昭和大学薬学雑誌 第１巻 第 2 号 2010 年 原著論文㩷 睡眠改善薬に関する消費者の現状および販売時における㩷 薬剤師のかかわり㩷 㩷 ᧁޘሶ㧘ญஜ৻㧘᧻ᧄ⩿ޘ㧘ะᓟ㤗㉿㧘㥲⮮ ൟ㧘㩷 ⌀ਅ㗅৻㧘ᄢᶈ㧘ਃᶆධ⯥㧘⟤ሶ㧘ᚭㇱ ᢐ㩷 㩷 ᤘᄢቇ⮎ቇㇱ ␠ળ⮎ቇᢎቶ㧘⮎ቇᢎ⢒ផㅴࡦ࠲㩷 㩷 ⷐ ᣦ㩷 ޤ⊛⋡ޣ㧦↢ᵴ⠪ߦ߅ߌࠆਇ⌁ᤨߩኻᔕ㧘⌧⌁ᡷༀ⮎↪⚻㛎⠪ߩታᖱ㧘⌧⌁ᡷༀ⮎⾼ᤨߦ߅ߌ ࠆ⮎Ꮷ߳ߩᏗᦸࠍࠄ߆ߦߒ㧘⌧⌁ᡷༀ⮎⽼ᄁᤨߦ߅ߌࠆ⮎Ꮷߩኻᔕࠍᬌ⸛ߒߚ㧚㩷 ޣᣇᴺޤ 㧦⺞ᩏળ␠ࡕ࠾࠲߆ࠄㆬቯߒߚ᧲੩ㇺ㧘ᄹᎹ⋵㧘ජ⪲⋵߅ࠃ߮ၯ₹⋵ߦߔࠆ㪉㪇㨪 㪍㪐ᱦߩ↵ᅚ㪋㪇㪇ੱࠍኻ⽎ߣߒߡ㧘↢ᵴ⠪ߦ߅ߌࠆਇ⌁ᤨߩኻᔕࠍߪߓ⌧⌁ᡷༀ⮎ߦ㑐ߔࠆ 㪮㪼㪹 ߦࠃࠆࠕࡦࠤ࠻⺞ᩏࠍታᣉߒߚ㧚㩷 ⚿ޣᨐޤ 㧦ో࿁╵⠪ߩ߁ߜ㧘ਇ⌁ᤨߦࠕ࠼ࡃࠗࠬ߇ࠇ߫ฃ⸻ߔࠆੱߪ㪍㪌㪅㪊㧑ߛߞߚ㧚߹ߚ㧘ㅳߦ㪊 ࿁એ⌁ࠇߥੱߩਛߢ㧘කᏧࠍฃ⸻ߒߚੱߪ㪉㪋㪅㪈㧑ߢߞߚ㧚ኢߟ߈߇ᖡߣ߈ߦᏒ⽼ߩ⌧ ⌁ᡷༀ⮎ࠍ⾼ߒߥℂ↱ߪ㧘ߊߖߦߥࠆߣᔺ߆ࠄ㩿㪌㪈㪅㪎㧑㪀߇ᦨ߽ᄙ߆ߞߚ㧚⌧⌁ᡷༀ⮎⾼ ᤨߦ߅ߌࠆ⮎Ꮷ߳ߩᏗᦸߪ㧘 ߩ⮎ޟ↪ࠍᢎ߃ߡ߶ߒޠ㪍㪌㪅㪇㧑㧘⮎ࠍ㘶ࠎߛᓟߩᵈᗧὐߦ ߟߡᢎ߃ߡ߶ߒ㪌㪊㪅㪇㧑㧘⥄ಽߦߞߚ⮎ࠍㆬࠎߢ߶ߒ㪋㪐㪅㪇㧑ߥߤߩ࿁╵߇ࠍභߚ㧚 ⽼ᄁⅣႺߣߒߡߪ⮎ޟᏧߦ⋧⺣ߒߥ߇ࠄ⾼ߔࠆⅣႺࠍޠㆬࠎߛੱ߇㪌㪌㪅㪇㧑ߢߞߚ㧚㩷 ޤ⺰⚿ޣ 㧦⮎Ꮷߪ㧘ޟਇ⌁ߩ㗫ᐲ߿ᦼ㑆ࠍ⏕ߒ㧘ᔅⷐߦᔕߓߡฃ⸻൘ᅑࠍߔࠆ㧚 ޠ㧘ޟක≮↪ߩ⌧ ⌁⮎ߩࠗࡔࠫ߆ࠄ᧪ࠆㆊᐲߥਇࠍᛄߔࠆ㧚 ߇ߣߎޠᔅⷐߢࠆߣ⠨߃ࠄࠇߚ㧚ߐࠄߦ⮎ Ꮷߦߪ㧘∝⁁ߦวࠊߖߚ⮎ࠍㆬᛯߒ㧘↪߿↪ᓟߩᵈᗧὐߦߟߡᖱႎࠍឭଏߒߡߊߎ ߣ߇᳞ࠄࠇߡࠆߎߣ߇ࠊ߆ߞߚ㧚㩷 㩷 㪢㪼㫐㩷㪮㫆㫉㪻㫊㧦⌧⌁㓚ኂ㧘৻⥸↪ක⮎ຠ㧘⌧⌁ᡷༀ⮎㧘㫎㪼㪹 ⺞ᩏ㩷 㩷 ࡠ࡞ߐࠇߚߣߩႎ๔㪉㪀㧘⌧⌁ᤨ㑆߇㪍ᤨ㑆એਅߩ ✜ ⸒ ੱ߹ߚߪ㪐ᤨ㑆એߩੱߪ♧ዩ∛߅ࠃ߮⠴♧⢻⇣ ⌧⌁ߩᦨᄢߩᗧ⟵ߪᔃりߩ∋ഭ࿁ᓳ߇ᓧࠄࠇ Ᏹߩ∛₸߇㜞ߣߩႎ๔㪊㪀㧘ਇ⌁ߪ߁ߟ∛ߩ∝ ࠆߎߣߢࠅ㧘⌧⌁ਇ⿷ߦߥࠆߣోりୱᕃᗵ㧘ᵈ ⁁ߩ㪈ߟߢࠆߛߌߢߥߊ㧘ᘟᕈൻߒߚਇ⌁ߪ߁ ᗧ㓸ਛജߩૐਅ㧘ᜬਭജߩૐਅ߇↢ߓࠆ㧚ᦨㄭߢ ߟ∛ߩෂ㒾࿃ሶߢࠆߣ߁ႎ๔㪋㪀ߥߤ㧘ㆡᐲߥ ߪ㧘ᔀᄛ⁁ᘒߢߩㆇォⴕὑߪ㧘㘶㈬ㆇォߦ୯ߔࠆ ⌧⌁ࠍߣࠆߎߣߪ㧘↢ᵴߩ⾰㩿㪨㪦㪣㪀ࠍ㜞ࠆߛߌ ߣߩႎ๔ 㧘♧ዩ∛ᖚ⠪ߩ㪊㪎㧑߇ਇ⌁ࠍ૬⊒ߒߡ ߢߥߊ㧘↢ᵴ⠌ᘠ∛ߣߩ㑐ㅪ߽⸃ߐࠇߡ߈ߡ ߅ࠅ㧘ਇ⌁ࠍᡷༀߐߖߚ⚿ᨐ㧘♧ዩ∛߇ࠦࡦ࠻ ࠆ㧚ߎߩࠃ߁ߦ㧘⌧⌁ߪஜᐽࠍ⛽ᜬߔࠆߢ㕖Ᏹ 㪈㪀 ― 173 ― 昭和大学薬学雑誌 第１巻 第 2 号 2010 年 ߦ㊀ⷐߢࠆ㧚ߒ߆ߒߥ߇ࠄ㧘⚂㪉ഀߩੱ߇⌧⌁ ߣߒߚ㧚⺞ᩏળ␠ߪੱᖱႎߩขᛒࠍㆡಾߦⴕ ߢભ㙃߇ขࠇߡߥ߆ߚࠅ㧘ࠄ߆ߩਇ⌁߇ࠆ ߁ડᬺߣߒߡࡊࠗࡃࠪࡑࠢߩ↪ࠍ 㪌㪀 ߣߩႎ๔߿ 㧘ਇ⌁ߩ∛₸߇↵ᕈ㪈㪎㪅㪊㧑㧘ᅚᕈ 㪉㪈㪅㪌㧑ߣߩႎ๔߽ࠅ 㪍㪀㪃㪎㪀 㧘ࠊ߇࿖ߩ㪌ੱߦ㪈ੱ߇⌧ ࠄࠇߚቯᬺ⠪ࠍ↪ߒ㧘ඞฬൻߐࠇߚ⺞ᩏ⚿ ᨐࠍ⸃ᨆߒߚ㧚㩷 ⌁㗴ߢᖠࠎߢࠆߎߣ߇┍߃ࠆ㧚㩷 㩷 ߎߩࠃ߁ߥ⢛᥊ߩਛ㧘㪉㪇㪇㪊ᐕߦ⌧⌁ᡷༀ⮎ߣߒ 㧞㧚⺞ᩏ㗄⋡㩷 ߡႮ㉄ࠫࡈࠚࡦࡅ࠼ࡒࡦ㩿㪛㪧㪟㧦㪛㫀㫇㪿㪼㫅㪿㫐㪻㫉㪸㫄㫀㫅㪼㩷 㪟㫐㪻㫉㫆㪺㪿㫃㫆㫉㫀㪻㪼㪀㍤࡞ࠛ࠼ޟ㫤ޠ㩿ࠛࠬࠛࠬ⮎㪀߇ ⌁⚻㛎㧘ਇ⌁ᤨߩኻಣᣇᴺ㧘කᏧ߳ߩฃ⸻ߩน⢻ ⊒ᄁߐࠇߚ㧚㪛㪧㪟 ㍤ߪ㧘╙㪈ઍ᛫ࡅࠬ࠲ࡒࡦ⮎ ᕈ㧘⌧⌁ᡷༀ⮎⾼ߩน⢻ᕈ㧘⌧⌁ᡷༀ⮎⾼ᤨ ߣߒߡ㧘ᓥ᧪߆ࠄࠕ࡞ࠡᕈ∔ᖚߩᴦ≮ߦᐢߊ ߦ߅ߌࠆ⮎Ꮷ߳ߩᏗᦸ㧘⽼ᄁⅣႺ߳ߩᏗᦸߣߒ ↪ࠄࠇߡ߅ࠅ㧘৻⥸↪ක⮎ຠߣߒߡߪ㧘ߔߢߦ ߚ㧚㩷 ᛫ࠕ࡞ࠡ↪⮎ߣߒߡߛߌߢߥߊ㧘ਸ਼ࠅ‛㈮ 㩷 㒐ᱛ⮎ߣߒߡ߽㐳ߊ⽼ᄁߐࠇߡߚ㧚╙㪈ઍ᛫ ⺞ᩏ㗄⋡ߪ㧘ၮᧄዻᕈ㧘⌧⌁ߦ㑐ߔࠆ⍮⼂㧘ਇ 㧟㧚ಽᨆᣇᴺ㩷 ࡅࠬ࠲ࡒࡦ⮎ߪ㧘ㅢߩ㛽ᩰࠍᜬߞߡ߅ࠅ㧘⢽ṁ ߔߴߡߩ⚿ᨐߪ⸥ㅀ⛔⸘୯ߣߒߡߒߚ㧚ᐕઍ ᕈ߇㜞㧘ૐಽሶ㊂ߥߤߩℂ↱ߦࠃࠅ㧘ⴊᶧ⣖㑐 㑆ߦ߅ߌࠆࠅߩᬌቯߦߪ㧘ǿ 㪉 ᬌቯ㩿㪺㪿㫀㪄㫊㫈㫌㪸㫉㪼㩷 㐷ࠍㅢㆊߒ߿ߔ㧚ߎߩߚ㧘⣖ౝࡅࠬ࠲ࡒࡦࠍ 㫋㪼㫊㫋㪀 ࠍ ↪ ߚ 㧚 ಽ ᨆ ࠰ ࡈ ࠻ ߦ ߪ 㪪㪧㪪㪪㪈㪋㪅㪇㪡㩷 㪽㫆㫉㩷 ᛥߔࠆߎߣ߆ࠄ㎾㕒↪ࠍ␜ߒ㧘⌁᳇㧘ୱᕃᗵ㧘 㪮㫀㫅㪻㫆㫎㫊 ࠍ↪ߒߚ㧚㩷 ߹ߥߤߩ↪߇ᒝ㧚㪛㪧㪟 ㍤ߪߘߩ↪ ⚿ ᨐ ࠍ↪ߒߚ⌧⌁ᡷༀ⮎ߢࠆ㪏㪀㪃㪐㪀㧚㩷 ⌧⌁ᡷༀ⮎ߣߒߡߩ 㪛㪧㪟 ㍤ߪ㧘⽼ᄁ৻ࡩߢ ᐕ㑆⋡ᮡ㊄㗵ࠍ⽼ᄁߔࠆߥߤᕆㅦߦᏒ႐ߦᐢ߹ ߞߚ㧚ߒ߆ߒߥ߇ࠄ㧘৻⥸↪ක⮎ຠߣߒߡߩ 㪛㪧㪟 ㍤ࠍ↪ߔࠆน⢻ᕈߩࠆ↢ᵴ⠪ߩታᖱ߅ࠃ߮ ⽼ᄁⅣႺ߳ߩᏗᦸߥߤ㧘⁁ࠍ⺞ᩏߒߚႎ๔ߪ ᒰߚࠄߥ㧚㩷 ߘߎߢᧄ⎇ⓥߢߪ㧘↢ᵴ⠪ߦ߅ߌࠆਇ⌁ᤨߩኻ ᔕ㧘⌧⌁ᡷༀ⮎↪⚻㛎⠪ߩታᖱ㧘⌧⌁ᡷༀ⮎⾼ ᤨߦ߅ߌࠆ⮎Ꮷ߳ߩᏗᦸࠍࠄ߆ߦߒ㧘⌧⌁ ᡷༀ⮎⽼ᄁᤨߦ߅ߌࠆ⮎Ꮷߩኻᔕࠍᬌ⸛ߒߚ㧚㩷 ᣇ ᴺ 㧝㧚ኻ⽎⠪߅ࠃ߮ታᣉᤨᦼ㩷 ᧄ⎇ⓥߩኻ⽎⠪ߪ⺞ᩏળ␠ࡕ࠾࠲߆ࠄㆬቯ ߒߚ㧚ኻ⽎⠪ᢙߪ㪋㪇㪇ੱߣߒ㧘᧲੩ㇺ㧘ᄹᎹ⋵㧘 ජ⪲⋵㧘ၯ₹⋵ߩ㪉㪇ᱦ㨪㪍㪐ᱦ߹ߢߩᚑੱߢ㧘 ↵ᅚᲧ߅ࠃ߮ᐕ㦂᭴ᚑᲧߪ߶߷หᢙߦߥࠆࠃ߁ ㆬቯߒߚ㧚⺞ᩏߪ㪉㪇㪇㪎ᐕ㪋ߦታᣉߒߚ㧚߹ߚ㧘 หᬺ⠪ࠍឃ㒰ߔࠆ⋡⊛ߢ㧘ᧄੱ߇∛㒮߿⮎ዪ⮎ ᐫߦൕോߒߡࠆੱ㧘⮎ቇㇱߦ☋ߒߡࠆੱ㧘 ࿁╵⠪ߩዻᕈ㩷 㩷 㧝 ࿁╵⠪ߩዻᕈ㩷 㩷 ో㧔㫅㩷㪔㩷㪋㪇㪇㧕㩷 㩷 㫅㩷 㧑㩷 ᐕ㦂㩿ᱦ㪀㧖㩷 㩷 㩷 㪉㪇㨪㪉㪐㩷 㪎㪌㩷 㪈㪏㪅㪏㩷 㪊㪇㨪㪊㪐㩷 㪐㪍㩷 㪉㪋㪅㪇㩷 㪋㪇㨪㪋㪐㩷 㪎㪋㩷 㪈㪏㪅㪌㩷 㪌㪇㨪㪌㪐㩷 㪏㪊㩷 㪉㪇㪅㪏㩷 㪍㪇㨪㪍㪐㩷 㪎㪉㩷 㪈㪏㪅㪇㩷 ᕈ㧖㩷 㩷 㩷 ↵ᕈ㩷 㪉㪇㪌㩷 㪌㪈㪅㪊㩷 ᅚᕈ㩷 㪈㪐㪌㩷 㪋㪏㪅㪏㩷 ⡯ᬺ㩷 㩷 㩷 ળ␠ຬോຬ㧔▤ℂ⡯એᄖ㧕㩷 㪈㪉㪊㩷 㪊㪇㪅㪏㩷 ળ␠ຬോຬ㧔▤ℂ⡯㧕㩷 㪋㪊㩷 㪈㪇㪅㪏㩷 ක≮ᓥ⠪㩷 㪇㩷 㪇㪅㪇㩷 ળ␠ᓎຬ㩷 㪈㪇㩷 㪉㪅㪌㩷 ⥄༡ᬺ㩷 㪊㪈㩷 㪎㪅㪏㩷 ਥᇚ㩷 㪈㪈㪏㩷 㪉㪐㪅㪌㩷 ቇ↢㩷 㪈㪎㩷 㪋㪅㪊㩷 ή⡯㩷 㪉㪎㩷 㪍㪅㪏㩷 ߘߩઁߩൕੱ㩷 㪊㪈㩷 㪎㪅㪏㩷 㧖ᐔᚑ㪈㪐ᐕᐲ✚ോ⋭ੱญേᘒ⺞ᩏߣหߓഀวߢߞߚޕ㩷 㩷 ኅᣖ߇∛㒮߿⮎ዪ⮎ᐫߦൕോߒߡࠆੱ߅ࠃ߮ ኅᣖߦ⮎ቇㇱߦ☋ߔࠆቇ↢߇ࠆੱߪኻ⽎ᄖ ― 174 ― ࿁╵⠪㪋㪇㪇ੱߩၮᧄዻᕈߩౝ⸶ߪ㧘↵ᕈ㪌㪈㪅㪊㧑㧘 昭和大学薬学雑誌 第１巻 第 2 号 2010 年 ᅚᕈ㪋㪏㪅㪏㧑㧘㪉㪇ᱦઍ㪈㪏㪅㪏㧑㧘㪊㪇ᱦઍ㪉㪋㪅㪇㧑㧘㪋㪇ᱦઍ 㪈㪐㪅㪉㧑㧘㪊㪇ᱦઍ㪉㪋㪅㪉㧑㧘㪋㪇ᱦઍ㪈㪏㪅㪊㧑㧘㪌㪇ᱦઍ㪉㪇㪅㪏㧑㧘 㪈㪏㪅㪌㧑㧘㪌㪇ᱦઍ㪉㪇㪅㪏㧑㧘㪍㪇ᱦઍ㪈㪏㪅㪇㧑ߢߞߚ㩿 㪍㪇ᱦઍ㪈㪎㪅㪍㧑ߢࠅ㧘ᧄ⺞ᩏߦ߅ߌࠆ↵ᅚᲧ߅ࠃ 㧝㪀㧚ᐔᚑ㪈㪐ᐕᐲ✚ോ⋭ੱญേᘒ⺞ᩏߦࠃࠆߣ㧘᧲ ߮ᐕ㦂᭴ᚑᲧߣᗧߥᏅߪߥ߆ߞߚ㧚㩿↵ᅚᲧ㧦㫇 ੩ㇺ㧘ᄹᎹ⋵㧘ජ⪲⋵㧘ၯ₹⋵᳃ߩ㪉㪇㨪㪍㪐ᱦ 㧩㪇㪅㪐㪍㪐㧘ᐕ㦂᭴ᚑᲧ㧦㫇㧩㪇㪅㪐㪐㪐㪀㩷 ߹ߢߩ↵ᅚᲧߪ㪌㪇㪅㪈㪑㪋㪐㪅㪐㧘ᐕ㦂᭴ᚑᲧߪ㪉㪇ᱦઍ 㧞 ਇ⌁ߩ⚻㛎ߣߘߩኻᔕ 㩷 ਇ⌁ߩ⚻㛎ࠅ㩷 ߶ߣࠎߤᲤᣣࠆ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 ㅳߦ㧟㨪㧡࿁ࠆ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 ㅳߦ㧝㨪㧞࿁ࠆ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 ߦ㧝࿁⒟ᐲࠆ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 ߶ߣࠎߤߥ߇ޔ࿁߆⚻㛎ߒߚߎߣ߇ࠆ㩷 㩷 ోߊߥ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 ਇ⌁ࠍᡷༀߔࠆߚߦߒߚߎߣ㧔ⶄᢙ࿁╵น㧕㩷 ߽ߒߥ߆ߞߚ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 ㆇേࠍߒߚ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 Ꮢ⽼ߩ⌧⌁ᡷༀ⮎ࠍ↪ߒߚ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㘩↢ᵴࠍᡷༀߒߚ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 කᏧࠍฃ⸻ߒߚ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 ஜᐽ㘩ຠࠍ㘩ߴߚࠅߚߒࠅߛࠎߩޔ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 ੱߦ⋧⺣ߒߚ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 ṽᣇ⮎ࠍߩࠎߛ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 ⍮ੱ߆ࠄ⮎ࠍ߽ࠄߞߡ↪ߒߚ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 ⌧⌁ᡷༀ⮎એᄖߩᏒ⽼⮎ࠍ↪ߒߚ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 ࠞ࠙ࡦߦ⋧⺣ߒߚ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 ߡߪ߹ࠆ߽ߩߪ৻ߟ߽ߥ㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㩷 㨍 ో࿁╵⠪ᢙ㩷 㨏 ৻ᐲߢ߽ਇ⌁ࠍ⚻㛎ߒߚੱᢙ㩷 ో㧔㨚㧩㪋㪇㪇㪀㨍㩷 㨚㩷 㧑㩷 㪋㪎㩷 㪈㪈㪅㪏㩷 㪋㪇㩷 㪈㪇㪅㪇㩷 㪐㪉㩷 㪉㪊㪅㪇㩷 㪍㪉㩷 㪈㪌㪅㪌㩷 㪈㪊㪇㩷 㪊㪉㪅㪌㩷 㪉㪐㩷 㪎㪅㪊㩷 ో㧔㨚㧩㪊㪎㪈㪀㨏㩷 㨚㩷 㧑㩷 㪈㪍㪉㩷 㪋㪊㪅㪎㩷 㪈㪈㪍㩷 㪊㪈㪅㪊㩷 㪋㪊㩷 㪈㪈㪅㪍㩷 㪊㪐㩷 㪈㪇㪅㪌㩷 㪊㪍㩷 㪐㪅㪎㩷 㪊㪉㩷 㪏㪅㪍㩷 㪈㪐㩷 㪌㪅㪈㩷 㪈㪊㩷 㪊㪅㪌㩷 㪎㩷 㪈㪅㪐㩷 㪍㩷 㪈㪅㪍㩷 㪌㩷 㪈㪅㪊㩷 㪊㪎㩷 㪈㪇㪅㪇㩷 ో㧔㨚㧩㪋㪊㪀㨎㩷 㨚㩷 㧑㩷 㪐㩷 㪉㪇㪅㪐㩷 㪈㪉㩷 㪉㪎㪅㪐㩷 㪈㪊㩷 㪊㪇㪅㪉㩷 㪍㩷 㪈㪋㪅㪇㩷 㪊㩷 㪎㪅㪇㩷 㩷 㩷 ో㧔㨚㧩㪏㪎㪀㨐㩷 㨚㩷 㧑㩷 㪊㪇㩷 㪊㪋㪅㪌㩷 㪉㪐㩷 㪊㪊㪅㪊㩷 㪉㪈㩷 㪉㪋㪅㪈㩷 㪈㪊㩷 㪈㪋㪅㪐㩷 㪉㪈㩷 㪉㪋㪅㪈㩷 㪈㪉㩷 㪈㪊㪅㪏㩷 㪈㪇㩷 㪈㪈㪅㪌㩷 㪐㩷 㪈㪇㪅㪊㩷 㪊㩷 㪊㪅㪋㩷 㪉㩷 㪉㪅㪊㩷 㪋㩷 㪋㪅㪍㩷 㪋㩷 㪋㪅㪍㩷 㨎 Ꮢ⽼ߩ⌧⌁ᡷༀ⮎ࠍ↪ߒߚੱᢙ㩷 㨐 ㅳߦ㪊࿁એਇ⌁ࠍ⚻㛎ߒߚੱᢙ㩷 㩷 ਇ⌁ߦ㑐ߔࠆಽᨆ⚿ᨐ㩷 ߥ߇࿁߆⚻㛎ߒߚߎߣ߇ࠆੱߪ㪎㪅㪇㧑ߢ ⺞ᩏኻ⽎⠪ߩ߁ߜ㧘ਇ⌁߇߶ߣࠎߤᲤᣣࠆੱ ߞߚ㩿㧞㪀㧚⌧⌁ߩ⍮⼂ࠍ⺞ߴߚߣߎࠈ㧘 ޟᔃ⤳∛㧘 ߪ㧘ో࿁╵⠪ߩ㪈㪈㪅㪏㧑㧘ㅳߦ㪊㨪㪌࿁ࠆੱߪ㪈㪇㪅㪇㧑㧘 ⣖තਛ㧘♧ዩ∛ߥߤߩ↢ᵴ⠌ᘠ∛ߣ⌧⌁ߦ㑐ଥ ㅳߦ㪈㨪㪉࿁ࠆੱߪ㪉㪊㪅㪇㧑ߢߞߚ㩿㪉㪀㧚߹ߚ㧘 ࠆࠍߣߎ߁ߣޠ⍮ࠄߥ߆ߞߚੱ߇㪍㪏㪅㪇㧑ߢࠅ㧘 ৻ᐲߢ߽ਇ⌁⚻㛎ߩࠆੱߩ߁ߜਇ⌁ࠍᛴ߃ߡ ޟኢߟ߈߇ᖡߣ߈ߪ㧘↢ᵴࠍᄌ߃ࠆߣᡷༀߔࠆ ࠆੱߩ⌁ࠇߥߣ߈ߩኻಣᴺߣߒߡ㧘ޟ߽ߒ ߎ ߣ߇ ࠆࠍ ߣߎ߁ ߣ ޠ⍮ ࠄߥ߆ ߞߚ ੱߪ ߥ߆ߞߚ߇ޠ㪋㪊㪅㪎㧑ߢ㧘 ޟᏒ⽼ߩ⌧⌁ᡷༀ⮎ࠍ↪ 㪊㪋㪅㪏㧑㧘ޟኢߟ߈߇ᖡߎߣ߿⌁ࠅ߇ᵻߎߣߪ㧘 ߒߚߪੱࠆߩߣߎޠ㧘㪈㪈㪅㪍㧑ߢߞߚ㩿㪉㪀㧚ㅳ ᔃ߿ߩ∛᳇ߩࠨࠗࡦߢࠆߎߣ߇ࠆ߁ߣޠ ߦ㪊࿁એ⌁ࠇߥੱߩਛߢ߽ޟ߽ߒߥ߆ߞߚޠ ߎߣࠍ⍮ࠄߥ߆ߞߚੱߪ㪊㪊㪅㪊㧑ߢߞߚ㩿࿑㧝㪀㧚߹ 㪊㪋㪅㪌㧑㧘ޟᏒ⽼ߩ⌧⌁ᡷༀ⮎ࠍ↪ߒߚޠ㪉㪋㪅㪈㧑㧘 ߚ㧘⌁ࠇߥᤨߩฃ⸻ߩน⢻ᕈߪ㧘ߔߋߦฃ⸻ߔ ޟකᏧࠍฃ⸻ߒߚޠ㪉㪋㪅㪈㧑ߢߞߚ㧚⌧⌁ᡷༀ⮎ ࠆߣ߁ੱߪ㪋㪅㪌㧑㧘ࠕ࠼ࡃࠗࠬ߇ࠇ߫ฃ⸻ߔࠆ ↪⠪ߩౝ⸶ߪ㧘߶ߣࠎߤᲤᣣ⌁ࠇߥੱߪ㪉㪇㪅㪐㧑㧘 ߣ߁ੱߪ㪍㪌㪅㪊㧑ߢࠅ㧘ࠕ࠼ࡃࠗࠬ߇ߞߡ߽ ㅳߦ㪊㨪㪌࿁ࠆੱߪ㪉㪎㪅㪐㧑㧘ㅳߦ㪈㨪㪉㩷 ࿁ࠆੱߪ ฃ⸻ߒߥੱߪ㪊㪇㪅㪊㧑ߢߞߚ㩿࠺࠲⋭⇛㪀㧚㩷 㪊㪇㪅㪉㧑㧘ߦ㧝࿁⒟ᐲࠆੱߪ㪈㪋㪅㪇㧑㧘߶ߣࠎߤ ― 175 ― 昭和大学薬学雑誌 第１巻 第 2 号 2010 年 ࿑㧝 ⌧⌁ߦ㑐ߔࠆ⍮⼂㩷 㫅㧩㪋㪇㪇㩷 㨚㧩㩷 ࠕ࡞ࠦ࡞ߪ⌁⌧ޟᡷༀ⮎ߩޠઍࠊࠅߦߥࠆ 㪏㪐㪅㪊 㪈㪇㪅㪏 ⌧⌁ߪ㧤ᤨ㑆એߣࠄߥߌࠇ߫ߌߥ 㪏㪏㪅㪌 㪈㪈㪅㪌 㪏㪌㪅㪏 㪈㪋㪅㪊 ᄕ㘩ᓟߦࠦࡅ߿߅⨥ࠍ㘶ߣޔኢߟ߈߇⦟ߊࠆ 㪏㪈㪅㪏 Ꮢ⽼ߩ⌧⌁ᡷༀ⮎ߪᣣᏱ⊛ߦਇ⌁ߩੱߦㆡߒߡࠆ 㪈㪏㪅㪊 ኢߟ߈߇ᖡ⌁ࠅ߇ᵻߎߣߪ∛᳇ߩࠨࠗࡦߢࠆ 㪍㪍㪅㪏 㪊㪊㪅㪊 ኢߟ߈߇ᖡᤨߪ↢ᵴࠍᄌ߃ࠆߣᡷༀߔࠆߎߣ߇ࠆ 㪍㪌㪅㪊 㪊㪋㪅㪏 㪊㪉㪅㪇 ᔃ⤳∛ޔ⣖තਛ♧ޔዩ∛ߥߤ↢ᵴ⠌ᘠ∛ߣ⌧⌁ߦ㑐ଥ߇ࠆ 㪍㪏㪅㪇 㪏㪏㪅㪌 ߎߩਛߦߪ߭ߣߟ߽ߥ 㪇 㪈㪇 㪉㪇 䈲䈇 䈇䈇䈋 㪊㪇 㪋㪇 㪈㪈㪅㪌 㪌㪇 㪍㪇 㪎㪇 㪏㪇 㪐㪇 㩷 㩿㩼㪀㩷 㪈㪇㪇 㩿㧑㪀㩷 㩷 㩷 㩷 㩷 ࿑㧞 ኢߟ߈߇ᖡߣ߈ߦ⌧⌁ᡷༀ⮎ࠍ⾼ߔࠆน⢻ᕈ㩷 㫅㧩㪋㪇㪇㩷 㨚㧩㩷 㪈㪍㪅㪏 ⾼ߔࠆ ⾼ߒߥ 㪏㪊㪅㪊 㩷 㩿㩼㪀㩷 㩿㧑㪀㩷 㩷 ࿑㧟 Ꮢ⽼ߩ⌧⌁ᡷༀ⮎ࠍ⾼ߒߥℂ↱㧔ⶄᢙ࿁╵น㧕㩷 㫅㧩㪊㪊㪊㩷 㨚㧩㩷 㪌㪈㪅㪎 ߊߖߦߥࠆߣᔺ߆ࠄ ⥄ಽߦߞߡࠆ߆ࠄ߆ߥࠄ߆ࠊޔ 㪊㪉㪅㪈 ↪߇ߎࠊ߆ࠄ 㪊㪈㪅㪌 කᏧߦฃ⸻ߒߡ߆ࠄ⮎ߒߚ߆ࠄ 㪉㪈㪅㪐 㪈㪅㪉 ᔃࠍ∛ࠎߢࠆߣᕁࠊࠇࠆߩ߇ህߛ߆ࠄ ߘߩઁ 㪏㪅㪍 㩷 㪇 㪈㪇 㪉㪇 㪊㪇 㪋㪇 㪌㪇 㩿㩼㪀㩷 㪍㪇 㩿㧑㪀㩷 㩷 㩷 ― 176 ― 昭和大学薬学雑誌 第１巻 第 2 号 2010 年 㩷 ࿑㧠 ⾼⠪߆ࠄߩ⮎Ꮷ߳ߩᏗᦸ㧔ⶄᢙ࿁╵น㧕㩷 㩷 㨚㧩㩷 ⮎ߩ↪ࠍᢎ߃ߡ߶ߒ 㪍㪌㪅㪇 㫅㧩㪋㪇㪇㩷 ⮎ࠍ㘶ࠎߛᓟߩᵈᗧὐߦߟߡᢎ߃ߡ߶ߒ 㪌㪊㪅㪇 ⥄ಽߦߞߚ⮎ࠍㆬࠎߢ߶ߒ 㪋㪐㪅㪇 ⮎ߒߡߪߌߥੱߦߡߪ߹ࠄߥ߆ᢎ߃ߡ᰼ߒ 㪋㪉㪅㪇 ⮎ߩᣇࠍᢎ߃ߡ᰼ߒ 㪋㪇㪅㪌 කᏧߦฃ⸻ߔࠆ࠲ࠗࡒࡦࠣࠍᢎ߃ߡ᰼ߒ 㪈㪏㪅㪇 ↢ᵴᜰዉࠍߒߡ᰼ߒ 㪈㪊㪅㪌 කᏧߦฃ⸻ߔࠆ႐วޔක≮ᯏ㑐ࠍ⚫ߒߡ᰼ߒ 㪈㪉㪅㪊 ᖠߺߥߤߩ⋧⺣ߦߩߞߡ᰼ߒ 㪌㪅㪏 ․ߦ߽ߒߡ᰼ߒߊߥ 㪈㪇㪅㪇 ߎߩਛߦߡߪ߹ࠆ߽ߩߪ৻ߟ߽ߥ 㪌㪅㪌 㪇 㩷 㪈㪇 㪉㪇 㪊㪇 㪋㪇 㪌㪇 㪍㪇 㪎㪇 㩿㧑㪀㩷 㩷 㩷 㩷 㫅㧩㪋㪇㪇㩷 ࿑㧡 ⽼ᄁⅣႺ߳ߩᏗᦸ㧔ⶄᢙ࿁╵น㧕㩷 ⮎Ꮷ䈮⋧⺣䈚䈭䈏䉌⾼䈜䉎ⅣႺ 㨚㧩㩷 㪌㪌㪅㪇 䉦䉡䊮䉶䊥䊮䉫䉕䈉䈔䈭䈏䉌⾼䈜䉎ⅣႺ 㪊㪈㪅㪏 ⥄↱䈮⾼䈪䈐䉎ⅣႺ 㪉㪎㪅㪇 䊒䊤䉟䊋䉲䊷䈏䈢䉏䈢ⅣႺ 㪉㪇㪅㪇 㪈㪉㪅㪇 䈖䈱ਛ䈮䈅䈩䈲䉁䉎䉅䈱䈲৻䈧䉅䈭䈇 㩷 㪇 㪈㪇 㪉㪇 㪊㪇 㪋㪇 㪌㪇 㪍㪇 㩿㧑㪀㩷 㩷 㩷 ⌧⌁ᡷༀ⮎ߩ⾼ⅣႺߦ㑐ߔࠆಽᨆ⚿ᨐ㩷 㪋㪐㪅㪇㧑ߥߤߩ࿁╵߇ࠍභߚ㩿࿑㧠㪀㧚ߐࠄߦ㧘 ኢߟ߈߇ᖡߣ߈ߦᏒ⽼ߩ⌧⌁ᡷༀ⮎ࠍ⾼ ⽼ᄁⅣႺ߳ߩᏗᦸࠍ⾰ߒߚߣߎࠈ㧘⮎Ꮷߦ⋧ ߔࠆߣ࿁╵ߒߚੱߪ㧘㪈㪍㪅㪏㧑ߢ㧘⾼ߒߥߣ࿁ ⺣ߒߥ߇ࠄ⾼ߔࠆⅣႺࠍㆬࠎߛੱߪ㪌㪌㪅㪇㧑ࠍභ ╵ߒߚੱߪ㪏㪊㪅㪊㧑ߢߞߚ㩿࿑㧞㪀㧚Ꮢ⽼⮎ࠍ⾼ߒ 㧘ᰴߢࠞ࠙ࡦࡦࠣࠍฃߌߥ߇ࠄ⾼ߔࠆ ߥℂ↱ߣߒߡᄙ߆ߞߚ࿁╵ߪ㧘ߊߖߦߥࠆߣᔺ ⅣႺࠍㆬࠎߛੱ߇㪊㪈㪅㪏㧑㧘ࡊࠗࡃࠪ߇ߚࠇ ߆ࠄ㪌㪈㪅㪎㧑㧘⥄ಽߦߞߡࠆ߆ࠊ߆ࠄߥ߆ ߚⅣႺ߇㪉㪇㪅㪇㧑ߢߞߚ㩿࿑㧡㪀㧚㩷 ࠄ㪊㪉㪅㪈㧑㧘↪߇ߎࠊ߆ࠄ㪊㪈㪅㪌㧑ߢߞߚ㩿࿑ ⠨ ኤ 㧟㪀㧚㩷 ⌧⌁ᡷༀ⮎⾼ᤨߦ߅ߌࠆ⮎Ꮷ߳ߩᏗᦸࠍ ᧄ⎇ⓥߩ⚿ᨐ߆ࠄਇ⌁ࠍᛴ߃ߥ߇ࠄ㧘߽ߒߡ ㆬࠎߢ߽ࠄߞߚߣߎࠈ㧘⮎ߩ↪ࠍᢎ߃ߡ߶ߒ ߥੱ߇ࠆߎߣ㧘⌧⌁ߦ㑐ߔࠆ⍮⼂߇ਇ⿷ߒ 㪍㪌㪅㪇㧑㧘⮎ࠍ㘶ࠎߛᓟߩᵈᗧὐߦߟߡᢎ߃ߡ ߡࠆߎߣ߇␜ໂߐࠇ㧘ਇ⌁ߢᖠࠎߢࠆੱߦኻ ߶ߒ㪌㪊㪅㪇㧑㧘⥄ಽߦߞߚ⮎ࠍㆬࠎߢ߶ߒ ߒߡ㧘⌧⌁ࠍᡷༀߔࠆߎߣߩ↪ᕈ߿⌧⌁ࠍᡷༀ ― 177 ― 昭和大学薬学雑誌 第１巻 第 2 号 2010 年 ߔࠆᣇᴺࠍࠕ࠼ࡃࠗࠬߔࠆߥߤߩࠕࡊࡠ࠴߇ ߢߪ㧘৻⥸↪ක⮎ຠߩ↪ࠍ⍮ࠅߚߣ࿁╵ߒ ᔅⷐߣ⠨߃ࠄࠇߚ㧚㩷 ߚੱߪ㪉㪊㪅㪐㧑ߢߞߚ㪈㪌㪀㧚㪉㪇㪇㪉ᐕߦᴰỈࠄ߇ⴕߞ ࿖㓙∔∛ಽ㘃ߢࠆ 㪠㪚㪛㪄㪈㪇ߢߪ ޟਇ⌁∝ߣߪ⌧ ߚ⺞ᩏႎ๔ߢ߽㧘↪ࠍ⺑ߒߡ߶ߒੱߪ ⌁㓚ኂߩ⸷߃߇ዋߥߊߣ߽ㅳ㪊࿁એߢ㧘㪈ࡩએ 㪉㪊㧑ߢࠅᧄ⎇ⓥߩ⚿ᨐࠃࠅዋߥ߆ߞߚ㪈㪍㪀㧚ߎࠇ ᜬ⛯ߔࠆ߽ߩࠅ߅ߡߒߣޠ㧘ߎࠇߦᒰߡߪ߹ࠆ ࠄߩ߫ࠄߟ߈ߪ㧘ኻ⽎⠪ߩ㆑ߥߤ߽ࠆ߇㧘৻ ੱߪฃ⸻൘ᅑߩኻ⽎ߣߥࠆ㧚ᧄ⎇ⓥߢߪਇ⌁∝⁁ ⥸↪ක⮎ຠߩ↪ࠍ⺑ߒߡ߶ߒߣᕁߞߡ ߇⛯ߡࠆᦼ㑆߹ߢ⾰ߒߡߥ߇㧘৻ㇱߩ ࠆੱ߇ᦨㄭჇ߃ߡࠆߣ߽⠨߃ࠄࠇࠆ㧚ߐࠄߦ㧘 ↪⠪ߪ⌧⌁ᡷༀ⮎ߩㆡᔕએᄖߩੱߢࠆน⢻ ᧄ⎇ⓥߢߩ⮎ޟ↪ࠍᢎ߃ߡ߶ߒߦޠᰴߢ ᕈ߇⠨߃ࠄࠇߚ㧚߹ߚ㧘කᏧ߳ߩฃ⸻ߩน⢻ᕈߦ ᄙ߆ߞߚߩ߇ࠍ⮎ޟ㘶ࠎߛᓟߩᵈᗧὐߦߟߡᢎ ߟߡߪ㧘߫ࠇ߇ࠬࠗࡃ࠼ࠕޟฃ⸻ߔࠆߣޠ ߃ߡ߶ߒޠ㪌㪊㪅㪇㧑㧘 ⥄ޟಽߦวߞߚ⮎ࠍㆬࠎߢ߶ ߁ੱ߇ᄙ߆ߞߚ㧚ߎࠇࠄߩߎߣ߆ࠄ㧘ਇ⌁ࠍ⸷߃ ߒޠ㪋㪐㪅㪇㧑ߢߞߚߎߣ߆ࠄ㧘⮎Ꮷߦߪ∝⁁ ࠆੱ߿⌧⌁ᡷༀ⮎⾼Ꮧᦸ⠪ߦኻߒ㧘ਇ⌁ߩ㗫ᐲ ߦวࠊߖߚ⮎ࠍㆬᛯߒ㧘↪߿↪ᓟߩᵈᗧὐ ߿ᦼ㑆ࠍ⏕ߒ㧘ᔅⷐߦᔕߓߡฃ⸻൘ᅑࠍߔࠆߥ ߦ㑐ߔࠆᖱႎࠍឭଏߒߡߊߎߣ߇᳞ࠄࠇߡ ߤߩኻᔕ߇ᔅⷐߢࠆߣᕁࠊࠇߚ㧚㩷 ࠆߎߣ߇ࠊ߆ߞߚ㧚㩷 ⌧⌁ᡷༀ⮎ࠍ⾼ߔࠆⅣႺ߳ߩᏗᦸߪ㧘⮎ޟ ਇ⌁ᤨߦ⌧⌁ᡷༀ⮎ࠍ⾼ߒߥℂ↱ߪ㧘ߊޟ ߖߦߥࠆߣᔺ߆ࠄ߽ᦨ߇ޠᄙ߆ߞߚ㧚ࠛࠬࠛࠬ Ꮷߦ⋧⺣ߒߥ߇ࠄ⾼ߔࠆⅣႺ߽ᦨ߇ޠᄙ߆ߞߚ㧚 ⮎߇㪉㪇㪇㪉ᐕߦⴕߞߚࠗࡦ࠲ࡀ࠶࠻⺞ᩏߢߪ㧘 㪉㪇㪇㪋ᐕߦ㊀ࠄ߇ⴕߞߚ⺞ᩏߦ߅ߡ㧘⥄Ꮖ⽿છ ⌁⌧ޟዉ⮎ߦኻߔࠆਇߢ߆ߥߩޠ㧘 ޟଐሽ∝ߦ 㪈㪇㪀 ߦࠃࠆ࡞ࡈࡔ࠺ࠖࠤ࡚ࠪࡦߦߟߡ⾰ߒ ߥࠅߘ߁߇ޠ㪎㪋㪅㪏㧑ߣᦨ߽ᄙߊ 㧘ᧄ⎇ⓥߩഀว ߚߣߎࠈ㧘ᶖ⾌⠪ߩ㪏㪋㪅㪇㧑߇ޟකᏧ߿⮎Ꮷߦ⋧ ࠃࠅ㜞⚿ᨐ߇ߡࠆ㧚߹ߚ㧘ࠄ߇ⴕߞߚ ⺣ߔࠆߚ߃╵ߣޠ㪈㪎㪀㧚߹ߚ㧘╩⠪ࠄ߇㪉㪇㪇㪍ᐕߦታ ⌧⌁⮎ߦ㑐ߔࠆ⺞ᩏߢߪ㧘ᄙߊߩ↢ᵴ⠪߇ߦ≻ޟ ᣉߒߚ⺞ᩏߢߪ㧘߆ߗ⮎ࠍ⾼ߔࠆ㓙ߦ߽㪍ഀߩ ߥࠆޟޠෂ㒾ߥ⮎ࠍࠫࡔࠗ߁ߣޠᜬߞߡࠆ ߣႎ๔ߒߡࠆ㪈㪈㪀㧚ߐࠄߦ㧘㨬࠼ࠛ࡞㫤㨭⽼ᄁ⋥ ੱ߇⮎Ꮷߦ⋧⺣ߔࠆⅣႺࠍᦸࠎߢߚ㪈㪏㪀㧚ߎࠇ ᓟ߆ࠄਛᲥࡦ࠲߳ߩวࠊߖ߇ᕆჇߒߡ ߒߥ߇ࠄක⮎ຠࠍ↪ߔࠆߎߣࠍᦸࠎߢࠆߣ ⌁⌧ޟᡷༀ⮎ࠍޠ⮎⌁⌧ޟߣޠ ࠆߎߣ߆ࠄ߽㪈㪉㪀㧘 ߁ߎߣ߇␜ໂߐࠇߚ㧚㪛㪧㪟 ㍤ߪ㧘⌁ẜᤨࠍ⍴ ᷙหߒ㧘ක≮↪ක⮎ຠߩ⌧⌁⮎ߩଐሽᕈߩࠗࡔ ❗ߒ✚⌧⌁ᤨ㑆ࠍᑧ㐳ߔࠆߥߤߩႎ๔߇ࠅ㪈㪐㪀㧘 ࠄߩ⚿ᨐ߆ࠄ㧘ඨᢙએߩᶖ⾌⠪߇⮎Ꮷߦ⋧⺣ ࠫ߇ᒝߊᱷߞߡࠆߎߣ߇⠨߃ࠄࠇߚ㧚ࠕࡔࠞ㧘 ޟኢߟ߈߇ᖡ㨭߇ࠅ⌁ޟᵻߥ⊛ᤨ৻ߩߤߥޠ ࠗࠡࠬ㧘࠼ࠗ࠷ߥߤߢ৻⥸↪ක⮎ຠߣߒߡߩ⽼ ⌁㓚ኂߣᾫ⌁㓚ኂߦㆡߒߚ⮎ߢࠆ㧚㪌㪇㫄㪾 ࠍ㪈ᣣ㪉 ᄁታ❣߇ࠆਛߢ㧘㪛㪧㪟 ㍤ߩଐሽᕈߦߟߡߪ㧘 ࿁ߢᲤᣣ↪ߔࠆߣ㪋ᣣ⋡એ㒠ߦߪࡊࡏߣห ઁߩ∔ᖚࠍ૬⊒ߒߡࠆੱ߿૬↪⮎߇ࠆੱߦ ╬ߩലᨐߣߥߞߚߣߩႎ๔߽ࠅ㧘㪉㨪㪊࿁↪ߒ 㪈㪊㪀 ኻߔࠆᢙઙߩ∝ႎ๔߇ߐࠇߡࠆ⒟ᐲߢࠆ 㧚 ߡ߽∝⁁߇ࠃߊߥࠄߥ႐วߪකᏧߪ⮎Ꮷ ਇ⌁ࠍ⸷߃ࠆੱߦኻߒ㧘ක≮↪ߩ⌧⌁⮎ߩࠗࡔ ╬ߦ⋧⺣ߔࠆߎߣ߇ᦸ߹ߒ㪉㪇㪀㧚߹ߚ㧘↢ᵴ⠌ᘠ ࠫ߆ࠄߊࠆㆊᐲߥਇࠍᛄߔࠆߎߣ߽ᔅⷐߣ ∛ട≮ਛߩ⌧⌁ᡷༀ⮎↪⚻㛎⠪㪈㪇ੱਛ㪋ੱ߇ᤤ ⠨߃ࠄࠇߚ㧚㩷 㑆ߩ⌁᳇߇ᒝ߆ߞߚߣ╵߃ߡࠆႎ๔߽ࠆ㪉㪈㪀㧚 ߹ߚ㧘ᧄ⎇ⓥߢ⌧⌁ᡷༀ⮎ࠍ⾼ᤨߦ߅ߌࠆ⮎ ⮎Ꮷߪ㧘ਇ⌁ࠍ⸷߃ࠆੱ߿⌧⌁ᡷༀ⮎⾼Ꮧᦸ Ꮷ߳ߩᏗᦸߪ㧘ߩ⮎ޟ↪ࠍᢎ߃ߡ߶ߒޠ ⠪ߦኻߒ㧘ࠛࡆ࠺ࡦࠬࠍ↢߆ߒߥ߇ࠄⓍᭂ⊛ߦ ߇㪍㪌㪅㪇㧑ߢᦨ߽ᄙ߆ߞߚ㧚㪉㪇㪇㪌ᐕߦ⊕ࠄ߇ⴕߞ ߈߆ߌߡߊߎߣ߇ᦸ߹ࠇࠆ㧚㩷 ߚ⺞ᩏߢ߽㧘৻⥸↪ක⮎ຠߩ↪ߦߟߡ⺑ ᧄ⺞ᩏߪ⺞ᩏળ␠ࡕ࠾࠲߆ࠄኻ⽎⠪ࠍㆬ ࠍฃߌߚੱߪ㪍㪐㪅㪉㧑ߢࠅ㧘 ޟല⢻ലᨐߦߟ ߒ㧘ࠗࡦ࠲ࡀ࠶࠻ࠍ↪ߡ࿁╵ࠍᓧߡࠆ㧚ᧄ 㪈㪋㪀 ߡޠ㪍㪐㪅㪎㧑ߦߟߢᄙ߆ߞߚ 㧚৻ᣇ㧘㪉㪇㪇㪊ᐕߩ ᄙߪࠗࡦ࠲ࡀ࠶࠻⺞ᩏ࿁╵⠪ߩᗧ⼂ߩ․ᓽࠍ㧘 ᄢⴐ⮎Ꮏᬺදળ߇ⴕߞߚ╙㪉㪎࿁ᶖ⾌⠪ᗧ⼂⺞ᩏ ㇷㅍ⺞ᩏ߿⸰⺞ᩏߣߞߚᓥ᧪ဳ⺞ᩏߣᲧߴ ― 178 ― 昭和大学薬学雑誌 第１巻 第 2 号 2010 年 ߡ㧘⚳り㓹↪㧘ᐕഞ⾓㊄ߥߤߩᣣᧄဳ㓹↪ᘠⴕ߳ 㪻㫀㪸㪹㪼㫋㪼㫊㩷㫄㪼㫃㫃㫀㫋㫌㫊㩷㪸㫅㪻㩷㫀㫄㫇㪸㫀㫉㪼㪻㩷㪾㫃㫌㪺㫆㫊㪼㩷㫋㫆㫃㪼㫉㪸㫅㪺㪼㧘 ߩ⹏ଔ߇ૐ㧘↢ᵴߦߟߡߩḩ⿷ᐲ߇ૐ㧘␠ 㪘㫉㪺㪿㩷㪠㫅㫋㪼㫉㫅㩷㪤㪼㪻㧘㪈㪍㪌㧘㪏㪍㪊㪄㪏㪍㪎㩷㩿㪉㪇㪇㪌㪀㪅㩷 ળߦਇᐔࠍᗵߓߡࠆੱ߇ᄙ㧘ஜᐽ㧘㧘 㪋㪀㩷 㪛㫀㪼㫋㪼㫉㩷 㪩㫀㪼㫄㪸㫅㫅㪃㩷 㪬㫃㫉㫀㪺㪿㩷 㪭㫆㪻㪼㫉㪿㫆㫃㫑㪼㫉㧦㪧㫉㫀㫄㪸㫉㫐㩷 ⠧ᓟ↢ᵴߦኻߔࠆਇᗵ߇ᒝ㧘↢ᵴߦలታᗵࠍ 㫀㫅㫊㫆㫄㫅㫀㪸㪑㩷㪸㩷㫉㫀㫊㫂㩷㪽㪸㪺㫋㫆㫉㩷㫋㫆㩷㪻㪼㫍㪼㫃㫆㫇㩷㪻㪼㫇㫉㪼㫊㫊㫀㫆㫅㪖㧘 㩷 ᗵߓߡࠆੱ߇ዋߥߎߣࠍᜰ៰ߒߡࠆ㧚৻ᣇ㧘 㪡㫆㫌㫉㫅㪸㫃㩷㫆㪽㩷㪘㪽㪽㪼㪺㫋㫀㫍㪼㩷㪛㫀㫊㫆㫉㪻㪼㫉㫊㧘㩷 㪎㪍㩷 㧘㪉㪌㪌㵨㪉㪌㪐㩷 ㇷㅍ⺞ᩏߪ࿁₸߇ૐ㧘⺞ᩏ࠹ࡑߦ㑐ᔃ߇ 㩿㪉㪇㪇㪊㪀㩷 ࠆੱ߇╵߃߿ߔߎߣ㧘⸰⺞ᩏ߿㔚⺞ᩏߥߤ 㪌㪀㩷 ⽷࿅ᴺੱஜᐽജߠߊࠅᬺ⽷࿅㪅㩷 ⽷࿅ᴺ 㪉㪉㪀 ߦ߽㗴ὐ߇ࠆߎߣ߽ᜰ៰ߒߡࠆ 㧚࡞ࡈ ੱஜᐽ㨯ജߠߊࠅᬺ⽷࿅㩷 ஜᐽߠߊࠅߦ ࡔ࠺ࠖࠤ࡚ࠪࡦ߇ផㅴߐߡࠆᧄ㇌ߦ߅ߡ㧘 㑐ߔࠆᗧ⼂⺞ᩏႎ๔ᦠ㩷 㪈㪐㪐㪎㩷 Ꮢ⽼ߩ⌧⌁ᡷༀ⮎ߦ㑐ߔࠆታᘒ⺞ᩏߪዋߥ㧚ᕆ 㪍㪀㩷 㪛㫆㫀㩷 㪰㪃㩷 㪤㫀㫅㫆㫎㪸㩷 㪤㪃㩷 㪬㪺㪿㫀㫐㪸㫄㪸㩷 㪤㪅㩷 㪧㫉㪼㫍㪸㫃㪼㫅㪺㪼㩷 㫆㪽㩷 ㅦߦ↪ⅣႺ߇ᐢ߇ߞߡࠆߎߣ߇੍᷹ߐࠇࠆ 㫊㫃㪼㪼㫇㩷㪻㫀㫊㫋㫌㫉㪹㪸㫅㪺㪼㩷㪸㫅㪻㩷㪿㫐㫇㫅㫆㫋㫀㪺㩷㫄㪼㪻㫀㪺㪸㫋㫀㫆㫅㩷㫌㫊㪼㩷㫀㫅㩷 ߎߣ߆ࠄ㧘ᓟ㧘ᧄ⎇ⓥߣߪ⇣ߥߞߚᲣ㓸࿅ࠍኻ 㫉㪼㫃㪸㫋㫀㫆㫅㩷 㫋㫆㩷 㫊㫆㪺㫀㫆㪻㪼㫄㫆㪾㫉㪸㫇㪿㫀㪺㩷 㪽㪸㪺㫋㫆㫉㩷 㫀㫅㩷 㫋㪿㪼㩷 ⽎ߣߒߚ⺞ᩏ߇ታᣉߐࠇ㧘Ꮢ⽼ߩ⌧⌁ᡷༀ⮎ߦ㑐 㪾㪼㫅㪼㫉㪸㫃㩷 㪡㪸㫇㪸㫅㪼㫊㪼㩷 㪸㪻㫌㫃㫋㩷 㫇㫆㫇㫌㫃㪸㫋㫀㫆㫅㪅㩷 㪡㩷 㪜㫇㫀㪻㪼㫄㫀㫃㪃㩷 ߔࠆታᘒࠍࠄ߆ߦߔࠆᔅⷐ߇ࠆߣᕁࠊࠇࠆ㧚㩷 㪈㪇㪃㩷㪎㪐㪄㪏㪍㩷㩿㪉㪇㪇㪇㪀㩷 㪎㪀㩷 㪛㫆㫀㩷㪰㪃㩷㪤㫀㫅㫆㫎㪸㩷㪤㪃㩷㪬㪺㪿㫀㫐㪸㫄㪸㩷㪤㪅㩷㪪㫃㪼㪼㫇㪄㫄㪼㪻㫀㪺㪸㫋㫀㫆㫅㩷 ⚿ ⺰ 㪽㫆㫉㩷㫊㫐㫄㫇㫋㫆㫄㪸㫋㫀㪺㩷㫀㫅㫊㫆㫄㫅㫀㪸㩷㫀㫅㩷㫋㪿㪼㩷㪾㪼㫅㪼㫉㪸㫃㩷㫇㫆㫇㫌㫃㪸㫋㫀㫆㫅㩷 ᧄ⎇ⓥߩ⚿ᨐ㧘⮎Ꮷߪ㧘ਇ⌁ࠍ⸷߃ࠆੱ߿⌧ 㫆㪽㩷㪡㪸㫇㪸㫅㪅㩷㪪㫃㪼㪼㫇㩷㪸㫅㪻㩷㪙㫀㫆㫃㫆㪾㫀㪺㪸㫃㩷㫉㪿㫐㫋㪿㫄㫊㪃㩷㪊㪃㩷㪈㪋㪐㪄㪌㪎㩷 㩿㪉㪇㪇㪌㪀㩷 ⌁ᡷༀ⮎⾼Ꮧᦸ⠪ߦኻߒ㧘ࠍ⌁⌧ޟᡷༀߔࠆߎ ߣߩ↪ᕈ߿⌧⌁ࠍᡷༀߔࠆᣇᴺࠍࠕ࠼ࡃࠗࠬ 㪏㪀㩷 㪠㫋㫆㪿㩷 㪟㪅㩷 㪦㫅㪄㫋㪿㪼㪄㫄㪸㫉㫂㪼㫋㩷 㫊㫃㪼㪼㫇㪄㪼㫅㪿㪸㫅㪺㫀㫅㪾㩷 㪻㫉㫌㪾㫊㩷 ߔࠆߥߤߩࠕࡊࡠ࠴ࠍߔࠆ㧚ޠ㧘ޟਇ⌁ߩ㗫ᐲ߿ 㩿㪥㫆㫅㫇㫉㪼㫊㪺㫉㫀㫇㫋㫀㫆㫅㩷 㪟㫐㫇㫅㫆㫋㫀㪺㫊㪀㪅㩷 㪚㫃㫀㫅㫀㪺㪸㫃㩷 㪧㫉㪸㪺㫋㫀㪺㪼㪃㩷 ᦼ㑆ࠍ⏕ߒ㧘ᔅⷐߦᔕߓߡฃ⸻൘ᅑࠍߔࠆ㧚ޠ㧘 㪉㪋㪃㩷㪏㪍㪐㪄㪎㪉㩷㩿㪉㪇㪇㪌㪀㩷 ޟක≮↪ߩ⌧⌁⮎ߩࠗࡔࠫ߆ࠄ᧪ࠆㆊᐲߥਇ 㪐㪀㩷 㪦㫆㪿㪸㫊㪿㫀㩷㪫㪅㩷㪘㫅㫋㫀㪿㫀㫊㫋㪸㫄㫀㫅㪼㩷㪸㪾㪼㫅㫋㫊㩷㪩㪼㫍㫀㪼㫎㧘㥦ࠕ ࡞ࠡࡈࡠࡦ࠹ࠖ㪃㩷㪍㪃㩷㪊㪍㪄㪋㪇㩷㩿㪉㪇㪇㪍㪀㩷 㩷 ࠍᛄߔࠆ㧚߇ߣߎޠᔅⷐߢࠆߣ⠨߃ࠄࠇߚ㧚 ߐࠄߦ⮎Ꮷߦߪ㧘∝⁁ߦวࠊߖߚ⮎ࠍㆬᛯߒ㧘 㪈㪇㪀㩷 ਇ⌁⊕ᦠ㧙࠺࠲ߢࠆਇ⌁ߩታᘒ㧙㪃㩷 ࠛࠬ ࠛࠬ⮎㩷 ↪߿↪ᓟߩᵈᗧὐߦߟߡᖱႎࠍឭଏߒ ߡߊߎߣ߇᳞ࠄࠇߡࠆߎߣ߇ࠊ߆ߞߚ㧚⮎ 㪈㪈㪀㩷 㪢㪸㫄㪼㫀㩷㪤㪃㩷㪪㪿㫀㫄㫀㫑㫌㩷㪠㪃㩷㪢㫆㫀㫅㫌㫄㪸㩷㪤㪃㩷㪼㫋㩷㪸㫃㪅㩷 ᖚ⠪ ߮ᶖ⾌⠪ߦ߅ߌࠆ⌧⌁⮎ߦኻߔࠆࠗࡔࠫ㪅㩷 Ꮷ߆ࠄߩⓍᭂ⊛ߥ߈߆ߌ߇ᦸ߹ࠇࠆ㧚㩷 ╙㪋࿁ᣣᧄ࡞ࡈࡔ࠺ࠖࠤ࡚ࠪࡦቇળ㩷 ⻢ ㄉ 㪈㪉㪀㩷 㪪㫌㪾㫀㪿㪸㫉㪸㩷㪢㪃㩷㪥㫀㫊㪿㫀㫆㩷㪪㪃㩷㪤㪸㪻㫆㫅㫆㩷㪢㪃㩷㪼㫋㩷㪸㫃㪅㩷 Ⴎ㉄ࠫ ࡈࠚࡦࡅ࠼ࡒࡦࠍਥ⮎ߣߔࠆ⌁㎾㕒 ᧄ⎇ⓥߪ㧘⽷࿅ᴺੱ㩷 ৻⥸↪ක⮎ຠ࡞ࡈࡔ࠺ ࠖࠤ࡚ࠪࡦᝄ⥝⽷࿅㩷 ᐔᚑ㪈㪏ᐕᐲഥᚑࠍฃߌߡ ߦ 㑐 ߔ ࠆ ᕆ ᕈ ਛ Ქ ∝ ߩ ታ ᘒ ⺞ ᩏ 㪅㩷 㪫㪿㪼㩷 ታᣉߒߚ㧚㩷 㪡㪸㫇㪸㫅㪼㫊㪼㩷 㪡㫆㫌㫉㫅㪸㫃㩷 㫆㪽㩷 㪫㫆㫏㫀㪺㫆㫃㫆㪾㫐㪃㩷 㪈㪏㪃㩷 㪉㪏㪌㪄㪐㪊㩷 㩿㪉㪇㪇㪌㪀㩷 ᒁ↪ᢥ₂ 㪈㪊㪀㩷 㪛㫉㫌㪾㪛㪼㫏㩷 㪜㪻㫀㫋㫆㫉㫀㪸㫃㩷 㪪㫋㪸㪽㪽㪅㩷 㪛㫀㫇㪿㪼㫅㪿㫐㪻㫉㪸㫄㫀㫅㪼㪅㩷 㪈㪀㩷 㪛㪸㫎㫊㫆㫅㩷 㪛㪃㩷 㪩㪼㫀㪻㩷 㪢㪅㩷 㪝㪸㫋㫀㪾㫌㪼㪃㩷 㪸㫃㪺㫆㪿㫆㫃㩷 㪸㫅㪻㩷 㪛㫉㫌㪾㪛㪼㫏㩷 㪛㫉㫌㪾㩷 㪜㫍㪸㫃㫌㪸㫋㫀㫆㫅㪅㪤㫀㪺㫉㫆㫄㪼㪻㪼㫏㩷 㪟㪼㪸㫃㫋㪿㪺㪸㫉㪼㩷 㫇㪼㫉㪽㫆㫉㫄㪸㫅㪺㪼㩷 㫀㫄㫇㪸㫀㫉㫄㪼㫅㫋㪅㩷 㪥㪸㫋㫌㫉㪼㪃㩷 㪊㪏㪏㪃㩷 㪉㪊㪌㪄㪏㩷 㪪㪼㫉㫀㪼㫊㪅㩷㪿㫋㫋㫇㪑㪆㪆㫎㫎㫎㪅㫋㪿㫆㫄㫊㫆㫅㪿㪺㪅㪺㫆㫄㪆㪿㫆㫄㪼㪆㪻㫀㫊㫇㪸㫋㪺㪿㪃㩷 㩿㪈㪐㪐㪎㪀㩷 㪸㪺㪺㪼㫊㫊㪼㪻㩷㫆㫅㩷㪉㪎㩷㪪㪼㫇㪅㩷㪉㪇㪇㪎㪅㩷 㩷 㪉㪀㩷 㪪㪿㫆㫁㫀㩷㪪㪃㩷㪤㫌㫂㪸㫀㪫㪃㩷㪬㪺㪿㫀㫄㫌㫉㪸㩷㪥㪅㩷 ฦ⥃ᐥ⑼ߢߺࠄ 㪈㪋㪀㩷 㪪㪿㫀㫉㪸㪾㪸㫄㫀㩷㪤㪅㩷 ᐔᚑ㪈㪍ᐕᐲෘ↢ഭ⑼ቇ⎇ⓥ⾌ ࠇࠆ⌧⌁㓚ኂ㧧♧ዩ∛ߦ߅ߌࠆ⌧⌁㓚ኂ㧘 ഥ㊄ෘ↢ഭ⑼ቇ․⎇ⓥᬺ㪅ޟක⮎ຠ⽼ 㪧㫉㫆㪾㫉㪼㫊㫊㩷㫀㫅㩷㪤㪼㪻㫀㪺㫀㫅㪼㪃㩷㪉㪋㪃㩷㪐㪏㪎㪄㪐㪉㩷㩿㪉㪇㪇㪋㪀㩷 ᄁߦ㑐ߔࠆ࿖᳃ᗧ⼂╬⺞ᩏߦ㑐ߔࠆ⎇ⓥ✚ 㪊㪀㩷 㪞㫆㫋㫋㫃㫀㪼㩷㪛㪡㪃㪼㫋㩷㪸㫃㧦㪘㫊㫊㫆㪺㫀㪸㫋㫀㫆㫅㩷㫆㪽㩷㫊㫃㪼㪼㫇㩷㫋㫀㫄㪼㩷㫎㫀㫋㪿㩷 ― 179 ― ႎ๔ᦠޠ㪃㩷㪉㪇㪇㪌㩷 昭和大学薬学雑誌 第１巻 第 2 号 2010 年 㪈㪌㪀㩷 ᄢⴐ⮎Ꮏᬺදળ㪅㩷 ╙㪉㪎࿁ᶖ⾌⠪ᗧ⼂⺞ᩏ㧘 㪈㪐㪀㩷 㪩㫀㪺㫂㪼㫃㫊㩷 㪢㪃㩷 㪤㫆㫉㫉㫀㫊㩷 㪩㩷 㪡㪃㩷 㪥㪼㫎㫄㪸㫅㩷 㪟㩷 㪼㫋㩷 㪸㫃㪅㩷 㪿㫋㫋㫇㪑㪆㪆㫎㫎㫎㪅㫁㫊㫄㫀㪅㫁㫇㪆㫉㪼㫊㪼㫉㪺㪿㪆㫀㫊㫀㫂㫀㪶㪉㪎㪆㪉㪎㪅㫇㪻㪽㪃㩷 㪛㫀㫇㪿㪼㫅㪿㫐㪻㫉㪸㫄㫀㫅㪼㩷 㫀㫅㩷 㫀㫅㫊㫆㫄㫅㫀㪸㪺㩷 㪽㪸㫄㫀㫃㫐㩷 㫇㫉㪸㪺㫋㫀㪺㪼㩷 㪸㪺㪺㪼㫊㫊㪼㪻㩷㫆㫅㩷㪈㩷㪪㪼㫇㪅㩷㪉㪇㪇㪊㩷 㫇㪸㫋㫀㪼㫅㫋㫊㪑㩷 㪸㩷 㪻㫆㫌㪹㫃㪼㪄㪹㫃㫀㫅㪻㩷 㫊㫋㫌㪻㫐㪅㩷 㪫㪿㪼㩷 㪡㫆㫌㫉㫅㪸㫃㩷 㫆㪽㩷 㪈㪍㪀㩷 㪠㫑㫌㫄㫀㫊㪸㫎㪸㩷 㪤㪃㩷 㪤㪸㫋㫊㫌㪹㪸㫉㪸㩷 㪤㪃㩷 㪠㫂㪼㪻㪸㩷 㪪㪃㩷 㪼㫋㩷 㪸㫃㪅㩷 㪚㫃㫀㫅㫀㪺㪸㫃㩷㪧㪿㪸㫉㫄㪸㪺㫆㫃㫆㪾㫐㪃㩷㪉㪊㪃㩷㪊㪋㪄㪉㪋㪉㩷㩿㪈㪐㪏㪊㪀㩷 㪜㫍㪸㫃㫌㪸㫋㫀㫆㫅㩷㫆㫅㩷㫋㪿㪼㩷㫉㫆㫃㪼㩷㫆㪽㩷㪺㫆㫄㫄㫌㫅㫀㫋㫐㩷㫇㪿㪸㫉㫄㪸㪺㫀㫊㫋㩷 㪉㪇㪀㩷 㪩㫀㪺㪿㪸㫉㪻㫊㫆㫅㩷㪞㩷㪪㪃㩷㪩㫆㪼㪿㫉㫊㩷㪫㩷㪘㪃㩷㪩㫆㫊㪼㫅㫋㪿㪸㫃㩷㪣㪃㩷㪼㫋㩷㪸㫃㪅㩷 㪽㫆㫉㩷㫅㫆㫅㪄㫇㫉㪼㫊㪺㫉㫀㫇㫋㫀㫆㫅㩷㪻㫉㫌㪾㩷㪺㫆㫅㫊㫌㫄㪼㫉㩷㫊㪸㫋㫀㫊㪽㪸㪺㫋㫀㫆㫅㪅㩷 㪫㫆㫃㪼㫉㪸㫅㪺㪼㩷 㫋㫆㩷 㪻㪸㫐㫋㫀㫄㪼㩷 㫊㪼㪻㪸㫋㫀㫍㪼㩷 㪼㪽㪽㪼㪺㫋㫊㩷 㫆㪽㩷 㪟㪈㩷 㪡㪸㫇㪸㫅㪼㫊㪼㩷㪡㫆㫌㫉㫅㪸㫃㩷㫆㪽㩷㪛㫉㫌㪾㩷㪠㫅㪽㫆㫉㫄㪸㫋㫀㫆㫅㪃㩷㪋㪃㩷㪉㪎㪄㪊㪉㩷 㪸㫅㫋㫀㪿㫀㫊㫋㪸㫄㫀㫅㪼㫊㪅㩷 㪡㩷 㪚㫃㫀㫅㩷 㪧㫊㫐㪺㪿㫆㫇㪿㪸㫉㫄㪸㪺㫆㫃㪃㩷 㪉㪉㪃㩷 㩿㪉㪇㪇㪉㪀㩷 㪌㪈㪈㪄㪌㩷㩿㪉㪇㪇㪉㪀㩷 㪈㪎㪀㩷 㪰㪸㪼㩷 㪫㩷 㪃㩷 㪰㪸㪼㩷 㪜㪅㩷 㪨㫌㫎㫊㫋㫀㫆㫅㫅㪸㫀㫉㪼㩷 㪪㫌㪼㫍㪼㫐㩷 㫆㪽㩷 㪉㪈㪀㩷 㪬㪺㪿㫀㫄㫌㫉㪸㩷㪥㪃㩷㪟㪸㫊㪿㫀㫑㫌㫄㪼㩷㪰㪃㩷㪛㫆㫀㫂㪸㫎㪸㩷㪤㪃㩷㪼㫋㩷㪸㫃㪅㩷 ↢ 㪚㫆㫅㫊㫌㫄㪼㫉㩷 㪘㫎㪸㫉㪼㫅㪼㫊㫊㩷 㫆㪽㩷 㪪㪼㫉㫀㫆㫌㫊㩷 㪪㫀㪻㪼㩷 㪜㪽㪽㪼㪺㫋㫊㩷 ᵴ⠌ᘠ∛ߣ⌧⌁ߩᷓ㑐ଥࠍ⠨߃ࠆ㪄ߊ 㪘㫊㫊㫆㪺㫀㪸㫋㪼㪻㩷 㫎㫀㫋㪿㩷 㪥㫆㫅㪄㪧㫉㪼㫊㪺㫉㫀㫇㫋㫀㫆㫅㩷 㪛㫉㫌㪾㫊㪅㩷 㪡㫇㫅㩷 㫁㩷 ઍ ߩ ⺞ ᩏ ߆ ࠄ 㪅㩷 ⸻ ᢿ ߣ ᴦ ≮ 㪃㩷 㪐㪋㪃㩷 㪌㪇㪈㪄㪌㪈㪈㩷 㪧㪿㪸㫉㫄㩷㪟㪼㪸㫃㫋㪿㩷㪚㪸㫉㪼㩷㪪㪺㫀㪃㩷㪊㪇㪃㩷㪌㪌㪊㪄㪎㩷㩿㪉㪇㪇㪋㪀㩷 㩿㪉㪇㪇㪍㪀㩷 㪈㪏㪀㩷㪪㪸㫊㪸㫂㫀㩷㪢㪃㩷㪦㪿㪹㪸㫐㪸㫊㪿㫀㩷㪤㪃㩷㪢㫆㪿㫐㪸㫄㪸㩷㪥㪃㩷㪼㫋㩷㪸㫃㪅㩷 ߆ߗ 㪉㪉㪀㩷 㪟㫆㫅㪻㪸㩷 㪥㪃㩷 ␠ળ⺞ᩏ߳ߩࠗࡦ࠲ࡀ࠶࠻⺞ᩏ ⮎⾼ᤨߦ߅ߌࠆᔊᘕ㊀ᛩਈߩ⏕⁁ᴫ ߩዉࠍߋࠆ⺰ὐ㩷 㧙Ყセታ㛎⺞ᩏߩ⚿ᨐ ߅ ࠃ ߮ ឃ ዩ 㓚 ኂ ᖡ ൻ ߩ ⁁ ᴫ ⺞ ᩏ㩷 ߆ࠄ㧙㩷 㩷 ഭ⛔⸘⺞ᩏႎ㪃㩷㪌㪎㪃㩷㪈㪉㪄㪉㪇㩷㩿㪉㪇㪇㪌㪀㩷 㪰㪸㫂㫌㪾㪸㫂㫌㩷㪱㪸㫊㫊㪿㫀㪃㩷㪈㪉㪏㪃㩷㪈㪊㪇㪈㪄㪐㩷㩿㪉㪇㪇㪏㪀㩷 ― 180 ― 昭和大学薬学雑誌 第１巻 第 2 号 2010 年 Current Conditions Regarding Consumers and Nonprescription Sleep Aid drugs and the Pharmacist's Role in their Sales Keiko Sasaki, Ken-ichi Saguchi, Nana Matumoto, Mari Kogo, Isao Saito, Jyunichi Mashimo, Hiroaki Ohi, Nanko Miura, Miwako Kamei and Takashi Tobe 㪪㪺㪿㫆㫆㫃㩷㫆㪽㩷㪧㪿㪸㫉㫄㪸㪺㫐㪃㩷㪪㪿㫆㫎㪸㩷㪬㫅㫀㫍㪼㫉㫊㫀㫋㫐㩷 㩷 Abstract Objectives: To investigate the coping with the insomnia of general public, the actual situation of a person with experience of taking sleep aid drugs, the expectation to a pharmacist when purchasing sleep aid drugs, and to examine the coping of a pharmacist when selling sleep aid drugs. Methods: The survey items examined the measures taken for insomnia and use of sleep aids by 400 males and females, selected from research company monitors. Individuals ranged in age from 20 to 69 years and were residents of Tokyo, Kanagawa, Chiba and Saitama prefectures. Results: Among all respondents, 65.3% would see a physician when faced with difficulty sleeping if advised. Besides, among subjects who experienced difficulty sleeping more than 3 times a week, 24.1% consulted with a physician. The major reason for not purchasing nonprescription sleep aid drugs when having difficulty falling asleep was "afraid of it being habit-forming (51.7%)." As an expectation of a pharmacist when purchasing sleep aid drugs, the responses that ranked highly were "instruct me about the drug's side effects (65.0%) ", " instruct me about the items of caution for after taking the drug (53.0%) ", and "expecting the drug that is appropriate for me to be selected (49.0%)." Regarding selling environment, 55% of respondents answered "purchasing the drug upon consulting with a pharmacist." Conclusions: A pharmacist is demanded to check the frequency and duration of sleep difficulty and to encourage clinic visits to consult with a physician if needed, and to eliminate excessive anxiety came from the images of medical sleeping drugs. Furthermore, selection of drags to serve symptoms and to present the information about the drug's side effects and the point to notice after taking drags are demanded to a pharmacist. Key Words㧦sleep disorder, nonprescription drug, sleep aid drug, web survey 㪩㪼㪺㪼㫀㫍㪼㪻㩷㪏㩷㪤㪸㫐㩷㪉㪇㪈㪇㪒㩷㪸㪺㪺㪼㫇㫋㪼㪻㩷㪍㩷㪡㫌㫃㫐㩷㪉㪇㪈㪇㪅㩷 㩷 㩷 ― 181 ―
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