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医薬品、生体関連物質
9 Drugs, Metabolites
市販鎮痛解熱剤
Pain-killing drug
インドメタシン
Indometacin
1.Acetaminophen
2.Caffeine
3.Ethenzamide
4.Bromovalerylurea
1.p-Chlorobenzoic acid
2.p-Hydroxybenzoic acid n-butyl ester
3.Indometacin
2
1
3
(G900727F)
(G900727D)
Column
: YMC-Pack ODS-A (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: methanol/0.1% phosphoric acid (70/30)
Flow rate
: 1.3 mL/min
Temperature : 30 ℃
Detection
: UV at 254 nm, 0.64 AUFS
Injection
: 20 μL
Column
: YMC-Pack ODS-A (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/0.1% phosphoric acid (3/17)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 254 nm, 0.16 AUFS
Injection
: 5 μL
(日本薬局方第１２改正記載条件)
市販風邪薬成分
A cough/cold medication
風邪薬成分
Ingredients in a cough/cold medication
1.Caffeine
2.Chlorpheniramine maleate
3.Narcotine
4.Ethenzamide
5.Bucetine
1.Acetaminophen
2.Caffeine
3.Chloropheniramine malate
4.Narcotine
5.Ethenzamide
6.Bucetine
(G910523U)
(G910523E)
Column
: YMC-Pack ODS-AM (5μm, 12nm)
250 × 4.6 mm I.D.
Eluent
: acetonitrile/methanol/0.1% phosphoric acid (18/15/77)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 254 nm, 0.08 AUFS
Injection
: 3 μL (10 mg/mL)
Sample
: an extract from a commercially available cough/cold preparation
Column
: YMC-Pack ODS-AM (5μm, 12nm)
250 × 4.6 mm I.D.
Eluent
: acetonitrile/methanol/0.1% phosphoric acid (18/15/77)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 254 nm, 0.08 AUFS
Injection
: 10 μL (0.02 ∼0.22 mg/mL)
75
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医薬品、生体関連物質
医薬品、生体関連物質
9 Drugs, Metabolites
9 Drugs, Metabolites
風邪薬成分
Ingredients in a cough/cold medication
風邪薬成分
Ingredients in a cough/cold medication
1.Acetaminophen
2.Caffeine
3.Chloropheniramine malate
4.Narcotine
5.Ethenzamide
6.Bucetine
解熱鎮痛薬
Pain-killing drugs
コデイン
Codeine
1.Acetaminophen
2.Caffeine
3.Chloropheniramine malate
4.Narcotine
5.Ethenzamide
6.Bucetine
Codeine
(G910523F)
(G910523G)
(A001019B)
: YMC-Pack ODS-AM (5μm, 12nm)
150 × 6.0 mm I.D.
Eluent
: acetonitrile/methanol/0.1% phosphoric acid (18/15/77)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 254 nm, 0.08 AUFS
Injection
: 17 μL (0.02∼0.22 mg/mL)
: YMC-Pack ODS-A (5μm, 12nm)
150 × 6.0 mm I.D.
Eluent
: acetonitrile/methanol/0.1% phosphoric acid (18/15/77)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 254 nm, 0.08 AUFS
Injection
: 17 μL (0.02∼0.22 mg/mL)
: YMC-Pack Pro C4, Pro C8 and Pro C18 (5 μm,12nm)
150 × 4.6 mm I.D.
Eluent
: methanol/20mM H 3PO4 (60/40)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.32 AUFS
Injection
: 10 μL (0.01 - 2.0 mg/mL)
解熱鎮痛薬成分
Analgesics
解熱鎮痛薬成分
Analgesics
鼻炎用点鼻剤
Collunarium
Column
9
Column
Column
(J010528A)
Column
Eluent
Flow rate
Detection
Injection
塩酸ナファゾリンとマレイン酸クロルフェニラミン
Naphazoline hydrochloride and chlorpheniramine maleate
1.Naphazoline hydrochloride
2.Chlorpheniramine maleate
1
1
1
医
薬
品
・
生
体
関
連
物
質
: YMC-Pack Pro C18 (5μm,12nm)
150 × 4.6 mm I.D.
: acetonitrile/0.05% TFA (10/90)
: 1.5 mL/min
: UV at 210 nm
: 5 μL (0.1 mg/mL)
Acetaminophen
Acetaminophen
2
Naphazoline hydrochloride
2
2
Caffeine
3
Caffeine
3
Chlorpheniramine maleate
Ethenzamide
3
Ethenzamide
4
4
Apronalide
Benzethonium chloride
Apronalide
Courtesy of NIHON ARUTU PHARMACEUTICAL CO.,LTD.
(S930422D)
(S930422G)
(Y920610A)
Courtesy of NIHON ARUTU PHARMACEUTICAL CO.,LTD.
Column
: YMC-Pack ODS-A (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: methanol/water (40/60)
Flow rate
: 0.7 mL/min
Temperature : 30 ℃
Detection
: UV at 220 nm, 0.51 AUFS
Injection
: 5 μL (0.2∼2.0 mg/mL)
76
Column
: YMC-Pack C8 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: methanol/water (40/60)
Flow rate
: 0.7 mL/min
Temperature : 30 ℃
Detection
: UV at 220 nm, 0.51 AUFS
Injection
: 5 μL (0.2 ∼2.0 mg/mL)
: YMC-Pack Ph (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/water/NH4SCN (48/52/0.5, v/v/w)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 270 nm, 2.56 AUFS
Injection
: 10 μL (0.2 ∼5 mg/mL)
Sample
: collunarium
(T920526A)
Column
Column
: YMC-Pack ODS-AM (5μm, 12nm)
150 × 6.0 mm I.D.
Eluent
: acetonitrile/water/NH4 SCN (35/65/0.5, v/v/w)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 10 μL (0.125 mg/mL)
77
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医薬品、生体関連物質
医薬品、生体関連物質
9 Drugs, Metabolites
9 Drugs, Metabolites
塩化ベンゼトニウム
Benzethonium chloride
塩化ベンザルコニウム
Benzalkonium chloride
抗ヒスタミン薬
Histamine antagonists
抗ヒスタミン薬
Histamine antagonists
1.Benzethonium chloride
1.Benzalkonium chloride R=-C12H25
2.Benzalkonium chloride R=-C14H29
Courtesy of NIHON ARUTU PHARMACEUTICAL CO.,LTD.
(T920527A)
Courtesy of NIHON ARUTU PHARMACEUTICAL CO.,LTD.
(J010619A)
(T920529D)
(A980723A)
Column
: YMC-Pack ODS-AM (5μm, 12nm)
150 × 6.0 mm I.D.
Eluent
: acetonitrile/water/NH4SCN (70/30/0.5, v/v/w)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 270 nm, 0.16 AUFS
Injection
: 10 μL (1.0 mg/mL)
Column
: YMC-Pack ODS-AM (5μm, 12nm)
150 × 6.0 mm I.D.
Eluent
: acetonitrile/water/NH4SCN (70/30/0.5, v/v/w)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 260 nm, 0.02 AUFS
Injection
: 10 μL (1.0 mg/mL benzalkonium chloride)
Column
: YMC-Pack Pro C18 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 20mM KH2PO4 - K2HPO4 (pH 6.9) / methanol (35/65)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.13 AUFS
Injection
: 5 μL (0.05 - 2.0 mg/mL)
: YMC-Pack Pro C18 (3μm, 12nm)
75 × 2.0 mm I.D.
Eluent
: acetonitrile / 50mM CH3COONH4 (40/60)
Flow rate
: 0.2 mL/min
Temperature : 37℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 2 μL (0.05 - 2.0 mg/mL)
鼻炎薬成分
Ingredients in a drug for rhinitis
点眼剤成分
Ingredients in an eye drop
酸性非ステロイド性抗炎症薬
Acidic non-steroidal anti-inflammatory drugs
酸性非ステロイド性抗炎症薬
Acidic non-steroidal anti-inflammatory drugs
9
Column
医
薬
品
・
生
体
関
連
物
質
9
1
1
Piroxicam
Piroxicam
2
2
Sulindac
Sulindac
3
3
Tolmetin sodium dihydrate
Tolmetin sodium dihydrate
4
4
Ketoprofen
Ketoprofen
5
5
(J010418B)
Column
: Hydrosphere C18 (3μm, 12nm)
50 × 4.6 mm I.D.
Eluent
: A)20mM KH2PO4 - H3PO4 (pH 2.5)
B)acetonitrile
0-40%B(0-10min)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.064 AUFS
Injection
: 3 μL (0.02 - 0.5 mg/mL)
78
: Hydrosphere C18 (3μm, 12nm)
50 × 4.6 mm I.D.
Eluent
: A)20mM KH 2PO4 - H3PO4 (pH 2.5)
B)acetonitrile
0-60%B(0-10min), 60%B(10-15min)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 265 nm, 0.128 AUFS
Injection
: 5 μL (0.03 - 0.3 mg/mL)
Naproxen
Naproxen
(J010406A)
(O950126A)
Column
Column
: YMC-Pack ODS-AM (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 1-propanol/water/acetic acid (30/70/1)
Flow rate
: 0.5 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.04 AUFS
Injection
: 3 μL (20 μg/mL)
(O950124A)
Column
: J'sphere ODS-H80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: 2-propanol/water/acetic acid (25/75/1)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.04 AUFS
Injection
: 5 μL (20 μg/mL)
79
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医薬品、生体関連物質
医薬品、生体関連物質
9 Drugs, Metabolites
9 Drugs, Metabolites
酸性非ステロイド性抗炎症薬
Acidic non-steroidal anti-inflammatory drugs
酸性非ステロイド性抗炎症薬
Acidic non-steroidal anti-inflammatory drugs
三環系抗うつ薬
Tricyclic antidepressants
1
1
三環系抗うつ薬
Tricyclic antidepressants
1
Ketoprofen
Fenoprofen calcium dihydrate
Desipramine hydrochloride
2
2
2
Flurbiprofen
Fenoprofen calcium dihydrate
Acenaphthene (I.S.)
3
3
3
Ibuprofen
Flurbiprofen
Imipramine hydrochloride
4
4
Ibuprofen
Amitriptyline hydrochloride
(O950125C)
(A970321A)
Column
: J'sphere ODS-H80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: methanol/water/acetic acid (65/35/1)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.04 AUFS
Injection
: 7 μL (160, 16, 820 μg/mL)
Column
: YMC-Pack ODS-A (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: methanol/water/acetic acid (65/35/1)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.032 AUFS
Injection
: 7 μL (6∼820 μg/mL)
: YMC-Pack ODS-AM (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 20mM KH2PO4 - K2HPO4 (pH 6.9)/methanol (25/75)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.16 AUFS
Injection
: 5 μL (0.1∼0.5 mg/mL)
三環系抗うつ薬
Tricyclic antidepressants
三環系抗うつ薬
Tricyclic antidepressants
抗精神病薬
Antipsychotic drugs
Column
1
2
9
(A980827E)
(A961016B)
Column
: YMC-Pack Pro C18 (3μm, 12nm)
75 × 4.6 mm I.D.
Eluent
: methanol / 20mM CH3 COONH4 (75/25)
Flow rate
: 1.0 mL/min
Temperature : 37℃
Detection
: UV at 254 nm, 0.32 AUFS
Injection
: 5 μL (0.1-0.5 mg/mL)
抗てんかん薬
Antiepileptics
Perphenazine
9
1
1
1
医
薬
品
・
生
体
関
連
物
質
Prochlorperazine maleate
3
Ethosuximide
Doxepin hydrochloride
2
Desipramine hydrochloride
Promazine hydrochloride
4
2
2
Primidone
Fluphenazine hydrochloride
5
Desipramine hydrochloride
Acenaphthene
3
(I.S.)
3
Trifluoperazine hydrochloride
3
6
Phenobarbital sodium salt
4
Ethopropazine hydrochloride
Imipramine hydrochloride
7 (Profenamine hydrochloride)
Imipramine hydrochloride
4
Phenytoin
4
8
5
Chlorpromazine hydrochloride
Amitriptyline hydrochloride
Amitriptyline hydrochloride
Carbamazepine
Thioridazine hydrochloride
(D960724A)
Column
: YMC-Pack Pro C18 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/50mM NH4H2PO4 (30/70)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 215 nm, 0.13 AUFS
Injection
: 2 μL (0.125 mg/mL)
80
(A961015G)
Column
: YMC-Pack Pro C18 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 20mM KH2PO4 - K2HPO4 (pH 6.9)/methanol (25/75)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.16 AUFS
Injection
: 5 μL (0.1∼0.5 mg/mL)
(O950627B)
Column
: J'sphere ODS-H80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: acetonitrile/water/TFA (30/70/0.1)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.064 AUFS
Injection
: 5 μL (0.02 mg/mL)
(S960723A)
Column
: YMC-Pack Pro C18 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 50mM NH4 H2 PO4 - (NH4 )2 HPO4 (pH 6.7)/methanol (50/50)
Flow rate
: 0.7 mL/min
Temperature : 37 ℃
Detection
: UV at 215 nm, 0.32 AUFS
Injection
: 8 μL (0.035 ∼0.7 mg/mL)
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医薬品、生体関連物質
医薬品、生体関連物質
9 Drugs, Metabolites
9 Drugs, Metabolites
抗高脂血症剤
Hypolipidemic drugs
抗高脂血症剤
Hypolipidemic drugs
カルシウム拮抗薬
Calcium antagonists
カルシウム拮抗薬
Calcium antagonists
5
1
5
1
1
1
Prenylamine lactate
Prenylamine lactate
Diltiazem HCl
Diltiazem HCl
Bezafibrate
Bezafibrate
2
6
Bepridil HCl
2
2
Bepridil HCl
Verapamil HCl
Verapamil HCl
7
3
7
3
Gemfibrozil
Gemfibrozil
6
2
Methoxyverapamil HCl
Methoxyverapamil HCl
3
3
Niguldipine HCl
Niguldipine HCl
4
4
8
8
Clofibrate
Clofibrate
Nicardipine HCl
Nicardipine HCl
4
4
Nifedipine
Nifedipine
Fenofibrate
Fenofibrate
(S930702C)
(S930706E)
(S930701D)
(S930706C)
Column
Column
: J'sphere ODS-H80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/water/acetic acid(60/40/1)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 275 nm, 0.064 AUFS
Injection
: 8 μL (0.05∼0.25 mg/mL)
: J'sphere ODS-M80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/water/acetic acid(60/40/1)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 275 nm, 0.064 AUFS
Injection
: 8 μL (0.05∼0.25 mg/mL)
: J'sphere ODS-H80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: 20mM KH2 PO4 - H3PO4 (pH 3.0)/acetonitrile/THF/TBA･Br
(75/15/10/0.5, v/v/v/w)
Flow rate
: 0.8 mL/min
Temperature : 30 ℃
Detection
: UV at 270 nm, 0.064 AUFS
Injection
: 8 μL (0.05 ∼1.4 mg/mL)
: J'sphere ODS-M80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: 20mM KH2 PO4 - H3PO4 (pH 3.0)/acetonitrile/THF/TBA･Br
(70/20/10/0.35, v/v/v/w)
Flow rate
: 0.8 mL/min
Temperature : 30 ℃
Detection
: UV at 270 nm, 0.064 AUFS
Injection
: 8 μL (0.05 ∼1.4 mg/mL)
抗高脂血症剤
Hypolipidemic drugs
ロバスタチン
Lovastatin
カルシウム拮抗薬
Calcium antagonists
不整脈治療薬
Antiarrhythmic drugs
Column
1
9
Column
5
9
1
Prenylamine lactate
医
薬
品
・
生
体
関
連
物
質
Bezafibrate
Diltiazem HCl
2
6
2
Bepridil HCl
Verapamil HCl
Gemfibrozil
7
3
Lovastatin
3
Methoxyverapamil HCl
4
Niguldipine HCl
8
Clofibrate
Nicardipine HCl
4
Nifedipine
Fenofibrate
(S930702A)
(S930706B)
(J010528B)
(S990819B)
: J'sphere ODS-L80 (4 μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: 20mM KH2 PO4 - H3PO4 (pH 3.0)/acetonitrile/THF/TBA･Br
(70/20/10/0.35, v/v/v/w)
Flow rate
: 0.8 mL/min
Temperature : 30 ℃
Detection
: UV at 270 nm, 0.064 AUFS
Injection
: 8 μL (0.05∼1.4 mg/mL)
Column
Column
: J'sphere ODS-L80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/water/acetic acid(60/40/1)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 275 nm, 0.064 AUFS
Injection
: 8 μL (0.05∼0.25 mg/mL)
82
Column
Eluent
Flow rate
Detection
Injection
: YMC-Pack Pro C18 (5 μm,12nm)
150 × 4.6 mm I.D.
: acetonitrile/0.05% formic acid (30/70)
: 1.5 mL/min
: UV at 240 nm
: 5 μL (0.1 mg/mL)
Column
: YMC-Pack Pro C18 (5μm, 12nm)
250 × 4.6 mm I.D.
Eluent
: 20mM KH2PO4 - K2HPO4 (pH 6.9) / methanol (30/70)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 220 nm, 0.26 AUFS
Injection
: 5 μL (0.05 - 0.1 mg/mL)
83
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医薬品、生体関連物質
医薬品、生体関連物質
9 Drugs, Metabolites
9 Drugs, Metabolites
不整脈治療薬
Antiarrhythmic drugs
局所麻酔薬
Local anesthetics
利尿薬
Diuretics
制がん剤および関連化合物
Antineoplastic and related compounds
1
Uracil
2
5-Fluorouracil
3
Deoxyuridine
4
5-Fluoro-2'-deoxyuridine
(S990817C)
(J010302E)
(A980716A)
(T920924E)
Column
: YMC-Pack Pro C4 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 20mM KH2 PO4 - K2HPO4 (pH 6.9) / methanol (40/60)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 220 nm, 0.26 AUFS
Injection
: 5 μL (0.05 - 0.1 mg/mL)
Column
: Hydrosphere C18 (3μm, 12nm)
75 × 4.6 mm I.D.
Eluent
: 20mM KH2PO4 - K2HPO4 (pH 6.9) / methanol (40/60)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.16 AUFS
Injection
: 10 μL (0.02 - 0.5 mg/mL)
Column
: YMC-Pack Pro C18 (3μm, 12nm)
75 × 2.0 mm I.D.
Eluent
: methanol / 1% acetic acid (40/60)
Flow rate
: 0.2 mL/min
Temperature : 37 ℃
Detection
: UV at 280 nm, 0.08 AUFS
Injection
: 3 μL (0.015 - 0.2 mg/mL)
: YMC-Pack ODS-A (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 10mM NH4H2PO4
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.16 AUFS
Injection
: 10 μL (0.025∼0.2 mg/mL)
利尿薬
Diuretics
利尿薬
Diuretics
制がん剤および関連化合物
Antineoplastic and related compounds
葉酸及び葉酸拮抗物質
Folic acid and its antagonists
9
1
1
医
薬
品
・
生
体
関
連
物
質
Column
9
1
1
Uracil
Aminopterin
2
Hydrochlorothiazide
2
Hydrochlorothiazide
2
2
5-Fluorouracil
Methotrexate
3
3
Chlorthalidone
Chlorthalidone
Folic acid
3
Deoxyuridine
3
4
Furosemide
Furosemide
5-Fluoro-2'-deoxyuridine
(A970425C)
Column
: YMC-Pack Pro C18 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 20mM NH 4H2PO4 - H3PO4(pH 3.2)/methanol (60/40)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 280 nm, 0.16 AUFS
Injection
: 15 μL (0.015∼0.2mg/mL)
84
(A970426D)
Column
: YMC-Pack ODS-AQ (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 20mM NH4 H2 PO4 - H3PO4(pH 3.2)/methanol (60/40)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 280 nm, 0.16 AUFS
Injection
: 15 μL (0.015∼0.2mg/mL)
(T920924G)
Column
: YMC-Pack ODS-AQ (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 10mM NH 4H2PO4
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.16 AUFS
Injection
: 10 μL (0.025∼0.2 mg/mL)
(O950411B)
Column
: J'sphere ODS-M80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: methanol/water/acetic acid (20/80/1)
Flow rate
: 1.0 mL/min
Temperature : ambient(25 ℃)
Detection
: UV at 300 nm, 0.04 AUFS
Injection
: 5 μL (16 μg/mL)
85
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医薬品、生体関連物質
医薬品、生体関連物質
9 Drugs, Metabolites
9 Drugs, Metabolites
抗ＨＩＶヌクレオシド誘導体
Anti-human immunodeficiency virus (HIV) agents
抗ＨＩＶヌクレオシド誘導体
Anti-human immunodeficiency virus (HIV) agents
ニコチン酸構造類縁体
Nicotinic acid analogues
塩基性化合物
Basic compounds
1
1
Uracil
1
Isonicotinic acid
1
2
2
Procainamide
DDC
DDC
3
Nicotinic acid
2
2
N-Acetylprocainamide
3
DDI
4
DDI
Isonicotinic acid hydrazide
4'-Hydroxyacetophenone
3
4
3
D4T
Nicotinamide
D4T
4
5
4
N' -Methylnicotinamide
AZT
AZT
(K930311C)
(K930311A)
(K940125K)
(T931217C)
Column
: YMC-Pack ODS-A (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: methanol/10mM KH2PO4 (10/60)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.16 AUFS
Injection
: 7 μL (0.125 mg/mL)
Column
: YMC-Pack C8 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: methanol/10mM KH2PO4 (10/60)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.16 AUFS
Injection
: 7 μL (0.125 mg/mL)
Column
: YMC-Pack C8 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/20mM KH2PO4 (5/95)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 260 nm, 0.64 AUFS
Injection
: 13 μL (0.2 mg/mL)
Column
: YMC-Pack ODS-AM (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 20mM K2HPO4 - KH2PO4 (pH 6.9)/acetonitrile (92/8)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.32 AUFS
Injection
: 10 μL (30∼300 μg/mL)
抗ＨＩＶヌクレオシド誘導体
Anti-human immunodeficiency virus (HIV) agents
ニコチン酸構造類縁体
Nicotinic acid analogues
塩基性化合物
Basic compounds
殺菌薬
Disinfectants
1
9
医
薬
品
・
生
体
関
連
物
質
Benzoic acid
Uracil
2
Isonicotinic acid
1
9
1
1
2
2
Procainamide
Salicylic acid
3
DDC
Nicotinic acid
3
2
3
N-Acetylprocainamide
4
Theophylline (I.S.)
DDI
Isonicotinic acid hydrazide
4
4'-Hydroxyacetophenone
4
Phenol
3
Nicotinamide
D4T
5
4
N' -Methylnicotinamide
AZT
(S930617D)
(K930311F)
(K940125I)
(T931217B)
Column
Column
: YMC-Pack C4 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: methanol/10mM KH2PO4 (10/60)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.16 AUFS
Injection
: 7 μL (0.125 mg/mL)
86
Column
: YMC-Pack ODS-A (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/20mM KH2PO4 (5/95)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 260 nm, 0.64 AUFS
Injection
: 13 μL (0.2 mg/mL)
Column
: YMC-Pack PolymerC18
150 × 4.6 mm I.D.
Eluent
: 20mM K2 HPO4 - KH2PO4 (pH 6.9)/acetonitrile (92/8)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.32 AUFS
Injection
: 10 μL (30∼300 μg/mL)
: YMC-Pack ODS-AL (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 100mM KH2PO4 - Na2HPO4 (pH 7.0)/methanol (75/25)
Flow rate
: 0.8 mL/min
Temperature : 30 ℃
Detection
: UV at 270 nm, 0.13 AUFS
Injection
: 3 μL (0.1∼0.8 mg/mL)
日本薬局方第１２改正記載条件
87
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医薬品、生体関連物質
医薬品、生体関連物質
9 Drugs, Metabolites
9 Drugs, Metabolites
アシクロビル
Acyclovir
塩化カルニチン
Carnitine chloride
プリン代謝物
Purine catabolites
プリン代謝物
Purine catabolites
1.Allantoin
2.Allantoic acid
3.Uric acid
1.Allantoin
2.Allantoic acid
3.Uric acid
Acyclovir
(F000629A)
(J010528C)
Column
Eluent
Flow rate
Detection
Injection
: Hydrosphere C18 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 50mM NaH2PO4-H3PO4 (pH2.6)
containing 15mM 1-pentanesulfonic acid sodium salt
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 210 nm, 0.064 AUFS
Injection
: 4 μL (0.2 ∼20 mg/mL)
(G910607G)
(G910618A)
Column
: YMC-Pack Pro C18 (5μm, 12nm)
150 × 4.6 mm I.D.
: acetonitrile / 0.05% formic acid (3 / 97)
: 1.5 mL/min
: UV at 254 nm
: 5μL (0.1 mg/mL)
キサンチンオキシダーゼ阻害剤および関連化合物
Xanthine oxidase inhibitor and related compounds
9
キサンチンオキシダーゼ阻害剤および関連化合物
Xanthine oxidase inhibitor and related compounds
Column
: YMC-Pack ODS-AM (5μm, 12nm)
150 × 6.0 mm I.D.
Eluent
: 10mM CH 3COOH
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 200 nm, 0.16 AUFS
Injection
: 4 μL (0.10 ∼0.71 mg/mL)
Column
: YMC-Pack ODS-AQ (5μm, 12nm)
150 × 6.0 mm I.D.
Eluent
: 10mM CH3COOH
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 200 nm, 0.16 AUFS
Injection
: 4 μL (0.10 ∼0.71 mg/mL)
カテコールアミン
Catecholamines
馬尿酸類
Hippuric and methylhippuric acids
1
医
薬
品
・
生
体
関
連
物
質
9
1
1
1. Norepinephrine hydrochloride
2. Epinephrine
3. 3,4-Dihydroxyphenylalanine
(DOPA)
4. Dopamine hydrochloride
5. 4-Hydroxy-3-methoxymandelic acid
6. 3-Methoxytyramine hydrochloride
7. 4-Hydroxy-3-methoxyphenylglycol
8. 3,4-Dihydroxyphenylacetic acid
9. Homovanilic acid
Uric acid
Uric acid
2
2
Hypoxanthine
Hypoxanthine
3
Mandelic acid
2
Hippuric acid
3
3
Xanthine
o-Methylhippuric acid
Xanthine
4
4
4
Oxipurinol
m-Methylhippuric acid
Oxipurinol
5
5.
5
Allopurinol
Allopurinol
p-Methylhippuric acid
(F000817A)
(S930728J)
Column
: J'sphere ODS-M80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: 50mM NH 4H2PO4
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.51 AUFS
Injection
: 8 μL (0.05∼0.2 mg/mL)
88
(S930729B)
: J'sphere ODS-L80 (4 μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: 50mM NH4H2PO4
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.51 AUFS
Injection
: 8 μL (0.05 ∼0.2 mg/mL)
Column
: Hydrosphere C18 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: A)50mM KH2PO4-H3 PO4(pH 3.1)
B)50mM KH2PO4-H3 PO4(pH 3.1)/acetonitrile (90/10)
0%B (0-5min), 0-100%B (5-25min,linear), 100%B (25-35min)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 280 nm, 0.64 AUFS
Injection
: 10 μL (0.15 - 0.25 mg/mL)
(A961114A)
Column
Column
: YMC-Pack Pro C18 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 20mM NH4H2PO4 - H3PO4 (pH 3.2)/methanol (80/20)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 225 nm, 0.16 AUFS
Injection
: 10 μL (0.04 ∼0.07 mg/mL)
89
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医薬品、生体関連物質
抗菌剤、抗生物質
9 Drugs, Metabolites
10 Antibiotics
馬尿酸類
Hippuric and methylhippuric acids
合成抗菌剤
Antibacterial agents
合成抗菌剤
Antibacterial agents
1. Olaquindox
2. Carbadox
3. Thiamphenicol
4. Sulfamerazine
5. Sulfadimidine
6. Sulfamonomethoxine
7. Furazolidone
8. Oxolinic acid
9. Sulfaquinoxaline
10. Sulfadimethoxine
11. Nalidixic acid
12. Piromidic acid
1
Mandelic acid
2
Hippuric acid
1. Olaquindox
2. Carbadox
3. Thiamphenicol
4. Sulfamerazine
5. Sulfadimidine
6. Sulfamonomethoxine
7. Furazolidone
8. Oxolinic acid
9. Sulfaquinoxaline
10. Sulfadimethoxine
11. Nalidixic acid
12. Piromidic acid
3
o-Methylhippuric acid
4
m-Methylhippuric acid
5
p-Methylhippuric acid
(K940614B)
(A961119A)
Column
: J'sphere ODS-M80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: 20mM NH4H2 PO4 - H3PO4 (pH 3.2)/methanol (80/20)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 225 nm, 0.16 AUFS
Injection
: 10 μL (0.04∼0.07 mg/mL)
(K940615C)
Column
: YMC-Pack ODS-A (5μm, 12nm)
250 × 4.6 mm I.D.
Eluent
: A)acetonitrile/50mM NH4H2PO4 (10/90)
B)acetonitrile/50mM NH4 H2 PO4 (80/20)
25%B (0-5min), 25-100%B (5-15min), 100%B (15-20min)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 240 nm, 0.32 AUFS
Injection
: 10 μL (0.05 mg/mL)
: J'sphere ODS-L80 (4μm, 8nm)
250 × 4.6 mm I.D.
Eluent
: A)acetonitrile/50mM NH4 H2 PO4 (10/90)
B)acetonitrile/50mM NH4H2PO4 (80/20)
25%B (0-5min), 25-100%B (5-15min), 100%B (15-20min)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 240 nm, 0.32 AUFS
Injection
: 10 μL (0.05 mg/mL)
合成抗菌剤
Antibacterial agents
サルファ剤
Sulfonamides
9
Column
1
1
6
Sulfaguanidine
医
薬
品
・
生
体
関
連
物
質
2
7
Sulfapyridine
Diaveridine
Sulfanilamide
2
3
Trimethoprim
4
8
Sulfisomidine
9
Sulfamerazine
10
Sulfamethizole
3
Sulfathiazole
5
Pyrimethamine
10
Sulfadiazine
(O950320G)
Column
: J'sphere ODS-M80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: acetonitrile/50mM NH4H2PO4 (15/85)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 230 nm, 0.16 AUFS
Injection
: 5 μL (20 μg/mL)
90
Sulfamethoxypyridazine
Sulfamethazine
(O950306E)
Column
: J'sphere ODS-M80 (4μm, 8nm)
250 × 4.6 mm I.D.
Eluent
: THF/50mM NH4H2PO4 (10/90)
Flow rate
: 0.5 mL/min
Temperature : 37 ℃
Detection
: UV at 275 nm, 0.16 AUFS
Injection
: 3 μL (50 μg/mL)
91
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抗菌剤、抗生物質
抗菌剤、抗生物質
10 Antibiotics
10 Antibiotics
サルファ剤
Sulfonamides
サルファ剤
Sulfonamides
1
サルファ剤
Sulfonamides
1
6
抗生物質
Antibiotics
1.Ampicilline
2.Cephalexin
3.Oxytetracycline hydrochloride
4.Tetracycline
5.Chlorotetracycline
6.Chloramphenichol
7.Oxolinic acid
8.Doxorubicin hydrochloride
9.Nalidixic acid
Sulfamethazine
2
Sulfaguanidine
2
Sulfathiazole
7
Sulfadoxine
3
Sulfamethizole
3
Trimethoprim
8
Sulfamonomethoxine hydrate
4
4
Sulfapyridine
Sulfanilamide
9
Sulfamerazine
Sulfisomidine
5
5
10
Sulfamethoxypyridazine
Sulfadiazine
6
11
Sulfisoxazole
Sulfamethoxazole
Sulfachloropyridazine
Sulfamethazine
7
8
Sulfadimethoxine
(G910523M)
Sulfaquinoxaline sodium
(J010130D)
(O950324L)
(O950302C)
Column
Column
: J'sphere ODS-H80 (4μm, 8nm)
250 × 4.6 mm I.D.
Eluent
: 50mM NH4H2PO4 - (NH4)2HPO 4 (pH 6.2)/THF (90/10)
Flow rate
: 0.5 mL/min
Temperature : 37 ℃
Detection
: UV at 275 nm, 0.16 AUFS
Injection
: 10 μL (18 μg/mL)
: YMC-Pack ODS-A (5μm, 12nm)
250 × 4.6 mm I.D.
Eluent
: THF/water/acetic acid (30/70/1)
Flow rate
: 0.5 mL/min
Temperature : 37 ℃
Detection
: UV at 275 nm, 0.16 AUFS
Injection
: 5 μL (42 μg/mL)
: Hydrosphere C18 (3μm, 12nm)
75 × 2.0 mm I.D.
Eluent
: 10mM CH 3COOH - CH3COONH4 (pH 4.6) / acetonitrile
(85/15)
Flow rate
: 0.2 mL/min
Temperature : 37 ℃
Detection
: UV at 275 nm, 0.16 AUFS
Injection
: 2 μL (0.02 mg/mL)
サルファ剤
Sulfonamides
サルファ剤
Sulfonamides
ナリジクス酸系抗生物質
Nalidixic acid antibiotics
Column
1
6
1
Column
: YMC-Pack ODS-AM (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: A)acetonitrile/50mM NH4H2PO4 (10/90)
B)acetonitrile/50mM NH4H2PO4 (50/50)
0-55%B (0-30min,linear), 55%B (30-40min)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 250 nm, 0.16 AUFS
Injection
: 15 μL (0.01 ∼0.15 mg/mL)
ナリジクス酸系抗生物質
Nalidixic acid antibiotics
Pipemidic acid
Pipemidic acid
2
Sulfisomidine
2
Sulfamonomethoxine hydrate
7
2
Enoxacin
Enoxacin
3
Sulfathiazole
10
3
Sulfadoxine
8
3
Cinoxacin
抗
菌
剤
・
抗
生
物
質
4
Sulfamethoxazole
9
4
Norfloxacin
Norfloxacin
5
Sulfamerazine
5
5
Sulfadimethoxine
10
Ofloxacin
Ofloxacin
6
Sulfamethazine
10
Cinoxacin
4
Sulfadiazine
1
6
Sulfaquinoxaline sodium
Nalidixic acid
Nalidixic acid
7
7
Oxolinic acid
Oxolinic acid
8
8
Piromidic acid
Piromidic acid
(O950428A)
(J010321F)
(O950428D)
(O950217D)
Column
Column
: J'sphere ODS-M80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: THF/acetonitrile/50mM NH4H2PO4 (15/5/80)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 275 nm, 0.16 AUFS
Injection
: 3 μL (50 μg/mL)
92
: Hydrosphere C18 (3μm, 12nm)
50 × 4.6 mm I.D.
Eluent
: 10mM CH 3COOH - CH3COONH4 (pH 4.6) / acetonitrile
(85/15)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 275 nm, 0.16 AUFS
Injection
: 10 μL (0.01 - 0.04 mg/mL)
Column
: J'sphere ODS-H80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: 50mM NH4H2PO4 - (NH4)2HPO4 (pH 6.7)/tetrahydrofuran (90/10)
containing 20mM TBA･Br
Flow rate
: 1.0 mL/min
Temperature : ambient (25 ℃)
Detection
: UV at 260 nm, 0.32 AUFS
Injection
: 5 μL (0.03 mg/mL)
Column
: YMC-Pack ODS-AM (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 50mM NH4 H2 PO4 - (NH4)2 HPO4 (pH 6.7)/tetrahydrofuran (90/10)
containing 20mM TBA･Br
Flow rate
: 1.0 mL/min
Temperature : ambient (25 ℃)
Detection
: UV at 260 nm, 0.32 AUFS
Injection
: 5 μL (0.03 mg/mL)
93
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抗菌剤、抗生物質
抗菌剤、抗生物質
10 Antibiotics
10 Antibiotics
ナリジクス酸系抗生物質
Nalidixic acid antibiotics
ナリジクス酸系抗生物質
Nalidixic acid antibiotics
セフェム系抗生物質
Cephalosporin antibiotics
セフェム系抗生物質
Cephalosporin antibiotics
1. Cefsulodin sodium
2. Cephalexin hydrate
3. Cefaclor
4. Cephradine
5. Cephaloglycin
6. Cephapirin sodium
7. Cefotaxime sodium
8. Cephaloridine
9. Cefazolin sodium
10. Cefuroxime sodium
11. Cefoxitin sodium
1
Cefadroxil
2
Cephalosporin C potassium
3
Cefatrizine propylene glycol
4
Cephalexin hydrate
5
Cephaloridine
(A010324A)
(A010324C)
(O940718B)
(O940927B)
Column
: Hydrosphere C18 (3μm, 12nm)
50 × 2.0 mm I.D.
Eluent
: acetonitrile / 50mM NaH2PO4 (25/75)
Flow rate
: 0.2 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.128 AUFS
Injection
: 1 μL (0.02 - 0.1 mg/mL)
: Hydrosphere C18 (3μm, 12nm)
50 × 2.0 mm I.D.
Eluent
: 10mM CH3COOH - CH3COONH4(pH 4.3) / acetonitrile
(75/25)
Flow rate
: 0.2 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.128 AUFS
Injection
: 1 μL (0.02 - 0.1 mg/mL)
Column
: J'sphere ODS-L80 (4μm, 8nm)
250 × 4.6 mm I.D.
Eluent
: acetonitrile/100mM KH2 PO4 (10/90)
Flow rate
: 0.8 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 5 μL (0.12 ∼0.35 mg/mL)
: J'sphere ODS-H80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: methanol/water/acetic acid (10/85/5)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 6 μL (0.2 mg/mL)
セフェム系抗生物質
Cephalosporin antibiotics
セフェム系抗生物質
Cephalosporin antibiotics
セフェム系抗生物質
Cephalosporin antibiotics
セフェム系抗生物質
Cephalosporin antibiotics
Column
1. Cefsulodin sodium
2. Cephalexin hydrate
3. Cefaclor
4. Cephradine
5. Cephaloglycin
6. Cephapirin sodium
7. Cefotaxime sodium
8. Cephaloridine
9. Cefazolin sodium
10. Cefuroxime sodium
11. Cefoxitin sodium
10
抗
菌
剤
・
抗
生
物
質
1. Cefsulodin sodium
2. Cephalexin hydrate
3. Cefaclor
4. Cephradine
5. Cephaloglycin
6. Cephapirin sodium
7. Cefotaxime sodium
8. Cephaloridine
9. Cefazolin sodium
10. Cefuroxime sodium
11. Cefoxitin sodium
Column
1
1
Cefadroxil
Cefadroxil
2
Cephalosporin C potassium
3
Cefatrizine propylene glycol
4
Cephalexin hydrate
5
2
10
Cephalosporin C potassium
3
Cefatrizine propylene glycol
4
Cephalexin hydrate
5
Cephaloridine
Cephaloridine
(O940719A)
Column
: J'sphere ODS-H80 (4μm, 8nm)
250 × 4.6 mm I.D.
Eluent
: acetonitrile/100mM KH2PO4 (10/90)
Flow rate
: 0.8 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 5 μL (0.12∼0.35 mg/mL)
94
(O940715F)
Column
: J'sphere ODS-M80 (4μm, 8nm)
250 × 4.6 mm I.D.
Eluent
: acetonitrile/100mM KH2 PO4 (10/90)
Flow rate
: 0.8 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 5 μL (0.12 ∼0.35 mg/mL)
(O940927C)
Column
: J'sphere ODS-M80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: methanol/water/acetic acid (10/85/5)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 6 μL (0.2 mg/mL)
(O940927I)
Column
: J'sphere ODS-L80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: methanol/water/acetic acid (10/85/5)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 6 μL (0.2 mg/mL)
95
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抗菌剤、抗生物質
抗菌剤、抗生物質
10 Antibiotics
10 Antibiotics
セフェム系抗生物質
Cephalosporin antibiotics
セフェム系抗生物質
Cephalosporin antibiotics
セフェム系抗生物質
Cephalosporin antibiotics
セフェム系抗生物質
Cephalosporin antibiotics
1
1
1
1
Cefadroxil
Cefadroxil
2
2
Cefoperazone sodium
Cefoperazone sodium
Cephalosporin C potassium
Cephalosporin C potassium
3
Cefatrizine propylene glycol
4
2
2
3
Cephalothin sodium
Cephalothin sodium
Cefatrizine propylene glycol
4
3
3
Cephalexin hydrate
5
Cephalexin hydrate
Cefamandole sodium
5
Cefamandole sodium
Cephaloridine
Cephaloridine
(O940927G)
(O941025E)
(O940928R)
(O940929D)
Column
: YMC-Pack ODS-AQ (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: methanol/water/acetic acid (10/85/5)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 6 μL (0.2 mg/mL)
Column
: YMC-Pack ODS-AM (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: methanol/water/acetic acid (10/85/5)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 6 μL (0.2 mg/mL)
Column
: J'sphere ODS-L80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: THF/50mM NH4H2PO4 (15/85)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 6 μL (0.17 mg/mL)
: J'sphere ODS-H80 (4μm, 8nm)
75 × 2.0 mm I.D.
Eluent
: THF/50mM NH4H2PO4 (15/85)
Flow rate
: 0.2 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 3 μL (0.17 mg/mL)
セフェム系抗生物質
Cephalosporin antibiotics
セフェム系抗生物質
Cephalosporin antibiotics
セフェム系抗生物質
Cephalosporin antibiotics
セフェム系抗生物質
Cephalosporin antibiotics
1
1
Column
1
1
Ceftriaxone sodium
10
10
2
2
2
2
抗
菌
剤
・
抗
生
物
質
Cefoperazone sodium
Cefoperazone sodium
Cefoperazone sodium
Cefotaxime sodium
Cephalothin sodium
Cephalothin sodium
Cephalothin sodium
3
3
3
(O940928P)
Column
: J'sphere ODS-H80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: THF/50mM NH4H2PO4 (15/85)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 6 μL (0.17 mg/mL)
96
Cefamandole sodium
Cefamandole sodium
Cefamandole sodium
(O940928Q)
Column
: J'sphere ODS-M80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: THF/50mM NH 4H2PO4 (15/85)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 6 μL (0.17 mg/mL)
(O940928S)
Column
: YMC-Pack ODS-A (3μm, 12nm)
50 × 4.6 mm I.D.
Eluent
: THF/50mM NH 4H2PO4 (15/85)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 6 μL (0.17 mg/mL)
(O940928G)
Column
: J'sphere ODS-H80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: methanol/50mM NH4H2PO4 (30/70)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 5 μL (0.08, 0.16 mg/mL)
97
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抗菌剤、抗生物質
抗菌剤、抗生物質
10 Antibiotics
10 Antibiotics
セフェム系抗生物質
Cephalosporin antibiotics
セフェム系抗生物質
Cephalosporin antibiotics
セファロスポリンC
Cephalosporin C
セフトリアキソン
Ceftriaxone
1
1
Ceftriaxone sodium
Ceftriaxone sodium
2
2
Cefotaxime sodium
Cefotaxime sodium
(O940928F)
(O940929K)
(S000714B)
(S000726B)
Column
: J'sphere ODS-M80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: methanol/50mM NH4H2PO4 (30/70)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 5 μL (0.08, 0.16 mg/mL)
Column
: J'sphere ODS-H80 (4μm, 8nm)
75 × 2.0 mm I.D.
Eluent
: methanol/50mM NH4 H2PO4 (30/70)
Flow rate
: 0.2 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 3 μL (0.08, 0.16 mg/mL)
Column
: Hydrosphere C18 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/20mM KH2PO4 (5/95)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 10 μL (0.2 mg/mL)
Column
: Hydrosphere C18 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: methanol / 10mM H3PO4 (25/75)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.32 AUFS
Injection
: 10 μL (0.1, 0.4 mg/mL)
セフェム系抗生物質
Cephalosporin antibiotics
セフェム系抗生物質
Cephalosporin antibiotics
セフォキシチンナトリウム
Cefoxitin sodium
セフォキシチンナトリウム
Cefoxitin sodium
1
1
1
10
Caffeine (I.S.)
Cephaloglycin
Caffeine (I.S.)
2
抗
菌
剤
・
抗
生
物
質
Cefoxitin sodium
Cefotaxime sodium
10
2
2
Cefoxitin sodium
3
Cephapirin sodium
(O940720A)
Column
: J'sphere ODS-M80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: acetonitrile/100mM KH2 PO4 (10/90)
Flow rate
: 0.8 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.64 AUFS
Injection
: 5 μL (0.5 mg/mL)
98
(S000717B)
Column
: Hydrosphere C18 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/20mM KH2PO4 (10/90)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.32 AUFS
Injection
: 15 μL (0.1∼0.2 mg/mL)
(O940728M)
Column
: J'sphere ODS-H80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: acetonitrile/50mM KH2 PO4 (20/80)
Flow rate
: 1.8 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.32 AUFS
Injection
: 1.2 μL (8, 12 mg/mL)
(O940728P)
Column
: J'sphere ODS-H80 (4μm, 8nm)
75 × 2.0 mm I.D.
Eluent
: acetonitrile/50mM KH2PO4 (20/80)
Flow rate
: 0.34 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.32 AUFS
Injection
: 1.2 μL (1.6, 2.4 mg/mL)
99
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抗菌剤、抗生物質
抗菌剤、抗生物質
10 Antibiotics
10 Antibiotics
セフォキシチンナトリウム
Cefoxitin sodium
ペニシリン系抗生物質
Penicillin antibiotics
エリスロマイシン
Erythromycin antibiotic drugs
1
2
テトラサイクリン系抗生物質
Tetracycline antibiotics
Bacampicillin hydrocloride
1.Erythromycin
2.Erythromycin ethylsuccinate
3.Erythromycin estolate
1
1
Methicillin sodium
3
Caffeine (I.S.)
4
Penicillin G potassium
(Benzylpenicillin potassium)
Oxytetracycline hydrochloride
2
2
5
Penicillin V potassium
(Phenoxymethylpenicillin potassium)
Tetracycline hydrochloride
Cefoxitin sodium
Phenethicillin potassium
6 (Phenoxyethylpenicillin potassium)
7 Cloxacillin sodium
8
Propicillin potassium
Dicloxacillin sodium
(O940729A)
(O950908A)
(S930910B)
(S970524D)
Column
: J'sphere ODS-H80 (4μm, 8nm)
150 × 2.0 mm I.D.
Eluent
: acetonitrile/50mM KH2PO4 (20/80)
Flow rate
: 0.34 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.32 AUFS
Injection
: 1.2 μL (1.6, 2.4 mg/mL)
Column
: J'sphere ODS-H80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: 50mM NaH2PO4 - H3PO4 (pH 2.3)/acetonitrile (67/33)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 220 nm, 0.26 AUFS
Injection
: 8 μL (0.13 mg/mL)
Column
: J'sphere ODS-H80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/methanol/100mM (NH4)2HPO4(45/15/40)
Flow rate
: 1.0 mL/min
Temperature : 45 ℃
Detection
: UV at 210 nm, 0.26 AUFS
Injection
: 15 μL (2.5 mg/mL)
Column
: YMC-Pack Pro C18 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/10mM oxalic acid (10/90)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 280 nm, 0.13 AUFS
Injection
: 6 μL (0.2 mg/mL)
ペニシリン系抗生物質
Penicillin antibiotics
アモキシシリン
Amoxicillin
テトラサイクリン系抗生物質
Tetracycline antibiotics
バンコマイシン
Vancomycin
1
1
Amoxicillin hydrate
2
Oxytetracycline hydrochloride
10
10
2
Ampicillin anhydrous
抗
菌
剤
・
抗
生
物
質
Tetracycline hydrochloride
(O950920C)
(S000728B)
(S000622D)
: J'sphere ODS-H80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: 50mM NaH2PO4 - H3PO4 (pH 2.3)/acetonitrile (80/20)
containing 20mM sodium 1-heptanesulfonate
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 220 nm, 0.13 AUFS
Injection
: 2 μL (0.3, 0.7 mg/mL)
(S970526B)
Column
100
Column
Column
: Hydrosphere C18 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile / water / TFA (10/90/0.1)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 220 nm, 0.32 AUFS
Injection
: 10 μL (0.2, 0.1 mg/mL)
Column
: J'sphere ODS-H80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/10mM oxalic acid (10/90)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 280 nm, 0.13 AUFS
Injection
: 4 μL (0.2 mg/mL)
: Hydrosphere C18 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 20mM KH2 PO4 - K2HPO4 (pH 6.9) / acetonitrile
(88/12)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 220 nm, 0.32 AUFS
Injection
: 10 μL (0.1 mg/mL)
101
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農薬、環境関連物質
農薬、環境関連物質
11 Pesticides, Environmental
11 Pesticides, Environmental
ベンスリド
O,O -Di-isopropyl S-2-benzenesulphonamidoethylphosphorodithioate
チウラム
Bis(dimethylthiocarbamoyl)disulfide
除草剤
Herbicides
アトラジン誘導体
Atrazine derivatives
1. Atrazine-desisopropyl
2. Atrazine-desethyl
3. Crimidine
4. Hexazinone
5. Metoxuron
6. Simazine
7. Cyanazine
8. Atraton
9. Atrazine
10. Isoproturon
11. Diuron
12. Prometon
13. Metobromuron
14. Terbumeton
15. Metazachlor
16. Ametryn
17. Sebuthylazine
18. Propazine
19. Terbuthylazine
20. Linuron
21. Prometryn
22. Terbutryn
23. Metolachlor
1.Thiram
1.Bensulide
1
Atrazine-2-hydroxy
2
Atrazine-desisopropyl
3
Atrazine-desethyl
4
Atrazine
(O941018B)
Column
: YMC-Pack MB-ODS
150 × 2.1 mm I.D.
Eluent
: acetonitrile/water (60/40)
Flow rate
: 0.3 mL/min
Temperature : 30 ℃
Detection
: UV at 220 nm, 0.01 AUFS
Injection
: 10μL (1.0 mg/L)
Column
: YMC-Pack MB-ODS
150 × 2.1 mm I.D.
Eluent
: acetonitrile/water (40/60)
Flow rate
: 0.3 mL/min
Temperature : 30 ℃
Detection
: UV at 260 nm, 0.01 AUFS
Injection
: 10 μL (2.0 mg/L)
: J'sphere ODS-H80 (4μm, 8nm)
250 × 4.6 mm I.D.
Eluent
: A)acetonitrile/50mM NH4 H2 PO4 (20/80)
B)acetonitrile/50mM NH4H2PO4 (65/35)
0-100%B (0-60min, linear)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 230 nm, 0.16 AUFS
Injection
: 5 μL (0.04 mg/mL)
アシュラム
Methyl sulfanilylcarbamate
オキシン銅
Copper 8-quinolinolate
トリアジン系除草剤
Triazine herbicides
(G910223E)
(G910223D)
1.Asulam
Column
(O941020H)
Column
: J'sphere ODS-H80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: acetonitrile/water/TFA (25/75/0.1)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 230 nm, 0.16 AUFS
Injection
: 5 μL (0.04 mg/mL)
トリアジン系除草剤
Triazine herbicides
1. Copper 8-quinolinolate
5
1
1. Cyanazine
2. Simazine
3. Atraton
4. Atrazine
5. Prometon
6. Terbumeton
7. Sebuthylazine
8. Propazine
9. Terbuthylazine
10. Prometryn
11. Terbutryn
Simazine
Sebuthylazine
6
2
Atrazine
11
Propazine
7
3
Prometon
農
薬
・
環
境
関
連
物
質
Terbuthylazine
8
4
Terbumeton
Prometryn
9
Terbutryn
(G910223C)
Column
: YMC-Pack MB-ODS
150 × 2.1 mm I.D.
Eluent
: THF/water/TFA (10/90/0.05)
Flow rate
: 0.3 mL/min
Temperature : 30 ℃
Detection
: UV at 260 nm, 0.01 AUFS
Injection
: 10 μL (1.0 mg/L)
102
(A010717A)
Column
: Hydrosphere C18 (5μm, 12nm)
150 × 2.0 mm I.D.
Eluent
: acetonitrile/20mM H3PO4 (5/95)
Flow rate
: 0.2 mL/min
Temperature : 37 ℃
Detection
: UV at 250 nm, 0.32 AUFS
Injection
: 2 μL (0.02 mg/mL)
(O941102F)
Column
: J'sphere ODS-H80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/50mM NH 4H2PO4 (45/55)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 230 nm, 0.32 AUFS
Injection
: 5 μL (0.05 mg/mL)
(A970210B)
Column
: YMC-Pack Pro C18 (5μm, 12nm)
250 × 4.6 mm I.D.
Eluent
: acetonitrile/50mM NH4H2PO4 (45/55)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 230 nm, 0.32 AUFS
Injection
: 5 μL (0.05 mg/mL)
103
11
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農薬、環境関連物質
農薬、環境関連物質
11 Pesticides, Environmental
11 Pesticides, Environmental
尿素系除草剤
Urea herbicides
酸アミド系除草剤
Acid amide herbicides
1
防かび剤
Fungicides
防かび剤
Fungicides
1
1
1
Metoxuron
Metazachlor
2
Thiabendazole
Thiabendazole
2
2
2
Isoproturon
3
o-Phenylphenol
o-Phenylphenol
Metolachlor
3
3
3
Diuron
4
Alachlor
Metobromuron
Imazalil
Imazalil
4
4
4
5
Diphenyl
Diphenyl
Butachlor
Linuron
(O941028B)
(O941108C)
(A970217A)
(A970219A)
Column
: J'sphere ODS-H80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: THF/water (30/70)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.16 AUFS
Injection
: 4 μL (0.2 mg/mL)
Column
: J'sphere ODS-M80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: 2-propanol/THF/water (25/15/60)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 210 nm, 0.16 AUFS
Injection
: 8 μL (0.05 mg/mL)
Column
: YMC-Pack Pro C18 (5 μm, 12nm)
75 × 4.6 mm I.D.
Eluent
: methanol/20mM NH4 H2 PO4 (70/30)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 230 nm, 0.32 AUFS
Injection
: 10 μL (0.02∼0.20 mg/mL)
: YMC-Pack ODS-A (5μm, 12nm)
75 × 4.6 mm I.D.
Eluent
: methanol/20mM NH4H2PO4 (70/30)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 230 nm, 0.32 AUFS
Injection
: 10 μL (0.02 ∼0.20 mg/mL)
カルバメート系除草剤
Carbamate herbicides
カルバメート系殺虫剤
Carbamate insecticides
イマザリル
Imazalil
アルデヒドおよびケトン類の 2,4-DNPH誘導体
2,4-Dinitrophenylhydrazones of aldehydes and ketones
Column
1.Formaldehyde 2,4-DNPH
2.Acetaldehyde 2,4-DNPH
3.Acetone 2,4-DNPH
4.Acrolein 2,4-DNPH
5.Propionaldehyde 2,4-DNPH
6.Crotonaldehyde 2,4-DNPH
7.Methylethylketone 2,4-DNPH
8.Isobutyraldehyde 2,4-DNPH
9.Benzaldehyde 2,4-DNPH
10.n-Valeraldehyde 2,4-DNPH
11.p-Tolualdehyde 2,4-DNPH
12.Capronaldehyde 2,4-DNPH
1.Imazalil
1
Propham
2
Swep
11
11
3
Chloropropham
農
薬
・
環
境
関
連
物
質
(T920302A)
Column
(O941124G)
Column
: J'sphere ODS-L80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: acetonitrile/water (45/55)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 240 nm, 0.16 AUFS
Injection
: 5 μL (0.08 mg/mL)
104
(J010220D)
Column
: Hydrosphere C18 (3μm, 12nm)
75 × 4.6 mm I.D.
Eluent
: methanol / 20mM KH2PO4 (45/55)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 240 nm, 0.64 AUFS
Injection
: 5 μL (0.1 - 1.5 mg/mL)
(B931007A)
Column
: J'sphere ODS-M80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/20mM NH4H2PO4 (50/50)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 230 nm, 0.04 AUFS
Injection
: 10 μL (0.05 mg/mL)
: YMC-Pack C4 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: A)tetrahydrofuran/water (10/90)
B)acetonitrile
35%B (0-7min), 35-65%B (7-18min, linear), 100%B (18-19min),
35%B (19-35min)
Flow rate
: 1.5 mL/min
Temperature : 30 ℃
Detection
: UV at 360 nm, 0.01 AUFS
Injection
: 11 μL (0.0025 mg/mL)
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農薬、環境関連物質
その他
11 Pesticides, Environmental
12 The others
アルデヒドおよびケトン類の2,4-DNPH誘導体
2,4-dinitrophenylhydrazones of aldehydes and ketones
多環芳香族炭化水素
Polyaromatic hydrocarbons
ヒドロキシ安息香酸
Hydroxybenzoic acids
1.Benzene
2.Naphthalene
3.7,12-Dimethylbenzo[a]anthracene
4.Acenaphthylene
5.Diphenyl
6.Fluorene
7.Naphthacene
8.Acenaphthene
9.Phenanthrene
10.Anthrathene
11.Fluoranthene
12.Pyrene
13.Triphenylene
14.Chrysene
15.Perylene
16.Benzo[e]pyrene
17.Benzo[b]fluoranthene
18.Benzo[k]fluoranthene
19.Benzo[a]pyrene
20.Dibenzo[a,h]anthracene
21.Benzo[g,h,i]perylene
22.Coronene
1.Formaldehyde 2,4-DNPH
2.Acetaldehyde 2,4-DNPH
3.Acetone 2,4-DNPH
4.Acrolein 2,4-DNPH
5.Propionaldehyde 2,4-DNPH
6.Crotonaldehyde 2,4-DNPH
7.Methylethylketone 2,4-DNPH
8.Isobutyraldehyde 2,4-DNPH
9.Benzaldehyde 2,4-DNPH
10.n-Valeraldehyde 2,4-DNPH
11.p-Tolualdehyde 2,4-DNPH
12.Capronaldehyde 2,4-DNPH
レゾルシン酸異性体
Resorcylic acid isomers
4
1
7
1
3,5-DHBA
2,5-DHBA
5
2
2,3-DHBA
8
α-Resorcylic acid
2
3,4-DHBA
2,4-DHBA
6
3
Benzoic acid
9
β-Resorcylic acid
3
p-HBA
m-HBA
Salicylic acid
Resorcinol
DHBA, Dihydroxybenzoic acid
HBA, Hydroxybenzoic acid
4
γ-Resorcylic acid
(T931130D)
Column
: J'sphere ODS-H80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: A)tetrahydrofuran/water (20/80)
B)acetonitrile/methanol (90/10)
30-67%B (0-15min, Linear), 30%B (15-25min)
Flow rate
: 1.0 mL/min
Temperature : 40 ℃
Detection
: UV at 360 nm, 0.01 AUFS
Injection
: 15 μL (0.001 mg/mL)
Column
: J'sphere ODS-H80 (4μm, 8nm)
250 × 4.6 mm I.D.
Eluent
: acetonitrile/water (65/35)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.08 AUFS
Injection
: 7 μL
Column
: J'sphere ODS-H80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/water/acetic acid (5/90/5)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 285 nm, 0.16 AUFS
Injection
: 5 μL (0.1 mg/mL)
Column
多環芳香族炭化水素
Polyaromatic hydrocarbons
多環芳香族炭化水素
Polyaromatic hydrocarbons
レゾルシン酸異性体
Resorcylic acid isomers
安息香酸誘導体
Benzoic acid derivatives
(K930918A)
1.Benzene
2.Naphthalene
3.Acenaphthylene
4.7,12-Dimethylbenzo[a]anthracene
5.Diphenyl
6.Fluorene
7.Acenaphthene
8.Naphthacene
9.Phenanthrene
10.Anthrathene
11.Fluoranthene
12.Pyrene
13.Triphenylene
14.Chrysene
15.Perylene
16.Benzo[e]pyrene
17.Benzo[b]fluoranthene
18.Benzo[k]fluoranthene
19.Benzo[a]pyrene
20.Dibenzo[a,h]anthracene
21.Benzo[g,h,i]perylene
22.Coronene
11
農
薬
・
環
境
関
連
物
質
(O940530D)
1.Benzene
2.Naphthalene
3.7,12-Dimethylbenzo[a]anthracene
4.Acenaphthylene
5.Diphenyl
6.Fluorene
7.Naphthacene
8.Acenaphthene
9.Phenanthrene
10.Anthrathene
11.Fluoranthene
12.Pyrene
13.Triphenylene
14.Chrysene
15.Perylene
16.Benzo[e]pyrene
17.Benzo[b]fluoranthene
18.Benzo[k]fluoranthene
19.Benzo[a]pyrene
20.Dibenzo[a,h]anthracene
21.Benzo[g,h,i]perylene
22.Coronene
(O940607C)
: YMC-Pack C8 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: methanol/100mM KH2PO4 (10/90)
Flow rate
: 0.8 mL/min
Temperature : 37 ℃
Detection
: UV at 285 nm, 0.16 AUFS
Injection
: 10 μL (0.05 ∼0.4 mg/mL)
1
1
p-Ethoxybenzoic acid
2
α-Resorcylic acid
2
p-Propoxybenzoic acid
3
β-Resorcylic acid
3
4
Resorcinol
p-Isopropylbenzoic acid
(Cuminic acid)
4
p-Buthoxybenzoic acid
12
5
γ-Resorcylic acid
p-tert-Butylbenzoic acid
(K930918C)
(K930918B)
Column
: J'sphere ODS-M80 (4μm, 8nm)
250 × 4.6 mm I.D.
Eluent
: acetonitrile/water (65/35)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.08 AUFS
Injection
: 7 μL
106
Column
: J'sphere ODS-H80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: A)acetonitrile/water (50/50)
B)acetonitrile
30%B (0-5min), 30-100%B (5-40min), 100%B (40-50min)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.08 AUFS
Injection
: 7 μL
(O940606J)
Column
: YMC-Pack Ph (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: methanol/100mM KH2PO4 (10/90)
Flow rate
: 0.8 mL/min
Temperature : 37 ℃
Detection
: UV at 285 nm, 0.16 AUFS
Injection
: 10 μL (0.05∼0.4 mg/mL)
(O950511B)
Column
: J'sphere ODS-M80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: tetrahydrofuran/water/acetic acid (40/60/1)
Flow rate
: 0.5 mL/min
Temperature : ambient (26 ℃)
Detection
: UV at 260 nm, 0.32 AUFS
Injection
: 10 μL (0.04 ∼0.2 mg/mL)
107
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その他
その他
12 The others
12 The others
安息香酸誘導体
Benzoic acid derivatives
メトキシ安息香酸異性体
Methoxybenzoic acid isomers
クロロ安息香酸異性体
Chlorobenzoic acid isomers
ポリフェノール
Polyphenols
1
1
p-Ethoxybenzoic acid
o-Chlorobenzoic acid
2
o-Methoxybenzoic acid
(o-Anisic acid)
2
1
3
2
p-Propoxybenzoic acid
3
m-Chlorobenzoic acid
p-Isopropylbenzoic acid
(Cuminic acid)
4
3
p-Methoxybenzoic acid
(p-Anisic acid)
4
1.Pyrogallol
2.Hydroquinone
3.Catechol
4.Phenol
2
1
3
p-Chlorobenzoic acid
m-Methoxybenzoic acid
(m-Anisic acid)
p-Buthoxybenzoic acid
5
0
p-tert-Butylbenzoic acid
10
20min
(H890627A)
(O950511C)
(O950508A)
(O950509D)
Column
: J'sphere ODS-L80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: tetrahydrofuran/water/acetic acid (40/60/1)
Flow rate
: 0.5 mL/min
Temperature : ambient (26 ℃)
Detection
: UV at 260 nm, 0.32 AUFS
Injection
: 10 μL (0.04∼0.2 mg/mL)
Column
: J'sphere ODS-H80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: acetonitrile/water/acetic acid (20/80/1)
Flow rate
: 1.0 mL/min
Temperature : ambient (25 ℃)
Detection
: UV at 285 nm, 0.16 AUFS
Injection
: 10 μL (0.17 mg/mL)
: YMC-Pack ODS-AM (5 μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/water/acetic acid (25/75/1)
Flow rate
: 1.0 mL/min
Temperature : ambient (27 ℃)
Detection
: UV at 270 nm, 0.04 AUFS
Injection
: 10 μL (0.17 mg/mL)
Column
: YMC-Pack Ph (5μm, 12nm)
250 × 4.6 mm I.D.
Eluent
: 5mM acetic acid
Flow rate
: 1.0 mL/min
Temperature : 25 ℃
Detection
: UV at 280 nm, 0.32 AUFS
Sample
: reagents
Injection
: 20 μL
メトキシ安息香酸異性体
Methoxybenzoic acid isomers
クロロ安息香酸異性体
Chlorobenzoic acid isomers
ジメチルフェノール異性体
Dimethylphenol isomers
ジメチルフェノール異性体
Dimethylphenol isomers
Column
1
1
2
1
2
2,6-Dimethylphenol
2,5-Dimethylphenol
4
1
2,6-Dimethylphenol
o-Chlorobenzoic acid
o-Methoxybenzoic acid
(o-Anisic acid)
3
2,5-Dimethylphenol
4
3
2
2,4-Dimethylphenol
2
5
2,4-Dimethylphenol
2,3-Dimethylphenol
5
6
2,3-Dimethylphenol
6
m-Chlorobenzoic acid
3
p-Methoxybenzoic acid
(p-Anisic acid)
3,5-Dimethylphenol
3,4-Dimethylphenol
3,5-Dimethylphenol
3,4-Dimethylphenol
3
p-Chlorobenzoic acid
m-Methoxybenzoic acid
(m-Anisic acid)
12
12
そ
の
他
(O950508B)
Column
: J'sphere ODS-M80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: acetonitrile/water/acetic acid (20/80/1)
Flow rate
: 1.0 mL/min
Temperature : ambient (25 ℃)
Detection
: UV at 285 nm, 0.16 AUFS
Injection
: 10 μL (0.17 mg/mL)
108
(O950509B)
Column
: J'sphere ODS-H80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/water/acetic acid (25/75/1)
Flow rate
: 1.0 mL/min
Temperature : ambient (27 ℃)
Detection
: UV at 270 nm, 0.04 AUFS
Injection
: 10 μL (0.17 mg/mL)
(T921019B)
: YMC-Pack Polyamine Ⅱ
250 × 4.6 mm I.D.
Eluent
: 20% ethyl acetate in hexane
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 254 nm, 0.08 AUFS
Injection
: 20 μL (0.33 mg/mL)
Column
(T921020C)
Column
: YMC-Pack NH2 (5μm, 12nm)
250 × 4.6 mm I.D.
Eluent
: 10% ethyl acetate in hexane
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 254 nm, 0.08 AUFS
Injection
: 20 μL (0.33 mg/mL)
109
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その他
その他
12 The others
フェノール誘導体
Phenol derivatives
12 The others
フェノール誘導体
Phenol derivatives
1
クレゾール異性体
Cresol isomers
1
o-Nitrophenol
1- (2-ピリジルアゾ) -2-ナフトール(PAN)金属キレート
Metal-PAN chelates
1.Co (Ⅱ)-1- (2-Pyridylazo)-2-naphthol
2.Ni (Ⅱ)-1- (2-Pyridylazo)-2-naphthol
3.Fe (Ⅲ)-1- (2-Pyridylazo)-2-naphthol
4.Zn (Ⅱ)-1- (2-Pyridylazo)-2-naphthol
1
2,6-Dinitrophenol
2
2
m-Cresol
o-Chlorophenol
2,4,6-Trinitrophenol
3
2,4-Dinitrophenol
4
3
2
m-Nitrophenol
4
p-Cresol
3
p-Nitrophenol
2,6-Dichlorophenol
5
5
o-Cresol
m-Chlorophenol
2,4-Dichlorophenol
6
6
p-Chlorophenol
2,4,6-Trichlorophenol
(T910520A)
(O950616I)
(O950614C)
(O951025C)
Column
Column
: J'sphere ODS-H80 (4μm, 8nm)
75 × 4.6 mm I.D.
Eluent
: 2-propanol/water/TFA (40/60/0.1)
Flow rate
: 0.4 mL/min
Temperature : 37 ℃
Detection
: UV at 230 nm, 0.13 AUFS
Injection
: 5 μL (0.04 mg/mL)
フェノール誘導体
Phenol derivatives
1
Column
: J'sphere ODS-H80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: tetrahydrofuran/water/acetic acid (35/65/1)
Flow rate
: 0.5 mL/min
Temperature : 37 ℃
Detection
: UV at 240 nm, 0.13 AUFS
Injection
: 4 μL (0.08 mg/mL)
: J'sphere ODS-M80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/water (18/82)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.064 AUFS
Injection
: 10 μL (0.3 mg/mL)
: YMC-Pack ODS-AM (5μm, 12nm)
150 × 6.0 mm I.D.
Eluent
: acetonitrile/water (70/30) containig 0.01% PAN
and 10mM tetrabutylammonium bromide
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: VIS at 565 nm, 0.08 AUFS
Injection
: 12 μL (25∼92 μg/mL)
クレゾール異性体
Cresol isomers
配位性化合物
Coordination compounds
ヒノキチオール
Hinokitiol
o-Nitrophenol
Column
1. Uracil
2. Acetylacetone
3. 8-Quinolinol
1
2
1
m-Cresol
o-Chlorophenol
3
2
Hinokitiol
2
m-Nitrophenol
p-Cresol
4
3
1-Naphthol(I.S.)
p-Nitrophenol
5
12
o-Cresol
12
m-Chlorophenol
6
そ
の
他
p-Chlorophenol
(O950614F)
Column
: YMC-Pack ODS-AM (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: tetrahydrofuran/water/acetic acid (35/65/1)
Flow rate
: 0.5 mL/min
Temperature : 37 ℃
Detection
: UV at 240 nm, 0.13 AUFS
Injection
: 4 μL (0.08 mg/mL)
110
(O951025B)
Column
: J'sphere ODS-H80 (4μm, 8nm)
150 × 4.6 mm I.D.
Eluent
: acetonitrile/water (18/82)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 260 nm, 0.064 AUFS
Injection
: 10 μL (0.3 mg/mL)
(M910604I)
Column
: YMC-Pack ODS-AM (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 20mM KH2PO4 - K2HPO4 (pH7.6)/methanol (40/60)
Flow rate
: 1.0 mL/min
Temperature : 40 ℃
Detection
: UV at 254 nm, 0.32 AUFS
(O960507F)
Column
: YMC-Pack ODS-AM (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 20mM NH4H2PO 4 containing 1mM EDTA･2Na/acetonitrile (65/35)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 320 nm, 0.16 AUFS
Injection
: 10 μL (0.08, 0.25 mg/mL)
111
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その他
その他
12 The others
12 The others
アミノアルコール
Aminoalcohols
尿素及び関連化合物
Urea and related compounds
1.Ethanolamine
2.Diethanolamine
3.N-Methylethanolamine
4.Triethanolamine
5.N,N-Dimethylethanolamine
フラーレン同族体
Fullerenes
1.Urea
2.Propionamide
3.Ethylurea
4.1,3-Diethylurea
5.1,1-Diethylurea
フラーレン同族体
Fullerenes
1
1
Buckminsterfullerene(C60)
Buckminsterfullerene(C60)
2
2
(5,6)-Fullerene(C70)
(5,6)-Fullerene(C70)
(M920124B)
(M920108A)
(S930119B)
Column
: YMC-Pack PolymerC18
250 × 6.0 mm I.D.
Eluent
: 100mM Na 2HPO4/100mM NaOH (60/40, pH 12.0)
Flow rate
: 0.6 mL/min
Temperature : 20 ℃
Detection
: UV at 215 nm, 0.32 AUFS
Injection
: 50 μL (0.2∼3.0 mg/mL)
Column
: YMC-Pack PolymerC18
250 × 6.0 mm I.D.
Eluent
: 0.4% HClO4 (pH 1.3)
Flow rate
: 0.5 mL/min
Temperature : 25 ℃
Detection
: UV at 210 nm, 0.32 AUFS
Injection
: 15 μL (0.4 ∼7.5 mg/mL)
Column
界面活性剤
A nonionic detergent
ポリエチレングリコール
Polyethyleneglycols
芳香族アミン
Aromatic amines
1.Triton X-100
: YMC-Pack ODS-A (5μm, 120A)
150 × 6.0 mm I.D.
Eluent
: hexane/2-propanol (70/30)
Flow rate
: 1.0 mL/min
Temperature : ambient (25 ℃)
Detection
: UV at 350 nm, 0.08 AUFS
Injection
: 4 μL (0.125 mg/mL)
1.PEG #20,000
2.PEG #6,000
3.PEG #4,000
4.PEG #1,000
5.PEG
#300
6.Ethyleneglycol
(MW 20,000)
(MW 8,400)
(MW 3,350)
(MW 1,000)
(MW
300)
(MW
62)
(S930128B)
Column
: YMC-Pack Ph (5μm, 120A)
150 × 6.0 mm I.D.
Eluent
: hexane/2-propanol (50/50)
Flow rate
: 1.0 mL/min
Temperature : ambient (25 ℃)
Detection
: UV at 350 nm, 0.08 AUFS
Injection
: 4 μL (0.125 mg/mL)
芳香族アミン
Aromatic amines
1
1
p-Phenylenediamine
p-Phenylenediamine
2
2
p-Aminophenol
p-Aminophenol
3
3
m-Phenylenediamine
m-Phenylenediamine
4
4
m-Aminophenol
m-Aminophenol
5
5
12
o-Phenylenediamine
o-Phenylenediamine
6
6
そ
の
他
o-Aminophenol
o-Aminophenol
(G920109C)
(G920123A)
: YMC-Pack Diol-120
500 × 8.0 mm I.D.
Eluent
: acetonitrile/water (10/90)
Flow rate
: 1.0 mL/min
Temperature : ambient (23 ℃)
Detection
: UV at 260 nm, 0.02 AUFS
Injection
: 15 μL (5.0 mg/mL)
Sample
: Triton X-100
(S961007C)
(S961004E)
Column
112
Column
: YMC-Pack Diol-120
500 × 8.0 mm I.D.
Eluent
: acetonitrile/water(10/90)
Flow rate
: 1.0 mL/min
Temperature : ambient (22 ℃)
Detection
: RI, 64 x 10-6 RIU/FS
Injection
: 100 μL (1.67 mg/mL)
Column
: YMC-Pack Pro C18 (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 50mM NH4H2PO4 - (NH4 )2HPO 4 (pH 6.7)/methanol (95/5)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.26 AUFS
Injection
: 5 μL (0.125∼0.5 mg/mL)
Column
: YMC-Pack ODS-AM (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: 50mM NH4 H2 PO4 - (NH4)2 HPO4 (pH 6.7)/methanol (95/5)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.26 AUFS
Injection
: 5 μL (0.125∼0.5 mg/mL)
113
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その他
光学異性体
12 The others
13 Optical isomers
フタル酸異性体
Phthalic acid isomers
フタル酸異性体
Phthalic acid isomers
ビナフトール
1,1'-Bi-2-naphthol
トリフルオロアンスリルエタノール
2,2,2-Trifluoro-1-(9-anthryl)-ethanol
Column
: YMC CHIRAL NEA (R)
250 × 4.6 mm I.D.
Eluent
: acetonitrile/water (50/50)
Flow rate
: 1.0 mL/min
Temperature : ambient
Detection
: UV at 235 nm
Injection
: 1 μL (2.8 mg/mL)
Column
: YMC CHIRAL NEA (R)
250 × 4.6 mm I.D.
Eluent
: acetonitrile/water (40/60)
Flow rate
: 1.0 mL/min
Temperature : ambient
Detection
: UV at 254 nm
Injection
: 1 μL (0.14 mg/mL)
ヘキソバルビタール
Hexobarbital
CBZ-フェニルアラニン
CBZ-Phenylalanine(Z-Phe-OH)
1
1
Phthalic acid
Phthalic acid
2
2
Terephthalic acid
Terephthalic acid
3
3
Isophthalic acid
Isophthalic acid
(A971112B)
Column
: YMC-Pack Pro C18 (5μm, 12nm)
150 × 3.0 mm I.D.
Eluent
: methanol/10mM H 3PO4 (25/75)
Flow rate
: 0.4 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.16 AUFS
Injection
: 4 μL (0.05∼0.5 mg/mL)
(A971112A)
Column
: YMC-Pack ODS-AQ (5μm, 12nm)
150 × 4.6 mm I.D.
Eluent
: methanol/10mM H 3PO4 (25/75)
Flow rate
: 1.0 mL/min
Temperature : 37 ℃
Detection
: UV at 254 nm, 0.16 AUFS
Injection
: 10 μL (0.05∼0.5 mg/mL)
12
そ
の
他
13
Column
: YMC CHIRAL NEA (R)
250 × 4.6 mm I.D.
Eluent
: acetonitrile/water (30/70)
Flow rate
: 0.7 mL/min
Temperature : ambient
Detection
: UV at 210 nm
Injection
: 1 μL (1.2 mg/mL)
114
Column
: YMC CHIRAL NEA (R)
250 × 4.6 mm I.D.
Eluent
: 0.5M NaClO4 - HClO4 (pH 2.0)/acetonitrile (70/30)
Flow rate
: 1.0 mL/min
Temperature : ambient
Detection
: UV at 254 nm
Injection
: 10 μL (1.5 mg/mL)
115
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光学異性体
光学異性体
13 Optical isomers
13 Optical isomers
塩酸プロプラノロール
Propranolol hydrochloride
塩酸ケタミン
Ketamine hydrochloride
フルルビプロフェン
Flurbiprofen
ヘキソバルビタール
Hexobarbital
Column
: YMC CHIRAL NEA (R)
250 × 4.6 mm I.D.
Eluent
: acetonitrile/0.5M NaClO 4 (40/60)
Flow rate
: 1.0 mL/min
Temperature : ambient
Detection
: UV at 254 nm
Injection
: 5 μL (1.5 mg/mL)
Column
Column
: YMC CHIRAL NEA (R)
250 × 4.6 mm I.D.
Eluent
: acetonitrile/0.5M NaClO4 (40/60)
Flow rate
: 1.0 mL/min
Temperature : ambient
Detection
: UV at 268 nm
Injection
: 10 μL (1.4 mg/mL)
: YMC CHIRAL β-CD BR
250 × 4.6 mm I.D.
Eluent
: 0.53M AcOH - 0.53M TEA (pH 4.0)/acetonitrile (10/90)
(TEA=triethylamine)
Flow rate
: 1.0 mL/min
Temperature : 25 ℃
Detection
: UV at 254 nm
Injection
: 2 μL (1 mg/mL)
: YMC CHIRAL β-CD BR
250 × 4.6 mm I.D.
Eluent
: 0.2M AcOH - 0.2M TEA (pH 5.6)/methanol (70/30)
(TEA=triethylamine)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 254 nm
Injection
: 5 μL (1 mg/mL)
クロルタリドン
Chlorthalidone
フェノプロフェンカルシウム
Fenoprofen calcium salt; hydrate
イブプロフェン
Ibuprofen
インダパミド
Indapamide
Column
13
光
学
異
性
体
13
: YMC CHIRAL β-CD BR
250 × 4.6 mm I.D.
Eluent
: 0.53M AcOH - 0.53M TEA (pH 4.0)/acetonitrile (10/90)
(TEA=triethylamine)
Flow rate
: 1.0 mL/min
Temperature : 25 ℃
Detection
: UV at 254 nm
Injection
: 5 μL (1 mg/mL)
Column
: YMC CHIRAL β-CD BR
250 × 4.6 mm I.D.
Eluent
: water/acetic acid (100/1)
Flow rate
: 1.0 mL/min
Temperature : 25 ℃
Detection
: UV at 254 nm
Injection
: 2 μL (1 mg/mL)
Column
116
: YMC CHIRAL β-CD BR
250 × 4.6 mm I.D.
Eluent
: 0.1M AcOHaq - TEAaq (pH 4.0)/acetonitrile (10/90)
(TEA=triethylamine)
Flow rate
: 1.0 mL/min
Temperature : 25 ℃
Detection
: UV at 254 nm
Injection
: 20 μL (2 mg/mL)
Column
: YMC CHIRAL β-CD BR
250 × 4.6 mm I.D.
Eluent
: 0.2M AcOH - 0.2M TEA (pH 5.6)/acetonitrile (90/10)
(TEA=triethylamine)
Flow rate
: 1.0 mL/min
Temperature : 25 ℃
Detection
: UV at 254 nm
Injection
: 2 μL (1 mg/mL)
Column
117
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光学異性体
光学異性体
13 Optical isomers
13 Optical isomers
ケトプロフェン
Ketoprofen
CBZ-フェニルアラニン
CBZ-Phenylalanine (Z-Phe-OH)
フェニルエチルアルコール
Phenylethylalcohol
塩酸プロプラノロール
Propranolol hydrochloride
Column
: YMC CHIRAL β-CD BR
250 × 4.6 mm I.D.
Eluent
: 0.2M AcOH - 0.2M TEA (pH 5.6)/methanol (30/70)
(TEA=triethylamine)
Flow rate
: 1.0 mL/min
Temperature : 25 ℃
Detection
: UV at 254 nm
Injection
: 10 μL (1 mg/mL)
Column
: YMC CHIRAL β-CD BR
250 × 4.6 mm I.D.
Eluent
: 0.53M AcOH - 0.53M TEA (pH 4.0)/acetonitrile (40/60)
(TEA=triethylamine)
Flow rate
: 1.0 mL/min
Temperature : 25 ℃
Detection
: UV at 254 nm
Injection
: 5 μL (1 mg/mL)
Column
: YMC CHIRAL γ-CD BR
250 × 4.6 mm I.D.
Eluent
: 0.53M AcOH - 0.53M TEA (pH 4.0)/methanol (90/10)
(TEA=triethylamine)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 254 nm
Injection
: 5 μL (10 mg/mL)
: YMC CHIRAL γ-CD BR
250 × 4.6 mm I.D.
Eluent
: acetonitrile/methanol/acetic acid/triethylamine (99/1/0.3/0.25)
Flow rate
: 1.0 mL/min
Temperature : 25 ℃
Detection
: UV at 254 nm
Injection
: 5 μL (1 mg/mL)
フルルビプロフェン
Flurbiprofen
ナフチルエチルアルコール
1-(1-Naphthyl)-ethylalcohol
トレーガー塩基
Troger's base
CBZ-フェニルアラニン
CBZ-Phenylalanine (Z-Phe-OH)
Column
13
光
学
異
性
体
13
: YMC CHIRAL γ-CD BR
250 × 4.6 mm I.D.
Eluent
: 0.53M AcOH - 0.53M TEA (pH 4.0)/methanol (30/70)
(TEA=triethylamine)
Flow rate
: 1.0 mL/min
Temperature : 25 ℃
Detection
: UV at 254 nm
Injection
: 2 μL (1 mg/mL)
Column
118
: YMC CHIRAL γ-CD BR
250 × 4.6 mm I.D.
Eluent
: 0.2M AcOH - 0.2M TEA (pH 5.6)/methanol (90/10)
(TEA=triethylamine)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 254 nm
Injection
: 5 μL (1 mg/mL)
Column
: YMC CHIRAL γ-CD BR
250 × 4.6 mm I.D.
Eluent
: 0.2M AcOH - 0.2M TEA (pH 5.6)/acetonitrile (90/10)
(TEA=triethylamine)
Flow rate
: 1.0 mL/min
Temperature : 30 ℃
Detection
: UV at 254 nm
Injection
: 5 μL (1 mg/mL)
Column
: YMC CHIRAL γ-CD BR
250 × 4.6 mm I.D.
Eluent
: 0.53M AcOH - 0.53M TEA (pH 4.0)/acetonitrile (60/40)
(TEA=triethylamine)
Flow rate
: 1.0 mL/min
Temperature : 25 ℃
Detection
: UV at 254 nm
Injection
: 5 μL (1 mg/mL)
Column
119
ｱﾌﾟﾘｹｰｼｮﾝﾃﾞｰﾀ集03 01.11.12 0:17 PM ページ 120
120