Supplementary appendix

Supplementary appendix
This appendix formed part of the original submission and has been peer reviewed.
We post it as supplied by the authors.
Supplement to: Pignata S, Scambia G, Katsaros D, et al, and Gynecologic Cancer
InterGroup (GCIG) Investigators . Carboplatin plus paclitaxel once a week versus
every 3 weeks in patients with advanced ovarian cancer (MITO-7): a randomised,
multicentre, open-label, phase 3 trial. Lancet Oncol 2014; published online February 28.
http://dx.doi.org/10.1016/S1470-2045(14)70049-X.
Randomised multicentre phase III study comparing weekly versus every-3-week carboplatin
plus paclitaxel in patients with advanced ovarian cancer: the MITO-7 (Multicentre Italian
Trials in Ovarian cancer) – ENGOT-OV-10 (European Network of Gynaecological
Oncological Trial Groups) - GCIG (Gynecologic Cancer InterGroup) trial.
Web appendix
Summary
Trial scheme ....................................................................................................................................................................... 2
Figure 1A ........................................................................................................................................................................ 2
Details of compliance ......................................................................................................................................................... 2
Number of cycles ............................................................................................................................................................ 2
Table A1 ......................................................................................................................................................................... 2
Dose intensity ................................................................................................................................................................. 3
Table A2 ......................................................................................................................................................................... 3
Table A3 ......................................................................................................................................................................... 3
Figure A2 ........................................................................................................................................................................ 4
Institutions enrolling patients.............................................................................................................................................. 5
Table A4 ......................................................................................................................................................................... 5
List of the coauthors ........................................................................................................................................................... 7
Italy ................................................................................................................................................................................. 7
France ............................................................................................................................................................................. 8
1
Trial scheme
The trial scheme is reported in Figure 1A
Figure 1A
Details of compliance
Number of cycles
Information on the number of received cycles is available for 400 out of 404 patients included in the mITT population
in the standard arm and in 401 out of 406 patients included in the mITT population in the experimental arm. As clearly
shown in table A1, there is a slightly lower compliance in the experimental arm, particularly evident at the 6th cycle that
was delivered to 90% of the patients in the standard arm and to 83.3% of those in the experimental arm.
Table A1
Number of cycles
Standard arm
(every-3-week)
week)
N=404
Experimental arm
(weekly)
N=406
unknown*
4
5
0
-
4 (1.0%)
1
7 (1.75%)
13 (3.2%)
2
6 (1.5%)
6 (1.5%)
3
13 (3.25%)
23 (5.7%)
4
9 (2.25%)
9 (2.2%)
5
5 (1.25%)
12 (3.0%)
6
360 (90.0%)
334 (83.3%)
* not included in the denominator for calculation of percentages
2
Dose intensity
Dose intensity is the consequence of delays, dose reductions and doses actually delivered of each drug at each cycle.
In table A2, we report delays and dose reductions occurred in the trial. Delays include both those due to toxicity, those
produced by logistic reasons (this explains why there are 5 delays of first cycle in the standard arm) and those derived
from the execution of interval debulking surgery. Delays are more frequent (at single cycles and overall) in the weekly
arm while dose-reductions are more frequent in the every-3-week standard arm. Both figures are expected because (i) a
priori, the chance of delaying is higher in the weekly arm in the weekly arm considering that in this arm a cycle was
labelled as “delay” if at least one of the three administrations was delayed, and because (ii) it is reasonable that dose
reduction were more frequently applied in the arm with standard doses rather than in the weekly arm where the planned
doses were already very low.
Table A2
Standard arm
Pts. treated
Delay
Dose reduction
Experimental arm
Pts. treated
Delay
Dose reduction
Cycle 1
Cycle 2
Cycle 3
Cycle 4
Cycle 5
Cycle 6
Any cycle
400
5 (1%)
12 (3%)
393
42 (11%)
27 (7%)
387
71 (18%)
37 (10%)
374
101 (27%)
50 (13%)
365
112 (31%)
59 (16%)
360
106 (30%)
70 (19%)
400
249 (62%)
142 (36%)
397
49 (12%)
10 (2%)
384
107 (28%)
12 (3%)
378
152 (40%)
23 (6%)
355
153 (40%)
19 (5%)
346
134 (39%)
31 (9%)
334
96 (29%)
29 (9%)
397
315 (79%)
76 (19%)
Administered doses, scattered by arm, drug and cycle, are summarised in the table A3.
Table A3
Cycle 1
Cycle 2
Standard arm
Pts. treated
400
393
Carboplatin
Pts. evaluable
397
392
Median AUC
5.98
5.96
(IQR)
(5.11 – 6.00)
(5.01 – 6.00)
Median %
99.7%
99.4%
(IQR)
(85.2% - 100.0%) (83.5% - 100.0%)
Paclitaxel
Pts. evaluable
399
392
Median mg/m2
174.83
174.83
(IQR)
(174.19 – 175.00) (173.65 – 175.00)
Median %
99.9%
99.9%
(IQR)
(99.5% - 100.0%) (99.2% - 100.0%)
Experimental arm
Pts. treated
397
384
Carboplatin
Pts. evaluable
385
367
Median AUC
6.00
6.00
(IQR)
(5.83 – 6.00)
(5.62 – 6.00)
Median %
99.9%
100.0%
(IQR)
(95.5% - 100.0%) (93.7% - 100.0%)
Paclitaxel
Pts. evaluable
396
382
Median mg/m2
179.66
179.62
(IQR)
(177.98 – 180.00) (176.50 – 180.00)
Median %
99.8%
99.8%
(IQR)
(98.9% - 100.0%) (98.1% - 100.0%)
Footnote: AUC = area under the curve; IQR = interquartile range
Cycle 3
Cycle 4
Cycle 5
Cycle 6
387
374
365
360
385
363
357
351
5.94
5.93
5.92
5.79
(5.00 – 6.00)
(5.00 – 6.00)
(5.00 – 6.00)
(5.00 – 6.00)
98.9%
98.8%
98.6%
96.6%
(83.3% - 100.0%) (83.3% - 100.0%) (83.3% - 100.0%) (83.3% - 100.0%)
385
367
357
354
174.73
174.70
174.61
174.52
(173.08 – 175.00) (172.41 – 175.00) (169.87 – 175.00) (153.59 – 175.00)
99.8%
99.8%
99.8%
99.7%
(98.9% - 100.0%) (98.5% - 100.0%) (97.1% - 100.0%) (87.8% - 100.0%)
378
355
346
334
357
338
325
319
6.00
6.00
5.98
5.98
(5.36 – 6.00)
(5.59 – 6.00)
(5.19 – 6.00)
(5.04 – 6.00)
100.0%
100.0%
99.7%
99.7%
(89.4% - 100.0%) (93.2% - 100.0%) (86.6% - 100.0%) (83.9% - 100.0%)
375
354
344
334
179.60
179.65
179.64
179.25
(175.70 – 180.00) (175.86 – 180.34) (173.36 – 180.40) (172.77 – 180.00)
99.8%
99.8%
99.8%
99.6%
(97.6% - 100.0%) (97.7% - 100.2%) (96.3% - 100.2%) (96.0% - 100.0%)
3
Figure A2 shows the overall relative dose-intensity
dose
of each single drug in the two arms and shows that for both drugs
there was a slightly lower relative dose--intensity in the weekly arm versus the every-3-week
week arm.
arm Median values
reported in the figure are 82.7% (interquartile range 70.1% - 94.8%) and 86.8%
% (interquartile range 72.4% - 94.6%) for
carboplatin and paclitaxel in the every-33-week arm, respectively, and 76.6% (interquartile range 64.1% - 87.5%) and
79.1% (interquartile range 66.9% - 89.3%) for the two drugs in the weekly arm, respectively.
Figure A2
Box-plot of relative dose-intensity
intensity of each drug by treatment arm. Line in the box: median value. Box hinges: 25–75th
75th percentiles; ends of the
segments: 10–90th percentiles; dots: 5–95th
95th percentiles. Blue boxes: every-3-week
every
arm; red boxes: weekly arm.
4
Institutions enrolling patients
Table A4 reports the Institutions enrolling patients and their Principal Investigators by the number of patients enrolled.
Table A4
Institutions enrolling patients
Dipartimento per la Tutela della Salute della Donna, della Vita Nascente, del Bambino e
dell' Adolescente, Università Cattolica del Sacro Cuore (Roma, Italy)
Dipartimento di Oncologia Uroginecologica, Istituto Nazionale Tumori – Fondazione
G.Pascale IRCCS (Napoli, Italy)
Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II (Napoli,
Italy)
Unità di Ginecologia Oncologica, Fondazione IRCCS Istituto Nazionale Tumori
(Milano, Italy)
Dipartimento di Scienze Ginecologico-Ostetriche e Scienze Urologiche, Università La
Sapienza (Roma, Italy)
Ginecologia ed Ostetricia, Policlinico (Bari, Italy)
Azienda Ospedaliera Città della Salute e della Scienza di Torino, Presidio S. Anna e
Università di Torino, SCDO 3, Ginecologia Oncologica (Torino, Italy)
Oncologia Medica C - Centro di Riferimento Oncologico (Aviano-PN, Italy)
Oncologia ed Ematologia, AO Carlo Poma (Mantova)
Ginecologia Oncologica, Centro di Ricerca e Formazione ad Alta Tecnologia nelle
Scienze Biomediche, Università Cattolica del Sacro Cuore (Campobasso, Italy)
Oncologia Medica Ospedale S. Giovanni Calibita Fatebenefratelli (Roma, Italy)
Oncologia Medica Ospedale S. Chiara (Trento, Italy)
Dipartimento di Oncologia AO S. Maria della Misericordia (Udine, Italy)
Oncologia Medica, Azienda Ospedaliera ASMN, IRCCS (Reggio Emilia, Italy)
Oncologia Medica, Ospedale Antonio Perrino (Brindisi, Italy)
Ginecologia ed Ostetricia, AO V. Cervello (Palermo, Italy)
Oncologia Medica, Ospedale Oncologico (Bari, Italy)
Oncologia Medica, AOUP (Modena, Italy)
Ginecologia ed Ostetricia, Ospedale A. Manzoni (Lecco - CO, Italy)
Ginecologia Oncologica, AO Ordine Mauriziano (Torino, Italy)
Oncologia Medica, AO S.Maria della Misericordia (Perugia, Italy)
Oncologia, Ospedale Fatebenefratelli (Benevento, Italy)
Oncologia Medica, Ospedale Renzetti (Lanciano – CH, Italy)
Clinica Ostetrico-Ginecologica IRCCS S.Matteo (Pavia, Italy)
Oncologia Medica, AO Vito Fazzi (Lecce, Italy)
Oncogard - Clinique Valdegour (Nimes, France)
Oncologia, AO S.Maria degli Angeli (Pordenone, Italy)
Centre Hospitalier Intercommunal (Créteil, France)
III Clinica Ostetrica e Ginecologica, Università (Bari, Italy)
Oncologia Medica, Università G. D’Annunzio (Chieti, Italy)
Oncologia ed Ematologia Oncologica, U.L.S.S. 13 (Mirano – VE, Italy)
Oncologia Medica A, Istituto Regina Elena (Roma, Italy)
Medicina Oncologica, Ospedale Ramazzini di Carpi e Ospedale di Mirandola (Carpi –
MO, Italy)
Centre Alexis Vautrin (Vandoeuvre-Les-Nancy, France)
Centre d'Oncologie Saint-Yves (Vannes, France)
CRLC Val d'Aurelle (Montpellier, France)
Centre Hospitalier Universitaire Caremeau (Nimes, France)
Oncologia Medica, Policlinico Giaccone (Palermo, Italy)
Onco-Ematologia, Ospedale Andrea Tortora (Pagani – SA, Italy)
Oncologia Ginecologica, Ospedale S.Gerardo (Monza, Italy)
Oncologia, AOU (Parma, Italy)
Oncologia Medica, Ospedale San Donato (Arezzo, Italy)
Oncologia Medica, Ospedale Mazzoni (Ascoli Piceno, Italy)
Hôpital de Chambéry (Chambéry, France)
Centre Hospitalier Bretagne Sud (Lorient, France):
Oncologia Medica, AO Bianchi Melacrino Morelli (Reggio Calabria, Italy)
Ostetricia e Ginecologia, Ospedale Cannizzaro (Catania, Italy)
Oncologia Clinica, AOU Arcispedale Sant'Anna (Ferrara, Italy)
Oncologia Medica, Ospedale Boldrini (Thiene - VI, Italy)
Clinique Francheville (Perigueux, France)
Hôpital Hôtel-Dieu (Paris, France)
Hôpital Foch (Suresnes, France)
Centre Hospitalier Universitaire Dupuytren (Limoges, France)
Oracle - Centre d'Oncologie de Gentilly (Nancy, France)
Centre Hospitalier de Cholet (Cholet, France)
Number of
patients
enrolled
PI*
129
Giovanni Scambia
92
Sandro Pignata
52
Sabino De Placido
40
Francesco Raspagliesi
39
Pierluigi Benedetti Panici
38
Luigi Selvaggi
30
Dionyssios Katsaros
26
24
Roberto Sorio
Enrico Aitini
23
Gabriella Ferrandina
22
21
20
19
16
13
12
12
11
10
9
9
9
9
8
8
7
7
6
6
5
5
Enrico Breda
Viviana Murgia
Cosimo Sacco
Corrado Boni
Saverio Cinieri
Desiderio Gueli Alletti
Emanuele Naglieri
Roberto Sabbatini
Antonio Pellegrino
Annamaria Ferrero
Anna Maria Mosconi
Antonio febbraro
Antonio Nuzzo
Luciana Babilonti
Vito Lorusso
Eric Legouffe
Giovanni Lo Re
Emmanuelle Malaurie
Emilia Mele
Stefano Iacobelli
Grazia Artioli
Antonella Savarese
5
Lucia Longo
5
5
5
5
4
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
Beatrice Weber
Emmanuel Blot
Michel Fabbro
Catherine Ferrer
Antonio Russo
Antonietta Fabbrocini
Andrea Lissoni
Maria Angela Bella
Sabrina Del Buono
Donatella Morale
Isabelle Cauvin
Isabelle Cumin
Mario Nardi
Paolo Scollo
Marina Marzola
Alessandra Perin
Laurent Cany
Eric Pujade-Lauraine
Mehran Khatibi
Sandrine Lavau-Denes
Célia Roemer-Becuwe
Alain Zannetti
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Clinique Armoricaine de Radiologie (Saint-Brieuc, France)
Oncologia Medica, Azienda Ospedaliera G. Rummo (Benevento, Italy)
Oncologia Medica, Ospedale S. Spirito (Pescara, Italy)
Oncologia medica, Ospedale S. Massimo (Penne – PE, Italy)
Hôpital Notre-Dame de Bon Secours (Metz, France)
Hôpital Drôme Nord - Site de Romans (Romans-Sur-Isere, France)
Centre Hospitalier William Morey (Chalon-Sur-Saone, France)
Centre de Radiothérapie - Clinique Sainte-Anne (Strasbourg, France)
Centre Hospitalier Bretagne Atlantique (Vannes, France)
Centre Hospitalier Départemental Les Oudairies (La Roche-Sr-Yon, France)
Clinique de la Sauvegarde (Lyon, France)
Centre Hospitalier du Mans (Le Mans, France)
* The Principal Investigator might not be reported in the list of coauthors
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1
1
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Anne-Claire Hardt-Bessard
Bruno Daniele
Marco Lombardo
Donato Natale
Christian Platini
Marie-Claude Gouttebel
Bruno Salles
Louis-Marie Dourthe
Emmanuel Blot
Franck Priou
Isabelle Moullet
Nathalie Denizon
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List of the coauthors
[centre (town): physicians; research nurses; data managers]
Italy
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Dipartimento per la Tutela della Salute della Donna, della Vita Nascente, del Bambino e dell' Adolescente,
Università Cattolica del Sacro Cuore (Roma): Giovanni Scambia, Vanda Salutari, Caterina Ricci, Rosa De
Vincenzo, Mariagrazia Di Stefano, Valeria Masciullo, Maria Lisa Scarciglia, Floriana Mascilini, Alessia Di
Legge, Antonella Pietragalla, Giulia Amadio, Carmine Conte; Michela Panella; Francesca Capobianco,
Martina Radicella.
Dipartimento di Oncologia Uroginecologica, Istituto Nazionale Tumori Fondazione G.Pascale - IRCCS
(Napoli): Sandro Pignata, Carmela Pisano, Stefano Greggi, Marilena Di Napoli, Sabrina Chiara Cecere, Rosa
Tambaro, Gaetano Facchini, Carla Cavaliere; Carmelina Landolfi, Vincenza Lanza, Adele Tatarella; Balbina
Apice, Antonietta Linardi.
Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II (Napoli): Sabino De Placido,
Rossella Lauria, Brigida Stanzione, Monica Milano, Piera Gargiulo, Carmine De Angelis, Valeria Forestieri,
Alessandra Vernaglia Lombardi, Domenico Malzoni (Casa di cura Malzoni-Villa dei Platani, Avellino);
Antonio Pepe.
Unità di Ginecologia Oncologica, Fondazione IRCCS Istituto Nazionale Tumori (Milano): Francesco
Raspagliesi, Domenica Lorusso, Flavia Zanaboni, Maria Mancini, Italo Sarno, Antonino Ditto, Fabio
Martinelli; Elisa Grassi, Dominique Ronzulli; Patrizia Angela Valente, Ylenia Ponti.
Dipartimento di Scienze Ginecologico-Ostetriche e Scienze Urologiche, Università La Sapienza (Roma):
Pierluigi Benedetti Panici, Claudia Marchetti, Angela Musella, Laura Salerno, Innocenza Palaia, Filippo
Bellati, Giorgia Perniola.
Ginecologia ed Ostetricia, Policlinico (Bari): Gennaro Cormio, Luigi Selvaggi, Vera Loizzi, Anna
Camporeale, Luca Leone, Emma Bassi, Paola De Mitri; Teresa Loverre.
Ginecologia Oncologica, Azienda Ospedaliera Città della Salute e della Scienza, Presidio S. Anna e Università
(Torino): Dionyssios Katsaros , Saverio Danese, Emilie Marion Canuto, Elena Bertone, Gianluca Gregori.
Oncologia Medica C - Centro di Riferimento Oncologico (Aviano-PN): Roberto Sorio, Simona Scalone,
Davide Lombardi, Giorgio Giorda, Emilio Lucia ; Anna Maria Colussi; Gianna Tabaro.
Oncologia ed Ematologia, AO Carlo Poma (Mantova): Maria Giovanna Cavazzini, Francesca Adami, Carla
Rabbi, Rita Cengarle, Mariabeatrice Pisanelli, Enrico Aitini; Patrizia Morselli.
Ginecologia Oncologica, Centro di Ricerca e Formazione ad Alta Tecnologia nelle Scienze Biomediche,
Università Cattolica del Sacro Cuore (Campobasso): Gabriella Ferrandina, Francesco Legge.
Oncologia Medica Ospedale S. Giovanni Calibita Fatebenefratelli (Roma): Enrico Breda, Diego Signorelli,
Filippo Greco, Giuditta di Isernia, Antonella Mecozzi.
Oncologia Medica Ospedale S. Chiara (Trento): Viviana Murgia, Alessia Caldara, Arrigo Nozza, Chiara Del
Pezzo.
Dipartimento di Oncologia, Azianda Ospedaliera Universitaria S. Maria della Misericordia (Udine): Cosimo
Sacco, Claudia Andreetta, Paola Ermacora, Gianpiero Fasola, Michela Cozzi; Paola Costantini; Silvia Ellero.
Oncologia Medica, Arcispedale S. Maria Nuova (Reggio Emilia): Alessandra Bologna, Corrado Boni, Nuria
Maria Asensio Sierra, Francesca Zanelli, Silvia Fanello; Roberta Gnoni, Elena Magnani, Giovanna Stridi,
Erika Gervasi.
Oncologia Medica, Ospedale Antonio Perrino (Brindisi): Saverio Cinieri, Enrica Mazzoni, Concetta Chetrì,
Maria D'Amico, Chiara Caliolo; Liana Letizia Falcone, Maria Pinto, Giuseppe Lotti; Margherita Cinefra,
Pasqualinda Ferrara.
Ginecologia ed Ostetricia, AO V. Cervello (Palermo): Desiderio Gueli Alletti, Nenzi Varsellona, Andrea
Benedetto Di Stefano; Concetta Allotta.
Oncologia Medica, Ospedale Oncologico (Bari): Emanuele Naglieri, Anila Kardhashi, Vito Trojano ; Lucrezia
Spadone; Sabina Delcuratolo.
Oncologia Medica, AOUP (Modena): Roberto Sabbatini, Cristina Masini, Angela Toss; Pasquale Mighali.
Ginecologia ed Ostetricia, Ospedale A. Manzoni (Lecco - CO): Stefania Dell’Oro, Ilaria Colombo, Silvia
Corso; Attilia Ravasi, Stella Monti, Roberta Monti; Micol Gilardoni, Angelita Lagati, Mario Villa, Davide
Colombo.
Ginecologia Oncologica, AO Ordine Mauriziano (Torino): Annamaria Ferrero, Elisa Tripodi, Stefania Perotto.
Oncologia Medica, AO S.Maria della Misericordia (Perugia): Anna Maria Mosconi, Paola Anastasi; Anna Rita
Presciutti, Mariangela Ceccarini, Alessandra Traversini; Massimiliano Ferraldeschi, Fabiana Marchetti, Sara
Baglivo.
Oncologia, Ospedale Fatebenefratelli (Benevento): Antonio Febbraro, Ilaria Spagnoletti.
Oncologia Medica, Ospedale Renzetti (Lanciano – CH): Antonio Nuzzo, Nicola D'Ostilio.
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Clinica Ostetrico-Ginecologica IRCCS S.Matteo (Pavia): Arsenio Spinillo, Luciana Babilonti.
Oncologia Medica, AO Vito Fazzi (Lecce): Vito Lorusso, Graziana Ronzino; Valeria Saracino.
Oncologia, AO S.Maria degli Angeli (Pordenone): Giovanni Lo Re, Davide Santeufemia; Antonino Ius.
III Clinica Ostetrica e Ginecologica, Università (Bari): Emilia Mele, Valeria Vincenza Fumarulo; Nicoletta
Cafagno, Isabella Garofalo.
Oncologia Medica, Università G. D’Annunzio (Chieti): Luciana Irtelli, Alessandra Di Paolo.
Oncologia ed Ematologia Oncologica, U.L.S.S. 13 (Mirano – VE): Grazia Artioli, Giuseppe Azzarello.
Oncologia Medica A, Istituto Regina Elena (Roma): Antonella Savarese, Enrico Vizza; Agnese Provenziani.
Medicina Oncologica, Ospedale Ramazzini di Carpi e Ospedale di Mirandola (Carpi – MO): Lucia Longo,
Alessia Ferrari; Giorgia Razzini, Roberta Guerzoni.
Oncologia Medica, Policlinico Giaccone (Palermo): Antonio Russo.
Onco-Ematologia, Ospedale Andrea Tortora (Pagani – SA): Antonietta Fabbrocini; Linda Alvino, Concetta
Ingenito, Annapaola Campana, Patrizia De Prisco.
Oncologia Ginecologica, Ospedale S.Gerardo (Monza): Valentina Chiappa.
Oncologia, AOU (Parma): Maria Angela Bella; Leonarda Ferri; Elena Rapacchi, Roberta Camisa.
Oncologia Medica, Ospedale San Donato (Arezzo): Sabrina Del Buono; Samanta Capacci.
Oncologia Medica, Ospedale Mazzoni (Ascoli Piceno): Donatella Morale.
Oncologia Medica, AO Bianchi Melacrino Morelli (Reggio Calabria): Pietro Del Medico; Antonella Falzea.
Ostetricia e Ginecologia, Ospedale Cannizzaro (Catania): Paolo Scollo.
Oncologia Clinica, AOU Arcispedale Sant'Anna (Ferrara): Marina Marzola; Elena Raisi, Giovanna Chiara
Surace.
Oncologia Medica, Ospedale Boldrini (Thiene - VI): Alessandra Perin.
Oncologia Medica, Azienda Ospedaliera G. Rummo (Benevento): Lucia Cannella.
Oncologia Medica, Ospedale S. Spirito (Pescara): Cristina Amatetti.
Oncologia medica, Ospedale S. Massimo (Penne – PE): Bruna Fornarini.
Unità di Statistica Medica, Seconda Università di Napoli (Napoli): Ciro Gallo, Simona Signoriello, Giuseppe
Signoriello, Paolo Chiodini.
Unità Sperimentazioni Cliniche, Istituto Nazionale Tumori Fondazione G.Pascale - IRCCS (Napoli):
Francesco Perrone, Massimo Di Maio, Maria Carmela Piccirillo, Gennaro Daniele, Alessandro Morabito; Jane
Bryce; Giuliana Canzanella, Federika Crudele, Francesca Laudato, Cristiana de Luca, Giovanni de Matteis,
Manuela Florio, Fiorella Romano, Antonia Del Giudice, Marilena Martino, Maria Teresa Ribecco, Alfonso
Savio, Lucia Sparavigna.
France
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Oncogard - Clinique Valdegour (Nimes): Jacques Cretin, Eric Legouffe.
Centre Hospitalier Intercommunal (Créteil): Emmanuelle Malaurie, Stéphane Henault.
Centre Alexis Vautrin (Vandoeuvre-Les-Nancy): Beatrice Weber, Marie Christine Kaminsky.
Centre d'Oncologie Saint-Yves (Vannes): Emmanuel Blot.
CRLC Val d'Aurelle (Montpellier): Michel Fabbro.
Centre Hospitalier Universitaire Caremeau (Nimes): Catherine Ferrer.
Hôpital de Chambéry (Chambéry): Isabelle Cauvin.
Centre Hospitalier Bretagne Sud (Lorient): Isabelle Cumin.
Clinique Francheville (Perigueux): Laurent Cany.
Hôpital Hôtel-Dieu (Paris): Eric Pujade-Lauraine.
Hôpital Foch (Suresnes): Mehran Khatibi.
Centre Hospitalier Universitaire Dupuytren (Limoges): Sandrine Lavau-Denes.
Oracle - Centre d'Oncologie de Gentilly (Nancy): Célia Roemer-Becuwe.
Centre Hospitalier de Cholet (Cholet): Alain Zannetti.
Clinique Armoricaine de Radiologie (Saint-Brieuc): Anne-Claire Hardt-Bessard.
Hôpital Notre-Dame de Bon Secours (Metz): Christian Platini.
Hôpital Drôme Nord - Site de Romans (Romans-Sur-Isere): Marie-Claude Gouttebel.
Centre Hospitalier William Morey (Chalon-Sur-Saone): Bruno Salles.
Centre de Radiothérapie - Clinique Sainte-Anne (Strasbourg): Louis-Marie Dourthe.
Centre Hospitalier Bretagne Atlantique (Vannes): Emmanuel Blot.
Centre Hospitalier Départemental Les Oudairies (La Roche-Sr-Yon): Franck Priou.
Clinique de la Sauvegarde (Lyon): Isabelle Moullet.
Centre Hospitalier du Mans (Le Mans): Nathalie Denizon.
ARCAGY – GINECO Hôpital Hôtel Dieu (Paris): Benedicte Votan, Frederic Marmion.
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