氏名:礒 良崇(イソ ヨシタカ) 昭和大学医学部卒(H10 年) 医学博士 昭和大学藤が丘リハビリテーション病院 内科・内部障害リハビリ部門 准教授 心臓リハビリテーション室 医療連携推進室 副室長 室長 資格: 内科認定医、循環器専門医、老年病専門医、脈管専門医 心臓リハビリテーション指導士 臨床研修指導医、身体障害者認定指定医(心臓機能障害) 所属学会: 日本内科学会、日本循環器学会、日本心臓リハビリテーション学会(評議員)、 日本腎臓リハビリテーション学会(代議員)、日本動脈硬化学会(評議員)、 日本脈管学会(評議員)、日本心不全学会(評議員)、日本再生医療学会(評 議員)、日本心臓病学会、日本老年医学会、日本呼吸ケア・リハビリテーショ ン学会 活動内容: <診療> 循環器内科、心血管リハビリテーション、動脈硬化、心不全、老年病 <研究> 間葉系幹細胞による心血管再生医療、血管・筋細胞の老化と再生、 心血管領域における Rehabilitation Science 受賞歴ほか: 平成16年:昭和大学留学助成 平成19年:昭和大学医学振興財団研究助成 平成21年:日本再生医療学会 第 1 回 YIA 臨床部門優秀賞 平成25年:昭和大学医学部同窓会学術賞 平成26年:昭和大学医学・医療振興財団 医学研究助成(医療の実践)部門 競争的資金獲得: 2008―2009年度:文部科学省・日本学術振興会 科学研究費 若手研究 B:代表研究者 2010―2011年度:文部科学省・日本学術振興会 科学研究費 若手研究 B:代表研究者 2013―2015年度:文部科学省・日本学術振興会 科学研究費 基盤研究 C:代表研究者 論文業績 論文業績 ☆原著論文 2014 ・Usui S, Iso Y#, Sasai M, Mizukami T, Mori H, Watanabe T, Shioda S, Suzuki H. Kisspeptin-10 induces endothelial cellular senescence and impaired endothelial growth. Clin Sci (Lond). 2014 [Epub ahead of print] ・Usui S, Iso Y#, Sasai M, Mizukami T,Sato C,Kurata M,Spees JL, Umezawa A, Shioda S, Suzuki H. Mesenchymal Stem Cells from Bone Marrow Enhance Neovascularization and Stromal Cell Proliferation in Rat Ischemic Limb in the Early Phase after Implantation. The Showa University Journal of Medical Sciences. 2014 (in press) ・Shoji M, Furuyama F, Yokota Y, Omori Y, Sato T, Tsunoda F, Iso YY, Koba S, Geshi E, Katagiri T, Suzuki H, Kobayashi Y. IL-6 Mobilizes Bone Marrow-Derived Cells to the Vascular Wall, Resulting in Neointima Formation via Inflammatory Effects.J Atheroscler Thromb. 2014 [Epub ahead of print] 2013 ・Iso Y, Rao K, Poole CN, Zaman T, Curril I, Sobel BE, Kajstura J, Anversa P, Spees JL. Priming with ligands secreted by human stromal progenitor cells promotes grafts of cardiac stem/progenitor cells after myocardial infarction. STEM CELLS 2013 [Epub ahead of print]. ・Fujimoto K, Hayashi A, Kamata Y, Ogawa A, Watanabe T, Ichikawa R, Iso Y, Koba S, Kobayashi Y, Koyama T, Shichiri M. Circulating levels of human salusin-, a potent hemodynamic and atherogenesis regulator. PLoS ONE 2013 [Epub ahead of print]. 2012 ・Iso Y, Yamaya S, Sato T, Poole CN, Isoyama K, Mimura M, Koba S, Kobayashi Y, Takeyama Y, Spees JL, Suzuki H. Distinct Mobilization of Circulating CD271+ Mesenchymal Progenitors from Hematopoietic Progenitors during Aging and after Myocardial Infarction. Stem Cells Transl Med. 2012;1:462-8 2011 年 ・Sato T*, Iso Y*, Uyama T, Kawachi K, Wakabayashi K, Omori Y, Soda T, Shoji M, Koba S, Yokoyama SI, Fukuda N, Saito S, Katagiri T, Kobayashi Y, Takeyama Y, Umezawa A, Suzuki H. Coronary vein infusion of multipotent stromal cells from bone marrow preserves cardiac function in swine ischemic cardiomyopathy via enhanced neovascularization. Lab Invest. 2011;91:553-64. *equal contribution. ・Kawachi K, Iso Y, Sato T, Wakabayashi K, Kobayashi Y, Takeyama Y, Suzuki H. Effects of erythropoietin on angiogensis after myocardial infarction in porcine. Heart Vessels 2011;27(1):79-88. ・Watanabe T, Sato K, Itoh F, Iso Y, Nagashima M, Hirano T, Shichiri MThe roles of salusins in atherosclerosis and related cardiovascular diseases. J Am Soc Hypertens 2011;5:359-65. 2010 年 ・Iso Y, Soda T, Sato T, Sato R, Kusuyama T, Omori Y, Shoji M, Koba S, Katagiri T, Kobayashi Y, Suzuki H. Impact of implanted bone marrow progenitor cell composition on limb salvage after cell implantation in patients with critical limb ischemia. Atherosclerosis. 2010: 209:167-72. ・Mori H, Nakamachi T, Ohtaki H, Yofu S, Sato A, Endo K, Iso Y, Suzuki H, Takeyama Y, Shintani N, Hashimoto H, Baba A, Shioda S. Cardioprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on Doxorubicin-induced cardiomyopathy in mice. Circ J. 2010;74:1183-90. ・Ozawa T, Toba K, Suzuki H, Kato K, Iso Y, Akutsu Y, Kobayashi Y, Takeyama Y, Kobayashi N, Yoshimura N, Akazawa K, Aizawa Y; EPO/AMI-I Pilot Study Researchers. Single-dose intravenous administration of recombinant human erythropoietin is a promising treatment for patients with acute myocardial infarction - randomized controlled pilot trial of EPO/AMI-1 study -. Circ J. 2010;74:1415-23. 2009 年 ・Xu G, Watanabe T, Iso Y, Koba S, Sakai T, Nagashima M, Arita S, Hongo S, Ota H, Kobayashi Y, Miyazaki A, Hirano T. Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis. Circ Res. 2009;105:500-10. ・Ban Y, Watanabe T, Suguro T, Matsuyama TA, Iso Y, Sakai T, Sato R, Idei T, Nakano Y, Ota H, Miyazaki A, Kato N, Hirano T, Ban Y, Kobayashi Y. Increased plasma urotensin-II and carotid atherosclerosis are associated with vascular dementia. J Atheroscler Thromb. 2009;16:179-87. ・Suzuki H, Toba K, Kato K, Ozawa T, Tomosugi N, Higuchi M, Kusuyama T, Iso Y, Kobayashi N, Yokoyama S, Fukuda N, Saitoh H, Akazawa K, Aizawa Y. Serum hepcidin-20 is elevated during the acute phase of myocardial infarction. Tohoku J Exp Med. 2009;218:93-8. 2008 年 ・Shoji M, Iso Y, Kusuyama T, Omori Y, Soda T, Tsunoda F, Sato T, Koba S, Geshi E, Kobayashi Y, Katagiri T, Suzuki H. High-dose granulocyte-colony stimulating factor promotes neointimal hyperplasia in the early phase and inhibits neointimal hyperplasia in the late phase after vascular injury. Circ J. 2008;72:1885-93. ・Suzuki H, Kusuyama T, Sato R, Yokota Y, Tsunoda F, Sato T, Shoji M, Iso Y, Koba S, Katagiri T. Elevation of matrix metalloproteinases and interleukin-6 in the culprit coronary artery of myocardial infarction. Eur J Clin Invest. 2008;38:166-73. ・Sato T, Suzuki H, Kusuyama T, Omori Y, Soda T, Tsunoda F, Shoji M, Iso Y, Koba S, Geshi E, Katagiri T, Kawachi K, Wakabayashi K, Takeyama Y. G-CSF after myocardial infarction accelerates angiogenesis and reduces fibrosis in swine. Int J Cardiol. 2008;127:166-173. 2007 年 ・Iso Y, Spees JL, Serrano C, Bakondi B, Pochampally R, Song YH, Sobel BE, Delafontaine P, Prockop DJ. Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment. Biochem Biophys Res Commun. 2007;354:700-6. ・Soda T, Suzuki H, Iso Y, Kusuyama T, Omori Y, Sato T, Shoji M, Koba S, Geshi E, Katagiri T. Bone marrow cells contribute to neointimal formation after stent implantation in swine. Int J Cardiol. 2007;121:44-52. ・Kusuyama T, Suzuki H, Shoji M, Sato R, Omori Y, Soda T, Sato T, Iso Y, Koba S, Geshi E, Katagiri T, Nakamachi T, Otaki H, Shioda S, Sekigawa K. Deficiency of the TNF-alpha improves the recovery of blood perfusion in a mouse model of hindlimb ischemia. J Showa Medical Associaion. 2007;67:126-33. 2006 年 ・Iso Y, Suzuki H, Sato T, Shoji M, Shimizu N, Shibata M, Koba S, Geshi E, Katagiri T. Rho-kinase inhibitor suppressed restenosis in porcine coronary balloon angioplasty. Int J Cardiol. 2006;106:103-10. ・Sato T, Suzuki H, Shibata M, Kusuyama T, Omori Y, Soda T, Shoji M, Iso Y, Koba S, Geshi E, Katagiri T, Shioda S, Sekikawa K. Tumor-necrosis-factor-alpha-gene-deficient mice have improved cardiac function through reduction of intercellular adhesion molecule-1 in myocardial infarction. Circ J. 2006;70:1635-42. ・Suzuki H*, Iso Y*, Kusuyama T, Omori Y, Soda T, Sato T, Shoji M, Koba S, Geshi E, Katagiri T. Neutrophil and erythroblast regulate the effects of bone marrow cell implantation. Eur J Clin Invest. 2006;36:65-6. * equal contribution. ・Suzuki H, Kusuyama T, Omori Y, Soda T, Tsunoda F, Sato T, Shoji M, Iso Y, Kondo T, Koba S, Geshi E, Katagiri T. Inhibitory effect of candesartan cilexetil on left ventricular remodeling after myocardial infarction. Int Heart J. 2006;47:715-25. ・Koba S, Hirano T, Ito Y, Tsunoda F, Yokota Y, Ban Y, Iso Y, Suzuki H, Katagiri T. Significance of small dense low-density lipoprotein-cholesterol concentrations in relation to the severity of coronary heart diseases. Atherosclerosis. 2006;189:206-14. ・Wakabayashi K, Suzuki H, Sato T, Iso Y, Katagiri T, Takeyama Y. Eplerenone suppresses neointimal formation after coronary stent implantation in swine. Int J Cardiol. 2006;107:260-6. 2005 年 ・Iso Y, Suzuki H, Sato T, Shoji M, Shibata M, Shimizu N, Koba S, Geshi E, Katagiri T. The mechanism of in-stent restenosis in radius stent: an experimental porcine study. Circ J. 2005;69:481-7. ・Suzuki H, Sato R, Sato T, Shoji M, Iso Y, Kondo T, Shibata M, Koba S, Katagiri T. Time-course of changes in the levels of interleukin 6 in acutely decompensated heart failure. Int J Cardiol. 2005;100:415-20. ・Koba S, Tsunoda F, Hirano T, Iso Y, Suzuki H, Geshi E, Katagiri T. Postprandial changes in LDL phenotypes in patients with myocardial infarction. Eur J Clin Invest. 2005;35:171-9. 2004 年 ・Shoji M, Sata M, Fukuda D, Tanaka K, Sato T, Iso Y, Shibata M, Suzuki H, Koba S, Geshi E, Katagiri T. Temporal and spatial characterization of cellular constituents during neointimal hyperplasia after vascular injury: Potential contribution of bone-marrow-derived progenitors to arterial remodeling. Cardiovasc Pathol. 2004;13:306-12. ・Tsunoda F, Koba S, Hirano T, Ban Y, Iso Y, Suzuki H, Geshi E, Katagiri T. Association between small dense low-density lipoprotein and postprandial accumulation of triglyceride-rich remnant-like particles in normotriglyceridemic patients with myocardial infarction. Circ J. 2004;68:1165-72. ・Shimizu N, Suzuki H, Wakabayashi K, Iso Y, Shibata M, Yorozuya M, Katagiri T, Takeyama Y. Expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in the pig coronary artery injury model: comparison of plain old balloon angioplasty and stent implantation. J Cardiol. 2004;43:131-9. 2003 年 ・Iso Y, Suzuki H, Sato T, Shoji M, Shibata M, Hamazaki Y, Koba S, Sakai T, Murakami M, Geshi E, Katagiri T. Contribution of monocyte chemoattractant protein-1 and c-fms/macrophage colony-stimulating factor receptor to coronary artery disease: analysis of human coronary atherectomy specimens J Cardiol. 2003;42:29-36. ・Koba S, Hirano T, Murayama S, Kotani T, Tsunoda F, Iso Y, Ban Y, Kondo T, Suzuki H, Katagiri T. Small dense LDL phenotype is associated with postprandial increases of large VLDL and remnant-like particles in patients with acute myocardial infarction. Atherosclerosis. 2003;170:131-40. ・Suzuki H, Murakami M, Shoji M, Iso Y, Kondo T, Shibata M, Ezumi H, Hamazaki Y, Koba S, Katagiri T. Hepatocyte growth factor and vascular endothelial growth factor in ischaemic heart disease. Coron Artery Dis. 2003;14:301-7. 2002 年 ・Yorozuya M, Suzuki H, Iso Y, Shibata M, Nakatani M, Koba S, Murakami M, Katagiri T, Takeyama Y. Comparison of the morphological changes of restenosis after the implantation of various types of stents in a swine model. Coron Artery Dis. 2002;13:305-12. ☆総説 ・Suzuki H, Iso Y. Clinical application of vascular regenerative therapy for peripheral artery disease. Biomed Res Int. 2014 Epub ahead of print ・Iso Y, Watanabe T, Shoji M, Suzuki H. Stem/progenitor cell-based approach for restenosis after percutaneous coronary intervention: Application of bone marrow progenitors and future perspective. Translational Medicine 2012 S7-001 ・Wakabayashi, K., Pakala, R., Watanabe, T., Mori, H., Iso Y. and Suzuki, H. Novel technologies and future perspectives of drug-eluting stent. Translational Medicine 2012 S7-002 ・Watanabe T, Sato K, Itoh F, Iso Y. Pathogenic involvement of heregulin-β(1) in anti-atherogenesis. Regul Pept. 2012;175:11-4. 5: Watanabe, T., Sato, K., Itoh, F., Iso Y., Nagashima, M., Hirano, T., and Shichiri, M. The roles of salusins in atherosclerosis and related cardiovascular diseases. J. Am. Soc. Hypertens. 2011;5:359-365. ・礒 良崇、嶽山陽一:狭心症の経過と予後因子.「冠動脈疾患(下)」日本臨床2011 年11月増刊号
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