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Berardesca, E.: European Group for E$cacy Measurements on Cosmetics and Other Topical Products
(EEMCO): EEMCO guidance for the assessment of stratum corneum hydration: electrical methods. Skin Res.
Technol., 3: 126῎132, 1997.
Pierard, G. E.: EEMCO guidance for the assessment of
11)
12)
skin colour. J. Eur. Acad. Dermatol. Venereol., 10: 1῎11,
1998.
Pierard, G. E., the EEMCO Group: EEMCO guidance to
the in vivo assessment of tensile functional properties of
the skin: Part 1: Relevance to the structure and ageing of
the skin and subcutaneous tissues. Skin Pharmacol. Appl.
Skin Physiol., 12: 352῎362, 1999.
Parra, J. L., Paye, M., the EEMCO Group: EEMCO guidance for the in vivo assessment of skin surface pH. Skin
Pharmacol. Appl. Skin Physiol., 16: 188῎202, 2003.
Rogiers, V., the EEMCO Group: EEMCO guidance for
the assessment of the transepidermal water loss in cosmetic sciences. Skin Pharmacol. Appl. Skin Physiol., 14: 117῎
128, 2001.
Leveque, J. L.: EEMCO guidance for the assessment of
skin topography. J. Eur. Acad. Dermatol. Venereol., 12:
103῎114, 1999.
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1) s'_JKžt0“Ÿ g†(‚ ¡V¢£ ¤J“
¥ 28: 118῍128, 2004.
2) Grove, G. L., Grove, M. J., Leyden, J. J.: Optical Profilometry: An Objective Method for Quantification of Facial
Wrinkle. J. Am. Acad. Dermatol., 21: 631῍637, 1989.
3) u v wxyz w¦§{ |¨}g ~©ª
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4) f…†‡ ˆ‰®gŸ ()¯wV°)¡)54 3
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332
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5) !"#$%&'()*+,-#
#./012 345 29: 394῍405, 1996.
6) Jaspers, S., Hopermann, H., Sauermann, G., Hoppe, U.,
Lunderstat, R., Ennen, J.: Rapid in vivo measurement of
the topography of human skin by active image triangulation using a digital micromirror device. Skin Res. Tech-
7)
8)
nol., 5: 195῍207, 1999.
Jaspers, S., Bretschneider, T., Maerker, U., Ennen, J.: Optical topometry with PRIMOS: A powerful tool to prove
the e$cacy of skin care products in in-vivo studies. XXIst
IFSCC International Congress Proceedings, 430῍434, 2000.
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