Hoshi University
氏
名
松本
貴之
所
属
医薬品化学研究所
職
位
講師
機能形態学研究室
学
位
最終学歴
教育活動
（担当授業科目）
博士(薬学)
星薬科大学大学院薬学研究科博士後期課程中退
細胞の構造と機能、バイオスタティスティクス、
薬学英語 IIB、生物系実習 II
研究活動
（研究テーマ）
所属学会
生活習慣病病態時における血管機能障害の解析
日本薬理学会、日本循環薬理学会、日本平滑筋学会、日本薬学会、日本
糖尿病・肥満動物学会、日本糖尿病 学会、日本心脈管作動物質学会、The
American Heart Association (AHA)、The American Physiological
Society (APS)、The American Society for Pharmacology and
Experimental Therapeutics (ASPET)、日本くすりと糖尿病学会
学内活動
（役職・委員等）
学外活動
（委員会委員等）
日本薬理学会学術評議員、Fellow of the American Heart Association
(FAHA) (Council for High Blood Pressure Research)、The Review of
Diabetes Studies: Board of Reviewers、Conference Papers in
Medicine: Editorial Board
研究業績等
（受賞歴）
2006 年 平成 18 年度星薬科大学大谷記念研究助成金、2006 年 鈴木謙三記念財団法人医科学応用研究財団 第 26
回(平成 18 年度 )研究助成金 、2007 年 日本平滑筋学会 第三回栗山熙賞、 2009 年 平成 21 年度日本薬学会関 東支
部奨励賞、 2009 年財団法人武田科学振興財団 2009 年度「薬学系研究奨励 (薬学)」、2009 年 第 26 回 (2009 年度)
内藤記念海外研究留学助成金、2010 年 The Harry Goldblatt New Investigator Award Finalist: The American Heart
Association, High Blood Pressure Council.、2012 年 The 2012 International Early Career Physiologist Travel Award: The
American Physiological Society、2012 年 公益財団法人 三島海雲記念財団第 50 回 研究奨励金
（主な著書・論文）
1. TAGUCHI, K., MATSUMOTO, T., KAMATA, K. AND KOBAYASHI, T.: Suppressed
G-protein-coupled receptor kinase 2 activity protects female dia betic-mouse aorta against endothelial
dysfunction. Acta. Physiol , 207, 142-155 (2013)
2. ISHIDA, K., MATSUMOTO, T., TAGUCHI, K., KAMATA, K. AND KOBAYASHI, T.:
Mechanisms underlying reduced P2Y(1)-receptor-mediated relaxation in superior mesenteric arteries from
long-term streptozotocin-induced diabetic rats. Acta. Physiol , 207, 130-141 (2013)
3. NEMOTO, S., TAGUCHI, K., MATSUMOTO, T., KAMATA, K. AND KOBAYASHI, T.:
Pravastatin normalizes ET-1-induced contraction in the aorta of type 2 diabetic OLETF rats by
suppressing the KSR1/ERK complex. Am. J. Physiol. Heart Circ. Physiol , 303, H893-H902 (2012)
4. TAGUCHI, K., MORISHIGE, A., MATSUMOTO, T., KAMATA, K. AND KOBAYASHI, T.:
Enhanced estradiol-induced vasorelaxation in aortas from type 2 diabetic mice may reflect a compensatory
role of p38 MAPK-mediated eNOS activation. Pflugers. Arch , 464, 205-215 (2012)
5. TAGUCHI, K., MATSUMOTO, T., KAMATA, K. AND KOBAYASHI, T.: G protein-coupled receptor
kinase 2, with -arrestin 2, impairs insulin-induced Akt/endothelial nitric oxide synthase signaling in
ob/ob mouse aorta. Diabetes , 61, 1978-1985 (2012)
6. TAGUCHI, K., MATSUMOTO, T., KAMATA, K. AND KOBAYASHI, T.: Inhibitor of G
protein-coupled receptor kinase 2 normalizes vascular endothelial function in type 2 diabetic mice by
improving -arrestin 2 translocation and ameliorating Akt/eNOS signal dysfunction . Endocrinology , 153,
2985-2996 (2012)
7. KOBAYASHI, T., NEMOTO, S., ISHIDA, K., TAGUCHI, K., MATSUMOTO, T. AND
KAMATA, K.: Involvement of CaM kinase II in the impairment of endothelial function and eNOS activity
in aortas of Type 2 diabetic rats. Clin Sci , 123, 375-386 (2012)
8. GOULOPOULOU, S., HANNAN, J.L., MATSUMOTO, T. AND WEBB, R.C.: Pregnancy reduces
RhoA/Rho kinase and protein kinase C signaling pathways downstream of thromboxane receptor
activation in the rat uterine artery. Am. J. Physiol. Heart Circ. Physiol , 302, H2477-H2488 (2012)
9. MATSUMOTO, T., SZASZ, T., TOSTES, R.C. AND WEBB, R.C.: Impaired -adrenoceptor-induced
relaxation in small mesenteric arteries from DOCA -salt hypertensive rats is due to reduced K(Ca) channel
activity. Pharmacol. Res , 65, 537-545 (2012)
10. TAGUCHI, K., MATSUMOTO, T., KAMATA, K. AND KOBAYASHI, T.: Angiotensin II type 2
receptor-dependent increase in nitric oxide synthase activity in the endothelium of db/db mice is mediated
via a MEK pathway. Pharmacol. Res , 66, 41-50 (2012)
11. ISHIDA, K., MATSUMOTO, T., TAGUCHI, K., KAMATA, K. AND KOBAYASHI, T.: Protein
kinase C delta contributes to increase in EP3 agonist-induced contraction in mesenteric arteries from type
2 diabetic Goto-Kakizaki rats. Pflugers. Arch , 463, 593-602 (2012)
12. ISHIDA, K., MATSUMOTO, T., TAGUCHI, K., KAMATA, K. AND KOBAYASHI, T.:
Pravastatin normalizes endothelium-derived contracting factor-mediated response via suppression of
Rho-kinase signalling in mesenteric artery from aged type 2 diabetic rat . Acta. Physiol , 205, 255-265
(2012)
13. NEMOTO, S., TAGUCHI, K., MATSUMOTO, T., KAMATA, K. AND KOBAYASHI, T.:
Aminoguanidine normalizes ET-1-induced aortic contraction in type 2 diabetic Otsuka Long -Evans
Tokushima Fatty (OLETF) rats by suppressing Jab1-mediated increase in ET(A)-receptor expression.
Peptides , 33, 109-119 (2012)
14. TAGUCHI, K., MATSUMOTO, T., KAMATA, K. AND KOBAYASHI, T.: Akt/eNOS pathway
activation in endothelium-dependent relaxation is preserved in aortas from female, but not from male,
type 2 diabetic mice. Pharmacol. Res , 65, 56-65 (2012)
15. MATSUMOTO, T., TOSTES, R.C. AND WEBB, R.C.: Alterations in vasoconstrictor responses to
the endothelium-derived contracting factor uridine adenosine tetraphosphate are region specific in
DOCA-salt hypertensive rats. Pharmacol. Res , 65, 81-90 (2012)
16. MATSUMOTO, T., TOSTES, R.C. AND WEBB, R.C.: Uridine adenosine tetraphosphate-induced
contraction is increased in renal but not pulmonary arteries from deoxycorticosterone acetate -salt
hypertensive rats. Am. J. Physiol. Heart Circ. Physiol , 301, H409-H417 (2011)
17. NEMOTO, S., KOBAYASHI, T., TAGUCHI, K., MATSUMOTO, T. AND KAMATA, K.: Losartan
improves aortic endothelium-dependent relaxation via proline-rich tyrosine kinase 2/Src/Akt pathway in
type 2 diabetic Goto-Kakizaki rats. Am. J. Physiol. Heart Circ. Physiol , 301, H2383-H2394 (2011)
18. ISHIDA, K., MATSUMOTO, T., TAGUCHI, K., KAMATA, K. AND KOBAYASHI, T.:
Mechanisms underlying altered extracellular nucleotide -induced contractions in mesenteric arteries from
rats in later-stage type 2 diabetes: effect of ANG II type 1 receptor antagonism. Am. J. Physiol. Heart Circ.
Physiol , 301, H1850-H1861 (2011)
ほか
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