氏名川島博人所属生化学教室職位教授学位博士 (薬学) 最終

Hoshi University
氏
名
川島
所
属
生化学教室
学
位
博士 (薬学)
最終学歴
教育活動
（担当授業科目）
研究活動
（研究テーマ）
博人
職
位
教授
東京大学大学院薬学系研究科博士課程
タンパク質と酵素、生物系実習 I
1. リンパ球体内動態と獲得免疫における糖鎖の機能解明
(1) 糖鎖合成酵素欠損マウスを用いた解析
(2) 新規抗糖鎖抗体を用いた解析
2. スギ花粉アレルゲン Cry j 1 の糖鎖修飾に着目した新規花粉症治療
法の開発
3. 糖鎖合成酵素欠損マウスを用いた炎症性腸疾患の発症機構の解明
4. 大腸ムチンの硫酸化による大腸発癌の抑制とその分子機構の解明
所属学会
American Society for Biochemistry and Molecular Biology (ASBMB)
Federation of American Societies for Experimental Biology (FASEB)
American Association of Immunologists (AAI)
Consortium for Functional Glycomics (CFG)
Society for Glycobiology
日本薬学会、日本生化学会、日本免疫学会、日本癌学会、
日本糖質学会、マクロファージ分子細胞生物学会
学内活動
（役職・委員等）
学外活動
（委員会委員等）
静岡県立大学薬学部客員教授
日本薬学会学術誌編集委員会委員
糖鎖科学中部拠点メンバー
Associate Member of the Faculty of 1000 (F1000) Biology
研究業績等
（受賞歴）
2001 年日本炎症・再生医学会奨励賞
2002 年上原生命科学財団リサーチフェローシップ
（主な著書・論文）
【著書】
1. Kawashima H. Generation of anti-sulfated glycan antibodies using sulfotransferase -deficient mice.
Methods in Molecular Biology, 1022:51-60, 2013.
2. Kawashima H. Roles of GlcNAc-6-O-sulfotransferases in lymphoid and nonlymphoid tissues.
Methods in Enzymology 479:243-256, 2010.
3. Kawashima H. Determination of chemokine-glycosaminoglycan interaction specificity.
Methods in Enzymology 416:254-263, 2006.
4. Kawashima H. Functions of glycans revealed by gene inactivation of L-selectin ligand sulfotransferases in mice.
Methods in Enzymology 416:279-290, 2006.
【論文】
1. Tsuboi K., Hirakawa J., Seki E., Imai Y., Yamaguchi Y., Fukuda M., and Kawashima H. Role of high
endothelial venule-expressed heparan sulfate in chemokine presentation and lymphocyte homing.
J. Immunol., 191:448-455, 2013.
2. Ohmichi Y., Hirakawa J., Imai Y., Fukuda M., and Kawashima H. Essential role of peripheral node addressin in
lymphocyte homing to nasal-associated lymphoid tissues and allergic immune responses.
J. Exp. Med., 208:1015-1025, 2011.
3. Hirakawa J., Tsuboi K., Sato K., Kobayashi M., Watan abe S., Takakura A., Imai Y., Ito Y., Fukuda M., and
Kawashima H. Novel anti-carbohydrate antibodies reveal the cooperative function of sulfated N- and O-glycans
in lymphocyte homing. J. Biol. Chem., 285:40864-40878, 2010.
4. Bao X., Moseman E.A., Saito H., Petryanik B., Thiriot A., Hatakeyama S., Ito Y., Kawashima H., Yamaguchi Y.,
Lowe J.B., von Andrian U.H., and Fukuda M. Endothelial heparan sulfate controls chemokine presentation in
recruitment of lymphocytes and dendritic cells to lymph nodes. Immunity, 33:817-829, 2010.
5. Tobisawa Y., Imai Y., Fukuda M., and Kawashima H. Sulfation of colonic mucins by
N-acetylglucosamine-6-O-sulfotransferase-2 and its protective function in experimental colitis in mice.
J. Biol. Chem., 285:6750-6760, 2010.
6. Kawashima H., Hirakawa J., Tobisawa Y., Fukuda M., and Saga Y.. Conditional gene targeting in mouse high
endothelial venules. J. Immunol., 182:5461-5468, 2009.
7. Mitoma J., Bao X., Petryanik B., Schaerli P., Gauguet J.M., Yu S.Y., Kawashima H., Saito H., Ohtsubo K., Marth
J.D., Khoo K.H., von Andrian U.H., Lowe J.B., and Fukuda M. Critical functions of N-glycans in
L-selectin-mediated lymphocyte homing and recruitment. Nature Immunology, 8:409-418, 2007.
8. Chen S., Kawashima H., Lowe J.B., Lanier L.L., and Fukuda M. Suppression of tumor formation in lymph nodes
by L-selectin-mediated natural killer cell recruitment. J. Exp. Med., 202:1679-1689, 2005.
9. Kawashima H., Petryniak B., Hiraoka N., Mitoma J., Huckaby V., Nakayama J., Uchimura K., Kadomatsu K.,
Muramatsu T., Lowe J.B., and Fukuda M. N-Acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively
control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules.
Nature Immunology 6:1096-1104, 2005.
10. Hiraoka N.*, Kawashima H.*, Petryniak B., Nakayama J., Mitoma J., Marth J.D., Lowe J.B., and Fukuda M.
Core 2 branching 1,6-N-acetylglucosaminyltransferase and high endothelial venule -restricted sulfotransferase
collaboratively control lymphocyte homing. J. Biol. Chem. 279:3058-3067, 2004. *equal contribution.
11. Kawashima H., Watanabe N., Hirose M., Sun X., Atarashi K., Kimura T., Shikata K., Matsuda M., Ogawa D.,
Heljasvaara R., Rehn M., Pihlajaniemi T., and Miyasaka M. Collagen XVIII, a basement membrane heparan
sulfate proteoglycan, interacts with L-selectin and monocyte chemoattractant protein -1.
J. Biol. Chem. 278:13069-13076, 2003.
12. Kawashima H., Atarashi K., Hirose M., Hirose J., Yamada S., Sugahara K., and Miyasaka M. Oversulfated
chondroitin/dermatan sulfates containing GlcA1/IdoA1-3GalNAc(4,6-O-disulfate) interact with L- and
P-selectin and chemokines. J. Biol. Chem. 277:12921-12930, 2002.
13. Hirose J., Kawashima H., Yoshie O., Tashiro K., and Miyasaka M. Versican interacts with chemokines and
modulates cellular responses. J. Biol. Chem. 276:5228-5234, 2001.
14. Kawashima H., Hirose M., Hirose J., Nagakubo D., Plaas H.K.A., and Miyasaka M. Binding of a large
chondroitin sulfate/dermatan sulfate proteoglycan, versican, to L -selectin, P-selectin, and CD44.
J. Biol. Chem. 275:35448-35456, 2000.
15. Kawashima H., Yamamoto K., Osawa T., and Irimura T. Purification and characterization of
UDP-GlcNAc:Gal1-4Glc(NAc)-1,3-N-acetylglucosaminyltransferase (poly-N-acetyllactosamine extension
enzyme) from calf serum. J. Biol. Chem. 268:27118-27126, 1993.
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