ෘ↢ഭ⑼ቇ⎇ⓥ⾌ഥ㊄㧔ሶߤ߽ኅᐸ✚ว⎇ⓥᬺ㧕 ಽᜂ⎇ⓥႎ๔ᦠ ಽᜂ⺖㗴㧦ේ࿃ਇਇ⢒∝ߦኻߔࠆ⮎‛≮ᴺߩലᕈ⺞ᩏ ⎇ⓥಽᜂ⠪ ᧖ᶆ⌀ᑿ ฬฎደᏒ┙ᄢቇᄢቇ㒮කቇ⎇ⓥ⑼ᢎ ⎇ⓥදജ⠪ የፒᐽᒾ ฬฎደᏒ┙ᄢቇᄢቇ㒮කቇ⎇ⓥ⑼⻠Ꮷ ⎇ⓥදജ⠪ ർ᛬⃨ᄩ ฬฎደᏒ┙ᄢቇᄢቇ㒮කቇ⎇ⓥ⑼ഥᢎ ⎇ⓥදജ⠪ ㋈ᧁ⽵ᄦ ฬฎደᏒ┙ᄢቇᄢቇ㒮කቇ⎇ⓥ⑼⻠Ꮷ ⎇ⓥⷐᣦ ᆄߩᐕ㦂ޔᣢᓔᵹ↥߇ᰴ࿁ᵹ↥ߩ⁛┙ߒߚෂ㒾࿃ሶߢࠆߎߣ߇ࠄ߆ߦߥߞߚߒޕ ߆ߒ⸻ޔᢿᓟೋ࿁ᅧᆼߦ߅ߡ 40 ઍߢ߽ 58㧑߇↢ఽ₪ᓧߢ߈ߚޕ ᓟᣇⷞ⊛ᬌ⸛߆ࠄࠕࠬࡇࡦන⁛≮ࡦࡄࡋࡦࡇࠬࠕޔᴺ࠾࠼ࡊࡦࡇࠬࠕޔ ࠱ࡠࡦ≮ᴺ≮∉ޔᴺ≮࡞࠾ࡃࠪࡇޔᴺߩലᕈߪߥߎߣ߇ࠄ߆ߦߥߞߚޕ 㧭㧚⎇ⓥ⋡⊛ 㧯㧚⎇ⓥ⚿ᨐ ᣣᧄੱᅚᕈߩᅧᆼᐕ㦂ߪჇടߩ৻ㅜࠍߚߤߞߡ ᆄߩᐕ㦂ޔᣢᓔᵹ↥߇ᰴ࿁ᵹ↥ߩ⁛┙ߒߚෂ㒾 ߅ࠅޔ40 ઍߩਇᅧޔਇ⢒ᖚ⠪߇ỗჇߒߡࠆߎޕ ࿃ሶߢࠆߎߣ߇ࠄ߆ߦߥߞߚ⸻ޔߒ߆ߒޕᢿ ࠇࠄߩ 40 ઍਇ⢒∝ᖚ⠪ߩᰴ࿁ᅧᆼᚑഞ₸ࠍ⺑ ᓟೋ࿁ᅧᆼߦ߅ߡ 40 ઍߢ߽ 58㧑߇↢ఽ₪ᓧߒ ߔࠆߚޔฬฎደᏒ┙ᄢቇߦ߅ߡᅧᆼ▤ℂࠍߒ ߡࠆߎߣ߇ࠄ߆ߦߥߞߚޕ ߚᖚ⠪ߩ࠺࠲ࡌࠬࠍ↪ߡ⸘▚ᑼࠍ▚ߒߚޕ SAS ࠍ↪ߚࡠࠫࠬ࠹ࠖ࠶ࠢ⸃ᨆߦࠃߞߡࠕࠬ ߹ߚޔᄦࡦࡄ∉≮ᴺࠍઍߣߔࠆߐ߹ߑ߹ ࡇࡦන⁛≮ࡦࡄࡋࡦࡇࠬࠕޔᴺࡇࠬࠕޔ ߥᴦ≮ᴺ߇⹜ߺࠄࠇߡࠆ߇ޔේ࿃ਇߦኻߔࠆ ࡦࡊ࠼࠾࠱ࡠࡦ≮ᴺ≮∉ޔᴺ࠾ࡃࠪࡇޔ ⏕┙ߐࠇߚᴦ≮ᴺߪሽߒߥߢߎߘޕฦᴦ≮ᴺ ࡞≮ᴺߩലᕈߪߥߎߣ߇ࠄ߆ߦߥߞߚޕ ࠍ⮎‛ᛩਈߥߒ⟲ߣᲧセߒߡലᕈ߇ࠆ߆ߤ߁ ∉≮ᴺߪᗧᏅߪߥ߇ᚑഞ₸߇ૐะߦ ߆ࠍᓟᣇⷞ⊛ߦᬌ⸛ߒߚޕ ߞߚޕ ᰴ࿁↢ఽ₪ᓧ₸ ps⚥ޔⓍ↢ఽ₪ᓧ₸ pc ߪ 㧮㧚⎇ⓥᣇᴺ 1990 ᐕ߆ࠄ 2007 ᐕߦਇ⢒∝♖ᩏߩߚߦฬฎ ደᏒ┙ᄢቇࠍฃ⸻ߒߚᖚ⠪ߩ߁ߜࠄ߆ߥේ࿃ߢ ࠆሶችᄸᒻޔᄦᇚᨴ⦡⇣Ᏹޔ᛫ࡦ⢽⾰᛫ ∝⟲ࠍ㒰ߊේ࿃ਇ 1250 ⚵ߩᄦᇚߦߟߡ⺞ ᩏߒߚޕᆄߩᐕ㦂ޔᣢᓔᵹ↥࿁ᢙࡦࡇࠬࠕޔන ⁛≮ࡦࡄࡋࡦࡇࠬࠕޔᴺࡊࡦࡇࠬࠕޔ ࠼࠾࠱ࡠࡦ≮ᴺ≮∉ޔᴺ≮࡞࠾ࡃࠪࡇޔᴺ ࠍ⮎‛ᛩਈߥߒߣᲧセߒ⸃ࠢ࠶ࠖ࠹ࠬࠫࡠޔᨆࠍ logit(ps)=3.964-0.0652×(age)-0.408×(previous number of miscarriages) logit(pc)=6.806-0.1130×(age)-0.514×(previous number of miscarriages) ⸥ߩ⸘▚ᑼߢ⸘▚ߔࠆߎߣ߇ߢ߈ߚޕ ⴕߞߚ⎇ᧄޕⓥߪฬฎደᏒ┙ᄢቇ୶ℂᆔຬળߩᛚ ࠍᓧߚޕ 59 㧰㧚⠨ኤ ㆊߩ⎇ⓥ߆ࠄ߽ᅚᕈߩᐕ㦂ޔᣢᓔᵹ↥࿁ᢙ߇ ෂ㒾࿃ሶߢࠆߎߣߪႎ๔߇ߞߚ߇ߢ߇⏕ޔ ߈ߚޔߒ߆ߒޕ40 ઍߢ߽↥น⢻ߢࠅࠄ߈ޔ ࠆᔅⷐߪߥߣ߁ᖱႎឭଏ߇น⢻ߣߥߞߚޕ ᓥ᧪ߩႎ๔ߢ߽ࠄ߆ߥࠃ߁ߦේ࿃ਇਇ⢒∝ߦ ኻߔࠆ⮎‛ᛩਈߪലᕈߪߥߣ⠨߃ࠄࠇߚޕ ∉≮ᴺߦ⥋ߞߡߪᚑഞ₸߇ૐਅߔࠆะ߽ࠅޔ FDA ߇൘๔ߔࠆࠃ߁ߦᧄ㇌ߢ߽⎇ⓥ⋡⊛એᄖߢ ⴕࠊߥߎߣࠍផᅑߔࠆߴ߈ߢࠆޕ ᅚᕈߩട㦂߇ਇᅧ∝ޔᵹ↥ߩෂ㒾࿃ሶߢࠆߎߣ ߪ⏕ߢࠅޔᅚᕈߦኻߔࠆ⊒ߪ㊀ⷐߢࠆޕ E. ⚿⺰ ᆄߩᐕ㦂ޔᣢᓔᵹ↥߇ᰴ࿁ᵹ↥ߩ⁛┙ߒߚෂ㒾 ࿃ሶߢࠆߎߣ߇ࠄ߆ߦߥߞߚ⸻ޔߒ߆ߒޕᢿ ᓟೋ࿁ᅧᆼߦ߅ߡ 40 ઍߢ߽ 58㧑߇↢ఽ₪ᓧߢ ߈ߚޕ ᓟᣇⷞ⊛ᬌ⸛߆ࠄࠕࠬࡇࡦන⁛ࡦࡇࠬࠕޔ ࡋࡄࡦ≮ᴺ≮ࡦࡠ࠱࠾࠼ࡊࡦࡇࠬࠕޔᴺޔ ∉≮ᴺ≮࡞࠾ࡃࠪࡇޔᴺߩലᕈߪߥߎߣ ߇ࠄ߆ߦߥߞߚޕ 㧲 ஜᐽෂ㒾ᖱႎ ․ߦߥߒ 㧳㧚⎇ⓥ⊒ 1. ⺰ᢥ⊒ Sugiura-Ogasawara M, Ozaki Y, Kitaori T, Suzumori N, Obayashi S, Suzuki S. Live birth rate according to maternal age and previous number of recurrent miscarriages. Immunol 2009; 62: 314-319. 2. ቇળ⊒ ߥߒ 㧴㧚⍮⊛⽷↥ᮭߩ㗿⊓㍳⁁ᴫ 㧔੍ቯࠍޕ㧕 1. ․⸵ขᓧ 60 Am J Reprod 2. 3. ߥߒ ታ↪ᣂ᩺⊓㍳ ߥߒ ߘߩઁ ߥߒ ⎇ⓥᚑᨐߩೀⴕߦ㑐ߔࠆ৻ⷩ 㔀 ⊒⠪᳁ฬ ⺰ᢥ࠲ࠗ࠻࡞ฬ ⊒ฬ Ꮞภ ࡍࠫ ᐕ 5WIKWTC1ICUCYC TC/ 1\CMK; -KVCQTK6 5W\WOQTK0 1DC[CUJK5 .KXGDKTVJTCVG CEEQTFKPIVQOCVGTPCN#O , 4GRTQF +OOWPQN CIGCPFRTGXKQWU PWODGTQHTGEWTTGPV OKUECTTKCIGU 5W\WMK5 61
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