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Phosphodiesterase Enzyme Inhibitors Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2024

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Phosphodiesterase are a diverse family of enzymes (11 isoenzymes) that play a key role in regulating intracellular levels of secondary messengers - cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate. These enzymes identified to
PHOSPHODIESTERASE ENZYME
(PDE) INHIBITORS MARKET
Global Industry Insights, Trends, Outlook, and
Opportunity Analysis, 2016–2024
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REPORT DESCRIPTION
Phosphodiesterase are a diverse family of enzymes (11 isoenzymes) that play a key role in
regulating intracellular levels of secondary messengers - cyclic adenosine monophosphate
(cAMP) and cyclic guanosine monophosphate. These enzymes identified to be
pharmacologically active in the 1950s, hydrolyses cyclic nucleotides to treat various
diseases such as cardiovascular, respiratory and erectile dysfunction. Distinct distribution
of all the types of isoenzymes has provided possibilities for selective target therapies.
The global phosphodiesterase enzyme inhibitors market can be better analyzed by
classifying it into two classes as selective phosphodiesterase enzyme inhibitors and nonselective phosphodiesterase enzyme inhibitors. Theophylline and papaverineare the two
most commonly used non-selective phosphodiesterase enzyme inhibitors for treating a
range of diseases (bronchodilation, cardiac disorder, etc.). Advent of selective
phosphodiesterase enzyme inhibitors has made a great impact in the medical treatment
sector. Increasing understanding of the individual PDE isoforms has and will result in the
emergence of better therapeutic drugs. Viagra (Sildenafil) is the best example to
substantiate the success and impact of PDE inhibitors.
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REPORT DESCRIPTION
The global phosphodiesterase enzyme inhibitors market is therefore analyzed based on the
drug class and application as follows:
• Drug Class
• Selective PDE inhibitors
• PDE-1
• PDE-2
• PDE-3
• PDE-4
• PDE-5
• Others
• Non-selective PDE inhibitors
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Increasing product developments to further improvise the phosphodiesterase enzyme inhibitors market outlook
• The global phosphodiesterase enzyme inhibitors market has recently gained traction on account of the
blockbuster PDE 5 inhibitor brands, Viagra and Cialis. This has also encouraged pharmaceutical companies to
research on other PDE inhibitor class. In addition, research on extended use of approved PDE inhibitors is
anticipated to benefit the drug in long term and contribute to the increasing revenues of PDE inhibitors market.
• Researchers from the John Hopkin University reviewed the trials of PDE-5 inhibitors in pediatric patients with
pulmonary hypertension. The researchers concluded that PDE-5 inhibitors can be safely prescribed to infants,
neonates and children with primary and secondary pulmonary hypertension (2017).
• Besides, PDE-5 inhibitor sildenafil accidently developed for treating angina, was also found to be effective in
erectile dysfunction and now is observed to benefit heart attack patients. Researchers at Karolinska Institutet,
Sweden reported in March 2017 that PDE-5 inhibitors prescribed for erectile dysfunction can lower the risk of
death of hospitalization for heart failure in men who have had one heart attack in their lifetime.
• Pfizer, Inc. received FDA approval for its PDE-4 inhibitor Crisaborole (Eucris) in December 2016 for the treatment
of mild to moderate atopic dermatitis. Eucrisa the first non-steroidal topical monotherapy for skin disorder.
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Some of the key players operating in the global phosphodiesterase enzyme inhibitors market
include Pfizer, Inc., AstraZeneca plc, Bayer AG, Eli Lilly & Company, Celgene Corporation, Mist
Pharmaceuticals.
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