections
Adolescent Medicine
Karolyn Kabir, MD, received the
Evelyn G. Laufer Award for Best Oral
Research Presentation at the North
American Society for Pediatric and
Adolescent Gynecology (NASPAG)
Conference (2008).
David W. Kaplan, MD, MPH, was
given the Founders of Adolescent
Health Award by the AAP Section
on Adolescent Health (2006);
Visiting Professor, Kolkata Medical
College, Kolkata, India (2006-2007);
Member, American Pediatric Society
(2007); 5280 Magazine’s Top Doctors
in Denver (2005-2008); Best Doctors
in America (1997-2008); Board of
Directors, Society for Adolescent
Medicine (2003-2007); Chairman,
Board of Directors, Center for
Adolescent Health and the Law,
Chapel Hill (2002-2008); Board
Member, Incenter Strategies for
the Advancement of Adolescent
Health (2006); Adolescent Medicine
Vaccine Advisory Board (20042008); Oration Address, Adolescon:
The Annual National Adolescent
Medicine Conference of the Indian
Academy of Pediatrics, Hyderabad,
India (2008); Milton J.E. Senn
Lectureship Award, AAP Council on
School Health (2008).
Daniel H. Reirden, MD, serves
on the Board of Directors of the
Colorado AIDS Project (2007-present); Finalist, Society of Adolescent
Medicine’s New Investigator of the
Year (2008).
Amy E. Sass, MD, MPH, is listed
in 5280 Magazine’s Top Doctors
in Denver (2007-2008); Teaching
Scholar, UCD School of Medicine
(2008-2010); Board Member, Rocky
Mountain Chapter of the Society for
Adolescent Medicine (2004-present).
Jeanelle Sheeder, MSPH, won
the Outstanding PhD Student,
Clinical Sciences Program, UCD
(2008); Innovations Award, Clinical
Sciences Program, UCD (2007);
Best Presentation, Annual Student
Research Forum, UCD (2007).
Eric J. Sigel, MD, is listed in 5280
Magazine’s Top Doctors in Denver
(2003-present); Board Member,
Metro Denver Partners (1996-2008).
Allergy, Immunology
and Rheumatology
Leonard L. Dragone, MD,
PhD, received a J.V. Satterfield
Arthritis Investigator Award from
the Arthritis Foundation for the
highest-ranked Arthritis Investigator
(2007-2009); Outstanding Teacher
of the Year, NJH Pediatric Allergy
and Immunology Fellows (2008);
Outstanding Junior Faculty in
Pediatrics, NJH (2008); Member,
SPR (2008); American College
of Rheumatology Research and
Education Foundation Medical
Student Research Preceptorship, for
mentee Daniel Wells MS2 at UCD
(2007).
J. Roger Hollister, MD, is listed
in 5280 Magazine’s Top Doctors in
Denver (2005-present); Best Doctors
in America (2007).
Jennifer B. Soep, MD, is listed in
5280 Magazine’s Top Doctors in
Denver (2005-present).
Dr. Erwin Gelfand’s awards and
honors are listed under National
Jewish Health.
Cardiology
Eduardo M. da Cruz, MD, is a
Member of the Scientific Advisory
Committee of the Association for
European Paediatric Cardiology
(AEPC) (2004-present); Member,
European Multidisciplinary Joint
Committee for Intensive Care
Medicine (2003-present); Member,
Union EuropГ©enne des MГ©decins
SpГ©cialistes (2003-present);
Member, Accreditation Committee,
European Board of Intensive Care
(2003-present); Founder and
Chairman, Working Group on
Pediatric Cardiac Intensive Care,
AEPC (2004-2010); Member, Board
of Directors, Congenital Committee
(Congenital Domain), European
Association of Cardio-Thoracic
Surgery (2008); Member, Board of
Directors, Surgeons of Hope (2008);
Founding Member, World Society
for Pediatric and Congenital Heart
Surgery (2007-present); Member,
Working Group on Interventional
Catheterization, AEPC (2005-present); Mentor and President,
Recommendations and Guidelines
Committee for Training in Pediatric
1 48 D e p a r t m e n t o f P e d i a t r i c s
Cardiac Intensive Care, APEC
(2005-present); Member, Scientific
and Advisory Review Committee,
TCH Clinical Translational
Research Center, Colorado Clinical
Translational Sciences Institute
(CCTSI) (2008); Member, SPR (2008);
Editor, Handbook of Pediatric
Cardiovascular Drugs (2007);
Editor, Cuidado del Paciente CrГ­tico
Cardiovascular PediГЎtrico [Care
of the Critically-Ill Cardiovascular
Pediatric Patient] (2007); Program
Organizer and Director, Scientific
Session, Working Group on
Paediatric Cardiac Intensive Care:
“Current concepts in the management of low cardiac output
syndrome,” AEPC 41st Annual
Meeting, Basel, Switzerland (2006);
Program Organizer and Director,
Scientific Session, Working Group
on Paediatric Cardiac Intensive
Care: “Common issues in the daily
management of acute pediatric
cardiology patients,” AEPC 42nd
Annual Meeting, Warsaw, Poland
(2007); Program Organizer and
Director: “The Latin Symposium of
Pediatric Cardiac Intensive Care,”
5th World Congress on Pediatric
Critical Care, Geneva, Switzerland
(2007); Program Organizer and
Director (with Duncan Macrae): “PreCongress Post-Graduate Course on
Pediatric Cardiac Intensive Care,”
5th World Congress on Pediatric
Critical Care, Geneva, Switzerland
(2007); Program Organizer and
Director: “Update on Pediatric
Cardiac Intensive Care,” AEPC 43rd
Annual Meeting, Venice, Italy (2008);
Program Organizer and Director:
“Cardiac surgery and cardiac intensive care: seeking for an harmonious
interaction,” Common Session of
the Working Groups on Congenital
Heart Surgery and Pediatric Cardiac
Intensive Care, AEPC 43rd Annual
Meeting, Venice, Italy (2008).
Stephen R. Daniels, MD, PhD, was
elected to the Hall of Honor by the
Cincinnati Pediatric Society (2007);
Chairman, Nominating Committee
for Council on Cardiovascular
Disease in the Young, AHA (20062008); Steering Committee Member,
Council on Cardiovascular Disease
in the Young, AHA (1999-2008);
Co-Chair, Alliance for a Healthier
Generation, Healthcare Pillar,
AHA (2006-present); Member,
Committee on Nutrition, AAP
(2004-2010); Pediatric Council
Member, AAP Colorado Chapter
(2007-present); Chairman, Youth
Workgroup, Activity and Health
Policy Network, American College of
Sports Medicine (2007); Chairman,
Expert Panel on Cardiovascular Risk
Reduction in Children, NHLBI, NIH
(2006-2008); Chairman, Workshop
on Pediatric Metabolic Syndrome,
NICHD, NIH (2006); Member,
Strategic Planning Working Group,
Vascular Diseases and Hypertension,
NHLBI, NIH (2006); Reviewer,
Study Section, Cardiovascular
Disease and Sleep Epidemiology,
Center for Scientific Review, NIH
(2007-2008); Reviewer, Mentored
Patient-Oriented Research Career
Development Award (K23) and
Mid-Career Investigator Award in
Patient-Oriented Research (K24),
NHLBI, NIH (2007-2008); Reviewer,
Clinical Study Section, Juvenile
Diabetes Research Foundation
Spring Review (2007); Associate
Editor, Journal of Pediatrics
(1995-present); Associate Editor,
Congenital Heart Disease (2005-present); Pediatric Editorial Board
Member, Obesity Management
(2006-present).
D. Dunbar Ivy, MD, received
the Fern Primack “Heart Who
Cares” award from the Little
Hearts Luncheon Committee/
TCH Foundation (2008); Member,
Scientific Leadership Council,
Pulmonary Hypertension
Association (2005-present); 5280
Magazine’s Top Doctors in Denver
(2005-present).
Jonathan Kaufman, MD, received
the Outstanding Young Investigator
Cardiology Award, CHOP (2007).
Michael S. Schaffer, MD, received
the TCH Outstanding Service Award
(2008); Pacemaker Award, AHA
(2007); 5280 Magazine’s Top Doctors
in Denver (2001-present).
Robin Shandas, PhD, was inducted
into the Pinnacles of Inventorship
by the Technology Transfer
Office, UCD (2008); Inventor of the
Year, Technology Transfer Office,
UCD (2006-2007); Distinguished
Achievement Award, Department
of Mechanical Engineering, UCD
(2006-2007).
awards and honors
Wei Tan, PhD, received the
Young Investigator Award from
the Defense Advanced Research
Projects Agency (2008); Research
Institute Scholar Development
Award, TCH (2007); Junior Faculty
Development Award, UCD (2006).
Adel K. Younoszai, MD, was
elected to Best Doctors in America
(2004-2006); Pediatric Echo Bowl
Co-Champion, American Society
of Echocardiography, 16th Annual
Scientific Sessions (2004, 2006);
Cleveland Magazine’s Top Doctors
(2006).
Child Health
Associate/Physician
Assistant Program
Jonathan M. Bowser, MS, CHA/
PA-C, is an invited graduation
speaker, UCD (2008); Member,
Physician Assistant Education
Association Testwriting Packrat
Committee (2007-present).
Anita D. Glicken, MSW, is
Chairman of the Nominations and
Awards Committee for the Physician
Assistant Education Association
(PAEA), (2008-2009); President,
PAEA Board of Directors (20062007); Member, Residency Review
and Redesign in Pediatrics (R3P)
Project Workgroup, ABP (20062007); Member, Physician Assistant
Workgroup Genomic Research
Institute, NIH (2007); Chairman, Data
and Research Workgroup, PAEA
(2006-2008); President’s Leadership
Award, PAEA (2007); Advisory Board,
Institute for Global Health (2007);
Editorial Advisory Board, Journal
of Physician Assistant Education
(2006-2008); Best Innovation
Poster Award, Western Group on
Educational Affairs Spring Meeting
(2006).
Sandra L. Hoops, MS, CHA/PA-C,
received the American Diabetes
Association Outreach Award (2007);
Veritas Award, Center for Bioethics
and Humanities, UCD (2007).
Joyce A. Nieman, MHS, CHA/PA-C,
received the Best Innovation Poster
Award at the Western Group on
Educational Affairs Spring Meeting
(2006).
Christina M. Robohm, MS,
CHA/PA-C, received a Chancellor’s
Diversity Recognition Award for
Faculty Leadership, UCD (2008); Best
Poster Award, Educational Gallery,
American Academy of Physician
Assistants’ 16th Annual Clinical
and Professional Poster Session
(2007); Member, Physician Assistant
Education Association Governance
Committee (2006-present).
Cathleen C. Ruff, MS, CHA/PA-C, is
a member of the Physician Assistant
Education Association Education
Committee (2006-present).
Child Neurology
Jennifer Armstrong-Wells,
MD, MPH, was given the Kaiser
Award for Excellence in Research
in Neuroscience, San Francisco
Neurological Society (2008); Oral
Presenter and Press Conference
Speaker, International Stroke
Conference (American Heart
Association), New Orleans, Louisiana
(2008).
Timothy J. Bernard, MD, was
selected as a Member of the Clinical
Faculty Scholars Program, Colorado
Health Outcomes Program, Clinical
and Translational Sciences Institute,
UCD (2008); Fellow Teaching Award,
TCH (2006); Paul G. Moe Pediatric
Neurology Award, UCD (2006).
Amy R. Brooks-Kayal, MD,
was awarded the Ponzio Family
Endowed Chair in Pediatric
Neurology, TCH (2008); American
Academy of Neurology Leadership
Development Program (2007);
Epilepsy Benchmark Steward, NIH
(2007); Co-Chair of Benchmarks Area
III: Prevent, limit, and reverse the comorbidities associated with epilepsy
and its treatment, NIH (2007); Board
of Directors, American Epilepsy
Society (2006-2009); Associate
Editor, Epilepsia, Journal of the
International League Against
Epilepsy (2006-present).
Carolyn L. Green, MD, is listed in
Best Doctors In America (2005-2008);
Top Docs in Cleveland, Cleveland
Magazine (2006-2008); Certificate of
Excellence, Contribution to Medical
Education, Rainbow Babies and
Children’s Hospital (2007).
Julie A. Parsons, MD, is listed in
5280 Magazine’s Top Doctors in
Denver (2008).
Tonia M. Sabo-Graham, MD,
received the Best Clinic Satisfaction,
Press Ganey Survey (2007).
Amanda Sturgil, RN, MS, CPNP,
received the Sigma Theta Tau
Nursing Award (2006).
Audrey S. Yee, MD, received the
Junior Investigator Travel Award,
Curing Epilepsy 2007, Washington,
DC (2007).
Clinical Genetics
and Metabolism
Gary A. Bellus, MD, PhD, received
the Gold Leadership Circle for
Volunteerism from the American
Academy of Dermatology (2007);
The President’s Volunteer Service
Award, U.S. Government (2007);
Member Making a Difference
Award, American Academy of
Dermatology (2008).
Laurie E. Bernstein, MS, RD,
FADA, is a Member of the Culinary
Nutrition Advisory Board, Johnson
and Wales University (2005-present).
Katheleen Gardiner, PhD, was
Chair of the Genes, Genomes and
Genetics Study Section, NIH (20022007); Member, Science, Research
and Practice Advisory Board of the
Down Syndrome Educational Trust
(2007-present); Member, Molecular
Neurogenetics Study Section, NIH
(2008-present).
Stephen I. Goodman, MD, was
named American Board Medical
Genetics representative to the
Assembly of American Board of
Medical Specialties (2006-2008);
Florence Sabin Award, UCD (2008).
Ying Jin, MD, PhD, received the
Postdoctoral Fellow Training Fund
Award for Frontiers in Statistical
Genetics for National Institute of
Arthritis and Musculoskeletal Skin
Diseases Researchers (2006).
David K. Manchester, MD, is listed
in 5280 Magazine’s Top Doctors in
Denver (2005-2006, 2008).
John R. Sladek, Jr., PhD, received
the Sanberg Lifetime Achievement
Award from the American Society
for Neural Therapeutics and Repair
(2007); Member, Grants Working
Group and Chair of the Review
Board, California Institute for
Regenerative Medicine (2008);
$3 billion Stem Cell Grants Program,
California Institute for Regenerative
Medicine (2008); Special Review
Committee, NIH Eureka Awards
(2008); Section Editor, Neuroscience
and Tissue Engineering, Cell
Transplantation (2008); Chair,
Advisory Board, University of
Wyoming’s $13 Million INBRE
Award (Idea Network of Biomedical
Research Excellence), NIH (2008);
Trustee of Carthage College,
Wisconsin (2004-2008).
Elaine B. Spector, PhD, was elected
secretary of the American College
of Medical Genetics (2007-2009);
Invited Speaker, 4th International
Conference of the Royal Medical
Services, Amman, Jordan (2008).
Johan L. Van Hove, MD, PhD,
is on the Editorial Board, Journal
of Inherited Metabolic Diseases
(2004-present); Scientific Advisory
Board, The European Journal of
Pediatric Neurology (2005-present); Board of Directors, Society
for Inherited Metabolic Disorders
(2007-present); Member, Advisory
Board for Mountain States Genetics
Regional Collaborative Center
(2008-present); Invited Speaker,
American College of Medical
Genetics (Seizures in Neonates and
Infants, Metabolic Causes) (2008);
Member, National Workgroup:
Long-Term Follow-Up of Newborn
Screening, HRSA (2007).
Carol S. Walton, MS, CGC, was
reelected to a third term as Chair of
the Credentials Committee for the
Board of Directors of the American
Board of Genetic Counseling (2008).
Community Pediatrics
Tracy Johnson, PhD, was chosen
as Health Policy Analyst for the
Colorado State 2008 Blue Ribbon
Commission (2007).
Steven R. Poole, MD, received the
Career Teaching Scholar Award
from the Department of Pediatrics,
UCDSOM (2007); Judith M.
Kaufmann Civic Entrepreneurship
Award, The Denver Foundation
(2008).
2006-2008 Departmental Report
149
awards and honors
Critical Care Medicine
Joseph A. Albietz, MD, was
awarded First Prize for SecondYear Fellow Research Poster
Presentation “Pulmonary Vascular
Impedance: The Development of
New Techniques to Assess Right
Ventricular Afterload,” TCH (2007).
Emily L. Dobyns, MD, is listed in
5280 Magazine’s Top Doctors in
Denver (2007-present).
Eva N. Grayck, MD, is Chair of the
Women in Science Committee for
the Society of Free Radical Biology
and Medicine (2006-2007); Best
Doctors in America (2006-2007).
Peter M. Mourani, MD is listed
in 5280 Magazine’s Top Doctors
in Denver (2008); Best Doctors in
America (2007).
Kurt R. Stenmark, MD, is listed as
one of the Best Doctors in America
(2008); America’s Top Pediatricians
(2007); 5280 Magazine’s Top Doctors
in Denver (2007-present).
Dermatology
Joanna M. Burch, MD, is listed in
5280 Magazine’s Top Doctors in
Denver (2007-present).
Joseph G. Morelli, MD, is listed
in 5280 Magazine’s Top Doctors in
Denver (2007-present); Chairman,
Sturge-Weber Foundation Medical
Advisory Board (1999–present).
Lori D. Prok, MD, received the
Dermatology Foundation Resident
Travel Award (2007).
Developmental and
Behavioral Pediatrics
William M. Campbell, MD, received
the U.S. Air Force Meritorious
Service Medal (2nd Oak Leaf Cluster)
(2006).
Edward J. Goldson, MD, received
the James E. Strain Award from
TCH Medical Staff (2006); Kempe
Professional Award, Kempe
Children’s Foundation (2006).
Nicole R. Tartaglia, MD, was the
American Federation for Medical
Research Carmel Scholar (2007).
Developmental Biology
Bruce Appel, PhD, was named
the first Diane G. Wallach Chair in
Pediatric Stem Cell Biology (2008).
Lee Niswander, PhD, was
named Co-Director of the
Embryology Course, Marine
Biological Laboratory, Woods
Hole, Massachusetts (2006-2011);
Associate Director, Graduate
Program in Biomedical Sciences,
UCD (2007-present); Damon
Runyon Scientific Advisory
Committee (2006-2009); Council
Advisory Panel, NIH Developmental
Biology, Genetics, and Teratology
Branch (2006); Editorial Board,
Developmental Biology (2005-present); Harvey Society Lecture,
Rockefeller University (2008); Friday
Evening Lecture, Marine Biological
Laboratories, Rockefeller University
(2007).
Emergency Medicine
Lalit Bajaj, MD, MPH, is listed in
5280 Magazine’s Top Doctors in
Denver (2005-present); Pediatric
Emergency Medicine Education
Award, Department of Pediatrics,
UCDSOM (2007).
Joan P. Bothner, MD, was named
Chief Medical Officer of TCH (2007);
5280 Magazine’s Top Doctors in
Denver (2005-2007).
Louis C. Hampers, MD, MBA,
FAAP, was appointed to the
Committee for Pediatric Emergency
Medicine, AAP (2006-2012); 5280
Magazine’s Top Doctors in Denver
(2007); Sponsor, Kristen Crossman,
Fellow’s Clinical Research Award,
Pediatric Academic Societies (2007).
Shirley McKenzie, PNP-BC, was
selected by the Colorado Nursing
Association to serve on the
Governor’s Advisory Committee on
Collaborative Scopes of Care (2008).
Lara D. Rappaport, MD, MPH, was
appointed by the Governor to serve
on the State Emergency Medical
and Trauma Services Advisory
Council (2008).
Arleta B. Rewers, MD, PhD, MPH,
was named Medical Director for the
Kiwanis Pediatric Trauma Institute
(2007).
1 50 D e p a r t m e n t o f P e d i a t r i c s
Endocrinology
Michael S. Kappy, MD, PhD,
received the Recognition Award
for Lifetime Education in Pediatrics
from St. Joseph’s Hospital and
Medical Center, Phoenix (2007);
Career Teaching Scholar Award,
Department of Pediatrics, UCDSOM
(2007); 5280 Magazine’s Top Doctors
in Denver (2006-present); America’s
Top Doctors (2007).
Kristen Nadeau, MD, was inducted
into the Pediatric Academic
Societies (2007); Outstanding
Investigator Award, American
Federation for Medical Research
Western Chapter (2007).
Sharon H. Travers, MD, is listed
in 5280 Magazine’s Top Doctors in
Denver (2005-present).
Philip S. Zeitler, MD, PhD, is listed
in 5280 Magazine’s Top Doctors in
Denver (2007-present).
Epidemiology
Michael G. Kahn, MD, PhD,
received the Outstanding Research
Mentor Award from the Clinical
Sciences Graduate Training
Program, UCD (2007).
James K. Todd, MD, received the
Distinguished Physician Award
from the Pediatric Infectious
Disease Society (2008); Citation,
Colorado 2008 Healthcare Reform
Commission (2008); 5280 Magazine’s
Top Doctors in Denver (2005-present); Denver’s Top 150 Citizens
(2008).
Gastroenterology,
Hepatology and Nutrition
Glenn T. Furuta, MD, received
a Provisional Application for a
United States Letters Patent for
Minimally-Invasive Measurement
of Esophageal (2007); Member,
International Eosinophil Society
(2003-present); Member, SPR
(2006-present); Executive Board
Chairman, The International
Gastrointestinal Eosinophil
Researchers (2006-present);
Member, National Commission
on Digestive Diseases-Esophageal
Section (2006-present);
Co-Chairman, Mentor Research
Scholar Award, Foundation of the
American Gastroenterological
Association (2006); Co-Chairman,
Eosinophilic Esophagitis
Translational Symposium, Digestive
Disease Week, Washington, D.C.
(2008); Chairman, Eosinophilic
Diseases Working Group, Federation
of International Societies for
Pediatric Gastroenterology,
Hepatology and Nutrition, October
2008, Brazil (2006-2008); Steering
Committee Member, Second
International Gastrointestinal
Eosinophil Research Symposium,
American Academy of Allergy,
Asthma and Immunology, March
2008, Philadelphia (2007-2008);
Editorial Board, Journal of Pediatric
Gastroenterology and Nutrition
(2006-present); Editorial Board,
World Journal of Gastroenterology
(2008); Member, Crohn’s
Colitis Foundation of America
Research Training Award Study
Section (2006-present); Ad Hoc
Study Section, Special Review
Subcommittee for Digestive
Diseases and Nutrition, NIDDK
DDK-C, NIH (2007); Chairman,
Medical Advisory Board, American
Partnership for Eosinophilic Diseases
(2002-present); Honorary Board
of Directors, Campaign for Urgent
Research on Eosinophilic Diseases
(2008); Best Doctors In America
(2007-present); Co-Chairman,
Eosinophilic Oesophagitis
Symposium, World Congress of
Oesophagology, Monaco (2008);
Chairman, Autism Speaks-Allergy
Committee, Massachusetts General
Hospital, Boston, Massachusetts
(2007); Member, Autism Treatment
Network-GI/Allergy Committee,
Denver, Colorado (2008); Abstract
Chairman, Eosinophilic Esophagitis
Section, Digestive Disease Week
(2006-2009); Member, Research
Council, North American Society
of Pediatric Gastroenterology,
Hepatology and Nutrition
(2008-2011); Invited Member,
National Institute of Allergic and
Immunological Diseases Food
Allergy Clinical Practice Guidelines
Coordinating Committee (20082010).
awards and honors
Edward J. Hoffenberg, MD,
was Chair of the International
Committee for NASPGHAN (20042007); Scientific Advisory Board,
Celiac Disease Initiative, Children’s
Digestive Health and Nutrition
Foundation (2003-present); 5280
Magazine’s Top Doctors in Denver
(2007-2008).
Robert E. Kramer, MD, is listed as
one of the Best Doctors in America
(2005-present); Delegate, National
Association of Children’s Hospitals
and Related Institutions, Obesity
Focus Committee and Bariatric
Task Force (2008); Member,
American Society of Gastrointestinal
Endoscopy (2007-present).
Cara L. Mack, MD, received the
Biliary Atresia Research Initiative
Award from American Liver
Foundation (2006-2008); March
of Dimes Basil O’Connor Starter
Scholar Research Award (20052007); Pediatric Research Abstract
Award, American Association for
the Study of Liver Disease (2005);
Invited Speaker, NIH Workshop:
Screening and Outcomes in Biliary
Atresia (2006); Invited Speaker,
AASLD Henry and Lillian Stratton
Basic Research Single Topic
Conference: Pathobiology of Biliary
Epithelia and Cholangiocarcinoma
(2008).
Michael R. Narkewicz, MD, was
named President of The Children’s
Hospital Medical Staff (20062008); Chairman, Chronic Viral
Hepatitis Guidelines Committee,
NASPGHAN (2003-present);
Co-Chairman, Children’s Digestive
Health and Nutrition Foundation
Pediatric Viral Hepatitis Public
Awareness Campaign; Medical
Advisory Committee, American
Liver Foundation (2004-present);
Scientific Advisory Board Member
and Grant Steering Committee
Member, Studies of Pediatric
Liver Transplantation (2004-2008);
5280 Magazine’s Top Doctors
in Denver (2005-present); Best
Doctors in America (2005-present); Associate Editor, Journal of
Pediatric Gastroenterology and
Nutrition (2001-2011); Member,
Training Committee, NASPGHAN
(2007-2010); Chairman, Evaluation
Committee, Pediatric Scientist
Training Program (2004-present).
Jason Soden, MD, is a Member
of the Pediatric Intestinal Failure
Consortium (2008-present).
Ronald J. Sokol, MD, is Principal
Investigator and Director of the
Colorado Clinical and Translational
Sciences Institute, NCRR, NIH
(2008-2013); National Commission
for Digestive Diseases, Liver and
Biliary Systems Working Group, NIH
(2006-present); Chair, Advocacy
Committee, NASPGHAN (20072008); Chair, Steering Committee
for the Biliary Atresia Research
Consortium, NIDDK, NIH (20022009); Member, Medical Advisory
Board for the Alagille Syndrome
Alliance (2003-2007); Liver Action
Plan Committee Member, NIDDK,
NIH (2004-present); Chair and
Principal Investigator, Cholestatic
Liver Disease Consortium, ORD/
NCRR/NIDDK, NIH (2004-2009);
Chair, Steering Committee of Rare
Diseases Clinical Research Network,
ORD/NCRR, NIH (2006-2009); Grant
Steering Committee and Scientific
Advisory Board Member, Studies
in Pediatric Liver Transplantation,
NIDDK, NIH (2004-2009); Member,
Liver and Biliary Systems Working
Group, NCDD, NIH (2006-2007);
Special Emphasis Review Panel,
NIDDK, NIH (2006, 2008); National
Board of Directors, American Liver
Foundation (2007-2010); Public
Policy/Advocacy Task Force,
American Association for the
Study of Liver Diseases/American
Liver Foundation (2008-present); Publications Committee,
NASPGHAN (2006-present); 5280
Magazine’s Top Doctors in Denver
(2006-present); Best Doctors in
America (2005-2008); Who’s Who
in Medicine and Healthcare (20042007); America’s Top Pediatricians
(2002-2006); Scientific Advisory
Committee, Children’s Research
Institute, Children’s National
Medical Center, Washington, D.C.
(2004-2007); Who’s Who in America
(2005-2007); Associate Editor,
Seminars in Liver Disease (2004-present); Editorial Board Member,
Hepatology (2005-present).
General Academic Pediatrics
Stephen Berman, MD, was
named Chair of the Helping the
Children Task Force of the AAP in
collaboration with the World Health
Organization (2006); Ambulatory
Pediatric Association’s Advocacy
Award, Pediatric Academic Societies
(2007); The Children’s Hospital Chair
in General Pediatrics (2007); Author,
Getting it Right for Children: Stories
of Pediatric Care and Advocacy
(2007); Career Teaching Scholar
Award, Department of Pediatrics,
UCDSOM (2008).
Ellen Roy Elias, MD, is an Executive
Committee Member of the Section
on Children with Disabilities of the
AAP (2004-2007); Editor, 4th edition
Developmental/ Behavioral Pediatrics
(2005-2008).
David Fox, MD, received the
Gary Way Award for Outstanding
Teaching from the Department of
Pediatrics, UCDSOM (2007).
Mary C. Kohn, MD, received an
Oustanding Teacher Award by the
UCD Family Medicine Residents
(2007).
N. Elaine Lowery, JD, MSPH,
was appointed to the American
Immunization Registry Association
Board of Directors (2007).
Elaine H. Morrato, MPH,
DrPH, is a Consultant to the
Risk Communication Advisory
Committee, FDA (2007-present).
Shale L. Wong, MD, MSPH,
received the Chancellor’s Diversity
Recognition Award, UCD (2007).
Hematology, Oncology and
Bone Marrow Transplantation
Deborah A. DeRyckere, PhD, was
named New Inventor of the Year,
Technology Transfer Office, UCD
(2007).
Jorge DiPaola, MD, was named
the Postle Family Chair in Pediatric
Cancer and Blood Disorders (2008).
Robert L. Garcea, MD, was named
Inventor of the Year, Technology
Transfer Office, UCD (2006).
Roger H. Giller, MD, selected as
one of the Best Doctors in America
(1998-present); Board Member,
Brent Eley Foundation (2003-present); Outstanding Service Award,
TCH Medical Staff (2006).
Neil A. Goldenberg, MD, PhD,
received a Bayer Early Career
Investigator Award (2006-2008);
Chair of Steering Committee,
ECLECTIC – International Clinical
Trial in Peripheral Arterial
Disease (2008-2009); Chair of
Steering Committee, DaVINCI –
National Clinical Trial in Pediatric
Cancer-Associated Venous
Thromboembolism (2008-2009);
Advisor, National Hemophilia
Foundation Baxter Fellowship
Training Award Program (2008);
Member, Brain Committee, NHLBI
Conference on Clinical Research
Priorities in Sickle Cell Disease
(2008).
Lia Gore, MD, is Co-Founder
and Co-Director of the Pediatric
Experimental Therapeutics
Investigators Consortium
(2002-present); Co-Chair, Cytotoxic
Chemotherapy Committee and
Member, Program Committee,
American Society of Clinical
Oncology (2005-2008); Member,
Executive Committee on Acute
Lymphoblastic Leukemia, Children’s
Oncology Group (2005-present);
Distinguished Visiting Professor,
Alberta Children’s Hospital and
the University of Calgary, Ontario,
Canada (2006); Physician of the
Year, Rocky Mountain Chapter of
National Association of Pediatric
Nurse Practitioners (2007); Best
Doctors in America (2005-present); America’s Best Oncologists
(2007); New Inventor of the Year,
Technology Transfer Office, UCD
(2007).
Douglas K. Graham, MD, PhD,
received the Damon RunyonNovartis Clinical Investigator Award
(2007); Research Scholar Award,
American Cancer Society (2008);
Ad Hoc Member, Study Section on
Hematopoiesis, NIH (2008); New
Inventor of the Year, Technology
Transfer Office, UCD (2006);
Children’s Oncology Group Young
Investigator Award (2006); Colorado
Bioscience Discovery Award (2007).
2006-2008 Departmental Report
151
awards and honors
Brian S. Greffe, MD, received the
Champions in Healthcare Award
for Best Outreach Program (The
Butterfly Program), Denver Business
Journal (2007); 5280 Magazine’s Top
Doctors in Denver (1998-1999 and
2002-present); Award of Courage,
Porter/Hospice Foundation (2006).
Taru Hays, MD, is listed in 5280
Magazine’s Top Doctors in Denver
(2005-present).
Molly Hemenway, ND, RN, AC/
CPNP, is the first recipient of the
J. Patrick Barnes Research Grant
(2008).
Stephen P. Hunger, MD, was
named Ergen Family Chair in
Pediatric Cancer (2007); Chairman,
Children’s Oncology Group, Acute
Lymphoblastic Leukemia (ALL)
Committee (2007); Best Doctors in
America (2007).
Amy K. Keating, MD, is recipient of the Career Development
Award, St. Baldrick’s Foundation
(2008); Professional Development
Award, TCH Research Institute
(2008); Ruth L. Kirshstein National
Research Service Award (20042006); Pediatric Academic Societies
Young Investigator Award (2006);
Outstanding Fellow Research
Award, UCD (2006).
Jennifer R. Madden, RN, MSN,
CPNP, received the DAISY (Disease
Attacking the Immune System)
Award for extraordinary nursing at
TCH (2006).
Marilyn J. Manco-Johnson, MD,
published a landmark paper in The
New England Journal of Medicine:
“Prophylaxis versus Episodic
Treatment to Prevent Joint Disease
in Boys with Severe Hemophilia”
(2007); Researcher of the Year,
National Hemophilia Foundation
(2007); Chair, American Society of
Hematology Pediatric Education
Symposium (2008); Chair, NIH
Consensus Subcommittee on
Management of von Willebrand’s
Disease (2004-2007); Member,
Surgeon General’s Workshop on
Deep Vein Thrombosis (2006);
Member, NHLBI Strategic Plan, NIH
(2006); Symposium Presentations,
International Society of Thrombosis
and Haemostasis and Japanese
Society of Hematology (2007);
Symposium Presentations,
International Society of Hematology
(2006, 2008)
Rachelle Nuss, MD, received the
Charles C. Shepard Award for the
Best Manuscript in the Category of
Prevention and Control, CDC (2007);
Best Doctors in America (2007).
Christopher Porter, MD, received
the Paul Calabresi Award in Clinical/
Translational Oncology Research
Award (2008); Brent Eley and Brian
Hicks Research Award (2006).
Christopher C. Silliman, MD, PhD,
was inducted into the National
Blood Foundation Hall of Fame
(2007).
Infectious Diseases
Mark J. Abzug, MD, is listed in
America’s Top Pediatricians (2006);
5280 Magazine’s Top Doctors in
Denver (2005-2007); Best Doctors
in America (2005-2008); America’s
Top Physicians (2007); Member,
Subboard of Pediatric Infectious
Diseases, ABP (2005-present);
Associate Editor, Journal of
Clinical Virology (2005-present);
Chair, Enterovirus Subcommittee,
Collaborative Antiviral Study
Group, NIAID, NIH (2000-2006);
Member, Complications Scientific
Committee, International Maternal
Pediatric Adolescent AIDS Clinical
Trials Group, NIH (2006-present);
Vice Chairman, Long-Term FollowUp Subcommittee, International
Maternal Pediatric Adolescent AIDS
Clinical Trials Group, NIH (2006-present); Invited Contributor, 2009 Red
Book: Report of the Committee on
Infectious Diseases, AAP (2007).
Marsha S. Anderson, MD, is
listed in America’s Top Pediatricians
(2004-2006).
Emily A. Barr, CPNP, CNM, was
awarded The Children’s Hospital
DAISY Award for Excellence in
Nursing (2006).
Samuel R. Dominguez, MD, PhD,
received the Individual Pediatric
Infectious Disease Research
Fellowship Award from the Pediatric
Infectious Disease Society (20052007); Pediatric Infectious Disease
Fellow Top 5 Poster Award (2006);
First Prize, Fellow Poster, Infectious
Disease Society of America (2006).
Mary P. GlodГ©, MD, is listed in 5280
Magazine’s Top Doctors in Denver
(2005-present); Special Recognition
Award, Dedication and Service
to Recruitment, Department of
Pediatrics, UCDSOM (2007); Charles
C. Shepard Science Award, Scientific
Excellence demonstrated by the
publication of the Pneumococcal
Vaccine Study in the Lancet, CDC
(2007); Red Book Committee on
Infectious Disease, AAP (2007-2011);
Invited Speaker, International
Kawasaki Symposium (2008).
Myron J. Levin, MD, was inducted
into the Pinnacles of Inventorship
by the Technology Transfer Office,
UCD (2008); developed and licensed
a new shingles vaccine (2006).
Elizabeth J. McFarland, MD, is
listed in Best Doctors in America
(2003-present); Vice Chair, Vaccine/
Immune-Based Therapy Scientific
Committee for International
Maternal Pediatric Adolescent AIDS
Clinical Trials, NIH (2005-present);
Editorial Board, Clinical Vaccine
Immunology (2006-present); Clinical
Investigators Group, Pediatric
AIDS/HIV Cohort Study (2006-present); Outstanding Contribution
in HIV Service Award, Association
of Nurses in AIDS Care, Colorado
(2007); America’s Top Physicians
(2007); Who’s Who Among American
Teachers and Educators (2007).
Ann-Christine Nyquist, MD,
MSPH, received the Charles
C. Shepard Award for the Best
Manuscript in the Category of
Prevention and Control, CDC (2006).
John W. Ogle, MD, is listed in 5280
Magazine’s Top Doctors in Denver
(2005 and 2008).
Sarah K. Parker, MD, received a
Potts Foundation Grant (2007-2008);
Research Scholar Award (20072008); Selected to attend the Early
Career Women Faculty Professional
Development Seminar (2008);
American Lung Association Grant
(2008-2010).
Suchitra Rao, MD, was awarded
the Jonathan Freeman Scholarship
in Healthcare Epidemiology (2008).
Clinical Faculty Recognition Dinner Awardees l-r: Norman Scott, MD, Noah Makovsky, MD, Lawrence Wolk, MD, MSPH,
Ellen Brooks, MD, David Brooks, MD, Jeffrey Silverman, PA-C, (accepting for Kimberly Thomas, PA-C)
1 52 D e p a r t m e n t o f P e d i a t r i c s
awards and honors
Harley A. Rotbart, MD, is listed in
Best Doctors in America (1996-present); published a children’s book,
The On Deck Circle of Life: 101 Lessons
from the Dugout (2007); published
a book, Germ Proof your Kids: The
Complete Guide to Protecting (without Overprotecting) your Family from
Infections (2007).
Adriana Weinberg, MD, is
Associate Editor of the Journal of
Clinical Virology (2005-present);
Chair, Cryopreservation Optimization
Group, NIH Division of AIDS (DAIDS)
-Sponsored Networks (2007-present); Vice Chair, Immunology
Quality Assurance Advisory Group,
International Maternal, Pediatric and
Adolescent AIDS Trials (IMPAACT)
(2008-present); Member, IMPAACT
Vaccine Scientific Committee
(2006-present); Member, IMPAACT
Laboratory Committee (2006-present); Member, ACTG Optimization
of Co-Infection and Co-Morbidity
Management (OpMAN) Committee
(2007-present).
Kempe Center for the
Prevention and Treatment of
Child Abuse and Neglect
The Children’s Hospital Board of
Directors issued a Resolution on
November 13, 2008, Honoring 50th
Year Anniversary of Child Protection
Team.
Denise Abdoo, RN, MSN, CPNP, is
the Co-Editor, Caring for Our Future,
The Children’s Hospital (2006-present); Board Member and Education
Co-Chair, Rocky Mountain National
Association of Nurse Practitioners
(2005-2008).
Donald C. Bross JD, PhD,
is Director of Lea for Justice
(2004-present); Board Member,
North Metro Children’s Advocacy
Center (1998-2008).
Antonia Chiesa, MD, was appointed by the Governor to the Colorado
Child Fatality Review Committee
(2008).
Edward Garrido, PhD, was
awarded a Research Supplement
to Promote Diversity in Health
Related Research Program, Fostering
Healthy Futures Efficacy Trial for
Preadolescent Youth in Foster Care,
National Institute of Mental Health
(2008).
Richard D. Krugman, MD, was
selected as the Kempe Lecturer
by the International Society for
Prevention of Child Abuse and
Neglect, Hong Kong (2008);
Member, Healthier Princeton
Advisory Board, Princeton
University (2006-2009); Co-Chair,
Quality Task Force, Denver Health
(1997-present); President, University
Physicians, Inc. (1990-present).В В В Gail Ryan, MA, was named a
Distinguished Practitioner by
the Association for Treatment of
Sexual Abusers (2006); Lifetime
Achievement Award, Colorado
Association for Treatment of Sexual
Abusers (2006).
Andrew P. Sirotnak, MD, is
President-Elect of the Medical Staff
at TCH (2008) and will serve a fouryear term on The Children’s Hospital
Board of Directors (2008-2012);
Champions in Healthcare Award,
Denver Business Journal (2007);
Recognition Award for “Leadership
of the Physician Liaison Program and
the Tremendous Contribution Made
to our Successful Hospital Move,” TCH
(2007); Visiting Professor, Pediatric
Grand Rounds, Thomas Jefferson
Medical College, Department
of Pediatrics and A.I. DuPont
Children’s Hospital, Wilmington,
DE (2007); Guest Editor, Pediatric
Clinics of North America: Child
Abuse and Neglect: Advancements
and Challenges for the 21st Century
(2008).
Lucinda T. Tanner, CHA/PA, was
named Kempe Professional of the
Year, Kempe Children’s Foundation
(2008).
Heather N. Taussig, PhD, was
appointed to the Governor’s
Task Force on Foster Care and
Permanence (2007).
Neonatology
Laura D. Brown, MD, received
a K12 Building Interdisciplinary
Research Careers in Women’s Health
(BIRCWH) Career Development
Program Scholar Award, NIH
(2008-present).
Jacob E. Friedman, PhD, was
nominated President of the
American Diabetes Association
Council on Reproductive Sciences
(2008); Joseph Hoet Prize,
Outstanding Scientific Achievement,
International Society for the
Study of Diabetes and Pregnancy
(2008); Mentor-Based Postdoctoral
Fellowship, American Diabetes
Association (2008-2012); Elected
Member, Perinatal Research Society
(2008); Ad Hoc Study Section,
Building Interdisciplinary Research
Team Awards, National Institutes
of Arthritis and Musculoskeletal
Diseases (NIAMS), NIH (2008); Ad
Hoc Study Section, Integrative
Physiology of Obesity and
Diabetes (IPOD), NIDDK, NIH (20072008); Ad Hoc Chair, NIH Small
Business Innovation, Research
and Technology Transfer in
Diabetes (SBIR-STTIR), Obesity and
Nutrition, NIDDK, NIH (2007-2008);
Member, Ad Hoc Study Section,
Endocrinology, Metabolism,
Nutrition and Reproductive Sciences
(EMNR), NIDDK, NIH (2007-2008);
Ad Hoc Study Section, Cellular and
Molecular Aspects of Diabetes
and Obesity (CADO), NIDDK, NIH
(2007-2008); Ad Hoc Study Section,
Fellowships in Endocrinology,
Metabolism, Nutrition and
Reproductive Sciences IRG, NIH
(2008); National Institutes of Aging
Special Emphasis Review Panel:
Adiposity, Aging, and Stem Cells,
NIH (2008); External Advisory Board,
European Association for the Study
of Diabetes and Pregnancy (20062007); Diabetes Research Review
Panel, United Kingdom (2008);
Member, Program Committee
and Abstract Reviewer, American
Diabetes Association National
Meetings (2007-2008); Abstract
Reviewer, 2008 Annual Obesity
Society Scientific Meetings (2008);
Editorial Board, The Journal of
Biological Chemistry (2006-2011);
Editorial Board, American Journal
of Physiology: Endocrinology &
Metabolism (1995-2006); Editorial
Board, Archives of Physiology and
Biochemistry (2005-present).
Theresa R. Grover, MD, is listed in
Best Doctors in America (2007-2008).
William W. Hay, Jr., MD, was
President of the American Pediatric
Society (2008); Member, Pediatric
Oversight Committee, NIH CTSA
Consortium Child Health Oversight
Committee (2008-present); Chair,
NIH CTSA Consortium Child Health
Oversight Committee Working
Group on Pediatric-Adult Lifespan
Research (2008-present); Council
Member, Western Society for
Pediatric Research (2007-2012);
Co-winner, 1st Society for Pediatric
Research “Research Conference,”
Interplays Between Early Nutrition,
GI Microbial Ecology, the Immune
System and Subsequent Health
(2007); Trustee, International
Pediatric Research Foundation
(2004-2009); Member, APS/SPR
Student Research Program Steering
Committee (2008-present); Editor,
NeoReviews, American Academy
of Pediatrics (1998-present);
Editorial Board, American Journal
of Physiology: Endocrinology and
Metabolism (2007-2009); Editorial
Board, Reproduction, Fertility
and Development (1995-present); Editorial Board, Trophoblast
Research (2001-2009); Co-Chair,
NIH Symposium on Neonatal
Hypoglycemia (2008); March of
Dimes Agnes Higgins Award (2006);
Member, NCRR Institutional Clinical
Translational Science Award, Special
Emphasis Review Panels (20062007).
Jacinto A. HernГЎndez, MD, MHA,
received a Distinguished Alumni
Award, from the Alumni Association
of San Juan National High School of
Trujillo, Peru (2007); Neonatology
Symposium of the III International
Pediatric Course was named “Dr.
Jacinto A. Hernandez,” Universidad
Peruana Cayetano Heredia of
Lima, Peru, (2007); Humanitarian
Award, Board of Trustees of Avista
Adventist Hospital (2007).
Peter Hulac, MD, is President of the
Colorado Healthcare Ethics Forum
(2007-2009).
Jason Gien, MD, received the L.
Joseph and Perry Butterfield Award
in Perinatal Pediatrics, from the
Department of Pediatrics, UCDSOM
(2007); Young Investigator’s Travel
Award, Pediatric Academic Societies
(2007).
2006-2008 Departmental Report
153
awards and honors
M. Douglas Jones, Jr., MD, was
named the recipient of the Joseph
W. St. Geme, Jr. Leadership Award
by the Federation of Pediatric
Organizations (2008); Member,
Committee on Innovation in
the Learning Environment,
Accreditation Council for Graduate
Medical Education (2005-2009);
Member, Subspecialties Committee,
ABP (2002-present); Member,
New Subspecialties Committee,
ABP (1996-present); Festschrift
Educational Symposium, The Future
of Pediatrics, UCDSOM and TCH
(2006); Member, Neonatal-Perinatal
Self-Assessment Committee, ABP
(2004-present); Chair, Residency
Review and Redesign in Pediatrics
(R3P) Project Committee, ABP
(2005-present); Chair, Finance
Committee, ABP (2006-2007);
Member, Finance and Executive
Committees, ABP (2007-2008);
Chair-Elect, Board of Directors, ABP
(2007-2008); 46th Annual Joseph
Bilderback Lectureship, Oregon
Health and Science University
(2008).
Beena D. Kamath, MD, MPH,
received the President’s Award for
Working Together, UCD (2007);
Robinson Durst Scholarship for
Global Health, UCD (2008); L.
Joseph and Perry Butterfield Award,
Department of Pediatrics, UCD
(2008); AAP Section of Perinatal
Pediatrics Travel Grant (2008).
John P. Kinsella, MD, published
a paper entitled “Early Inhaled
Nitric Oxide Therapy on Premature
Newborns with Respiratory Failure”
in the New England Journal of
Medicine that was nominated as
the favorite paper of 2006 by The
Lancet International Advisory Board
(2006); 5280 Magazine’s Top Doctors
in Denver (2008); AAP Section of
Perinatal Pediatrics Travel Grant
(2008).
Susan Niermeyer, MD, was named
Editor of Helping Babies Breathe,
a Global Curriculum in Neonatal
Resuscitation, AAP (2007).
Mizanoor Rahman, PhD, received
the Research Day Award for
Outstanding Poster, Department of
Medicine, UCD (2007).
Regina M. Reynolds, MD, received
the President’s Award for Working
Together, UCD (2007).
Adam A. Rosenberg, MD, was
given the Partners in Care Award by
UCH (2008); 5280 Magazine’s Top
Doctors in Denver (2005-present).
Paul J. Rozance, MD, received
the President’s Award for Working
Together, UCD (2007); Perinatal
Research Society (2008); Speaker,
Perinatal Research Society Rising
Investigator Forum (2008).
Elizabeth H. Thilo, MD, was listed
as one of the Best Doctors in America
(2007-2008).
Patti J. Thureen, MD, was nominated to Who’s Who in America
(2008); Who’s Who in Healthcare
(2008); Who’s Who in Medical
Science Education (2006); Research
Conference Award, SPR (2007).
Randall B. Wilkening, MD, was
elected first Vice President of the
UPI Board of Directors (2007); Best
Doctors in America (2007-2008).
Nephrology
Melissa A. Cadnapaphornchai,
MD, is listed in 5280 Magazine’s
Top Doctors in Denver (2006-present); Who’s Who Among Executive
Professionals (2007); Thai Physicians
Foundation Medical Research
Award (2007).
Douglas M. Ford, MD, is listed in
5280 Magazine’s Top Doctors in
Denver (2005-present); Best Doctors
in America (2006-present).
Gary M. Lum, MD, is listed in
5280 Magazine’s Top Doctors in
Denver (2005-present); Best Doctors
in America (1997-present); Who’s
Who in Medicine and Health Care
Professionals (1999-present); Guide
to Best Doctors (1999-present);
America’s Top Physicians (2004present).
Nutrition
Susan L. Johnson, PhD, received
the Dean’s Graduate School
Mentoring Award, UCD (2007);
Associate Editor, Journal of Nutrition
Education and Behavior (2008).
1 54 D e p a r t m e n t o f P e d i a t r i c s
Nancy F. Krebs, MD, was listed
among America’s Top Pediatricians
(2008); Member, American Society
for Nutrition (1990-present);
Executive Board, International
Society for Research in Human
Milk and Lactation (1986-present); Member, SPR (1996-present);
Member, American Pediatric Society
(2007-present).
Catherine Romaniello, MPH,
RD, received the Outstanding
Dietitian of the Year Award from
the Colorado Dietetic Association
(2006).
Pediatric Hospital Medicine
Julie Noffsinger, MD, received the
Gary Way Award in Pediatrics (20072008).
L. Berry Seltz, MD, received the
CanMEDS Competencies Award,
Subspecialty Pediatric Trainee
from the Department of Pediatrics,
The Hospital for Sick Children,
Toronto, Ontario (2008); Best
Inpatient Clinical Teaching Award,
Department of Pediatrics, University
of Arizona (2006).
Prevention Research Center
for Family and Child Health
David L. Olds, PhD, was given an
Honorary Professorship at Warwick
Medical School in Coventry, England
(2008); Honorary Member, Sigma
Theta Tau International Nursing
Society (2007); Stockholm Prize
in Criminology, Swedish Ministry
of Justice (2008); Sulzberger
Distinguished Lecturer, Duke
University (2008).
Pulmonology
Steven H. Abman, MD, is the
Associate Editor of the American
Journal of Respiratory and Critical
Care Medicine (2006-present);
Jerry Elliot Memorial Lecture,
27th Annual Western Conference
on Perinatal Research, Rancho
Mirage, California (2006); Nils W.
Svenningsen Memorial Lecture,
22nd International Workshop on
Surfactant Replacement, Ancona,
Italy (2007); International Fellow,
Pulmonary Vascular Research
Institute (2007); International Task
Force, 4th World Symposium on
Pulmonary Hypertension (2007).
Frank J. Accurso, MD, received
a Career Teaching Scholar award
from the Department of Pediatrics,
UCDSOM (2006); Deputy Editor,
American Journal of Respiratory and
Critical Care Medicine (2004-2006);
Editorial Board Member, Advances
in Pediatrics (2004-2007); Member,
Board of Trustees, National Cystic
Fibrosis Foundation (2003-present); 5280 Magazine’s Top Doctors
in Denver (2005-present); Breath of
Life Award, Denver Chapter, Cystic
Fibrosis Foundation (2008).
Christopher D. Baker, MD,
received a Fellow Career
Development Award from the
American Thoracic Society (2008);
Fellow Award, Best Poster, Annual
Pediatric Poster Session, TCH (2008);
American Thoracic Society Travel
Award, Presenter, Fellow’s Clinical
Chest Rounds, San Francisco,
California (2007); American College
of Chest Physicians Travel Award,
Presenter, Celebrating Pediatric
Pulmonology Conference, San
Antonio, Texas (2007).
Robin R. Deterding, MD, was
selected by UCDSOM for the
AAMC’s Executive Leadership in
Academic Medicine Program for
Women (2008); Chair, Scientific
Board for Children’s Interstitial
Lung Disease (ChILD) Foundation
(2004-present); Board of Directors,
ChILD Foundation (2004-present);
5280 Magazine’s Top Doctors in
Denver (2005-present); Best Doctors
in America (1998-present).
Norman Friedman, MD, was
named one of the Best Doctors in
America (2007-2008); Head and
Neck Surgery Honor, American
Academy of Otolaryngology
(2008); Appointed Member,
Adult Obstructive Sleep Apnea
Taskforce, American Academy of
Sleep Medicine (2008); Invited
Speaker, 26th Annual Conference
of Sleep Medicine of Infants and
Children (2008); Invited Speaker,
4th Annual Pediatric Sleep Medicine
Conference (2008); Guest Speaker,
International Symposium, Surgery
Sleep and Breathing II (2006).
Ann Halbower, MD, is listed in
Best Doctors in America (2006-2008);
Member, Subboard of Pediatric
Pulmonology, ABP (2008-2012);
Editorial Board, CHEST (20072011); Consultant, Senate Staff,
awards and honors
Pediatric Medical Devices Safety
and Improvement Act, American
Thoracic Society (ATS) (2007-present); Vice Chair, Health Policy
Committee, ATS (2008-2009); HSS/
FDA Consultant, Medical Devices
Advisory Committee (2008-2012);
Program and Planning Committee,
Respiratory Neurobiology and
Sleep Assembly, ATS (2008-2009);
ATS Representative, Guidelines
Committee on Obstructive Sleep
Apnea, AAP (2008-2009); Invited
Contributor, 2008 Case Book of Sleep
Medicine, International Classification
of Sleep Disorders (2008).
Gwendolyn S. Kerby, MD, was
appointed Co-Chair of the Colorado
Asthma Guidelines Committee,
Colorado Clinical Guidelines
Collaborative (2007-2008).
Gary L. Larsen, MD, was listed
in Who’s Who in the World (2006);
Who’s Who in Medicine and
Healthcare (2006-2007); Top Docs,
Core Magazine (2007).
Scott D. Sagel, MD, is Chair of the
Inflammatory Biomarkers Working
Group, Cystic Fibrosis Foundation
Therapeutics Development Network
(2004-present); Member, SPR
(2006-present); Quality Care Award:
Recognizing Outstanding QI Processes
and Accomplishments, Cystic Fibrosis
Foundation (2008); Learning and
Leadership Collaborative, Quality
Improvement Initiative, Cystic
Fibrosis Foundation (2006); FamilyCentered Care Award, TCH (2007);
Best Doctors in America (2007); 5280
Magazine’s Top Doctors in Denver
(2007-2008).
Jeffrey S. Wagener, MD, received
the Outstanding Clinician Award
from the American Thoracic Society
(2008); Outstanding Clinician Award,
Colorado Thoracic Society (2008);
Board Member, Colorado Cystic
Fibrosis Foundation (1996-present); Steering Committee Member,
Cystic Fibrosis Foundation EPIC Trial
(2007-present).
Edith Zemanick, MD, received the
Outstanding Master of Science in
Clinical Sciences Student Award
(awarded to the MSCS student with
the highest GPA), UCD (2006).
programs
Center for Bioengineering
Robin Shandas, PhD, received
the Outstanding Research Award
from the Department of Mechanical
Engineering, UC Boulder (2008);
Inventor of the Year, UCDSOM
(2007); Distinguished Achievement
Award, College of Engineering
and Applied Science, UC Boulder
(2006); NIH K-24 Mid-CAREER
Award in Translational Research
(2006); Dean’s Faculty Fellowship,
College of Engineering and Applied
Sciences, UC Boulder (2006);
Bioengineering Review Panel, Small
Business Innovation Research,
National Science Foundation (20022006); Fellowship Training Study
Section, NHLBI, NIH (2003-2006);
Research Grants Study Section,
American Heart Association
(2006); Chairman, Minority T32
Study Section, National Institute
of Technology Management,
NIH (2008); T32 Study Section
Permanent Member, NHLBI, NIH
(2006-2012).
Wei Tan, PhD, received the
Research Scholar Development
Award, TCH (2007-2008); DARPA
Young Investigator Award (2008);
Junior Faculty Development Award,
UC Boulder (2006).
Timothy Scott, PhD, received a
Vice Chancellor’s Commendation
for Doctoral Thesis Excellence from
Monash University (2006); American
Institute of Chemists Postdoctoral
Award, Department of Chemical
and Biological Engineering, UC
Boulder (2006).
Center for Human Nutrition
James O. Hill, PhD, received
the McCollum Award, American
Society for Nutrition (2007); TOPS
Award, NAASO the Obesity Society
(2007); President, American Society
for Nutrition (2008-2009); Chair,
Steering Committee of Shaping
America’s Health (2008-present); Member, American Heart
Association Physical Activity
Committee (2006-present).
Paul S. MacLean, PhD, served
as Co-Chair for RACMEM, “Recent
Advances and Controversies
in the Measurement of Energy
Metabolism,” International
Methodological Meeting, Denver,
Colorado (2008).
Children’s Outcomes
Research Program
Awards and Honors are listed in each
investigator’s section/program.
Clinical Trials Organization
Awards and Honors are listed in each
investigator’s section/program.
Medical Education
Jacqueline J. Glover, PhD, is a
Member of the Ethics Committee
of the ABP (1990-present);
Professionalism Project Member,
ABP and the Committee on
Bioethics of the AAP (2001-present);
Task Force, Clinical Ethics, American
Society for Bioethics and Humanities
(2001-present).
Mary P. GlodГ©, MD, received a
Special Recognition Award for
Outstanding Dedication and
Service, Residency Recruitment
Selection Committee, Department
of Pediatrics, UCDSOM, (2006-2007).
Department of Pediatrics
Teaching Awards 2005-2006
Erin Ambardekar, MD
Continuity Practice Award
Lalit Bajaj, MD, MPH
The Gary Way Award for
Outstanding Teaching
Timothy Bernard, MD
Outstanding Fellow Teaching
Award, Critical Care
Amber Bisgard, MD
Bruce Garber Memorial Award for
Outstanding Senior Resident
Kelley duFord, MD
Pediatric Emergency Medicine
Award
Jason Gien, MD
Best Second-Year Fellow Poster
Award: Chronic Intrauterine
Pulmonary Hypertension Impairs
Angiogenesis and Growth of Ovine
Fetal Pulmonary Artery Endothelial
Cells In Vitro
Christine Jelinek, MD, David Kane,
MD, Kristine Knuti, MD, Ingrid
Lundgren, MD, and Michelle
Mills, MD
Outstanding Service in Medical
Student Teaching
Julie Kanter, MD, and
Brandy Lu, MD
Joseph W. St. Geme, Jr., MD, Award
for Outstanding Research by a
Resident
Amy Keating, MD
Best Third-Year Fellow Poster
Award: The Aberrant Expression
of Mer Receptor Tyrosine Kinase in
Pediatric Astrocytomas
Deniz Kolozs, MD
C. Henry Kempe Award for
Outstanding Clinical Teacher
Claudia Kunrath, MD
Best First-Year Fellow Poster Award:
Evaluation of Adrenal Reserve
and Response to Low-Dose Acth
(Corticotropin) Stimulation in
Critically Ill Children
Regina M. Reynolds, MD
The L. Joseph and Perry Butterfield
Award in Perinatal Pediatrics
Andrew P. Sirotnak, MD
Special Recognition Award for
Outstanding Dedication and
Service, Residency Recruitment
Selection Committee
Department of Pediatrics
Teaching Awards 2006-2007
Joseph Albietz, MD
Best Second-Year Fellow Poster
Award: Pulmonary Vascular
Impedance: Development of
New Techniques to Assess Right
Ventricular Afterload in Pulmonary
Arterial Hypertension
Ann Boyer, MD
The Jules Amer Continuity Practice
Award
Audrey C. Brumback, PhD
Mentor: Kevin J. Staley, MD
Joseph W. St. Geme Medical
Student Award
Jesse Davidson, MD,
Catherine Ferguson, MD,
Cameron Gunville, DO,
Jennifer McGuire, MD, and
Amy Shriver, MD
Outstanding Service in Medical
Student Teaching
2006-2008 Departmental Report
155
awards and honors
Catherine Ferguson, MD
Bruce Garber Memorial Award for
Outstanding Senior Resident
Margaret Ferguson, MD
C. Henry Kempe Award for
Outstanding Clinical Teacher
David Fox, MD
The Gary Way Award for
Outstanding Teaching
Jason Gien, MD
The L. Joseph and Perry Butterfield
Award in Perinatal Pediatrics
Mary P. GlodГ©, MD
Special Recognition Award for
Outstanding Dedication and
Service, Residency Recruitment
Selection Committee
Jessica Goodman, MD
Best Third-Year Fellow Poster
Award: Phactr 4 is a Tumor
Suppressor Gene
Amelia Hopkins, MD
Outstanding Fellow Teaching
Award, Critical Care
Karen Kelminson, MD
Pediatric Emergency Medicine
Award
Daniel Searing, MD
Joseph W. St. Geme, Jr., MD, Award
for Outstanding Research by a
Resident
Roopa Thukaram, MD
Best First-Year Fellow Poster Award:
Signaling Pathways Controlling
Gene Expression in Vascular Smooth
Muscle Cells
Department of Pediatrics
Teaching Awards 2007-2008
Leigh Anne Bakel, MD,
Carey Campbell, MD, MPH,
Scott Canna, MD,
Tracy Funk, MD,
Adam Green, MD,
Christine Jelinek, MD ,
Ashley Jones, MD,
Carrie Jones, MD,
Kristi Knuti, MD,
Ted Laetsch, MD,
Michelle Mills, MD,
Sarah Morse, MD,
Kirsten Nelson, MD,
Emily Showman, MD,
Amy Shriver, MD,
Jon Silverman, MD,
Emily Todd, MD, and
Meghan Treitz, MD
Outstanding Service in Medical
Student Teaching
Christopher Baker, MD
Best Third-Year Fellow Poster
Award: Oxidative Stress Decreases
the In Vitro Growth Potential of
Umbilical Cord Blood-Derived
Endothelial Progenitor Cells (EPCs)
from Preterm Neonates
David Brumbaugh, MD
Outstanding Fellow Teaching
Award, Gastroenterology
Christina Seng Chao, PhD
Mentor: Lori Sussel, PhD
Joseph W. St. Geme Medical
Student Award
Marc Chester, MD
Best Second-Year Fellow Poster
Award: BAY 58-2667, a Soluble
Guanylate Cyclase (sGC) Activator,
Causes Potent and Sustained in the
Ovine Fetus
Julia Fuzak, MD
Best First-Year Fellow Poster Award:
Characterization of End-Tidal
CO2 Waveforms During Effective
Endotracheal Intubation, Bag-ValveMask, and Laryngeal Mask Airway
Ventilation
Lia Gore, MD
Special Recognition Award for
Outstanding Dedication and
Service, Residency Recruitment
Selection Committee
Danna Gunderson, MD
The Jules Amer Continuity Practice
Award
Beena Kamath, MD
The L. Joseph and Perry Butterfield
Award in Perinatal Pediatrics
Colorado Pediatric
Stroke Program
Awards and Honors are listed in
Child Neurology and Hematology,
Oncology and BMT.
Colorado WIN Partners
Judith L. Emery, MA, has been
selected as a Board Member of
the Denver Workforce Investment
Board (2008-present); Panel
Member of Experts, Colorado
Association for Career and Technical
Administrators Conference (2008);
Content Expert, Civil Rights
Section, www.DisabilityInfo.gov
Web Site, Association of University
Centers on Disabilities (2008);
Denver Youth Council Member
(2008-present); Arapahoe/Douglas
Works! Workforce Investment
Board (2007-present); Specialized
Services Award, Colorado Chapter
of the International Association
of Workforce Professionals, Video
Training on the Disability Program
Navigator Program (2007).
Patrick E. Loeber, BS, received
the Specialized Services Award
by the Colorado Chapter of the
International Association of
Workforce Professionals, Video
Training on the Disability Program
Navigator Program (2007).
Peter J. Pike, BA, was selected
to be panel expert for Aurora
Town Hall Meeting hosted by
State Representative Morgan
Carroll on “Transitioning Youth
with Disabilities to the Work
Force” (2007); Specialized Services
Award, Colorado Chapter of
the International Association of
Workforce Professionals, Video
Training on the Disability Program
Navigator Program (2007).
Gastrointestinal
Eosinophil Center
Awards and Honors are listed in each
investigator’s section/program.
Intellectual and Developmental
Disabilities Research Center
William R. Betts, PhD, is President
of the Colorado Psychological
Association (2008-2009).
Awards and Honors are listed in each
investigator’s section/program.
Yvonne Kellar-Guenther, PhD,
is a President’s Teaching Learning
Collaborative Member, UCD (2008).
JFK Partners
Marilyn Krajicek, RN, EdD, FAAN,
received the American Journal of
Nursing Book of the Year Award for
“Nursing Excellence for Children and
Families” (2006).
Kristi Knuti, MD
Bruce Garber Memorial Award for
Outstanding Senior Resident
Ted Laetsch, MD
Joseph W. St. Geme, Jr., MD, Award
for Outstanding Research by a
Resident
Michael Mitchell, MD
Pediatric Emergency Medicine
Award
Julie Noffsinger, MD
The Gary Way Award for
Outstanding Teaching
Bruce Reddix, MD
C. Henry Kempe Award for
Outstanding Clinical Teacher
1 56 D e p a r t m e n t o f P e d i a t r i c s
Career Teaching Scholars Awardees, Stephen Berman, MD,
and Michael Kappy, MD, PhD, (middle and right), with
Stephen Daniels, MD, PhD, (left)
awards and honors
Mary Jane Rapport, PhD, PT,
received the Lucy Blair Service
Award from the American Physical
Therapy Association (2008).
Judy Reaven, PhD, received
Recognition and Contribution to the
Autism Community Award from the
Organization for Autism Research
(2006); Dane G. Prugh Award for
Outstanding and Inspirational
Teaching in Child Psychiatry,
Department of Psychiatry, UCD
(2007).
Cheryl Rooke, MA, CCC-SLP,
received the Award for Outstanding
Achievement in Continuing
Education, American SpeechLanguage-Hearing Association
(2007).
Pediatric Heart Lung Center
Awards and Honors are listed in each
investigator’s section/program.
Perinatal Research Center
Awards and Honors are listed in each
investigator’s section/program.
TCH Clinical Translational
Research Center
The Colorado Clinical and
Translational Sciences Institute
(CCTSI) was funded for five years
by the NIH in May 2008, becoming
one of 38 Clinical and Translational
Science Awardees (CTSA) in the U.S.
Ronald J. Sokol, MD, Section Head
of Gastroenterology, Hepatology
and Nutrition in the Department
of Pediatrics, is the Principal
Investigator and Director of the
CCTSI.
Additional Awards and Honors are
listed in each investigator’s section/
program.
The Children’s Hospital
Research Institute
Awards and Honors are listed in each
investigator’s section/program.
The Children’s Hospital
Sleep Center
Awards and Honors are listed under
Pulmonology and Developmental
and Behavioral Pediatrics.
affiliates
Barbara Davis Center for
Childhood Diabetes
Jennifer M. Barker, MD, received
the Journal of Clinical Endocrinology
& Metabolism Outstanding Reviewer
Recognition Award (2007).
George S. Eisenbarth, MD, PhD,
received the Banting Medal for
Scientific Achievement by the
American Diabetes Association
(2009); Donald F. Steiner Award for
Outstanding Diabetes Research,
University of Chicago (2008);
Pasteur-Weizmann/ Servier
International Prize and Tribute
(2006); Dean’s Mentoring Award,
Graduate School, UCDSOM (2006);
Louis Izenstein Visiting Professor
at Baystate Medical Center,
Massachusetts (2007); Invited
Visiting Professor, Vanderbilt
University (2008), University of
California San Francisco (2008),
Children’s Hospital of Oakland,
California (2008), and the
NIH (2008); President, Clinical
Immunology Society (2006-2007);
Co-Chair, Autoimmunity Immune
Tolerance Network (2000-present);
Section Editor, Journal of Clinical
Investigation (2003-2007); Section
Editor, Current Diabetes Reports
(2000-present); Consulting Editor,
Journal of Clinical Investigation
(2000-present); Editor, Journal of
Clinical Endocrinology & Metabolism
(2005-present); Editorial Board,
Journal of the American Diabetes
Association (2008-present); Board
Member, Juvenile Diabetes
Research Foundation Research
Portfolio Advisory Committee
(2005-2007); Scientific Advisory
Board, Macrogenics (Type 1
Diabetes) (2005-2007); Scientific
Advisory Board, Bayhill
Therapeutics (Type 1 Diabetes)
(2003-present); Board Member,
Dean’s Distinguished Committee,
UCDSOM (2008-present).
Satish K. Garg, MD, is Editorin-Chief of Diabetes Technology
and Therapeutics (2006-present);
Invited Speaker, Research Society
for the Study of Diabetes, India:
“Emerging Technologies in the Field
of Diabetes in the 21st Century”
(2007); Chair, Clinical Therapeutics
for Scientific Sessions, American
Diabetes Association (2007-2008);
Guest Editor-in-Chief, Diabetes
Obesity and Metabolism Journal
Supplement Issue: Long-Acting Insulin
Analogs (2008).
Paritosh Kaul, MD, is Director
of the Cultural Competency and
Diversity Thread, Office of the Dean
of Curriculum, UCDSOM (2007);
Medical Course Director, Hot Topics
in Adolescent Medicine, Rocky
Mountain Chapter for the Society
for Adolescent Medicine (2007);
Secretary, Colorado Chapter, AAP
(2005-2008); Received Proclamation,
In Salute of Paritosh Kaul, MD, for
Service to Adolescent Medicine, City
and County of Denver, Proclamation
20 Series of 2007 (2007).
Georgeanna J. Klingensmith,
MD, is listed among America’s Best
Physicians (1993-2007).
Kathryn A. Love-Osborne, MD,
was appointed to the Society for
Adolescent Medicine Program
Planning Committee (2007-2009).
R. Paul Wadwa, MD, is President
of the Leadership Board for the
Colorado Chapter of the American
Diabetes Association (2008).
Denver Health
Mark E. Anderson, MD, is Director
of the Rocky Mountain Region
Pediatric Environmental Health
Specialty Unit (2002-present);
Keynote Speaker, Tribal Nations
Children’s Environmental Health
Summit, Denver (2007).
Patricia A. Braun, MD, was selected to join the Cavity Free at Three
Technical Assistance Team, Caring
for Colorado (2008-2011).
Steven G. Federico, MD, was
awarded a Physician Advocacy
Fellowship by the Institute on
Medicine as a Profession (20062008); Governor’s Early Childhood
Council /P-3 Subcommittee
Member (2007); Governor’s Advisory
Committee, Covering All Children in
Colorado (2007).
Simon J. Hambidge, MD, PhD,
is listed in Best Doctors in America
(2007-2008); Colorado Medical
Home Initiative, Provider-Practice
Management Task Force and
Medical Home Advisory Board,
Colorado Department of Public
Health and Environment (2007);
National Scholars Award, Robert
Wood Johnson Foundation (20032007); Charles C. Shepard Science
Award, CDC Office of the Director
(2007).
Paul Melinkovich, MD, is PresidentElect of the Board of Directors,
National Assembly on SchoolBased Health Care (2006-present);
President, Denver Health Medical
Staff (2004-2006).
Mary E. O’Connor, MD, MPH, is
a Member of the Breastfeeding
Committee, Section of
Breastfeeding Medicine, Colorado
Chapter, AAP (2008).
John W. Ogle, MD, is a Consultant
to the Anti-Infective Drugs Advisory
Committee, FDA (2006-present); Board of Directors, NCCPA
Foundation (2006-present); 5280
Magazine’s Top Doctors in Denver
(2008).
Stephen D. Vogler, MD, received
the James Strain Community Service
Award, Colorado Chapter, AAP
(2008); Medical Director, Reach Out
and Read Colorado (1997-present).
Kathryn M. Wells, MD, FAAP,
was appointed to the Colorado
Child Welfare Action Committee
by the Governor (2008); National
Collaborative Leadership Award,
National Center on Substance
Abuse and Child Welfare, Center
for Substance Abuse and Mental
Health Services Administration
(2007); Commissioner’s Award, the
Administration on Children, Youth
and Families, HHS (2007); Hospital
Representative, Colorado State
Methamphetamine Task Force
(2006); Treasurer, Board of Directors,
Colorado Chapter, AAP (2007).
2006-2008 Departmental Report
157
awards and honors
National Jewish Health
F. Dan Atkins, MD, was named
Pediatric Clinician of the Year,
Department of Pediatrics, National
Jewish Health (2006); Best Doctors
in America (2003-2006); 5280
Magazine’s Top Doctors in Denver
(2006-present).
Mark Boguniewicz, MD, received
the Richard S. Farr Memorial
Lectureship, American Academy of
Allergy, Asthma and Immunology
(2006); Best Doctors in America
(2006-2008).
Kirstin D. Carel, MD, was named
Pediatric Clinician of the Year,
Department of Pediatrics, National
Jewish Health (2008).
David M. Fleischer, MD, is Vice
President of the Colorado Allergy
and Asthma Society (2008).
Erwin W. Gelfand, MD, is listed as
one of the Best Doctor’s in America
(2006-2008); Lifetime Achievement
Award, National Jewish Health
(2007); AAAAAI Honorary Fellowship
Award (2008); Science Transforming
Life Award, National Jewish Health
(2008).
Pia Hauk, MD, received the
National Jewish Clinician Scientist
Career Development Award (20062007); Natalie V. Zucker Award for
Women Scholars (2008).
Richard B. Johnston, Jr., MD, is
Chairman of the Committee on
Training of Physicians for Public
Health Careers, Institute of Medicine
of the National Academies of
Science (2006-2007); President’s
Award, National Jewish Health
(2007); John Howland Medal,
American Pediatric Society (2008);
Distinguished Alumnus Award,
Vanderbilt University School of
Medicine (2008).
Marzena E. Krawiec, MD, received
the Outstanding Teacher of the
Year Award, Pediatric Allergy and
Immunology Fellows, National
Jewish Health (2006-2007); Pediatric
Clinician of the Year, National
Jewish Health Faculty Award
(2006-2007).
Gary L. Larsen, MD, was listed
in 5280 Magazine’s Top Doctors
in Denver (2006); Best Doctor’s
in America (2006); America’s Top
Doctors (2006-2008).
Patient in front of The Children’s Hospital
1 58 D e p a r t m e n t o f P e d i a t r i c s
Donald Y.M. Leung, MD, PhD,
is one of the Most Highly Cited
Authors in Immunology, Institute
for Scientific Information (2006);
Outstanding Scientific Achievement
in Clinical Research Award, National
Jewish Health (2008).
Andrew H. Liu, MD, is a
Member of the Study Section in
Infectious Disease, Reproductive
Health, Asthma, and Pulmonary
Epidemiology, NIH (2006-2010); Best
Doctors in America (2005-present).
David P. Nichols, MD, received the
Leroy Matthews Physician Scientist
Award, Cystic Fibrosis Foundation
(2007); Award for Outstanding
Research and Award for
Outstanding Research Presentation,
Rainbow Babies & Children’s
Hospital All Fellows Research Day
(2007-2008).
Nathan Rabinovitch, MD, was
listed as one of the Best Doctor’s in
America (2007).
Stanley J. Szefler, MD, is a Member
of the Expert Panel-3 for the revision of the Guidelines for the
Diagnosis and Management of
Asthma, National Asthma Education
and Prevention Program, NHLBI,
NIH (2005-present); Program
Project Grant Reviewer, NHLBI,
NIH (2006-2008); Deputy Editor,
Journal of Allergy and Clinical
Immunology (1997-present);
Pediatric and Obstetrics Strategic
Plan Advisory Committee, NICHD
(2007); Study Section Member,
Clinical Trial Review Committee,
NHLBI (2008-present); Denver Public
Schools Health Research Review
Committee (2008-present); Editor,
Childhood Asthma: Breaking Down
the Barriers (2006).
Carl W. White, MD, is Director of
the Denver-based NIH CounterACT
(Countermeasures Against Chemical
Threats) Program (2006-present);
Visiting Professor in Pulmonology
(at University of California at Davis),
Pfizer (2007).
awards and honors
Reporting
2 0 0 6 – 2 0 0 8 DE PA R T M E N TA L R E P O R T
publications
Boettcher Atrium at The Children’s Hospital
2006-2008 Departmental Report
159
publications
sections
Adolescent Medicine
2008 Publications
Dunbar J, Sheeder J, Lezotte D,
Dabelea D, Stevens-Simon C. Age
at menarche and first pregnancy
among psychosocially at-risk adolescents. Am J Public Health. 2008
Oct;98(10):1822-4. [PMID: 18703451]
Fox HB, McManus MA, Diaz A,
Elster AB, Felice ME, Kaplan DW,
Klein JD, Wilson JE. Advancing
medical education training in
adolescent health. Pediatrics.
2008 May;121(5):1043-5. [PMID:
18450908]
Jumping-Eagle S, Sheeder J, Kelly LS,
Stevens-Simon C. Association of
conventional goals and perceptions
of pregnancy with female teenagers’ pregnancy avoidance behavior
and attitudes. Perspect Sex Reprod
Health. 2008 Jun;40(2):74-80. [PMID:
18577139]
Kabir K, Sheeder J, Kelly LS.
Identifying postpartum depression:
are 3 questions as good as 10?
Pediatrics. 2008 Sep;122(3):e696-702.
[PMID: 18762505]
Kaplan D. Clinical FusionВ®: Primary
HealthCare – ONLINE! Clinical
Management Information System
for Primary Care in School and
Community Based Programs.
Visual Basic Software [Internet].
Aurora (CO): University of Colorado
Denver, Department of Pediatrics;
2008. Available from: http://clinicalfusion.com
Kaplan DW, Love-Osborne K.
Adolescence. In: Hay WW Jr,
Levin MJ, Sondheimer JM,
Deterding RR, editors. Current
pediatric diagnosis and treatment.
19th ed. New York: McGraw-Hill;
2009.
Kaul P, Stevens-Simon C, Saproo A,
Coupey SM. Trends in illness
severity and length of stay in
inner-city adolescents hospitalized
for pelvic inflammatory disease.
J Pediatr Adolesc Gynecol. 2008
Oct;21(5):289-93. [PMID: 18794025]
Love-Osborne K, Sheeder J, Zeitler P.
Addition of metformin to a lifestyle
modification program in adolescents with insulin resistance.
J Pediatr. 2008 Jun;152(6):817-22.
[PMID: 18492523]
Love-Osborne KA, Nadeau KJ,
Sheeder J, Fenton LZ, Zeitler P.
Presence of the metabolic
syndrome in obese adolescents
predicts impaired glucose tolerance and nonalcoholic fatty liver
disease. J Adolesc Health. 2008
Jun;42(6):543-8. [PMID: 18486862]
Nyquist AC, Levin MJ, Sigel EJ.
Sexually transmitted infections.
In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric diagnosis
and treatment. 19th ed. New York:
McGraw-Hill; 2009.
Reirden DH, Pletcher J.
Contraception. In: Schwartz MW,
Bell LM, Bingham P, Chung EK,
Friedman D, Mulburg A, Schwartz C,
Tanel R, editors. The 5-minute pediatric consult. 5th ed. Philadelphia:
Lippincott William & Wilkins, 2008.
Reirden DH, Pletcher J. Pelvic
inflammatory disease. In:
Schwartz MW, Bell LM, Bingham P,
Chung EK, Friedman D, Mulburg A,
Schwartz C, Tanel R, editors. The
5-minute pediatric consult. 5th ed.
Philadelphia: Lippincott William &
Wilkins; 2008.
Reirden DH, Pletcher J, Ginsburg KR.
Pubertal delay. In: Schwartz MW,
Bell LM, Bingham P, Chung EK,
Friedman D, Mulburg A, Schwartz C,
Tanel R, editors. The 5-minute pediatric consult. 5th ed. Philadelphia:
Lippincott William & Wilkins; 2008.
Sigel EJ. Eating disorders.
In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric diagnosis
and treatment. 19th ed. New York:
McGraw Hill; 2009.
2007 Publications
Hall DA, Sheeder J, Box T,
Shroyer AL. Clinical science training
at the University of Colorado: a
measurement of trainee satisfaction.
J Investig Med. 2007 May;55(4):
181-6. [PMID: 17651672]
Jumping-Eagle S, Sheeder J, Kelly LS,
Stevens-Simon C. Feasibility and
utility of screening adolescent
mothers for chlamydia at their
children’s health care visits. Matern
Child Health J. 2007 Nov;11(6):
586-94. [PMID: 17549616]
1 60 D e p a r t m e n t o f P e d i a t r i c s
Kahn MG, Kaplan D, Sokol RJ,
DiLaura RP. Configuration challenges: implementing translational research policies in electronic
medical records. Acad Med. 2007
Jul;82(7):661-9. [PMID: 17595562]
Kaplan DW, Love-Osborne K.
Adolescence. In: Hay WW Jr,
Levin MJ, Sondheimer JM,
Deterding RR, editors. Current
pediatric diagnosis and treatment.
18th ed. New York: McGraw Hill;
2007.
Kaul P, Kaplan DW. Caring for
adolescents in the office. In:
Greydanus DE, Patel DR, Pratt HD,
editors. Essential adolescent.
New York: McGraw-Hill; 2007.
Kaul P, Stevens-Simons C. Substance
abuse. In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric diagnosis
and treatment. 18th ed. New York:
McGraw Hill; 2007.
Kinsella EO, Crane LA, Ogden LG,
Stevens-Simon C. Characteristics
of adolescent women who stop
using contraception after use at
first sexual intercourse. J Pediatr
Adolesc Gynecol. 2007 Apr;20(2):
73-81. [PMID: 17418390]
Nyquist, AC, Sigel EJ, Levin, MH.
Sexually transmitted infections.
In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric diagnosis
and treatment. 18th ed. New York:
McGraw Hill; 2007.
Reirden DH, Schwarz DF. Eating
disorders. In: Zaoutis LB, Chiang VW.
Comprehensive pediatric hospital
medicine. St. Louis: Mosby; 2007.
Sigel EJ. Eating disorders.
In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric diagnosis
and treatment. 18th ed. New York:
McGraw-Hill; 2007.
Stamm C, Kabir K, McGregor J.
Advances in the care and prevention of sexually transmitted infections in adolescent women. Patient
Care. 2007 Jul;41(16):6-16.
Stevens-Simon C. Elusive denominators and the illusions they create.
J Adolesc Health. 2007 Sep;41(3):
315; Author reply 315-6. [PMID:
17707304]
2006 Publications
Gray S, Sheeder J, O’Brien R,
Stevens-Simon C. Having the best
intentions is necessary but not
sufficient: what would increase
the efficacy of home visiting for
preventing second teen pregnancies? Prev Sci. 2006 Dec;7(4):389-95.
[PMID: 16909322]
Sheeder J, Lezotte D,
Stevens-Simon C. Maternal age
and the size of White, Black,
Hispanic, and mixed infants.
J Pediatr Adolesc Gynecol. 2006
Dec;19(6):385-9. [PMID: 17174827]
Sheeder J, Stevens-Simon C,
Lezotte D, Glazner J, Scott S.
Cervicitis: to treat or not to treat?
The role of patient preferences and
decision analysis. J Adolesc Health.
2006 Dec;39(6):887-92. [PMID:
17116520]
Sigel EJ. Conduct disorder, aggression, and violence in adolescents.
In: Burg FD, Inglefinger JR, Polin RA,
Gershon AA, editors. Gellis and
Kagan’s current pediatric therapy.
18th ed. Philadelphia: WB Saunders;
2006.
Stevens-Simon C. Assent in
pediatric research. Pediatrics. 2006
Oct;118(4):1800-1. Author reply
1801. [PMID: 17015581]
Stevens-Simon C. Management
quandary. Teen pregnancy and
sexually transmitted diseases:
re-thinking the bedfellow question
means that condoms will never be
seatbelts. J Pediatr Adolesc Gynecol.
2006 Oct;19(5):351-2. [PMID:
17060020]
Allergy, Immunology and
Rheumatology*
2008 Publications
Soep JB, Hollister JR. Illnesses:
rheumatologic diseases. In: Haith M,
Benson J, editors. Encyclopedia of
infant and early childhood development. St. Louis: Elsevier/Academic
Press; 2008.
Soep JB, Hollister JR. Rheumatic
diseases. In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric diagnosis
and treatment. 19th ed. New York:
McGraw-Hill; 2009.
publications
Soep JB, Wagener JS, Hollister JR,
Hay TC. Collagen vascular disorders.
In: Taussig LM, Landau LI, editors.
Pediatric respiratory medicine. 2nd
ed. St. Louis: Mosby/Elsevier; 2008.
2007 Publications
Balachandran P, Dragone LL,
Garrity-Ryan L, Weiss A, Engel J.
The ubiquitin ligase Cbl-b limits
Pseudomonas aeruginosa exotoxin
T-mediated virulence. J Clin Invest.
2007 Feb 1;117(2):419-27. [PMID:
17235393]
Hollister JR. Rheumatic diseases.
In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric diagnosis
and treatment. 18th ed. New York:
McGraw Hill; 2007.
2006 Publications
Dragone LL, Myers MD, White C,
Gadwal S, Weiss A. Src-Like adaptor protein (SLAP), regulates B cell
receptor levels in a c-Cbl-dependent
manner. Proc Natl Acad Sci USA.
2006 Nov 28;103(48):18202-7.
[PMID: 17110436]
Myers MD, Sosinowski T, Dragone LL,
White C, Band H, Gu H, Weiss A.
Src-like adaptor protein regulates
TCR expression on thymocytes by
adapting c-Cb l to the TCR complex.
Nat Immunol. 2006 Jan;7(1):57-66.
[PMID: 16327786]
*Dr. Erwin Gelfand’s publications are
listed under National Jewish Health.
Cardiology
2008 Publications
Amin R, Anthony L, Somers V,
Fenchel M, McConnell K,
Jefferies J, Willging P, Kalra M,
Daniels S. Growth velocity predicts
recurrence of sleep-disordered
breathing 1 year after adenotonsillectomy. Am J Respir Crit Care
Med. 2008 Mar;177(6):654-9. [PMID:
18174542]
Amin R, Somers VK, McConnell K,
Willging P, Myer C, Sherman M,
McPhail G, Morgenthal A, Fenchel M,
Bean J, Kimball T, Daniels S. Activityadjusted 24-hour ambulatory blood
pressure and cardiac remodeling
in children with sleep disordered
breathing. Hypertension. 2008
Jan;51(1):84-91. [PMID: 18071053]
Berul CI, Van Hare GF, Kertesz NJ,
Dubin AM, Cecchin F, Collins KK,
Cannon BC, Alexander ME,
Triedman JK, Walsh EP, Friedman RA.
Results of a multicenter retrospective implantable cardioverterdefibrillator registry of pediatric
and congenital heart disease
patients. J Am Coll Cardiol. 2008
Apr;51(17):1685-91. [PMID:
18436121]
Bhogal N, Grady AM, Ursell PC,
Collins KK, Hornberger LK.
Hypersensitivity myocarditis presenting as atrioventricular block
and wide complex tachycardia in a
toddler. Congenit Heart Dis. 2008
Sep;3(5):359-64. [PMID: 18837817]
Boucek MM, Mashburn C, Dunn SM,
Frizell R, Edwards L, Pietra B,
Campbell D. Pediatric heart transplantation after declaration of
cardiocirculatory death. N Engl
J Med. 2008 Aug;359(7):709-14.
[PMID: 18703473]
Chanani NK, Chiesa NA, Dubin AM,
Avasarala K, Van Hare GF, Collins KK.
Cryoablation for atrioventricular
nodal reentrant tachycardia in
young patients: predictors of recurrence. Pacing Clin Electrophysiol.
2008 Sep;31(9):1152-9. [PMID:
18834467]
Chhatriwalla AK, Prieto LR,
Brunken RC, Cerqueira MD,
Younoszai A, Jaber WA. Preliminary
data on the diagnostic accuracy
of rubidium-82 cardiac PET perfusion imaging for the evaluation of
ischemia in a pediatric population.
Pediatr Cardiol. 2008 Jul;29(4):732-8.
[PMID: 18458995]
Cikirikcioglu M, Pektok E,
Cikirikcioglu BY, Osorio-da Cruz S,
Tille JC, Kalangos A, Walpoth BW.
Matching the diameter of ePTFE
bypass prosthesis with a native
artery improves neo-endothelisalВ­
isation. Eur Surg Res. 2008;40(4):
333-40. [PMID: 18303269]
Collins KK. Another tool for the
ablation toolbox. J Cardiovasc
Electrophysiol. 2008 Feb;19(2):
194-6. [PMID: 18031514]
Collins KK, Sondheimer JM.
Domperidone-induced QT prolongation: add another drug to the
list. J Peds. 2008 Nov;153(5):596-8.
[PMID: 18940349]
Couch SC, Saelens BE, Levin L,
Dart K, Falciglia G, Daniels SR. The
efficacy of a clinic-based behavioral
nutrition intervention emphasizing
a DASH-type diet for adolescents
with elevated blood pressure.
J Pediatr. 2008 Apr;152(4):494-501.
[PMID: 18346503]
Doran AK, Ivy DD, Barst RJ, Hill N,
Murali S, Benza RL. Guidelines for
the prevention of central venous
catheter-related blood stream infections with prostanoid therapy for
pulmonary arterial hypertension.
Int J Clin Pract Suppl. 2008
Jul;(160):5-9. [PMID: 18638170]
da Cruz EM, Beghetti M, Kalangos A,
Berner M, Sierra J, Aggoun Y, Tissot C,
Pellegrini M, Saudan S, Habre W,
Rimensberger PC. Mechanical
support availability in pediatric cardiac surgery: program size should
not matter. Int J Cardiol. 2008
Sep:129(2):282-4. [PMID: 17689727]
Franko DL, Striegel-Moore RH,
Thompson D, Affenito SG,
Schreiber GB, Daniels SR,
Crawford PB. The relationship
between meal frequency and
body mass index in black and
white adolescent girls: more is
less. Int J Obes (Lond). 2008
Jan;32(1):23-9. [PMID: 17563764]
Daniels SR. Ambulatory blood pressure and cardiac abnormalities.
J Pediatr. 2008 Mar;152(3):A2.
[PMID: 18280820]
Daniels SR. Do we have enough
pediatric endocrinologists?
J Pediatr. 2008 Mar;152(3):A2.
[PMID: 18280821]
Daniels SR. Growth hormone and
fat distribution in SGA children.
J Pediatr. 2008 Mar;152(3):A3.
[PMID: 18280824]
Daniels SR. Quality of life after surgery for congenital heart disease.
J Pediatr. 2008 Mar;152(3):A3.
[PMID: 18280827]
Daniels SR. Screening for familial
hypercholesterolemia: what is
the most effective strategy? Nat
Clin Pract Cardiovasc Med. 2008
Mar;5(3):130-1. [PMID: 18059381]
Daniels SR, Greer FR. Lipid
screening and cardiovascular
health in childhood. Pediatrics.
2008 Jul;122(1):198-208. [PMID:
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Di Maria MV, Campbell DN,
Mitchell MB, Lovell MA, Pietra BA,
Miyamoto SD. Successful orthotopic
heart transplant in an infant with an
inflammatory myofibroblastic tumor
of the left ventricle. J Heart Lung
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Dominguez SR, Friedman K,
Seewald R, Anderson MS, Willis L,
GlodГ© MP. Kawasaki disease in
a pediatric intensive care unit:
a case-control study. Pediatrics.
2008 Oct;122(4):e786-90. [PMID:
18809597]
Goldberg SP, Mitchell MB,
Campbell DN, Tissot C,
Lacour-Gayet F. Anomalous left
coronary artery from the pulmonary
artery with an intramural course
within the aortic wall: report of
3 surgical cases. J Thorac Cardiovasc
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[PMID: 18329500]
Hornberger LK, Collins K. New
insights into fetal atrioventricular
block using fetal magnetocardiography. J Am Coll Cardiol. 2008
Jan;51(1):85-6. [PMID: 18174042]
Hunter KS, Gross JK, Lanning CJ,
Kirby KS, Dyer KL, Ivy DD, Shandas R.
Noninvasive methods for determining pulmonary vascular function
in children with pulmonary arterial
hypertension: application of a
mechanical oscillator model.
Congenit Heart Dis. 2008 Mar;3(2):
106-16. [PMID: 18380759]
Hunter KS, Lee PF, Lanning CJ,
Ivy DD, Kirby KS, Claussen LR,
Chan KC, Shandas R. Pulmonary
vascular input impedance is a
combined measure of pulmonary
vascular resistance and stiffness
and predicts clinical outcomes better than pulmonary vascular resistance alone in pediatric patients
with pulmonary hypertension.
Am Heart J. 2008 Jan;155(1):166-74.
[PMID: 18082509]
Ippisch HM, Inge TH, Daniels SR,
Wang B, Khoury PR, Witt SA,
Glascock BJ, Garcia VF, Kimball TR.
Reversibility of cardiac abnormalities in morbidly obese adolescents.
J Am Coll Cardiol. 2008 Apr;51(14):
1342-8. [PMID: 18387434]
2006-2008 Departmental Report
161
publications
Ivy DD, Doran AK, Smith KJ,
Mallory GB Jr, Beghetti M, Barst RJ,
Brady D, Law Y, Parker D, Claussen
L, Abman SH. Short- and long-term
effects of inhaled iloprost therapy
in children with pulmonary arterial
hypertension. J Am Coll Cardiol.
2008 Jan 15;51(2):161-9. [PMID:
18191742]
Karam O, da Cruz E,
Rimensberger PC. VGAM induced
high-flow congestive heart failure
responsive to PGE(1) infusion.
Int J Cardiol. 2009 Feb 20;132(2):
e60-2. [PMID: 18022260]
Kramer RE, Daniels S. Special issues
in treatment of pediatric obesity.
In: Bray GA, Bouchard C, editors.
Handbook of obesity. 3rd ed.
New York: Marcel Dekker Inc; 2008.
Lammers SR, Kao P, Qi HJ, Hunter K,
Lanning C, Albietz J, Hofmeister S,
Mecham RP, Stenmark KR,
Shandas R. Changes in the structurefunction relationship of elastin and
its impact on the proximal pulmonary arterial mechanics of hypertensive calves. Am J Physiol Heart Circ
Physiol. 2008 Oct;295(4):H1451-9.
[PMID: 18660454]
Liu L, Zheng H, Williams L, Zhang F,
Wang R, Hertzberg J, Shandas R.
Development of a custom-designed
echo particle image velocimetry
system for multi-component
hemodynamic measurements:
system characterization and initial
experimental results. Phys Med Biol.
2008 Mar;53(5):1397-412. [PMID:
18296769]
Malhotra SP, Ivy DD, Mitchell MB,
Campbell DN, Dines ML, Miyamoto S,
Kay J, Clarke DR, Lacour-Gayet F.
Performance of cavopulmonary
palliation at elevated altitude: midterm outcomes and risk factors for
failure. Circulation. 2008 Sep;118(14
Suppl):S177-81. [PMID: 18824752]
Malhotra SP, Lacour-Gayet F,
Campbell DN, Miyamoto S, Clarke DR,
Dines ML, Ivy DD, Mitchell MB.
Outcomes of reparative and transplantation strategies for multilevel
left heart obstructions with mitral
stenosis. Ann Thorac Surg. 2008
Oct;86(4):1305-9. [PMID: 18805182]
McCanta AC, Chang AC, Weiner K.
Cardiomyopathy in a child with
neutropenia and motor delay. Curr
Opin Pediatr. 2008 Oct;20(5):605-7.
[PMID: 18781126]
Morchi GS, Pietra B, Boucek MM,
Chan KC. Interventional cardiac
catheterization procedures in pediatric cardiac transplant patients:
Transplant surgery is not the end
of the road. Catheter Cardiovasc
Interv. 2008 Nov;72(6):831-6.
[PMID: 18798241]
Mourani PM, Ivy DD, Rosenberg AA,
Fagan TE, Abman SH. Left ventricular diastolic dysfunction in bronchopulmonary dysplasia. J Pediatr.
2008 Feb;152(2):291-3. [PMID:
18206706]
Mourani PM, Sontag MK,
Younoszai A, Ivy DD, Abman SH.
Clinical utility of echocardiography
for the diagnosis and management
of pulmonary vascular disease
in young children with chronic
lung disease. Pediatrics. 2008
Feb;121(2):317-25. [PMID: 18245423]
Phelps CM, Mengshol S, Ivy DD.
A curious isolated cystic lesion of
the membranous atrioventricular septum. Cardiol Young. 2008
Dec;18(6):631-4. [PMID: 18950547]
Silva IA, da Cruz EA. The work of the
intensive care nurse: a study on the
social representations structure.
Rev Esc Enferm USP. 2008 Sep;42(3):
554-62. [PMID: 18856125]
Sondheimer HM, Darst JR,
Shaffer, EM, Miyamoto SD.
Cardiovascular diseases. In:
Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric diagnosis
and treatment. 19th ed. New York:
McGraw Hill; 2009.
Sun SS, Liang R, Huang TT,
Daniels SR, Arslanian S, Liu K,
Grave GD, Siervogel RM.
Childhood obesity predicts adult
metabolic syndrome: the Fels
Longitudinal Study. J Pediatr.
2008 Feb;152(2):191-200. [PMID:
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Tissot C, Corbelli R, Aggoun Y,
Beghetti M, da Cruz E.
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atresia in an infant. Pediatr Cardiol.
2008 Sep;29(5):976-9. [PMID:
18026778]
Tissot C, Darst JR, Kaza AK,
Younoszai AK, da Cruz E. Partial left
pulmonary artery sling associated
with multiple ventricular septal
defects: a rare congenital anomaly.
J Thorac Cardiovasc Surg. 2008
Oct;136(4):1085-7. [PMID: 18954657]
Van Hove JL, Freehauf C,
Miyamoto S, Vladutiu GD,
Pancrudo J, Bonilla E, Lovell MA,
Mierau GW, Thomas JA, Shanske S.
Infantile cardiomyopathy caused by
the T14709C mutation in the mitochondrial tRNA glutamic acid gene.
Eur J Pediatr. 2008 Jul;167(7):771-6.
[PMID: 17891417]
Villavicencio K, Ivy D, Cole L, Nuss R.
Symptomatic pulmonary hypertension in a child with sickle cell disease. J Pediatr. 2008 Jun;152(6):
879-81. [PMID: 18492535]
Willis L, Wymore E, Thureen P,
Kaufman J, Skillman H, da Cruz E.
Enteral feeding in prostaglandindependent neonates: is it a safe
practice? J Pediatr. 2008 Dec;153(6):
867-9. [PMID: 19014824]
Yakacki CM, Lyons MB, Rech B,
Gall K, Shandas R. Cytotoxicity and
thermomechanical behavior of
biomedical shape-memory polymer
networks post-sterilization. Biomed
Mater. 2008 Mar;3(1):15010. [PMID:
18458497]
Yeung E, Kay J, Roosevelt GE,
Brandon M, Yetman AT. Lapse of
care as a predictor for morbidity in
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Int J Cardiol. 2008 Mar 28;125(1):
62-5. [PMID: 17442438]
Younoszai AK, Saudek DE, Emery SP,
Thomas JD. Evaluation of myocardial mechanics in the fetus by
velocity vector imaging. J Am Soc
Echocardiogr. 2008 May;21(5):
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2007 Publications
Affenito SG, Thompson DR,
Franko DL, Striegel-Moore RH,
Daniels SR, Barton BA, Schreiber GB,
Schmidt M, Crawford PB.
Longitudinal assessment of
micronutrient intake among
African American and white girls:
the National Heart, Lung, and Blood
Institute Growth and Health Study.
J Am Diet Assoc. 2007;107(7):
1113-23. [PMID: 17604740]
Barst R, Berman-Rosenzweig E,
Horn E, Saiman L, Lee L,
Southwick K, Kohlerschmidt D,
Smith P, Gomberg-Maitland M,
Weber S, Ivy D, Doran A, McGoon M,
Severson C, Rubenfire M,
McLaughlin V, Feldman, J, Tanner C,
Chin K, Kingman M. Bloodstream
infections among patients treated
with intravenous epoprostenol or
intravenous treprostinil for pulmonary arterial hypertension – seven
sites, United States, 2003-2006.
MMWR. 2007;56(8):170-72. [PMID:
17332729]
Tan W, Scott D, Belchenko D, Qi J,
Xiao L. Development and evaluation of microdevices for studying
anisotropic biaxial cyclic stretch on
cells. Biomed Microdevices. 2008
Dec;10(6):869-82. [PMID: 18563571]
Tissieres P, da Cruz E, Habre W,
Aggoun Y, Mensi N, Kalangos A,
Beghetti M. Value of brain natriuretic peptide in the perioperative
follow-up of children with valvular
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Jun;34(6):1109-13. [PMID: 18283430]
1 62 D e p a r t m e n t o f P e d i a t r i c s
Clint Hurdle, former manager of the Colorado Rockies, volunteers at
The Children’s Hospital
publications
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McCabe M, MacLeod K, Daniels S,
Amin R. Sleep in overweight
adolescents: shorter sleep, poorer
sleep quality, sleepiness, and sleepdisordered breathing. J Pediatr
Psychol. 2007;32(1):69-79. [PMID:
16467311]
Beghetti M, Doran AK, Mallory G,
Barst RJ, Law Y, Abman SH, Ivy DD.
Inhaled iloprost therapy in children
with pulmonary arterial hypertension. Cardiol Young. 2007;17(1):78.
Beghetti M, Haworth SG, Barst RJ,
Jais X, Acar P, Fraisse A, Ivy DD,
Schulze-Neick I, Bonnet D,
Berger RMF. Pharmacokinetics
and safety profile of a novel formulation of bosentan in children with
pulmonary arterial hypertension
(PAH): FUTURE-1 study. Eur Heart J.
2007;28(Suppl 1):150.
Buckvold S, Tissot-Daguette C,
Phelps CM, Mitchell MB,
Campbell DN, Ivy DD, Pietra BA,
Miyamoto SD. Primary heart transplantation for hypoplastic left heart
syndrome: effect of waiting time on
pulmonary artery pressure. Pediatr
Crit Care Med. 2007;8(3):A242.
Carmosino MJ, Friesen RH, Doran A,
Ivy DD. Perioperative complications
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surgery or cardiac catheterization.
Anes Anal. 2007;104(3):521-7. [PMID:
17312201]
Collins KK, Rhee EK, Kirsh JA,
Cannon BC, Fish FA, Dubin AM,
Van Hare GF. Pediatric and congenital electrophysiology society’s
working group on cryoablation.
Cryoablation of accessory pathways
in the coronary sinus in young
patients: a multicenter study
from the Pediatric and Congenital
Electrophysiology Society’s
Working Group on Cryoablation.
J Cardiovasc Electrophysiol. 2007
Jun;18(6):592-7. [PMID: 17472717]
da Cruz E, Aggoun Y, Tissot C,
Beghetti M. Appealing systematic
left-sided pacing leads for cardiac
resynchronization as therapy for
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2007;17:234-5. [PMID: 17291395]
da Cruz E, Billieux MH, Beghetti MA.
New insights into fetal atrioventricular block and pulmonary valvar
stenosis. Int J Cardiol. 2007;116:
e13-e4.
da Cruz E, Billieux, MH, Beghetti, M.
A neonate with isolated combined
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Int J Cardiol. 2007 Mar;116(1):e13-4.
[PMID: 17095108]
da Cruz E, Tissot C. Role of magnetic
resonance with delayed contrast
enhancement imaging in the diagnosis of congenital ventricular
outpouching. Eur Heart J. 2007;28:
1040-1.
Daniels SR, Long B, Crow S, Styne D,
Sothern M, Vargas-Rodriguez L,
Harris L, Walch J, Jasinsky O, Cwik K,
Hewkin A, Blakesley V; for the
Sibutramine Adolescent Study
Group. Cardiovascular effects
of sibutramine in the treatment
of obese adolescents: results
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2007;120:e147-e57. [PMID:
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Darst JR, Kaufman J. Case report:
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ectopic tachycardia requiring extracorporeal mechanical oxygenation.
Curr Opin Pediatr. 2007;19:597-600.
[PMID: 17885482]
DeBiasi RL, Robinson BA,
Miyamoto SD, Smoak K, Sherry B,
Long CS, Tyler KL. Apoptotic
signaling in viral myocarditis:
potential therapeutic target.
Infectious Disease Society of
America 45th Annual Meeting,
October 4-7; San Diego; 2007.
Drexler ES, Quinn TP, Slifka AJ,
McCowan CN, Bischoff JE,
Wright JE, Ivy DD, Shandas R.
Comparison of mechanical behavior among the extrapulmonary
arteries from rats. J Biomech Eng.
2007;40(4):812-19. [PMID: 16682044]
Goodman E, Daniels SR, Dolan, LM.
Socioeconomic disparities in insulin resistance: Results from the
Princeton School District Study.
Psychosom Med. 2007;69:61-7.
[PMID: 17167128]
HoudГ© C, Toledano B, da Cruz E,
Toledano B, Vobecky S, Lacroix J.
Soins post-opГ©ratoires en chirurgie
cardiaque pГ©diatrique. In: Lacroix J,
Gauthier M, Hubert P, Leclerc F,
Gaudreault P, editors. Urgences et
soins intensifs pГ©diatriques. 2Г©me
édition, Paris: Presses de l’Université
de MontrГ©al et Doin; 2007.
Malhotra SP, Ivy DD, Mitchell MB,
Campbell DN, Dines M, Miyamoto S,
Duster M, Kay J, Lacour-Gayet F.
Performance of cavopulmonary palliation at elevated altitude: midterm
outcomes and risk factors for failure.
American Heart Association 2007
Scientific Sessions, November 3-7;
Orlando, FL: 2007.
Hunter KS. Modern medicine takes
simulation to heart: a fluid structure
interaction simulation is performed
to capture patient-specific modeling of hypertensive hemodynamics.
ANSYS Advantage. 2007; 1(1):12-3.
Mestroni L, Miyamoto SD, Taylor MR.
Genetics of dilated cardiomyopathy
conduction disease. Prog Pediatr
Cardiol. 2007;24:3-13.
Inge T, Wilson KA, Gamm K, Kirk S,
Garcia VF, Daniels SR. Preferential
loss of central adiposity in adolescent and young adults after laparoscopic gastric bypass. Surg Obes
Relat Dis. 2007;3(2):153-8. [PMID:
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Miyamoto SD, Gilbert D, Ballard A,
Anderson S, Le PN, Mitchell MM,
Campbell DN, Pietra BA. Campath1H therapy for resistant rejection in
pediatric heart transplant patients.
International Society of Heart and
Lung Transplantation 27th Annual
Meeting and Scientific Sessions,
April 27; San Francisco, CA; 2007.
Ivy DD, Doran AK, Claussen LC.
Transition of stable pediatric
patients with pulmonary arterial
hypertension from intravenous
epoprostenol to intravenous
treprostinil. Am J Cardiol. 2007;
99(5):696-8. [PMID: 17317374]
Miyamoto SD, Pietra BA. Heart
transplantation: post-transplant
management. In: Fine R, Harmon W,
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Blackwell Publishing; 2007.
Kavey RE, Allada V, Daniels SR,
Hayman LL, McCrindle BW,
Newburger JW, Parekh RS,
Steinberger J. Cardiovascular risk
reduction in high-risk pediatric
patients: a scientific statement from
the American Heart Association
Expert Panel on Population and
Prevention Science; the Councils
on Cardiovascular Disease in
the Young, Epidemiology and
Prevention, Nutrition, Physical
Activity and Metabolism, High
Blood Pressure Research,
Cardiovascular Nursing, and the
Kidney in Heart Disease; and the
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2007;22(3):218-53. [PMID: 17545824]
Munoz R, da Cruz E, Palacio G,
Marato C. In: Maroto C, editor.
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2007.
Kaza AK, Maldonado A, Miyamoto S,
Pietra B, Mitchell MB, Clark DR,
Campbell DN, Lacour-Gayet F.
Aristotle score predicts mortality
and morbidity in pediatric heart
transplantation. The Society of
Thoracic Surgeons 43rd Annual
Meeting, January 29-31; San Diego,
CA; 2007.
Myers PO, Cikirikcioglu M,
da Cruz E, Beghetti M, Kalangos A.
Extended resection and end-to-end
surgical repair for aortic coarctation and hypoplastic aortic arch
in infants. Proceedings of the 5th
Gemeinsamer Jahreskongress der
Schweizerischen Gesellschart fГјr
Chirurgie und der Schweizerischen
Gesellschaft für Thorax-, Herzund Gefässchirurgie. Swiss Knife.
2007;66:34-5.
Petitti DB, Imperatore G, Palla SL,
Daniels SR, Dolan LM, Kershnar AK,
Marcovina S, Pettitt DJ, Pihoker C,
Serum lipids and glucose control:
for the SEARCH for Diabetes in
Youth Study Group. Arch Pediatr
Adoles Med. 2007;161:159-65.
[PMID: 17283301]
Phelps CM, Tissot-Daguette C,
Buckvold S, Ivy DD, Pietra BA,
Miyamoto SD. Inotropic and
mechanical support in acute graft
rejection for pediatric heart transplant patients. Pediatr Crit Care
Med. 2007;8(3):A282.
2006-2008 Departmental Report
163
publications
Shaddy RE, Boucek MM, Hsu DT,
Boucek RJ, Canter CE, Mahony L,
Ross RD, Pahl E, Blume ED, Dodd DA,
Rosenthal DN, Burr J, LaSalle B,
Holubkov R, Lukas MA, Tani LY;
Pediatric Carvedilol Study Group.
Carvedilol for children and adolescents with heart failure: a randomized controlled trial. JAMA.
2007 Sep; 298(10):1171-9. [PMID:
17848651]
Sondheimer HM, Yetman AT,
Miyamoto SD. Cardiovascular
diseases. In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric diagnosis
and treatment. 18th ed. New York:
McGraw Hill; 2007.
Sun SS, Grave GD, Siervogel RM,
Pickoff AA, Arslanian SS, Daniels SR.
Systolic blood pressure in childhood
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2007;119:237-46. [PMID: 17272612]
Taylor MR, Ku L, Slavov D,
Cavanaugh J, Boucek M, Zhu X,
Graw S, Carniel E, Barnes C, Quan D,
Prall R, Lovell MA, Mierau G,
Ruegg P, Mandava N, Bristow MR,
Towbin JA, Mestroni L; Familial
Cardiomyopathy Registry. Danon
disease presenting with dilated
cardiomyopathy and a complex
phenotype. J Hum Genet. 2007;
52(10):830-5. [PMID: 17899313]
Taylor MR, Slavov D, Ku L,
Di Lenarda A, Sinagra G, Carniel E,
Haubold K, Boucek MM, Ferguson D,
Graw SL, Zhu X, Cavanaugh J,
Sucharov CC, Long CS, Bristow MR,
Lavori P, Mestroni L. Familial
Cardiomyopathy Registry; BEST
(Beta-Blocker Evaluation of Survival
Trial) DNA Bank. Prevalence of
desmin mutations in dilated
cardiomyopathy. Circulation.
2007 Mar;115(10):1244-51.
[PMID: 17325244]
Thompson DR, Obarzanek E,
Franko DL, Barton BA,
Morrison J, Biro FM, Daniels SR,
Streiegel-Moore RH. Childhood
overweight and cardiovascular
disease risk factors: The National
Heart, Lung and Blood Institute
Growth and Health Study. J Pediatr.
2007;150(1):18-25. [PMID: 17188606]
Tissot C, Aggoun Y, Beghetti M,
Sierra J, Kalangos A, da Cruz E. The
Lecompte maneuver as an alternative to reduction pulmonary arterioplasty for relief of airway compression in absent pulmonary valve
syndrome. Ann Thorac Surg. 2007
Feb;83:727. [PMID: 17258038]
Tissot C, Aggoun Y, Rimensberger PC,
Sierra J, Kalangos A, Beghetti M,
da Cruz E. Left ventricular epicardial
VVI pacing for a congenital complete heart block with severe myocardial dysfunction: shall epicardial
pacing wires be positioned left? Int
J Cardiol. 2007;116:e7-e9. [PMID:
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Van Hare GF, Colan SD, Javitz H,
Carmelli D, Knilans T, Schaffer M,
Kugler J, Byrum CJ, Saul JP and
Participating Members of the
Pediatric Electrophysiology Society.
Prospective assessment after pediatric ablation: fate of intracardiac
structure and function, as assessed
by serial echocardiography. Am
Heart J. 2007;153:815-20.e6. [PMID:
17452159]
Yetman AT, Beroukhim RS, Ivy DD,
Manchester D. Importance of the
clinical recognition of Loeys-Dietz
Syndrome in the neonatal period.
Pediatrics. 2007;119(5):1199-02.
[PMID: 17470566]
Tissot C, da Cruz E, Aggoun Y.
Rescue left main coronary artery
stenting for acute myocardial ischemia after coronary angiography
in a seven-years old girl with
homozygous familial hypercholesterolemia. Catheter Cardiovasc
Interv. 2007;69:243-47. [PMID:
17191220]
Zhang Y, Dunn ML, Hunter KS,
Lanning C, Ivy DD, Claussen L,
Chen J, Shandas R. Application
of a microstructural constitutive
model of the pulmonary artery to
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and effect of orthotropy. J Biomech
Eng. 2007;129(2):193-201. [PMID:
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Tissot C, da Cruz E, Aggoun Y.
Successful use of a new AmplatzerВ®
Vascular plug for percutaneous closure of a large aortopulmonary collateral artery in a pulmonary atresia
with ventricular septal defect prior
to complete repair. Int J Cardiol.
2007;116:e39-e41. [PMID: 17052781]
2006 Publications
American Heart Association Nutrition
Committee; Lichtenstein AH,
Appel LJ, Brands M, Carnethon M,
Daniels S, Franch HA, Franklin B,
Kris-Etherton P, Harris WS, Howard B,
Karanja N, Lefevre M, Rudel L,
Sacks F, Van Horn L, Winston M,
Wylie-Rosett J. Diet and lifestyle
recommendations revision 2006:
a scientific statement from the
American Heart Association
Nutrition Committee. Circulation.
2006 Jul;114(1):82-96. [PMID:
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Tissot C, Pache JC, da Cruz E.
A giant congenital left ventricular
diverticulum simulating an aneurysm. Eur Heart J. 2007;28:25.
[PMID: 16772341]
Tissot C, Rimensberger PC,
Aggoun Y, Kalangos A, Ozsahin H,
Beghetti M, da Cruz E. Tissue plasminogen activator for left atrial thrombus after Senning repair. Pediatr Crit
Care Med. 2007;8:279-81. [PMID:
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Appel LJ, Brands MW, Daniels SR,
Karanja N, Elmer PJ, Sacks FM;
American Heart Association. Dietary
approaches to prevent and treat
hypertension; a scientific statement from the American Heart
Association. Hypertension. 2006
Feb;47(2):296-308. [PMID: 16434724]
Artrip JH, Campbell DN, Ivy DD,
Almodovar MC, Chan KC,
Mitchell MB, Clarke DR,
Lacour-Gayet F. Birth weight and
complexity are significant factors
for the management of hypoplastic
left heart syndrome. Ann Thorac
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Discussion 1258-9. [PMID:
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Artrip JH, Sauer H, Campbell DN,
Mitchell MB, Haun C, Almodovar MC,
Hraska V, Lacour-Gayet F.
Biventricular repair in double
outlet right ventricle: surgical
results based on the STS-EACTS
International Nomenclature classification. Eur J Cardiothorac Surg.
2006 Apr;29(4):545-50. [PMID:
16495067]
Atherosclerosis, Hypertension, and
Obesity in the Young Committee
of the American Heart Association
Council on Cardiovascular Disease
in the Young; Alpert B, McCrindle B,
Daniels S, Dennison B, Hayman L,
Jacobson M, Mahoney L, Rocchini A,
Steinberger J, Urbina E, Williams R.
Recommendations for blood pressure measurement in human and
experimental animals; part 1: blood
pressure measurement in humans.
Hypertension. 2006 July;48(1):e3;
author reply e5. [PMID: 16769991]
Tissot-Daguette C, Buckvold S,
Phelps CM, Ivy DD, Campbell DN,
Mitchell MB, Pietra BA, Miyamoto SD.
Use of ECMO to reverse primary
graft failure after heart transplantation in children. Pediatr Crit Care
Med. 2007;8(3):A279.
Urbina EM, Bean JA, Daniels SR,
D’Alessio D, Dolan LM. Overweight
and hyperinsulinemia provide
individual contributions to compromises in brachial artery istensibility in healthy adolescents and
young adults. J Am Soc Hypertens.
2007;1(3):200-7. [PMID: 18431458]
1 64 D e p a r t m e n t o f P e d i a t r i c s
Kids in a red wagon, The Children’s Hospital
publications
Balistreri WF, Welch TR, Daniels SR.
Care of children with solid organ
transplants. In: McMillan JA,
Feigin RD, DeAngelis CD, Jones MD,
editors. Oski’s pediatrics. 4th ed.
Philadelphia: Lippincott William
Wilkens; 2006.
Bartz PJ, Driscoll DJ, Keane JF,
Gersony WM, Hayes CJ, Brenner JI,
O’Fallon WM, Pieroni DR, Wolfe RR,
Weidman WH. Management
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Berkowitz RI, Fujioka K, Daniels SR,
Hoppin AG, Owen S, Perry AC,
Sothern MS, Renz CL, Pirner MA,
Walch JK, Jasinsky O, Hewkin AC,
Blakesley VA. Sibutramine
Adolescent Study Group. Effects
of sibutramine treatment in obese
adolescents: a randomized trial.
Ann Intern Med. 2006 Jul;145(2):
81-90. Summary for patients in:
Ann Intern Med. 2006 Jul;145(2):
I16. [PMID: 16847290]
Beroukhim RS, Kruzick TL, Taylor AL,
Gao D, Yetman AT. Progression of
aortic dilation in children with a
functionally normal bicuspid aortic valve. Am J Cardiol. 2006 Sep;
98(6):828-30. [PMID: 16950196]
Beroukhim RS, Reed JH, Schaffer MS,
Yetman AT. Surgical correction of
mitral valve prolapse: a cure for
recurrent ventricular tachycardia in
Marfan syndrome? Pediatr Cardiol.
2006 Nov-Dec;27(6):755-8. [PMID:
17019535]
Beroukhim RS, Roosevelt G,
Yetman AT. Comparison of the
pattern of aortic dilation in children
with the Marfan’s syndrome versus
children with a bicuspid aortic
valve. Am J Cardiol. 2006 Oct;98(8):
1094-5. [PMID: 17027578]
Biro FM, Huang B, Crawford PB,
Lucky AW, Striegel-Moore R,
Barton BA, Daniels S. Pubertal
correlates in black and white girls.
J Pediatr. 2006 Feb;148(2):234-40.
[PMID: 16492435]
Blanchard BE, Tsongalis GJ,
Guidry MA, LaBelle LA, Poulin M,
Taylor AL, Maresh CM, Devaney J,
Thompson PD, Pescatello LS. RAAS
polymorphisms alter the acute
blood pressure response to aerobic
exercise among men with hypertension. Eur J Appl Physiol. 2006
May;97(1):26-33. [PMID: 16468060]
Burdette HL, Whitaker RC, Hall WC,
Daniels SR. Breastfeeding, introduction of complementary foods, and
adiposity at 5 years of age. Am J Clin
Nutr. 2006 Mar;83(3): 550-8. [PMID:
16522900]
Burdette HL, Whitaker RC, Hall WC,
Daniels SR. Maternal infant-feeding
style and children’s adiposity at
5 years of age. Arch Pediatr Adolesc
Med. 2006 May;160(5):513-20.
[PMID: 16651495]
Chhatriwalla AK, Younoszai A,
Latson L, Jaber WA. An 8-month-old
girl with an anomalous left coronary
artery from the pulmonary artery
complicated by myocardial ischemia
after surgical reimplantation. J Nucl
Cardiol. 2006 May-Jun;13(3):432-6.
[PMID: 16750788]
Daniels SR. Adolescent hypertension. In: McMillan JA, Feigin RD,
DeAngelis CD, Jones MD, editors.
Oski’s pediatrics. 4th ed. Philadelphia:
Lippincott William and Wilkens;
2006.
Daniels SR. The consequences
of childhood overweight and
obesity. Future Child. 2006
Spring;16(1):47-67. Review.
[PMID: 16532658]
Das BB, Taylor AL, Boucek MM,
Wolfe RR, Yetman AT. Exercise
capacity in pediatric heart transplant candidates: is there any
role for the 14 ml/kg/min guideline? Pediatr Cardiol. 2006 MarApr;27(2):226-9. [PMID: 16391994]
Das BB, Taylor AL, Yetman AT. Left
ventricular diastolic dysfunction
in children and young adults with
Marfan syndrome. Pediatr Cardiol.
2006 Mar-Apr;27(2):256-8. [PMID:
16463128]
Dyer K, Lanning C, Das B, Lee PF,
Ivy DD, Valdes-Cruz L, Shandas R.
Noninvasive Doppler tissue measurement of pulmonary artery
compliance in children with pulmonary hypertension. J Am Soc
Echocardiogr. 2006 Apr;19(4):
403-12. [PMID: 16581479]
Dyer KL, Pauliks LB, Das B,
Shandas R, Ivy D, Shaffer EM,
Valdes-Cruz LM. Use of myocardial
performance index in pediatric
patients with idiopathic pulmonary
arterial hypertension. J Am Soc
Echocardiogr. 2006 Jan;19(1):21-7.
[PMID: 16423665]
Flynn JT, Daniels SR. Pharmacologic
treatment of hypertension in children and adolescents. J Pediatr.
2006 Dec;149(6):746-54. [PMID:
17137886]
Friedman LA, Morrison JA,
Daniels SR, McCarthy WF,
Sprecher DL. Sensitivity and specificity of pediatric lipid determinations for adult lipid status: findings
from the Princeton Lipid Research
Clinics Prevalence Program
Follow-up Study. Pediatrics. 2006
Jul;118(1):165-72. [PMID: 16818562]
Gidding SS, Dennison BA,
Birch LL, Daniels SR, Gillman MW,
Lichtenstein AH, Rattay KT,
Steinberger J, Stettler N, Van Horn L;
American Heart Association.
Dietary recommendations for
children and adolescents; a guide
for practitioners. Pediatrics. 2006
Feb;117(2):544-59. [PMID: 16452380]
Griffiths LG, Bright JM. Chan KC.
Transcatheter intravascular stent
placement to relieve supravalvular
pulmonic stenosis. J Vet Cardiol.
2006;8:145-55. [PMID: 19083348]
Grundy SM, Cleeman JI, Daniels SR,
Donato KA, Eckel RH, Franklin BA,
Gordon DJ, Krauss RM, Savage PJ,
Smith SC Jr, Spertus JA, Costa F.
Diagnosis and management of the
metabolic syndrome: an American
Heart Association/National Heart,
Lung, and Blood Institute scientific
statement. Curr Opin Cardiol. 2006
Jan;21(1):1-6. [PMID: 16355022]
Guidry MA, Blanchard BE,
Thompson PD, Maresh CM, Seip RL,
Taylor AL, Pescatello LS. The influence of short and long duration on
the blood pressure response to an
acute bout of dynamic exercise. Am
Heart J. 2006 Jun;151(6):1322.e5-12.
[PMID: 16781245]
Hunter KS, Lanning CJ, Chen SY,
Zhang Y, Garg R, Ivy DD, Shandas R.
Simulations of congenital septal
defect closure and reactivity testing
in patient-specific models of the
pediatric pulmonary vasculature:
A 3D numerical study with fluidstructure interaction. J Biomech
Eng. 2006 Aug;128(4):564-72.
[PMID: 16813447]
Hunter KS, Zhang Y, Lanning C,
Ivy DD, Shandas R. Clinical and
numerical studies supporting pulmonary vascular input impedance
as a determinant of global vascular
stiffness in pediatric pulmonary
hypertension. Proceedings of
BIO2006; 2006 Jun 21-25; Amelia
Island, FL. Summer Bioengineering
Conference; 2006.
Inge T, Zeller M, Kirk S, Daniels S.
Surgical management of pediatric
obesity. Handbook of pediatric
obesity: clinical management.
2006;18:223-31.
Kavey RE, Allada V, Daniels SR,
Hayman LL, McCrindle BW,
Newburger JW, Parekh RS,
Steinberger J; American Heart
Association Expert Panel on
Population and Prevention Science;
American Heart Association Council
on Cardiovascular Disease in the
Young; American Heart Association
Council on Epidemiology and
Prevention; American Heart
Association Council on Nutrition,
Physical Activity and Metabolism;
American Heart Association Council
on High Blood Pressure Research;
American Heart Association
Council on Cardiovascular Nursing;
American Heart Association Council
on the Kidney in Heart Disease;
Interdisciplinary Working Group
on Quality of Care and Outcomes
Research. Cardiovascular risk
reduction in high-risk pediatric
patients: a scientific statement from
the American Heart Association
Expert Panel on Population and
Prevention Science; the Councils
on Cardiovascular Disease in
the Young, Epidemiology and
Prevention, Nutrition, Physical
Activity and Metabolism, High Blood
Pressure Research, Cardiovascular
Nursing, and the Kidney in Heart
Disease; and the Interdisciplinary
Working Group on Quality of
Care and Outcomes Research:
endorsed by the American Academy
of Pediatrics. Circulation. 2006
Dec;114(24):2710-38. Review. [PMID:
17130340]
2006-2008 Departmental Report
165
publications
Kershnar AK, Daniels SR, Imperatore G,
Palla SL, Petitti DB, Pettitt DJ,
Marcovina S, Dolan LM, Hamman RF,
Liese AD, Pihoker C, Rodriguez BL.
Lipid abnormalities are prevalent
in youth with type 1 and type 2
diabetes: the SEARCH for Diabetes
in Youth Study. J Pediatric. 2006
Sep;149(3):314-9. [PMID: 16939739]
Kimm SY, Glynn NW, McMahon RP,
Voorhees CC, Striegel-Moore RH,
Daniels SR. Self-perceived barriers
to activity participation among
sedentary adolescent girls. Med Sci
Sports Exerc. 2006 Mar;38(3):534-40.
[PMID: 16540842]
Kimm SY, Glynn NW, Obarzanek E,
Aston CE, Daniels SR. Racial
differences in correlates of misreporting of energy intake in
adolescent females. Obesity. 2006
Jan;14(1):156-64. [PMID: 16493134]
Ko HJ, Tan W, Stack R, Boppart SA.
Optical coherence elastography of
engineered and developing tissue.
Tissue Eng. 2006 Jan;12(1):63-73.
[PMID: 16499443]
Lauer RM, Burns TH, Daniels SR,
editors. Pediatric prevention of
atherosclerotic cardiovascular disease. New York: Oxford University
Press; 2006.
Lawson ML, Kirk S, Mitchell T,
Chen MK, Loux TJ, Daniels SR,
Harmon CM, Clements RH,
Garcia VF, Inge TH; Pediatric Bariatric
Study Group. One-year outcomes
of Roux-en-Y gastric bypass for
morbidly obese adolescents: a
multicenter study from the Pediatric
Bariatric Study Group. J Pediatr
Surg. 2006 Jan;41(1):137-43.
[PMID: 16410123]
Lichtenstein AH, Appel LJ, Brands M,
Carnethon M, Daniels S, Franch HA,
Franklin B, Kris-Etherton P, Harris WS,
Howard B, Karanja N, Lefevre M,
Rudel L, Sacks F, Van Horn L,
Winston M, Wylie-Rosett J. Summary
of American Heart Association Diet
and Lifestyle Recommendations
revision 2006. Aterioscler Thromb
Vasc Biol. 2006 Oct; 26(10):2186-91.
Review. [PMID: 16990564]
Lilje C, Weiss F, Lacour-Gayet F,
Ntalakoura K, Razek V, Weil J.
Images in cardiovascular medicine. Complete ectopia cordis.
Circulation. 2006 May;113(19):
e757-8. [PMID: 16702476]
Marcus BH, Williams DM, Dubbert PM,
Sallis JF, King AC, Yancey AK,
Franklin BA, Buchner D, Daniels SR,
Claytor RP; American Heart
Association Council on Nutrition,
Physical Activity, and Metabolism
(Subcommittee on Physical Activity);
American Heart Association Council
on Cardiovascular Disease in the
Young; Interdisciplinary Working
Group on Quality of Care and
Outcomes Research. Physical activity intervention studies: what we
know and what we need to know:
a scientific statement from the
American Heart Association Council
on Nutrition, on Cardiovascular
Disease in the Young; and the
Interdisciplinary Working Group
on Quality of Care and Outcomes
Research. Circulation. 2006 Dec;
114(24):2739-52. Review. [PMID:
17145995]
Mitsnefes MM, Kimball TR, Kartal J,
Witt SA, Glascock BJ, Khoury PR,
Daniels SR. Progression of left ventricular hypertrophy in children with
early chronic kidney disease: 2-year
follow-up study. J Pediatric. 2006
Nov;149(5):671-5. [PMID: 17095341]
Montgomery GS, Sagel SD, Taylor AL,
Abman SH. Effects of sildenafil
on pulmonary hypertension and
exercise tolerance in severe cystic
fibrosis-related lung disease. Pediatr
Pulmonol. 2006 Apr;41(4):383-5.
[PMID: 16479610]
Motti A, Tissot C, Rimensberger PC,
Prina-Rousso A, Aggoun Y,
Berner M, Beghetti M, da Cruz E.
Intravenous adenosine for refractory pulmonary hypertension in a
low-weight premature newborn:
a potential new drug for rescue
therapy. Pediatr Crit Care Med. 2006
July;7(4):380-2. [PMID: 16738499]
Notomi Y, Srinath G, Shiota T,
Martin-Miklovic MG, Beachler L,
Howell K, Oryszak SJ,
Deserranno DG, Freed AD,
Greenberg NL, Younoszai A,
Thomas JD. Maturational and
adaptive modulation of left ventricular torsional biomechanics:
Doppler tissue imaging observation from infancy to adulthood.
Circulation. 2006 May;113(21):
2534-41. PMID: 16717154.
1 66 D e p a r t m e n t o f P e d i a t r i c s
Orlando W, Shandas R, DeGroff C.
Efficiency differences in computational simulations of the total
cavo-pulmonary circulation with
and without compliant vessel
walls. Comput Methods Programs
Biomed. 2006 Mar;81(3):220-7.
[PMID: 16455152]
Parekh R, Mitsnefes M, Daniels S.
Cardiovascular disease in patients
with kidney disorders in childhood
and adolescence. In: Hogg R, editor.
Kidney disorders in children and
adolescents: a global perspective
of clinical practice. Boca Raton:
Taylor & Francis; 2006.
Paridon SM, Alpert BS, Boas SR,
Cabrera ME, Caldarera LL,
Daniels SR, Kimball TR, Knilans TK,
Nixon PA, Rhodes J, Yetman AT;
American Heart Association
Council on Cardiovascular Disease
in the Young, Committee on
Atherosclerosis, Hypertension,
and Obesity in Youth. Clinical
stress testing in the pediatric
age group: a statement from
the American Heart Association
Council on Cardiovascular Disease
in the Young, Committee on
Atherosclerosis, Hypertension,
and Obesity in Youth. Circulation.
2006 Apr;113(15):1905-20. [PMID:
16567564]
Rashid A, Ivy DD. Pulmonary hypertension in children. Curr Paediatr.
2006;16: 237-47.
Resnik E, Herron J, Fu R, Ivy DD,
Cornfield DN. Oxygen tension
modulates the expression of pulmonary vascular BKCa channel
alpha- and beta- subunits. Am
J Physiol Lung Cell Mol Physiol.
2006 Apr;290(4):L761-L8. [PMID:
16284215]
Rodriguez BL, Fujimoto WY,
Mayer-Davis EJ, Imperatore G,
Williams DE, Bell RA, Wadwa RP,
Palla SL, Liu LL, Kershnar A,
Daniels SR, Linder B. Prevalence of
cardiovascular disease risk factors in
U.S. children and adolescents with
diabetes: the SEARCH for diabetes
in youth study. Diabetes Care. 2006
Aug;29(8):1891-6. [PMID: 16873798]
Ross JS, Gross CP, Desai MM,
Hong Y, Grant AO, Daniels SR,
Hachinski VC, Gibbons RJ, Gardner TJ,
Krumholz HM. Effect of blinded
peer review on abstract acceptance.
JAMA. 2006 Apr;295(14):1675-80.
[PMID: 16609089]
Saelens BE, Couch SC, Wosje KS,
Stark LJ, Daniels SR. Relations
among milk and non-milk beverage
consumption, calcium, and relative weight in high-weight status
children. J Clin Psychol Med Setting.
2006;13(2):121-9.
Slifka AJ, Drexler ES, Wright JE,
Shandas R. Bubble-test method
for synthetic and bovine vascular
material. J Biomech. 2006;39(10):
1939-42. [PMID: 16085073]
Sondheimer HM, Rahimi-Alangi KL.
Current management of ventricular septal defect. Cardiol Young.
2006;16(3):131-5. [PMID: 17378052]
Striegel-Moore RH, Franko DL,
Thompson D, Barton B, Schreiber GB,
Daniels SR. Caffeine intake in eating
disorders. Int J Eat Diord. 2006 Mar;
39(2):162-5. [PMID: 16231346]
Striegel-Moore RH, Thompson D,
Affenito SG, Franko DL, Obarzanek E,
Barton BA, Schreiber GB,
Daniels SR, Schmidt M, Crawford PB.
Correlates of beverage intake in
adolescent girls: the National Heart,
Lung, and Blood Institute Growth
and Health Study. J Pediatr. 2006
Feb;148(2):183-7. [PMID: 16492426]
Striegel-Moore RH, Thompson DR,
Affenito SG, Franko DL, Barton BA,
Schreiber GB, Daniels SR, Schmidt M,
Crawford PB. Fruit and vegetable
intake: few adolescent girls meet
national guidelines. Prev Med. 2006
Mar;42(3):223-8. [PMID: 16406116]
Syme AN, Blanchard BE, Guidry MA,
Taylor AW, Vanheest JL, Hasson S,
Thompson PD, Pescatello LS. Peak
systolic blood pressure on a graded
maximal exercise test and the
blood pressure response to an
acute bout of submaximal exercise.
Am J Cardiol. 2006 Oct; 98(7):938-43.
[PMID: 16996879]
Tan W, Oldenburg A, Norman J,
Desai T, Boppart SA. Optical coherence tomography of cell dynamics
in three-dimensional tissue models.
Optic Express. 2006;14(16):7159-71.
Vinegoni C, Ralston T, Tan W, Luo W,
Marks DL, Boppart SA. Integrated
structural and functional optical
imaging combining spectral-domain
optical coherence and multiphoton microscopy. Appl Phys Lett.
2006;88:(5):053901.
publications
Wang R, Lacour-Gayet FG,
Lanning CJ, Rech BA, Kilfoil PJ,
Hertzberg J, Shandas R. Initial
experience with the development
and numerical and in vitro studies
of a novel low-pressure artificial
right ventricle for pediatric Fontan
patients. ASAIO J. 2006 Nov-Dec;
52(6):682-92. [PMID: 17117059]
Woo JG, Dolan LM, Deka R,
Kaushal RD, Shen Y, Pal P, Daniels SR,
Martin LJ. Interactions between
noncontiguous haplotypes in the
adiponectin gene ACDC are associated with plasma adiponectin.
Diabetes. 2006 Feb;55(2):523-9.
[PMID: 16443790]
Xanthakos S, Miles L, Bucuvalas J,
Daniels S, Garcia V, Inge T. Histologic
spectrum of nonalcoholic fatty liver
disease in morbidly obese adolescents. Clin Gastroenterol Hepatol.
2006 Feb;4(2):226-32. [PMID:
16469684]
Xanthakos SA, Daniels SR, Inge TH.
Bariatric surgery in adolescents:
an update. Adolesc Med Clin. 2006
Oct;17(3):589-612. [PMID: 17030281]
Xu C, Vinegoni C, Ralston TS, Luo W,
Tan W, Boppart SA. Spectroscopic
spectral-domain optical coherence microscopy. Opt Lett. 2006
Apr;31(8):1079-81. [PMID: 16625909]
Zeller MH, Roehrig HR, Modi AC,
Daniels SR, Inge TH. Health-related
quality of life and depressive
symptoms in adolescents with
extreme obesity presenting
for bariatric surgery. Pediatrics.
2006 Apr;117(4):1155-61. [PMID:
16585310]
Zheng H, Barker A, Shandas R.
Predicting backscatter characteristics from micron- and submicron
– scale ultrasound contrast agents
using a size-integration technique.
IEEE Trans Ultrason Ferroelectr Freq
Control. 2006 Mar;53(3):639-44.
[PMID: 16555773]
Zheng H, Mukdadi O, Shandas R.
Theoretical predictions of harmonic
generation from submicron ultrasound contrast agents for nonlinear
biomedical ultrasound imaging.
Phys Med Biol. 2006 Feb;51(3):55773. [PMID: 16424581]
Child Health Associate/
Physician Assistant Program
2008 Publications
Glicken AD. Evidence based medicine. In: Ballweg R, Sullivan E,
Brown D, Vetrosky D, editors.
Physician assistant: a guide to clinical practice. 4th ed. Philadelphia:
WB Saunders Company; 2008.
Glicken AD. Excellence in physician
assistant training through faculty
development. Acad Med. 2008
Nov;83(11):1107-10. [PMID:
18971668]
Glicken AD. Vision, leadership and
curricular change, musings of a
past president. PAEA Networker
[Internet]. 2008 Mar;3(3). Available
from: http://www.paeaonline.org/
archive/Networker/0308Networker/
0308Glicken.html
Kaye CI, Newborn Screening Clinical
Report Writing Group. Newborn
screening expands: recommendations for pediatricians and medical
homes, implications for the future.
Pediatrics. 2008;121(1):192-217.
Robohm C. Pediatric emergency
medicine for the physician assistant
student. Infectious diseases unit:
Pediatric urinary tract infections?
A case study [Internet]. Medical
University of South Carolina College
of Health Professionals; 2008.
Available from: http://www.musc.
edu/chp/papem.
2007 Publications
Glicken AD. Becoming a knowledgebased association. PAEA Networker
[Internet]. 2007 Jan;2(1). Available
from: http://www.paeaonline.org/
archive/Networker/0107Networker/
0107Glicken.htm
Glicken AD. Introducing critical
evaluation. In: Shank P, editor. The
online learning idea book. Hoboken:
John Wiley & Sons; 2007.
Glicken AD. Partnerships: an important piece of our past and our
future. PAEA Networker [Internet].
2007 Jun;2(6). Available from: http://
www.paeaonline.org/archive/
Networker/0607Networker/
0607Glicken.htm
Glicken AD. Putting a face on genetics – a matter of perspective. PAEA
Networker [Internet]. 2007 Oct;2(10).
Available from: http://www.paea
online.org/archive/Networker/
1007Networker/1007Glicken.html
Glicken AD, Lane S. Results of the
PAEA 2006 survey of PA program
expansion plans. J Phys Assist Edu
Assoc. 2007;18(1):48-53.
Glicken AD, Merenstein G, Arthur M.
The child health associate physician assistant program, an enduring educational model addressing the needs of families and
children. J Phys Assist Edu Assoc.
2007;18(3):24-9.
Glicken AD, Merenstein GB.
Addressing the hidden curriculum:
understanding educator professionalism. Med Teach. 2007
Feb;29(1):54-7. [PMID: 17538835]
Kaye CI, Recommendations from the
EGAPP Working Group. Testing for
cytochrome P450 polymorphisms
in adults with nonpsychotic depression treated with selective serotonin
reuptake inhibitors. Genet Med.
2007;9(12):819.
Kaye CI, Livingston JL, Canfield MA,
Mann MY, Lloyd-Puryear MA,
Therrell BL. Assuring clinical genetic
services for newborns identified
through U.S. newborn screening programs. Geneti Med. 2007
Aug;9:518-27. [PMID: 17700390]
Miller A, Glicken AD. The future of
physician assistant education. J Phys
Assist Edu Assoc. 2007;18(3):109-16.
2006 Publications
Glicken AD. An educator in the
PA profession: a good place to be.
PAEA Networker [Internet]. 2006
May;1(2). Available from: http://
www.paeaonline.org/archive/
Networker/0506Networker/
0506Glicken.html
Glicken AD. Looking toward the
future. APAP Update [Internet].
2006 Jan. Available from: http://
www.paeaonline.org/
Glicken AD. Qualitative methods
in research. In: Blessing D, editor. Physician assistant’s guide to
research and medical literature.
2nd ed. Philadelphia: FA Davis
Company; 2006.
Glicken AD, Merenstein G, Nieman J.
Student clinical tracking of psychiatric and behavioral diagnoses in
primary care. Physician Assistant
Education Association Annual
Education Forum; 2006 Oct 25-29;
Quebec City Canada. J Phys Assist
Edu. 2006;17(4):34.
Glicken AD, Tappero E,
Merenstein GB. Evidenced based
clinical practice decisions. In:
Merenstein GB, Gardner SL, editors.
Handbook of neonatal intensive
care. 6th ed. St Louis: CV Mosby;
2006.
Kaye CI, American Academy of
Pediatrics, Rose SR; Section on
Endocrinology and Committee
on Genetics, American Thyroid
Association, Brown RS; Public
Health Committee, Lawson Wilkins
Pediatric Endocrine Society; Foley T,
Kaplowitz PB, Kaye CI, Sundararajan S,
Varma SK. Update of newborn
screening and therapy for congenital hypothyroidism. Pediatrics. 2006
Jun;117(6):2290.
Kaye CI, Committee on Genetics,
Accurso F, La Franchi S, Lane PA,
Hope N, Sonya P, G Bradley S,
Michele A LP. Newborn screening fact sheets. Pediatrics. 2006
Sep;118(3):e934-63. [PMID:
16950973]
Kaye CI, Committee on Genetics,
Accurso F, La Franchi S, Lane PA,
Northrup H, Pang S, Schaefer GB.
Introduction to the newborn
screening fact sheets. Pediatrics.
2006 Sep;118(3):1304-12. [PMID:
16960984]
Robohm C. Trends in Religious and
spiritual indicators in physician
assistant student application essays.
Physician Assistant Education
Association Annual Education
Forum, 2006 Oct 25-29; Quebec
City, Canada. J Phys Assist Edu.
2006;17(4):34.
Robohm C, Bowser J. When do
applicants learn about the physician
assistant program? One program’s
nine-year experience. Physician
Assistant Education Association
Annual Education Forum, 2006
Oct 25-29; Quebec City, Canada.
J Phys Assist Edu. 2006;17(4):34.
Ruff C, Gray J, Arthur M,
Merenstein G, Development and
outcomes of a rural track within
a primary care physician assistant
program. J Phys Assist Edu Assoc.
2006;17(4):37-41.
Watson J, Robohm C. Academic
accommodations for religious
beliefs: avoiding religious discrimination. J Phys Assist Edu.
2006;17(4):22-5.
2006-2008 Departmental Report
167
publications
Child Neurology
2008 Publications
Bernard TJ, Goldenberg NA.
Pediatric arterial ischemic stroke.
Pediatr Clin North Am. 2008
Apr;55(2):323-38, viii. [PMID:
18381089]
Bernard TJ, Goldenberg NA,
Armstrong-Wells J, Amlie-Lefond C,
Fullerton HJ. Treatment of childhood arterial ischemic stroke.
Ann Neurol. 2008 Jun;63(6):679-96.
[PMID: 18496844]
Cornejo BJ, Mesches MH, Benke TA.
A single early-life seizure impairs
short-term memory but does not
alter spatial learning, recognition
memory, or anxiety. Epilepsy Behav.
2008 Nov;13(4):585-92. [PMID:
18678283]
Dobyns WB, Mirzaa G, Christian SL,
Petras K, Roseberry J, Clark GD,
Curry CJR, McDonald-McGinn D,
Medne L, Zackai E, Parsons J,
Zand DJ, Hisama FM, Walsh CA,
Leventer RJ, Martin CL, Gajecka M,
Shaffer LG. Consistent chromosome
abnormalities identify novel polymicrogyria loci in 1p36.3, 2p16.1
p23.1, 4q21.21-q22.1, 6q26-q27
and 21q2. Am J Med Gen. Part A
2008 Jul;146A(13):1637-54. [PMID:
18536050]
Goldenberg NA, Bernard TJ.
Venous thromboembolism in
children. Pediatr Clin North Am.
2008 Apr;55(2):305-22, vii. [PMID:
18381088]
Goldenberg NA, Bernard TJ,
Gordon A, Fullerton H, deVeber GA.
Acute treatment and short-term
outcomes in childhood arterial
ischemic stroke; first analysis of
the International Pediatric Stroke
Study. 50th Annual Meeting of the
American Society of Hematology.
2008 Dec 6-9; San Francisco. San
Francisco, CA: American Society of
Hematology; 2008.
Hu Y, Lund IV, Gravielle M, Farb DH,
Brooks-Kayal AR, Russek SJ. Surface
expression of GABAA receptors
is transcriptionally controlled by
the interplay of cAMP-response
element-binding protein and its
binding partner inducible cAMP
early repressor. J Biol Chem.
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Kraus DM, Elliott GS, Chute H,
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Magera MJ, Gunawardena ND,
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PagГЎn-Mercado G, OrtГ­z I,
Rivera-Caragol E, Spritz RA,
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Spritz RA. The genetics of generalized vitiligo and associated
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Teng W, Shan Z, Teng X, Guan H,
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Tsai AC, Fine CA, Yang M, Walton CS,
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Wang D, Wei Y, Schmoll D,
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Wang XX, Pfenninger KH. Functional
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Das M, Burns N, Wilson SJ,
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Crossno JT Jr, Garat CV, Reusch JE,
Morris KG, Dempsey EC,
McMurtry IF, Stenmark KR,
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Czaja AS. A critical appraisal of a
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(calfactant) in pediatric acute lung
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Developmental expression of the
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Nozik-Grayck E, Stenmark KR. Role of
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Davie NJ, Gerasimovskaya EV,
Hofmeister SE, Richman AP,
Jones PL, Reeves JT, Stenmark KR.
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vasa vasorum neovascularization:
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Frid MG, Brunetti JA, Burke DL,
Carpenter TC, Davie NJ, Reeves JT,
Roedersheimer MT, van Rooijen N,
Stenmark KR. Hypoxia-induced
pulmonary vascular remodeling
requires recruitment of circulating mesenchymal precursors of a
monocyte/macrophage lineage.
Am J Pathol. 2006 Feb;168(2):
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Liu E, MacKenzie T, Dobyns EL,
Parikh CR, Karrer FM, Narkewicz MR,
Sokol RJ. Characterization of acute
liver failure and development of a
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Short MD, Fox SM, Lam CF,
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Stenmark KR, Davie N, Frid M,
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the adventitia in pulmonary vascular remodeling. Physiology. 2006
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Stenmark KR, Fagan KA, Frid MG.
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Wenzlau JM, Garl PJ, Simpson P,
Stenmark KR, West J, Artinger KB,
Nemenoff RA, Weiser-Evans MC.
Embryonic growth-associated
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essential for embryonic vascular
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Dermatology
2008 Publications
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2007 Publications
Arbuckle HA, Leibold AM. Disorders
of keratinization. In: Fitzpartick JE,
Morelli JG, editors. Dermatology
secrets in color. 3rd ed. Philadelphia:
Mosby; 2007.
Tauscher A, Burch JM. Picture of
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Beigel J, Kohl KS, Khuri-Bulos N,
Bravo L, Nell P, Marcy SM,
Warschaw K, Ong-Lim A,
Poerschke G, Weston W,
Lindstrom JA, Stoltman G,
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and presentation of immunization
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Arbuckle HA, Morelli J. HolocarВ­
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Burch JM, Aeling JL. Acne and
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secrets. 3rd ed. Philadelphia:
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Cothren CC, Moore EE, Ray CE Jr,
Johnson JL, Moore JB, Burch JM.
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blunt cerebrovascular injury.
Surgery. 2007 Jan;141(1):76-82.
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Cothren CC, Moore EE, Zent RM,
Burch JM. Blunt vertebral artery
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Dodd AT, Morelli J, Mokrohisky ST,
Asdigian N, Byers TE, Crane LA.
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Morelli JG. Part XXX. The skin.
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Morelli JG, Burch JM. Skin.
In: Hay WW Jr, Levin MJ,
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Prok LD, Arbuckle HA. Nevi in children: a practical approach to evaluation. Pediatr Ann. 2007 Jan;36(1):
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Burch JM, Fassihi H, Jones CA,
Mengshol SC, Fitzpatrick JE,
McGrath JA. Kindler syndrome: a
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Ciesla DJ, Moore EE, Cothren CC,
Johnson JL, Burch JM. Has the
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Ciesla DJ, Moore EE, Johnson JL,
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Sauaia A. Decreased progression of
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acute respiratory distress syndrome
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Cothren CC, Moore EE, Johnson JL,
Moore JB, Burch JM. One hundred
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Crane LA, Deas A, Mokrohisky ST,
Ehrsam G, Jones RH, Dellavalle R,
Byers TE, Morelli J. A randomized
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Dellavalle RP, Heilig LF, Francis SO,
Johnson KR, Hester EJ, McNealy KM,
Schilling LM, Weston WL. What
dermatologists do not know about
smallpox vaccination: results from
a worldwide electronic survey.
J Invest Dermatol. 2006 May;126(5):
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Sheppard FR, Cothren CC, Moore EE,
Orfanakis A, Ciesla DJ, Johnson JL,
Burch JM. Emergency department
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Weston WL, Morelli JG. Dermatitis
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Developmental and
Behavioral Pediatrics
2008 Publications
Ben-Shachar S, Ou Z, Shaw CA,
Belmont JW, Patel MS, Hummel M,
Amato S, Tartaglia N, Berg J,
Sutton VR, Lalani SR, Chinault AC,
Cheung SW, Lupski JR, Patel A.
22q11.2 distal deletion: a recurrent
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2008 Jan;82(1):214-21. [PMID:
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Brega AG, Goodrich G, Bennett RE,
Hessl D, Engle K, Leehey MA,
Bounds LS, Paulich MJ, Hagerman RJ,
Hagerman PJ, Cogswell JB,
Tassone F, Reynolds A, Kooken R,
Kenny M, Grigsby J. The primary
cognitive deficit among males with
fragile X-associated tremor/ataxia
syndrome (FXTAS) is a dysexecutive
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Goldson E, Bonner BL. Child
malВ­treatment: developmental
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Philadelphia: Mosby; 2008.
Goldson E, Gardner SL. The effects
of adverse neonatal factors and
prematurity. In: Wolraich ML,
Drotar DD, Dworkin PH, Perrin EC,
editors. Developmental-behavioral
pediatrics: evidence and practice.
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Goldson E, Reynolds A. Child
development and behavior.
In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
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diagnosis and treatment. 19th ed.
New York: McGraw Hill; 2009.
Greco CM, Tassone F,
Garcia-Arocena D, Tartaglia N,
Coffey SM, Vartanian TK,
Brunberg JA, Hagerman PJ,
Hagerman RJ. Clinical and neuropathologic findings in a woman
with the FMR1 premutation and
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2008 Aug;65(8):1114-6. [PMID:
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Coffey SM, Cook K, Tartaglia N,
Tassone F, Nguyen DV, Pan R,
Bronsky HE, Yuhas J,
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Doerflinger M, Hagerman PJ,
Hagerman RJ. Expanded clinical
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Grigsby J, Brega AG, Engle K,
Leehey MA, Hagerman RJ, Tassone F,
Hessl D, Hagerman PJ, Cogswell JB,
Bennett RE, Cook K, Hall DA,
Bounds LS, Paulich MJ, Reynolds A.
Cognitive profile of fragile X premutation carriers with and without
fragile X-associated tremor/ataxia
syndrome. Neuropsychology. 2008
Jan;22(1):48-60. [PMID: 18211155]
Gabriels RL, Agnew JA, Miller LJ,
Gralla J, Pan Z, Goldson E,
Ledbetter JC, Dinkens JP, Hooks E.
Is there a relationship between
restricted, repetitive, stereotyped
behaviors and interests and abnormal sensory response in children
with autism spectrum disorders?
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2:660-70.
Leehey MA, Berry-Kravis E, Goetz CG,
Zhang L, Hall DA, Li L, Rice CD, Lara R,
Cogswell J, Reynolds A, Gane L,
Jacquemont S, Tassone F, Grigsby J,
Hagerman RJ, Hagerman PJ.
FMR1 CGG repeat length predicts
motor dysfunction in premutation
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Garcia-Nonell C, Ratera ER, Harris S,
Hessl D, Ono MY, Tartaglia N,
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Murphy M. Developmental management of toddlers and preschoolers.
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publications
Tartaglia N, Davis S, Hench A,
Nimishakavi S, Beauregard R,
Reynolds A, Fenton L, Albrecht L,
Ross J, Visootsak J, Hansen R,
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2007 Publications
Berry-Kravis E, Goetz CG, Leehey MA,
Hagerman RJ, Zhang L, Li L,
Nguyen D, Hall DA, Tartaglia N,
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Bross DC, Goldson E. The reality
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and violence. Tokyo: Akashi; 2007.
Goldson E, Bauman M. Medical
health assessment and treatment
issues in autism. In: Gabriels RL,
Hill DE, editors. Growing up with
autism: working with school-age
children and adolescents. New York:
Guilford Press; 2007.
Goldson E, Reynolds A. Child
development and behavior.
In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric
diagnosis and treatment. 18th ed.
New York: McGraw Hill; 2007.
Leehey MA, Berry-Kravis E, Min SJ,
Hall DA, Rice CD, Zhang L, Grigsby J,
Greco CM, Reynolds A, Lara R,
Cogswell J, Jacquemont S,
Hessl DR, Tassone F, Hagerman R,
Hagerman PJ. Progression of
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Visootsak J, Rosner B, Dykens E,
Tartaglia N, Graham JM Jr.
Behavioral phenotype of sex
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Am J Med Genet A. 2007 Jun;
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2006 Publications
Federico SG, Zachar PA, Oravec CM,
Mandler T, Goldson E, Brown J.
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health elective: the University of
Colorado Department of Pediatrics’
experience. Arch Pediatr Adolesc
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Gardner S, Goldson E. The neonate
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Gardner S, editors. Handbook of
neonatal intensive care. 6th ed.
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Goldson E. Behavioral issues in the
care of children with special health
care needs. In: Greydanus DE,
Patel DR, Pratt HD, editors. Behavioral
pediatrics. 2nd ed. New York:
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Goldson E, Louch G, Washington K,
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Developmental Biology
2008 Publications
Desai S, Loomis Z, Pugh-Bernard A,
Schrunk J, Doyle MJ, Minic A,
McCoy E, Sussel L. Nkx2.2 regulates
cell fate choice in the enteroendocrine cell lineages of the intestine.
Dev Biol. 2008 Jan;313(1):58-66.
[PMID: 18022152]
Hoover AM, Wynkoop A, Zeng H,
Jia J, Niswander LA, Liu A. C2cd3 is
required for cilia formation and
Hedgehog signaling in the mouse.
Development. 2008 Dec;135(24):
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Kim H, Shin J, Kim S, Poling J,
Park HC, Appel B. Notch-regulated
oligodendrocyte specification
from radial glia in the spinal cord
of zebrafish embryos. Dev Dyn.
2008 Aug;237(8):2081-9. [PMID:
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Kim TH, Goodman J, Anderson KV,
Niswander L. Phactr4 regulates
neural tube and optic fissure closure
by controlling PP1-, Rb-, and E2F1regulated cell-cycle progression.
Dev Cell. 2007 Jul;13(1):87-102.
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Kucenas S, Takada N, Park HC,
Woodruff E, Broadie K, Appel B.
CNS-derived glia ensheath peripheral nerves and mediate motor root
development. Nat Neurosci. 2008
Feb;11(2):143-51. [PMID: 18176560]
Park HC, Shin J, Roberts RK, Appel
B. An olig2 reporter gene marks
oligodendroycte precursors in postВ­
embryonic spinal cord of zebrafish.
Dev Dyn. 2007 Dec;236(12):3402-7.
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McFarland KA, Topczewska JM,
Weidinger G, Dorsky RI, Appel B.
Hh and Wnt signaling regulate
formation of olig2+ neurons in the
zebrafish cerebellum. Dev Biol. 2008
Jun;318(1):162-71. [PMID: 18423594]
Sarmah B, Winfrey VP, Olson GE,
Appel B, Wente SR. A role for the
inositol kinase Ipk1 in ciliary beating
and length maintenance. Proc Natl
Acad Sci USA. 2007 Dec;104(50):
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Niswander L. Methods in avian
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Sears KE, Behringer RR,
Rasweiler JJ 4th, Niswander LA.
The evolutionary and developmental basis of parallel reduction in
mammalian zeugopod elements.
Am Nat. 2007 Jan;169(1):105-17.
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Qu X, Jia H, Garrity DM, Tompkins K,
Batts L, Appel B, Zhong TP,
Baldwin HS. ndrg4 is required for
normal myocyte proliferation during early cardiac development
in zebrafish. Dev Biol. 2008 May;
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2007 Publications
Barna M, Niswander L. Visualization
of cartilage formation: insight
into cellular properties of skeletal
progenitors and chondrodysplasia syndromes. Dev Cell. 2007
Jun;12(6):931-41. [PMID: 17543865]
Sears KE, Goswami A, Flynn JJ,
Niswander LA. The correlated
evolution of Runx2 tandem repeats,
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length in carnivora. Evol Dev.
2007 Nov-Dec;9(6):555-65. [PMID:
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Shin J, Poling J, Park HC, Appel B.
Notch signaling regulates neural
precursor allocation and binary neuronal fate decisions in zebrafish.
Development. 2007 May;134(10):
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Chao CS, Loomis ZL, Lee JE,
Sussel L Genetic identification of
a novel NeuroD1 function in the
early differentiation of islet alpha,
PP and epsilon cells. Dev Biol.
2007 Dec;312(2):523-32. [PMID:
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Weatherbee SA, Niswander L.
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and osteogenesis in limbs.
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evolution, development, and transformation. Chicago: The University
of Chicago Press; 2007.
Doyle MJ, Loomis ZL, Sussel L.
Nkx2.2-repressor activity is sufficient
to specify alpha-cells and a small
number of beta-cells in the pancreatic islet. Development. 2007
Feb;134(3):515-23. [PMID: 17202186]
Zohn IE, Anderson KV, Niswander L.
The Hectd1 ubiquitin ligase is
required for development of the
head mesenchyme and neural
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Doyle MJ, Sussel L. Nkx2.2 regulates
beta-cell function in the mature
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Zohn IE, De Domenico I, Pollock A,
Ward DM, Goodman JF, Liang X,
Sanchez AJ, Niswander L, Kaplan J.
The flatiron mutation in mouse
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publications
2006 Publications
Atit R, Sgaier SK, Mohamed OA,
Taketo MM, Dufort D, Joyner AL,
Niswander L, Conlon RA. Betacatenin activation is necessary
and sufficient to specify the dorsal
dermal fate in the mouse. Dev Biol.
2006 Aug;296(1):164-76. [PMID:
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Decker K, Goldman DC, Grasch CL,
Sussel L. Gata6 is an important
regulator of mouse pancreas
development. Dev Biol. 2006 Oct;
298(2):415-29. [PMID: 16887115]
Kirby B, Takada N, Latimer AJ,
Shin J, Appel B. In vivo imaging
shows dynamic oligodendrocyte
progenitor behavior during zebraВ­
fish development. Nat Neurosci.
2006 Dec;9(12):1506-11. [PMID:
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Latimer AJ, Appel B. Notch signaling
regulates midline cell specification
and proliferation in zebrafish. Dev
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Prakash N, Brodski C, Naserke T,
Puelles E, Gogoi R, Hall A,
Panhuysen M, Echevarria D, Sussel L,
Weisenhorn DM, Martinez S,
Arenas E, Simeone A, Wurst W.
Wnt1-regulated genetic network
controls the identity and fate of
midbrain-dopaminergic progenitors in vivo. Development. 2006
Jan;133(1):89-98. [PMID: 16339193]
Raum JC, Gerrish K, Artner I,
Henderson E, Guo M, Sussel L,
Schisler JC, Newgard CB, Stein R.
FoxA2, Nkx2.2, and PDX-1 regulate
islet beta-cell-specific mafA expression through conserved sequences
located between base pairs -8118
and -7750 upstream from the transcription start site. Mol Cell Biol.
2006 Aug;26(15):5735-43. [PMID:
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Sears KE, Behringer RR, Rasweiler JJ
4th, Niswander LA. Development
of bat flight: morphologic and
molecular evolution of bat wing
digits. Proc Natl Acad Sci USA.
2006 Apr;103(17):6581-6. [PMID:
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Weatherbee SD, Anderson KV,
Niswander LA. LDL-receptorrelated protein 4 is crucial for
formation of the neuromuscular
junction. Development. 2006
Dec;133(24):4993-5000. [PMID:
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Weatherbee SD, Behringer RR,
Rasweiler JJ 4th, Niswander LA.
Interdigital webbing retention
in bat wings illustrates genetic
changes underlying amniote limb
diversification. Proc Natl Acad Sci
USA. 2006 Oct;103(41):15103-7.
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Zohn IE, Li Y, Skolnik EY, Anderson
KV, Han J, Niswander L. p38 and a
p38-interacting protein are critical
for downregulation of E-cadherin
during mouse gastrulation. Cell.
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Emergency Medicine
2008 Publications
Atabaki SM, Stiell IG, Bazarian JJ,
Sadow KE, Vu TT, Camarca MA,
Berns S, Chamberlain J. A clinical
decision rule for cranial computed
tomography in minor pediatric head
trauma. Arch Pediatr Adolesc Med.
2008 May;162(5):439-45. [PMID:
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Bhende M, Tham E. Eye Irrigation.
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Loiselle J, Ruddy RM, editors.
Textbook of pediatric emergency
procedures. 2nd ed. Philadelphia:
Lippincott Williams Wilkins; 2008.
Brent A. Pediatric sepsis.
In: Shockley L, Duvall, editors.
Mosby’s handbook of emergency
care. Philadelphia: Elsevier; 2008.
Clarke W, Jones T, Rewers A,
Dunger D, Klingensmith GJ.
Assessment and management
of hypoglycemia in children and
adolescents with diabetes. Pediatr
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Emery KD, Faries SG. The lack of
motor vehicle occupant restraint
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Emery KD, Luna M. Otitis, sinusitis
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Mosby’s handbook of emergency
care. Philadelphia: Elsevier; 2008.
Glaser NS, Marcin JP,
Wootton-Gorges SL, Buonocore MH,
Rewers A, Strain J, Dicarlo J,
Neely EK, Barnes P, Kuppermann N.
Correlation of clinical and biochemical findings with diabetic
ketoacidosis-related cerebral edema
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Hematology, Oncology and
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Araya CE, Mehta MB,
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in high-risk childhood acute lymphoblastic leukemia: a Children’s
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Rotbart HA. Germ proof your twins.
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2007. Philadelphia: Elsevier/
Saunders; 2007.
Abzug MJ, Song LY, Fenton T,
Nachman SA, Levin MJ,
Rosenblatt HM, Pelton SI,
Borkowsky W, Edwards KM,
Peters J. Pertussis booster vaccination in HIV-infected children
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Brisson M, Pellissier JM, Levin MJ.
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2007 Dec;45(11):1527-9. [PMID:
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Daley MF, Nyquist A-C, Simoes EAF.
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Deterding RR, Wong S, Faries G,
Glover JJ, Garrington TP, Wang M,
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Dominguez SR, O’Shea TJ, Oko LM,
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Dworkin RH, Johnson RW, Breuer J,
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Betts RF, Gershon AA, Haanpaa ML,
McKendrick MW, Nurmikko TJ,
Oaklander AL, Oxman MN,
Pavan-Langston D, Petersen KL,
Rowbotham MC, Schmader KE,
Stacey BR, Tyring SK, van Wijck AJ,
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Enomoto LM, Kloberdanz KJ,
Mack DG, Elizabeth D, Weinberg A.
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publications
Faridi Z, Grunbaum JA, Gray BS,
Franks A, Simoes E. Communitybased participatory research: necessary next steps. Prev Chronic Dis.
2007 Jul;4(3):A70. [PMID: 17572974]
Gelston CD, Durairaj VD, Simoes EA.
Rhino-orbital mucormycosis causing
cavernous sinus and internal carotid
thrombosis treated with posaconВ­
azole. Arch Ophthalmol. 2007 Jun;
125(6):848-9. [PMID: 17563004]
Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric
diagnosis and treatment. 18th ed.
New York: McGraw Hill; 2007.
Kisich KO, Howell MD,
Boguniewicz M, Heizer HR,
Watson NU, Leung DY. The constiВ­
tuВ­tive capacity of human keratinocytes to kill Staphylococcus
aureus is dependent on betadefensin 3. J Invest Dermatol.
2007 Oct;127(10):2368-80. [PMID:
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Levin MJ. Varicella vaccination of
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Levin MJ, Weinberg A. Infections:
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Loparev VN, Rubtcova E, Seward JF,
Levin MJ, Schmid DS. DNA sequence
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death in underfives hospitalised
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Erma Abucejo-Ladesma P,
Quiambao BP, Gozum L,
Sombrero LT, Romano V,
Herva E, Riley I, Simoes EA.
Predictors of death from severe
pneumonia among children 2-59
months old hospitalized in Bohol,
Philippines: implications for referral criteria at a first-level health
facility. Trop Med Int Health. 2007
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McFarland EJ. Human immunoВ­
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McKinney RE, Rodman J, Hu C,
Britto P, Hughes M, Smith ME,
Serchuk LK, Kraimer J, Ortiz AA,
Flynn P, Yogev R, Spector S,
Draper L, Tran P, Scites M,
Dickover R, Weinberg A,
Cunningham C, Abrams E,
Blum MR, Chittick GE, Reynolds L,
Rathore M; Pediatric AIDS Clinical
Trials Group Protocol P1021 Study
Team. Long-term safety and efficacy
of a once-daily regimen of emtrictabine, didanosine, and efavirenz in
HIV-infected, therapy-naive children
and adolescents (Pediatric AIDS
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Nyquist AC. Influenza virus mutation
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Nyquist AC, Sigel EJ, Levin MJ.
Sexually transmitted infections.
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Sondheimer JM, Deterding RR,
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diagnosis and treatment. 18th ed.
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Ogle JW. Antimicrobial therapy
of pediatric infections.
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Sondheimer JM, Deterding RR,
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diagnosis and treatment. 18th ed.
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Ogle JW, Anderson MA. Infections:
bacterial and spirochetal.
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Sondheimer JM, Deterding RR,
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diagnosis and treatment. 18th ed.
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Parker SK, Curtin KM, Vasil ML.
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an activity associated with mycobacterial cutinase. J Bacteriol.
2007 Jun;189(11):4153-60. [PMID:
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Patterson-Bartlett J, Levin MJ,
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2007 Oct;25(41):7087-93. [PMID:
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Paul SM, Epstein J, Rao S, Williams F,
Freilich D, Luke T, Sedegah M,
de la Vega P, Sacci J, Richie T,
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Jul;196(1):145-54.
Pellissier JM, Brisson M, Levin MJ.
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Vaccine. 2007 Nov;25(49):8326-37.
[PMID: 17980938]
Perez-Velez CM, Anderson MS,
Robinson CC, McFarland EJ,
Nix WA, Pallansch MA, Oberste MS,
GlodГ© MP. Outbreak of neurologic
enterovirus type 71 disease: a
diaВ­gВ­nostic challenge. Clin Infect
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Quiambao BP, Simoes EA,
Ladesma EA, Gozum LS, Lupisan SP,
Sombrero LT, Romano V, Ruutu PJ.
Serious community-acquired
neonatal infections in rural
Southeast Asia (Bohol Island,
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Rao S, Todd J. Group A streptoВ­
cocВ­cal pharyngitis. Contagious
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Rotbart HA. Germ proof your kids:
Vaccines. Kids’ Pages Magazine.
2007 Dec.
Rotbart HA. The on deck circle of
life – 101 lessons from the dugout.
New York: iUniverse, Inc; 2007.
Sawyer MH, Rotbart HA. Aseptic
and viral meningitis. In: Long SS,
Prober CG, Pickering LK, editors.
Principles and practice of pediatric
infectious diseases. 3rd ed. New
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Schmader KE, Sloane R, Pieper C,
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Johnson G, Williams HM, Oxman MN.
The impact of acute herpes zoster
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Scott GM, Weinberg A,
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novel DNA polymerase mutations
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Antimicrob Agents Chemother.
2007 Jan;51(1):89-94.
Simoes EA. Maternal smoking,
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Simoes EA, Groothuis JR,
Carbonell-Estrany X, Rieger CH,
Mitchell I, Fredrick LM, Kimpen JL.
Palivizumab prophylaxis, respiratory syncytial virus, and subsequent
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Weinberg A, Leary JJ, Sarisky RT,
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Feb;38(2):139-45. [PMID: 17169605]
Weinberg A, Levin MJ. Infections:
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Weinberg A, Louzao R,
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Pinto JA, Huff MF, de Castro AC,
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2006-2008 Departmental Report
193
publications
Wong CW, Heng CL, Wan Yee L,
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Hibberd ML, Sung WK, Miller LD.
Optimization and clinical validation
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Murguia De Sierra T, Simoes EA,
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highly specific for patients with
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2006 Publications
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to diagnosis. Totowa: Humana Press;
2006.
Abzug MJ. Viral meningitis and
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Abzug MJ, Pelton SI, Song LY,
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Borkowsky W, Rosenblatt HM,
Marcinak JF, Dieudonne A,
Abrams EJ, Pathak I. ImmunoВ­
genicity, safety, and predictors of
response after a pneumococcal
conjugate and pneumococcal
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virus infection. Pediatrics. 2006
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Cowden J, Parker SK. Intravenous
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GlodГ© MP, Robinson CC, Holmes KV.
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Dominguez SR, Daum RS.
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Finnen RL, Mizokami KR, Banfield BW,
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van Burik J-AH, Raad I, Abzug MJ,
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Gonzalez CE, Revankar SG,
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Jesser RD, Li S, Weinberg A.
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HIV-infected individuals on HAART
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Levin MJ, Gershon AA, Weinberg A,
Song LY, Fentin T, Nowak B.
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current or past significant depression of CD4(+) T cells. J Infect Dis.
2006 Jul;194(2):247-55. [PMID:
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McFarland EJ, Johnson DC,
Muresan P, Fenton T, Tomaras GD,
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McFarland EJ, Smith S, Melvin A,
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Zeichner S. The scientific basis of
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Simoes EAF, Cherian T, Chow J,
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John TJ. Acute respiratory infections
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Stensballe LG, Kristensen K,
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Benn CS, Aaby P. Atopic disposition, wheezing, and subsequent
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Erice A, Hirsch MS, Polsky B.
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Kempe Center for the
Prevention and Treatment
of Child Abuse and Neglect
2008 Publications
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Jouriles EN, McDonald R, Slep AM,
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Mathews B, Bross DC. Mandated
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Sirotnak AP, Krugman RD,
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Stafford B, Hagman J, Dech B.
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Whitaker DJ, Lea B, Hanson K,
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Bross DC, Goldson E. The reality
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Brown A, Fitzgerald M, Shipman K,
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Deterding RR, Wong S, Faries G,
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Metzner JL. Introduction to:
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Shipman K, Schneider R,
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Sirotnak AP. Child abuse and
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Sirotnak AP. Non-accidental trauma
in the PICU: taking care of the
child, the family and ourselves.
Pediatric Critical Care National
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2006, Denver. Contemporary
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Sirotnak AP, Chiesa A. Child abuse
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Sirotnak AP, Krugman RD. Child
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Hay WW Jr, Levin M, Sondheimer J,
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Marconi AM, Ronzoni S, Bozzetti P,
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2008.
Philip AGS, Hay WW Jr,
Stevenson DK. Intrauterine growth
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Regnault TRH, Battaglia FC. Amino
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Reynolds RM, Bass KD, Thureen PJ.
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Rosenberg A. The IUGR newborn.
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Rozance PJ, Limesand SW, Barry JS,
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Hay WW Jr. Chronic late-gestation
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Tourneux P, Chester MA, Grover TR,
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Battaglia FC. Placental transport:
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Galan HL, Battaglia FC. FetoВ­
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Gien J, Seedorf GJ,
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Grover TR, Asikainen TM, Kinsella JP,
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Hay WW Jr. Nutrition and development of the fetus: carbohydrate
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Decker Inc; 2007.
Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric diagnosis
and treatment. 18th ed. New York:
McGraw Hill; 2007.
Hay WW Jr, Regnault TRH. Fetal
requirements and placental transfer
of nitrogenous compounds.
In: Polin RA, Fox WW, Abman SH,
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ology. 4th ed. Philadelphia:
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Hay WW Jr, Regnault TH, Brown LD.
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transfer of nitrogenous compounds.
In: Polin RA, Fox WW, Abman SH,
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Hay WW Jr, Thureen PJ. Indirect
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Hemachandra AH, Howards PP,
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Jozwik M, Jozwik M, Teng C,
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Kinsella JP, Abman SH. Inhaled nitric
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Kunig AM, Parker TA, Nogee LM,
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Lea RG, Wooding P, Stewart I,
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Limesand SW, Rozance PJ, Smith D,
Hay WW Jr. Increased insulin sensitivity and maintenance of glucose
utilization rates in fetal sheep with
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Physiol Endocrinol Metab. 2007 Dec;
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MacRitchie AN, Gardner AA,
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FASEB J. 2007:Apr;21(4):1164-76.
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Moore LG, Niermeyer S, Vargas E.
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Niermeyer S. Going to high altitude
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Payne VA, Au WS, Gray SL, Nora ED,
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Sequential regulation of diacylglycerol acyltransferase 2 expression by
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Rahman SM, Schroeder-Gloeckler JM,
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enhancing binding protein beta
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stress, and lipid accumulation
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steatohepatitis. Hepatology.
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2006-2008 Departmental Report
197
publications
Raiten DJ, Kalhan SC, Hay WW Jr.
Maternal nutrition and optimal
infant feeding practices: executive
summary. Am J Clin Nutr. 2007
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Regnault TR, de Vrijer B, Galan HL,
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Regnault TR, Kudo Y, Glazier J,
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Reynolds RM, Thureen PJ. Special
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Rahman SM, Janssen RC, Qiao L,
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O’Doherty RM, Becker TC,
Klemm DJ, Jensen DR, Pulawa LK,
Eckel RH, Friedman JE. CCAAT/
enhancer-binding protein beta
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Schroder J, Rahman SM, Shao J,
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McManaman JL, Gitomer WL,
Huang W, O’Doherty RM, Klemm DJ,
Friedman JE. Deletion of CCAAT/
enhancer-binding protein beta
(C/EBPbeta) reduces adiposity,
hepatic steatosis, and diabetes
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Rosenberg AA. The neonate. In:
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Southard A, Niermeyer S, Yaron M.
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High Alt Med Biol. 2007 Summer;
8(2):124-30. [PMID: 17584006]
Rozance PJ, Limesand SW, Zerbe GO,
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beta-cells. Am J Physiol Endocrinol
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Thilo EH, Rosenberg AA. The newborn infant. In: Hay WW Jr,
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Thureen PJ. The neonatologist’s
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Thureen PJ, Hay WW Jr. Nutritional
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Vargas M, Vargas E, Julian CG,
Armaza JF, Rodriguez A, Tellez W,
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Wallace JM, Milne JS, Aitken RP,
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Watterberg KL, Shaffer ML,
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Abbasi S, Cole CH, Aucott SW,
Thilo EH, Rozycki HJ, Lacy CB.
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Pediatrics. 2007 Jul;120(1):40-8.
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Wilson MJ, Lopez M, Vargas M,
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Bigham A, Armaza JF, Niermeyer S,
Shriver M, Vargas E, Moore LG.
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during pregnancy in multigenerational (Andean) than shorter-term
(European) high-altitude residents.
Am J Physiol Regul Integr Comp
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Ziebell BT, Galan HL, Anthony RV,
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Arroyo JA, Anthony RV, Parker TA,
Galan HL. Differential expression of
placental and vascular endothelial
nitric oxide synthase in an ovine
model of fetal growth restriction.
Am J Obstet Gynecol. 2006 Sep;
195(3):771-7. [PMID: 16875646]
Barry J, Thureen PJ. Nutritional
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Hay, WW Jr, editors. Neonatal
nutrition and metabolism. 2nd ed.
Cambridge: Cambridge University
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Barry JS, Davidsen ML, Limesand SW,
Galan HL, Friedman JE, Regnault TR,
Hay WW Jr. Developmental changes
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Barry JS, Thureen P. Nutrition in
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Brown LD, Hay WW Jr. Effect of
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Cavalli C, Teng C, Battaglia FC,
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de Vrijer B, Davidsen ML,
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mid-pregnancy. Pediatr Res. 2006
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publications
Fliman PJ, deRegnier RA, Kinsella JP,
Reynolds M, Rankin LL, Steinhorn RH.
Neonatal extracorporeal life support:
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J Pediatr. 2006 May;148(5):595-9.
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Friedman JE, editor. New transcription factors in diabetes and obesity
and its therapy. Amsterdam:
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Hay WW. Early postnatal nutritional
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Hay WW. Placental-fetal glucose
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Hay WW Jr. Recent observations on the regulation of fetal
metabolism by glucose. J Physiol.
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Hay WW Jr, Thureen PJ. Early postnatal administration of intravenous
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Huicho L, Niermeyer S. CardioВ­
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Jozwik M, Jozwik M, Teng C,
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and urea concentrations in human
pre-ovulatory ovarian follicular
fluid. Hum Reprod. 2006 Nov;21(11):
2776-82. [PMID: 16950828]
Kahn BF, Davies JK, Lynch AM,
Reynolds RM, Barbour LA. Predictors
of glyburide failure in the treatment
of gestational diabetes. Obstet
Gynecol. 2006 Jun; 107(6):1303-9.
[PMID: 16738156]
Kinsella JP. Inhaled nitric oxide
therapy in premature newborns.
Curr Opin Pediatr. 2006 Apr;18(2):
107-11. [PMID: 16601487]
Kinsella JP, Cutter GR, Walsh WF,
Gerstmann DR, Bose CL, Hart C,
Sekar KC, Auten RL, Bhutani VK,
Gerdes JS, George TN,
Southgate WM, Carriedo H,
Couser RJ, Mammel MC, Hall DC,
Pappagallo M, Sardesai S, Strain JD,
Baier M, Abman SH. Early inhaled
nitric oxide therapy in premature
newborns with respiratory failure.
N Engl J Med. 2006 Jul;355(4):
354-64. [PMID: 16870914]
Kinsella JP, Greenough A, Abman SH.
Bronchopulmonary dysplasia.
Lancet. 2006 Apr;367(9520):1421-31.
[PMID: 16650652]
Kunig AM, Balasubramaniam V,
Markham NE, Seedorf G, Gien J,
Abman SH. Recombinant human
VEGF treatment transiently increases lung edema but enhances lung
structure after neonatal hyperoxia.
Am J Physiol Lung Cell Mol Physiol.
2006 Nov;291(5):L1068-78. [PMID:
16829629]
Limesand SW, Rozance PJ,
Zerbe GO, Hutton JC, Hay WW Jr.
Attenuated insulin release and storage in fetal sheep pancreatic islets
with intrauterine growth restriction.
Endocrinology. 2006 Mar;147(3):
1488-97. [PMID: 16339204]
Marconi AM, Paolini CL, Zerbe G,
Battaglia FC. Lactacidemia in intrauterine growth restricted (IUGR)
pregnancies: relationship to clinical
severity, oxygenation and placental
weight. Pediatr Res. 2006 Apr;59(4
Pt 1):570-4. [PMID: 16549531]
McCurdy CE, Friedman JE. Early
foetal programming of hepatic
gluconeogenesis: glucocorticoids
strike back. Diabetologia. 2006
Jun;49(6):1138-41. [PMID: 16680490]
McMillan JA, DeAngelis CD,
Feigen RD, Jones MD Jr. Oski’s
Pediatrics. 4th edition. Philadelphia:
Lippincott Williams and Wilkins;
2006.
Meschia G. Indwelling plastic catheters in developmental physiology. Historical article. Am J Obstet
Gynecol. 2006 Apr;194(4):1197-9.
[PMID: 16580336]
Meschia G, Cotter JR, Breathnach CS,
Barron DH. The hemoglobin, oxygen, carbon dioxide and hydrogen
ion concentrations in the umbilical
blood of sheep and goats as sampled via indwelling plastic catheters.
1965. Classical Article, Am J Obstet
Gynecol. 2006 Apr;194(4):1196.
[PMID: 16580334]
Niermeyer S. Volume resuscitation: crystalloid versus colloid. Clin
Perinatol. 2006 Mar; 33(1):133-40,
viii. Review. [PMID: 16533639]
Paisley JE, Hinckley AF, O�Leary DR,
Kramer WC, Lanciotti RS,
Campbell GL, Hayes EB. West Nile
virus infection among pregnant
women in a northern Colorado
community, 2003 to 2004.
Pediatrics. 2006 Mar;117(3):814-20.
[PMID: 16510662]
Parker TA, Roe G, Grover TR,
Abman SH. Rho kinase activation
maintains high pulmonary vascular
resistance in the ovine fetal lung.
Am J Physiol Lung Cell Mol Physiol.
2006 Nov;291(5):L976-82. [PMID:
16815887]
Regnault TR, Hay WW Jr. In vivo
techniques for studying fetoplacental nutrient uptake, metabolism,
and transport. Methods Mol Med.
2006;122:207-24. [PMID: 16511983]
Reiter PD, Novak K, Valuck RJ,
Rosenberg AA, Fish D. Effect of a
closed drug-delivery system on the
incidence of nosocomial and catheter-related bloodstream infections
in infants. Epidemiol Infect. 2006
Apr;134(2):285-91. [PMID: 16490132]
Rozance PJ, Hay WW Jr. HypoВ­
glycemia in newborn infants:
Features associated with adverse
outcomes. Biol Neonate. 2006;
90(2):74-86. [PMID: 16534190]
Rozance PJ, Limesand SW,
Hay WW Jr. Decreased nutrientstimulated insulin secretion in
chronically hypoglycemic lategestation fetal sheep is due to
an intrinsic islet defect. Am J
Physiol Endocrinol Metab. 2006
Aug;291(2):E404-11. [PMID:
16569758]
Shroeder-Gloeckler JM, Rahman SM,
Friedman JE. In: Friedman JE, editor.
Hepatic CCAAT/ enhancer binding
protein ОІ: (C/EBPОІ): engineer of
diabetes, obesity, and inflammatory disease processes. Advances in
molecular and cellular endocrinology. Amsterdam: Elsevier; 2006.
Singhal N, Niermeyer S. Neonatal
resuscitation where resources
are limited. Clin Perinatol. 2006
Mar;33(1):219-28, x-xi. Review.
[PMID: 16533646]
Thureen PJ. Early aggressive nutrition in very preterm infants. 59th
Nestle Nutrition Workshop. Berlin,
Germany, April 2006. Basel: S Karger
AG; 2006.
Thureen P, Reece M, Rodden D,
Barbour L, Chappell J, Leitner JW,
Jones RO, Draznin B. Increased
farnesylation of p21-Ras and neonatal macrosomia in women with
gestational diabetes. J Pediatr. 2006
Dec;149(6):871-3. [PMID: 17137910]
Thureen PJ, Hay WW Jr, editors.
Neonatal nutrition and metabolism.
2nd ed. Cambridge: Cambridge
University Press; 2006.
Wallace JM, Luther JS, Milne JS,
Aitken RP, Redmer DA, Reynolds LP,
Hay WW Jr. Nutritional modulation
of adolescent pregnancy outcome –
a review. Placenta. 2006 Apr;27
Suppl A:S61-8. [PMID: 16442614]
Nephrology*
2008 Publications
Cadnapaphornchai MA, McFann K,
Strain JD, Masoumi A, Schrier RW.
Evidence of increased left ventricular mass index (LVMI) in ADPKD children with borderline hypertension.
Kidney Int. 2008 Nov;74(9):1192-6.
[PMID: 18716604]
Cadnapaphornchai MA, McFann K,
Strain JD, Masoumi A, Schrier RW.
Reliability and validity of magnetic
resonance imaging (MRI) for
assessment of progressive renal
cystic disease in pediatric autosomal
dominant polycystic kidney disease
(ADPKD). American Society of
Nephrology Annual Meeting;
2008 Nov 4-9; Philadelphia.
2006-2008 Departmental Report
199
publications
Denmen P, Kaufman J, Klein C,
Altmann C, Keniston A,
Cadnapaphornchai M, Faubel S.
Urine IL-6 is an early diomarker
of acute kidney injury (AKI) in mice
and patients. American Society
of Nephrology Annual Meeting;
2008 Nov 4-9; Philadelphia.
Dharnidharka VR, Talley LI, Martz KL,
Stablein DM, Fine RN. Recombinant
growth hormone use pretransplant
and risk for post-transplant lymphoВ­
proliferative disease – a report of
the NAPRTCS. Pediatr Transplant.
2008 Sep;12(6):689-95. [PMID:
18179637]
Elhassan E, Masoumi A,
Cadnapaphornchai MA, Yan XD,
Gitomer S, Reed-Gitomer B,
Schrier RW. Circulating angiopoietin
level is correlated with renal cyst
number in young ADPKD patients.
American Society of Nephrology
Annual Meeting; 2008 Nov 4-9;
Philadelphia.
Ellis EN, Martz K, Talley L, Ilyas M,
Pennington KL, Blaszak RT. Factors
related to long term renal transplant function in children. Pediatr
Nephrol. 2008;23(7):1149-55.
[PMID: 18301925]
Ford DM. Fluid, electrolyte, and
acid-base disorders and therapy.
In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric
diagnosis and treatment. 19th ed.
New York: McGraw Hill; 2009.
Gonzales R, Willoughby J, Ford DM,
Lum GM, Cadnapaphornchai MA.
Management of acute renal failure
and increased intracranial pressure
with CRRT. 5th International Pediatric
Continuous Renal Replacement
Therapy (CRRT) Conference; 2008
Jun 19-21; Orlando.
Lum GM. Kidney and urinary
tract. In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric
diagnosis and treatment. 19th ed.
New York: McGraw Hill; 2009.
Wisner B, Ford DM, Koyle MA.
The metabolic and endocrine
response to surgery II: management.
In: Wilcox DT, Godbole P, Koyle MA,
editors. Pediatric urology: surgical
complications and management.
Oxford, UK, Hoboken: WileyBlackwell Publishing; 2008.
2007 Publications
Cadnapaphornchai MA, McFann K,
Strain JD, Masoumi A, Schrier RW.
Relationship between blood pressure, renal volume, and left ventriВ­
cular mass in children with autosomal dominant polycystic kidney
disease (ADPKD). American Society
of Nephrology Annual Meeting,
2007 Oct 31-Nov 5; San Francisco.
Carey WA, Talley LI, Sehring SA,
Jaskula JM, Mathias RS. Outcomes of
dialysis initiated during the neonatal
period for treatment of end-stage
renal disease: a North American
Pediatric Renal Trials and collaborative studies special analysis.
Pediatrics. 2007 Feb;119(2):e468-73.
[PMID: 17224455]
Cheung CC, Cadnapaphornchai MA,
Ranadive SA, Gitelman SE,
Rosenthal SM. Persistent elevation
of urine aquaporin-2 during water
loading in a child with nephrogenic
syndrome of inappropriate (NSIAD).
The Endocrine Society’s 89th Annual
Meeting; 2007 June 2-5; Toronto,
Ontario, Canada.
Ford DM. Fluid, electrolyte, and
acid-base disorders and therapy.
In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric
diagnosis and treatment. 18th ed.
New York: McGraw Hill; 2007.
Friedman K, Wallis T, Maloney KW,
Hendrickson RJ, Mengshol S,
Cadnapaphornchai MA. An unusual
cause of pediatric hypertension.
J Pediatr. 2007 Aug;151(2):206-12.
[PMID: 17643780]
Goldstein SL, Mattoo TK,
Morgenstern B, Martz K, Stablein D,
Talley L. Anemia and growth status
in pediatric patients receiving
maintenance dialysis after a failed
renal transplant course: a NAPRTCS
report. Pediatr Transplant. 2007
Mar;11(2):201-4. [PMID: 17300501]
Lum GM. Kidney and urinary
tract. In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric
diagnosis and treatment. 18th ed.
New York: McGraw Hill; 2007.
2 00 D e p a r t m e n t o f P e d i a t r i c s
Omoloja A, Mitsnefes M, Talley L,
Benfield M, Neu A. Racial differences
in graft survival: a report from the
North American Pediatric Renal
Trials and Collaborative Studies
(NAPRTCS). Clin J Am Soc Nephrol.
2007 May;(3):524-8. [PMID:
17699460]
Puliyanda DP, Stablein DM,
Dharnidharka VR. Younger age
and antibody induction increase
the risk for infection in pediatric
renal transplantation: a NAPRTCS
report. Am J Transplant. 2007
Mar;7(3):662-6. [PMID: 17250558]
Seikaly MG, Salhab N, Warady BA,
Stablein D. Use of rhGH in children
with chronic kidney disease: lessons
from NAPRTCS. Pediatr Nephrol.
2007 Aug;22(8):1195-204. [PMID:
17530229]
Smith JM, Dharnidharka VR, Talley L,
Martz K, McDonald RA. BK virus
nephropathy in pediatric renal
transplant recipients: an analysis of
the North American Pediatric Renal
Trials and Collaborative Studies
(NAPRTCS) registry. Clin J Am Soc
Nephrol. 2007 Sep:2(5):1037-42.
Smith JM, Stablein DM, Munoz R,
Hebert D, McDonald RA. ContribuВ­
tions of the transplant registry:
the 2006 Annual Report of the
North American Pediatric Renal
Trials and Collaborative Studies
(NAPRTCS). Pediatr Transplant. 2007
Jun;11(4):366-73. [PMID: 17493215]
Szentirmai O, Winston KR, Jedlicka P,
Lum GM. Spontaneous intracerebral
hemorrhage in a child with systemic
hypertension and adrenal adenoma.
Case report. J Neurosurg. 2007
Oct;107(4 Suppl):328-9. [PMID:
17941500]
2006 Publications
Bunn A, Stablein DM, Hingorani SR,
McDonald RA. Long-term graft
survival in pediatric renal transplant patients based upon primary
disease: the NAPRTCS experience.
Transplantation. 2006;82(1Suppl
2):100.
Cadnapaphornchai MA, Chantler C.
Pediatric Nephrology. In: Schrier RW,
editor. Diseases of the kidney and
urinary tract. 8th ed. Philadelphia:
Lippincott Williams Wilkins; 2006.
Cadnapaphornchai P,
Cadnapaphornchai MA.
Nephrolithiasis. In: Hsu C-H, editor.
Calcium and phosphate metabolism
in chronic renal diseases. 1st ed.
New York: Springer; 2006.
Harmon W, Meyers K, Ingelfinger J,
McDonald R, McIntosh M, Ho M,
Spaneas L, Palmer JA, Hawk M,
Geehan C, Tinckham K, Hancock WW,
Sayegh MH. Safety and efficacy of
a calcineurin inhibitor avoidance
regimen in pediatric renal transplantation. J Am Soc Nephrol 2006
Jun;17(6):1735-45. [PMID: 16687625]
Li C, Wang W, Summer SN,
Cadnapaphornchai MA, Falk S,
Schrier RW. Molecular mechanism
for concentrating defect associated
with primary polydipsia. American
Society of Nephrology Annual MeetВ­
ing, 2006 Nov 14-19; San Diego.
Li C, Wang W, Summer SN,
Cadnapaphornchai MA, Falk S,
Umenishi F, Schrier RW. HyperВ­osВ­
molality in vivo upregulates aquaporin 2 water channel and Na-K-2Cl
co-transporter in Brattleboro rats.
J Am Soc Nephrol. 2006 Jun;17(6):
1657-64. [PMID: 16672318]
Seikaly MG, Salhab N, Gipson D,
Yiu V, Stablein D. Stature in children
with chronic kidney disease: analysis
of NAPRTCS database. Pediatr
Nephrol. 2006 Jun;21(6):793-9.
[PMID: 16583244]
Smith JM, Stablein D, Singh A,
Harmon W, McDonald RA.
Decreased risk of renal allograft
thrombosis associated with interВ­
leukin-2 receptor antagonists:
a report of the NAPRTCS. Am J
Transplant. 2006 Mar;6(3):585-8.
[PMID: 16468970]
Wang W, Li C, Summer SN, Falk S,
Cadnapaphornchai MA, Chen YC,
Schrier RW. Molecular analysis of
impaired urinary diluting capacity
in glucocorticoid deficiency. Am
J Physiol Renal Physiol. 2006 May;
290(5):F1135-42. [PMID: 16352742]
*Dr. Gary Lum’s publications are in
the citations associated with North
American Pediatric Renal Trials and
Collaborative Studies (NAPRTCS).
publications
Nutrition*
2008 Publications
Abebe Y, Bogale A, Hambidge KM,
Stoecker BJ, Arbide I, Teshome A,
Krebs NF, Westcott JE, Bailey KB,
Gibson RS. Inadequate intakes of
dietary zinc among pregnant women
from subsistence households in
Sidama, Southern Ethiopia. Public
Health Nutr. 2008 Apr;11(4): 379-86.
[PMID: 17610755]
Boles RE, Roberts MC. Supervising
children during parental distractions.
J Pediatr Psychol. 2008 Sep;33(8):
833-41. [PMID: 18334495]
Davis AM, Boles RE, James R,
Sullivan DK, Donnelly JE,
Swirczynski DL, Goetz J. Health
behaviors and weight status
among urban and rural children.
Rural Remote Health. 2007 Apr-Jun;
8(2):810. [PMID: 18426334]
Donahoo W, Wyatt HR, Kriehn J,
Stuht J, Dong F, Hosokawa P,
Grunwald GK, Johnson SL, Peters JC,
Hill JO. Dietary fat increases energy
intake across the range of typical
consumption in the United States.
Obesity. 2008 Jan;16(1):64-9. [PMID:
18223614]
Donnelly JE, Sullivan DK, Smith BK,
Jacobsen DJ, Washburn RA,
Johnson SL, Hill JO, Mayo MS,
Spaeth KR, Gibson C. Alteration of
dietary fat intake to prevent weight
gain: Jayhawk Observed Eating
Trial. Obesity. 2008 Jan;16(1):107-12.
[PMID: 18223621]
Gibson RS, Abebe Y, Stabler S,
Allen RH, Westcott JE, Stoecker BJ,
Krebs NF, Hambidge KM. Zinc,
gravida, infection, and iron, but not
vitamin B-12 or folate status, predict
hemoglobin during pregnancy in
Southern Ethiopia. J Nutr. 2008
Mar;138(3):581-6. [PMID: 18287370]
Hambidge KM, Miller LV,
Westcott JE, Krebs NF. Dietary
reference intakes for zinc may
require adjustment for phytate
intake based upon model predictions. J Nutr. 2008;138(12):2363-6.
[PMID: 19022958]
Jackman MR, Steig A, Higgins JA,
Johnson GC, Fleming-Elder BK,
Bessesen DH, MacLean PS.
Weight regain after sustained
weight reduction is accompanied
by suppressed oxidation of dietary
fat and adipocyte hyperplasia.
Am J Physiol Regul Integr Comp
Physiol. 2008 Apr;294(4):R1117-R29.
[PMID: 18287221]
Johnson SL, Clark L, Goree K,
O’Connor M, Zimmer LM. Healthcare
providers’ perceptions of the factors
contributing to infant obesity in
a low-income Mexican American
community. J Spec Pediatr Nurs.
2008 Jul;13(3):180-90. [PMID:
18638048]
Kim C, Haemer M, Krebs NF.
Parental and provider perceptions
of children’s weight status: where
and why the gaps. Obes Manag.
2008;4(5):236-41.
Krebs NF, Hambidge KM. Trace
elements in human nutrition. In:
Duggan C, Walker WA, Watkins JB,
editors. Nutrition in pediatrics: basic
science and clinical applications.
4th ed. Hamilton, Ontario: BC
Decker; 2008.
Krebs NF, Primak LE. Normal
childhood nutrition and its
disorders. In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric diagnosis
and treatment. 19th ed. New York:
McGraw Hill; 2009.
Sigman-Grant M, Christiansen E,
Branen L, Fletcher J, Johnson SL.
About feeding children: mealtimes
in child-care centers in four western states. J Am Diet Assoc. 2008
Feb;108(2):340-6. [PMID: 18237580]
2007 Publications
Abebe Y, Bogale A, Hambidge KM,
Stoecker BJ, Bailey K, Gibson RS.
Phytate, zinc, iron and calcium content of selected raw and prepared
foods consumed in rural Sidama,
Southern Ethiopia, and implications
for bioavailability. J Food Comp
Anal. 2007;20:161-8.
Hambidge KM, Krebs NF. Zinc
deficiency: a special challenge.
J Nutr. 2007 Apr;137(4):1101-5.
[PMID: 17374687]
Hambidge KM, Mazariegos M,
Solomons NW, Westcott JE, Lei S,
Raboy V, Grunwald G, Miller LV,
Sheng X, Krebs NF. Intestinal
excretion of endogenous zinc
in Guatemalan school children.
J Nutr. 2007 Jul;137(7):1747-9.
[PMID: 17585025]
Johnson SL, Bellows L, Beckstrom L,
Anderson J. Evaluation of a social
marketing campaign targeting preschool children. Am J Health Behav.
2007 Jan-Feb;31(1):44-55. [PMID:
17181461]
Krebs NF. Food choices to meet
nutritional needs of breast-fed
infants and toddlers on mixed diets.
J Nutr. 2007 Feb;137(2):511S-7S.
[PMID: 17237338]
Krebs NF. Meat as an early complementary food for infants: implications for macro- and micronutrient
intakes. Nestle Nutr Workshop Ser
Pediatr Program. 2007;60:221-9;
discussion 229-33. [PMID: 17664907]
Krebs NF. The use of zinc stable
isotopes to inform the dietary reference intake process for infants and
children. In: Suitor CW, Meyers LD,
editors. Dietary reference intakes
research synthesis; workshop summary. Washington, DC: The National
Academies Press; 2006. (Available
from www.nap.edu).
Krebs NF, Hambidge KM.
Complementary feeding: clinically
relevant factors affecting timing
and composition. Am J Clin Nutr.
2007 Feb;85(2):639S-45S. [PMID:
17284770]
Krebs NF, Himes JH, Jacobson D,
Nicklas TA, Guilday P, Styne D.
Assessment of child and adolescent
overweight and obesity. Pediatr.
2007 Dec;120 Suppl 4:S193-228.
[PMID: 18055652]
Krebs NF, Primak LE. Normal
childhood nutrition and its
disorders. In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric diagnosis
and treatment. 18th ed. New York:
McGraw Hill; 2007.
McClure EM, Wright LL,
Goldenberg RL, Goudar SS,
Parida SN, Jehan I, Tshefu A,
Chomba E, Althabe F, Garces A,
Harris H, Derman RJ, Panigrahi P,
Engmann C, Buekens P, Hambidge M,
Carlo WA. The Global Network: a
prospective study of stillbirths in
developing countries. Am J Obstet
Gynecol. 2007 Sep;197(3):e1-5.
[PMID: 17826406]
Miller LV, Krebs NF, Hambidge KM.
A mathematical model of zinc
absorption in humans as a function
of dietary zinc and phytate. J Nutr.
2007 Jan;137(1):135-41. [PMID:
17182814]
O�Brien CE, Krebs NF, Westcott JL,
Dong F. Relationships among
plasma zinc, plasma prolactin,
milk transfer, and milk zinc in lactating women. J Hum Lact. 2007
May;23(2):179-83. [PMID: 17478870]
2006 Publications
Belansky ES, Romaniello C, Morin C,
Uyeki T, Sawyer RL, Scarbro S,
Auld GW, Crane L, Reynolds K,
Hamman RF, Marshall JA. Adapting
and implementing a long-term
nutrition and physical activity curriculum to a rural, low-income,
biethnic community. J Nutr Educ
Behav. 2006 Mar-Apr;38(2):106-13.
[PMID: 16595289]
Drozd M, Romaniello C, Wearner R,
Carter V, Auld GW. Benefits of a
nutrition book bag program. J Nutr
Educ Behav. 2006 Jul-Aug;38(4):
259-61. [PMID: 16785097]
Eckel RH, Hernandez TL, Bell ML,
Weil KM, Shepard TY, Grunwald GK,
Sharp TA, Francis CC, Hill JO.
Carbohydrate balance predicts
weight and fat gain in adults. Am
J Clin Nutr. 2006 Apr;83(4):803-8.
[PMID: 16600931]
Greer FR, Krebs NF. Optimizing
bone health and calcium intakes of
infants, children, and adolescents.
Pediatr. 2006 Feb;117(2):578-85.
[PMID: 16452385]
Hambidge KM. Zinc and pneumonia.
Am J Clin Nutr. 2006 May;83(5):
991-2. [PMID: 16685039]
2006-2008 Departmental Report
201
publications
Hambidge KM, Abebe Y, Gibson RS,
Westcott JE, Miller LV, Lei S,
Stoecker BJ, Arbide I, Teshome A,
Bailey KB, Krebs NF. Zinc absorption during late pregnancy in rural
southern Ethiopia. Am J Clin Nutr.
2006 Nov;84(5):1102-6. [PMID:
17093163]
Hambidge KM, Krebs NF,
Westcott JE, Miller LV. Changes in
zinc absorption during development. J Pediatr. 2006 Nov;149
(5 Suppl):S64-8. [PMID: 17212960]
Hubbs-Tait L, Nation J, Krebs NF,
Bellinger D. Neurotoxicants, micronutrients, and social environments:
individual and combined effects
on children�s development. Psychol
Sci Public Interest. 2006;6:57-121.
Johnson SL, Taylor-Holloway LA.
Non-Hispanic white and Hispanic
elementary school children�s selfregulation of energy intake. Am J
Clin Nutr. 2006 Jun;83(6):1276-82.
[PMID: 16762937]
Keller KL, Pietrobelli A, Johnson SL,
Faith MS. Maternal restriction of
children�s eating and encouragements to eat as the �non-shared
environment�: a pilot study using
the child feeding questionnaire.
Int J Obes. 2006 Nov;30(11):1670-5.
[PMID: 16568136]
Krebs NF, Primak LE. Comprehensive
integration of nutrition into medical
training. Am J Clin Nutr. 2006 Apr;
83(4):945S-50S. [PMID: 16600953]
Krebs NF, Sothern MS. Clinical
evaluation: diagnosis, medical testing, and follow-up. In: Sothern M,
Gordon ST, vonAlmen TK, editors.
Handbook of pediatric obesity: clinical management. Boca Raton, FL:
CRC Press; 2006.
Krebs NF, Westcott JE, Butler N,
Robinson C, Bell M, Hambidge KM.
Meat as a first complementary food
for breastfed infants: feasibility and
impact on zinc intake and status.
J Pediatr Gastroenterol Nutr. 2006
Feb;42(2):207-14. [PMID: 16456417]
Krebs NF, Westcott JL, Rodden DJ,
Ferguson KW, Miller LV,
Hambidge KM. Exchangeable
zinc pool size at birth is smaller in
small-for-gestational-age than in
appropriate-for-gestational-age preterm infants. Am J Clin Nutr. 2006
Dec;84(6):1340-3. [PMID: 17158414]
Mayes S, Roberts MC, Boles RE,
Brown KJ. Children�s knowledge
of household safety rules. Child
Health Care. 2006;35(3):269-80.
Mazariegos M, Hambidge KM,
Krebs NF, Westcott JE, Lei S,
Grunwald GK, Campos R,
Barahona B, Raboy V, Solomons NW.
Zinc absorption in Guatemalan
schoolchildren fed normal or lowphytate maize. Am J Clin Nutr. 2006
Jan;83(1):59-64. [PMID: 16400050]
Sheng XY, Hambidge KM, Zhu XX,
Ni JX, Bailey KB, Gibson RS, Krebs NF.
Major variables of zinc homeostasis
in Chinese toddlers. Am J Clin Nutr.
2006 Aug;84(2):389-94. [PMID:
16895888]
*Dr. James Hill’s publications are
listed under the Center for Human
Nutrition.
Pediatric Hospital Medicine
2008 Publications
Seltz B. A green case of failure to
thrive. Paediatrics and Child Health
2008;13:685-7.
Zandieh S, Yoon-Flannery K,
Kuperman GJ, Hyman D,
Kaushala R. Correlates of expected
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Friedman NR. Polysomnography
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Zeitlin P, Hiatt P, Moss R, Williams J,
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Gien J, Seedorf GJ,
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Grover TR, Asikainen TM, Kinsella JP,
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Guilbert TW, Morgan WJ, Zeiger RS,
Mauger DT, Boehmer SJ, Szefler SJ,
Bacharier LB, Lemanske RF Jr,
Strunk RC, Allen DB, Bloomberg GR,
Heldt G, Krawiec M, Larsen G,
Liu AH, Chinchilli VM, Sorkness CA,
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McGinley BM. Childhood obstructive
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Harris JK, De Groote MA, Sagel SD,
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Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric
diagnosis and treatment. 18th ed.
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Hirsch J, Hansen KC, Sapru A,
Frank JA, Chalkley RJ, Fang X,
Trinidad JC, Baker P, Burlingame AL,
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2007 May;175(10):1006-13. [PMID:
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Hunsucker SW, Accurso FJ,
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Jordan JR, Moore EE, Damle SS,
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Kang JB, Rothenberg SS, Krawiec ME,
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Kerby GS, Accurso FJ, Deterding RR,
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Kinsella JP, Abman SH. Inhaled
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Konstan MW, Morgan WJ, Butler SM,
Pasta DJ, Craib ML, Silva SJ,
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Kunig AM, Parker TA, Nogee LM,
Abman SH, Kinsella JP. ABCA3
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Larsen G. In my opinion – interview
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Larsen GL, Loader K, Fratelli C,
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Lee RL, White CW. Bronchiolitis
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Mayer-Hamblett N, Aitken ML,
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Mayer-Hamblett N, Aitken ML,
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McDermott RA, Porterfield HS,
El Mezayen R, Burks AW, Pons L,
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Moss RB, Milla C, Colombo J,
Accurso F, Zeitlin PL, Clancy JP,
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Dorkin HL, Ferkol T, Pian M,
Ramsey B, Carter BJ, Martin DB,
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Gene Ther. 2007 Aug;18(8):726-32.
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Padman R, McColley SA, Miller DP,
Konstan MW, Morgan WJ,
Schechter MS, Ren CL, Wagener JS.
Infant care patterns at epidemiВ­
ologic study of cystic fibrosis sites
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Rancourt RC, Lee RL, O’Neill H,
Accurso FJ, White CW. Reduced
thioredoxin increases pro-inflammatory cytokines and neutrophil
influx in rat airways: modulation by
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2007 May;42(9):1441-53. [PMID:
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Ren CL, Morgan WJ, Konstan MW,
Schechter MS, Wagener JS,
Fisher KA, Regelmann WE.
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Staphylococcus aureus in respiratory cultures from cystic fibrosis
patients is associated with lower
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2007 Jun;42(6):513-8. [PMID:
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Rowe SM, Accurso F, Clancy JP.
Detection of cystic fibrosis transmembrane conductance regulator activity in early-phase clinical
trials. Proc Am Thorac Soc. 2007
Aug;4(4):387-98. [PMID: 17652506]
Sagel SD. An infant in our practice
has an initial CF newborn screen is
that is positive. What do I do and
what do I tell the family? What is
the likelihood this patient has CF?
Children’s Link: Clinical Corner:
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questions. 2007 May;5(3).
Sagel SD, Chmiel JF, Konstan MW.
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Siparsky G, Accurso FJ. Chemistry
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Slifer KJ, Kruglak D, Benore E,
Bellipanni K, Falk L, Halbower AC,
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Behav Sleep Med. 2007;5(2):147-75.
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Sorkness CA, Lemanske RF Jr,
Mauger DT, Boehmer SJ,
Chinchilli VM, Martinez FD,
Strunk RC, Szefler SJ, Zeiger RS,
Bacharier LB, Bloomberg GR,
Covar RA, Guilbert TW, Heldt G,
Larsen G, Mellon MH, Morgan WJ,
Moss MH, Spahn JD, Taussig LM.
Long-term comparison of three
controller regimens for mildmoderate persistent childhood
asthma: the Pediatric Asthma
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Spahn JD, Krawiec ME. Safety of
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Spahn JD, Krawiec ME. Safety of
asthma pharmacotherapy: Part 2.
Corticosteroids and leukotriene
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2007;8(5).
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Tang JR, Seedorf G,
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Thebaud B, Abman SH.
Bronchopulmonary dysplasia:
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2006 Publications
Abman SH. Fifty years ago in the
Journal of Pediatrics. Pulmonary
endarteritis with cor pulmonale in
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Abman SH. Pulmonary hypertension
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Accurso FJ. Update in cystic fibrosis
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Ahmad A, Ahmad S, Chang L-Y,
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Ahmad S, Ahmad A, Schneider KB,
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Ahmad S, Ahmad A, White CW.
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Asikainen TM, Chang L-Y,
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Asikainen TM, Schneider BK,
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Balasubramaniam V, Maxey AM,
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[PMID: 16399787]
Balasubramaniam V, Maxey AM,
Morgan DB, Markham NE, Abman
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Am J Physiol Lung Cell Mol Physiol.
2006 Jul;291(1):L119-27. [PMID:
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Borowitz D, Goss CH, Stevens C,
Hayes D, Newman L, O’Rourke A,
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Young KR Jr, Dunitz J, Murray FT.
Safety and preliminary clinical
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Pancreas. 2006 Apr;32(3):258-63.
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Cavanaugh KL, Friedman NR.
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Deruelle P, Balasubramaniam V,
Kunig AM, Seedorf GJ, Markham NE,
Abman SH. BAY 41-2272, a direct
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Deterding R. How to evaluate and
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Friedman NR, McCormick DP,
Pittman C, Chonmaitree T,
Teichgraeber DC, Uchida T,
Baldwin CD, Saeed KA. DevelopВ­
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Pediatr Infect Dis J. 2006 Feb;25(2):
101-7. [PMID: 16462284]
Guilbert TW, Morgan WJ, Zeiger RS,
Mauger DT, Boehmer SJ, Szefler SJ,
Bacharier LB, Lemanske RF Jr,
Strunk RC, Allen DB, Bloomberg GR,
Heldt G, Krawiec M, Larsen G,
Liu AH, Chinchilli VM, Sorkness CA,
Taussig LM, Martinez FD. Long-term
inhaled corticosteroids in preschool
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Halbower AC, Degaonkar M,
Barker PB, Earley CJ, Marcus CL,
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Halbower AC, Mahone EM. NeuroВ­
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Hirsch J, Hansen KC, Choi S, Noh J,
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Kamin CS, O’Sullivan P,
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Pediatrics. 2006 Sep;118(3):
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Kaye CI, Accurso F, La Franchi S,
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Schaefer GB. Introduction to the
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Pediatrics. 2006 Sep;118(3):
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Kids playing in the Boettcher Atrium at The Children’s Hospital
2006-2008 Departmental Report
207
publications
Kinsella JP, Cutter GR, Walsh WF,
Gerstmann DR, Bose CL, Hart C,
Sekar KC, Auten RL, Bhutani VK,
Gerdes JS, George TN,
Southgate WM, Carriedo H,
Couser RJ, Mammel MC, Hall DC,
Pappagallo M, Sardesai S, Strain JD,
Baier M, Abman SH. Early inhaled
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N Engl J Med. 2006 Jul;355(4):
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Kinsella JP, Greenough A, Abman SH.
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Kline C, Krupski T. Infant and toddler
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Kunig AM, Balasubramaniam V,
Markham NE, Seedorf G, Gien J,
Abman SH. Recombinant human
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2006 Nov;291(5):L1068-78. [PMID:
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Larsen GL, Fratelli C, Loader J,
Kang JK, Dakhama A. NeuropepВ­
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Larsen GL, Loader JE, Fratelli C,
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Ley RE, Harris JK, Wilcox J, Spear JR,
Miller SR, Bebout BM, Maresca JA,
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Unexpected diversity and complexity of the Guerrero Negro hypersaline microbial mat. Appl Environ
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Lin SY, Halbower AC, Tunkel DE,
Vanderkolk C. Relief of upper airway
obstruction with mandibular distraction surgery: Long-term quantiВ­
tative results in young children.
Arch Otolaryngol Head Neck Surg.
2006 Apr;132(4):437-41. [PMID:
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Marcus CL, Rosen G, Ward SL,
Halbower AC, Sterni L, Lutz J,
Stading PJ, Bolduc D, Gordon N.
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of positive airway pressure therapy
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McMullen AH, Pasta DJ,
Frederick PD, Konstan MW,
Morgan WJ, Schechter MS,
Wagener JS. Impact of pregnancy
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Chest. 2006 Mar;129(3):706-11.
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Merenstein D, Diener-West M,
Halbower AC, Krist A, Rubin HR.
The trial of infant response to
diphenhydramine: the TIRED
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Adolesc Med. 2006 Jul;160(7):
707-12. [PMID: 16818836]
Montgomery GS, Sagel SD,
Taylor AL, Abman SH. Effects of
sildenafil on pulmonary hyperВ­
tension and exercise tolerance in
severe cystic fibrosis-related lung
disease. Pediatr Pulmonol. 2006
Apr;41(4):383-5. [PMID: 16479610]
Morgan W, Guilbert T, Larsen GL.
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Francis; 2006.
Panayiotidis MI, Rancourt RC,
Pappa A, White CW. Effect of cell
cycle growth arrest on global
DNA methylation status in human
lung epithelial-like (A549) cells.
In Vivo. 2006 Nov-Dec;20(6B):
861-5. [PMID: 17203780]
Panayiotidis MI, Stabler SP,
White CW. Activation of a novel
isoform of methionine adenosyl
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S-adenosylmethionine turnover
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2006 Jan;40(2):348-58. [PMID:
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2 08 D e p a r t m e n t o f P e d i a t r i c s
Parker TA, Roe G, Grover TR,
Abman SH. Rho kinase activation
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Am J Physiol Lung Cell Mol Physiol.
2006 Nov;291(5):L976-82. [PMID:
16815887]
Sontag MK, Corey M, Hokanson JE,
Marshall JA, Sommer SS, Zerbe GO,
Accurso FJ. Genetic and physiologic
correlates of longitudinal immunoВ­
reactive trypsinogen decline in
infants with cystic fibrosis identified through newborn screening.
J Pediatr. 2006 Nov;149(5):650-7.
[PMID: 17095337]
Swiercz W, Cios KJ, Staley K,
Kurgan L, Accurso F, Sagel S.
A new synaptic plasticity rule
for networks of spiking neurons.
IEEE Trans Neural Netw. 2006 Jan;
17(1):94-105. [PMID: 16526479]
To T, Dell S, Dick PT, Cicutto L,
Harris JK, MacLusky IB, Tassoudji M.
Case verification of children with
asthma in Ontario. Pediatr Allergy
Immunol. 2006 Feb;17(1):69-76.
[PMID: 16426258]
Walsh MC, Szefler S, Davis J, Allen M,
Van Marter L, Abman S, Blackmon L,
Jobe A. Summary proceedings from
the bronchopulmonary dysplasia
group. Pediatrics. 2006 Mar;117
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White CW. Commentary on
“Hypoxia, hypoxic signaling, tissue
damage, and detection of reactive
oxygen species (ROS)”. Free Radic
Biol Med. 2006 Mar;40(6):923-7.
[PMID: 16540387]
Zeiger RS, Szefler SJ, Phillips BR,
Schatz M, Martinez FD, Chinchilli VM,
Lemanske RF Jr, Strunk RC,
Larsen G, Spahn JD, Bacharier LB,
Bloomberg GR, Guilbert TW,
Heldt G, Morgan WJ, Moss MH,
Sorkness CA, Taussig LM. Response
profiles to fluticasone and monВ­
telukast in mild-to-moderate persistent childhood asthma. J Allergy
Clin Immunol. 2006;117(1):45-52.
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programs
Center for Bioengineering
2008 Publications
Adzima BJ, Aguirre HA, Kloxin CJ,
Scott TF, Bowman CN. Rheological
and chemical analysis of reverse
gelation in a covalently crosslinked
Diels-Alder polymer network.
Macromolecules. 2008;41(23):
9112-7.
Hunter KS, Gross JK, Lanning CJ,
Kirby KS, Dyer KL, Ivy DD,
Shandas R. Noninvasive methods
for determining pulmonary vascular
function in children with pulmonary
arterial hypertension: application
of a mechanical oscillator model.
Congenit Heart Dis. 2008 Mar;3(2):
106-16. [PMID: 18380759]
Hunter KS, Lee PF, Lanning CJ,
Ivy DD, Kirby KS, Claussen LR,
Chan KC, Shandas R. Pulmonary
vascular input impedance is a
combined measure of pulmonary
vascular resistance and stiffness
and predicts clinical outcomes
better than pulmonary vascular
resistance alone in pediatric
patients with pulmonary hypertension. Am Heart J. 2008 Jan;
155(1):166-74. [PMID: 18082509]
Lammers SR, Kao PH, Qi HJ,
Hunter K, Lanning C, Albietz J,
Hofmeister S, Mecham R,
Stenmark KR, Shandas R. Changes
in the structure-function relationship of elastin and its impact on
the proximal pulmonary arterial
mechanics of hypertensive calves.
Am J Physiol Heart Circ Physiol.
2008 Oct;295(4):H1451-9. [PMID:
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Tan W, Scott D, Belchenko D, Qi HJ,
Xiao L. Development and evaluation of microdevices for studying
anisotropic biaxial cyclic stretch on
cells. Biomed Microdevices. 2008
Dec;10(6):869-82. [PMID: 18563571]
2007 Publications
Hunter KS, Lee PF, Lanning CJ,
Ivy DD, Kirby KS, Claussen LR,
Chan KC, Shandas R. Pulmonary
vascular input impedance is a
combined measure of pulmonary
vascular resistance and stiffness and
predicts clinical outcomes better
than pulmonary vascular resistance
alone in pediatric patients with
pulmonary hypertension. Am Heart
J. 2008 Jan;155(1):166-74. [PMID:
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publications
Tan W, Vinegoni C, Norman JJ,
Desai TA, Boppart SA. Imaging
cellular responses to mechanical
stimuli within three-dimensional
tissue constructs. Microsc Res Tech.
2007 Apr;70(4):361-71. [PMID:
17262787]
Yakacki CM, Shandas R, Lanning C,
Rech B, Eckstein A, Gall K. UnconВ­
strained recovery characterization
of shape-memory polymer networks
for cardiovascular applications. BioВ­
materials. 2007 May;28(14):2255-63.
[PMID: 17296222]
Zhang Y, Dunn ML, Hunter KS,
Lanning C, Ivy DD, Claussen L,
Chen SJ, Shandas R. Application of a
microstructural constitutive model
of the pulmonary artery to patientspecific studies: validation and
effect of orthotropy. J Biomech Eng.
2007 Apr;129(2):193-201. [PMID:
17408324]
2006 Publications
Dyer K, Lanning C, Das B, Lee PF,
Ivy DD, Valdes-Cruz L, Shandas R.
Noninvasive Doppler tissue measurement of pulmonary artery
compliance in children with pulmonary hypertension. J Am Soc
Echocardiogr. 2006 Apr;19(4):
403-12. [PMID: 16581479]
Dyer KL, Pauliks LB, Das B,
Shandas R, Ivy D, Shaffer EM,
Valdes-Cruz LM. Use of myocardial
performance index in pediatric
patients with idiopathic pulmonary
arterial hypertension. J Am Soc
Echocardiogr. 2006 Jan;19(1):21-7.
[PMID: 16423665]
Hunter KS, Lanning CJ, Chen SY,
Zhang Y, Garg R, Ivy DD, Shandas R.
Simulations of congenital septal
defect closure and reactivity testing
in patient-specific models of the
pediatric pulmonary vasculature:
A 3D numerical study with fluidstructure interaction. J Biomech
Eng. 2006 Aug;128(4):564-72.
[PMID: 16813447]
Hunter KS, Lanning CJ, Zhang Y,
Garg R, Ivy DD, Shandas R. SimulaВ­
tions of congenital defect closure
and drug reactivity testing in
patient-specific models of the
pediatric pulmonary vasculature:
a 3-D numerical study with fluidstructure interaction. J Biomech
Engr. 2006;128(4):564-72.
Ko HJ, Tan W, Stack R, Boppart SA.
Optical coherence elastography of
engineered and developing tissue.
Tissue Eng. 2006 Jan;12(1):63-73.
[PMID: 16499443]
Scott TF, Draughon RB, Bowman CN.
Actuation in crosslinked polymers
via photoinduced stress relaxation.
Adv Mater. 2006;18(16):2128-32.
Tan W, Oldenburg AL, Norman JJ,
Desai TA, Boppart SA. Optical coherence tomography of cell dynamics
in three-dimensional tissue models.
Opt Expr. 2006;14(16):7159-71.
Vinegoni C, Ralston TS, Tan W,
Luo W, Marks DL, Boppart SA.
Integrated structural and functional
optical imaging combining spectraldomain optical coherence and
multiphoton microscopy. Appl Phys
Lett. 2006;88(5):1-4.
Wang R, Lacour-Gayet FG,
Lanning CJ, Rech BA, Kilfoil PJ,
Hertzberg J, Shandas R. Initial
experience with the development
and numerical and in vitro studies
of a novel low-pressure artificial
right ventricle for pediatric Fontan
patients. ASAIO J. 2006 Nov-Dec;
52(6):682-92. [PMID: 17117059]
Xu C, Vinegoni C, Ralston TS, Luo W,
Tan W, Boppart SA. Spectroscopic
spectral-domain optical coherence
microscopy. Opt Lett. 2006 Apr;
31(8):1079-81. [PMID: 16625909]
Zheng H, Barker A, Shandas R.
Predicting backscatter characterВ­
istics from micron- and submicronscale ultrasound contrast agents
using a size-integration technique.
IEEE Trans Ultrason Ferroelectr Freq
Control. 2006 Mar;53(3):639-44.
[PMID: 16555773]
Zheng H, Liu L, Williams L,
Hertzberg J, Lanning C, Shandas R.
Real time multi-component echo
particle image velocimetry techВ­
nique for opaque flow imaging.
Appl Physics Letters. 2006;88(26):
261915.
Zheng H, Mukdadi O, Shandas R.
Theoretical predictions of harmonic
generation from submicron ultrasound contrast agents for nonlinear
biomedical ultrasound imaging.
Phys Med Biol. 2006 Feb;51(3):
557-73. [PMID: 16424581]
Center for Human Nutrition
2008 Publications
Bray GA, Jablonski KA, Fujimoto WY,
Barrett-Connor E, Haffner S,
Hanson RL, Hill JO, Hubbard V,
Kriska A, Stamm E, Pi-Sunyer FX,
Diabetes Prevention Program
Research Group. Relation of central
adiposity and body mass index to
the development of diabetes in
the Diabetes Prevention Program.
Am J Clin Nutr. 2008 May;87(5):
1212-8. [PMID: 18469241]
Catenacci VA, Ogden LG, Stuht J,
Phelan S, Wing RR, Hill JO, Wyatt HR.
Physical activity patterns in the
National Weight Control Registry.
Obesity. 2008 Jan;16(1):153-61.
[PMID: 18223628]
Donahoo W, Wyatt HR, Kriehn J,
Stuht J, Dong F, Hosokawa P,
Grunwald GK, Johnson SL, Peters JC,
Hill JO. Dietary fat increases energy
intake across the range of typical
consumption in the United States.
Obesity. 2008 Jan;16(1):64-9.
[PMID: 18223614]
Donnelly JE, Sullivan DK, Smith BK,
Jacobsen DJ, Washburn RA,
Johnson SL, Hill JO, Mayo MS,
Spaeth KR, Gibson C. Alteration of
dietary fat intake to prevent weight
gain: Jayhawk Observed Eating Trial.
Obesity. 2008 Jan;16(1):107-12.
[PMID: 18223621]
DuBose KD, Mayo MS, Gibson CA,
Green JL, Hill JO, Jacobsen DJ,
Smith BK, Sullivan DK, Washburn RA,
Donnelly JE. Physical activity across
the curriculum (PAAC): rationale and
design. Contemp Clin Trials. 2008
Jan;29(1):83-93. [PMID: 17611168]
Hill JO, Peters JC, Catenacci VA,
Wyatt HR. International strategies
to address obesity. Obes Reviews.
2008 Mar;9 Suppl 1:41-7. Review.
[PMID: 18307698]
Jackman MR, Steig A, Higgins JA,
Johnson GC, Fleming-Elder BK,
Bessesen DH, MacLean PS. Weight
regain after sustained weight
reduction is accompanied by suppressed oxidation of dietary fat
and adipocyte hyperplasia. Am J
Physiol Regul Integr Comp Physiol.
2008 Apr;294(4):R1117-29. [PMID:
18287221]
Jensen DR, Knaub LA, Konhilas JP,
Leinwand LA, MacLean PS, Eckel RH.
Increased thermoregulation in
cold-exposed transgenic mice overВ­
expressing lipoprotein lipase in
skeletal muscle: an avian phenoВ­
type? J Lipid Res. 2008 Apr;49(4):
870-9. [PMID: 18175800]
Lanningham-Foster L, Foster RC,
McCrady SK, Manohar CU,
Jensen TB, Mitre NG, Hill JO,
Levine JA. Changing the school
environment to increase physical activity in children. Obesity.
2008 Aug;16(8):1849-53. [PMID:
18535550]
LeCheminant JD, Jacobsen DJ,
Bailey BW, Mayo MS, Hill JO,
Smith BK, Donnelly JE. Effects of
long-term aerobic exercise on
EPOC. Int J Sports Med. 2008 Jan;
29(1):53-8. [PMID: 17879880]
Moore AF, Jablonski KA, McAteer JB,
Saxena R, Pollin TI, Franks PW,
Hanson RL, Shuldiner AR,
Knowler WC, Altshuler D, Florez JC,
Diabetes Prevention Program
Research Group. Extension of type 2
diabetes genome-wide association
scan results in the diabetes prevention program. Diabetes. 2008
Sep;57(9):2503-10. [PMID: 18544707]
Sazonov E, Schuckers S,
Lopez-Meyer P, Makeyev O,
Sazonova N, Melanson EL,
Neuman M. Non-invasive moniВ­
toring of chewing and swallowing
for objective quantification of ingestive behavior. Physiol Meas. 2008
May;29(5):525-41 [PMID: 18427161]
Wolf AM, Finer N, Allshouse AA,
Pendergast KB, Sherrill BH,
Caterson I, Hill JO, Aronne LJ,
Hauner H, Radigue C, Amand C,
Despres JP. PROCEED: Prospective
Obesity Cohort of Economic EvaluВ­
ation and Determinants: baseline
health and healthcare utilization
of the US sample. Diabetes Obes
Metab. 2008 Aug 20. [PMID:
18721258]
Wyatt HR, Jortberg BT, Babbel C,
Garner S, Dong F, Grunwald GK,
Hill JO. Weight loss in a community
initiative that promotes decreased
energy intake and increased physical activity and dairy consumption:
Calcium Weighs-In. J Phys Act
Health. 2008 Jan;5(1):28-44. [PMID:
18209252]
2006-2008 Departmental Report
209
publications
2007 Publications
Butryn ML, Phelan S, Hill JO,
Wing RR. Consistent self-monitoring
of weight: a key component of successful weight loss maintenance.
Obesity. 2007 Dec;15(12):3091-6.
[PMID: 18198319]
Catenacci VA, Wyatt HR. America
on the move. Med Clin North Am.
2007 Nov;91(6):1079-89, viii. Review.
[PMID: 17964910]
Catenacci VA, Wyatt HR. The role of
physical activity in producing and
maintaining weight loss. Nat Clin
Pract Endocrinol Metab. 2007 Jul;
3(7):518-29. Review. [PMID:
17581621]
Fujimoto WY, Jablonski KA,
Bray GA, Kriska A, Barrett-Connor E,
Haffner S, Hanson R, Hill JO,
Hubbard V, Stamm E, Pi-Sunyer FX.
Diabetes Prevention Program
Research Group. Body size and
shape changes and the risk of
diabetes in the diabetes prevention program. Diabetes. 2007 Jun;
56(6):1680-5. [PMID: 17363740]
Haugen HA, Tran ZV, Wyatt HR,
Barry MJ, Hill JO. Using telehealth
to increase participation in weight
maintenance programs. Obesity.
2007 Dec;15(12):3067-77. [PMID:
18198316]
Heber D, Seeram NP, Wyatt H,
Henning SM, Zhang Y, Ogden LG,
Dreher M, Hill JO. Safety and antioxidant activity of a pomegranate
ellagitannin-enriched polyphenol
dietary supplement in overweight
individuals with increased waist
size. J Agric Food Chem. 2007 Nov;
55(24):10050-4. [PMID: 17966977]
Hill JO. Understanding and addressing the epidemic of obesity: an
energy balance perspective. Endocr
Rev. 2007;27:750-61. [PMID:
17122359]
Hill JO, Peters JC, Wyatt HR. The role
of public policy in treating the
epidemic of global obesity. Clin
Pharmacol Ther. 2007 May;81(5):
772-5. Review. [PMID: 17314927]
Hill JO, Peters JC, Wyatt HR. The
role of public policy in treating
the epidemic of global obesity.
Clinical pharmacology & therapeutics. Public Policy. London: Nature
Publishing Group; 2007 Feb;1-4.
Hill JO, Wyatt HR, Phelan S,
Wing R. Lesson learned from the
National Weight Control Registry.
In: Kushner RF, Bessesen DH,
editors. Contemporary endocrinВ­
ology (series): treatment of the
obese patient. Hoboken: Springer/
Humana Press; 2007.
Le DS, Pannacciulli N, Chen K,
Salbe AD, Del Parigi A, Hill JO,
Wing RR, Reiman EM, Krakoff J.
Less activation in the left dorsolateral prefrontal cortex in the reanalysis
of the response to a meal in obese
than in lean women and its association with successful weight loss.
Am J Clin Nutr. 2007 Sep;86(3):
573-9. [PMID: 17823419]
Leibowitz KL, Chang GQ, Pamy PS,
Hill JO, Gayles EC, Leibowitz SF.
Weight gain model in prepubertal
rats: prediction and phenotyping of obesity-prone animals at
normal body weight. Int J Obes.
2007 Aug;31(8):1210-21. [PMID:
17471301]
Look AHEAD Research Group,
Pi-Sunyer X, Blackburn G,
Brancati FL, Bray GA, Bright R,
Clark JM, Curtis JM, Espeland MA,
Foreyt JP, Graves K, Haffner SM,
Harrison B, Hill JO, Horton ES,
Jakicic J, Jeffery RW, Johnson KC,
Kahn S, Kelley DE, Kitabchi AE,
Knowler WC, Lewis CE,
Maschak-Carey BJ, Montgomery B,
Nathan DM, Patricio J, Peters A,
Redmon JB, Reeves RS, Ryan DH,
Safford M, Van Dorsten B,
Wadden TA, Wagenknecht L,
Wesche-Thobaben J, Wing RR,
Yanovski SZ. Reduction in weight
and cardiovascular disease risk
factors in individuals with type 2
diabetes: one-year results of the
look AHEAD trial. Diabetes Care.
2007 Jun;30(6):1374-83. [PMID:
17363746]
Maclean PS, Tait RC. Hereditary and
acquired antithrombin deficiency:
epidemiology, pathogenesis and
treatment options. Drugs. 2007;
67(10):1429-40. Review. [PMID:
17600391]
Sullivan PW, Ghushchyan V,
Wyatt HR, Hill JO. The medical
cost of cardiometabolic risk factor
clusters in the United States.
Obesity. 2007 Dec;15(12):3150-8.
[PMID: 18198326]
Melanson EL, Donahoo WT,
Grunwald GK, Schwartz R. Changes
in 24-h substrate oxidation in older
and younger men in response to
exercise. J Appl Physiol. 2007 Nov;
103(5):1576-82. [PMID: 17717111]
Sullivan PW, Ghushchyan V,
Wyatt HR, Wu EQ, Hill JO. Impact
of cardiometabolic risk factor
clusters on health-related quality
of life in the U.S. Obesity. 2007 Feb;
15(2):511-21. [PMID: 17299125]
Morrato EH, Hill JO, Wyatt HR,
Ghushchyan V, Sullivan PW. Physical
activity in U.S. adults with diabetes
and at risk for developing diabetes,
2003. Diabetes Care. 2007 Feb;30(2):
203-9. [PMID: 17259482]
Sullivan PW, Ghushchyan V,
Wyatt HR, Wu EQ, Hill JO.
Productivity costs associated
with cardiometabolic risk factor
clusters in the United States.
Value Health. 2007 Nov-Dec;10(6):
443-50. [PMID: 17970926]
Phelan S, Wyatt H, Nassery S,
Dibello J, Fava JL, Hill JO, Wing RR.
Three-year weight change in successful weight losers who lost
weight on a low-carbohydrate diet.
Obesity. 2007 Oct;15(10):2470-7.
[PMID: 17925473]
Rodearmel SJ, Wyatt HR,
Stroebele N, Smith SM, Ogden LG,
Hill JO. Small changes in dietary
sugar and physical activity as an
approach to preventing excessive
weight gain: the America on the
Move family study. Pediatrics.
2007 Oct;120(4):e869-79. [PMID:
17908743]
Stroebele N, Wyatt HR, Reed GW,
Peters JC, Hill JO. Step-counter
determined walking in youth in
Colorado. J Phys Act Health. 2007
Jul;4(3):315-24. [PMID: 17846460]
Wagner BD, Grunwald GK,
Rumsfeld JS, Hill JO, Ho PM,
Wyatt HR, Shroyer AL. Relationship
of body mass index with outcomes
after coronary artery bypass graft
surgery. Ann Thorac Surg. 2007
Jul;84(1):10-6. [PMID: 17588373]
Wing RR, Jakicic J, Neiberg R,
Lang W, Blair SN, Cooper L, Hill JO,
Johnson KC, Lewis CE, Look
AHEAD Research Group. Fitness,
fatness, and cardiovascular risk
factors in type 2 diabetes: look
ahead study. Med Sci Sports Exerc.
2007 Dec;39(12):2107-16. [PMID:
18046181]
Wyatt HR. Does insulin concentration modify the outcome of dietary
intervention in young adults with
obesity? Nat Clin Pract Endocrinol
Metab. 2007 Dec;3(12):802-3. [PMID:
17876347]
Maclean PS, Parker AN,
McQuaker IG, Clark AD, Farrell E,
Douglas KW. Ideal body weight
correlates better with engraftment
after PBSC autograft than actual
body weight, but is under-estimated
in myeloma patients possibly due
to disease-related height loss.
Bone Marrow Transplant. 2007
Oct;40(7):665-9. [PMID: 17646841]
Dr. Shikka Sundaram with a patient in the Pediatric Liver Clinic
2 10 D e p a r t m e n t o f P e d i a t r i c s
publications
2006 Publications
DelParigi A, Chen K, Salbe AD,
Hill JO, Wing RR, Reiman EM,
Tataranni PA. Successful dieters
have increased neural activity in
cortical areas involved in the control of behavior. Int J Obes. 2007
Mar;31(3):440-8. [PMID: 16819526]
Dourmashkin JT, Chang GQ, Hill JO,
Gayles EC, Fried SK, Leibowitz SF.
Model for predicting and phenotyping at normal weight the long-term
propensity for obesity in SpragueDawley rats. Physiol Behav. 2006
Apr;87(4):666-78. [PMID: 16513148]
Eckel RH, Hernandez TL, Bell ML,
Weil KM, Shepard TY, Grunwald GK,
Sharp TA, Francis CC, Hill JO. CarboВ­
hydrate balance predicts weight
and fat gain in adults. Am J Clin
Nutr. 2006 Apr;83(4):803-8. [PMID:
16600931]
Hill JO. Understanding and addressing the epidemic of obesity: an
energy balance perspective. Endocr
Rev. 2006 Dec;27(7):750-61. [PMID:
17122359]
Hill JO, Catenacci VA, Wyatt HR.
Obesity:etiology. In: Shils M,
Shike M, Ross AC, Caballero B,
Cousins RJ, editors. Modern
nutrition in health and disease.
10th ed. Philadelphia: Lippincott,
Williams & Wilkins; 2006.
Hill JO, Stuht J, Wyatt HR,
Regensteiner JG. Physical activity
in prevention and management
of obesity and type-2 diabetes.
Nestle Nutr Workshop Ser Clin
Perform Program. 2006;11:183-91.
Review. [PMID: 16820740]
Hill JO, Stuht J, Wyatt HR,
Regensteiner JG. Physical activity
in prevention and management
of obesity and type-2 diabetes.
In: Bantle JP, Slama G, editors.
Nutritional management of diabetes
mellitus and dysmetabolic syndrome. Nestle Nutr Workshop Ser
Clin Perform Program. 2006;11:
183-96.
Jackman MR, Kramer RE,
MacLean PS, Bessesen DH.
Trafficking of dietary fat in obesityprone and obesity-resistant rats.
Am J Physiol Endocrinol Metab.
2006 Nov;291(5):E1083-91 [PMID:
16803858]
Lean M, Lara J, Hill JO. ABC of
obesity. Strategies for preventing obesity. BMJ. 2006 Nov;
333(7575):959-62. Review.
[PMID: 17082548]
Levine JA, Donahoo WT,
Melanson EL. Cellular and wholeanimal energetics. In: Stipanuk MH,
editor. Biochemical, physiological, &
molecular aspects of human nutrition. St. Louis: Saunders/Elsevier;
2006.
Levine JA, Vander Weg MW, Hill JO,
Klesges RC. Non-exercise activity
thermogenesis: the crouching tiger
hidden dragon of societal weight
gain. Arterioscler Thromb Vasc Biol.
2006 Apr;26(4):729-36. Review.
[PMID: 16439708]
Look AHEAD Research Group,
Wadden TA, West DS, Delahanty L,
Jakicic J, Rejeski J, Williamson D,
Berkowitz RI, Kelley DE, Tomchee C,
Hill JO, Kumanyika S. The Look
AHEAD study: a description of the
lifestyle intervention and the evidence supporting it. Obesity. 2006
May;14(5):737-52. Review. [PMID:
16855180]
MacLean PS, Higgins JA,
Jackman MR, Johnson GC,
Fleming-Elder BK, Wyatt HR,
Melanson EL, Hill JO. Peripheral
metabolic responses to prolonged weight reduction that
promote rapid, efficient regain in
obesity-prone rats. Am J Physiol
Regul Integr Comp Physiol. 2006
Jun;290(6):R1577-88. [PMID:
16455763]
Morrato EH, Hill JO, Wyatt HR,
Ghushchyan V, Sullivan PW. Are
health care professionals advising
patients with diabetes or at risk
for developing diabetes to exercise more? Diabetes Care. 2006
Mar;29(3):543-8. [PMID: 16505503]
Phelan S, Wyatt HR, Hill JO, Wing RR.
Are the eating and exercise habits
of successful weight losers changing? Obesity. 2006 Apr;14(4):710-6.
[PMID: 16741274]
Qiao L, MacLean PS, You H,
Schaack J, Shao J. Knocking down
liver ccaat/enhancer-binding
protein alpha by adenovirus-transduced silent interfering ribonucleic
acid improves hepatic gluconeogenesis and lipid homeostasis in
db/db mice. Endocrinology. 2006
Jun;147(6):3060-9. [PMID: 16543372]
Raynor DA, Phelan S, Hill JO,
Wing RR. Television viewing
and long-term weight maintenance: results from the National
Weight Control Registry. Obesity.
2006 Oct;14(10):1816-24. [PMID:
17062812]
Rodearmel SJ, Wyatt HR, Barry MJ,
Dong F, Pan D, Israel RG, Cho SS,
McBurney MI, Hill JO. A familybased approach to preventing
excessive weight gain. Obesity.
2006 Aug;14(8):1392-401. [PMID:
16988082]
Children�s Outcomes
Research Program
2008 Publications
Brayden, RM, Bunik M, Brown J,
Daley M. Ambulatory and community pediatrics. In: Hay WW Jr,
Levin MJ, Sondheimer JM,
Deterding RR, editors. Current
pediatric diagnosis and treatment.
19th ed. New York: McGraw-Hill,
2009.
Bull S, Pratte K, Whitesell N,
Rietmeijer C, McFarlane M. Effects
of an internet-based intervention
for HIV prevention: The Youthnet
Trials. AIDS Behav. 2008 Nov 27.
[PMID: 19037719]
Bull SS, Posner SF, Ortiz C, Beaty B,
Benton K, Lin L, Pals SL, Evans T.
POWER for reproductive health:
results from a social marketing campaign promoting female and male
condoms. J Adolesc Health. 2008
Jul;43(1):71-8. [PMID: 18565440]
Bull SS, Vallejos D, Levine D, Ortiz C.
Improving recruitment and retention for an online randomized conВ­
trolled trial: experience from the
Youthnet study. AIDS Care. 2008
Sep;20(8):887-93. [PMID: 18777217]
Butler RW, Copeland DR,
Fairclough DL, Mulhern RK,
Katz ER, Kazak AE, Noll RB,
Patel SK, Sahler OJ. A multicenter,
randomized clinical trial of a cognitive remediation program for
childhood survivors of a pediatric
malignancy. J Consult Clin Psychol.
2008 Jun;76(3):367-78. [PMID:
18540731]
Crane LA, Daley MF, Barrow J,
Babbel C, Stokley S, Dickinson LM,
Beaty BL, Steiner JF, Kempe A.
Sentinel physician networks as a
technique for rapid immunization
policy surveys. Eval Health Prof.
2008 Mar;31(1):43-64. [PMID:
18184632]
Daley MF, Nyquist A-C, Simoes EAF.
Immunization. In: Hay WW Jr,
Levin MJ, Sondheimer JM,
Deterding RR, editors. Current
pediatric diagnosis and treatment.
19th ed. New York: McGraw Hill;
2009.
Dillon P, Hammermeister K,
Morrato E, Kempe A, Oldham K,
Moss L, Marchildon M, Ziegler M,
Steeger J, Rowell K, Shiloach M,
Henderson W. Developing a NSQIP
module to measure outcomes in
children’s surgical care: opportunity
and challenge. Semin Pediatr Surg.
2008 May;17(2):131-40. [PMID:
18395663]
Fairclough DL, Thijs H, Huang IC,
Finnern HW, Wu AW. Handling missing quality of life data in HIV clinical
trials: what is practical? Qual Life
Res. 2008 Feb;17(1):61-73. [PMID:
18071926]
Gattshall ML, Shoup JA, Marshall JA,
Crane LA, Estabrooks PA. Validation
of a survey instrument to assess
home environments for physical
activity and healthy eating in overВ­
weight children. Int J Behav Nutr
Phys Act. 2008 Jan;5:3. [PMID:
18190709]
Huang IC, Wu AW, Finnern HW,
Thijs H, Gathe JC, Fairclough DL.
Health-related quality of life and tolerability in treatment-experienced
HIV-1-infected patients on tipranavir
versus comparator regimens. Antivir
Ther. 2008;13(1):15-25. [PMID:
18389895]
Hurley LP, Harpaz R, Daley MF,
Crane LA, Beaty BL, Barrow J,
Babbel C, Marin M, Steiner JF,
Davidson A, Dickinson LM, Kempe A.
National survey of primary care physicians regarding herpes zoster and
the herpes zoster vaccine. J Infect
Dis. 2008 Mar;197 Suppl 2:S216-23.
[PMID: 18419400]
2006-2008 Departmental Report
211
publications
Kahl J, Easton J, Johnson G, Zuk J,
Wilson S, Galinkin J. Formocresol
blood levels in children receiving
dental treatment under general
anesthesia. Pediatr Dent. 2008 SepOct;30(5):393-9. [PMID: 18942598]
Kast KR, Berg R, Deas A, Lezotte D,
Crane LA. Colorado dental practiВ­
tioners’ attitudes and practices
regarding tobacco-use prevention
activities for 8- through 12-year-old
patients. J Am Dent Assoc. 2008
Apr;139(4):467-75. [PMID: 18385031]
Kempe A, Hurley L, Stokley S,
Daley MF, Crane LA, Beaty BL,
Dickinson LM, Babbel C, Barrow J,
Steiner JF. Pneumococcal vaccination in general internal medicine
practice: Current practice and
future possibilities. J Gen Intern
Med. 2008 Dec;23(12):2010-3.
[PMID: 18830765]
Morrato EH, Dillon P, Ziegler MM.
Surgical outcomes research: a progression from performance audits,
to assessment of administrative
databases, to prospective riskadjusted analysis – how far have
we come? Curr Opin Pediatr. 2008
Jun;20(3):320-5. Review. [PMID:
18475103]
Morrato EH, Libby AM, Orton HD,
Degruy FV 3rd, Brent DA, Allen R,
Valuck RJ. Frequency of provider
contact after FDA advisory on risk
of pediatric suicidality with SSRIs.
Am J Psychiatry. 2008 Jan;165(1):
42-50. [PMID: 17986680]
Morrato EH, Newcomer JW,
Allen RR, Valuck RJ. Prevalence
of baseline serum glucose and
lipid testing in users of secondgeneration antipsychotic drugs:
A retrospective, population based
study of Medicaid claims data.
J Clin Psychiatry. 2008 Feb;69(2):
316-22. [PMID: 18251625]
Myint-U A, Bull S, Greenwood GL,
Patterson J, Rietmeijer CA, Vrungos S,
Warner L, Moss J, O’Donnell LN.
Safe in the city: developing an effective video-based intervention for
STD clinic waiting rooms. Health
Promot Pract. 2008 Jun 10. [PMID:
18544663]
Padilla R, Bull S, Raghunath SG,
Fernald D, Havranek EP, Steiner JF.
Designing a cardiovascular disease
prevention web site for Latinos:
qualitative community feedback.
Health Promot Pract. 2008 Apr 2.
[PMID: 18385489]
Pyrzanowski JL, Daley MF, Crane LA,
Barrow J, Babbel C, Kempe A.
A qualitative study of physicians’
experiences ordering and receiving
influenza vaccine during the 20052006 influenza season. Prev Med.
2008 Aug;47(2):225-8. [PMID:
18599113]
Simon TD, Emsermann CB,
DiGuiseppi C, Davidson AJ,
Hambidge SJ. Latino families
report lower child injury rates
than white families. Int J Inj Contr
Saf Promot. 2008 Sep;15(3):141-50.
[PMID: 18821378]
Steiner JF, Cavender TA, Nowels CT,
Beaty BL, Bradley CJ, Fairclough DL,
Main DS. The impact of physical and
psychosocial factors on work charВ­
acВ­terВ­istics after cancer. PsychoВ­
oncology. 2008 Feb;17(2): 138-47.
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2007 Publications
Allison MA, Crane LA, Beaty BL,
Davidson AJ, Melinkovich P,
Kempe A. School-based health
centers: improving access and
quality of care for low-income
adolescents. Pediatrics. 2007
Oct;120(4):e887-94. [PMID:
17846146]
Bardenheier BH, Strikas R, Kempe A,
Stokley S, Ellis J. Influenza vaccine
supply, 2005-2006: did we come up
short? BMC Health Serv Res. 2007
May;7:66. [PMID: 17480227]
Berman S. Continuity, the medical
home, and retail-based clinics.
Pediatrics. 2007 Nov;120(5):1123-5.
[PMID: 17974749]
Berman S. State Children’s Health
Insurance Program reauthorization:
will it get us closer to universal
coverage for America’s children?
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Berman S. Universal coverage for
children: alternatives, key issues,
and political opportunities. Health
Aff. 2007 Mar-Apr;26(2):394-404.
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Brown RT, Wiener L, Kupst MJ,
Brennan T, Behrman R, Compas BE,
David Elkin T, Fairclough DL,
Friebert S, Katz E, Kazak AE,
Madan-Swain A, Mansfield N,
Mullins LL, Noll R, Patenaude AF,
Phipps S, Sahler OJ, Sourkes B,
Zeltzer L. Single parents of children
with chronic illness: an understudied phenomenon. J Pediatr Psychol.
2008 May;33(4):408-21. [PMID:
17906331]
Bull S. Internet and other computer
technology-based Interventions for
STD/HIV prevention. In: Edgar T,
Noar SM, Freimuth VS, editors.
Communication perspectives on
HIV/AIDS for the 21st century.
New York: Lawrence Erlbaum
Associates; 2007.
Bull S, Phibbs S, McFarlane M,
Watson S. What do young adults
expect when they go online?
Lessons for development of an
STD/HIV and pregnancy prevention website. J Med Syst. 2007 Apr;
31(2):149-58. [PMID: 17489508]
Bunik M, Glazner JE, Chandramouli V,
Emsermann CB, Hegarty T, Kempe A.
Pediatric telephone call centers:
how do they affect health care use
and costs? Pediatrics. 2007 Feb;
119(2):e305-13. [PMID: 17272593]
Daley MF, Crane LA, Chandramouli V,
Beaty BL, Barrow J, Allred N,
Berman S, Kempe A. Misperceptions
about influenza vaccination among
parents of healthy young children.
Clin Pediatr. 2007 Jun;46(5):408-17.
[PMID: 17556737]
Dolgin MJ, Phipps S, Fairclough DL,
Sahler OJ, Askins M, Noll RB,
Butler RW, Varni JW, Katz ER.
Trajectories of adjustment in
mothers of children with newly
diagnosed cancer: a natural history
investigation. J Pediatr Psychol.
2007 Aug;32(7):771-82. [PMID:
17403910]
Federico S, Tjoeng H, Berman S.
State strategies to reduce the
number of uninsured children.
J Pediatr. 2007 Nov;151(5 Suppl):
S28-31. [PMID: 17950319]
Federico SG, Steiner JF, Beaty B,
Crane L, Kempe A. Disruptions in
insurance coverage: patterns
and relationship to health care
access, unmet need, and utilization
before enrollment in the State
Children’s Health Insurance Program.
Pediatrics. 2007 Oct; 120(4):e100916. [PMID: 17908722]
Hambidge SJ, Emsermann C,
Federico S, Steiner JF. Disparities
in pediatric preventive care in
the United States, 1993-2002.
Arch Pediatr Adolesc Med. 2007
Jan;161(1):30-6. [PMID: 17199064]
Kempe A, Daley MF, Crane LA,
Barrow J, Chandramouli V, Beaty BL,
Allred NJ, Berman S. Misperceptions
regarding influenza vaccine safety
for individuals with chronic medical
illness. Prev Med. 2007 Jul;45(1):
80-2. [PMID: 17234263]
Kempe A, Daley MF, Parashar UD,
Crane LA, Beaty BL, Stokley S,
Barrow J, Babbel C, Dickinson LM,
Widdowson MA, Alexander JP,
Berman S. Will pediatricians
adopt the new rotavirus vaccine?
Pediatrics. 2007 Jan;119(1):1-10.
[PMID: 17200265]
Kempe A, Daley MF, Stokley S,
Crane LA, Beaty BL, Barrow J,
Babbel C, Dickinson LM, Steiner JF,
Berman S. Impact of a severe influenza vaccine shortage on primary
care practice. Am J Prev Med. 2007
Dec;33(6):486-91. [PMID: 18022065]
Libby AM, Brent DA, Morrato EH,
Orton HD, Allen R, Valuck RJ. Decline
in treatment of pediatric depression
after FDA advisory on risk of suicidality with SSRIs. Am J Psychiatry.
2007 Jun;164(6):884-91. [PMID:
17541047]
Morrato EH, Dodd S, Oderda G,
Haxby DG, Allen R, Valuck RJ.
Prevalence, utilization patterns
and predictors of antipsychotic
polypharmacy: experience from a
Multi-State Medicaid Population
(1998-2003). Clin Ther. 2007 Jan;
29(1):183-95. [PMID: 17379060]
publications
Morrato EH, Elias M, Gericke CA.
Using population-based routine
data for evidence-based health
policy decisions: lessons from three
examples of setting and evaluating
national health policy in Australia,
the UK and the USA. J Public Health.
2007 Dec;29(4):463-71. [PMID:
17942850]
Morrato EH, Hill JO, Wyatt HR,
Ghushchyan V, Sullivan PW. Physical
activity in U.S. adults with diabetes
and at risk for developing diabetes,
2003. Diabetes Care. 2007 Feb;
30(2):203-9. [PMID: 17259482]
Morrato EH, Staffa JA. Effectiveness
of risk management plans: a case
study of pemoline using pharmacy
claims data. Pharmacoepidemiol
Drug Saf. 2007 Jan;16(1):104-12.
[PMID: 16821248]
Sills MR, Shetterly S, Xu S, Magid D,
Kempe A. Association between
parental depression and children’s
health care use. Pediatrics. 2007 Apr;
119(4):e829-36. [PMID: 17403826]
Simon TD, Eilert R, Dickinson LM,
Kempe A, Benefield E, Berman S.
Pediatric hospitalist comanagement
of spinal fusion surgery patients.
J Hosp Med. 2007 Jan;2(1):23-30.
[PMID: 17274045]
Szigethy E, Kenney E, Carpenter J,
Hardy DM, Fairclough D,
Bousvaros A, Keljo D, Weisz J,
Beardslee WR, Noll R, Demaso DR.
Cognitive-behavioral therapy for
adolescents with inflammatory
bowel disease and subsyndromal
depression. J Am Acad Child
Adolesc Psychiatry. 2007 Oct;46(10):
1290-8. [PMID: 17885570]
Valuck RJ, Libby AM, Orton HD,
Morrato EH, Allen R, Baldessarini RJ.
Spillover effects on treatment
of adult depression in primary
care after FDA advisory on risk of
pediatric suicidality with SSRIs.
Am J Psychiatry. 2007 Aug;164(8):
1198-05. [PMID: 17671282]
Valuck RJ, Morrato EH, Dodd S,
Oderda G, Haxby DG, Allen R;
Medicaid Pharmacotherapy
Research Consortium. How expensive is antipsychotic polypharmacy?
Experience from five US state
Medicaid programs. Curr Med Res
Opin. 2007 Oct;23(10):2567-76.
[PMID: 17848204]
Weiss SJ, Ernst AA, Sills MR,
Quinn BJ, Johnson A, Nick TG.
Development of a novel measure
of overcrowding in a pediatric
emergency department. Pediatr
Emerg Care. 2007 Sep;23(9):641-5.
[PMID: 17876254]
Ybarra M, Bull SS. Current trends
in Internet- and cell phone-based
HIV prevention and intervention
programs. Curr HIV/AIDS Rep. 2007
Dec;4(4):201-7. [PMID: 18366952]
Hambidge SJ, Glanz JM, France EK,
McClure D, Xu S, Yamasaki K,
Jackson L, Mullooly JP, Zangwill KM,
Marcy SM, Black SB, Lewis EM,
Shinefield HR, Belongia E, Nordin J,
Chen RT, Shay DK, Davis RL,
DeStefano F; Vaccine Safety
Datalink Team. Safety of trivalent
inactivated influenza vaccine in
children 6 to 23 months old. JAMA.
2006 Oct;296(16):1990-7. [PMID:
17062862]
2006 Publications
Allison MA, Daley MF, Crane LA,
Barrow J, Beaty BL, Allred N,
Berman S, Kempe A. Influenza
vaccine effectiveness in healthy
6- to 21-month-old children during
the 2003-2004 season. J Pediatr.
2006 Dec;149(6):755-62. [PMID:
17137887]
Hambidge SJ, Phibbs SL,
Davidson AJ, Lebaron CW,
Chandramouli V, Fairclough DL,
Steiner JF. Individually significant
risk factors do not provide an
accurate clinical prediction rule
for infant underimmunization in
one disadvantaged urban area.
Ambul Pediatr. 2006 May-Jun;
6(3):165-72. [PMID: 16713935]
Bunik M, Clark L, Zimmer LM,
Jimenez LM, O’Connor ME,
Crane LA, Kempe A. Early infant
feeding decisions in low-income
Latinas. Breastfeed Med. 2006
Winter; 1(4):225-35. [PMID:
17661603]
Kempe A, Bunik M, Ellis J, Magid D,
Hegarty T, Dickinson LM, Steiner JF.
How safe is triage by an after-hours
telephone call center? Pediatrics.
2006 Aug;118(2):457-63. [PMID:
16882795]
Bunik M, Gao D, Moore L. An investigation of the field trip model as a
method for teaching breastfeeding
to pediatric residents. J Hum Lact.
2006 May;22(2):195-202. [PMID:
16684908]
Daley MF, Crane LA, Chandramouli V,
Beaty BL, Barrow J, Allred N,
Berman S, Kempe A. Influenza
among healthy young children:
changes in parental attitudes and
predictors of immunization during
the 2003 to 2004 influenza season.
Pediatrics. 2006 Feb;117(2):e268-77.
[PMID: 16452334]
Daley MF, Liddon N, Crane LA,
Beaty BL, Barrow J, Babbel C,
Markowitz LE, Dunne EF, Stokley S,
Dickinson LM, Berman S, Kempe A.
A national survey of pediatrician
knowledge and attitudes regarding
human papillomavirus vaccination.
Pediatrics. 2006 Dec;118(6):2280-9.
[PMID: 17142510]
McCollum M, Ellis SL, Morrato EH,
Sullivan PW. Prevalence of multiple
cardiac risk factors in US adults with
diabetes. Curr Med Res Opin. 2006
Jun;22(6):1031-4. [PMID: 16846537]
Morrato EH, Hill JO, Wyatt HR,
Ghushchyan V, Sullivan PW. Are
health care professionals advising
patients with diabetes or at risk
for developing diabetes to exercise more? Diabetes Care. 2006
Mar;29(3):543-8.[PMID: 16505503]
Simon TD, Phibbs S, Dickinson LM,
Kempe A, Steiner JF, Davidson AJ,
Hambidge SJ. Less anticipatory
guidance is associated with more
subsequent injury visits among
infants. Ambul Pediatr. 2006 NovDec;6(6):318-25. [PMID: 17116604]
Todd J, Armon C, Griggs A, Poole S,
Berman S. Increased rates of morbidity, mortality, and charges for
hospitalized children with public or
no health insurance as compared
with children with private insurance
in Colorado and the United States.
Pediatrics. 2006 Aug;118(2):577-85.
[PMID: 16882810]
Clinical Trials Organization
Publications are listed in each
investigator’s section/program.
Colorado Pediatric
Stroke Program
Publications are listed in Child
Neurology and Hematology,
Oncology and BMT.
Gastrointestinal
Eosinophil Center
Publications are listed in each
investigator’s section/program.
Intellectual and Developmental
Disabilities Research Center
Publications are listed in each
investigator’s section/program.
JFK Partners
2008 Publications
Beall PM, Moody EJ, McIntosh DN,
Hepburn SL, Reed CL. Rapid facial
reactions to emotional facial expressions in typically developing children and children with autism spectrum disorder. J Exp Child Psychol.
2008 Nov:101(3):206-23. [PMID:
18561942]
Gotham K, Risi S, Dawson G,
Tager-Flusberg H, Joseph R,
Carter A, Hepburn S, McMahon W,
Rodier P, Hyman SL, Sigman M,
Rogers S, Landa R, Spence MA,
Osann K, Flodman P, Volkmar F,
Hollander E, Buxbaum J, Pickles A,
Lord C. A replication of the Autism
Diagnostic Observation Schedule
(ADOS) revised algorithms. J Am
Acad Child Adolesc Psychiatry. 2008
Jun;47(6):642-51. [PMID: 18434924]
Hepburn S, Philofsky A, Fidler DJ,
Rogers S. Autism symptoms in
toddlers with Down Syndrome:
a descriptive study. J Appl Res
Intel Dis. 2008;21(1):48-57.
Hepburn SL, DiGuiseppi C,
Rosenberg S, Kaparich K,
Robinson C, Miller L. Use of a
teacher nomination strategy to
screen for autism spectrum
disorders in general education
classrooms: a pilot study.
J Autism Dev Disord. 2008 Feb;
38(2):373-82. [PMID: 17661165]
Linder T, Charlifue-Smith R. Fluency
and voice. In: Linder T, editor. TransВ­
disciplinary play-based intervention.
Baltimore: Paul H. Brookes; 2008.
2006-2008 Departmental Report
213
publications
Linder T, Charlifue-Smith R, Rooke C.
Communication assessment. In:
Linder T, editor. Transdisciplinary
play-based assessment-revised.
Baltimore: Paul H. Brookes; 2008.
Linder T, Charlifue-Smith R, Rooke C.
Communication charts. In: Linder T,
editor. Transdisciplinary play-based
assessment-revised. Baltimore: Paul
H. Brookes; 2008.
Owen-DeSchryver JS, Carr EG,
Cale SI, Blakeley-Smith A.
Promoting social interactions
between students with autism
spectrum disorders and their
peers in inclusive school settings.
Focus Autism Other Dev Disabil.
2008;23:15-28.
Ozonoff S, Young GS, Goldring S,
Greiss-Hess L, Herrera AM, Steele J,
Macari S, Hepburn S, Rogers SJ.
Gross motor development, movement abnormalities, and early
identification of autism. J Autism
Dev Disord. 2008 Apr;38(4):644-56.
[PMID: 17805956]
Reaven JA, Hepburn SL, Ross RG.
Use of the ADOS and ADI-R in children with psychosis: importance of
clinical judgment. Clin Child Psychol
Psychiatry. 2008 Jan;13(1):81-94.
[PMID: 18411867]
Rosenberg SA, Zhang D,
Robinson CC. Prevalence of developmental delays and participation
in early intervention services for
young children. Pediatrics. 2008
Jun;121(6):e1503-9. [PMID:
18504295]
2007 Publications
Betz CL, Cowell JM,
Craft-Rosenberg MJ, Krajicek MJ,
Lobo ML. Health care quality and
outcome guidelines for nursing of
children and families: implications
for pediatric nurse practitioner
practice, research, and policy.
J Pediatr Health Care. 2007 Jan-Feb;
21(1):64-6. [PMID: 17198903]
Dettmer JL, Daunhauer L,
Detmar-Hanna D, Sample PL.
Putting brain injury on the radar:
exploratory reliability and validity
analyses of the screening tool for
identification of acquired brain
injury in school-aged children.
J Head Trauma Rehabil. 2007 NovDec:22(6):339-49. [PMID 18025966]
Fidler DJ, Hepburn SL, Most DE,
Philofsky A, Rogers SJ. Emotional
responsivity in young children with
Williams syndrome. Am J Ment
Retard. 2007 May;112(3):194-206.
[PMID: 17542656]
Fidler DJ, Philofsky A, Hepburn SL.
Language phenotypes and intervention planning: bridging research
and practice. Ment Retard Dev
Disabil Res Rev. 2007;13(1):47-57.
[PMID: 17326117]
Hertzberg D. Rehabilitation nursing
care of people with intellectual/
developmental disabilities.
In: Hoeman S, editor. Rehabilitation
nursing, process and outcomes.
4th ed. St Louis: Elsevier; 2007.
Hertzberg D. Understanding acute
and chronic pain. In: Mauk KL,
editor. The specialty practice of
rehabilitation nursing, a core
curriculum. 5th ed. Glenview, IL:
Association of Rehabilitation
Nurses; 2007.
Reed CL, Beall PM, Stone VE,
Kopelioff L, Pulham DJ, Hepburn SL.
Brief report: perception of body
posture--what individuals with
autism spectrum disorder might be
missing. J Autism Dev Disord. 2007
Sep;37(8):1576-84. [PMID: 17029019]
Newschaffer CJ, Croen LA,
Daniels J, Giarelli E, Grether JK,
Levy SE, Mandell DS, Miller LA,
Pinto-Martin J, Reaven J,
Reynolds AM, Rice CE, Schendel D,
Windham GC. The epidemiology
of autism spectrum disorders.
Annu Rev Public Health. 2007;28:
235-58. Review. [PMID: 17367287]
Rutherford MD, Young GS,
Hepburn S, Rogers SJ. A longitudВ­inal
study of pretend play in autism.
J Autism Dev Disord. 2007 Jul;37(6):
1024-39. [PMID: 17146707]
Philofsky A, Fidler DJ, Hepburn S.
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school-age children with autism
spectrum disorders and Williams
syndrome. Am J Speech Lang
Pathol. 2007 Nov;16(4):368-80.
[PMID: 17971496]
Philofsky A, Hepburn SL. Language
profiles in young children with
fragile X syndrome and autism
symptoms. In: Upner JJ, editor.
New research on fragile X syndrome. New York: Nova Science
Publishers; 2007.
Rapport MJ, Stelzner D, Rodriquez J.
The doctor of physical therapy
degree: a new curriculum for a new
degree. Phys Disabil: Educ Relat
Serv. 2007;26(1):63-76.
Scambler DJ, Hepburn S,
Rutherford MD, Wehner EA,
Rogers SJ. Emotional responsivity in
children with autism, children with
other developmental disabilities,
and children with typical development. J Autism Dev Disord. 2007
Mar;37(3):553-63. [PMID: 16933089]
Scambler DJ, Hepburn SL,
Hagerman RJ, Rogers SJ. A preliminary study of screening for risk of
autism in children with fragile X
syndrome: testing two risk cut-offs
for the checklist for autism in
toddlers. J Intellect Disabil Res.
2007 Apr;51(Pt 4):269-76. [PMID:
17326808]
Yerys BE, Hepburn SL,
Pennington BF, Rogers SJ.
Executive function in preschoolers
with autism: evidence consistent
with a secondary deficit. J Autism
Dev Disord. 2007 Jul;37(6):1068-79.
[PMID: 17171455]
Schmidt GL, Kimel LK,
Winterrowd E, Pennington BF,
Hepburn SL, Rojas DC. Impairments
in phonological processing and
nonverbal intellectual function in
parents of children with autism.
J Clin Exp Neuropsychol. 2008 Jul;
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Schoen SA, Miller LJ, Brett-Green B,
Hepburn SL. Psychophysiology of
children with autism spectrum
disorder. Res Autism Spectr Dis.
2008;2(3):417-29.
Winterrowd E, Hepburn SL, Kimel L,
Reite ML, Rojas DC. Relationship of
psychiatric disorders to measures of
child function in parents of children
with autism. Ment Health Aspects
Dev Disorder. 2008;11(2):42-54.
Playroom in the Outpatient Infusion Center of the Center for Cancer and Blood Disorders
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publications
2006 Publications
Carr EG, Blakeley-Smith A. ClassВ­
room intervention for illness-related
problem behavior in children with
developmental disabilities. Behav
Modif. 2006 Nov;30(6):901-24.
[PMID: 17050770]
Conrad D, Kellar-Guenther Y.
Compassion fatigue, burnout, and
compassion satisfaction among
Colorado child protection workers.
Child Abuse Negl. 2006 Oct;30(10):
1071-80. [PMID: 17014908]
Craft-Rosenberg M, Krajicek M,
editors. Nursing excellence for
children and families. New York:
Springer; 2006.
Fidler DJ, Hepburn S, Rogers S. Early
learning and adaptive behaviour
in toddlers with Down syndrome:
evidence for an emerging behavioural phenotype? Downs Syndr Res
Pract. 2006 Jun;9(3):37-44. [PMID:
16869373]
Fidler DJ, Philofsky AD, Hepburn S.
A case of study of early development in Smith-Magenis Syndrome.
Focus Autism Other Dev Disabil.
2006;21(3):130-7.
Hatten AL, Gatchel RJ, Polatin PB,
Stowell AW. A cost-utility analysis
of chronic spinal pain treatment
outcomes: converting SF-36 data
into quality-adjusted life years.
Clin J Pain. 2006 Oct;22(8):700-11.
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Hatten AL, Gatchel RJ, Polatin PB,
Stowell AW. A cost-utility analysis
of conservative chronic spinal pain
management. J Pain. 2006;7(2):S61.
Hepburn SL, Stone WL. Longitudinal
research on motor imitation in
autism. In: Rogers SJ, Williams JHG,
editors. Imitation and the social
mind. New York: Guilford Press;
2006.
Hepburn SL, Stone WL. Using Carey
temperament scales to assess
behavioral style in children with
autism spectrum disorders. J Autism
Dev Disord. 2006 Jul;36(5):637-42.
[PMID: 16628481]
Holmes CP, Gatchel RJ, Adams LL,
Stowell AW, Hatten A, Noe C, Lou L.
An opioid screening instrument:
long-term evaluation of the utility of
the pain medication questionnaire.
Pain Pract. 2006 Jun;6(2):74-88.
[PMID: 17309714]
Krajicek M, Hamilton B. Physical
safety provisions for care. In:
Craft-Rosenberg M, Krajicek M,
editors. Nursing excellence for
children and families. New York:
Springer; 2006.
Lainhart JE, Bigler ED, Bocian M,
Coon H, Dinh E, Dawson G,
Deutsch CK, Dunn M, Estes A,
Tager-Flusberg H, Folstein S,
Hepburn S, Hyman S, McMahon W,
Minshew N, Munson J, Osann K,
Ozonoff S, Rodier P, Rogers S,
Sigman M, Spence MA, Stodgell CJ,
Volkmar F. Head circumference
and height in autism: a study by the
Collaborative Program of Excellence
in Autism. Am J Med Genet A. 2006
Nov 1;140(21):2257-74.
McElhaney KB, Immele A, Smith FD,
Allen JP. Attachment organization
as a moderator of the link between
friendship quality and adolescent
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2006;8(1):33-46. [PMID: 16581622]
Molloy CA, Morrow AL,
Meinzen-Derr J, Dawson G,
Bernier R, Dunn M, Hyman SL,
McMahon WM, Goudie-Nice J,
Hepburn S, Minshew N, Rogers S,
Sigman M, Spence MA,
Tager-Flusberg H, Volkmar FR,
Lord C. Familial autoimmune
thyroid disease as a risk factor
for regression in children with
Autism Spectrum Disorder: a CPEA
Study. J Autism Dev Disord. 2006
Apr;36(3):317-24. [PMID: 16598435]
Peterson E, Schmidt GL, Tregellas JR,
Winterrowd E, Kopelioff L,
Hepburn S, Reite M, Rojas DC.
A voxel-based morphometry study
of gray matter in parents of children
with autism. Neuroreport. 2006 Aug
21;17(12):1289-92. [PMID: 16951571]
Reaven J, Hepburn S. The parent’s
role in the treatment of anxiety
symptoms in children with highfunctioning autism spectrum disorders. Ment Health Aspects Dev
Disabil. 2006;9(3):73-80.
Richler J, Luyster R, Risi S,
Hsu WL, Dawson G, Bernier R,
Dunn M, Hepburn S, Hyman SL,
McMahon WM, Goudie-Nice J,
Minshew N, Rogers S, Sigman M,
Spence MA, Goldberg WA,
Tager-Flusberg H, Volkmar FR,
Lord C. Is there a �regressive
phenotype’ of Autism Spectrum
Disorder associated with the
measles-mumps-rubella vaccine?
A CPEA Study. J Autism Dev Disord.
2006 Apr;36(3):299-16. [PMID:
16729252]
Rogers SJ, Hayden D, Hepburn S,
Charlifue-Smith R, Hall T, Hayes A.
Teaching young nonverbal children
with autism useful speech: a pilot
study of the Denver model and
PROMPT interventions. J Autism
Dev Disord. 2006 Nov:36(8):1007-24.
[PMID: 16845576]
Scambler DJ, Hepburn SL, Rogers SJ.
A two-year follow-up on risk status
identified by the checklist for autism
in toddlers. J Dev Behav Pediatr.
2006 Apr;27(2 Suppl):S104-10.
[PMID: 16685176]
Valvano J, Rapport MJ. Activityfocused motor interventions for
infants and young children with
neurological conditions. Infants
Young Child. 2006;19(4):292-07.
Medical Education
2008 Publications
Souza K, Kamin C, O’Sullivan P,
Moses A, Heestand D. OrganizaВ­
tional models of educational
technology in U.S. and Canadian
medical schools. Acad Med. 2008
Jul;83(7):69-9. [PMID: 18580092]
2007 Publications
Deterding RR, Wong S, Faries G,
Glover JJ, Garrington TP, Wang M,
Anderson MS, Krugman RD. The
new University of Colorado medical
school curriculum: a pediatric perspective. J Pediatr. 2007 Nov;151
(5 Suppl):S32-6. [PMID: 17950321]
Fallat ME, Glover J. Professionalism
in pediatrics. Pediatrics. 2007 Oct;
120(4):e1123-33. [PMID: 17908731]
Fallat ME, Glover J. Professionalism
in pediatrics: statement of principles. Pediatrics. 2007 Oct;120(4):
895-7. [PMID: 17908776]
Kamin CS. Information technology
in pediatrics. In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric diagnosis
and treatment. 18th ed. New York:
McGraw Hill; 2007.
Kamin C. Effective use of educaВ­
tional technology in medical
education. Colloquium on educational technology: recommendations and guidelines for medical
educators. AAMC Institute for
Improving Medical Education;
Nov 2-7; Washington DC; 2007.
Nelson-Marten P, Glover JJ. Ethical
considerations in oncology nursing.
In: Langhorne ME, Fulton JS,
Otto SE, editors. Oncology nursing.
5th ed. St.Louis: Elsevier; 2007.
Ringel SP, Glover JJ, Yarborough M.
Gifts from industry. In: Reimschisel T,
Williams E, editors. Practical ethics
in clinical neurology. Boston:
Butterword-Heinemann; 2007.
2006 Publications
Glover JJ. Ethical decision-making
guidelines and tools. In: Harman LB,
editor. Ethical challenges in the
management of health information.
2nd ed. Sudbury, MA: Jones and
Bartlett Publishers; 2006.
Pediatric Administration
Siegel R, Gardner S, Merenstein G.
Families in crisis: theoretical
and practical considerations. In:
Merenstein G, Gardner S, editors.
Handbook of neonatal intensive
care. 6th ed. St. Louis: Elsevier; 2006.
Pediatric Heart Lung Center
Publications are listed in each
investigator’s section/program.
Perinatal Research Center
Publications are listed in each
investigator’s section/program.
The Children’s Hospital Clinical
Translational Research Center*
2008 Publications
Jackman MR, Steig A, Higgins JA,
Johnson GC, Fleming-Elder BK,
Bessesen DH, MacLean PS.
Weight regain after sustained
weight reduction is accompanied
by suppressed oxidation of dietary
fat and adipocyte hyperplasia. Am J
Physiol Regul Integr Comp Physiol.
2008 Apr;294(4):R1117-29. [PMID:
18287221]
2006-2008 Departmental Report
215
publications
Oslund KL, Hyde DM, Putney LF,
Alfaro MF, Walby WF, Tyler NK,
Schelegle ES. Activation of neuroВ­
kinin-1 receptors during ozone
inhalation contributes to epithelial
injury and repair. Am J Respir Cell
Mol Biol. 2008 Sep;39(3):279-88.
[PMID: 18390473]
2007 Publications
Alfaro MF, Walby WF, Adams WC,
Schelegle ES. Breath condensate
levels of 8-isoprostane and leukotriene B4 after ozone inhalation are
greater in sensitive versus nonsensitive subjects. Exp Lung Res. 2007
Apr-May;33(3-4):115-33. [PMID:
17558675]
Goldenberg NA, Durham JD,
Knapp-Clevenger R,
Manco-Johnson MJ. A thrombolytic
regimen for high-risk deep venous
thrombosis may substantially
reduce the risk of postthrombotic
syndrome in children. Blood. 2007
Jul 1;110(1):45-53. [PMID: 17360940]
The TODAY Study Group. Treatment
options for type 2 diabetes in adolescents and youth (TODAY): a study
of the comparative efficacy of metformin alone or in combination with
rosiglitazone or lifestyle intervention
in adolescents with type 2 diabetes.
Pediatr Diabetes. 2007;8:74–87.
2006 Publications
Dudden RF, Corcoran K, Kaplan J,
Magouirk J, Rand DC, Smith BT.
The Medical Library Association
Benchmarking Network: development and implementation. J Med
Libr Assoc. 2006 Apr;94(2):107-17.
[PMID: 16636702]
O’Lonergan T, Zodrow JJ. Pediatric
assent: subject protection issues
among adolescent females enrolled
in research. J Law Med Ethics.
2006 Summer;34(2):451-9. [PMID:
16789967]
O’Lonergan TA, Milgrom H.
Outcome measures: linking science
and ethics in clinical research. Curr
Opin Allergy Clin Immunol. 2006
Jun;6(3):139-43. [PMID: 16670502]
Songer T, Glazner J, Coombs L,
Cuttler L, Laffel L, Zhang P, Daniel M,
Estrada S, Klingensmith G, Kriska A,
and the TODAY Study Group.
Examining the economic costs
related to lifestyle and pharmacological interventions in youth
with Type 2 diabetes. Expert Rev.
Pharmacoeconomics Outcomes
Res. 2006;6:315–24.
*Additional publications are listed in
each investigator’s section/program.
The Children’s Hospital
Research Institute
2008 Publications
Bailey HK, Kappy MS, Giller RH,
Gralla J. Time-course and risk factors
of hypothyroidism following allogeneic hematopoietic stem cell
transplantation (HSCT) in children
conditioned with fractionated total
body irradiation. Pediatr Blood
Cancer. 2008 Sep;51(3):405-9.
[PMID: 18523993]
Brown LD, Cavalli C, Harwood JE,
Casadei A, Teng CC, Traggiai C,
Serra G, Bevilacqua G, Battaglia FC.
Plasma concentrations of carbohydrates and sugar alcohols in term
newborns after milk feeding.
Pediatr Res. 2008 Aug;64(2):
189-93. [PMID: 18391836]
Gabriels RL, Agnew JA, Miller LJ,
Gralla J, Pan Z, Goldson E,
Ledbetter JC, Dinkins JP, Hooks E.
Is there a relationship between
restricted, repetitive, stereotyped
behaviors and interests and abnormal sensory response in children
with autism spectrum disorders?
Res Autism Spectr Disord. 2008;2:
660-70.
Porter CC, Liang X, Gralla J,
McGavran L, Albano EA. BCL6
expression correlates with monomorphic histology in children with
posttransplantation lymphoproliferative disease. J Pediatr Hematol
Oncol. 2008 Sep;30(9):684-8.
[PMID: 18776761]
Weiss AS, Gralla J, Chan L, Klem P,
Wiseman AC. Aggressive immunosuppression minimization reduces
graft loss following diagnosis of
BK virus-associated nephropathy: a
comparison of two reduction strategies. Clin J Am Soc Nephrol. 2008
Nov;3(6):1812-9. [PMID: 18650404]
Neu M, Goldstein M, Gao D,
Laudenslager ML. Salivary cortisol
in preterm infants: validation of a
simple method for collecting saliva
for cortisol determination. Early
Hum Dev. 2007 Jan;83(1):47-54.
[PMID: 16766144]
Pacheco TR, Scatena LS,
Hoffenberg EJ, Gralla J, Lee LA.
Cafe au lait macules and juvenile
polyps. Pediatr Dermatol. 2007
Apr 8. [PMID: 17509109]
Soden JS, Devereaux MW, Haas JE,
Gumpricht E, Dahl R, Gralla J,
Traber MG, Sokol RJ. Subcutaneous
vitamin E ameliorates liver injury in
an in vivo model of steatocholesВ­
tasis. Hepatology. 2007 Aug;46(2):
485-95. [PMID: 17659596]
Wathen JE, Gao D, Merritt G,
Georgopoulos G, Battan FK.
A randomized controlled trial
comparing a fascia iliaca compartment nerve block to a traditional
systemic analgesic for femur fractures in a pediatric emergency
department. Ann Emerg Med. 2007
Aug;50(2):162-71, 171.e1. [PMID:
17210208]
2006 Publications
Beroukhim RS, Kruzick TL, Taylor AL,
Gao D, Yetman AT. Progression
of aortic dilation in children with
a functionally normal bicuspid
aortic valve. Am J Cardiol. 2006
Sep;98(6):828-30. [PMID: 16950196]
Dudden RF, Corcoran K, Kaplan J,
Magouirk J, Rand DC, Smith BT.
The Medical Library Association
Benchmarking Network: results.
J Med Libr Assoc. 2006 Apr;94(2):
118-29. [PMID: 16636703]
Bunik M, Gao D, Moore L. An investigation of the field trip model as a
method for teaching breastfeeding
to pediatric residents. J Hum Lact.
2006 May;22(2):195-202. [PMID:
16684908]
Higgins JA, Brown MA, Storlien LH.
Consumption of resistant starch
decreases postprandial lipogenesis
in white adipose tissue of the rat.
Nutr J. 2006;5:25. [PMID: 16987425]
MacLean PS, Higgins JA, Jackman MR,
Johnson GC, Fleming-Elder BK,
Wyatt HR, Melanson EL, Hill JO.
Peripheral metabolic responses to
prolonged weight reduction that
promote rapid, efficient regain in
obesity-prone rats. Am J Physiol
Regul Integr Comp Physiol. 2006
Jun;290(6):R1577-88. [PMID:
16455763]
2007 Publications
Al-Harthi L, MaWhinney S,
Connick E, Schooley RT, (Harwood)
Forster JE, Benson C, Thompson M,
Judson F, Palella F, Landay A.
Immunophenotypic alterations
in acute and early HIV infection.
Clin Immunol. 2007;25:299-308.
[PMID: 17916441]
Condino AA, Sondheimer J, Pan Z,
Gralla J, Perry D, O’Connor JA.
Evaluation of gastroesophageal
reflux in pediatric patients with
asthma using impedance-pH monitoring. J Pediatr. 2006 Aug;149(2):
216-9. [PMID: 16887437]
Dr. Glenn Furuta examines a patient in the Gastrointestinal
Eosinophil Center
2 16 D e p a r t m e n t o f P e d i a t r i c s
publications
Condino AA, Sondheimer J, Pan Z,
Gralla J, Perry D, O’Connor JA.
Evaluation of infantile acid and
nonacid gastroesophageal reflux
using combined pH monitoring
and impedance measurement.
J Pediatr Gastroenterol Nutr. 2006
Jan;42(1):16-21. [PMID: 16385248]
Gao D, Grunwald GK, Rumsfeld JS,
Schooley L, MacKenzie T,
Shroyer AL. Time-varying risk
factors for long-term mortality
after coronary artery bypass graft
surgery. Ann Thorac Surg. 2006
Mar;81(3):793-9. [PMID: 16488675]
LeDuc K, Rosebrook H, Rannie M,
Gao D. Pediatric emergency
department recidivism: demoВ­
graphic characteristics and diaВ­
gnostic predictors. J Emerg Nurs.
2006 Apr; 32(2):131-8. [PMID:
16580475]
Love-Osborne K, Butler N, Gao D,
Zeitler P. Elevated fasting triglycerides predict impaired glucose tolerance in adolescents at risk for type
2 diabetes. Pediatr Diabetes. 2006
Aug;7(4):205-10. [PMID: 16911007]
O’Connor ME, Matthews BS, Gao D.
Effect of open access scheduling
on missed appointments, immuniВ­
zations, and continuity of care for
infant well-child care visits. Arch
Pediatr Adolesc Med. 2006 Sep;
160(9):889-93. [PMID: 16953011]
Polaner DM, Ahuja D, Zuk J, Pan Z.
Video assessment of supraglottic
airway orientation through the
perilaryngeal airway in pediatric
patients. Anesth Analg. 2006 Jun;
102(6):1685-8. [PMID: 16717309]
The Children’s Hospital
Sleep Center
Publications are listed in each
investigator’s section/program.
Colorado WIN Partners
Conrad D, Kellar-Guenther Y.
Compassion fatigue, burnout,
and compassion satisfaction among
Colorado child protection workers.
Child Abuse Negl. 2006;30(10):
1071-80. [PMID: 17014908]
affiliates
Barbara Davis Center for
Childhood Diabetes
2008 Publications
Achenbach P, Barker J, Bonifacio E;
Pre-POINT Study Group. Modulating
the natural history of type 1 diabetes in children at high genetic risk
by mucosal insulin immunization.
Curr Diab Rep. 2008 Apr;8(2):87-93.
Review. [PMID: 18445349]
Aly TA, Baschal EE, Jahromi MM,
Fernando MS, Babu SR, Fingerlin TE,
Kretowski A, Erlich HA, Fain PR,
Rewers MJ, Eisenbarth GS. Analysis
of single nucleotide polymorphisms
identifies major type 1A diabetes
locus telomeric of the major histocompatibility complex. Diabetes.
2008 Mar;57(3):770-6. [PMID:
18065518]
Barker JM, Galea LA. Repeated
estradiol administration alters
different aspects of neurogenesis
and cell death in the hippocampus
of female, but not male, rats. NeuroВ­
science. 2008 Apr;152(4):888-902.
[PMID: 18353559]
Barker JM, Gottlieb PA,
Eisenbarth GS. The immunoВ­
endoВ­crinВ­opathy syndromes.
In: Kronenberg HM, Melmed S,
Polonsky KS, Larsen PR, editors.
Williams textbook of endocrinology.
11th ed. St Louis: Saunders; 2008.
Barker JM, Liu E. Celiac disease:
pathophysiology, clinical manifestations, and associated autoВ­
immune conditions. Adv Pediatr.
2008;55:349-65. Review. [PMID:
19048738]
Barker JM, Triolo TM, Aly TA,
Baschal EE, Babu SR, Kretowski A,
Rewers MJ, Eisenbarth GS. Two
single nucleotide polymorphisms
identify highest-risk diabetes
human leukocyte antigen genotype: potential for rapid screening.
Diabetes. 2008 Nov;57(11):3152-5.
[PMID: 18694972]
Barnes MM, Curran-Everett D,
Hamman RF, Maahs D,
Mayer-Davis EJ, D�Agostino RB Jr,
West N, Dabelea D. Determinants
of adiponectin levels in young
people with Type 1 diabetes.
Diabet Med. 2008 Mar;25(3):365-9.
[PMID: 18307464]
Baschal EE, Eisenbarth GS. Extreme
genetic risk for type 1A diabetes in
the post-genome era. J Autoimmun.
2008 Aug;31(1):1-6. [PMID:
18450419]
Birlea SA, Fain PR, Spritz RA.
A Romanian population isolate
with high frequency of vitiligo
and associated autoimmune diseases. Arch Dermatol. 2008 Mar;
144(3):310-6. [PMID: 18347286]
Bortell R, Pino SC, Greiner DL,
Zipris D, Rossini AA. Closing the
circle between the bedside and
the bench: toll-like receptors in
models of virally induced diabetes.
Ann NY Acad Sci. 2008 Dec;1150:
112-22. [PMID: 19120279]
Chase HP. Un Primer Libro Para
Entender La Diabetes. 11a Ed.
Denver: Children’s Diabetes
Foundation; 2008.
Chase HP, Arslanian S, White NH,
Tamborlane WV. Insulin Glargine
versus intermediate-acting insulin
as the basal component of multiple
daily injection regimens for adolescents with type 1 diabetes mellitus.
J Pediatr. 2008 Oct;153(4):547-53.
[PMID: 18589448]
Diabetes Research in Children
Network (DirecNet) Study Group,
Wilson DM, Kollman C. Relationship
of A1C to glucose concentrations
in children with type 1 diabetes:
assessments by high-frequency
glucose determinations by sensors.
Diabetes Care. 2008 Mar;31(3):
381-5. [PMID: 18056888]
Diabetes Research In Children
Network (DirecNet) Study Group,
Buckingham B, Xing D, Weinzimer S,
Fiallo-Scharer R, Kollman C,
Mauras N, Tsalikian E, Tamborlane W,
Wysocki T, Ruedy K, Beck R. Use of
the DirecNet Applied Treatment
Algorithm (DATA) for diabetes management with a real-time continuous glucose monitor (the FreeStyle
Navigator). Pediatr Diabetes. 2008
Apr;9(2):142-7. [PMID: 18221427]
Diabetes Research in Children
Network (DirecNet) Study Group.
Adiponectin and catecholamine
concentrations during acute exercise in children with type 1 diabetes.
Pediatr Diabetes. 2008 Jun;9(3 Pt
1):221-7. [PMID: 18547236]
Chase HP, Eisenbarth GS. Diabetes
mellitus. In: Hay WW Jr, Levin MJ,
Sondheimer JM, Deterding RR,
editors. Current pediatric diagnosis
and treatment. 19th ed. New York:
McGraw Hill; 2009.
Diabetes Research in Children
Network (DirecNet) Study Group.
Prolonged use of continuous glucose monitors in children with type
1 diabetes on continuous subcutaneous insulin infusion or intensive
multiple-daily injection therapy.
Pediatr Diabetes. 2008 Apr;10(2):
91-6. [PMID: 19175899]
Clarke W, Jones T, Rewers A,
Dunger D, Klingensmith GJ.
Assessment and management
of hypoglycemia in children and
adolescents with diabetes. Pediatr
Diabetes. 2008 Apr;9(2):165-74.
[PMID: 18416698]
Diabetes Research in Children
Network (DirecNet) Study Group.
Adiponectin and catecholamine
concentrations during acute exercise in children with type 1 diabetes.
Pediatr Diabetes. 2008 Jun;9(3 Pt
1):221-7. [PMID: 18547236]
Cobry E, Chase HP, Burdick P,
McFann K, Yetzer H, Scrimgeour L.
Use of CoZmonitor in youth with
type 1 diabetes. Pediatr Diabetes.
2008 Apr;9(2):148-51. [PMID:
18221430]
Diabetes Research in Children
Network (DirecNet) Study Group.
The accuracy of the Guardian RT
continuous glucose monitor in
children with type 1 diabetes.
Diabetes Technol Ther. 2008 Aug;
10(4):266-72. [PMID: 18828242]
Davidson A, Traub-Dargatz JL,
Magnuson R, Hill A, Irwin V,
Newton R, Waller A, Smith K,
Callan RJ, Meehan M, Owen P,
Salman M. Lack of correlation
between antibody titers to
fibrinogen-binding protein of
Streptococcus equi and persistent
carriers of strangles. J Vet Diagn
Invest. 2008 Jul;20(4):457-62.
[PMID: 18599850]
Eisenbarth GS. Do NALP5 antibodies
correlate with hypoparathyroidism
in patients with APS-1? Nat Clin
Pract Endocrinol Metab. 2008
Oct;4(10):544-5. [PMID: 18711407]
Eisenbarth GS, Jeffrey J. The natural
history of type 1A diabetes. Arq
Bras Endocrinol Metabol. 2008
Mar;52(2):146-55. [PMID: 18438525]
2006-2008 Departmental Report
217
publications
Ellis SL, Naik RG, Gemperline K,
Garg SK. Use of continuous glucose
monitoring in patients with type 1
diabetes. Curr Diabetes Rev. 2008
Aug;4(3):207-17. [PMID: 18690902]
Garg S. Concluding words. Diabetes
Obes Metab. 2008 Jul;10 Suppl 2:98.
[PMID: 18577161]
Garg S, Kelly WC, Garg S. Insulin
glargine and glulisine SoloSTAR
pens for the treatment of diabetes.
Expert Rev Med Devices. 2008
Mar;5(2):113-23. [PMID: 18331174]
Garg SK. Insulin glargine: cornerstone treatment for type 2 diabetes
patients. Introduction. Diabetes
Obes Metab. 2008 Jul;10 Suppl 2:
1-4. [PMID: 18577151]
Husain Z, Kelly MA, Eisenbarth GS,
Pugliese A, Awdeh ZL, Larsen CE,
Alper CA. The MHC type 1 diabetes
susceptibility gene is centromeric
to HLA-DQB1. J Autoimmun. 2008
Jun;30(4):266-72. [PMID: 18065200]
Ivy DD, Doran AK, Smith KE,
Mallory GB Jr, Beghetti M, Barst RJ,
Brady D, Law Y, Parker D, Claussen L,
Abman SH. Short- and long-term
effects of inhaled iloprost therapy
in children with pulmonary arterial
hypertension. J Am Coll Cardiol.
2008 Jan;51(2):161-9. [PMID:
18191742]
Garg SK. Role of emerging new
technologies. Diabetes Technol
Ther. 2008 Oct;10(5):413-4. [PMID:
18715219]
JDRF CGM Study Group. JDRF
randomized clinical trial to assess
the efficacy of real-time continuous
glucose monitoring in the management of type 1 diabetes: research
design and methods. Diabetes
Technol Ther. 2008 Aug;10(4):
310-21. [PMID: 18828243]
Garg SK, Banerjee R, Kipnis J.
Neuroprotective immunity:
T cell-derived glutamate endows
astrocytes with a neuroprotective
phenotype. J Immunol. 2008 Mar;
180(6):3866-73. [PMID: 18322194]
Juhl K, Sarkar SA, Wong R, Jensen J,
Hutton JC. The mouse pancreatic
endocrine cell transcriptome
defined in the embryonic Ngn3
null mouse. Diabetes. 2008 Oct;
57(10):2755-61. [PMID: 18599526]
Garg SK, Bookout TR, McFann KK,
Kelly WC, Beatson C, Ellis SL,
Gutin RS, Gottlieb PA. Improved
glycemic control in intensively
treated adult subjects with type
1 diabetes using insulin guidance
software. Diabetes Technol Ther.
2008 Oct;10(5):369-75. [PMID:
18715213]
Juvenile Diabetes Research
FounВ­dation Continuous Glucose
Monitoring Study Group,
Tamborlane WV, Beck RW,
Bode BW, Buckingham B, Chase HP,
Clemons R, Fiallo-Scharer R, Fox LA,
Gilliam LK, Hirsch IB, Huang ES,
Kollman C, Kowalski AJ, Laffel L,
Lawrence JM, Lee J, Mauras N,
O’Grady M, Ruedy KJ, Tansey M,
Tsalikian E, Weinzimer S, Wilson DM,
Wolpert H, Wysocki T, Xing D.
Continuous glucose monitoring and intensive treatment of
type 1 diabetes. N Engl J Med.
2008 Oct;359(14):1464-76. [PMID:
18779236]
Garg SK, Naik RG. Long-acting
insulin analogs versus human insulins. Diabetes Technol Ther. 2008
Oct;10(5):331-2. [PMID: 18715208]
Gerhardt CM, Klingensmith GJ.
New-onset diabetes in an obese
adolescent: diagnostic dilemmas.
Nat Clin Pract Endocrinol Metab.
2008 Oct;4(10):578-83. [PMID:
18725905]
Glasgow RE, Christiansen S,
Smith KS, Stevens VJ, Toobert DJ.
Development and implementation
of an integrated, multi-modality,
user-centered interactive dietary
change program. Health Educ Res.
2008 Aug 18. [PMID: 18711204]
Kawasaki E, Uga M, Nakamura K,
Kuriya G, Satoh T, Fujishima, Ozaki M,
Abiru N, Yamasaki H, Wenzlau JM,
Davidson HW, Hutton JC, Eguchi K.
Association between anti-ZnT8
autoantibody specificities and
SLC30A8 Arg325Trp variant in
Japanese patients with type 1
diabetes. Diabetologia. 2008;51:
2299-302. [PMID: 18850084]
2 18 D e p a r t m e n t o f P e d i a t r i c s
Kobayashi M, Jasinski J, Liu E, Li M,
Miao D, Zhang L, Yu L, Nakayama M,
Eisenbarth GS. Conserved T cell
receptor alpha-chain induces insulin autoantibodies. Proc Natl Acad
Sci USA. 2008 Jul;105(29):10090-4.
[PMID: 18626021]
LaBerge GS, Bennett DC, Fain PR,
Spritz RA. PTPN22 is genetically
associated with risk of generalized
vitiligo, but CTLA4 is not. J Invest
Dermatol. 2008 Jul;128(7):1757-62.
[PMID: 18200060]
Laberge GS, Birlea SA, Fain PR,
Spritz RA. The PTPN22-1858C>T
(R620W) functional polymorphism
is associated with generalized vitiligo in the Romanian population.
Pigment Cell Melanoma Res. 2008
Apr;21(2):206-8. [PMID: 18426414]
Lamb MM, Myers MA, Barriga K,
Zimmet PZ, Rewers M, Norris JM.
Maternal diet during pregnancy
and islet autoimmunity in offspring.
Pediatr Diabetes. 2008 Apr;9(2):
135-41. [PMID: 18221424]
Lamb MM, Yin X, Barriga K,
Hoffman MR, Baron AE,
Eisenbarth GS, Rewers M, Norris JM.
Dietary glycemic index, developВ­
ment of islet autoimmunity, and
subsequent progression to Type 1
diabetes in young children. J Clin
Endocrinol Metab. 2008 Oct;
93(10)3936-42. [PMID: 18682514]
Liu P, Vikis HG, Wang D, Lu Y,
Wang Y, Schwartz AG, Pinney SM,
Yang P, de Andrade M, Petersen GM,
Wiest JS, Fain PR, Gazdar A, Gaba C,
Rothschild H, Mandal D, Coons T,
Lee J, Kupert E, Seminara D, Minna J,
Bailey-Wilson JE, Wu X, Spitz MR,
Eisen T, Houlston RS, Amos CI,
Anderson MW, You M. Familial
aggregation of common sequence
variants on 15q24-25.1 in lung
cancer. J Natl Cancer Inst. 2008 Sep;
100(18):1326-30. [PMID: 18780872]
Liu Y, Wenzlau JM, Yu L, Patel C,
Eisenbarth GS, Hutton JC,
Davidson HW. Conserved
epitopes in the protein tyrosine
phosphatase family of diabetes
autoantigens. Ann NY Acad Sci.
2008 Dec;1150:245-7. [PMID:
19120304]
Maahs DM, Snively BM, Beyer J,
Imperatore G, Bell R, Mayer-Davis EJ,
Dolan LM, Pettitt DJ, Hirsch I,
Rodriguez B, Dabelea D. Weight
and elevated albumin to creatinine
ratio in youth with diabetes: the
SEARCH for Diabetes in Youth Study.
Pediatr Nephrol. 2008 Dec;23(12):
2255-60. [PMID: 18607639]
Maahs DM, Wadwa RP,
Bishop F, Daniels SR, Rewers M,
Klingensmith GJ. Dyslipidemia in
youth with diabetes: to treat or
not to treat? J Pediatr. 2008 Oct;
153(4):458-65. [PMID: 18847618]
Martin-Pagola A, Sisino G, Allende G,
Dominguez-Bendala J, Gianani R,
Reijonen H, Nepom GT, Ricordi C,
Ruiz P, Sageshima J, Ciancio G,
Burke GW, Pugilese A. Diabetologia.
2008 Oct;51(10):1803-13. [PMID:
18696047]
Naik RG, Palmer JP. Latent autoВ­
immune diabetes in adults. In:
Jabbour S, Stephens EA, editors.
Type 1 diabetes in adults: principles
and practice. New York: Informa
Healthcare USA; 2008.
Nair A, Wolter TR, Meyers AJ, Zipris D.
Innate immune pathways in virusinduced autoimmune diaВ­betes. Ann
NY Acad Sci. 2008 Dec; 1150:139-42.
[PMID: 19120282]
Naughton MJ, Ruggiero AM,
Lawrence JM, Imperatore G,
Klingensmith GJ, Waitzfelder B,
McKeown RE, Standiford DA,
Liese AD, Loots B. Health-related
quality of life of children and
adolescents with type 1 or type 2
diabetes mellitus: SEARCH for
Diabetes in Youth Study. Arch
Pediatr Adolesc Med. 2008 Jul;
162(7):649-57. [PMID: 18606936]
Naughton MJ, Ruggiero AM,
Lawrence JM, Imperatore G,
Klingensmith GJ, Waitzfelder B,
McKeown RE, Standiford DA,
Liese AD, Loots B; SEARCH for
Diabetes in Youth Study Group.
Health-related quality of life of
children and adolescents with
type 1 or type 2 diabetes mellitus:
SEARCH for Diabetes in Youth
Study. Arch Pediatr Adolesc Med.
2008 Jul;162(7):649-57. [PMID:
18606936]
publications
Pietropaolo M, Surhigh HM,
Nelson PW, Eisenbarth GS. Primer:
immunity and autoimmunity.
Diabetes. 2008 Nov;57(11):
2872-82. [PMID: 18971434]
Pihoker C, Forsander G, Wolfsdorf J,
Klingensmith GJ. The delivery of
ambulatory diabetes care: structures, processes, and outcomes of
ambulatory diabetes care. Pediatr
Diabetes. 2008 Dec;9(6):609-20.
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Pratte KA, BarГіn AE, Ogden LG,
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Hutton JC, Pugazhenthi S. Dominant
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Temple-Trujillo RE, Klingensmith GJ.
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Vehik K, Hamman RF, Lezotte D,
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Waid DM, Wagner RJ, Putnam A,
Vaitaitis GM, Pennock ND,
Calverley DC, Gottlieb P,
Wagner DH Jr. A unique T cell
subset described as CD4loCD40+
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Wang J, Miao D, Babu S, Yu J,
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not rare at all ages and increases
with older age and obesity. J Clin
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Wang M, Vikis HG, Wang Y, Jia D,
Wang D, Bierut LJ, Bailey-Wilson JE,
Amos CI, Pinney SM, Petersen GM,
de Andrade M, Yang P, Wiest JS,
Fain PR, Schwartz AG, Gazdar A,
Minna J, Gaba C, Rothschild H,
Mandal D, Kupert E, Seminara D,
Liu Y, Viswanathan A, Govindan R,
Anderson MW, You M. Identification
of a novel tumor suppressor gene
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Wang Y, Martin CC, Oeser JK,
Sarkar S, McGuinness OP, Hutton JC,
O’Brien RM. Deletion of the gene
encoding the islet-specific glucose6-phosphatase catalytic subunitrelated protein autoantigen results
in a mild metabolic phenotype.
Diabetologia. 2007 Apr;50(4):774-8.
[PMID: 17265032]
Wenzlau JM, Juhl K, Yu L,
Moua O, Sarkar SA, Gottlieb P,
Rewers M, Eisenbarth GS, Jensen J,
Davidson HW, Hutton JC. The cation
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a major autoantigen in human type
1 diabetes. Proc Natl Acad Sci USA.
2007 Oct;104(43):17040-5. [PMID:
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Young KA, Parrish LA, Zerbe GO,
Rewers M, Deane KD,
Michael Holers V, Norris JM.
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risk factors associated with rheumatoid factor positivity in a healthy
paediatric population. Ann Rheum
Dis. 2007 Feb;66(2):179-83. [PMID:
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Yu L, Wang J, O’Dell JR, Oates J,
Arend WP, Eisenbarth GS. AntidsDNA antibody assay: high specificity and sensitivity with a filtration
radioassay in comparison to low
specificity with the standard ELISA.
J Rheumatol. 2007 Apr;34(4):734-9.
[PMID: 17407230]
Zhang L, Barker JM, Babu S, Su M,
Stenerson M, Cheng M, Shum A,
Zamir E, Badolato R, Law A,
Eisenbarth GS, Anderson MS.
A robust immunoassay for antiinterferon autoantibodies that is
highly specific for patients with
autoimmune polyglandular syndrome type 1. Clin Immunol. 2007
Nov;125(2):131-7. [PMID: 17825626]
Zipris D, Lien E, Nair A, Xie JX,
Greiner DL, Mordes JP, Rossini AA.
TLR9-signaling pathways are
involved in Kilham rat virus-induced
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2006 Publications
Alleva DG, Maki RA, Putnam AL,
Robinson JM, Kipnes MS,
Dandona P, Marks JB, Simmons DL,
Greenbaum CJ, Jimenez RG,
Conlon PJ, Gottlieb PA. ImmunoВ­
modulation in type 1 diabetes by
NBI-6024, an altered peptide ligand
of the insulin B epitope. Scand
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[PMID: 16398702]
Aly TA, Eller E, Ide A, Gowan K,
Babu SR, Erlich HA, Rewers MJ,
Eisenbarth GS, Fain PR. Multi-SNP
analysis of MHC region: remarkable
conservation of HLA-A1-B8-DR3
haplotype. Diabetes. 2006 May;
55(5):1265-9. [PMID: 16644681]
Aly TA, Ide A, Jahromi MM,
Barker JM, Fernando MS, Babu SR,
Yu L, Miao D, Erlich HA, Fain PR,
Barriga KJ, Norris JM, Rewers MJ,
Eisenbarth GS. Extreme genetic risk
for type 1A diabetes. Proc Natl Acad
Sci USA. 2006 Sep;103(38):14074-9.
[PMID: 16966600]
Babaya N, Nakayama M,
Moriyama H, Gianani R, Still T,
Miao D, Yu L, Hutton JC,
Eisenbarth GS. A new model of
insulin-deficient diabetes: male
NOD mice with a single copy of
Ins1 and no Ins2. Diabetologia. 2006
Jun;49(6):1222-8. [PMID: 16612590]
Wilson DM, Beck RW,
Tamborlane WV, Dontchev MJ,
Kollman C, Chase P, Fox LA,
Ruedy KJ, Tsalikian E, Weinzimer SA;
DirecNet Study Group. The accuracy
of the FreeStyle Navigator continuous glucose monitoring system
in children with type 1 diabetes.
Diabetes Care. 2007 Jan;30(1):
59-64. [PMID: 17192334]
Witso E, Palacios G, Ronningen KS,
Cinek O, Janowitz D, Rewers M,
Grinde B, Lipkin WI. Asymptomatic
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Virus Res. 2007 Jan;123(1):19-29.
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Jessica Warmack (left), medical student, with volunteer clinical faculty,
Jay Rabinowitz, MD (right), learning how to examine an adolescent
2 22 D e p a r t m e n t o f P e d i a t r i c s
publications
Barker JM. Clinical review: Type 1
diabetes-associated autoimmunity:
natural history, genetic associations,
and screening. J Clin Endocrinol
Metab. 2006 Apr;91(4):1210-7.
[PMID: 16403820]
Beaudette-Zlatanova BC, Whalen B,
Zipris D, Yagita H, Rozing J, Groen H,
Benjamin CD, Hunig T, Drexhage HA,
Ansari MJ, Leif J, Mordes JP,
Greiner DL, Sayegh MH, Rossini AA.
Costimulation and autoimmune
diabetes in BB rats. Am J Transplant.
2006 May;6(5 Pt 1):894-902. [PMID:
16611325]
Bilbao JR, Calvo B,
Aransay AM, Martin-Pagola A,
Perez de Nanclares G, Aly TA,
Rica I, Vitoria JC, Gaztambide S,
Noble J, Fain PR, Awdeh ZL,
Alper CA, Castano L. Conserved
extended haplotypes discriminate
HLA-DR3-homozygous Basque
patients with type 1 diabetes
mellitus and celiac disease.
Genes Immun. 2006 Oct;7(7):
550-4. [PMID: 16929349]
Chase HP. Nocturnal hypoglycemia
– an unrelenting problem. J Clin
Endocrinol Metab. 2006 Jun;91(6):
2038-9. [PMID: 16757532]
Chase HP. Understanding diabetes.
11th ed. Denver: Children’s Diabetes
Foundation; 2006.
Chase HP, Horner B, McFann K,
Yetzer H, Gaston J, Banion C,
Fiallo-Scharer R, Slover R,
Klingensmith G. The use of insulin
pumps with meal bolus alarms
in children with type 1 diabetes
to improve glycemic control.
Diabetes Care. 2006 May;29(5):
1012-5. [PMID: 16644630]
Dell’Acqua ML, Smith KE, Gorski JA,
Horne EA, Gibson ES, Gomez LL.
Regulation of neuronal PKA
signaling through AKAP targeting dynamics. Eur J Cell Biol. 2006
Jul;85(7):627-33. [PMID: 16504338]
Devendra D, Miao D, Nakayama M,
Eisenbarth GS, Liu E. Pancreatic
autoimmunity induction with insulin B:9-23 peptide and viral mimics
in the NZB mouse. Ann N Y Acad
Sci. 2006 Oct;1079:135-7. [PMID:
17130544]
Dhawan S, Singh B, Garg SK, Hota D,
Dash RJ, Singla AK, Sinha VR. BioВ­
availability of immediate- and
extended-release formulations of
glipizide in healthy male volunteers.
Clin Pharmacokinet. 2006;45(3):
317-24. [PMID: 16509763]
Diabetes Research In Children
Network (Direcnet) Study Group,
Buckingham BA, Kollman C,
Beck R, Kalajian A, Fiallo-Scharer R,
Tansey MJ, Fox LA, Wilson DM,
Weinzimer SA, Ruedy KJ,
Tamborlane WV. Evaluation of
factors affecting CGMS calibration. Diabetes Technol Ther. 2006
Jun;8(3):318-25. [PMID: 16800753]
Diabetes Research in Children
Network (DirecNet) Study Group,
Tsalikian E, Kollman C,
Tamborlane WB, Beck RW,
Fiallo-Scharer R, Fox L, Janz KF,
Ruedy KJ, Wilson D, Xing D,
Weinzimer SA. Prevention of
hypoglycemia during exercise in
children with type 1 diabetes by
suspending basal insulin. Diabetes
Care. 2006 Oct;29(10):2200-4.
[PMID: 17003293]
Diabetes Research in Children
Network (DirecNet) Study Group.
Psychological aspects of continuous
glucose monitoring in pediatric type
1 diabetes. Pediatr Diabetes. 2006
Feb;7(1):32-8. [PMID: 16489972]
Dogra RS, Vaidyanathan P,
Prabakar KR, Marshall KE, Hutton JC,
Pugliese A. Alternative splicing of
G6PC2, the gene coding for the
islet-specific glucose-6-phosphatase
catalytic subunit-related protein
(IGRP), results in differential
exВ­presВ­sion in human thymus and
spleen compared with pancreas.
Diabetologia. 2006 May;49(5):953-7.
[PMID: 16520917]
Edelman S, Garg S, Frias J, Maggs D,
Wang Y, Zhang B, Strobel S, Lutz K,
Kolterman O. A double-blind,
placebo-controlled trial assessing
pramlintide treatment in the setting of intensive insulin therapy
in type 1 diabetes. Diabetes Care.
2006 Oct;29(10):2189-95. [PMID:
17003291]
Elder DA, Prigeon RL, Wadwa RP,
Dolan LM, D’Alessio DA. Beta-cell
function, insulin sensitivity, and
glucose tolerance in obese diabetic
and nondiabetic adolescents and
young adults. J Clin Endocrinol
Metab. 2006 Jan;91(1):185-91.
[PMID 1626380]
Eller E, Vardi P, Babu SR, Bugawan TL,
Erlich HA, Yu L, Fain PR. Celiac
disВ­В­ease and HLA in a Bedouin
kindred. Hum Immunol. 2006 Nov;
67(11):940-50. [PMID: 17145374]
Fain PR, Babu SR, Bennett DC,
Spritz RA. HLA class II haplotype
DRB1*04-DQB1*0301 contributes
to risk of familial generalized vitiligo
and early disease onset. Pigment
Cell Res. 2006 Feb;19(1):51-7.
[PMID: 16420246]
Fiallo-Scharer R, Horner B,
McFann K, Walravens P, Chase HP.
Mixing rapid-acting insulin analogues with insulin glargine in children with type 1 diabetes mellitus.
J Pediatr. 2006 Apr;148(4):481-4.
[PMID: 16647408]
Garg S, Jovanovic L. Relationship
of fasting and hourly blood glucose
levels to HbA1c values: safety, accuracy, and improvements in glucose
profiles obtained using a 7-day continuous glucose sensor. Diabetes
Care. 2006 Dec;29(12):2644-9.
[PMID: 17130198]
Garg S, Rosenstock J, Silverman BL,
Sun B, Konkoy CS, de la Pena A,
Muchmore DB. Efficacy and safety
of preprandial human insulin inhalation powder versus injectable insulin in patients with type 1 diabetes.
Diabetologia. 2006 May;49(5):891-9.
[PMID: 16506054]
Garg S, Zisser H, Schwartz S,
Bailey T, Kaplan R, Ellis S,
Jovanovic L. Improvement in
glycemic excursions with a transcutaneous, real-time continuous
glucose sensor: a randomized
controlled trial. Diabetes Care. 2006
Jan;29(1):44-50. [PMID: 16373894]
Garg SK, Santucci MB, Panitti M,
Pucillo L, Bocchino M, Okajima F,
Bisen PS, Saltini C, Fraziano M.
Does sphingosine 1-phosphate
play a protective role in the course
of pulmonary tuberculosis? Clin
Immunol. 2006 Dec;121(3):260-4.
[PMID: 17049310]
Geng DG, Liu SY, Steck A,
Eisenbarth G, Rewers M, She JX.
Comment on: Biason-Lauber A,
Boehm B, Lang-Muritano M, et al.
(2005) Association of childhood type
1 diabetes mellitus with a variant
of PAX4: possible link to beta cell
regenerative capacity. Diabetologia
48:900-905. Diabetologia. 2006
Jan;49(1):215-6. [PMID: 16362282]
Gianani R, Putnam A, Still T, Yu L,
Miao D, Gill RG, Beilke J, Supon P,
Valentine A, Iveson A, Dunn S,
Eisenbarth GS, Hutton J, Gottlieb P,
Wiseman A. Initial results of screening of nondiabetic organ donors
for expression of islet autoantibodies. J Clin Endocrinol Metab.
2006 May;91(5):1855-61. [PMID:
16478822]
Hagopian WA, Lernmark A,
Rewers MJ, Simell OG, She JX,
Ziegler AG, Krischer JP, Akolkar B.
TEDDY--The environmental determinants of diabetes in the young:
an observational clinical trial. Ann
NY Acad Sci. 2006 Oct;1079:320-6.
[PMID: 17130573]
Hall DA, Wadwa RP, Goldenberg NA,
Norris JM. Maternal risk factors for
term neonatal seizures: population –
based study in Colorado 1989-2003.
J Child Neurol. 2006 Sep;21(99):
795-8. [PMID: 16970888]
Hanas R, Donaghue K,
Klingensmith G, Swift PG. InterВ­
national Society for Pediatric and
Adolescent Diabetes. ISPAD Clinical
Practice Consensus GuideВ­lines
2006-2007. Pediatr Diabetes. 2006
Dec;7(6):341-2. [PMID: 17212602]
Hokanson JE, Kinney GL, Cheng S,
Erlich HA, Kretowski A, Rewers M.
Susceptibility to type 1 diabetes is
associated with ApoCIII gene haplotypes. Diabetes. 2006 Mar;55(3):
834-8. [PMID: 16505251]
Homann D, Dummer W, Wolfe T,
Rodrigo E, Theofilopoulos AN,
Oldstone MB, von Herrath MG.
Lack of intrinsic CTLA-4 expression
has minimal effect on regulation
of antiviral T-cell immunity. J Virol.
2006 Jan;80(1):270-80. [PMID:
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2006-2008 Departmental Report
223
publications
Homann D, Eisenbarth GS.
An immunologic homunculus
for type 1 diabetes. J Clin Invest.
2006 May;116(5):1212-5. [PMID:
16670763]
Jahromi MM, Eisenbarth GS.
Genetic determinants of type 1
diabetes across populations.
Ann N Y Acad Sci. 2006 Oct;1079:
289-99. [PMID: 17130568]
Jasinski JM, Yu L, Nakayama M,
Li MM, Lipes MA, Eisenbarth GS,
Liu E. Transgenic insulin (B:9-23)
T-cell receptor mice develop autoimmune diabetes dependent upon
RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout.
Diabetes. 2006 Jul;55(7):1978-84.
[PMID: 16804066]
Kishiyama CM, Chase HP, Barker JM.
Prevention strategies for type 1
diabetes. Rev Endocr Metab Disord.
2006 Sep;7(3):215-24. [PMID:
17180706]
Kolotkin RL, Zeller M, Modi AC,
Samsa GP, Quinlan NP, Yanovski JA,
Bell SK, Maahs DM, de Serna DG,
Roehrig HR. Assessing weightrelated quality of life in adolescents.
Obesity. 2006 Mar;14(3):448-57.
[PMID: 16648616]
Kretowski A, Hokanson JE,
McFann K, Kinney GL,
Snell-Bergeon JK, Maahs DM,
Wadwa RP, Eckel RH, Ogden LG,
Garg SK, Li J, Cheng S, Erlich HA,
Rewers M. The apolipoprotein
A-IV Gln360His polymorphism
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type 1 diabetes. Diabetologia.
2006 Aug;49(8):1946-54. [PMID:
16770585]
Lawrence JM, Standiford DA,
Loots B, Klingensmith GJ,
Williams DE, Ruggiero A, Liese AD,
Bell RA, Waitzfelder BE,
McKeown RE. Prevalence and
correlates of depressed mood
among youth with diabetes:
the SEARCH for Diabetes in
Youth Study. Pediatrics. 2006
Apr;117(4):1348-58. [PMID:
16585333]
Limesand SW, Rozance PJ,
Zerbe GO, Hutton JC, Hay WW Jr.
Attenuated insulin release and storage in fetal sheep pancreatic islets
with intrauterine growth restriction.
Endocrinology. 2006 Mar;147(3):
1488-97. [PMID: 16339204]
Liu W, Putnam AL, Xu-Yu Z, Szot GL,
Lee MR, Zhu S, Gottlieb PA,
Kapranov P, Gingeras TR,
Fazekas de St Groth B, Clayberger C,
Soper DM, Ziegler SF, Bluestone JA.
CD127 expression inversely correlates with FoxP3 and suppressive
function of human CD4+ T reg cells.
J Exp Med. 2006 Jul;203(7):1701-11.
[PMID: 16818678]
Maahs D, de Serna DG, Kolotkin RL,
Ralston S, Sandate J, Qualls C,
Schade DS. Randomized, doubleblind, placebo-controlled trial of
orlistat for weight loss in adolescents. Endocr Pract. 2006 Jan-Feb;
12(1):18-28. [PMID: 16524859]
Maahs DM, Rewers M. Editorial:
Mortality and renal disease in type 1
diabetes mellitus – progress made,
more to be done. J Clin Endocrinol
Metab. 2006 Oct;91(10):3757-9.
[PMID: 17028289]
Nakayama M, Babaya N, Miao D,
Gianani R, Liu E, Elliott JF,
Eisenbarth GS. Long-term prevention of diabetes and marked suppression of insulin autoantibodies
and insulitis in mice lacking native
insulin B9-23 sequence. Ann N Y
Acad Sci. 2006 Oct;1079:122-9.
[PMID: 17130542]
Ouyang Q, Standifer NE, Quin H,
Gottlieb P, Verchere CB, Nepom GT,
Tan R, Panagiotopoulos C. RecogВ­
nition of HLA class I-restricted betacell epitopes in type 1 diabetes.
Diabetes. 2006 Nov;55(11):3068-74.
[PMID: 17065344]
Poole JA, Barriga K, Leung DY,
Hoffman M, Eisenbarth GS,
Rewers M, Norris JM. Timing of
initial exposure to cereal grains
and the risk of wheat allergy.
Pediatrics. 2006 Jun;117(6):
2175-82. [PMID: 16740862]
Redondo MJ, Babu S, Zeidler A,
Orban T, Yu L, Greenbaum C,
Palmer JP, Cuthbertson D,
Eisenbart

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