Friday, September 12, 2014

Friday, September 12, 2014
08.00-19.00
Registration / Information Desk Open
Session I
BASIC ASPECTS OF IRON BIOLOGY
Chairs: Raffaella Gozzelino (Lisbon, Portugal) and Robert Hider (London, UK)
08.30 I01
LECTURE
Iron and Gut Microbiota
Eric Oswald (Toulouse, France)
09.00 T01 Cellular Ferritin Trafficking, Polarization and Secretion
Marianna Truman-Rosentsvit, Adi Bukris, Esther G. Meyron-Holtz (Haifa, Israel)
09.15 T02 The inhibitory role of iron in osteogenic differentiation and osteoblast function
Viktória Jeney, Enikő Balogh, Zarjou Abolfazl, Paolo Arosio, György Balla, József Balla
(Debrecen, Hungary; Alabama, USA; Brescia, Italy)
09.30 T03
Profilin2 is controlled by the Iron Regulatory Proteins and modulates iron homeostasis
Sara Luscieti, Pietro Pilo Boyl, Bruno Galy, Lucía Gutiérrez, Maya Shvartsman,
M. Puerto Morales, Matthias W. Hentze, Walter Witke, Mayka Sanchez
(Badalona, Spain; Bonn, Heidelberg, Germany; Madrid, Spain)
09.45 T04 Regulation of Cardiac Iron Homeostasis Offers a Novel Paradigm for Ferroportin and
Hepcidin Functions at the Single Tissue Level
Samira Lakhal-Littleton, Magda Wolna, Ben Davies, Damian Tyler, Carolyn Carr,
Vicky Ball, Kieran Clarke, Peter Robbins (Oxford, UK)
10.00 T05 Quick transformation of magnetic nanoparticles for biomedical applications into ferritin in a rat model
Lucía Gutiérrez, Amalia Ruiz, Paolín R. Cáceres, Djalma Santos, Sacha B. Chaves,
Maria Luisa Fascineli, Mónica P. Garcia, Ricardo B. Azevedo, Puerto Morales
(Madrid, Spain; La Habana, Cuba; Brasilia, Brasil)
10.15 Coffee Break
Session II
IRON AND OXIDATIVE STRESS/NEOPLASTIC DISEASES
Chairs: Mayka Sanchez (Barcelona, Spain) and Gaetano Cairo (Milan, Italy)
10.45 I02
LECTURE
Iron and cancer
Frank Torti (Connecticut, USA)
11.15 T06 Iron content and Ferroportin in the breast tissue of obese and non-obese postmenopausal Caucasian women with and without Breast Cancer
Agarwal Puja, Kent Hoskins , Elizabeta Nemeth, Gamilla Fantuzzi, Sally Freels,
Andre Kajdacsy-Balla , Robert J. Cabay, Andy Hall, Carol Braunschweig
(Chicago, Los Angeles, USA)
11.30 T07 Disrupting iron homeostasis of multiple myeloma: a novel strategy of potential
therapeutic value
Alessandro Campanella, Jessica Bordini, Maurizio Ponzoni, Sabrina Bertilaccio,
Giovanni Tonon, Clara Camaschella (Milan, Italy)
11.45 T08 Iron levels define two populations of Tumor Associated Macrophages
Milene Costa da Silva, Francesca Vinchi, Adelheid Cerwenka, Martina U. Muckenthaler
(Heidelberg, Germany)
12.00 T09 A novel generation of photoactivatable caged-iron chelators with both antioxidant
and iron chelation properties for skin photoprotection
Olivier Reelfs, Benjamin Young, Tina Radka, Asma Aroun, Ian M. Eggleston, Charareh Pourzand (Bath, UK)
12.15 T10
TFR2β null mice have an increase cardiac ischemia/reperfusion tolerance
Martina Boero, Francesca Tullio, Rosa Maria Pellegrino, Antonietta Palmieri,
Ludovica Ferbo, Pasquale Pagliaro, Giuseppe Saglio, Marco De Gobbi, Claudia Penna, Antonella Roetto (Turin, Italy)
12.30 Lunch & Poster Session I (P01-P61)
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Session III
IRON, HEME, AND ERYTHROPOIESIS
Chairs: Martina Muckenthaler (Heildeberg, Germany) and Clara Camaschella (Milan, Italy)
14.30 I03
LECTURE
Intersection between iron and glucose homeostasis
Antonello Pietrangelo (Modena, Italy)
15.00 T11 The role of the second transferrin receptor in erythropoiesis
Antonella Nai, Maria Rosa Lidonnici, Marco Rausa, Giacomo Mandelli, Alessia Pagani,
Laura Silvestri, Giuliana Ferrari, Clara Camaschella (Milan, Italy)
15.15 T12 Effects of green tea extract and iron chelators on hepcidin expression in β- thalassemic mice
Supranee Upanan, Kanjana Pangjit, Chairat Uthaipibull, Suthat Fucharoen, Andrew T. McKie,
Somdet Srichairatanakool (Chiang Mai, Ubon Ratchathani, Pathumthani,Nakornpathom,
Thailand; London, UK)
15.30 T13 Erythropoietin administration increases liver matriptase-2 protein content in rats and mice
Jan Krijt, Jana Frýdlová, Petr Prikryl, Iuliia Gurieva, Jaroslav Truksa, Martin Vokurka
(Prague, Czech Republic)
15.45 T14 An adaptive mechanism for erythrocyte disposal and iron recycling in the liver
Igor Theurl, Ingo Hilgendorf, Malte Asshoff, Milan Theurl, Louisa M. S. Gerhardt,
Tobias A. W. Holderried, Markus Seifert, Sieghart Sopper, Georg F. Weber,
Tara L. Avedson, Mary McKee, Jodie L. Babitt, Matthias Nahrendorf, Guenter Weiss,
Ralph Weissleder, Herbert Y. Lin, Filip K. Swirski (Boston, Thousand Oaks, USA;
Innsbruck, Austria; Duesseldorf, Germany)
16.00 T15 Endothelial loss of the heme exporter FLVCR1a alters vascular integrity
Sara Petrillo, Sonia Mercurio, Francesca Vinchi, Deborah Chiabrando, Lorenzo Silengo, Massimo Santoro, Fiorella Altruda, Emanuela Tolosano (Turin, Italy; Heidelberg, Germany)
16.15 Coffee Break
Session IV
IRON AND NEURODEGENERATION
Chairs: Ioav Cabantchik (Jerusalem, Israel) and Paolo Arosio (Brescia, Italy)
16.45 I04
LECTURE
Disorders of Neurosiderosis: causes and possible treatment
Ioav Cabantchik (Jerusalem, Israel)
17.15 T16 Brain iron chelation by deferiprone in Parkinson’s disease patients
David Dexter, Roberta Ward, Antonio Martin-Bastida, Paola Piccini, David Sharp,
Rexfordì Newbould, Michaelì Spino, John Connelly, Tricta Fernando, Robert Crichton,
(London, UK; Toronto, Canada; Louvain-la-Neuve, Belgium)
17.30 T17 Iron Chelating treatment in Neurodegeneration with Brain Iron Accumulation
Nardo Nardocci (Milan, Italy)
17.45 T18 Mitochondrial functionality and oxidative status are affected in fibroblasts and induced
neurons from Pantothenate Kinase Associated Neurodegeneration patients
Sonia Levi, Michela Guaraldo, Anna Cozzi, Sabrina Dusi, Paola Venco, Valeria Tiranti,
Vania Broccoli, Paolo Santambrogio (Milan, Italy)
18.00 T19 Understanding iron sulfur cluster biogenesis and its relationship to human health
Rita Puglisi, Salvatore Adinolfi, Annalisa Pastore, (London, UK)
18.15 T20 TFR2 KO mice show brain iron overload with microglia alterations and anxious behavior
Rosa Maria Pellegrino, F. Montarolo, E. Boda, A. Palmieri, M.R. Mezzanotte, M. Boero,
G. Saglio, A. Buffo, A. Roetto (Turin, Italy)
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Saturday, September 13, 2014
08.00-17.00
Registration / Information Desk Open
Session V
IRON DEFICIENCY, PATHOPHYSIOLOGY, DIAGNOSIS, AND TREATMENT
Chairs: Dorine W. Swinkels (Nijmegen, The Netherlands) and Maria Domenica Cappellini (Milan, Italy)
09.00 I05
LECTURE
Exploiting plant science to reduce nutritional iron deficiency
Irene Murgia (Milan, Italy)
09.30 T21 The effects of iron supplementation on plasma fibroblast growth factor-23
in West African children
Vickie Braithwaite, Andrew M. Prentice, Conor Doherty, Ann Prentice
(Cambridge, UK; London UK; Keneba, The Gambia)
09.45 T22 Stable iron isotopic techniques and plasma hepcidin profiles to optimize iron supplementation
regimens for correction of iron deficiency in young women
Diego Moretti, Jeroen S. Goede, Markus Jiskra, Alida Melse, Harold Tjalsma, Dorine W. Swinkels,
Gary Brittenham, Michael B. Zimmerman (Zürich, Switzerland; Wageningen, Nijmegen, the
Netherlands; New York, USA)
10.00 T23 Genotype-phenotype studies in 70 IRIDA patients
De Falco Luigia, Laura Silvestri, Caroline Kannengiesser, Erica Moran, Claire Oudin,
Marco Rausa, Mariasole Bruno, Jessica Aranda, Bienvenida Argiles, Idil Yenicesu,
Maria Falcon-Rodriguez, Ebru Yilmaz-Keskin, Ulker Kocak, Carole Beaumont,
Clara Camaschella, Bernard Grandchamp, Mayka Sanchez, Achille Iolascon
(Naples, Milan, Italy; Paris, France; Badalona, Barcelona, Las Palmas de Gran Canarias,
Valencia, Spain; Ankara, Turkey)
10.15 T24 Iron deficiency impairs regulatory T cell induction
Richard Danger, Eliano Riani, Elisavet Kodela, Robert Hider, Marc Martínez-Llordella,
Alberto Sánchez-Fueyo (London, UK)
10.30 T25 Transferrin receptor 2 is shed from plasma membrane in iron deficiency
Alessia Pagani, Maud Vieillevoye, Antonella Nai, Marco Rausa, Meriem Ladli, Catherine Lacombe,
Patrick Mayeux, Frédérique Verdier, Laura Silvestri, Clara Camaschella
(Milan, Italy; Paris, France)
10.45 Coffee Break
Session VI
IRON IN INFLAMMATORY, INFECTIOUS, METABOLIC DISEASES
Chairs: Guenter Weiss (Innsbruck, Austria) and Alexander Drakesmith (Oxford, UK)
11.15 I06
LECTURE
Iron nutrition in the tropics: interactions with malaria, diarrhea the gut microbiome
Michael Zimmerman (Zurich, Switzerland)
11.45 T26 Iron and hepcidin independent regulation of the iron exporter ferroportin in macrophages
during Salmonella infection
François Canonne-Hergaux, Sean Beatty, Anne Auriac, Alexandra Willemetz, Sophie Vaulont,
Danielle Malo (Toulouse, France; Montréal, Québec, Canada)
12.00 T27 Interleukin-6 is dispensable for hepcidin induction by Escherichia coli and
Staphylococcus aureus
Aurélie Gineste, Céline Besson-Fournier, Chloé Latour, Patricia Martin, Eric Oswald,
Hélène Coppin, Marie-Paule Roth (Toulouse, France)
12.15 T28 Gut microbial metabolism shifts towards a more toxic profile with supplementary iron in
a kinetic model of the human large intestine
Guus Kortman, Bas Dutilh, Annet Maathuis, Udo Engelke, Jos Boekhorst, Kevin Keegan,
Fiona Nielsen, Leo Kluijtmans, Dorine Swinkels, Koen Venema, Harold Tjalsma (Nijmegen,
Zeist, Ede, The Netherlands; Argonne, IL, USA; Essex, UK)
12.30 T29 Hemopexin controls macrophage polarization by reverting heme-induced differentiation towards an M1 pro-inflammatory phenotype
Francesca Vinchi, Milene Costa da Silva, Giada Ingoglia, Sara Petrillo, Emanuela Tolosano,
Martina U. Muckenthaler (Heidelberg, Germany; Turin, Italy)
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12.45 T30
13.00
High Transferrin Saturation is Independently Associated with Poor Survival in Acute on
Chronic Liver Failure
Livia Dorn, Armin Finkenstedt, Igor Theurl, Thomas Wagner, Vogel Wolfgang, Heinz Zoller
(Innsbruck, Austria)
Lunch & Poster Session II (P62-P120)
Session VII
NEXT GENERATION SEQUENCING IN GENETIC DISORDERS
OF IRON METABOLISM
Chairs: Nathan Subramaniam (Brisbane, Australia) and Domenico Girelli (Verona, Italy)
15.00 I07
LECTURE
Interpreting Next Generation Sequencing data in the clinic
Massimo Delledonne (Verona, Italy)
15.30 T31 A Novel Next-Generation Sequencing Platform for the Identification of Genetic Variants:
Application to the Diagnosis of Non-HFE Haemochromatosis
Nathan Subramaniam, Daniel Wallace, Cameron McDonald (Brisbane, Australia)
15.45 T32 A common variant in the SLC11A2 gene alters hepcidin concentrations and iron status in
African children
Sarah Helen Atkinson, A. Macharia, Shivani Khandwala, Andrew E. Armitage, Sophie M. Uyoga,
P. Bignall, A. Schuh, D. Kwiatkowski, K. Rockett, Andrew M. Prentice, Hal Drakesmith,
Thomas N. Williams (Oxford, London, UK; Kilifi, Kenya)
16.00 T33 The uncovering of a syndromic type of sideroblastic anaemia with Immunodeficiency,
periodic fevers and developmental delay (SIFD)
Alison May, P.K. Chakraborty, K. Schmitz-Abe,E.K. Kennedy, K. Mamady, T. Naas,
D. Durie, D.R. Campagna,A. Lau,A.K. Sendamarai,D.H. Wiseman, S. Jolles, P. Connor,
C. Powell et. al. (Cardiff, Bristol, Manchester, UK; Ottawa, Montreal, Toronto, Canada;
Bethesda, Boston, Chicago, New York, USA; Paris, Marseilles, France; Porto, Potugal)
16.15 T34 Targeted Next Generation Sequencing of the Five Hemochromatosis Genes in Italian patients with iron overload and non-diagnostic first level genetic test: a pilot study
Sadaf Badar, Fabiana Busti, Giampiero Zamperin, Alberto Ferrarini, Paolo Bozzini,
Daniele Manna, Natascia Campostrini, Giovanna De Matteis, Massimo Delledonne,
Domenico Girelli (Verona, Italy)
16.30 T35 A meta-analysis of genome-wide association studies for serum hepcidin
Tessel Galesloot, Niek Verweij, Michela Traglia, Lambertus Kiemeney, Peter van der Meer,
Clara Camaschella, Daniela Toniolo, Sita Vermeulen, Pim van der Harst, Dorine Swinkels
(Nijmegen, Utrecht, Groningen, The Netherlands; Milan, Trieste, Pavia Italy)
20.00 Social Dinner at Hotel Due Torri
24.00
Sunday, September 14, 2014
08.00-13.30
Registration / Information Desk Open
Session VIII
THE HEPCIDIN-FERROPORTIN AXIS/HEPCIDIN MODULATORS
Chairs: Tomas Ganz (Los Angeles, USA) and Laura Silvestri (Milan, Italy)
08.30 I08
LECTURE
Hepcidin Pharmacology
Elizabeta Nemeth (Los Angeles, USA)
09.00 T36 Non anticoagulant heparins for the inhibition of hepcidin in vitro and in vivo
Maura Poli, Michela Asperti, Annamaria Naggi, Margherita di Somma, Paola Ruzzenenti,
Natascia Campostrin, Magdalena Gryzik, Domenico Girelli, Paolo Arosio
(Brescia, Milan, Verona, Italy)
09.15 T37 Clinical Pharmacology, Efficacy, and Safety of the Anti-Hepcidin Spiegelmer Lexaptepid Pegol
Kai Riecke, Ludwig Heinz, Lucas van Eijk, Malcolm Boyce, Peter Pickkers, Iain Macdougall,
Frank Schwöbel, Dorine Swinkels (Berlin, Germany; Vienna, Austria; Nijmegen, The Netherlands;
London, UK)
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09.30 T38 Bmp6 and Hfe additively regulate hepcidin production by signaling pathways that converge on
Smad1/5/8 phosphorylation
Chloé Latour, Céline Besson-Fournier, Ophélie Gourbeyre, Patricia Aguilar-Martinez,
Marie-Paule Roth, Hélène Coppin (Toulouse, France)
09.45 T39 The Role of Jak2 in Hepcidin-dependent Ferroportin Internalisation in Macrophages
Malte Asshoff, Verena Petzer, Markus Seifert, David Haschka, Egon Demetz, Manfred Nairz,
Kay-Uwe Wagner, Günter Weiss, Igor Theurl (Innsbruck, Austria; Omaha, USA)
10.00 T40 Hepcidin-25 assays and sensors based on molecularly imprinted nanoparticles
Alessandra Maria Bossi, Erika Andreetto; Lucia Cenci, Annalisa Castagna; Domenico Girelli;
Oliviero Olivieri (Verona, Italy)
10.15 Coffee Break
Session IX
IRON OVERLOAD, PATHOPHYSIOLOGY, DIAGNOSIS, AND TREATMENT
Chairs: Olivier Loreal (Rennes, France) and Antonello Pietrangelo (Modena, Italy)
10.45 I09
LECTURE
HFE genotypes in elite athletes
Jean-Francoise Toussaint (Paris, France)
11.15 T41 Second International Round Robin for the quantification of non-transferrin-bound iron
and labile plasma iron in patients with iron overload disorders
Louise de Swart, Jan C.M. Hendriks, Lisa van der Vorm, Z. Ioav Cabantchik, Patricia J. Evans,
Eldad Hod, Gary M. Brittenham, Yael Furman, Mirian C.H. Janssen, Bart J. Biemond,
Marius A. MacKenzie, Vera E.J.M. Mattijssen, Raffaella Origa, Renzo Galanello,
Robert C. Hider, Dorine W. Swinkels
(Nijmegen, Amsterdam, Arnhem The Netherlands; Jerusalem, Tel-Aviv, Israel; London, UK;
New York, USA)
11.30 T42
Toward a reliable 3D structure of the iron exporter ferroportin: a combined theoretical
and experimental approach
Isabelle Callebaut, Chandran Ka, Rozenn Joubrel, Chandran Ka, Isabelle Gourlaouen,
Pierre Lehn, Jean-Paul Mornon, Claude Férec, Gérald Le Gac (Brest, Paris, France)
11.45 T43 Insulin signaling in primary hepatocytes from wild-type and hepcidin knock-out mice
Joe Varghese, Andrew McKie, Sophie Voulont, Molly Jacob
(London, UK; Paris, France; Vellore, India)
12.00 T44 The genetic suppression of NRF2 causes age-related hepatic fibrosis in a mouse model of hereditary hemochromatosis (HFE knock-out)
Tiago L. Duarte, Carolina Caldas, Ana G. Santos, Sandro Silva-Gomes, Maria João Martins,
Graça Porto, José Manuel Lopes (Porto, Portugal)
12.15 T45 The chemokine CCL2 is a novel modifier of tissue iron levels and a predictor of disease
severity in Hereditary Hemochromatosis
Katarzyna Mleczko-Sanecka, Mingang Zhu, Altamura Sandro, Maja Vujić Spasić, Claudia Guida,
Oriana Marques, Matthew Lawless, Dorine Swinkels, Fabian Bartz, Regina Maus, Jorge P. Pinto, et. al. (Heidelberg, Hannover, Germany; Porto, Portugal; Dublin, Ireland;
Radboud, The Netherlands; Irvine, USA)
12.30 Award Ceremony and Concluding Remarks
13.00 Brunch
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