Original Articles / ·¡ro ´
Áª«µ¦r¢g ¢¼µ¦ 2550; 17(2): 37 - 42
J Thai Rehabil Med 2007; 17(2): 37 - 42
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ABSTRACT
Measurement of Residual Urine by
Portable Ultrasound Scanner Compared with Catheterization Method in
Spinal Cord Lesion Patients with
Neurogenic Bladder
Kothsompong H, Tamnanthong N.
Department of Rehabilitation Medicine, Faculty of Medicine, Khon Kaen
University
Objectives: To determine the accuracy of residual urine (RU) measured
by the portable ultrasound scanner
compared with catheterization
method.
Study design: Experimental, comparative study
Setting: The rehabilitation ward,
Srinagarind Hospital
Subjects: Thirty-three spinal cord
lesion patients with neurogenic
bladder managed by intermittent
catheterization.
Methods: Initially, post-voiding
residual urine was assessed by the
first ultrasound scanner measurement
(US1) compared to catheterization
method (Cath1) with double-blind
technique. Fifty ml. of normal saline
(NSS) was introduced via foley
Correspondence to: Dr. Hathaimas
Kothsompong; Department of
Rehabilitation Medicine Maharat
Nakornratchasrima Hospital,
Changpheuk Road, Amphur Mueng,
Nakornratchasrima 30000
E-mail: [email protected]
catheter, then assessed by the
second scanner measurement (US2 ).
Thereafter, additional 50 ml. of NSS
was introduced for the third scanner
measurement (US 3). Finally, the
bladder volume was assessed by
catheterization method (Cath2) and
was compared to the constant value
of 100 ml. Accuracy and clinical
agreement of RU measured by the
ultrasound scanner and the catheterization were evaluated.
Results: Thirty-three patients were
included; 18 of all had traumatic spinal
cord injury; 21 were males and 10
were females. Average age was 40.25
years old (range 20 to 65 years old).
The Bland and Altman plot was
showed clinical agreement of US1vs
Cath1 (limit ± 50 ml. = 64.74%, 95%
CI = 51.25 - 84.23%) and US3vs Cath2
(limit ± 50 ml. = 64.52%, 95% CI =
47.67 - 81.36%). When compared US1
with Cath1and US3 with Cath2 , the sensitivities of the ultrasound scanner
were 0.8888889 and 0.5172414,
respectively. There was low agreement of US2 vs 50 ml, US3 vs100 ml,
and Cath2 vs 100 ml.
Conclusion: The portable ultrasound
scanner is useful for evaluation of RU
when compared with the catheterization method. It is more accurate
when the RU is more than 100 ml.
Key words: residual urine, neurogenic
bladder, spinal cord lesion, portable
ultrasound, intermittent catheterization
J Thai Rehabil Med 2007; 17(2): 37 - 42
- 37 -
´¥n°
ª´»¦³r: Á¡º°É ¦³Á¤·ªµ¤Â¤n¥¶
°µ¦ª´¦·¤µ{µª³oµ (Residual urine, RU) oª¥µ¦ÄoÁ¦º°É °´¨¦µ
µªrÁ¦¸¥Á¸¥´µ¦ª{µª³
¦¼Âµ¦ª·¥´ : Äoª· ¸ ¨° «¹¬µ
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Ã¥o¼ ¶µ¦ª·¥´ ÄoÁ¦º°É °´¨¦µµªr¥®¸É °o
Bladder scan (US1) Á¦¸¥Á¸¥´ª·¸
ª{µª³ (Cath1) ¹É ¤¸¡¥µµ¨o¼ ªn ¥
ª·¥´ Á}ª Ã¥dnµ
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{µª³ 50 ¤¨. ª´oª¥Á¦º°É °´¨¦µµªr
(US2 ) ¨oªÄnʶÁ¨º°Á
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¨³ª´Ê¶ oª¥Á¦º°É °´¨¦µµªr (US3)
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Áª«µ¦r¢g ¢¼µ¦ 2550; 17(2)
(18 ) µ Bland and Altman plot
¡ªnµ¤¸ªµ¤°¨o°´¦³®ªnµ US1
´ Cath1 (¸É limit ± 50 ml. = 64.74%,
95% CI = 51.25 - 84.23%) ¨³ US3
´ Cath2 (¸É limit ± 50 ml. = 64.52%,
95% CI = 47.67 - 81.36%) Ã¥ªµ¤Åª
°Á¦º°É °´¨¦µµªrĵ¦ª´¦·¤µ
{µª³oµ Á¤ºÉ°Á¸¥¦³®ªnµ US1 ´
Cath 1 ¨³ US 3 ´ Cath 2 Án µ ´
0.8888889 ¨³ 0.5172414 µ¤¨¶´
¨³¤¸ªµ¤°¨o°´o°¥ ¦³®ªnµ
US2 ´ 50 ¤¨., US3 ´100 ¤¨. ¨³
Cath2 ´ 100 ¤¨.
¦»: µ¤µ¦¶Á¦º°É °´¨¦µµªrÂ
¡¡µ¤µÄo¦³Á¤·¦·¤µ{µª³oµ
µ¦ª{µª³Åo Ã¥³¤¸
ªµ¤Â¤n¥¶Á¤º°É ¶¤µª´¦·¤µ{µª³
oµ¤µªnµ 100 ¤¨.
¶¶´: residual urine, neurogenic
bladder, spinal cord lesion, portable
ultrasound, intermittent catheterization
Áª«µ¦r¢g ¢¼µ¦ 2550; 17(2): 37 - 42
¶
¦· ¤ µ{ µª³o µ ®¨´ µµ¦
´nµ¥{µª³ (post - voiding residual
urine, RU) ¤¸ªµ¤¶´Äµ¦¡·µ¦µ
¨³´·Äĵ¦´µ¦´o¼ ªi ¥£µª³
¦³Á¡µ³{µª³¡·µ¦ (neurogenic
bladder)(1) Án o¼ ªi ¥¸¤É ¦¸ °¥Ã¦Å
´®¨´
(spinal cord lesion) ¨³¤¸£µª³¦³Á¡µ³
{µª³¡·µ¦°µ³ f
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µ¦ª{µª³Á}¦³¥³ (intermittent
catheterization, IC) ¹É ¶ª¦´Ê
°µ¦
ª{µª³
¹Ê ´¦·¤µ RU ¸ªÉ ´ Åo
Ä{»´ µ¦ª{µª³Á}ª·¸
¤µ¦µÄµ¦ª´¦·¤µ{µª³oµ
(RU)(2) ÂnÈÁ}ª·¸¸É°µÁ¸É¥n°£µª³
·ÁºÊ°Â¨³µ¦µÁÈn°n°{µª³
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¼ª{µª³Ã¥Å¤n¶Á}(3) °¸´Ê ¥´
Á¸É¥n°£µª³´¨nµª °µ¸Ê ¥´¤¸
J Thai Rehabil Med 2007; 17(2)
¦µ¥µ¸¡É ªnµµ¦ª{µª³ Á¡º°É ª´
¦·¤µ{µª³oµ ¤¸ªµ¤¨µÁ¨ºÉ°
Åo¹ 27%(4) ¶Ä®o¨¨·¡¨µÅo
µ¦ª´ ¦· ¤ µ RU Ã¥Äo Á ¦ºÉ °
°´¨¦µµªr¡¡µ (portable ultrasound scanner) ´Á}ª·¸¸É¤µ¦µ
Äoµn ¥ ³ª ¨³Å¤n°o Á¦¸¥¤°»¦r
¥n» ¥µ ¤¸¦µ¥µªnµÁº°É º°Åo(1,2,3,5) ¦ª¤´Ê
o¼ ¸É µ¤µ¦ÄoÅoÅÈ ¤n¶Á}o°¤¸¦³µ¦r¨³ªµ¤¶µ¤µ¤µ¥(6) µ¤µ¦
ª´¦·¤µ RU Åo´ÊÂn 50-700 ml.(5)
¹É¤¸nµªµ¤Â¤n¥¶Ã¥¦ª¤ (overall
accuracy) 94%, ªµ¤Åª (sensitivity)
97% ¨³ªµ¤¶Á¡µ³ (specificity)
91%(5) ÂnÁ}¦µ¥µ¸ÉÄoÁ¦ºÉ°°´¨¦µ
µªr¸ÉÂnµ´ ¨³¤¸¤µ¦µÄ
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- 38 -
Ân µµ¦¶Á¦ºÉ ° °´ ¨ ¦µµªr
¥¸®É °o Bladder Scan ¦n» BVI 3000 ¤µÄo
ĵ¦ª´¦·¤µ RU
°o¼iª¥¸É®°
o¼ i ª ¥Áª«µ¦r ¢g ¢¼ æ¡¥µµ¨
«¦¸¦·¦r ¡ªnµµ¤µ¦ª´nµ¦·¤µ
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ĵ¦®µ¦·¤µ RU Ã¥ª·¸µ¦ª
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- o¼ ªi ¥¦³Á¡µ³{µª³¡·µ¦µ
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- µµ¦¶ª
µ´ª°¥nµoª¥
°¤¡·ªÁ°¦rÃ¥Äo榤 Stats
Direct Ã¥¶®nµÁ¡º°É ¶ª n
 correlation ´¸Ê
Correlation coefficient under
null hypothesis (H0) = 0.97
Correlation coefficient under
alternative hypothesis (H1) =
0.90
∝ = 0.05
power = 0.8
¹É ¶ªÅo n = 25 ÂnÄ®o n
Á} 30 Á¡º°É Ä®oÁ}´ªÂ
°
µ´ª°¥nµ¸ÁÉ } normal distribution
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ªÁª¦³Á¸¥Á¡º°É ®µ
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°¦³µÁ·{µª³¸É µn ¤µ ÅoÂn
¨ intravenous pyelography (IVP),
voiding cystourethrography (VCUG),
ultrasound KUB system, urine analysis
(UA), urine culture
®¨´
´nµ¥{µª³Â¨oª ª´¦·¤µ
post - voiding residual urine (RU) å
o¼¶µ¦ª·´¥ÄoÁ¦ºÉ°°´¨¦µµªr¥¸É®o°
Bladder Scan(US1) Á¦¸¥Á¸¥´ª·¸
ª{µª³ (Cath1) ¹É ¤¸¡¥µµ¨o¼ ªn ¥
ª·¥´ ¶µ¦ªoª¥µ¥ª{µª³·
foley catheter 2 ®µ
µ 14F Ã¥
d´nµ
o°¤¼¨¸Éª´ÅoŤnÄ®oo¼¶µ¦ª´
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¦³°¸¥µ¡¨µ·
µ 50 ¤¨.
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¨³®´¡´¨µ¥µ¥Á¡ºÉ°Å¤nÄ®oʶÁ¨º°
¸ÄÉ nÁ
oµÅÅ®¨°°¤µ ª´ RU oª¥Á¦º°É
°´¨¦µµªr (US2) µ´Ê ÄnʶÁ¨º°Á¡·¤É
Á
oµÅ°¸ 50 ¤¨. ¨oªª´Ê¶oª¥°´¨¦µ
µªr°¸ ¦´Ê (US3) ¹ª{µª³ (Cath2)
Á}¦´Ê »oµ¥
¥¹º°Á·µ¦ª{µª³
°
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Á· ¦µ«µÁºÊ ° ¦n ª ¤´ µ¦
®o µ o ° ¨o ª ®¤» µ¥ªÃ¥¦°
¡¦o°¤Á¨ºÉ°
¥´µ¥°°¤µÁº°»
n°¸É ³¹µ¥ª°°¤µ
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³¶Ã¥o¼ ¶µ¦ª·¥´ Á¡¸¥Á¸¥ª¹É f
ÄoÁ¦º°É °¥nµ¶µ Ã¥nµ¸É ´¹
³Á}nµ¸ªÉ ´ Ã¥Á·¸ÂÉ ¤n¥¶¸É » ¨³
ª´Åoµn ÁnµÁ·¤·n°´ 3 ¦´Ê
Outcome measurement
US1 = nµ¦·¤µ RU ¸ªÉ ´ ¦´Ê ¦
oª¥Á¦º°É °´¨¦µµªr
Cath1 = nµ¦·¤µ RU ¸ªÉ ´ Åoµ
µ¦ª{µª³®¨´ª´ US1
US2 = ¦·¤µ{µª³oµ¸ªÉ ´ Åo
µÁ¦º°É °´¨¦µµªrÁ¤º°É Änʶ
Á¨º°Á
oµÅ 50 ¤¨.
US3 = ¦·¤µ{µª³oµ¸ªÉ ´ Åo
µÁ¦º°É °´¨¦µµªrÁ¤º°É Änʶ
Á¨º°Á
oµÅ°¸ 50 ¤¨.
Cath2 = ¦·¤µ{µª³¸É ªÅo
¦´Ê »oµ¥®¨´µª´ US3
Statistical analysis
·Á· ·¡¦¦µ ¶®¦´
o°¤¼¨´ªÉ Å
°oÁ¼
oµ¦´µ¦«¹¬µ
·Á· ·ª·Á¦µ³®r
- Á¦¸¥Á¸¥ RU ¸ªÉ ´ Åoµµ¦
Äo°¨´ ¦µµªr ¨³µ¦ª
{µª³ Ã¥Äoª· ¸ µ¦¦³Á¤·
clinical agreement ¦³®ªnµ
°ª·¸ µ¤ª·
¸ ° Bland and
Altman(11)
- ®µnµªµ¤Åª (sensitivity) ¨³
ªµ¤¶Á¡µ³ (specificity)
°
Á¦º°É °´¨¦µµªrÃ¥Á¦¸¥
Á¸¥nµ RU ¸ÁÉ ¦º°É ª´Åo´ nµ
¸ÅÉ oµª·¸ ª{µª³Ã¥
Á¦¸¥Á¸¥¸É ¶ª RU ¸É
¤µªnµ®¦º°Ánµ´ 100 ¤¨.
¨³o°¥ªnµ 100 ¤¨.
µ¦«¹¬µ¸ÊÅo¦´´»»ª·´¥
µ iµ¥ª·´¥³Â¡¥«µ¦r ¤®µª·¥µ¨´¥
°Ân
¨µ¦«¹¬µ
o°¤¼¨´ªÉ Å
o¼ ªi ¥¶ª 31 °µ¥»´Ê Ân 2065 e (Á¨¸¥É 40.25 e) Á}µ¥ 21 ,
®· 10 µ¦ª·· ´¥Ã¦Â¨³¦³´
°
¦°¥Ã¦Å
´®¨´´Âĵ¦µ¸É 1
Á}¦°¥Ã¦¸ÉÅ
´®¨´·¤¼¦r 19
¨³·Å¤n¤¼¦r 12
¨µ¦«¹ ¬µÁ¦¸ ¥ Á¸ ¥ ¦³®ªn µ
µ¦ª´ RU oª¥µ¦Äo°¨´ ¦µµªr (US)
´µ¦ª{µª³ (Cath)
¨µ¦ª´ RU oª¥ª·¸ US ´ Cath
´¸Ê
US1 ¤¸µn ´Ê Ân 0-632 ¤¨. (Á¨¸¥É
214.87 ± 154.59 ¤¨.)
Cath1 ¤¸µn ´Ê Ân 15-480 ¤¨. (Á¨¸¥É
190.07 ± 116.01 ¤¨.)
US2 ¤¸µn ´Ê Ân 0-138 ¤¨. (Á¨¸¥É
45.419 ± 38.62 ¤¨.)
US3 ¤¸µn ´Ê Ân 8-207 ¤¨. (Á¨¸¥É
99.19 ± 46.74 ¤¨.)
Cath2 ¤¸µn ´Ê Ân 92-202 ¤¨. (Á¨¸¥É
129.10 ± 26.31 ¤¨.)
Á¤ºÉ°®µªµ¤°¨o° Bland and
Altman agreement plot ¡ªnµ¤¸ clinical agreement ¦³®ªnµnµ US1 ´ Cath1
¨³ US3 ´ Cath2 ÂnŤn¤¸ agreement
¦³®ªnµ US2 ´ 50 ¤¨., US3 ´100 ¤¨.,
¨³ Cath2 ´ 100 ¤¨. ´¦¼¸É 2, 3, 4,
5, 6
µ¦ª·· ´¥Ã¦
Spinal cord injury
18
C- spondylotic myelopathy 4
Transverse myelitis
4
Spinal cord tumor
4
TB- spondylitis with cord compression 1
¦³´
°¦°¥Ã¦Å
´®¨´
´Ê Ân C8
¹Ê Å
T1 - T6
T7 -T12
´Ê Ân L1 ¨¤µ
9
7
11
4
µ¦µ¸É 1 µ¦ª·· ´¥Ã¦Â¨³¦³´¦°¥Ã¦Å
´®¨´
°o¼ ªi ¥¸ÁÉ
oµ¦´µ¦«¹¬µ 31
- 39 -
Áª«µ¦r¢g ¢¼µ¦ 2550; 17(2)
Difference (US2-50) (ml.)
Difference (US3- 100) (ml.)
Average vol. (ml.)
Average vol. (ml.)
¦¼¸É 2  Bland and Altman agreement plot ¦³®ªnµ US1´
Cath1Á¤º°É ¶´Ä®o¤¸ µn ªµ¤nµ
° US1´ Cath1µnµÁ¨¸¥É ŤnÁ· ±
50 ¤¨. ¡ªnµ¤¸ 21 µ 31 n¼ (67.74%) ¸¤É ¸ ªµ¤nµ´Å¤nÁ· ± 50 ¤¨.
(95%CI = 51.25-84.23%)
¦¸É 5  Bland and Altman agreement plot ¦³®ªnµ US3´ 100
¤¨. Á¤º°É ¶´Ä®o¤¸ µn ªµ¤nµ
° US3 ´ 100 ¤¨. µnµÁ¨¸¥É ŤnÁ·
± 20 ¤¨. (·Á} 20%
° 100 ¤¨.) ¡ªnµ¤¸Á¡¸¥ 16 µ 31 n¼
(51.61%) ¸¤É ¸ ªµ¤nµ´Å¤nÁ· ± 20 ¤¨. (95%CI = 46.16-57.07%)
Difference (US3-Cath2) (ml.)
Difference (ml.)
Average vol. (ml.)
¦¼¸É 3  Bland and Altman agreement plot ¦³®ªnµ US3 ´
Cath2Á¤º°É ¶´Ä®o¤¸ µn ªµ¤nµ
° US3 ´ Cath2µnµÁ¨¸¥É ŤnÁ· ± 50
¤¨. ¡ªnµ¤¸ 20 µ 31 n¼ (64.52%) ¸¤É ¸ ªµ¤nµ´Å¤nÁ· ± 50 ¤¨. (95%CI
= 47.67-81.36%)
Difference (US2-50) (ml.)
Average vol. (ml.)
¦¼¸É 4  Bland and Altman agreement plot ¦³®ªnµ US2 ´ 50
¤¨.Á¤º°É ¶´Ä®o¤¸ µn ªµ¤nµ
° US2 ´ 50 ¤¨.µnµÁ¨¸¥É ŤnÁ· ± 10
¤¨. (·Á} 20%
° 50 ¤¨.) ¡ªnµ¤¸Á¡¸¥ 11 µ 31 n¼ (35.48%)
¸¤É ¸ ªµ¤nµ´Å¤nÁ· ± 10 ¤¨. (95%CI = 30.26-40.71%)
J Thai Rehabil Med 2007; 17(2)
- 40 -
Average vol. (ml.)
¦¼¸É 6  Bland and Altman agreement plot ¦³®ªnµ Cath2´
100 ¤¨.Á¤ºÉ ° ¶´ Ä®o ¤¸ n µ ªµ¤n µ
° Cath 2´ 100 ¤¨.µ
meanŤnÁ· ± 20 ¤¨. (·Á} 20%
° 100 ¤¨.) ¡ªnµ¤¸Á¡¸¥ 13Ä
31 n¼ (41.94%) ¸É¤¸ªµ¤nµ´Å¤nÁ· ± 20 ¤¨.(95%CI = 36.5547.32%)
Á¤ºÉ°¶nµ¦·¤µ{µª³oµ¸Éª´
Åoµ´Ê °ª·Á¸ ¡º°É ®µªµ¤ÅªÂ¨³ªµ¤
¶Á¡µ³
°Á¦º°É °´¨¦µµªrĵ¦ª´
nµ RU ¸É¤µªnµ®¦º°Ánµ´ 100 ¤¨.
¹É Á}nµ¤µ¦µÂ¨³º°ªnµ¤¸ªµ¤¶´
ĵ·´·Á¡¦µ³¤¸¨n°µ¦´·Ä
ª{µª³ ´µ¦µ¸É 2
Crosstabulation
Sensitivity
(95% CI)
Specificity
(95% CI)
PPV
(95% CI)
NPV
(95% CI)
US1 vs Cath1
US3 vs Cath2
(Á¤º°É ¦³Á¡µ³{µª³¤¸ªµ¤»¦·) (Á¤º°É ¦³Á¡µ³{µª³¤¸ªµ¤» 100 ¤¨.)
0.8888889
0.5172414
(0.7084131-0.9764725)
(0.325315-0.7055144)
1
0.5
(0.3976354-1)
(0.125791-0.874209)
1
0.9375
(0.8575264-1)
(0.6976793-0.9984189)
0.5714286
0.0666667
(0.1840516-0.9010117)
(0.0016864-0.3194846)
µ¦µ¸É 2  ªµ¤Åª (sensitivity) ¨³ ªµ¤¶Á¡µ³ (specificity)
°Á¦º°É °´¨¦µµªr
Ã¥Á¦¸¥Á¸¥nµ RU ¸ÉÁ¦ºÉ°ª´Åo ´¸ÉÅoµª·¸ª{µª³Ã¥Á¦¸¥Á¸¥¸É¶ª RU
¸¤É µªnµ®¦º°Ánµ´ 100 ¤¨. ¨³¸É °o ¥ªnµ 100 ¤¨. (PPV = Positive Predictive Value, NPV =
Negative Predictive Value)
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