ΒΙΟΓΡΑΦΙΚΟ ΗΜΔΙΩΜΑ CURRICULUM VITAE ΓΙΩΡΓΟ ΓΙΑΛΛΙΝΑ Καθηγηηής Μοριακής Μικροβιολογίας ΔΘΝΙΚΟ ΚΑΙ ΚΑΠΟΓΙΣΡΙΑΚΟ ΠΑΝΔΠΙΣΗΜΙΟ ΑΘΗΝΩΝ, ΣΜΗΜΑ ΒΙΟΛΟΓΙΑ, ΣΟΜΔΑ ΒΟΣΑΝΙΚΗ επηέμβριος 2014 2 ΠΡΟΩΠΙΚΑ ΣΟΙΥΔΙΑ ΟΝΟΜΑ ΔΠΗΘΔΣΟ ΣΟΠΟ ΓΔΝΝΖΖ ΖΜΔΡΟΜΖΝΗΑ ΓΔΝΝΖΖ ΓΗΔΤΘΤΝΖ ΓΙΩΡΓΟ ΓΙΑΛΛΙΝΑ ΖΡΑΚΛΔΗΟ ΚΡΖΣΖ 21 ΑΤΓΟΤΣΟΤ 1961 ΚΑΑΜΠΑ 37 ΚΑΗΑΡΗΑΝΖ t. 210-7274649, fax. 210-7274702 e-mail: [email protected] Δκπαίδεσζη 1980 - 1981 1981 - 1984 1984 - 1985 1985 - 1989 “A” levels ζηε Βηνινγία, Υεκεία, Μαζεκαηηθά, ρνιή Μσξαΐηε, Αζήλα Bachelor of Science (B.Sc.) ζηελ Κσηηαρική Βιολογία κε Άξηζηα (Honours Class I, University of Essex, Essex, U. K. Diplome d’ Etudes Approfondies (D.E.A.) ζηε Μικροβιολογία, Institut de Microbiologie, Centre d' Orsay, Université de Paris-XI, Orsay, France Thèse de Doctorat (Ph.D) ζηε Μοριακή Βιολογία κε Άξηζηα, Université de Paris XI, Orsay, France Δπαγγελμαηική εμπειρία 1989 – 1990 1991 - 1994 1995 - 1996 1997-1998 1998-2002 20022006-2008 2008-2014 2014- ηξαηησηηθέο ππνρξεψζεηο Μεηαδηδαθηνξηθφο εξεπλεηήο ζην Ηλζηηηνχην Μνξηαθήο Βηνινγίαο θαη Βηνηερλνινγίαο (ΗΜΒΒ), Ζξάθιεην, Κξήηε Μεηαδηδαθηνξηθφο εξεπλεηήο ζην Institut de Génétique et Microbiologie, Centre d’Orsay, Université de Paris-XI, Orsay, France Απηφλνκνο εξεπλεηήο ζην Ηλζηηηνχην Μνξηαθήο Βηνινγίαο θαη Βηνηερλνινγίαο (ΗΜΒΒ), Ζξάθιεην, Κξήηε Λέθηνξαο Μηθξνβηνινγίαο, Παλεπηζηήκην Αζελψλ, Σκήκα Βηνινγίαο Δπίθνπξνο Καζεγεηήο Μνξηαθήο Μηθξνβηνινγίαο, Παλεπηζηήκην Αζελψλ, Σκήκα Βηνινγίαο Μνληκνπνίεζε ζηε Θέζε ηνπ Δπίθνπξνπ Καζεγεηή Μνξηαθήο Μηθξνβηνινγίαο Αλαπιεξσηήο Καζεγεηήο Μνξηαθήο Μηθξνβηνινγίαο Καζεγεηήο Μνξηαθήο Μηθξνβηνινγίαο 3 ΔΚΠΑΙΓΔΤΣΙΚΟ ΔΡΓΟ Γιδαζκαλία & Αζκήζεις μαθημάηφν Πποπηςσιακά μαθήμαηα 1. Γενική Μικποβιολογία 1998-1999 (25% Μάζεκα/65% Αζθήζεηο), 1999-2000 (35% Μάζεκα/65% Αζθήζεηο), 2001-2002 (50% Μάζεκα/65% Αζθήζεηο), 2002-2003 (25% Μάζεκα/65% Αζθήζεηο), 2003-2004 (30% Μάζεκα/40% Αζθήζεηο), 2004-2013 (30% Μάζεκα/40% Αζθήζεηο) 2. Διδικά θέμαηα Μοπιακήρ & Δθαπμοζμένηρ Μικποβιολογίαρ 1999-2000 (35% Μάζεκα/60% Αζθήζεηο), 2000-2002 (50% Μάζεκα/60% Αζθήζεηο), 2003-2013 (50% Μάζεκα/50% Αζθήζεηο) 3. Μικποβιολογία ζην Σκήκα Βηνινγίαο ηνπ Παλεπηζηεκίνπ Κξήηεο (2011-2012) 20 δηδαθηηθέο ψξεο (Αλαπιήξσζε ηνπ ζπλαδέιθνπ Καζ. Α. Οηθνλφκνπ πνπ βξηζθφηαλ ζε άδεηα) Μεηαπηςσιακά μαθήμαηα 1. Αναπηςξιακή Μοπιακή Βιολογία Φςηών 2001-2004, 2006-2012 (Μεηαπηπρηαθφ κάζεκα Σνκέα Βνηαληθήο, 4 σξηαίεο δηαιέμεηο) 2. Μικποβιακή Βιοηεσνολογία 2003-2012 (ΜΓΔ Σνκέα Βνηαληθήο) 8-16 σξηαίεο δηαιέμεηο). πλππεχζπλνο-πλνξγαλσηήο (Μέινο ηεο ηξηκεινχο πληνληζηηθήο Δπηηξνπήο) ηνπ ΜΓΔ Μηθξνβηαθή Βηνηερλνινγία (ζπκκεηνρή ζηελ νξγάλσζε ηεο χιεο, ζηελ πξφζθιεζε δηδαζθφλησλ, ζηνλ πξνυπνινγηζκφ ησλ εμφδσλ θαη αλαγθψλ εμνπιηζκνχ ηνπ εξγαζηεξίνπ, ζηε δηαδηθαζία εμέηαζεο ησλ θνηηεηψλ, επηβιέπσλ δηπισκαηηθψλ εξγαζηψλ) 3. Βιοπληποθοπική (Βηνθπζηθή) 2003-2008 (ΜΓΔ Σνκέα Βηνινγίαο Κπηηάξνπ θαη Βηνθπζηθήο) 9 σξηαίεο δηαιέμεηο 4. Μεηαπηςσιακά ζεμινάπια εκηόρ ΔΚΠΑ ζηην Δλλάδα Μνξηαθή Μηθξνβηνινγία ζην ΑΠΘ, Ηαλνπάξηνο 2002 Μνξηαθή Μηθξνβηνινγία, Ηλζηηηνχην Βηνινγίαο, ΔΚΔΦΔ Γεκφθξηηνο, Ηνχιηνο 2002 Μνξηαθή Μηθξνβηνινγία ζην Παλεπηζηήκην Ησαλλίλσλ, Απξίιηνο 2002, 2004, 2006, 2008, 2011 Μνξηαθή Μηθξνβηνινγία, ΠΜ Δθαξκνγέο ζηηο Βαζηθέο Ηαηξηθέο Δπηζηήκεο, Παλεπηζηήκην Παηξψλ, Ηνχληνο 2013. 5. Μεηαπηςσιακά ζεμινάπια/μαθήμαηα ζε Ιδπύμαηα ηος εξωηεπικού Γηακεκβξαληθνί Μεηαθνξείο, Αdvanced course on “Plasma membrane transporters. Physiology, Genetics & Phylogeny. 2nd Edition”, Universidade do Minho, Centro de Biologia, Departamento de Biologia, Campus de Gualtar, Braga, 04-08/06/2007 “Horizons in Molecular Biology & Genetics”, Bilkent University, Ankara Turkey, Μάηνο 1-2/2008. Γηακεκβξαληθνί Μεηαθνξείο, Αdvanced course on “Plasma membrane transporters. Physiology, Genetics & Phylogeny. 3nd Edition”, Universidade do Minho, Centro de Biologia, Departamento de Biologia, Campus de Gualtar, Braga, Ηνχληνο 2009 Γηακεκβξαληθνί Μεηαθνξείο, Αdvanced course on “Plasma membrane transporters. Physiology, Genetics & Phylogeny. 4ηε Edition”, Universidade do Minho, Centro de Biologia, Departamento de Biologia, Campus de Gualtar, Braga, Ηνχληνο 2012 4 Αdvanced PhD & post-graduate course on Protein Degradation and Trafficking in Health and Disease, 1st edition, Universidade do Minho, Centro de Biologia, Departamento de Biologia, Campus de Gualtar, Braga, Ηνχληνο 2013. Τπεύθσνος σνεργαζιών Δrasmus Universita de Bari, Italia, 2006 Universita de Firenze, Italia, 2006 Universite de Paris VII-Denis Diderot, 2004-2007, Prof. Rosine Haguenauer-Tsapis Universite de Paris-Sud (Paris XI), 2004-2007, Prof. Claudio Scazzocchio J.W. GOETHE-UNIVERSITY, Frankfurt, Germany, 2010-2012, Pd Dr. Roland Kirschner Bonn University, Bonn, Germany, 2010-2013, Prof. C. Muller Universitaet fuer Bodenkultur Wien (BOKU), 2004-2014, Dr. Josef Strauss Universidade do Minho,4710-057 Braga Portugal, 2004-2014 Prof. Margarida Casal σγγραθή ημειώζεφν-Αζκήζεφν ηα πιαίζηα ησλ Μαζεκάησλ Γεληθή Μηθξνβηνινγία θαη Δηδηθά Θέκαηα Μνξηαθήο & Δθαξκνζκέλεο Μηθξνβηνινγίαο ζπλέγξαςα ζεκεηψζεηο (204 θαη 164 ζειίδεο αληίζηνηρα), πνπ δηαηίζεληαη ζε ειεθηξνληθή κνξθή. Δπίζεο ζπλέγξαςα ζεκεηψζεηο 35 ζειίδσλ γηα 5 αζθήζεηο ηνπ καζήκαηνο Δηδηθά Θέκαηα Μνξηαθήο θαη Δθαξκνζκέλεο Μηθξνβηνινγίαο. Μέινο ηεο κεηαθξαζηηθήο νκάδαο πνπ νινθιήξσζε ηε κεηάθξαζε ηνπ Brock Biology of Microorganisms, Madigan, Martinko, Parker eds, απφ ηηο Παλεπηζηεκηαθέο Δθδόζεηο Κξήηεο (Κπθινθνξία Οθηψβξηνο 2005). 5 Δπίβλευη Πηστιακών Δργαζιών πλνιηθά 60 ην δηάζηεκα 2000-2014. 35 απφ απηέο ζην εξγαζηήξην κνπ ζηνλ Σνκέα Βνηαληθήο 1. Παξαζθεπή Πνιπκελάθνπ. Έλα κνηίβν ζπληεξεκέλν ζηνπο κεηαθνξείο λνπθιενβάζεσλΛεηηνπξγηθή αλάιπζε ζηνλ νξγαληζκό Aspergillus nidulans. 1998. πλ-επηβιέπσλ: Καζ. Ν. Παλφπνπινο (Παλ. Κξήηεο) 2. Υξπζνχια Πηηζνχιε. ΚΙΑΑ0238: Πξνο αλαδήηεζε ηεο πιήξνπο δνκήο θαη δηεξεύλεζε ηεο ιεηηνπξγίαο ελόο εκηηεινύο cDNA ηνπ αλζξώπνπ, ην νπνίν εκθαλίδεη in silico ραξαθηεξηζηηθά κεηαθνξέα λνπθιενβάζεσλ. 1998. πλ-επηβιέπσλ: Καζ. Ν. Μνζρνλάο (Παλ. Κξήηεο) 3. ηέθαλνο Γηαηδφγινπ. Απνκόλσζε λέσλ κεηαιιαγώλ ηξνπνπνηεκέλεο εμεηδίθεπζεο ζηνλ κεηαθνξέα νπξηθνύ νμένο ζην κύθεηα Aspergillus nidulans. 2001 4. Νηθφιανο νθφο. Φπζηνινγηθή θαη ιεηηνπξγηθή κειέηε ελόο πηζαλνύ κεηαθνξέα πνπξηλώλ ζηε δύκε Candida albicans. 2001. 5. Δηξήλε Παπαδνπνχινπ. Γελεηηθέο ηξνπνπνηήζεηο ζε αζηξνθπηηαξηθνύο όγθνπο θαη κεληγγηώκαηα. 2001 6. Κίθε νλίια. Αλζεθηηθόηεηα ηνπ θιηληθνύ ζηειέρνπο Τ27 ηνπ εληεξνβαθηεξίνπ Escherichia coli ζηα β-ιαθηακηθά αληηβηνηηθά. 2001 7. Αλαζηαζία Γηψηε: Έθθξαζε θαη κειέηε νκφινγσλ πξσηετλψλ ηεο νηθνγέλεηαο κεηαθνξέσλ λνπθιενηηδηθψλ βάζεσλ ζην κχθεηα Aspergillus nidulans. 2001 8. Γηάλλεο Παπαγεσξγίνπ. Βηνρεκηθόο θαη κνξηαθόο ραξαθηεξηζκόο ηνπ κεηαθνξέα νπξαθίιεο ζην παξαζηηηθό πξσηόδσν Leishmania major. 2002. (πλεπηβιέπoπζα Κ. σηεξηάδνπ, ΔΗΠ). 9. Αξεηή Παληαδνπνχινπ. Γηεξεύλεζε ηνπ ξόινπ ηνπ πξώηνπ δηακεκβξαληθνύ ηκήκαηνο ζηε ζηόρεπζε θαη ιεηηνπξγία ηνπ κεηαθνξέα ηνπ νπξηθνύ νμένο UapA. 2003. 10. νθία Γθνπληέια. Μειέηε ησλ ζπζηεκάησλ πξόζιεςεο λνπθιενηηδηθώλ βάζεσλ ηνπ παζνγόλνπ κύθεηα Candida albicans. 2003. 11. Γήκεηξα Εεξβνχ. Κισλνπνίεζε θαη κειέηε έθθξαζεο γνληδίσλ εμπαλζηλώλ ζηελ πεπνληά. 2003 12. ηέιια Σνπξλαβίηε. Σρέζεηο δνκήο- ιεηηνπξγίαο ζηνλ κεηαθνξέα UapA ηνπ Aspergillus nidulans. 2003. 13. Κσλζηαληίλνο Καγηάο. Μνξηαθόο ραξαθηεξηζκόο λέσλ κεηαιιαγώλ ζηνλ κεηαθνξέα νπξηθνύ νμένο ηνπ κύθεηα Aspergillus nidulans. 2003. 14. Γήκεηξα Μπνπδαξέινπ. Αλίρλεπζε ηκήκαηνο γνληδίνπ ηε (1.2kb) θαη ηνπ κεηαγξάθνπ (170bp) ηνπ θπηηαξνκεγαιντνύ ζε θιηληθά δείγκαηα. 2003. 15. Μαξία Μπηιιίλε. Έθθξαζε θαη κειέηε θπηηθώλ πξντόλησλ ηεο νηθνγέλεηαο κεηαθνξέσλ λνπθιενηηδηθώλ βάζεσλ- αζθνξβηθνύ νμένο ζε πξόηππν κηθξνβηαθό ζύζηεκα. 2003. πλεπηβιέπoπζα Β. νθηαλνπνχινπ, ΔΚΔΦΔ Γεκφθξηηνο. 16. Niki Mangen: Γεκηνπξγία λέσλ ζηειερψλ ηνπ Aspergillus nidulans σο γελεηηθά εξγαιεία γηα ηε κειέηε ησλ κεηαθνξέσλ πνπξηλψλ. 2003 17. Γηάλλεο Βαγγειάηνο. Αλαδεηώληαο γνλίδηα-παξάγνληεο ειέγρνπ ηεο ελδνθπηηαξηθήο ζηόρεπζεο ηνπ κεηαθνξέα πξνιίλεο ζηνλ Aspergillus nidulans. 2004. πλεπηβιέπoπζα Β. νθηαλνπνχινπ, ΔΚΔΦΔ Γεκφθξηηνο. 18. Άλλα Βιαληή: Αλαδεηώληαο γνλίδηα-παξάγνληεο ελδνθπηηαξηθήο ζηόρεπζεο ησλ κεηαθνξέσλ πνπξηλώλ ζηνλ Aspergillus nidulans. 2004. 19. Απνζηφιεο Παπαδνχιεο. Μειέηε γνληδίσλ πνπ απνηεινύλ πηζαλνύο ζηόρνπο ζηνρεπόκελεο θαξκαθνινγηθήο αληηκεηώπηζεο ηνπ παζνγόλνπ πξσηόδσνπ Leishmania: κειέηε ηεο lnp18/h1. 2004. (πλεπηβιέπoπζα Κ. σηεξηάδνπ, ΔΗΠ). 20. Υάξηο Γθηνπιέ. Λεηηνπξγηθφο ραξαθηεξηζκφο ηεο ζξενλίλεο 416 ηνπ κεηαθνξέα νπξηθνχ νμένο-μαλζίλεο UapA ζην κχθεηα Aspergillus nidulans. 2005. 21. Καηεξίλα Ρνπκειηψηε. Φαξαθηεξηζκόο κηαο λέαο νηθνγέλεηαο δηακεκβξαληθώλ κεηαθνξέσλ ππξηκηδηλώλ ζηνλ αζθνκύθεηα Aspergillus nidulans. 2005. 22. Μαξία Παπαθσλζηαληίλνπ. Αλαδήηεζε λέσλ βηνδξαζηηθώλ νπζηώλ θαη θαξκάθσλ κε 6 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. ζηνρεπόκελε δξάζε ζηνπο κεηαθνξείο πνπξηλώλ ηνπ λεκαηνεηδνύο κύθεηα Aspergillus nidulans. 2005. Γεξάζηκνο Λαγγνχζεο. Μειέηε ηεο δπλακηθήο θπηηαξηθήο ηνπνινγίαο ελδύκσλ ηνπ θαηαβνιηζκνύ πνπξηλώλ ζην κύθεηα Aspergillus nidulans. 2006. Διέλε Σζηιηβή. Κηλεηηθή κειέηε ησλ πξσηετληθώλ κεηαθνξέσλ UapC θαη AzgA ζην κύθεηα Aspergillus nidulans. 2006 Θάιεηα Βιάρνπ. Μειέηε ηεο κεηάζεζεο ηνπ transposon impala ηνπ Fusarium oxysporum ζην γνληδίσκα ηνπ Aspergillus nidulans. 2006. Υξήζηνο Γνπξλάο. Λεηηνπξγηθόο ραξαθηεξηζκόο ελόο νκόινγνπ κεηαθνξέα ηεο νηθνγελείαο NAT/NCS2 ηεο Drosophila melanogaster. 2007. Γεσξγία-Μαξία Καξαράιηνπ. Αλάπηπμε γελεηηθώλ θαη κνξηαθώλ εξγαιείσλ γηα ηε κειέηε ηεο ξύζκηζεο ηνπ θαηαβνιηζκνύ ληηξηθώλ ζηνλ Aspergillus nidulans. 2007. Βαζηιηθή Κσζηή. Κηλεηηθή θαη θπζηνινγηθή αλάιπζε κεηαιιαγκέλσλ κνξθώλ ηνπ κεηαθνξέα πνπξηλώλ UapA. 2008. Ησζεθίλα Φσζθφινπ. Μειέηε ησλ JΔΝ1 νκόινγσλ κεηαθνξέσλ θαξβνμπιηθώλ νμέσλ ηνπ κύθεηα Debaromyces hansenii. 2008. Αιέμαλδξνο Πίηηεο. Αλάπηπμε ελόο κηθξνβηαθνύ ζπζηήκαηνο γηα ηε ιεηηνπξγηθή κειέηε κεηαθνξέα αζθνξβηθνύ νμένο ηνπ αλζξώπνπ. πλεπηβιέπoπζα Β. νθηαλνπνχινπ, ΔΚΔΦΔ Γεκφθξηηνο. 2008. Μαξίλα Λάζπα. Αλαδεηώληαο γνλίδηα-παξάγνληεο ηνπνγέλεζεο δηακεκβξαληθώλ κεηαθνξέσλ. 2008. πλεπηβιέπoπζα Β. νθηαλνπνχινπ, ΔΚΔΦΔ Γεκφθξηηνο. 2008. Κάξνινο-Φνίβνο Μπνξκπφιεο. Μειέηε ηεο in vivo έθθξαζεο ηνπ κεηαθνξέα νπξαθίιεο θαη ν ξόινο ηνπ νπξηθνύ νμένο θαη ηεο κεηαθνξάο ηνπ ζηελ αλάπηπμε ηνπ Aspergillus nidulans. 2009. Αλαζηάζηνο Καηνπφδεο. Μειέηε ησλ κεραληζκώλ παζνγέλεηαο ζην παξάζηην Leishmania. πλεπηβιέπoπζα Π. κπξιή, ΔΗΠ. 2008. Αληξέαο Παπιίδεο. Γελεηηθέο κειέηεο ησλ κεραληζκψλ έθθξαζεο ηνπ κεηαθνξέα πνπξηλψλ UapA. 2009 Μαξία Γαιελνχ. Μειέηεο ηεο ηνπνινγίαο ελδύκσλ ηνπ θαηαβνιηζκνύ πνπξηλώλ ζηνλ Aspergillus nidulans. 2010 Michaela Breuer (Erasmus-Austria). Παξαγσγή, θαζαξηζκόο θαη ιεηηνπξγηθή αλαζύζηαζε ζε πξσηενιηπνζώκαηα ηνπ κεηαθνξέα UapA. πλεπηβιέπσλ Γ. Υαηδεληθνιάνπ. 2009-2010. Βαζίιεο Μπίηζηθαο. Υπεξηνληθέο ζπλζήθεο πξνθαιoύλ παξνδηθή πιαζκόιπζε, αλαζηνιή ηεο απμεζεο θαη παξεκπόδηζε ηεο ελδνθύησζεο ζηνλ Aspergillus nidulans θαη ζηνλ Saccharomyces cerevisiae. 2010. Μαξία Κνηίλε. Καηαζθεπή θαη ραξαθηεξηζκόο δηαγνληδηαθώλ παξαζίησλ Leishmania donovani πνπ εθθξάδνπλ ηελ θόθθηλε θζνξίδνπζα πξσηεΐλε mRFP1 θαη αληη-mRFP1 πνιπθισληθνύ αληηζώκαηνο. 2009. πλεπηβιέπoπζα Υ. Μπνιέηε, ΔΗΠ. 2009 Αηκηιία Κξππσηνχ. Γελεηηθέο & Μνξηαθέο πξνζεγγίζεηο ζηελ θαηαλόεζε ησλ ζρέζεσλ δνκήο-ιεηηνπξγίαο ησλ κεηαθνξέσλ λνπθιενηηδηθώλ βάζεσλ NCS1. 2011. Βαζίιεο Γηαιειήο. Γελεηηθέο & Μνξηαθέο κειέηεο ησλ κεραληζκώλ ζηόρεπζεο & ελδνθύησζεο κεηαθνξέσλ ζηνλAspergillus nidulans. 2011 Γεκεηεξεο παλνπδάθεο. Ιζνκνξθέο ηεο ηλβεξηάζεο & μπιαλάζεο ηνπ είδνπο Aspergillus nidulans πνπ θέξνπλ νληνγνληθνύο επηηόπνπο θαη ε ρξήζε ηνπο σο εξγαιεία ζηε κειέηε ηνπ εθθξηηηθνύ κεραληζκνύ ζπλεπηβιέπσληεο. Δπηζηεκνληθνί Τπεχζπλνη: Dr. Migueal Αngel Penalva & Dr. Areti Pantazopoulou, Centro de Investigaciones Biologicas (CIB-CSIC) Madrid, Ηζπαλία (ζηα πιαίζηα ηνπ πξνγξάκκαηνο Erasmus Placement). 2011 Βαζηιηθή Παληαδνπνχινπ. Δηζνζσκηθέο πξσηεΐλεο θαη ηνπνγέλεζε δηακεκβξαληθώλ κεηαθνξέσλ ζηνλ Aspergillus nidulans. πλεπηβιέπoπζα Β. νθηαλνπνχινπ, ΔΚΔΦΔ Γεκφθξηηνο. 2012. Διπηλίθε Νίλνπ. Characterisation of novel elements involved in sugar uptake in Aspergillus nidulans. Δπηζηεκνληθνί Τπεχζπλνη: Margarita Orejas & Dr. Andrew P. MacCabe. Instituto de Agroquímica y Tecnología de Alimentos - IATA, Consejo 7 44. 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. Superior de Investigaciones Científicas-CSIC), Valencia (ζηα πιαίζηα ηνπ πξνγξάκκαηνο Erasmus Placement) 2012. νθία Παλέξε. Characterisation of novel elements involved in sugar uptake in Aspergillus nidulans. Δπηζηεκνληθνί Τπέπζπλνη: Margarita Orejas & Dr. Andrew P. MacCabe. Instituto de Agroquímica y Tecnología de Alimentos - IATA, Consejo Superior de Investigaciones Científicas-CSIC), Valencia (ζηα πιαίζηα ηνπ πξνγξάκκαηνο Erasmus Placement) 2012. Διεπζεξία Κνδνζάθε. Μειέηε θαη ιεηηνπξγηθφο ραξαθηεξηζκφο γνλσηδίσλ ηνπ θπηνπ A. thaliana in plant θαη ζην εηεξφινγν ζχζηεκα ηνπ A. nidulans. πλ-ππεπζπλνο: Κ. Υαξαιακπίδεο. 2012 Αιεμαλδξνο Κφθνηνο. Μειέηε ησλ κεραληζκώλ Καη ηνπ ηππνπ νπβηθνπηηηλησζεο ηνπ κεηαθνξέα UapA- Βηνρεκηθέο πξνζεγγίζεηο. 2012. Καηεξίλα Γαιαλνπνχινπ. Μειέηε ηνπ ππνθπηηαξηθνχ εληνπηζκνχ ελδχκσλ θαηαβνιηζκνχ ησλ πνπξηλψλ ζηνλ Aspergillus nidulans. 2013 Μτλσαο Δπαγγειηλφο. Μειέηε ησλ κεραληζκώλ ελδνθύησζεο ηνπ κεηαθνξέα UapAΓελεηηθέο & Μνξηαθέο πξνζεγγίζεηο. 2013 Διέλε Φσηεηλνχ. Αλαδεηψληαο ηνλ ξφιν ηεο flotillin ζηνλ Aspergillus nidulans. 2013 Γηάλλεο ηαζηλφπνπινο. Αλαδεηψληαο γνλίδηα ηεο νκνηφζηαζεο ηεο έθθξηζεο ζηνλ Aspergillus nidulans. 2013. Ζιηάλα Εψε. Ο ξόινο ηεο ρξσκαηίλεο ζηε δηαδηθαζία γελεηηθήο κεηάζεζεο ηνπ ηξαλζπνδνλίνπ Minos ζηνλ Aspergillus nidulans. 2012-13. Κιεηψ Καηζνπξίδε. Μειέηε ηεο ξύζκηζεο ηνπ θαηαβνιηζκνύ ξακλόδεο ζηνλ Aspergillus nidulans. Δπηζηεκνληθνί Τπεχζπλνη: Margarita Orejas & Dr. Andrew P. MacCabe. Instituto de Agroquímica y Tecnología de Alimentos - IATA, Consejo Superior de Investigaciones Científicas - CSIC), Valencia (ζηα πιαίζηα ηνπ πξνγξάκκαηνο Erasmus Placement) 2012-13. Κσλζηαληίλα Μίηζε. Φαξαθηεξηζκόο ηνπ κεηαγξαθηθνύ ελεξγνπνηεηή ηνπ γνληδίνπ ηεο ξακλνζηδάζεο. Δπηζηεκνληθνί Τπεχζπλνη: Margarita Orejas & Dr. Andrew P. MacCabe. Instituto de Agroquímica y Tecnología de Alimentos - IATA, Consejo Superior de Investigaciones Científicas - CSIC), Valencia (ζηα πιαίζηα ηνπ πξνγξάκκαηνο Erasmus Placement) 2012-13 Ναηάιηα Μηραήινβηηο. Μεκβξαληθή δηαθίλεζε ηνπ κεηαθνξέα GAP1 θαη ζεκαηνδόηεζε ηεο δηαζεζηκόηεηαο ακηλνμέσλ ζηνλ Saccharomyces cerevisiae. Δ.Τ: Dr. Bruno Andrè Lab Physiologie Moléculaire de la Cellule ULB - Institut de Biologie et de Médecine Moléculaires, 6041 Gosselies, Βέιγην (ζηα πιαίζηα ηνπ πξνγξάκκαηνο Erasmus Placement) 2012-13. Δηξήλε Ρνπζνπλέινπ. Μεραληζκνί κεβξαληθήο θπθινθνξίαο θαη απνδφκηζεο πξσηετλσλ ζην πξφηππν ζχζηεκα ηνπ Aspergillus nidulans. 2013-14. Γεξάζηκνο Αλαγλσζηφπνπινο. Έιεγρνο ηεο απφδνζεο, ζπρλφηεηαο θαη ηπραηφηεηαο γελεηηθήο κεηάζεζεο ηνπ ηξαλζπνδνλίνπ Minos ζηνλ Aspergillus nidulans. 2013-14. Ηάθσβνο Μπνκπφλεο. Λεηηνπξγηθφο ραξαθηεξηζκφο, γελεηηθή ηξνπνπνίεζε θαη κνξηαθή εμέιημε κεηαθνξέσλ πνπξηλψλ ησλ νηθνγελεηψλ ΝΑΣ & NCS1 Ζιηάλα Καξβέια Κνινγεξάθε. Ο ξφινο ηεο ρξσκαηίλεο θαη ηεο γσληδηαθήο απνζηψπεζεο ζηε δηαδηθαζία γελεηηθήο κεηάζεζεο ηνπ ηξαλζπνδνλίνπ Minos ζηνλ Aspergillus nidulans. πλεξγαζία κε ην εξγαζηήξην ηεο Γξ. Β. νθηαλνπνχινπ (Δξεπλήηξηα Α) ζην Ηλζηηηνχην Βηνινγίαο ηνπ ΔΚΔΦΔ Γεκφθξηηνο. 2013-14. Βαζηιηθή Αιεμαλδξή. Βειηζηνπνίεζε ζπζηήκαηνο γνληδηαθήο παγίδεπζεο θαη αλάπηπμε κεζνδνινγηψλ δηαινγήο γνληδίσλ πνπ εκπιέθνληαη ζηελ καζεζε ζηελ D. melanogaster. πλεξγαζία κε ην εξγαζηήξην ηνπ Γξ. Δ. θνπιάθε (Δξεπλεηήο Α, Ηλζηηηνχην Κπηαξξηθήο & Αλαπηπμηαθήο βηνινγίαο) ζην ζην Δξεπλεηηθφ Κέληξν Βηνταηξηθψλ Δπηζηεκψλ "Αιέμαλδξνο Φιέκηλγθ ζηε Βάξε. 2013-14. Δπακεηλψλδαο Εαθεηξάηνο. Ο ξφινο ηεο θηλάζεο GCN-2 ζηελ απφθξηζε ζην ζηξεο θαη δηάξθεηα δσήο ηνπ λεκαηψδε C. elegans. πλεξγαζία κε ην εξγαζηήξην ηεο Γξ. Κ. πληηράθε (Δξεπλεηήηξηα Β) ζην Ίδξπκα Ηαηξνβηνινγηθψλ Δξεπλψλ ηεο Αθαδεκίαο Αζελψλ (ΗΗΒΔΑΑ). 2013-14. 8 61. Γεσξγία ηνχπνιε. Μνξηαθή εμέιημε ηεο εμεηδίθεπζεο κεηαθνξέσλ πνπξηλψλ. 201415. 62. Ησάλλα Μπξσλίδε. Μεηαζρεκαηηζκφο θαη γελεηηθφο ρεηξηζκφο ελφο λένπ αζθνκχθεηα (Paecilomyces variotii) θαηάιιεινπ γηα ηελ παξαγσγή βηνθαπζίκσλ δεχηεξεο γεληάο. 2014-15 (πλε-επηβιεςε κε Δπηθ. Καζ. Γ. Υαηδεληθνιάνπ). 2014-15. 63. Μηιέλα Νηνπκπφβηλα. Μεκβξαληθή δηαθίλεζε θαη ζεκαηνδφηεζε ησλ κεηαθνξέσλ ακηλνμέσλ ζηνλ Saccharomyces cerevisiae (Traffic and signaling of yeast amino acid transporters)-Erasmus placement-Γξ.Bruno Andre, ULB, Gosselies, Belgium. 2014-15 64. Κνράξ Υνξνδηάλ.Κπηηαξηθή δηαθίλεζε θαη απνδφκεζε δηακεκβξαληθψλ πξσηετλψλ ζε απφθξηζε ζε γελεηηθά, θπζηνινγηθά θαη ζηξεζνγφλα ζήκαηα. 2014-15. Δπίβλευη Γιπλφμαηικών Δργαζιών ηοσ Μ.Γ.Δ. Μικποβιακή Βιοηεσνολογία 1. Κσλζηαληίλνο Καγηάο: Chromatin structure and regulation of uapA gene of Aspergillus nidulans, 2005. 2. Άλλα Μπφκπνξε: ρέζεηο δνκήο-ιεηηνπξγίαο ζην κεηαθνξέα πξνιίλεο PrnΒ ηνπ Αspergillus nidulans: ν ξφινο ζπγθεθξηκέλσλ ακηλνμέσλ ζηελ πξψηε δηακεκβξαληθή πεξηνρή, 2007. 3. Αλαζηαζία Παπινπνχινπ: Isolation and characterization of the gene mutant-31 required for epigenetic transcriptional silencing and DNA damage repair in Chlamydomonas reinhardtii, 2006. 4. Esra Karakose: Functional characterization of LOC115098: A novel gene conserved in eukaryotic genomes, 2007. 5. Βαζίιεο Νηάλνο: Πξσηετληθέο αιιειεπηδξάζεηο γηα νιφθιεξα κηθξνβηαθά γνληδηψκαηα κε βάζε ηελ αλάιπζε ζπγρψλεπζεο πξσηετληθψλ δνκηθψλ ελνηήησλ (IBEAA). 2009. 6. Αξζέληνο Βιάζζεο: H πείλα γηα ακηλνμέα επάγεη κεηαγξαθηθέο αιιαγέο ζε δηάθνξνπο θπηηαξηθνχο ηχπνπο ηνπ λεκαηψδνπο Caenorhabditis elegans (IΗBEA) 2010 7. Μαξίλα Παληαδνπνχινπ: Role of ubiquitylation in protein sorting into the MVBs in yeast (Institut Jacques Monod, Paris VII). 2010 8. Γέζπνηλα Καπαζά: Μειέηε πξσηετληθψλ αιιειεπηδξάζεσλ κηθξννξγαληζκψλ πνπ πξνέξρνληαη απφ γνληδηαθή ζπγρψλεπζε (IBEAA). 2010 9. Βαζηιηθή Κσζηή: Γηεξέπλεζε λέσλ πεξηνρψλ ηνπ κεηαθνξέα UapA πνπ ζπκκεηέρνπλ ζηελ εθιεθηηθή πξφζιεςε ππνζηξσκάησλ. 2010 10. Γεσξγία-Μαξία Καξαράιηνπ: Heterologous expression & functional characterization of nucleobase transporters in Saccharomyces cerevisiae. 2012 Δπίζεο κέινο ηξηκειψλ ζπκβνπιεπηηθψλ επηηξφπσλ > 50 δηπισκαηηθψλ εξγαζηψλ ηνπ Μ.Γ.Δ. (MSc) Μηθξνβηαθή Βηνηερλνινγία (Σκήκα Βηνινγίαο, ΔΚΠΑ) (2004-2014). 9 Μέλος Σριμελών σμβοσλεσηικών Δπιηροπών Γιδακηορικών Γιαηριβών χλνιν: 37 (25 ζηνλ Σνκέα Βνηαληθήο), ζε 22 Δπηβιέπσλ. 31 νινθιεξσκέλεο απφ ηηο νπνίεο ζε 16 Δπηβιέπσλ. 1. Uygar H. Tazebay: «Analyse mutationelle et etude de la regulation du gene prnB implique dans le transport de la proline chez Aspergillus nidulans», 1998. 2. σηήξεο Ακίιιεο: «Ο Aspergillus nidulans σο πξφηππν ζχζηεκα γηα ηε κειέηε κεηαθνξέσλ πνπξηλψλ», 2004. Δπιβλέπφν 3. Μαξίλα Κνπθάθε: «Μνξηαθή θαη ιεηηνπξγηθή αλάιπζε γνληδίσλ θιηληθήο θαη θαξκαθνινγηθήο ζεκαζίαο ζε πξφηππα κηθξνβηαθά ζπζηήκαηα», 2004. Δπιβλέπφν 4. Καιιηφπε Υάιθνπ: «Μειέηε ηνπ ξφινπ ησλ αθηηλνβαθηεξίσλ θαη άιισλ ελδνγελψλ βαθηεξηαθψλ πιεζπζκψλ ζηε βηναπνηθνδφκεζε πεηξειατθψλ απνβιήησλ», 2005 5. Υξήζηνο Μετληάλεο: «Μειέηε Πνηθηιφηεηαο Πξνθαξπσηηθψλ Οξγαληζκψλ», 2005 6. Εσή Δξπαπάδνγινπ, «Μειέηε ησλ ζπζηεκάησλ πξφζιεςεο λνπθιενηηδηθψλ βάζεσλ ζε παζνγφλα πξσηφδσα», 2006. σν-επιβλέπφν 7. Αξεηή Παληαδνπνχινπ: «Αλαδεηψληαο γνλίδηα-παξάγνληεο έιεγρνπ ηεο ελδνθπηηαξηθήο ζηφρεπζεο ησλ κεηαθνξέσλ πνπξηλψλ ζηνλ Aspergillus nidulans», 2006. Δπιβλέπφν 8. νθία Γθνπληέια: «Μειέηε κεηαθνξέσλ λνπθιενηηδηθψλ βάζεσλ ηνπ παζνγφλνπ κχθεηα Candida albicans», 2006. Δπιβλέπφν 9. Παλαγηψηα Καξαηδά: «Αλάπηπμε ελφο πξφηππνπ βαθηεξηαθνχ ζπζηήκαηνο γηα ηε κειέηε ησλ ζρέζεσλ δνκήο-ιεηηνπξγίαο ζηνπο κεηαθνξείο λνπθιενηηδηθψλ βάζεσλ αζθνξβηθνχ (NAT transporters)», 2006. 10. Isabel Joao Soares da Silva (Universidade do Minho, Πνξηνγαιία): «Characterization of monocarboxylate permeases in yeast- functional and structural analysis», 2006. σνεπιβλέπφν 11. Διέλε Γηαλλνχηζνπ, «Αμηνπνίεζε απνβιήησλ ειαηνπξγείνπ κέζσ κηθξνβηαθψλ δπκψζεσλ», 2007. 12. Maria Laura Harispe Francolino: «Etudes sur la topogenese des transporteurs des purines et des acides aminees chez Aspergillus nidulans», 2007. 13. Njimoh Dieudonne Lemuh: «Απνκφλσζε θαη θαζαξηζκφο δηακεκβξαληθψλ πξσηετλψλ κπθήησλ», 2007. σν-επιβλέπφν 14. Γεκεηξνχια Σζίξε: «Ρχζκηζε ηεο παξαγσγήο θπηναιεμηλψλ απφ θπηά θαη ηζηνθαιιηέξγεηεο ςπραλζψλ», 2008. 15. Νηθφιανο Γνιαςάθεο: «πζηεκαηηθή θαη Οηθνινγία Μηθξνθπθψλ», 2008. 16. Βαζηιηθή Φαιάξα: «Λεηηνπξγηθή γελσκαηηθή αλάιπζε ησλ αδεληθψλ ηξηρψλ ηνπ Cistus creticus spp creticus», 2008. 17. Άλλα Βιαληή: «ρέζεηο-δνκήο ιεηηνπξγίαο ζηνπο κεηαθνξείο πνπξηλψλ κπθήησλ», 2009. Δπιβλέπφν 18. Γηάλλεο Παπαγεσξγίνπ: «Μειέηε ησλ ζπζηεκάησλ πξφζιεςεο λνπθιενηηδηθψλ βάζεσλ ζηo παζνγφλν παξάζηην Leishmania», επηβιέπσλ, 2009. Δπιβλέπφν 19. Γψξα Κνξάθε: Μνξηαθή πιεζπζκηαθή αλάιπζε ηξεπηνκπθήησλ εδάθνπο κεζνγεηαθνχ ηχπνπ-Μειέηε θπζηθψλ πιαζκηδίσλ, 2009. 20. Γεψξγηνο Μεξκειέθαο: «Τπεξέθθξαζε-θαζαξηζκφο θαη κειέηε ζρέζεσλ δνκήοιεηηνπξγίαο ησλ κεηαθνξέσλ NAT ζε πξφηππν βαθηεξηαθφ ζχζηεκα», 2009. 21. Γέζπνηλα Λπκπεξνπνχινπ: «Μειέηε ηεο πνηθηιφηεηαο ησλ βαθηεξίσλ ηερλεηήο ιίκλεο: πνηνηηθή θαη πνζνηηθή επνρηαθή δηαθχκαλζε ησλ κηθξνβηαθψλ πιεζπζκψλ», 2009. 22. Γήκεηξα Μπνπδαξέινπ: «Κισλνπνίεζε & ιεηηνπξγηθφο ραξαθηεξηζκφο πξσηετλψλ ηνπ Aspergillus nidulans νκφινγσλ ησλ εμπαλζηλψλ ησλ αλψηεξσλ θπηψλ», 2010. Δπιβλέπφν 23. Γεψξγηνο Αλαζνληδήο: «Γελεηηθή ηξνπνπνίεζε ηνπ κχθεηα Fusarium oxysporum κε ζηφρν ηε δεκηνπξγία ζηειερψλ κε απμεκέλε παξαγσγηθφηεηα αηζαλφιεο», 2010. σνΔπιβλέπφν 10 24. Αξηζηείδεο Εσγξαθίδεο: «Μνξηαθή αλάιπζε θαη ξφινο ηνπ γνληδίνπ PESCADILLO ζηελ θπηηαξηθή αλάπηπμε θαη δηαθνξνπνίεζε», 2011. 25. Κσλζηαληίλνο Παπαθψζηαο,: «Γηεξεχλεζε ηνπ κεραληζκνχ πξφζιεςεο πνπξηλψλ απφ ηνπο κεηαθνξείο λνπθιενηηδηθψλ βάζεσλ-αζθνξβηθνχ (NAT)», 2011. 26. Υξήζηνο Γνπξλάο: «Μειέηε ηεο έθθξαζεο θαη ζρέζεηο δνκήο-ιεηηνπξγίαο κεηαθνξέσλ πνπξηλψλ», 2011. Δπιβλέπφν 27. Αηθαηεξίλε Γεσξγνπνχινπ: «Υαξηνγξάθεζε ηνπ θέληξνπ δέζκεπζεο θαη κεηαθνξάο πνπξηλψλ ησλ κεηαθνξέσλ λνπθιενηηδηθψλ βάζεσλ-αζθνξβηθνχ (NAT)». 2011. 28. Παλαγηψηα ηαζνπνχινπ: «Βηνζχλζεζε πδξνιπηηθψλ ελδχκσλ απφ ζεξκφθηινπο κηθξννξγαληζκνχο», 2012. 29. Βαζηιηθή Κσζηή, «Γελεηηθέο θαη κνξηαθέο πξνζεγγίζεηο ζρέζεσλ δνκήο-ιεηηνπξγίαο δηακεκβξαληθψλ κεηαθνξέσλ πνπξηλψλ». 2013. Δπιβλέπφν 30. Γεσξγία-Μαξία Καξαράιηνπ, «Μειέηε ησλ ξπζκηζηηθψλ κεραληζκψλ ζηφρεπζεο θαη ελδνθχησζεο δηακεκβξαληθψλ κεηαθνξέσλ πνπξηλψλ ζε έλα πξφηππν γελεηηθφ ζχζηεκα». 2013. Δπιβλέπφν 31. Joana Sa Pesoa (Universidade do Minho, Πνξηνγαιία). 2013. σν-επιβλέπφν. 32. Βαζίιεηνο Νηάλνο, «Δθαξκνγέο in silico κεζφδσλ ζε κηθξννξγαληζκνχο ηαηξηθνχ ελδηαθέξνληνο, κε ζθνπφ ηνλ εληνπηζκφ πξσηετληθψλ αιιειεπηδξάζεσλ». Δπιβλέπφν, 201133. Αηκηιία Κξππσηνχ. «ρέζεηο δνκήο-ιεηηνπξγίαο θαη εμειηθηηθέο ζρέζεηο κεηαθνξέσλ πνπξηλψλ ηεο νηθνγέλεηαο NCS1». Δπιβλέπφν, 201234. Μίλσο Δπαγγειηλφο, «Μειέηε κεραληζκψλ κεκβξαληθήο δηαθίλεζεζεο & ελδνθχησζεο ζηνλ Aspergillus nidulans». Δπιβλέπφν, 201335. Φνίβνο Μπνξκπφιεο. «Ο ξφινο παξαγφλησλ κεηαβνιηζκνχ mRNA ζηε γήξαλζε θαη ηε θπζηνινγία ηνπ λεκαηψδνπο C. Elegans» Δπιβλέπφν, 201436. Διπηλίθε Νίλνπ. «Ο ξφινο ησλ κεγάισλ RNAs πνπ δελ θσδηθνπνηνχλ γηα πξσηεΐλεο (lncRNAs) ζηελ αλάπηπμε ηνπ εγθεθάινπ ησλ ζειαζηηθψλ». Δπιβλέπφν, 201437. Οιγα Μαξηδνχθνπ. «Μειέηε ηεο θπηηαξηθήο δηαθίλεζεο, ελδνθχηησζεο θαη απνδφκεζεο κεκβξαληθψλ πξσηετλψλ κέζσ ηεο αλάπηπμεο λέσλ γελεηηθψλ θαη βηνρεκηθψλ πξνζεγγίζεσλ» Δπιβλέπφν, 2014Alumni - ημερινή Θέζη Γιδακηόρφν (σπό ηην επίβλευη μοσ) Uygar H. Tazebay, Αλαπιεξσηήο θαζεγεηήο ζην Bilkent University, Ankara σηήξεο Ακίιιεο, Σκήκα Βηνινγίαο, Σνκέαο Βνηαληθήο, ΔΚΠΑ Μαξίλα Κνπθάθε, Σερληθφο έξεπλαο, Ηλζηηηνχην Μνξηαθήο Βηνινγίαο, ΗΣΔ, Ζξάθιεην Αξεηή Παληαδνπνχινπ, Τπφηξνθνο FEBS (Long-term fellowships 2007-2010), Δξεπλήηξηα (2010- ), Centro de Investigaciones Biologicas CSIC, Madrid, Spain νθία Γθνπληέια, Δξεπλήηξηα, University of California Los Angeles, Sweden (2009- ) Γηάλλεο Παπαγεσξγίνπ, Μεηαδηδαθηνξηθφο εξεπλεηήο, Washington University, Seattle, USA (2009- ) Njimoh Dieudonne Lemuh, Λέθηνξαο, University of Yaounde, Cameroon (2010- ) Γήκεηξα Μπνπδαξέινπ, Δξγαδφκελε ζην Μαηεπηήξην «Μεηέξα». Άλλα Βιαληή, Μεηαδηδαθηνξηθφο Δξεπλεηήο, ΗΒΔΑΑ, Δξγαζηήξην Κ. πληηράθε. (2010- ) Γεψξγηνο Αλαζνληδήο, Μεηαδηδαθηνξηθφο Δξεπλεηήο, Chalmers University, Goettenborg, νπεδία. 2010Isabel Joao Soares da Silva, Δξεπλήηξηα, Faculdade de Medicina da Universidade do Porto, Πνξηνγαιία. 2010Υξήζηνο Γνπξλάο, Μεηαδηδαθηνξηθφο Δξεπλεηήο, ΔΚΔΦΔ Γεκόθξηηνο, Σκήκα Βηνινγίαο, Δξγαζηήξην Β. νθηαλνπνχινπ. (2012- ) 11 ΔΡΔΤΝΗΣΙΚΟ ΔΡΓΟ Υρημαηοδοηήζεις Πποζωπικέρ σπημαηοδοηήζειρ 1985-1986 1986-1988 1995-1996 1997-1998 Γηδαθηνξηθή ππνηξνθία ηνπ Ηδξχκαηνο Ωλάζε Δπξσπατθή ππνηξνθία γηα δηδαθηνξηθέο ζπνπδέο ("Action") Μεηαδηδαθηνξηθή ππνηξνθία Δπξσπατθήο Έλσζεο (TMR)- Marie Curie Μεηαδηδαθηνξηθή ππνηξνθία Δπαλαπαηξηζκνχ Δπξσπατθήο Έλσζεο. (“Return”) -Marie Curie Δπεςνηηικέρ Χπημαηοδοηήζειρ 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. ΔΚΔΦΔ Γεκφθξηηνο, ΓΖΜΟΔΡΔΤΝΑ (1999), Δ.Τ: Β. νθηαλνπνπινπ Δζληθφ θαη Καπνδηζηξηαθφ Παλεπηζηήκην Αζελψλ, ΚΑΠΟΓΗΣΡΗΑ (1999-2007), Δ.Τ: Γ. Γηαιιηλάο ΠΔΝΔΓ 2001. «Κισλνπνίεζε θαη κειέηε κεηαθνξέσλ λνπθιενηηδηθψλ βάζεσλ κε απψηεξν ζθνπφ ηε ζπζηεκαηηθή αλάπηπμε λέσλ θαξκάθσλ πςειήο εμεηδίθεπζεο έλαληη κνξίσλ-ζηφρσλ παζνγφλσλ πξσηφδσσλ». Δ.Τ: Γ. Γηαιιηλάο Κνηλά Δξεπλεηηθά θαη Σερλνινγηθά Πξνγξάκκαηα ΠΛΑΣΩΝ: Διιάδα – Γαιιία 20002001. «Υξήζε ηνπ κχθεηα Aspergillus nidulans σο πξφηππν γελεηηθφ θαη κνξηαθφ ζχζηεκα γηα ηε κειέηε δηακεκβξαληθψλ πξσηετληθψλ κεηαθνξέσλ λνπθιενηηδηθψλ βάζεσλ απφ ηνλ άλζξσπν» Δ.Τ: Γ. Γηαιιηλάο, C. Scazzocchio (Institute of Genetics and Microbiology, Centre d' Orsay, University of Paris-XI) Κνηλά Δξεπλεηηθά θαη Σερλνινγηθά Πξνγξάκκαηα ΠΛΑΣΩΝ: Διιάδα – Γαιιία 20022003. «Purine transporters as key molecules for the targeted pharmacological of Candida albicans». Δ.Τ: Γ. Γηαιιηλάο ΔΠΔΑΔΚ-ΠΤΘΑΓΟΡΑ ΗΗ, 2003-2006, Τπ. Παηδείαο¨, Γ.Γ.Δ.Σ : «Structure-Function relationships of nucleobase transporters for the systematic development of antimicrobial drugs». Δ.Τ: Γ. Γηαιιηλάο Πξφγξακκα ΠΔΝΔΓ2003, έξγν 03ΔΓ/204, 2005-2009. «Μειέηε ησλ ζρέζεσλ δνκήοιεηηνπξγίαο ζηνπο κεηαθνξείο πνπξηλψλ γηα ηελ ζπζηεκαηηθή θαη ζηνρεπκέλε θαξκαθνινγηθή αληηκεηψπηζε παζνγφλσλ κπθήησλ». Δ.Τ: Γ. Γηαιιηλάο Πξφγξακκα ΠΔΝΔΓ2003, έξγν 03ΔΓ/183, 2005-2009. «Αξηζηνπνίεζε ηεο παξαγσγήο βηναηζαλφιεο απφ αλαλεψζηκεο ιηγληλνθπηηαξηλνχρεο πεγέο κε ηελ ρξήζε εξγαιείσλ κεηαβνιηθήο κεραλήο». Δπηζηεκνληθή θαη Σερλνινγηθή πλεξγαζία Διιάδαο-Γεξκαλίαο 2004-2007. «Invasive Aspergillosis: Identification of Fungal Proteins Suited as Specific Drug Gateways». Δ.Τ: Γ. Γηαιιηλάο, U. Reihardt (Department of Medical Microbiology, University Hospital of Göttingen) Δζληθφ θαη Καπνδηζηξηαθφ Παλεπηζηήκην Αζελψλ, ΚΑΠΟΓΗΣΡΗΑ 2006: Μειέηε ησλ ζρέζεσλ δνκήο-ιεηηνπξγίαο ηνπ κεηαθνξέα αδελίλεο-ππνμαλζίλεο-γνπαλίλεο AzgA ζηνλ πξφηππν αζθνκχθεηα Aspergillus nidulans. Δ.Τ: Γ. Γηαιιηλάο ΓΓΔΣ, Πξφγξακκα ΔΠΑΝ-Μέηξν 4.3, πλεξγαζίεο κε Δ & Σ Οξγαληζκνχο ρσξψλ εθηφο Δπξψπεο, 2005-2008, Έξγν 05-NONEU-547, «Υαξηνγξάθεζε ηνπ θέληξνπ δέζκεπζεο ησλ κεηαθνξέσλ λνπθιενηηδηθψλ βάζεσλ –αζθνξβηθνχ (ΝΑΣ) γηα ηελ αλάπηπμε ζηνρεπκέλσλ εθαξκνγψλ θαξκάθσλ» (Mapping the binding site of nucleobase-ascorbate transporters for the development of targeted drug treatments). E.Y: Δ. Φξηιιίγγνο (Παλ. Ησαλλίλσλ). Δζληθφ θαη Καπνδηζηξηαθφ Παλεπηζηήκην Αζελψλ, ΚΑΠΟΓΗΣΡΗΑ 2008: «Δπίδξαζε ηνπ ελδχκνπ ιηγάζε ηεο νπβηθνπηηίλεο ζηνπο κεραληζκνχο ελδνθχησζεο κεηαθνξέσλ ζην κχθεηα Aspergillus nidulans». Δ.Τ: Γ. Γηαιιηλάο 12 12. 13. 14. 15. 16. 17. Δπηζηεκνληθέο Μειέηεο 2011. «ρεδηαζκφο ζηνρεπκέλσλ θαξκάθσλ θαηά ησλ κπθεηηαθψλ παζνγφλσλ», ζηα πιαίζηα Πξνγξάκκαηνο ηνπ Κνηλσθεινχο Ηδξχκαηνο Ησάλλε . Λάηζε. Δ.Τ: Γ. Γηαιιηλάο Δπηρεηξεζηαθφ Πξφγξακκα Δθπαίδεπζε θαη Γηα Βίνπ Μάζεζε (ΔΠΑ 2007-2013) Τπνπξγείν Δζληθήο Παηδείαο θαη Θξεζθεπκάησλ. «ΖΡΑΚΛΔΗΣΟ ΗΗ-188, «Γελεηηθέο, Μνξηαθέο, Βηνρεκηθέο Καη Βηνθπζηθέο Πξνζεγγίζεηο ρέζεσλ Γνκήο-Λεηηνπξγίαο Γηακεκβξαληθψλ Μεηαθνξέσλ Πνπξηλψλ». Δ.Τ: Γ. Γηαιιηλάο Δπηρεηξεζηαθφ Πξφγξακκα Δθπαίδεπζε θαη Γηα Βίνπ Μάζεζε (ΔΠΑ 2007-2013) Τπνπξγείν Δζληθήο Παηδείαο θαη Θξεζθεπκάησλ. «ΖΡΑΚΛΔΗΣΟ ΗΗ-193, «Μειέηε Σσλ Ρπζκηζηηθψλ Μεραληζκψλ ηφρεπζεο & Δλδνθχησζεο Γηακεκβξαληθψλ Μεηαθνξέσλ Πνπξηλψλ ε Έλα Πξφηππν Γελεηηθφ χζηεκα». Δ.Τ: Γ. Γηαιιηλάο Δπηρεηξεζηαθφ Πξφγξακκα Δθπαίδεπζε θαη Γηα Βίνπ Μάζεζε (ΔΠΑ 2007-2013), Τπνπξγείν Δζληθήο Παηδείαο θαη Θξεζθεπκάησλ. «ΘΑΛΖ-EVOTRANS, Γηακεκβξαληθή κεηαθνξά: ζρέζεηο δνκήο-ιεηηνπξγίαο θαη εμέιημεο». Δ.Τ: Δ. Φξηιιίγγνο (ΠΗ Ηαηξηθή ρνιή), Β. νθηαλνπνχινπ (ΔΚΔΦΔ Γεκφθξηηνο, Σκ. Βηνινγίαο), Ν. Πνχιε (ΔΚΠΑ, Σκ. Φαξκαθεπηηθήο), Κ. Γξαΐλαο (ΠΗ, Σκ. Υεκείαο) Δπηρεηξεζηαθφ Πξφγξακκα Δθπαίδεπζε θαη Γηα Βίνπ Μάζεζε (ΔΠΑ 2007-2013), Τπνπξγείν Δζληθήο Παηδείαο θαη Θξεζθεπκάησλ. «ΘΑΛΖ-MINOS, Αλάπηπμε ηερλνινγηψλ γνληδησκαηηθήο θαη γελεηηθήο αλάιπζεο κε ην κεηαζεηφ ζηνηρείν Minos θαη εθαξκνγέο ηνπο ζε νξγαληζκνχο-κνληέια». Δπηζηεκνληθνί ππεχζπλνη: Υ. αββάθεο (ΔΚΔΒΔ Φιέκηλγθ, Ηλζη. Κπηηαξηθήο θαη Αλαπηπμηαθήο Βηνινγίαο), Μ. Αβέξσθ (IMBB-ΗΣΔ, Ηλζηηηνχην Μνξηαθήο Βηνινγίαο θαη Βηνηερλνινγίαο), Γ. Γηαιιηλάο Δπηρεηξεζηαθφ Πξφγξακκα Δθπαίδεπζε θαη Γηα Βίνπ Μάζεζε (ΔΠΑ 2007-2013) Τπνπξγείν Δζληθήο Παηδείαο θαη Θξεζθεπκάησλ. «Δλίζρπζε Μεηαδηδαθηφξσλ Δξεπλεηψλ / Σξηψλ, Unraveling the specific pathways & mechanisms involved in transporter trafficking in a model genetic system». Δ.Τ: Γ. Γηαιιηλάο. Η σπουήθια δεν δέτηηκε ηελικά ηη θέζη. Κριηής-Δπιηροπές-Μέλος Δηαιριών Κξηηήο ζηα πεξηνδηθά Science, Molecular Microbiology, Journal of Microbiology, Molecular General Genetics (Molecular Genetics and Genomics), PlosOne, PeerJ, FEMS Microbiology Reviews, Fungal Genetics and Biology, Applied Microbiology and Biotechnology θαη FEMS Yeast Research Κξηηήο ζε πξνγξάκκαηα ηεο Γεληθή Γξακκαηείαο Έξεπλαο θαη Σερλνινγίαο (ΓΓΔΣ), ηνπ Τπνπξγείνπ Αλάπηπμεο (ζηα πιαίζηα δηαθξαηηθψλ ζπλεξγαζηψλ κε θνξείο κε– επξσπατθψλ ρσξψλ θαη ζε πξνγξάκκαηα ΠΔΝΔΓ) Κξηηήο ζε πξνγξάκκαηα ηνπ Aκεξηθαληθνχ (USDA) θαη νπεδηθνχ Τπνπξγείνπ Γεσξγίαο Κξηηήο γηα πιήξσζε εξεπλεηηθήο ζέζεο ζην ΔΟΦ (2003) Κξηηήο ππνηξνθηψλ Η.Κ.Τ. Πξνεδξεχσλ ζηα ζπλέδξηα 2nd International Symposium on Nitrogen Metabolism of Ascomycetes, Hacienda Vista Hermosa, Mexico (1997), 5th European Conference on Fungal Genetics, Arcachon, France (2000), Παλειιήλην πλέδξην ΠΔΒ. "Μνξηαθή Βηνινγία - Κπηηαξνγελεηηθή ζηελ Τγεία (2000) Μέινο ηνπ εθδνηηθνχ ζπκβνπιίνπ (editorial board) ησλ πεξηνδηθψλ Molecular Membrane Biology, World Journal of Biologiucal Chemistry θαη Advances in Biology. Μέινο ησλ επηζηεκνληθψλ εηαηξεηψλ ΠΔΒ, ΔΔΒΔ, ΔΔΒΜΒ, θαη ηεο American Association for the Αdvancement of Science Μέινο ηεο Biophysical Society-USA 2010 Μέινο ηεο Biochemical Society-FEBS 2013 13 Γιακρίζεις-Βραβεία Δπξσπατθφ βξαβείν «Αρτιμήδης» 2002 γηα ηε ρξεκαηνδφηεζε θνηηεηψλ πηπρίνπ γηα ηε ζπλέρηζε ηεο αθαδεκατθήο ή επαγγεικαηηθήο ηνπο ζηαδηνδξνκίαο. Οη θνηηεηέο Κ. Καγηάο, Α. Παληαδνπνχινπ, . Σνπξλαβίηε θαη . Γθνπληέια, πνπ πξαγκαηνπνίεζαλ ηελ δηπισκαηηθή ηνπο εξγαζία ππφ ηελ άκεζε επίβιεςε κνπ, θέξδηζαλ ην πξψην βξαβείν (44.000 Δσρώ). Σα βξαβεία (ηξία γηα φιε ηελ Δπξψπε γηα φιεο ηηο επηζηήκεο) απηά δίδνληαη κε βάζε ηηο δηπισκαηηθέο εξγαζίεο θαη ηνλ κειινληηθφ ζρεδηαζκφ ησλ κεηαπηπρηαθψλ ζπνπδψλ (http://ec.europa.eu/research/press/2002/pr0512_1en.html). Δπηζθέπηεο Καζεγεηήο ζηελ “Ciudad del Saber”, Νέν Παλεπηζηήκην-Δξεπλεηηθφ Κέληξν ζηνλ Παλακά (http://www.sanmartin.edu.co/ciudaddelsaber/docentes.php) απφ ην 2001-2006 Δπηζθέπηεο Καζεγεηήο ζηo Departamento de Biologia da Universidade do Minho, Portugal 2006-2009 Σξία πξφζθαηα άξζξα (M. Koukaki, A. Vlanti, S. Goudela, A. Pantazopoulou, H. Gioule, S. Tournaviti and G. Diallinas J Mol Biol., 350(3):499-513, Cecchetto G, Amillis S, Diallinas G, Scazzocchio C, Drevet C. 2004. J Biol Chem, 279: 3132-3141 θαη I. Papageorgiou, C. Gournas , A. Vlanti , S. Amillis , A. Pantazopoulou and G. Diallinas G. 2008. J Mol Biol. 382:1121-1135) επηιέρζεθαλ απφ ηελ BioMed Central (www.faculty of1000.com) λα αλαθέξνληαη ζε πξνηεηλφκελε ιίζηα ελδηαθεξφλησλ άξζξσλ Biophysical Society Announces Winners of 2011 International Travel Awards Υξεκαηνδνηηθφ Βξαβείν γηα πξφηππε έξεπλα ηνπ John S. Latsis Public Benefit Foundation 2011 (http://www. foundation.org/en/14/projects.html) Οργάνφζη σνεδρίοσ Σν SMYTE (Small Meeting on Yeast Transport and Energetics) είλαη δηεζλέο ζπλέδξην ην νπνίν αθνξά ζηε βηνινγία γνληδίσλ θαη πξσηετλψλ πνπ ειέγρνπλ ηελ επηθνηλσλία ησλ θπηηάξσλ κε ην πεξηβάιινλ ηνπο. Καηά ηελ δηάξθεηα ηνπ 18νπ Γηεζλνχο πλεδξίνπ SMYTE πνπ πξαγκαηνπνηήζεθε ζηηο 14-17 επηεκβξίνπ 2000 ζην Οχξν Πξέην (Βξαδηιία) κνπ αλαηέζεθε ε δηνξγάλσζε ηνπ 19νπ ζπλεδξίνπ SMYTE, ην νπνίν πξαγκαηνπνηήζεθε ζηηο εγθαηαζηάζεηο ηνπ Μεζνγεηαθνχ Αγξνλνκηθνχ Ηλζηηηνχηνπ Υαλίσλ (ΜΑΗΥ), ζηα Υαληά Κξήηεο απφ ηηο 14 έσο ηηο 17 επηεκβξίνπ 2001. πκκεηείραλ 100 εξεπλεηέο απφ ηε δηεζλή επηζηεκνληθή θνηλφηεηα, θαζψο θαη αλαγλσξηζκέλνη επηζηήκνλεο απφ ηνλ Διιαδηθφ ρψξν. Γιεθνείς προθορικές παροσζιάζεις μεηά από πρόζκληζη (ηελεσηαίφν 10 εηών) 1. 21st International Conference on Yeast Genetics & Molecular Biology, Gothenburg Sweden, 2003 2. Faculty of Medicine, University of Gottingen, Gottingen, Germany, 2005 3. Faculty of Biology, University of Minho, Braga, Portugal, 2006 4. Advanced course on Plasma membrane transporters: Physiology, Genetics and Phylogeny 2 nd edition, Braga, Portugal, 2007 5. 'Horizons in Molecular Biology and Genetics' Symposium, Bilkent University, Ankara, 2008 6. Eurofungbase Meeting, LSSG-CT-2005-018964, San Feliu de Guixols, Spain, 2008 7. Imperial College, London, UK, 2008 8. 26th Smyte (Small Meeting on Yeast Transport and Energetics), Braga, Portugal, 2008 9. EMBO/FEBS lecture Course Channels and Transporters, Ettore Majorana Foundation and Center for Scientific Culture, Erice, Sicily, Italy, 2008 10. Faculty of Pharmacy, University of Bonn, Bonn, Germany, 2009 11. CIB-CSIC, Madrid, Spain, 2010 14 12. Eurofungbase Meeting, Wagenigen, Holland, 2009 13. Advanced course on Plasma membrane transporters: Physiology, Genetics and Phylogeny 3 nd edition, Braga, Portugal, 2010 14. Advanced course on Plasma membrane transporters: Physiology, Genetics and Phylogeny 4 nd edition, Braga, Portugal, 2012 15. Eurofungbase Meeting, Berlin, Germany, 2012 16. 3rd International Workshop on Expression, Structure and Function of Membrane Protein, Florence, Italy, 2012 17. FEBS Special Meeting in Protein Quality Control and Ubiquitin Systems in health and disease, Kusadasi, Turkey 2012 18. 27th Fungal Genetics Conference at Asilomar, Membrane trafficking and molecular organization, Asilomar, CA, USA, 201 19. Marcelle Grenson opening lecture in 31st Smyte (Small Meeting on Yeast Transport and Energetics), Antalya, Turkey, September 2013 (Distinct mechanisms control ubiquitination and turnover of the UapA transporter in response to physiological signals or protein misfolding). 20. 1st Meeting of the Turkish Society of Molecular Biology, Instambul, Turkey, November 2013 (How transporters function; Lessons for a model fubngal system) 21. Lab Physiologie Moléculaire de la Cellule, ULB - Institut de Biologie et de Médecine Moléculaires 6041 Gosselies, Belgium, 18 March 2014 22. 12th European conference on fungal genetics, Seville, March 23-27, 2014 23. Institute of Botany and Microbiology, Department of Biology KU Leuven, Flanders, Belgium, April 2014 24. Karlsruhe Institute of Technology, Dept. of Microbiology, Karlsruhe, Germany, July 2014 Sabbatical-Δρεσνηηική Άδεια 1. Φεβξνπάξηνο 2005-Απξίιηνο 2005, Δξγαζηήξην Γελεηηθήο & Αλαπηπμηαθήο Βηνινγίαο, Καζ. Υ. Γειηδάθε, ΗΜΒΒ, ΗΣΔ, Ζξάθιεην, Κξήηε, Διιάδα 2. επηέκβξηνο 2009 - Μάξηηνο 2010-Facultade de Biologia, Univesidade do Minho, Μπξάγθα, Πνξηνγαιία, Δξγαζηήξην Γελεηηθήο θαη Βηνηερλνινγίαο, Καζ. Μ. Casal Μεηάκληζη-Δκπαίδεσζη Δρεσνηηών Dr. Gianna Cecchetto (post doc) Dr. Veronica Maurinio (post doc) MSc Ozge Canli PhD Isabel Soares Silva PhD Isabel Soares Silva PhD Isabel Soares Silva MSc Esra Karakose Dr. Γηάλλεο εξαθεηκίδεο (post doc) PhD Joana Sa Pesoa PhD Joana Sa Pesoa PhD Joana Sa Pesoa (Οπξνπγνπάε-Γαιιία) (Αξγεληηλή-Γεξκαλία) (Σνπξθία) (Πνξηνγαιία) (Πνξηνγαιία) (Πνξηνγαιία) (Σνπξθία) (Διιάδα) (Πνξηνγαιία) (Πνξηνγαιία) (Πνξηνγαιία) 1 κήλαο 3 κήλεο 1 κήλαο 3 κήλεο 1 εβδνκάδα 1 εβδνκάδα 9 κήλεο 9 κήλεο 4 κήλεο 2 κήλεο 1 κήλα 2001 2002 2003 2003 2005 2008 2005-2007 2005-2006 2010 2011 2013 15 ΓΗΜΟΙΔΤΔΙ Γιεθνή πεπιοδικά με κπιηέρ (Pubmed) 1. G. Diallinas and C. Scazzocchio, 1989. A gene coding for the uric acid-xanthine permease of Aspergillus nidulans: inactivational cloning, characterization and sequence of a cis-acting mutation. Genetics, 122: 341-350 2. V. Sophianopoulou, T. Suarez, G. Diallinas and C. Scazzocchio, 1993. Operator derepressed mutants in the proline utilisation cluster of Aspergillus nidulans. Mol Gen Genet, 236: 209213 3. V. Sophianopoulou and G. Diallinas, 1993. AUA1, a gene involved in ammonia regulation of amino acid transport in Saccharomyces cerevisiae. Mol Microbiol, 8: 167-178 4. L. Gonfinkiel, G. Diallinas and C. Scazzocchio, 1993. Sequence and regulation of the uapA gene, encoding a uric acid-xanthine permease in the fungus Aspergillus nidulans. J Biol Chem, 268: 23376-23381 5. G. Diallinas and G. Thireos, 1994. Genetic and Biochemical evidence for GCN2 protein kinase polymerization. Gene, 143: 21-27 6. G. Diallinas and A. Kanellis, 1994. A phenylalanine ammonia-lyase gene from melon fruit: cDNA cloning, sequence and expression in response to development and wounding. Plant Mol Biol, 26: 473-479 7. U. H. Tazebay, V. Sophianopoulou, C. Scazzocchio, A. Rosa and G. Diallinas, 1994. Structure-Function Analysis of the Proline Permease (PRNB) of the Filamentous Fungus Aspergillus nidulans. Folia Microbiol, 39: 551-553 8. G. Diallinas, L. Gorfinkiel, H. Arst, G. Cecchetto and C. Scazzocchio, 1994. Genetic and Molecular Characterisation of Purine Permease Genes of Aspergillus nidulans Reveals a Novel Family of Transporters Conserved in Prokaryotes and Eukaryotes. Folia Microbiol, 39: 513514 9. G. Diallinas, L. Gorfinkiel, H. Arst, G. Cecchetto and C. Scazzocchio, 1995. Genetic and molecular characterisation of a wide-specificity purine permease of Aspergillus nidulans reveals a novel family of transporters conserved in prokaryotes and eukaryotes. J Biol Chem 270: 8610-8622 10. V. Sophianopoulou and G. Diallinas, 1995. Amino acid transporters of lower eukaryotes: regulation, structure and topogenesis. FEMS Microbiol Rev, 16: 53-75 11. U. H. Tazebay, V. Sophianopoulou, B. Cubero, C. Scazzocchio and G. Diallinas, 1995. Posttranscriptional regulation and kinetic characterization of proline transport in germinating conidiospores of Aspergillus nidulans. FEMS Microbiol Lett, 132: 27-37 12. G. Diallinas, I. Pateraki, M. Sanmartin, A. Scossa, E. Stylianou, N. Panopoulos and A. Kanellis, 1997. Melon ascorbate oxidase: cloning of a multigene family, induction during fruit development and repression by wounding. Plant Mol Biol, 34: 759-770 13. U. H. Tazebay, V. Sophianopoulou, C. Scazzocchio, and G. Diallinas, 1997. The gene encoding the major proline transporter gene of Aspergillus nidulans is upregulated during conidiospore germination and in response to proline induction and amino acid starvation. Mol Microbiol, 24: 105-117 14. A. Ravaganani, L. Gonfinkiel, G. Diallinas, T. Langdon, E. Adjai, S. Demais, D. Gorton, H. N. Arst, Jr. and C. Scazzocchio, 1997. Subtle hydrophobic interactions between the seventh loop amino acid of the Zn finger and the first base of a HGATAR sequence determines promoter specific recognition by the GATA factor of Aspergillus nidulans. EMBO J, 16: 3974-3986 15. G. Diallinas, V. Sophianopoulou, L. Gorfinkiel, G. CecchettoJ., Valdez, A. Rosa and C. Scazzocchio, 1997. Structure-function analysis of purine transporters in Aspergillus nidulans. Folia Microbiol, 42: 260-261 16. G. Diallinas, J. Valdez, V. Sophianopoulou, A. Rosa and C. Scazzocchio, 1998. Chimeric protein analysis reveals a region involved in function and specificity of purine transporters in the filamentous fungus Aspergillus nidulans conserved in bacteria, plants and metazoans. EMBO J, 17: 3827-3837 17. H. De Koning and G. Diallinas, 2000. Nucleobase transporters. Mol Membr Biol, 17: 75-94 16 18. C. Meintanis, A. Karagouni and G. Diallinas, 2000. Amino acid residues N450 and Q449 are critical for the uptake capacity and specificity of UapA, a prototype of a nucleobase-ascorbate transporter family. Mol Membr Biol, 17:47-57 19. J. Valdez-Taubas , G. Diallinas, C. Scazzocchio and A. Rosa, 2000. Protein expression and subcellular localization of the general purine transporter UapC from Aspergillus nidulans. Fungal Genet Biol, 30: 105-113 20. E. Argyrou, V. Sophianopoulou, N. Schultes, and G. Diallinas, 2001. Functional characterization of a maize purine transporter by expression in Aspergillus nidulans. Plant Cell, 13: 953-964 21. P. Ververidis, F. Davrazou, G. Diallinas, D. Georgakopoulos, A. Kanellis and N. Panopoulos, 2001. A novel putative reductase (Cpd1p) and the multidrug exporter Snq2p are involved in resistance to cercosporin and other singlet oxygen-generating photosensitizers in Saccharomyces cerevisiae. Curr Genet, 39: 127-136 22. S. Amillis, M. Koukaki and G. Diallinas, 2001. Substitution F569S converts UapA, a specific uric acid-xanthine transporter, into a broad specificity transporter for purine-related solutes. J Mol Biol, 313: 765-774 23. Tavoularis SN, Tazebay UH, Diallinas G, Sideridou M, Rosa A, Scazzocchio C, Sophianopoulou V, 2003. Mutational analysis of the major proline transporter (PrnB) of Aspergillus nidulans. Mol Membr Biol, 20: 285-97 24. Koukaki M, Giannoutsou E, Karagouni A, Diallinas G, 2003. A novel improved method for Aspergillus nidulans transformation. J Microbiol Methods, 55: 687-695 25. Cecchetto G, Amillis S, Diallinas G, Scazzocchio C, Drevet C, 2004. The AzgA purine transporter of Aspergillus nidulans: characterisation of a protein belonging to a new phylogenetic cluster. J Biol Chem, 279: 3132-3141 26. S. Amillis, G. Cecchetto, V. Sophianopoulou, M. Koukaki, C. Scazzocchio and G. Diallinas, 2004. Transcriptional activation of purine transporters during the conidial isotropic growth phase of Aspergillus nidulans. Mol Microbiol, 52: 205-216 27. I.G Papageorgiou, L. Yakob, M.I. Al Salabi, G. Diallinas, K.P. Soteriadou and H.P. de Koning, 2005. Identification of the first pyrimidine nucleobase transporter in Leishmania: similarities with the Trypanosoma brucei U1 transporter and antileishmanial activity of uracil analogues. Parasitology, 130: 275-83 28. S. Goudela, P. Karatza, M. Koukaki, S. Frillingos and G. Diallinas, 2005. Comparative substrate recognition by bacterial and fungal purine transporters of the NAT/NCS2 family. Mol Membr Biol, 22: 263-275 29. M. Koukaki, A. Vlanti, S. Goudela, A. Pantazopoulou, H. Gioule, S. Tournaviti and G. Diallinas, 2005. The Nucleobase-Ascorbate Transporter (NAT) Signature Motif in UapA Defines the Function of the Purine Translocation Pathway. J Mol Biol, 350: 499-513 30. A. Vlanti, S. Amillis, M. Koukaki, and G. Diallinas, 2006. The last transmembrane segment of UapA, a member of the nucleobase-ascorbate transporter (NAT) family, includes a substrate-selectivity filter and is necessary for ER-exit. J Mol Biol, 357: 808-819 31. S. Goudela, H. Tsilivi and G. Diallinas, 2006. Comparative kinetic analysis of AzgA and Fcy21p, prototypes of the two major fungal hypoxanthine-adenine-guanine transporter families. Mol Membr Biol, 23: 291-303 32. A. Pantazopoulou and G. Diallinas, 2006. The first transmembrane segment (TMS1) of UapA contains determinants necessary for expression in the plasma membrane and purine transport. Mol Membr Biol, 23: 337-248 33. A. Pantazopoulou N.D. Lemuh, D.G. Hatzinikolaou, C. Drevet, G. Cecchetto C. Scazzocchio and G. Diallinas. 2007. Differential physiological and developmental expression of the UapA and AzgA purine transporters in Aspergillus nidulans. Fungal Genet Biol, 44: 627-640 34. S. Amillis, Z. Hamari, K. Roumelioti, C. Scazzocchio and G. Diallinas. 2007. Regulation of Expression and Kinetic Modeling of Substrate Interactions of a Uracil Transporter in Aspergillus nidulans. Mol Membr Biol, 24:206-214 35. A. Pantazopoulou and G. Diallinas, 2007. Fungal Nucleobase transporters. FEMS Microbiol Rev, 31: 657-675 17 36. I. Soares-Silva, S.Paiva, G. Diallinas, and M. Casal. 2007. The conserved sequence NXX[S/T]HX[S/T]QDXXXT of the lactate/pyruvate:H+ symporter subfamily defines the function of the substrate translocation pathway. Mol Membr Biol, 24: 464-474 37. S. Goudela, U. Reichard, S. Amillis and Diallinas G. 2008. Characterization and kinetics of the major purine transporters in Aspergillus fumigatus. Fungal Genet Biol, 45 38. I. Papageorgiou, H.P. De Koning, K. Soteriadou and G. Diallinas. 2008. Kinetic and mutational analysis of the Trypanosoma brucei NBT1 nucleobase transporter expressed in Saccharomyces cerevisiae reveals structural similarities between ENT and MFS transporters. Int J Parasitol, 38: 641-653 39. A. Vlanti and G. Diallinas. 2008. The Aspergillus nidulans FcyB cytosine-purine scavenger is highly expressed during germination and in reproductive compartments and is down-regulated by endocytosis. Mol Microbiol, 68: 959-977 40. C. Gournas, I. Papageorgiou and G. Diallinas. 2008. The Nucleobase-Ascorbate Transporter (NAT) family: Genomics, evolution, structure-function relationships and physiological role. Mol BioSys, 4: 404 – 416 41. I. Papageorgiou, C. Gournas , A. Vlanti , S. Amillis , A. Pantazopoulou and G. Diallinas G. 2008. Specific interdomain synergy in the UapA transporter determines its unique specificity for uric acid among NAT carriers. J Mol Biol. 382:1121-1135 42. G. Diallinas and C. Gournas. 2008. Structure-function relationships in the NucleobaseAscorbate Transporter (NAT) family: Lessons from model microbial genetic systems. Channels, 2, 363-372. 43. G. Diallinas. Biochemistry. 2008. An almost-complete movie. Science. 12:1644-5. 44. N.D. Lemuh, G. Diallinas, S. Frillingos, G. Mermelekas, A.D. Karagouni and D.G. Hatzinikolaou. 2009. Purification and partial characterization of the xanthine-uric acid transporter (UapA) of Aspergillus nidulans. Protein Expr Purif. 63:33-39 45. Hamari Z, Amillis S, Drevet C, Apostolaki A, Vágvölgyi C, Diallinas G, Scazzocchio C. 2009. Convergent evolution and orphan genes in the Fur4p-like family and characterisation of a general nucleoside transporter in Aspergillus nidulans. Mol Microbiol. 73:43-57. 46. Vangelatos I, Vlachakis D, Sophianopoulou V, Diallinas G. 2009. Modelling and mutational evidence identify the substrate binding site and functional elements in APC amino acid transporters. Mol Membr Biol 26:356-370. 47. Gournas C, Amillis S, Vlanti A and Diallinas G. 2010. Transport-dependent endocytosis and turnover of a uric acid-xanthine permease. Mol Microbiol. 75:246-260 48. Conde A, Diallinas G, Chaumont F, Chaves M, Gerós H. 2010. Transporters, channels, or simple diffusion? Dogmas, atypical roles and complexity in transport systems. Int J Biochem Cell Biol. 42(6):857-68. 49. Leung J, Karachaliou M, Alves C, Diallinas G and Byrne, B. 2010. Expression and purification of a functional uric acid-xanthine transporter (UapA) Protein Expr Purif. 72(1):139-46. 50. Kosti V, Papageorgiou I and Diallinas G. 2010. Dynamic elements at both cytoplasmic- and extracellular-facing sides of the UapA transporter selectively control the accessibility of substrates to their translocation pathway. J Mol Biol. 397(5):1132-43. 51. Elsen S, Efthymiou G, Peteinatos P, Diallinas G, Kyritsis P, Moulis JM. 2010. A bacteriaspecific 2[4Fe-4S] ferredoxin is essential in Pseudomonas aeruginosa. BMC Microbiol. 10:271 52. Bitsikas V, Karachaliou M, Gournas C, Diallinas G. 2011. Hypertonic conditions trigger transient plasmolyis, growth arrest and blockage of transporter endocytosis in Aspergillus nidulans and Saccharomyces cerevisiae. Mol Membr Biol. 28(1):54-68. 53. Anasontzis GE, Zerva A, Stathopoulou PM, Haralampidis K, Diallinas G, Karagouni AD, Hatzinikolaou DG. 2011. Homologous overexpression of xylanase in Fusarium oxysporum increases ethanol productivity during consolidated bioprocessing (CBP) of lignocellulosics. J Biotechnol. 152(1-2):16-23 54. Gournas C, Oestreicher N, Amillis S, Diallinas G, Scazzocchio C. 2011. Completing the purine utilisation pathway of Aspergillus nidulans. Fungal Genet Biol. 48:840-8 18 55. Soares-Silva I, Sá-Pessoa J, Myrianthopoulos V, Mikros E, Casal M, Diallinas G. 2011. A substrate translocation trajectory in a cytoplasm-facing topological model of the 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. monocarboxylate/H⁺ symporter Jen1p. Mol Microbiol. 81(3):805-17 Amillis S, Kosti V, Pantazopoulou A, Mikros E, Diallinas G. 2011. Mutational analysis and modeling reveal functionally critical residues in transmembrane segments 1 and 3 of the UapA transporter. J Mol Biol. 411(3):567-80 Takeshita N, Diallinas G, Fischer R. 2012. The role of flotillin FloA and stomatin StoA in the maintenance of apical sterol-rich membrane domains and polarity in the filamentous fungus Aspergillus nidulans. Mol Microbiol. Mol Microbiol. 83(6):1136-52. Leung J, Cameron AD, Diallinas G, Byrne B. 2012. Stabilizing the heterologously expressed uric acid-xanthine transporter UapA from the lower eukaryote Aspergillus nidulans. Mol Membr Biol. 30(1):32-42. Kosti V, Lamprinidis G, Myrianthopoulos V, Diallinas G, Mikros E. 2012. Identification of a substrate recognition and transport pathway in a Eukaryotic Member of the NucleobaseAscorbate Transporter (NAT) Family. PLoS One. 7(7):e41939. Krypotou E, Kosti V, Amillis S, Myrianthopoulos V, Mikros E, Diallinas G. 2012. Modeling, Substrate Docking and Mutational Analysis Identify Residues essential for the function and specificity of a Eukaryotic Purine-Cytosine NCS1 Transporter. J Biol Chem. 287(44):36792803. Karachaliou M, Amillis S, Evangelinos M, Kokotos AC, Yalelis V, Diallinas G. 2013. The arrestin-like protein ArtA is essential for ubiquitination and endocytosis of the UapA transporter in response to both broad-range and specific signals. Mol Microbiol. 88(2):301-17 Diallinas, G. 2013. Allopurinol and xanthine use different translocation mechanisms and trajectories in the fungal UapA transporter. Biochimie 2013, Sep;95(9):1755-64 Krypotou E, Diallinas G. 2014. Transport assays in filamentous fungi: Kinetic characterization of the UapC purine transporter of Aspergillus nidulans. Fungal Genet Biol. Feb;63:1-8. doi: 10.1016/j.fgb.2013.12.004. Krypotou E, Lambrinidis G, Evangelidis T, Mikros E, Diallinas G. 2014. Modelling, substrate docking and mutational analysis identify residues essential for function and specificity of the major fungal purine transporter AzgA. Mol Microbiol Jul; 93(1):129-45. Galanopoulou K, Scazzocchio C, Galinou M, Borbolis F, Karachaliou M, Liu W, Oestreicher N, Hatzinikolaou D, Diallinas G, Amillis S. 2014. Purine utilization proteins in the Eurotiales: Cellular compartmentalization, phylogenetic conservation and divergence. Fungal Genet Biol. Aug; 69:96-108. Diallinas, G. 2014. Understanding transporter specificity and the discrete appearance of channel-like gating domains in transporters. Front. Pharmacol. 5:207. doi: 10.3389/fphar.2014.00207 Γημοζιεύζειρ ζε βιβλία-Μονογπαθίερ 67. B. Felenbok, V. Sophianopoulou, M. Mathieu, D. Sequeval, P. Kulmburg, G. Diallinas and C. Scazzocchio, 1989. Regulation of genes involved in the utilisation of carbon sources in Aspergillus nidulans. Procceedings of the EMBO-Alko Workshop on Molecular Biology of Filamentous Fungi, Helsinki 1989, ed. by Nevalainen and Pentilla. Foundation for Biotechnical and Industrial Fermentation Research, 6: 73-83. 68. Diallinas, G. Molecular Modeling of the Interactions of a Purine Transporter with Different Substrate Analogues: A first Step towards the Systematic Development of Antifungal Drugs. 2004 Review of Clinical Pharmacology and Pharmacokinetics, International Edition 18 (1), pp. 59. 69. Tavoularis, S.N., Tazebay, U., Diallinas, G., Scazzocchio, C., Sophianopoulou, V. Preliminary studies on structure-function analysis of a major proline transporter (PRNB) of the filamentous fungus Aspergillus nidulans. 1997 Amino Acids 13 (1), pp. 31. 19 70. G. Diallinas and A.K. Kanellis, 1995, Developmntal and ripening regulation of gene expression of phenylpropanoid biosynthetic enzymes in melon fruit. Post-harvest physiology, pathology and technologies for horticultural commodities: Recent Advances, 353-360, eds A.Ait-Oubahou abd El-Otmani. 71. G. Diallinas. 2007. Aspergillus transporters. In “The Aspergilli: Genomics, Medicine, Biotechnology and Research Methods", eds. G. Goldman and S. Osmani, CRC press. 20 Γημοζιεύζειρ-Ανακοινώζειρ ζε ζςνέδπια 1. G. Diallinas, V. Sophianopoulou and C. Scazzocchio. Cis-acting regulatory mutations defining target sites for regulatory gene products in Aspergillus nidulans (1989). Sardinia Symposium on Advances in Biotechnology and Control of gene expression, Alghero, Italy 2. G. Thireos, D. Alexandraki, G. Diallinas, G. Krupitza, E. Maniataki and D. Tzamarias. Translational regulation of GCN4 mRNA: in vivo and in vitro approaches (1990). NATO/EEC Workshop on Post-trnascriptional Control of Gene Expression, Goslar, West Germany 3. G. Thireos, D. Alexandraki, T. Georgakopoulos, G. Diallinas, G. Krupitza, E. Maniataki, I. Roussou, D. Tzamarias and N. Tzortzakis. Translational regulation of GCN4 mRNA and the control of protein synthetic rates in Yeast (1990). ICGEB Colloquium on Eucaryotic Gene Regulation and Expression, Crete 4. G. Diallinas and G. Thireos. Adaption of protein synthetic rates to amino acid availability in Saccharomyces cerevisiae (1991). 13th Meeting of the Hellenic Society of Biological Sciences, Heraklion, Crete, Greece 5. V. Sophianopoulou and G. Diallinas. AUA1, a gene involved in ammonia regulation of amino acid transport in Saccharomyces cerevisiae (1993). EMBO Workshop on Control of Gene Expression in Filamentous Fungi, Majorca, Spain 6. O. Moser, G. Diallinas and A. Kanellis. Purification, characterization and synthesis of ascorbate oxidase during melon fruit development (1993). 16th Scientific Conference of the Hellenic Scientific Society of Horticulture, Greece 7. Kanellis, G. Diallinas, P. Kalaitzis, G. Chronakis and K. Loulakakis. Differential induction of phenylalanine ammonia-lyase in response to ripening and wounding in muskmelon fruit (1993). Joint Annual Meeting of the American and Canadian Societies of Plant Physiologists. Supplement to Plant Physiol., 102: 61031 8. Kanellis and G. Diallinas. Development and Ripening Regulation of Gene Expression of phenylpropanoid Biosynthetic Enzymes in Melon fruit (1994). Proc. Int. Postharvest Symp., Post-harvest Physiology, Pathology and Technologies for horticultural commodities, Agadir, Moroco 9. G. Diallinas, I. Pateraki, O. Moser, I. Tsigos and A. Kanellis. Expression of ascorbic acid oxidase in response to development and wounding in melon (Cucumis melo) fruit (1994). 4th Int. Congress of Plant Mol. Biol., Amsterdam, Netherlands 10. Rosa, G. Diallinas, N. Prados Dodd, J. Valdez, V. Sophianopoulou and C. Scazzocchio. Aislamiento de mutantes del transportador especifico de prolina (PRNB) del hongo filamentoso A. nidulans (1994). 30th Reunion Annual SAIB, Misiones, Argentina 11. V. Sophianopoulou, U. H. Tazebay, C. Scazzocchio and G. Diallinas. Developmental and physiological regulation of the proline-specific transporter of the fungus A. nidulans (1995). Proceedings of the 17th Meeting of the Hellenic Society of Biological Sciences, Patras, Greece 12. G. Diallinas and C. Scazzocchio. Identification of regions and specific amino acid residues involved in purine transporter specificity and pH and temperature dependence in the fungus Aspergillus nidulans (1995). EMBO Annual Symposium on Protein Structure and Function, Heidelberg, Germany 13. V. Sophianopoulou, U. H. Tazebay, C. Scazzocchio and G. Diallinas. Post-transcriptional control and kinetic characterization of proline transport in germinated conidiospores of Aspergillus nidulans (1995). “Post-transcriptional Control of Eukaryotic Gene Expression”, International Summer School on Molecular and Cellular Biology, NATO-EMBO-FEMS. Spetses, Greece 14. Al Madhoon, G. Diallinas, M. Sanmartin, N. Panopoulos and A. Kanellis. Expression of ascorbic acid oxidase isoenzymes during development and ripening of fruit in melon (Cucumis melo) (1996). EU-Cost Action 915, Workshop “Consumer Perception and End Product Quality”, Feusisberg, Switzerland 15. G. Diallinas, V. Sophianopoulou, A. Kanellis, N. Panopoulos and C. Scazzocchio. Identification of regions and specific amino acid residues involved in purine transporter 21 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. specificity, pH and temperature dependence (1996). 45th Scientific Conference of the Hellenic Biochemical & Biophysical Society, Athens, Greece V. Sophianopoulou, U. H. Tazebay, C. Scazzocchio and G. Diallinas. Differential transcriptional activation of prnB, the gene encoding the major proline transporter of Aspergillus nidulans in response to proline induction and amino acid starvation (1996). 45th Scientific Conference of the Hellenic Biochemical & Biophysical Society, Athens, Greece G. Diallinas, I. Pateraki, M. Sanmartin, A. Al Madhoon, A. Scossa, N. Panopoulos and A. Kanellis. Expression and cloning of an ascorbate oxidase gene in melon (1996). 44th Scientific Conference of the Hellenic Biochemical & Biophysical Society, Athens, Greece Pateraki, G. Diallinas, M. Sanmartin, A. Scossa, M. Guis, J.P. Pech, N. Panopoulos and A. Kanellis. Evidence that ethylene represses ascorbate oxidase gene expression in melon (1996). "Biology and biotechnology of the plant hormone ethylene", NATO Advanced Research Workshop/European Union TMR Euroconference, Chania, Crete, Greece P. Ververidis, G. Diallinas, D. G. Georgakopoulos, N. Panopoulos and A. K. Kanellis. Έλα πξντφλ γνληδίνπ πνιιαπιήο αλζεθηηθφηεηαο ζε θάξκαθα εκπιέθεηαη ζηελ πξνζηαζία ηνπ απφ ηελ ηνμίλε θεξθνζπνξίλε (1996). 8ν Παλειιήλην Φπηνπαζνινγηθό Σπλέδξην, Ζξάθιεην, Κξήηε, Διιάο Ch. Vatsaki, I. Pateraki, G. Diallinas, A. Kanellis. Isolation and characterisation of an ACC synthase from melon (Cucumis melo L.) (1996).“Biology and biotechnology of the plant hormone ethylene”, NATO Advanced Research Workshop/European Union TMR Euroconference, Chania, Crete, Greece M. Guis, M. Sanmartin G. Diallinas, A. Latche, M. Bouzayen, A. Kanellis and J.P. Pech. Expression of phenylpropanoid biosynthetic genes in response to wounding in melon fruit harboring an antisense ACC oxidase gene (1996). "Biology and Biotechnology of the Plant Hormone Ethylene”, NATO Advanced Research Workshop/European Union TMR Euroconference, Chania, Crete, Greece V. Sophianopoulou, U. H. Tazebay, C. Scazzocchio and G. Diallinas. (1996). Differential transcriptional regulation of the major proline permease gene of Aspergillus nidulans in response to proline induction and amino acid starvation (1996). 24th Meeting of the Federation of European Biochemical Societies, Barcelona, Spain. G. Diallinas, V. Sophianopoulou, L. Gorfinkiel, G. Cecchetto, J. Valdez, A. Rosa and C. Scazzocchio. Structure-function analysis of purine transporters in Aspergillus nidulans (1996). SMYTE 14, Bonn, Germany P. Ververidis, G. Diallinas, D. G. Georgakopoulos, N. Panopoulos and A. K. Kanellis. A multidrug resistance gene product is involved in cercosporin detoxification in Saccharomyces cerevisiae (1996). NATO Advanced Research Workshop on “Regulation of Enzymatic Systems Detoxifying Xenobiotics in Plants”, Kallithea, Chalkidiki, Greece G. Diallinas, L. Gorfinkiel, A. Ravaganani, T. Langdon, D. Gorton, H. N. Arst. Jr., V. Sophianopolou and C. Scazzocchio (1997). DNA-binding specificity and functional synergy of transcriptional factors involved in regulation of expression of purine transporter genes in Aspergillus nidulans (1997). 45th Scientific Conference of the Hellenic Biochemical & Biophysical Society, Athens, Greece V. Sophianopoulou, U. H. Tazebay, C. Scazzocchio and G. Diallinas (1997). The expression of the gene encoding the major proline transporter in the fungus Aspergillus nidulans is activated during development and in response to amino acid starvation. 46th Scientific Conference of the Hellenic Biochemical & Biophysical Society, Athens, Greece S. N. Tavoularis, U. H. Tazebay, G. Diallinas, C. Scazzocchio and V. Sophianopoulou (1997). Mutational analysis addressing structure-function relationships in the major proline transporter (PrnB) of the filamentous fungus Aspergillus nidulans. 5th International Congress on Amino Acids, Chalkidiki, Greece Apostolaki, A. Rosa, U. H. Tazebay, G. Diallinas, C. Scazzocchio and V. Sophianopoulou (1997). Isolation of condititional mutants specific for the prnB gene encoding the major proline transporter in Aspergillus nidulans. Symposium of the Balkan Biological Society, Thessaloniki, Greece 22 29. J. Valdez, G. Diallinas, C. Scazzocchio and A. Rosa (1997). Purine transporters in Aspergillus nidulans. International Symposium on Nitrogen Metabolism of Ascomycetes, Hacienda Vista Hermosa, Mexico 30. G. Diallinas (1997). Regulation of expression and structure-function relationships of purine transporters in Aspergillus nidulans. International Symposium on Nitrogen Metabolism of Ascomycetes, Hacienda Vista Hermosa, Mexico 31. G. Diallinas, V. Sophianopoulou, J. Valdez and C. Scazzocchio, 1997. Chimeric protein analysis reveals a region involved in function and specificity of purine transporters in the filamentous fungusAspergillus nidulans conserved in bacteria, plants and metazoans. 48th Scientific Conference of the Hellenic Biochemical & Biophysical Society, Athens, Greece 32. P. Ververidis, F. Davrazou, G. Diallinas and N. Panopoulos, 1998. Genes and mechanisms for resistance to cercosporin in Saccharomyces cerevisiae. 49th Scientific Conference of the Hellenic Biochemical & Biophysical Society, Heraklion, Crete Greece 33. S. N. Tavoularis, G. Diallinas, C. Scazzocchio and V. Sophianopoulou 1998. Molecular characterisation of mutations leading to cryosensitivity of the proline transporter (PrnB) mRNA steady state levels in Aspergillus nidulans. 25th Silver Jubilee FEBS Meeting, Copenhagen, Denmark, P14.16 34. Goulas, V. Polymenakou, G. Diallinas, 1998. A domain critical for function and specificity of nucleobase transporters is conserved in bacteria, fungi, plants and metazoa. Proceedings of the 16th International Meeting SMYTE (FEMS), Casta-Papiernika, Slovakia, pp. 10-11 35. S. N. Tavoularis, U.H. Tazebay, G. Diallinas, C. Scazzocchio and V. Sophianopoulou 1998. Genetic, molecular and biochemical approaches to study structur-function relationships in the proline transporter of Aspergillus nidulans. Proceedings SMYTE 16, Casta-Papiernicka, Slovakia 36. S.N. Tavoularis, U.H. Tazebay, G. Diallinas, A. Rosa, C. Scazzocchio and V. Sophianopoulou, 1999. Mutational analysis of the proline transporter of Aspergillus nidulans shows non-random distribution of amino acid residues critical for function. Proceedings of the 17th International Meeting SMYTE, Cordoba, Spain, pp. 51-52 37. F. Davrazou, P. Ververidis, N. Panopoulos and G. Diallinas 1999 ABC multidrug transporters are involved in the detoxification of cercosporin and other photosensitizers in Saccharomyces cerevisiae. 2nd FEBS Advanced Lecture Course on "ATP-binding Cassette Transporters: From Multidrug Resistance to Genetic Disease", Austria 38. G. Diallinas, E. Argyrou and V. Sophianopoulou 1999. Use of a model microbial eukaryote for the functional analysis of maize and human nucleobase transporters. 50th Scientific Conference of the Hellenic Society of Biochemistryl & Molecular Biology Athens, Greece 39. S. Amillis and G. Diallinas. 1999. Physiological and developmental control of purinepyrimidine transporters in Aspergillus nidulans. 21st Panhellenic Congress of the Hellenic Society of Biological Sciences, Syros, Greece 40. E. Argyrou, C. Meintanis, N. Schultes, A.D. Karagouni, V. Sophianopoulou & G. Diallinas. 1999. Aspergillus nidulans as a model system to study nucleobase transporters: structurefunction relationships and expression of plant and human homologues. SMYTE 17, Cordoba, Spain, p. 50 41. S.N. Tavoularis, U.H. Tazebay, G. Diallinas, and V. Sophianopoulou, 1999. Amino acid residues Q219 and K245 of PrnB affect the kinetics of proline transport in Aspergillus nidulans. NATO-FEBS Summer School, Protein, lipid and membrane traffic: pathways and targeting, Cargese, Corsica 42. E. Argyrou, G. Diallinas, Qi Li, N. Schultes and V. Sophianopoulou, 2000. Functional characterization of Plant Nucleobase-Ascorbate Transporters. International Congress of Plant Molecular Biology, Quebec, Canada 43. V. Sophianopoulou, E. Argyrou, N. Schultes and G. Diallinas, 2000. Functional characterization of a maize purine transporter by expression in Aspergillus nidulans. Proceedings of the 18th International Meeting on Yeast Transport and Energetics (SMYTE), Ouro Preto, Brazil 44. G. Diallinas, S. Amillis and M. Koukakη, 2001. Suppression of cryosensitivity of mutation Q449E converts the uric acid-xanthine transporter of A. nidulans into a highly efficient 23 45. 46. 47. 48. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. transporter specific for nucleobases and nucleosides. Proceedings of the 18th International Meeting on Yeast Transport and Energetics (SMYTE), Ouro Preto, Brazil S. Amillis, M. Koukaki and G. Diallinas, 2000. Suppression of the Relaxed Specificity Mutation Q449E Converts the Uric-Acid-Xanthine Transporter of A. nidulans into a Highly Efficient General Purine Transporter. 22nd Panhellenic Congress of the Hellenic Society of Biological Sciences, Skiathos, Greece E. Argyrou, G. Diallinas, N. Schultes and V. Sophianopoulou, 2000. Functional Identification of a Plant Uric-Acid-Xanthine Transporter in the Model Fungus Aspergillus nidulans. 22nd Panhellenic Congress of the Hellenic Society of Biological Sciences, Skiathos, Greece G. Diallinas, 2000. Use of fungi as model systems to clone and functionally characterize transporters from protozoans, plants and animals. 5th European Conference on Fungal Genetics, Arcachon, France Γ. Γιαλλινάς, 2000. Υξήζε επθαξπσηηθψλ κηθξννξγαληζκψλ σο πξφηππσλ ζπζηεκάησλ κειέηεο λέσλ γνληδίσλ. Σν παξάδεηγκα ησλ δηακεκβξαληθψλ κεηαθνξέσλ λνπθιενηηδηθψλ βάζεσλ. Παλειιήλην Σπλέδξην ΠΔΒ. "Μνξηαθή Βηνινγία - Κπηηαξνγελεηηθή ζηελ Υγεία, Αζήλα E. Argyrou, G. Diallinas and V. Sophianopoulou, 2001. Aspergillus nidulans as a novel system for cloning and studying foreign nucleobase/ascorbate transporters. 27th FEBS Meeting, Lisbon, Portugal S. Amillis, M. Koukaki and G. Diallinas, 2001. Substitution F569S Converts UapA, a Specific Uric-Acid-Xanthine Transporter, into a Broad Specificity Transporter for PurineRelated Solutes. FEBS Summer School, Molecular dynamics of membrane biogenesis, Cargese, Corsica Qi Li, E. Argyrou, V. Sophianopoulou, G. Diallinas and N. Schultes, 2001. Characterization of Plant Nucleobase-Ascorbate Transporters. Annual Meeting of theAmerican Society of Plant Physiologists, USA S. Amillis, M. Koukaki and G. Diallinas, 2001. Substitution F569S Converts UapA, a Specific Uric-Acid-Xanthine Transporter, into a Broad Specificity Transporter for PurineRelated Solutes. 23rd Panhellenic Congress of the Hellenic Society of Biological Sciences, Chios, Greece E. Argyrou, Z. Erpapazoglou, A. Gioti, G. Diallinas and V. Sophianopoulou, 2001. Use of Aspergillus nidulans as a model system to study structure-function relationships of nucleobase-ascorbate transporters. 23rd Panhellenic Congress of the Hellenic Society of Biological Sciences, Chios, Greece G. Diallinas, 2001. Structure-function relationships in purine transporters of Aspergillus nidulans. 2nd International Symposium on Nitrogen Metabolism of Ascomycetes, Hacienda Vista Hermosa, Mexico M. Koukaki, S. Amillis and G. Diallinas, 2001. Genetic alteration of the specificity and kinetics of the uric acid-xanthine transporter in Aspergillus nidulans. Proceedings of the 19th International Meeting on Yeast Transport and Energetics (SMYTE), Chania, Greece G. Cecchetto, S. Amillis, C. Scazzocchio, G. Diallinas and C. Drevet, 2001. A Novel Purine Transporter is encoded by the azgA Gene of Aspergillus nidulans. Proceedings of the 19th International Meeting on Yeast Transport and Energetics (SMYTE), Chania, Greece E. Argyrou, G. Diallinas, L. Gorfinkiel, E. Holtzman and V. Sophianopoulou, 2001. Expression of plant and human nucleobase/ascorbate transporters in Aspergillus nidulans. Proceedings of the 19th International Meeting on Yeast Transport and Energetics (SMYTE), Chania, Greece S. Amillis, G. Cecchetto, C. Scazzocchio and G. Diallinas, 2001. Aspergillus nidulans purine transporters are differentially regulated in response to development, different nitrogen sources and the presence of purines. Proceedings of the 19th International Meeting on Yeast Transport and Energetics (SMYTE), Chania, Greece Γ. Γιαλλινάς θαη Β. νθηαλνπνχινπ, 2002. Μεηαθνξείο λνπθιενηηδηθψλ βάζεσλ ζηε κνξηαθή θαξκαθνινγία. 2ν Παλειιήλην Σπλέδξίν ηεο Διιεληθήο Δηαηξείαο Φαξκαθνινγίαο, Αζήλα, 9-10 Φεβξνπάξηνπ 24 61. . Γθνπληέια, Γ. Γιαλλινάς, 2002. Μεηαθνξείο πνπξηλψλ ηνπ παζνγφλνπ κχθεηα Candida albicans. 24o Παλειιήλην Σπλέδξην ΔΔΒΔ, Δξέηξηα Δχβνηαο 62. Γ. Εεξβνχ Γ. Γιαλλινάς, . Ρηδνπνχινπ, 2002. Μηα πνιπγνληδηαθε νηθνγέλεηα εμπαλζηλσλ ζηελ πεπνληά: ελδείμεηο γηα ην ξφιν ησλ εμπαλζηλσλ ζε αλαπηπζζφκελνπο ηζηνχο. 24o Παλειιήλην Σπλέδξην ΔΔΒΔ, Δξέηξηα Δχβνηαο 63. Γ. Παπαγεσξγίνπ Γ. Γιαλλινάς, Β. νθηαλνπνχινπ, Κ. σηεξηάδνπ, 2002. Βηνρεκηθφο ραξαθηεξηζκφο ηνπ κεηαθνξέα νπξαθίιεο ηνπ παζνγφλνπ πξσηφδσνπ Leishmania major. 24o Παλειιήλην Σπλέδξην ΔΔΒΔ, Δξέηξηα Δχβνηαο 64. Α. Παληαδνπνχινπ , Μ. Κνπθάθε , Γ. Γιαλλινάς, 2002. Γηεξεχλεζε ηνπ ξφινπ ηνπ πξψηνπ δηακεκβξαληθφ ηκήκαηνο ζηε ζηφρεπζε θαη ιεηηνπξγία ηνπ κεηαθνξέα ηνπ νπξηθνχ νμέσο UapA. 24o Παλειιήλην Σπλέδξην ΔΔΒΔ, Δξέηξηα Δχβνηαο 65. Μ. Κνπθάθε, Κ. Καγηάο, . Σνπξλαβίηε , Γ. Γιαλλινάς, 2002. Νεφηεξα δεδνκέλα ζηηο ζρέζεηο δνκήο-ιεηηνπξγίαο ζην κεηαθνξέα νπξηθνχ νμέσο UapA. 24o Παλειιήλην Σπλέδξην ΔΔΒΔ, Δξέηξηα Δχβνηαο 66. G. Diallinas and Μ. Κoukaki, 2002. Interactions of a purine transporter with different substrates. Proceedings of the 54th Scientific Conference of the Hellenic Society of Biochemistry & Molecular Biology, Ioannina, Greece 67. . Γθνπληέια & Γ. Γιαλλινάς. 2002. Υαξαθηεξηζκφο κεηαθνξέσλ πνπξηλψλ ηνπ παζνγφλνπ κχθεηα Candida albicans, Proceedings of the 54th Scientific Conference of the Hellenic Society of Biochemistry & Molecular Biology, Ioannina, Greece 68. Γ. Παπαγεσξγίνπ Γ. Γιαλλινάς, H. DeKoning, Κ. σηεξηάδνπ. 2002. Βηνρεκηθφο ραξαθηεξηζκφο ηνπ κεηαθνξέα νπξαθίιεο ζην παξαζηηηθφ πξσηφδσν L. major: Μνληέιν γηα ηελ αλαγλψξηζε ηνπ ππνζηξψκαηνο, Proceedings of the 54th Scientific Conference of the Hellenic Society of Biochemistry & Molecular Biology, Ioannina, Greece 69. M.Koukaki and G.Diallinas, 2003. A molecular model describing the interactions of a purine transporter with different substrates. Proceedings of the 25th Panhellenic Congress of the Hellenic Society of Biological Sciences, Mytilene, Greece 70. A.Pantazopoulou, A.Vlanti, M.Koukaki and G.Diallinas, 2003.On the mechanisms of purine transporter topogenesis in Aspergillus nidulans. Proceedings of the 25th Panhellenic Congress of the Hellenic Society of Biological Sciences, Mytilene, Greece 71. A. Pantazopoulou, M. Koukaki, A. Vlanti & G. Diallinas. (2003).Development of a model system to study the topogenesis of the nucleobase-ascorbate transporter family. 21st International Conference on Yeast Genetics & Molecular Biology, Gotheburg Sweden 72. M.Koukaki and G.Diallinas, 2003. A molecular model describing the interactions of a purine transporter with different substrates. 21st International Conference on Yeast Genetics & Molecular Biology, Gotheburg Sweden 73. G.Diallinas, 2004, Life without crystals or molecular genetic approaches to study structurefunction relationships in polytopic membrane proteins: The paradigm of the UapA uric acidxanthine transporter. Proceedings of the 56th Scientific Conference of the Hellenic Society of Biochemistry & Molecular Biology, Larissa, Greece 74. I. Soares-Silva, G. Diallinas and M. Casal. 2004. Functional study of a conserved domain between helixes 7 and 8 of the lactate permease Jen1p, from Saccharomyces cerevisiae.Yeast Genetics & Molecular Biology Meeting. Seattle, USA 75. N. D. Lemuh, A. Pantazopoulou, V.Varvarigos and G. Diallinas. 2005. Cellular expression of Uapa and AzgA, the two major purine transporters of Aspergillus nidulans. 27nd Panhellenic Conference of the Hellenic Society of Biological Sciences, Nafplio, Greece 76. H. Tsilivi, S. Goudela and G. Diallinas. 2005. Comparative kinetic analysis of AzgA in Aspergillus nidulans and Fcy2 in Candida albicans, prototypes of the two major fungal hypoxanthine-adenine-guanine transporter families. 27nd Panhellenic Conference of the Hellenic Society of Biological Sciences, Nafplio, Greece 77. K. Roumelioti, S. Amillis, Z. Hamari, C. Scazzocchio and G. Diallinas. 2005. Characterization of a new family of pyrimidine transporters in Aspergillus nidulans. 27nd Panhellenic Conference of the Hellenic Society of Biological Sciences, Nafplio, Greece 25 78. A.Vlanti, A.Pantazopoulou, S. Amillis, M.Koukaki, S. Goudela and G. Diallinas. 2005. Reconstructing the substrate translocation pathway in the Nucleobase Ascorbate Transporter (NAT) family using a model genetic system. Transports 2005 Workshop, Erice, Sicily, Italy 79. I.Soares-Silva, G. Diallinas, M. Casal . 2005 A conserved domain located between helices 7 and 8 of the Saccharomyces cerevisiae Jen1p is involved in substrate recognition. Proceedings of the 22th International Meeting on Yeast Transport and Energetics (SMYTE), New Delhi, India 80. D. Bouzarelou, G. Diallinas and V. Sophianopoulou, 2005. Cloning, molecular and functional characterization of an expansin-like protein in Aspergillus nidulans. Proceedings of the 57th Scientific Conference of the Hellenic Society of Biochemistry & Molecular Biology, Athens, Greece 81. A. Vlanti, S. Amillis, M. Koukaki, and G. Diallinas, 2005. The last transmembrane segment of UapA, a member of the nucleobase-ascorbate transporter (NAT) family, includes a substrate-selectivity filter and is necessary for ER-exit, Proceedings of the 57th Scientific Conference of the Hellenic Society of Biochemistry & Molecular Biology, Athens, Greece 82. S. Goudela, U. Reichard and G. Diallinas, 2006. Purine transporters as specific gateways for targeted pharmacological treatment of Aspergilli and Candida pathogens. 2nd Advances on Aspergillosis, Athens, Greece 83. A. Pantazopoulou and G. Diallinas, 2006. On the role of the first transmembrane segment of the UapA uric acid-xanthine transporter. 28th Panhellenic Conference of the Hellenic Society of Biological Sciences, Ioannina, Greece 84. C. Gournas, A. Vlanti, H. Pitsouli, S. Amillis, C. Delidakis and G. Diallinas, 2006. Expression of a Drosophila NAT homologue in A. nidulans. 28th Panhellenic Conference of the Hellenic Society of Biological Sciences, Ioannina, Greece 85. G.Langousis and G. Diallinas, 2006. On the dynamic topology of uric acid oxidase. 28th Panhellenic Conference of the Hellenic Society of Biological Sciences, Ioannina, Greece 86. E. Karakose, G. Serafimidis, U. Tazebay and G. Diallinas, 2006. Characterization of a novel mitosis-associated protein in a model fungal system. 28th Panhellenic Conference of the Hellenic Society of Biological Sciences, Ioannina, Greece 87. Y. Papageorgiou, K. Soteriadou and G. Diallinas, 2006. Genetic analysis of a Trypanosome purine transporter in S. cerevisiae. 28th Panhellenic Conference of the Hellenic Society of Biological Sciences, Ioannina, Greece 88. G. Diallinas , S. Amillis, A. Vlanti, S. Goudela, N. Lemuh, C. Gournas and A. Pantazopoulou. 2006 Purine transporters: cellular expression and transporter-substrate interactions. Proceedings of the 24th International Meeting on Yeast Transport and Energetics (SMYTE), Prague, Czech Republic 89. I. Papageorgiou, K. Soteriadou, H. De Koning and G. Diallinas, 2006. Genetic analysis of a trypanosome purine transporter in S. cerevisiae. Proceedings of the 24th International Meeting on Yeast Transport and Energetics (SMYTE), Prague, Czech Republic 90. I. Papageorgiou, H. De Koning, G. Diallinas and K. Soteriadou, 2006. Genetic analysis of a trypanosome purine transporter in S. cerevisiae.: a rational approach for targeted drug design. 3rd COST B22 ANNUAL CONGRESS “Drug discovery and development for parasitic diseases” Athens, October 2006 91. A. Vlanti, A. Pantazopoulou, S. Amillis, I. Papageorgiou, N. Dieudonne Lemuh, C. Gournas & G. Diallinas. 2007. Dissecting a purine transporter: intrinsic topogenetic signals, substrate binding and a selectivity filter. 32nd FEBS Congress Molecular Machines, Vienna, Austria 92. I. Papageorgiou, C. Gournas, A. Pantazopoulou, S. Amillis, A. Vlanti and G. Diallinas. 2007. Towards the past through genetic disruption of intramolecular synergism in the nucleobase-ascorbate transporter family. Proceedings of the 59th Scientific Conference of the Hellenic Society of Biochemistry & Molecular Biology, Athens, Greece 93. S. Gudin, I. Papageorgiou, G. Diallinas, K. Soteriadou, M.I. Al-Salabi1 and H.P. de Koning. 2008. Pyrimidine transport in Trypanosoma brucei and Leishmania major. BSP Trypanosomiasis/Leishmaniasis Seminar and Spring Meeting. Newcastle, UK. 94. I. Soares-Silva, Z.Foskolou, G. Diallinas and M. Casal. 2008. The Jen1p homologues in yeasts: a functional/structural approach on the transport of carboxylic acids across the plasma 26 membrane. Yeast Genetics and Molecular Biology Meeting sponsored by the Genetics Society of America. University of Toronto, Canada. 95. G. Diallinas. 2008. Structure-function relationships in the UapA uric acid (purine) transporter: Life before crystals. Horizons in Molecular Biology and Genetics, Ankara, Turkey. 96. C. Gournas, I. Papageorgiou, S. Amillis, A. Vlanti , V. Kosti, A.Pantazopoulou and G. Diallinas. 2008. A two-step mechanism for substrate selection, binding and transport of uric acid by a highly specific transporter. Channels and Transporters, Ettore Majorana Foundation and Center for Scientific Culture, Erice, Sicily, Italy. 97. Anasontzis G.E., Kourtoglou E., Mamma M., Amillis S., Christakopoulos P. , Diallinas G. , Karagouni A.D. and Hatzinikolaou D.G. 2008. Heterologous expression of aspergillus nidulans phosphoglucomutase in fusarium oxysporum. 30th Panhellenic Conference of the Hellenic Society of Biological Sciences, Thessaloniki, Greece 98. G. Diallinas, I. Papageorgiou, C. Gournas, A. Vlanti , V. Kosti, A.Pantazopoulou and S. Amillis, 2008. Intramolecular synergy as the basis for the evolution of a highly specific uric acid transporter. 26th Smyte (Small Meeting on Yeast Transport and Energetics), Braga, Portugal. 99. C. Gournas, S. Amillis, A. Vlanti and G. Diallinas. 2008. Regulationn of a uric acid transporter endopcytosis. 26th Smyte (Small Meeting on Yeast Transport and Energetics), Braga, Portugal. 100. P.C. Borbolis, C. Gournas, M. Karachaliou, D. Hatzinicolaou, A. Pantazopoulou, and G. Diallinas. 2008. A cryptic role of uric acid metabolism and intercellular transport in fungal development reveals analogies with metazoa. 26th Smyte (Small Meeting on Yeast Transport and Energetics), Braga, Portugal. 101. G. Diallinas. (2008). Genetic dissection of a purine transporter or how UapA specificity is determined. Final Eurofungbase Meeting, LSSG-CT-2005-018964, San Feliu de Guixols, Spain 102. S. Amillis, A. Vlanti, C. Gournas, and G. Diallinas. (2008). Substrate- and ammonium induced endocytosis down-regulate the UapA purine transporter through ubiquitination. Final Eurofungbase Meeting, LSSG-CT-2005-018964, San Feliu de Guixols, Spain 103. F. Borbolis, M. Karachaliou, C. Gournas, D. Hatzinikolaou, A. Pantazopoulou, and G. Diallinas. (2008). A cryptic role of uric acid metabolism and intercellular redistribution in Aspergillus nidulans development. Final Eurofungbase Meeting, LSSG-CT-2005-018964, San Feliu de Guixols, Spain 104. I. Soares-Silva, Z. Foskolou, G. Diallinas, M. Casal. (2009) Identification of a new domain of the lactate/pyruvate:H+ symporter subfamily critical for distinguishing mono- and dicarboxylate permeases. 24th International Conference on Yeast Genetics & Molecular Biology, Manchester, UK 105. A. Pavlides, S. Amillis, V. Paspaliaris, G. Diallinas. C. Gournas. 2009. Mediators of transporter endocytosis in A. nidulans: the protagonist role of hulA ubiquitin ligase. 31th Panhellenic Conference of the Hellenic Society of Biological Sciences, Patras, Greece 106. GE. Anasontzis, PM. Stathopoulou, S. Amilis, AD. Karagouni, G. Diallinas, DG. Hatzinikolaou. 2009. Homologous overexpression of phosphoglucomutase and transaldolase in Fusarium oxysporum. European Congress on Biotechnology (ECB-14), Barcelona, Spain 107. C. Gournas, S. Amillis, A. Vlanti, G. Diallinas 2009. Transport-dependent turnover of a uric acid-xanthine permease occurs via a novel endocytic mechanism. Proceedings of the 60th Scientific Conference of the Hellenic Society of Biochemistry & Molecular Biology, Athens, Greece 108. G. Diallinas (2009) Structure-function relationships and mechanisms of protein trafficking in A. nidulans transporters. Eurofungbase Meeting, Wagenigen, Holland. 109. V. Bitsikas, M. Karachaliou, C. Gournas, A. Pavlides, G. Diallinas (2010) Hypertonic conditions trigger transient plasmolyis, growth arrest and blocjkage of endocytosis in Aspergillus nidulans and Saccharomyces cerevisiae. 32th Panhellenic Conference of the Hellenic Society of Biological Sciences, Karpenisi, Greece 27 110. M. Karachaliou, J. Leung, C. Alves, B. Byrne, G. Diallinas (2010) Expression & Purification of a functional uric acid-xanthine transporter (UapA) 32th Panhellenic Conference of the Hellenic Society of Biological Sciences, Karpenisi, Greece 111. M. Karachaliou, V. Bitsikas, C. Gournas, A. Pavlides, G. Diallinas (2010) Hypertonic conditions trigger transient plasmolyis, growth arrest and blockage of endocytosis in Aspergillus nidulans and Saccharomyces cerevisiae. 9th International Mycological Congress (IMC9: the Biology of Fungi), Edinburgh, Scotland. 112. Talaia, G., Diallinas, G., Casal, M., Paiva, S. 2011. Pinpointing intracelllar trafficking determinants in the Jen1 yeast lactate transporter by domain swap. MicroBiotec11 Congress, 1-3 December 2011, Braga, Portugal. 113. S. Amillis, V. Kosti, M. Karachaliou, V. Giallelis & G. Diallinas 2011. Signals and mechanisms of transporter endocytosis in a model fungal system. EMBO Conference Series, Dynamic Endosomes: Mechanisms Controlling Endocytosis. 24-29th September 2011, Chania, Greece 114. V. Τialelis, G. Diallinas & S. Amillis 2011. The amino terminal region of the uric/xanthine permease UapA contains regulatory motif for its sub-cellular trafficking and function. 4th Hellenic Society Mikrobiokosmos Congress, 21-23rd October 2011, Ioannina, Greece 115. A. Krypotou, V. Kosti, S. Amillis, E. Mikros, V. Myrianthopoulos, G. Diallinas 2011. Structure-function relationships in the cytosine-purine transporter FcyB through rational mutational analysis and structural modelling. 4th Hellenic Society Mikrobiokosmos Congress, 21-23rd October 2011, Ioannina, Greece 116. A. Krypotou, V. Kosti, V. Myrianthopoulos, E. Mikros, S. Amillis, G. Diallinas 2011. A combined computational and genetic approach for studying structure-function relationships in the cytosine-purine transporter FcyB Proceedings of the 62th Scientific Conference of the Hellenic Society of Biochemistry & Molecular Biology, Athens, Greece 117. Amillis S., Karachaliou M., Kosti V., Giallelis V., Vlanti A., Gournas C., & Diallinas G. 2011. Signals and mechanisms of membrane cargo trafficking and endocytosis in a model fungal system. Proceedings of the 62th Scientific Conference of the Hellenic Society of Biochemistry & Molecular Biology, Athens, Greece 118. J.S. Pessoa, I.Soares Silva, V. Myrianthopoulos, E. Mikros, G.Diallinas, M. Casal. 2011. Identification of amino acid residues critical for the substrate translocation in lactate permease Jen1p of Saccharomyces cerevisiae. 55th Annual Meeting of the Biophysical Society, Baltimore Convention Center, Baltimore, Maryland, USA. 119. J.S. Pessoa, S. Viegas, G. Rocha, G. Diallinas, S. Paiva, C. Arraiano, M. Casal. 2011. Discovery and initial characterization of members of the new YaaH family of microbial acetate transporters. 55th Annual Meeting of the Biophysical Society, Baltimore Convention Center, Baltimore, Maryland, USA. 120. Kokotos AC, Evangelinos M, Diallinas G. 2012. Transporter down-regulation in a model fungal system: Cross-talk of cargo ubiquitination with initiation of endocytosis. 32nd European Peptide Symposium, Athens, Greece 121. G. Diallinas, E. Mikros & B. Byrne. 2012. Structure-function-specificity relationships in a eukaryotic purine transporter: From genetics to molecular topology. 3rd International Workshop on Expression, Structure and Function of Membrane Proteins, Florence, Italy 122. E. Krypotou, V. Kosti, S. Amillis, E. Mikros, B. Byrne and G. Diallinas. 2012. Towards the elucidation of structure-function relationships at the molecular level of two prototypic nucleobase transporters in Aspergillus nidulans. Eurofung meeting, Berlin, Germany. 123. G. Diallinas. 2012. FEBS Special Meeting, Protein Quality Control and Ubiquitin Systems in health and disease, Kusadasi, Turkey. 124. Karachaliou M., Amillis S. and Diallinas G. 2012. Mechanisms of ubiquitination and endocytic internalization of a transporter cargo in a model fungal system. FEBS Special Meeting, Protein Quality Control and Ubiquitin Systems in health and disease, Kusadasi, Turkey. 125. Kosti V. & Diallinas G. 2012. A novel AP3-dependent vacuolar degradation pathway for intrinsically unstable mutants of the UapA transporter: evidence for Golgi control for 28 unfolded proteins. Proceedings of the 63th Scientific Conference of the Hellenic Society of Biochemistry & Molecular Biology, Iraklio, Crete, Greece 126. Krypotou E., Kosti V., Amillis S., Myrianthopoulos V., Mikros E., Diallinas G. 2012. Modeling, substrate docking and mutational analysis identify residues essential for the function and specificity of the purine-cytosine transporter FcyB. . Proceedings of the 63th Scientific Conference of the Hellenic Society of Biochemistry & Molecular Biology, Iraklio, Crete, Greece 127. G. Diallinas. 2013. The arrestin-like protein ArtA is essential for ubiquitination & endocytosis of the UapA transporter in response to both broad-range & specific signals. 27th Fungal Genetics Conference, Asilomar Conference Grounds, Pacific Grove, California USA 128. K. Galanopoulou, M.Galinou, F. Borbolis, M. Karachaliou, S. Amillis, & G. Diallinas. 2013. Subcellular localization of key proteins involved in purine catabolism: functional implications and cryptic roles. 34th Panhellenic Conference of the Hellenic Society of Biological Sciences, Nafplio, Greece. 129. M. Evangelinos, M. Karachaliou, A. C. Kokotos, V. Yalelis, S. Amillis & G. Diallinas. 2013. The arrestin-like protein ArtA is essential for ubiquitination and endocytosis of the UapA transporter in response to both broad-range and specific signals. 34th Panhellenic Conference of the Hellenic Society of Biological Sciences, Nafplio, Greece. 130. M. Karachaliou and G. Diallinas. FEBS-EMBO Advanced Lecture Course, Biomembranes: Molecular Architecture, Dynamics and Function, Cargese, Corsica, France, June 10-20, 2013. 131. M. Evangelinos, V. Kosti, S. Amillis and G. Diallinas. Turnover of misfolded purine transport moleculaes via a novel ubiquitin-dependent quality control mechanism. 31st SMYTE meeting (Small Meeting on Yeast Transport and Energetics) Antalya, Turkey, September 24 - 28, 2013. 132. G. Diallinas. Distinct mecahnisms control ubiquitination and turnover of the UapA transporter in response to physiological signals or protein misfolding. 31st SMYTE meeting (Small Meeting on Yeast Transport and Energetics) Antalya, Turkey, September 24 - 28, 2013. 133. G. Diallinas. Regulation of Transporter endocytosis and turnover: Lessons from a simple fungal system. 2nd International Congress of the Molecular Society of Turkey (EMBO sponsored), 22-23 November 2013. 134. E. Krypotou, G. Lambrinides, T. Evangelidis, E. Mikros & G. Diallinas. Modeling, substrate docking and mutational analysis identify residues essential for function and specificity of a major fungal purine transporter. Proceedings of the 64th Scientific Conference of the Hellenic Society of Biochemistry & Molecular Biology, Athens, Greece. 6-8 December 2013. 135. M. Evangelinos, S. Amillis, M. Karachaliou & G. Diallinas. Transporter sorting and endocytosis: lessons from a model fungus. Proceedings of the 64th Scientific Conference of the Hellenic Society of Biochemistry & Molecular Biology, Athens, Greece. 6-8 December 2013. 136. Karachaliou M., Amillis S., Yalelis V. & Diallinas G. Role of oligomerization in the trafficking and vacuolar turnover of a purine transporter in a model fungal system EMBO Workshop: Signalling to and from endomembranes, Allensbach-Hegne, Germany, 15-19 March 2014. 137. G. Diallinas. How transporter specificity is determined: an emerging role of channel-like gating domains (lessons from Aspergillus nidulans. ECFG12-Seville, Spain, 23-27 March 2014. 138. M. Evangelinos & G. Diallinas. A novel ER/Golgi-resident mechanism controls vacuolar turnover of partially misfolded transporters. ECFG12-Seville, Spain, 23-27 March 2014. 139. E. Krypotou, G. Lamprinidis, T. Evangelidis, E. Mikros, C. Scazzocchio & G. Diallinas. Cryptic functions and evolution of substrate specificities in the Fur-like transporter family in Aspergillus nidulans. ECFG12-Seville, Spain, 23-27 March 2014. 140. M. Evangelinos, S. Amillis, I. Rousounelou & G. Diallinas. Specific partially misfolded versions of the UapA transporter are turned-over by ubiquitination-dependent selective 29 autophagy. 1st PROTEOSTASIS Meeting, Cost proteostasis action bm1307, Valencia, Spain, 4-7 November 2014 141. O. Martzoukou, M. Karachaliou, M. Evangelinos, S. Amillis, & G. Diallinas. The role of transmembrane cargo oligomerization in ER-exit and membrane organization. 1st PROTEOSTASIS Meeting, Cost proteostasis action bm1307, Valencia, Spain, 4-7 November 2014
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