Europass Curriculum Vitae Personal information First name(s) / Surname(s) Maria Pia Felli Address(es) Telephone(s) Fax(es) E-mail Department of Experimental Medicine,291, Viale Regina Elena, 00161, Roma, Italy (39 06)49255673 Mobile: (39 06)49255671 [email protected] Nationality italian Date of birth Gender Occupational (S s/d) field General Pathology (MED/04) Work experience Dates From 2001: Associate Professor of General Pathology in the Medical School of the Faculty of Medicine and Surgery of the University "La Sapienza" of Rome, Italy, Department of Experimental Medicine, Faculty of Medicine and Surgery, University of Rome, Italy. 1995-2001: Investigator, Department of Experimental Medicine, University of L’Aquila, L’Aquila, Italy Occupation or position held Main activities and responsibilities Name and address of employer Sector Associate Professor of General Pathology Research, teaching, tutorial Laboratory of Molecular Pathology, Department of Experimental Medicine, University “Sapienza”- Policlinico “UmbertoI”, Viale Regina Elena 291, 00161 Roma Molecular pathology Education and training Dates 1994-95 Post-Doc in Biotechnology and Biometry, University of L’Aquila, L’Aquila, Italy 1993: PhD doctor in Biotechnology and Biometry, University of L’Aquila, L’Aquila, Italy Title of 1986: License as a Biologist, University “La Sapienza” of Rome, Rome, Italy qualification 1984: Degree cum laude in Biology, University “La Sapienza” of Rome, Rome, Italy awarded Page 1/5 - Curriculum vitae of Surname(s) First name(s) For more information on Europass go to http://europass.cedefop.europa.eu © European Union, 2004-2010 24082010 Name and University “La Sapienza” of Rome, Rome, Italy type of University of L’Aquila, L’Aquila, Italy organisation providing education and training Personal Cell signalling and molecular pathways involved in T cell development and leukemogenesis in “in vivo” and “in vitro” skills and experimental models. competences Mother tongue(s) Other language(s) Italian English, Spanish Selfassessment Understanding Listening European level (*) Reading Language English B2 Independent user B2 Independent user Language Spanish A2 Basic user A2 Basic user Speaking Spoken interaction Writing Spoken production C1 Proficient user C1 Proficient user C1 Proficient user A2 Basic user A1 Basic user (*) Common European Framework of Reference for Languages Additional Include here any other information that may be relevant, for example contact persons, references, etc. information R Receiving Annexes List any items attached. Scientific Publication 27 articles Page 2/5 - Curriculum vitae of Surname(s) First name(s) For more information on Europass go to http://europass.cedefop.europa.eu © European Union, 2004-2010 24082010 A1 Basic user Works 1) CAMPESE A.F., GRAZIOLI P., SCAFETTA G., NOCE C., VERKHOVSKAIA S., MARI C., FELLI M.P., GULINO A., and SCREPANTI I. (2012). Deletion of NFkB/p50 influences the outcome of Notch3dependent T cell leukemia. JOURNAL OF IMMUNOLOGY, 188, May 2) BARBARULO A, GRAZIOLI P, CAMPESE A.F, BELLAVIA D, DI MARIO G, PELULLO M, CIUFFETTA A, COLANTONI S, VACCA A, FRATI L, GULINO A, FELLI M., SCREPANTI I (2011). Notch3 and canonical NFkB signaling pathways cooperatively regulate Foxp3 transcription. JOURNAL OF IMMUNOLOGY, vol. 186; p. 61996206. 3) MATTIELLO T, GUERRIERO R, LOTTI L.V, TRIFIRÒ E, FELLI M., BARBARULO A, PUCCI B, GAZZANIGA P, GAUDIO C, FRATI L, F. PULCINELLI (2011). Aspirin extrusion from human platelets through multidrug resistance protein4 mediated transport: evidence of a reduced drug action in patients after coronary artery bypass grafting. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 58; p. 752761. 4) BELLAVIA D, CHECQUOLO S, CAMPESE A. F, FELLI M., GULINO A, SCREPANTI I (2008). Notch3: from subtle structural differences to functional diversity. ONCOGENE, vol. 27; p. 50925098. 5) TALORA C, CAMPESE A.F, BELLAVIA D, FELLI M., VACCA A, GULINO A, SCREPANTI I (2008). Notch signaling and diseases: An evolutionary journey from a simple beginning to complex outcomes. BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE, vol. 1782; p. 489497. 6) VACCA A, FELLI M., PALERMO R, DI MARIO G, CALCE A, DI GIOVINE M, FRATI L, GULINO A, SCREPANTI I (2006). Notch3 and preTCR interaction unveils distinct NFkappaB pathways in T cell development and leukemia. EMBO JOURNAL, vol. 25; p. 10001008. 7) FELLI M., A. VACCA, A. CALCE, D. BELLAVIA, A.F. CAMPESE, R. GRILLO, M. DI GIOVINE, S. CHECQUOLO, C. TALORA, R. PALERMO, G. DI MARIO, L. FRATI, A. GULINO, AND I. SCREPANTI (2005). “PKCtheta mediates preTCR signaling and contributes to Notch3induced T cell leukemia”. ONCOGENE, vol. 24; p. 9921000. 8) BELLAVIA D., CAMPESE A.F., ALESSE E., VACCA A., FELLI M., BALESTRI A., STOPPACCIARO A., TIVERON C., TATANGELO L., GIOVARELLI M., GAETANO C., RUCO L., HOFFMAN E.S., HAYDAY A.C., LENDAHL U., FRATI L., GULINO A., SCREPANTI I. (2000). Constitutive activation of NFkB and T cell leukemia/lymphoma in Notch3 transgenic mice. EMBO JOURNAL, vol. 19; p. 33373348. 9) MARODER M., BELLAVIA D., VACCA A., FELLI M., SCREPANTI I. (2000). The thymus at the crossroad of the neuroimmune interactions. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 917; p. 741747. 10) SALVATORI L., RAVENNA L., FELLI M., CARDILLO M.R., RUSSO M.A., FRATI L., GULINO A., PETRANGELI E. (2000). Identification of an estrogenmediated DNAbinding independent transactivation pathway on the EGF receptor gene promoter. ENDOCRINOLOGY, vol. 141; p. 2266 2274. 11) STORTO M., DE GRAZIA U., BATTAGLIA G., FELLI M., MARODER M., GULINO A., RAGONA G., NICOLETTI F., SCREPANTI I, FRATI L., CALOGERO A. (2000). Expression of metabotropic glutamate receptors in murine thymocytes and thymic stromal cells. JOURNAL OF NEUROIMMUNOLOGY, vol. 109; p. 112120. 12) FELLI M., MARODER M., MITSIADIS T.M., CAMPESE A.F., SCARPA S., BELLAVIA D., VACCA A., MANN R.S., FRATI L, LENDAHL U., GULINO A. SCREPANTI I. (1999). Expression pattern of Notch1, 2 and 3 and Jagged 1 and 2 in lymphoid and stromal thymus components: distinct ligand receptor interactions in thymocyte development. INTERNATIONAL IMMUNOLOGY, vol. 11; p. 1017 1025. 13) FELLI M., MOSCHELLA C., FARINA A.R., ALESSE E., SCREPANTI I., TETI D., FRATI L., GULINO A. (1996). Prostaglandin E2 inhibits the interleukin2 promoter activity through down regulation of the octdependent transcription of the octamer motif. CELLULAR IMMUNOLOGY, vol. 172; p. 229234. 14) RAVENNA L., LUBRANO C., DI SILVERIO F., VACCA A., FELLI M., MARODER M., D'ERAMO G., SCIARRA F., FRATI L., GULINO A., PETRANGELI E. (1995). Androgenic and antiandrogenic control on Epidermal Growth Factor, Epidermal Growth Factor Receptor, and Androgen Receptor expression in human prostate cancer cell line LN CaP. PROSTATE, vol. 26; p. 290298. 15) FELLI M., DE GRAZIA U., VACCA A., FARINA A.R., MARODER M., CAPPABIANCA L., MECO D., FARINA M., SCREPANTI I., FRATI L., GULINO A. (1994). Positive and negative regulation of the composite octamer motif of the interleukin 2 enhancer by AP1, OCT2, and Retinoic Acid Receptor. JOURNAL OF EXPERIMENTAL MEDICINE, vol. 180; p. 14851497. 16) MARODER M., FARINA A.R., VACCA A., FELLI M., MECO D., SCREPANTI I., FRATI L., GULINO A. (1993). Cell specific bifunctional role of jun oncogene, family members upon glucocorticoid receptordependent transcription. MOLECULAR ENDOCRINOLOGY, vol. 7; p. 570584. 17) VACCA A., FELLI M., FARINA A.R., MARTINOTTI S, MARODER M., SCREPANTI I., MECO D., Page 3/5 - Curriculum vitae of Surname(s) First name(s) For more information on Europass go to http://europass.cedefop.europa.eu © European Union, 2004-2010 24082010 18) DE CAPOA A., ALEIXANDRE C., FELLI M., RAVENNA L., COSTANTINO M.A., GIANCOTTI P., VICENTI O., POGGESI I., GRAPPELLI C., MILLER D.A. (1991). Inheritance of ribosomal gene activity and level of DNA methylation of individual gene clusters in a three generation family. HUMAN GENETICS, vol. 88; p. 146-152. 19) FELLI M., VACCA A., MECO D., SCREPANTI, FARINA A.R., MARODER M., MARTINOTTI S., PETRANGELI E., FRATI L., GULINO A. (1991). Retinoic acid-induced down-regulation of the Interleukin-2 promoter via cis-regulatory sequences containing an octamer motif. MOLECULAR AND CELLULAR BIOLOGY, vol. 11; p. 4771-4778. 20) SCREPANTI I., FELLI M., TONIATO E., MECO D., MARTINOTTI S., FRATI L., SANTONI A., GULINO A (1991). Enhancament of natural killer cell susceptibility of human breast cancer cells by estradiol and v-Ha-ras oncogene. INTERNATIONAL JOURNAL OF CANCER, vol. 47; p. 445-449 21) VACCA A., MARTINOTTI S., SCREPANTI I., MARODER M., FELLI M., FARINA A.R., GISMONDI A., SANTONI A., FRATI L., GULINO A. (1990). Transcriptional regulation of the interluekin 2 gene by glucocorticoid hormones . THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265; p. 8075-8080. 22) VACCA A, MARTINOTTI S, SCREPANTI I, MARODER M, FELLI M., FARINA AR, GISMONDI A, SANTONI A, FRATI L, GULINO A. (1990). Transcriptional regulation of the interleukin 2 gene by glucocorticoid hormones. Role of steroid receptor and antigen-responsive 5'-flanking sequences. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265; p. 8075-8080. 23) BALDINI A., FELLI M., RAVENNA L., CAMAIONI A., DE CAPOA A., SPADONI G.L., CIANFARANI S., BOSCHERINI B. (1988). Differential ribosomal gene responsiveness to human growth hormone is visualized by selective silver staining. CYTOGENETICS AND CELL GENETICS, vol. 47; p. 22-25, ISSN: 0301-0171 24) DE CAPOA A., FELLI M., BALDINI A., ROCCHI M., ARCHIDIACONO N., ALEIXANDRE C., MILLE O.J., MILLER D.A. (1988). Relationship between the number and function of human ribosomal genes. HUMAN GENETICS, vol. 79; p. 301-304, ISSN: 0340-6717 25) SPADONI G.L., CIANFARANI S., BALDINI A., RAVENNA L., FELLI M., CAMAIONI A., MANCA BITTI M.L., SCIRÈ G., BOSCHERINI B., DE CAPOA A. (1988). Laron dwarfism: cellular unresponsiveness to GH demonstrated on cultured lymphocytes by a cytochemical method. HORMONE AND METABOLIC RESEARCH, vol. 20; p. 450-452, ISSN: 0018-5043 26) BALDINI A., CAMAIONI A., DE CAPOA A., FELLI M., MARLEKAJ P., RAVENNA L., CIANFARANI S., SPADONI G.L., BOSCHERINI B. (1986). Growth hormone-induced activation of rRNA gene clusters:cellular responses of normal subjects and pituitaric dwarfs. CELL BIOLOGY INTERNATIONAL REPORTS, vol. 10; p. 202, ISSN: 0309-1651 27) DE CAPOA A.ARCHIDIACONO N., MARLEKAJ P., BALDINI A., FELLI M., ARCHIDIACONO N., CIANFARANI S., SPADONI G.L., BOSCHERINI B. (1986). Growth hormone-induced regulation of rRNA gene activity in human cultured cells. HORMONE AND METABOLIC RESEARCH, vol. 18; p. 574-575, ISSN: 0018-5043 Page 4/5 - Curriculum vitae of Surname(s) First name(s) For more information on Europass go to http://europass.cedefop.europa.eu © European Union, 2004-2010 24082010 Textbooks (Chapters, etc.) 1. VACCA A, FELLI M.P., A.R. FARINA, D. MECO, M. MARODER, I. SCREPANTI, S. MARTINOTTI, E. PETRANGELI, U. DE GRAZIA, L. FRATI, A. GULINO (1993). Nuclear hormone receptor interference with interleukin 2 promoter activating signals. Progress in Endocrinology. p. 42-44, NEW YORK: The Partrhenon Publishing Group. Page 5/5 - Curriculum vitae of Surname(s) First name(s) For more information on Europass go to http://europass.cedefop.europa.eu © European Union, 2004-2010 24082010
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