Registration Form Speakers and Chairpersons (please copy and return to Alessandra Roncaglioni within 04th Dec 2014: fax 02-39014735 or e-mail [email protected]) - Jürgen Arning – UBA, Dessau-Roßlau (D) - Anna Auzzi - Polynt, S. Giovanni Valdarno (I) - Emilio Benfenati – IRFMN, Milan (I) - Livia Biardi – Altroconsumo, Milan (I) - Raffaella Butera – Toxicon srl & UniPavia, Pavia (I) - Francesca Caloni – UniMilano, Milan (I) - Valeria Croce – ChemService, Novate Milanese (I) - Pietro Cozzini – UniParma (I) - Ferdinando Fiorino – UniNeaples (I) - Elena Lo Piparo – Nestlè, Lausanne (CH) - Stefano Lorenzetti – ISS, Rome (I) - Alberto Mantovani – ISS, Rome (I) - Elisa Perissutti – UniNeaples (I) - Alessandra Roncaglioni – IRFMN, Milan (I) - Maria Teresa Russo - CNSC-ISS, Rome (I) First name ……………………………………………… Family name …………………………………………… Affiliation ……………………………………………….. …………………………………………………………….. …………………………………………………………….. Address …………………………………………………. …………………………………………………………….. Zip code …………………………………………………. Town ………………………………………………….. Country …………………………………………………. General Info - Venue Phone ……………………………………………………. Registration is free. Workshop materials and coffee breaks are included. Accomodation and board are in charge of the participants: max number is 100. Certificates of participation. Available upon request at the end of the workshop. For any further information, please contact the Scientific Secretariat. E-mail …………………………………………………… Coffee break attendance: Dec. 10th coffee break Dec. 11th coffee break Special dietary needs: …………………………………………………………….. Scientific Secretariat Dr. Alessandra Roncaglioni Dpt. Environment and Health, Istituto Ricerche Farmacologiche Mario Negri – IRFMN Via Giuseppe La Masa, 19 – 20156 Milan (I) Phone: 39.(0)2-3901 E-mail: [email protected] Dr. Stefano Lorenzetti Dpt. Food Safety and Veterinary Public Health, Istituto Superiore di Sanità – ISS Viale Regina Elena, 299 – 00161 Rome (I) Phone: +39.(0)6-49902512 E-mail: [email protected] Venue: Istituto Ricerche Farmacologiche Mario Negri - IRFMN, Aula B via G. La Masa, 19 – 20156 Milano http://www.marionegri.it/mn/it/doveSiamo/ comeRagg.html Endocrine Disruptors in silico / in vitro – Evaluation and Substitution for Industrial Applications LIFE12 ENV/IT/000633 LIFE-EDESIA workshop on The role of in silico tools in supporting the application of the substitution principle 10th -11th December 2014 Istituto Ricerche Farmacologiche Mario Negri — IRFMN Aula B Objectives Programme - December 10th, 2014 The first LIFE-EDESIA Workshop on “The role of in silico tools in supporting the application of the substitution principle” will deal with the emerging issue of the use of computational, in silico tools in toxicological risk assessment and the research needs in order to develop and optimize such use. In silico tools are recognized as essential components of non-animal testing strategies; their relevance is further enhanced by the availability of large data sets on different chemicals. In particular, the workshop will discuss in silico tools as a scientific support to implement the substitution principle, a main pillar of the EU regulations on chemicals, first of all the REACH. A cutting-edge topic is the potential role of in silico screenings when the substances to be replaced have complex toxicity mechanisms: a telling example is endocrine disruption, a general term which includes multiple intracellular pathways. 14.30-15.00 Registration of participants The workshop is organized by the EU LIFE+ granted project LIFE-EDESIA (“Endocrine Disruptors in silico / in vitro – Evaluation and Substitution for Industrial Applications”, LIFE12 ENV/IT/000633, http:// www.iss.it/life) coordinated by the Istituto Superiore di Sanità (ISS) and it will involve contributions and expertises from research, regulators, the industry and stakeholders. 16.40-17.00 In silico approach in the REACH context: the experience from EC LIFE projects CALEIDOS, PROSIL, etc Emilio Benfenati – IRFMN 17.00-17.20 Advantages and disadvantages of in silico tools: their use in addressing EDCs Alessandra Roncaglioni – IRFMN 17.20-17.40 A computational approach to nuclear receptors screening Pietro Cozzini – UniParma 17.40-18.00 Discussion 15.00-15.05 Workshop opening Emilio Benfenati – IRFMN LIFE-EDESIA project (chairperson: S. Lorenzetti) 15.05-15.20 Introduction on LIFE-EDESIA project Alberto Mantovani – ISS 15.20-15.40 The in vitro assessment of endocrine disruptors/EDCs Stefano Lorenzetti – ISS, Rome 15.40-16.00 The role of chemical synthesis in support of the substitution principle Ferdinando Fiorino / Elisa Perissutti 16-00-16.20 Discussion 16.20-16.40 Coffee break Academic perspective (chairperson: A. Roncaglioni) Programme - December 11th, 2014 Industry and regulatory perspectives in Risk Assessment (chairperson: A. Mantovani, E. Benfenati) ) 09.00–09.20 Industrial approaches towards alternative strategies for EDCs: the food domain Elena Lo Piparo – Nestlè 09.20–09.40 Alternative strategies for EDCs: the domain of man-made chemicals Raffaella Butera – Toxicon srl & UniPavia 09.40-10.00 Discussion 10.00-10.30 Coffee break 10.30-10.50 The role of regulatory agency in addressing EDCs in the framework of REACH legislation: support from in silico tools Jürgen Arning – UBA 10.50-11.10 Last news from ECHA on alternative methods in compliance with the REACH: the Read-Across Maria Teresa Russo – CNSC-ISS 11.10-11.30 Discussion Round-table of stakeholders (chairpersons: E. Benfenati - A. Mantovani) 11.30-11.40 Livia Biardi – Altroconsumo 11.40-11.50 Valeria Croce – Chemservice 11.50-12.00 Francesca Caloni – UniMilano 12.00-12.10 Anna Auzzi - Polynt 12.00-12.30 Discussion—Question time 12.30-12.45 Concluding remarks Emilio Benfenati – IRFMN Alberto Mantovani – ISS 12.45 Farewell
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