Curriculum vitae Mert Erkan, M.D., Associate Professor of Surgery h-Index (as of June 2014): 20 Languages English, German, Turkish Qualifications September 1995 Medical Doctor, University of Istanbul, Istanbul, Turkey March 2001 Qualified Surgeon, University of Istanbul, Istanbul, Turkey: Thesis: İyatrojenik biliyer yaralanma tanısıyla tedavi edilen hastaların retrospektif değerlendirilmesi. December 2007 2nd Doctoral degree, “summa cum laude”, Thesis: The influence of tumor modulated microenvironment on pancreatic cancer behavior. University of Heidelberg, Germany August 2010 Abdominal Surgeon / Speciality in Digestive Surgery, Klinikum r.d. Isar, Technische Universität München / Bayerische Landesärstekammer (Chamber of medicine of Bavaria) December 2011 Associate Professor of Surgery, Chirurgische Klinik, Klinikum r.d.Isar, Technische Universität München, Munich, Germany Professional Appointments 10/1995 – 08/2000 Surgical resident. Department of Surgery, Istanbul Faculty of Medicine, University of Istanbul, Istanbul, Turkey 03/2001 – 04/2002 Consultant Surgeon (Hepato-Pancreato-Biliary Surgery Unit) Department of Surgery, Istabul Faculty of Medicine, University of Istanbul, Istanbul, Turkey 06/2002 – 08/2002 Training in endoscopy. Surgical Endoscopy Unit. Department of Surgery, Istabul Faculty of Medicine, University of Istanbul, Istanbul, Turkey 07/2003 Visiting Surgeon. Department of Surgery, University of Heidelberg, Heidelberg, Germany 10/2003 – 06/2007 Post doctoral research fellow in the European Molecular Biology Laboratory. Department of Surgery, University of Heidelberg, Heidelberg, Germany 07- 10/2007 Post doctoral research fellow. Department of Surgery, Klinikum r.d.Isar, Technische Universität München, Munich, Germany 1 10/2007 – 08/2010 Surgical resident, Department of Surgery, Klinikum r.d.Isar, Technische Universität München, Munich, Germany 08/2010 Qualified Abdominal Surgeon (Medical Board of Bavaria) Department of Surgery, Klinikum r.d.Isar, Technische Universität München, Munich, Germany 01/2011 Consultant Surgeon, Department of Surgery, Klinikum r.d.Isar, Technische Universität München, Munich, Germany 03/2013 – 03/2014 Head of Pancreatic Surgery, Department of Surgery, Klinikum r.d.Isar, Technische Universität München, Munich, Germany 06/2014 - Visiting Associate Prof. of Surgery, Koc University School of Medicine, Istanbul, Turkey Grants 2008 BMBF: NGFNplus. Subproject: Cancer specific activation of stroma. Project number: 01GS08115. Dr. J. Kleeff, Dr. M. Erkan, Dr. C.W. Michalski, Dr. H. Friess. €509.250 2010 DFG: International scientific organisation: Dr. M. Erkan: “Pancreatic star alliance: Consensus criteria on PSC – StellaTUM-“, München 30.01.2011 – 01.02.2011. GZ: ER 563/3-1, AOBJ: 577801. € 11.330 Else-Kröner-Fresenius Stiftung: Molecular mechanisms of cannabinoid- mediated tumor-stroma interactions in pancreatic cancer: Dr. CW Michalski, Dr. M Erkan, Prof. I. Esposito, Prof. J. Kleeff, €300.000 2011 KKF: Kommission für Klinische Forschung TUM: Stellate cells as antigen presenting cells of the pancreas: Characterization of class II MHC and CD83 or CD163 positive sub-populations: Dr. M. Erkan, Dr. D. Stangel, €60.000 EU FP7: Targeting the tumour microenvironment to improve pancreatic cancer prognosis (EPC-TM-Net); EU FP7; 2011-2013; €270.000. Prof. J Kleeff, Dr. M. Erkan, Dr. C.W. Michalski, Prof. I. Esposito, Prof. H. Friess. 2 Memberships International Hepato-Pancreato-Biliary Associaton (IHPBA / E-AHPBA) International Association of Pancreatology (IAP) European Pancreatic Club (EPC) Deutscher Pankreasclub (DPC) Istanbul Chamber of Medicine Turkish Association of Hepato-Pancreato-Biliary Surgery EDS – European Digestive Surgery DGAV – Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie Deutscher Modellflieger Verband e.V. Congress Organisations 5th European Congress of the International Hepato-Pancreato-Biliary Association (IHPBA). 28.-31. Mayi 2003, Istanbul, Turkey 6th Congress of the European Hepato-Pancreato-Biliary Association (EHPBA). 25.-28. May 2005, Heidelberg 31. Deutscher Pankreasclub, 18.-20. November 2010, Munich 1st meeting of the Pancreatic Star Alliance. Consensus Meeting on Pancreatic Stellate Cells. 04. März 2011, Munich- Congress Preisdent Pankreas-Symposium. 16 Mai 2013. Klinikum rechts der Isar, Tecnische Universität München. Munich, Germany. Consensus Workshop on Defining and Standardizing Pancreatic Texture. 30.05.13 – 14:00 – 17:30, Room III. 10th Congress of the E-AHPBA, 29th – 31st May, 2013, Belgrade, Serbia. Belgrade Invited Faculty and Chair 5th European Congress of the IHPBA, 28.-31. Mai 2003, Istanbul, Turkey. Poster-Session: Hepato-Pancreato-Biliary, Chairman 6th Congress of the European Hepato-Pancreato-Biliary Association (EHPBA) 25.-28. Mai 2005, Heidelberg. Session: Hydatid Liver Disease, State of the art lecture: “Laparoscopic cyst- and pericystectomy” 3 31. Deutscher Pankreasclub, 18.-20. November 2010, Munich, State of the art lecture: “Microenvironment of the pancreatic cancer” First meeting of the Pancreatic Star Alliance. Consensus Meeting on Pancreatic Stellate Cells: Does EMT contribute to the population of PSC? First meeting of the Pancreatic Star Alliance. Consensus Meeting on Pancreatic Stellate Cells: Purity and contaminants of PSC isolated by different methods 32. Deutscher Pankreasclub, 17.-19. November 2011, Marburg, Importance of Stroma in inflammation and tumorigenesis. Chairmen: C. Pilarsky, M. Erkan EDS Postgraduate Course – Advances in Gastro-Intetinal Surgery, November 24-26, 2011, Lublin, Poland. Video Session: Surgical options in Klatskin tumors 6th EDS Postgraduate Course – Advances in Gastro-Intetinal Surgery, April 19-21 2012, Thessaloniki, Greece. Incidental carcinoma of the gallbladder: How to deal with it? Viszelmedizin 2012, Gastroenterologie-Viszeralchirurgie 19.-22. September 2012, Hamburg, Germany. AG Pankreas: StellaTUM: Report about the consensus conference Viszelmedizin 2012, Gastroenterologie-Viszeralchirurgie 19.-22. September 2012, Hamburg, Germany. Interactions of pancreatic stellate cells with cancer cells 2012 Joint APA/IAP Annual Meeting, October 31 - November 3, 2012 – Miami, Florida, USA: Mini Symposium: Pancreatic stellate cells and cancer XVI. Annual Meeting of the European Society of Surgery, November 22-24, 2012 Istanbul. Chair: Invited Presentations, 08:00-09:30, 23.11.12 XVI. Annual Meeting of the European Society of Surgery, November 22-24, 2012 Istanbul. Chair: An Ordinary Day in the Theatre, 16:00-17:00, 24.11.12 7th EDS Postgraduate Course – Pitfalls in Gastro-Intestinal Surgery, May 9-11 2013, Istanbul, Turkey. Colorectal cancer management. Case presentations. 10:30-11:30, 11.05.13 10th Congress of the E-AHPBA, 29th – 31st May, 2013, Belgrade, Serbia Breakfast Session: How to do a pancreatic anastomosis? Helmut Friess and Mert Erkan 07:45 – 08:45, 30.05.13 10th Congress of the E-AHPBA, 29th – 31st May, 2013, Belgrade, Serbia: Chair: Session 8: Oral presentations – Pancreas: 30.05.13, 09:00 – 10:00, Amfiteatar, Alain Sauvanet, Mo Hilal, Mert Erkan 10th Congress of the E-AHPBA, 29th – 31st May, 2013, Belgrade, Serbia: Chair: Session 29: Oral presentations – Pancreas: 14:00 – 15:30 , Room IV-1 , Helmut Friess, Mert Erkan, Takashi Hatori 4 10th Congress of the E-AHPBA, 29th – 31st May, 2013, Belgrade, Serbia. Belgrade Consensus Workshop on Defining and Standardizing Pancreatic Texture. 30.05.13 – 14:00 – 17:30, Room III. Onkologisch-chirurgische Viszeralmedizin Kompetenz unter einem Dach. 29.06.2013. Klinkum rechts der Isar, Technische Universität München, Munich, Germany. Grenzwertig resektable Pankreaskarzinome - Grenzen der chirurgischen Therapie Surgical Treatment of Borderline Resectable Pancreatic Cancer, East China Surgery Congress, June 6th-8th, 2014, Hefei, Anhui Province in P.R. of China Reviewer for: (among others) British Journal of Surgery BMC Gastroenterology Carcinogenesis Gastric Cancer (Editorial Board Member) Gastroenterology Gut Journal of Pancreatology Lancet Oncology Molecular Oncology Pancreatology The Journal of Pathology Türkiye Klinikleri Journal of Medical Sciences Trials 5 Publications 1. Erkan M, Kleeff J, Esposito I, Giese T, Ketterer K, Buchler MW, Giese NA, Friess H. Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis. Oncogene. 2005 Jun 23;24(27):4421-32. 2. Erkan M, Tekant Y. Molecular aspects of pancreatic cancer and new threapeutic targets (review in Turkish). Türk HPB 2005;1(2):1-5. 3. Ceyhan GO, Giese NA, Erkan M, Kerscher AG, Wente MN, Giese T, Büchler MW, Friess H. The neurotrophic factor Artemin promotes pancreatic cancer invasion: Ann surg. 2006; 244: 274281. 4. Ceyhan GO, Bergmann F, Kadihasanoglu M, Erkan M, Park W, Gorbachevski A, Buchler MW, Giese N, Friess H. The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis. Gut. 2007; 56:534-44. 5. Erkan M, Kleeff J, Gorbachevski A, Reiser C, Mitkus T, Esposito I, Giese T, Buchler MW, Giese NA, Friess H. Periostin creates a tumor supportive microenvironment in the pancreas by sustaining fibrogenic steallate cell activity. Gastroenterology. 2007; 132:1447-64. 6. Weiwei Zhang, Mert Erkan, Ivane Abiatari, Nathalia A. Giese, Klaus Felix, Hany Kayed, Markus W. Büchler, Helmut Friess, Jörg Kleeff. Expression of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN/CD147) in Pancreatic Neoplasm and Pancreatic Stellate Cells. Cancer Biol Ther. 2007; 6:218-27. 7. Kussumawidjaja G, Kayed H, Bauer A, Giese N, Erkan M, Friess H, Kleeff J. Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells. Cancer Biol Ther. 2007; 6:367-76. 8. Michalski CW*, Oti FE*, Erkan M*, Bergmann F, Pacher P, Batkai S, Müller MW, Giese NA, Friess H, Kleeff J. Cannabinoids in pancreatic cancer: correlation with survival and pain. Int J Cancer. 2008;122(4):742-50. * Equally contributing first author 9. Erkan M, Kleeff J, Reiser C, Hinz U, Esposito I, Friess H, Büchler MW. Pre-operative acute pancreatitis in periampullary tumors: Implications for surgical management. Digestion. 2007 Aug 7; 75:165-171 10. Michalski CW, Kleeff J, Bachmann J, lKhatib J, Erkan M , Esposito I, Friess H, Büchler MW. Second-look operation for unresectable pancreatic ductal adenocarcinoma at a high-volume center. Ann Surg Oncol. 2008; 15(1):186-92. Epub 2007 Oct 18. 11. Michalski CW*, Gorbachevski A*, Erkan M*, Reiser C, Deucker S, Bergmann F, Giese T, Weigand M, Giese NA, Friess H, Kleeff J. Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis. J Transl Med. 2007 Dec 5;5(1):63 * Equally contributing first author 6 12. Hüser N, Michalski CW, Erkan M, Schuster T, Rosenberg R, Kleeff J, Friess H. Systematic review and meta-analysis of the role of defunctioning stoma in low rectal cancer surgery: Is it needed? Ann Surg. 2008 Jul;248(1):52-60. Review. 13. Michalski CW*, Maier M* Erkan M*, Sauliunaite D, Bergmann F, Pacher P, Batkai S, Giese NA, Giese T, Friess H, Kleeff J. Cannabinoids reduce markers of inflammation and fibrosis in pancreatic stellate cells. PLoS ONE. 2008 Feb 27;3(2):e1701. * Equally contributing first author 14. Reiser-Erkan C, Erkan M, Michalski CW, Bekasi S, Giese NA, Giese T, Friess H, Kleeff J. Expression of hypoxia-inducible proto-oncogene Pim-1 in pancreatic neoplasms. Cancer Biol Ther. 2008; 9:1353-1360 15. Erkan M, Michalski CW, Rieder S, Reiser-Erkan C, Abiatari I, Kolb A, Giese NA, Esposito I, Friess H, Kleeff J. Activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma. Clin Gastroenterol Hepatol. 2008 Oct;6(10):1155-61. Epub 2008 Jul 17 16. Michalski CW, Erkan M, Hüser N, Müller MW, Hartel M, Friess H, Kleeff J. Resection of primary pancreatic cancer and liver metastasis: a systematic review. Dig Surg. 2008;25(6):473-80. Epub 2009 Feb 12. 17. Michalski CW*, Erkan M*, Sauliunaite D, Giese T, Stratmann R, Sartori C, Giese NA, Friess H, Kleeff J. Ex vivo chemosensitivity testing and gene expression profiling predict response towards adjuvant gemcitabine treatment in pancreatic cancer. Br J Cancer. 2008 Sep 2;99(5):760-7. * Equally contributing first author 18. Jiang X, Abiatari I, Kong B, Erkan M, De Oliveira T, Giese NA, Michalski CW, Friess H, Kleeff J. Pancreatic Islet and Stellate Cells Are the Main Sources of Endocrine Gland-Derived Vascular Endothelial Growth Factor/Prokineticin-1 in Pancreatic Cancer. Pancreatology. 2008 Dec 13;9(1-2):165-172. 19. Streit S, Michalski CW, Erkan M, Kleeff J, Friess H. Northern blot analysis for detection and quantification of RNA in pancreatic cancer cells and tissues. Nat Protoc. 2009;4(1):37-43. 20. Ceyhan GO, Deucker S, Demir IE, Erkan M, Schmelz M, Bergmann F, Müller MW, Giese T, Büchler MW, Giese NA, Friess H. Neural fractalkine expression is closely linked to pain and pancreatic neuritis in human chronic pancreatitis. Lab Invest. 2009 Mar;89(3):347-61. Epub 2009 Jan 19. 21. Erkan M, Reiser-Erkan C, Michalski CW, Deucker S, Sauliunaite D, Streit S, Esposito I, Friess H, Kleeff J. Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma. Neoplasia. 2009 May;11(5):497-508. 22. Streit S, Michalski CW, Erkan M, Friess H, Kleeff J. Confirmation of DNA Microarray-Derived Differentially Expressed Genes in Pancreatic Cancer Using Quantitative RT-PCR. Pancreatology. 2009 Aug 4;9(5):577-582. 23. Pan Z, Erkan M, Streit S, Friess H, Kleeff J. Silencing of GRP94 expression promotes apoptosis in pancreatic cancer cells. Int J Oncol. 2009 Oct;35(4):823-8. 7 24. Michalski CW, Erkan M, Friess H, Kleeff J. Tumor metabolism to blood flow ratio in pancreatic cancer: helpful in patient stratification. Future Oncol. 2010 Jan;6(1):13-5. 25. Ceyhan GO, Schäfer KH, Kerscher AG, Rauch U, Demir IE, Kadihasanoglu M, Böhm C, Müller MW, Büchler MW, Giese NA, Erkan M, Friess H. Nerve growth factor and artemin are paracrine mediators of pancreatic neuropathy in pancreatic adenocarcinoma. Ann Surg. 2010 May;251(5):923-31. 26. Erkan M, Weis N, Pan Z, Schwager C,Jiang X, Wirkner X, Giese NA, Ansorge W, Debus J, Huber PE, Friess H, Abdollahi A, Kleeff J. Organ-, Inflammation- and Cancer Specific Transcriptional Fingerprints of Pancreatic and Hepatic Stellate Cells. Mol Cancer, 2010 Apr 23;9:88. 27. Holzapfel K, Reiser-Erkan C, Fingerle AA, Erkan M, Eiber MJ, Rummeny EJ, Friess H, Kleeff J, Gaa J. Comparison of diffusion-weighted MR imaging and multidetector-row CT in the detection of liver metastases in patients operated for pancreatic cancer. Abdom Imaging. 2010 Jun 20. 28. Reiser-Erkan C, Erkan M, Ulbrich E, Nahrig J, Kleeff J. Cystic colon duplication causing intussusception in a 25-year-old man: report of a case and review of the literature. BMC Surg. 2010 Jun 23;10(1):19. 29. Kong B, Michalski CW, Hong X, Valkovska N, Rieder S, Abiatari I, Streit S, Erkan M, Esposito I, Friess H, Kleeff J. AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymalto-epithelial transdifferentiation by inhibiting TGFbeta-mediated ERK signaling. Oncogene, 2010 Jun 28. 30. Wang W, Reiser-Erkan C, Raggi MC, Michalski CW, Quan L, Yupei Z, Friess H, Erkan M , Kleeff J. BHLHB2 overexpression is a positive prognostic factor indicating gemcitabine responsiveness in pancreatic cancer. Biochem Biophys Res Commun. 2010 Oct 22;401(3):422-8 31. Samkharadze T*, Erkan M*, Reiser-Erkan C, Demir IE, Bo K, Ceyhan GO, Michalski CW, Esposito I, Friess H, Kleeff J. Pigment Epithelium-Derived Factor Increases Neuropathy and Fibrosis in Pancreatic Cancer. Am J Gastroenterol. 2011 Jan 11 [Epub ahead of print]. * Equally contributing first author 32. Erkan M, Reiser-Erkan C, Michalski CW, Friess H, Kleeff J. Tumor microenvironment and progression of pancreatic cancer. Exp Oncol. 2010 Sep;32(3):128-31 33. Erkan M, Tekant Y. Intraductal Papillary Mucinous Neoplasms of the Pancreas. (Review in Turkish). In press 2011. 34. Paron I, Berchtold S, Vörös J, Shamarla M, Erkan M, Höfler H, Esposito I. Tenascin-C Enhances Pancreatic Cancer Cell Growth and Motility and Affects Cell Adhesion through Activation of the Integrin Pathway. PLoS One. 2011;6(6):e21684. Epub 2011 Jun 29. 35. Kong B, Michalski CW, Erkan M, Friess H, Kleeff J. From tissue turnover to the cell of origin for pancreatic cancer. Nat Rev Gastroenterol Hepatol. 2011 Jul 12. 36. Erkan M, Adler G, Apte MV, Bachem MG, Buchholz M, Detlefsen S, EspositoI, Friess H, Gress T, Habisch HJ, Hwang RF, Jaster R, Kleeff J, Klöppel G, Kordes C, Logsdon CD, Masamune A, Michalski CW, Oh J, Phillips PA, Pinzani M, Reiser-Erkan C, Tsukamoto H, Wilson J. StellaTUM: 8 Current consensus and discussion on pancreatic stellate cell research. Gut. 2012 Feb;61(2):172-8. * All authos have contribute equally 37. Erkan M*, Reiser-Erkan C*, Michalski CW, Kong B, Esposito I, Friess H, Kleeff J. The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance. Curr Mol Med. 2012 Mar 1;12(3):288-303. * Equally contributing first author * * 38. Herrmann K. , Erkan M. , Dobritz M., Schuster T., Siveke J.T., Beer A.J., Wester H.J., Schmid R.M., Friess H., Schwaiger M., Kleeff J., Buck A.K. Comparison of 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography (FLT-PET) and FDG-PET/CT for the detection and characterization of pancreatic tumors. Eur J Nucl Med Mol Imaging. 2012 Jan 26. * Equally contributing first author 39. Regel I, Kong B, Raulefs S, Erkan M, Michalski CW, Hartel M, Kleeff J. Energy metabolism and proliferation in pancreatic carcinogenesis. Langenbecks Arch Surg. 2012 Mar 20. 40. De Oliveira T, Abiatari I, Raulefs S, Sauliunaite D, Erkan M, Kong B, Friess H, Michalski CW, Kleeff J. Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype. Mol Cancer. 2012 Apr 3;11(1):19 41. Mihaljevic AL, Michalski CW, Erkan M, Reiser-Erkan C, Jaeger C, Schuster T, Schuhmacher C, Kleeff J and Friess H. Standard abdominal wound edge protection with surgical dressings vs coverage with a sterile circular polyethylene drape for prevention of surgical site infections (BaFO): study protocol for a randomized controlled trial. Trials 2012, 13:57 42. Erkan M, Hausmann S, Michalski CW, Fingerle AA, Dobritz M, Kleeff J, Friess H. The role of stroma in pancreatic cancer: diagnostic and therapeutic implications. Nat Rev Gastroenterol Hepatol. 2012 Jun 19. 43. Erkan M, Hausmann S, Michalski CW, Schlitter AM, Fingerle AA, Dobritz M, Friess H, Kleeff J. How fibrosis influences imaging and surgical decisions in pancreatic cancer. Front Physiol. 2012;3:389. doi: 10.3389/fphys.2012.00389. Epub 2012 Oct 2. 44. Erkan M. Antifibrotic therapy in pancreatic diseases. Gut. 2012 Dec 22. [Epub ahead of print] 45. Erkan M. Pancreatic stellate cells and cancer. Pancreatology, 2013 Mar-Apr;13(2):106-9. 46. Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, Vandenberg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M. Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. J Clin Invest. 2013 May 1;123(5):2231-43. 47. Erkan M. Understanding the stroma of pancreatic cancer: Coevolution of the microenvironment with the epithelial carcinogenesis. J Pathol. 2013 May 28 48. Stellwag T, Michalski CW, Kong B, Erkan M, Reiser-Erkan C, Jäger C, Meinl C, Friess H, Kleeff J. Comparative analysis of the revenues of pylorus-preserving pancreatic head resections and laparoscopic cholecystectomies as prototypic surgical procedures in the German health care system. Langenbecks Arch Surg, 2013 Aug;398(6):825-31 9 49. Kong Bo, Qia C, Erkan M, Kleeff J, Michalski CW. Overview on how oncogenic Kras promotes pancreatic carcinogenesis by inducing low intracellular ROS levels. Front Physiol. 2013 Sep 12;4:246 50. Balic A, Dræby Sørensen M, Trabulo SM, Sainz B Jr, Cioffi M, Vieira CR, Miranda-Lorenzo I, Hidalgo M, Kleeff J, Erkan M, Heeschen C. Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling. Mol Cancer Ther. 2014 Apr 30. [Epub ahead of print] 51. Hausmann S, Kong B, Michalski C, Erkan M, Friess H. The role of inflammation in pancreatic cancer. Adv Exp Med Biol. 2014;816:129-51 Book Chapters 1. Friess H, Erkan M, Kleeff J, Haberkorn U, Buchler MW. The role of PET in diagnosis of pancreatic cancer and recurrence. The Pancreas: 2008. Eds. H.G. Beger, A.L. Warshaw, R.C.G. Russell, M. Buchler, D. Carr Locke, J.Neoptolemos, M.G. Sarr. 2. Friess H, Kleeff J, Erkan M, Buchler MW. Palliative pancreatico-duodenectoy. The Pancreas: 2008. Eds. H.G. Beger, A.L. Warshaw, R.C.G. Russell, M. Buchler, D. Carr Locke, J.Neoptolemos, M.G. Sarr. 3. Mert Erkan, Helmut Friess, Jörg Kleeff. Apoptosis. In: “Molecular Biology of Cancer”, , 2008. Ed. S. Ossinsky. 4. Erkan M, Esposito I, Friess H, Kleeff J. Tumor-Stromal Interaction: Invasion and Metastasis. Handbook of Pancreatic Cancer: 2009. Eds: J.P. Neoptolemos, R. Urrutia, J.L. Abbruzzese, M.W. Büchler. 5. F. Kolligs, M. Erkan, A. Graser, S. Haraida, T. Helmberger, B. Neu, M. op den Winkel, C. Trumm, C. Tympner, M. Rentsch. Hepatozelluläres Karzinom, Manual: Gastrointestinale Tumoren, Tumorzentrum München. 9. Auflage 2013 6. Mert Erkan, Tania Brocks, Helmut Friess. The Role of Non-cancerous Cells in Cancer: Pancreatic Ductal Adenocarcinoma as a Model to Understand the Impact of Tumor Microenvironment on Epithelial Carcinogenesis. Cancer Targeted Drug Delivery. 2013 Eds: You Han Bae, Randall J. Mrsny, Kinam Park. 7. Simone Hausmann, Bo Kong, Christoph Michalski, Mert Erkan and Helmut Friess. Role of Inflammation in Pancreatic Cancer. Advs Exp. Medicine, Biology, Vol. 816, Inflammation and Cancer. 2014, in press, Eds: Bharat B. Aggarwal et al. 10
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