Bioreactors Market

Bioreactors Market - Global Industry Insights,
Trends, Outlook, and Opportunity Analysis, 20182026
Bioreactor is an engineered or manufactured vessel that is used in the production of wide range
of biological products. Industrial bioreactor is a vessel in which biochemical process is carried
out using microbes and animal cells or biologically active compounds that are derived from
living cells. Bioreactors are cylindrical in shape with capacity of liters to cubic meters and is
the most important component involved in bioprocessing. Fermentation processes such as wine,
and beer production are carried out in bioreactors. Bioreactors for large scale production of
therapeutic products are made of stainless steel. In biopharmaceutical companies, small glass
bioreactors are used for research and development purpose and for scale up activities. Another
type of bioreactors are disposable bioreactors, which are meant for single use and hence are
called as single-use bioreactors. It is generally used for extensive research and manufacturing.
Bioreactors can operate in batch, fed batch, and continuous stirred tank processes. Bioreactors
are used to produce therapeutics, which include monoclonal antibodies, vaccines, stem cells,
and gene modified cells.
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Market Drivers
The efficiency of single-use bioreactors has increased across pharmaceutical industries in terms
of production, quality control, and procurement. Single-use bioreactors offer advantages such as
consistency in production, increase in speed of manufacturing, reduced operational cost, and
reduction in manufacturing time of finished dosage form, which foster growth of bioreactors
market. In 2016, as per the National Centre for Biotechnology Information (NCBI), operational
cost per gram of monoclonal antibody production (mAb) for single-use bioreactor is around 22%
lower than conventional system, mainly due to less labor, utilities, maintenance, and waste. For
commercial scale of monoclonal antibody production (mAb), conventional fed-batch bioreactors
usually require 10000L – 25000L stainless steel tank to culture cells and produce yield of 2-6 g/
L. However, single-use bioreactors employ continuous cell culture supply in 500L - 2000L tank
and produces 10 - 30 times higher cell density. Therefore, more quantity of products can be
produced by using this single-use bioreactors, with less space and capital cost. Other factors
that contribute to growth of the market include low water usage by single-use systems, less
floor space requirement, and low risk of cross contamination in single-use system. Furthermore,
in 2016, a case study by Cambridge Healthtech Institute stated that by using single-use (SU)
bioreactors, there can be an annual savings of US$ 250,000 in water generation for injections
and US$ 60,000 in labor time required to set up and cleaning of stainless steel tank. These
factors are expected to drive growth of the bioreactors market over the forecast period.
Market Regional Insights
North America is expected to hold dominant position in bioreactors market due to presence of
major biopharmaceutical manufacturing companies. Biopharmaceutical companies such as Gilead
Science, Inc., Amgen, and Biogen, Inc. in the U.S. actively conducts research on novel therapies
for the treatment of various diseases. Research of therapies associated with oncology such as
monoclonal antibodies require usage of bioreactors on small as well as large scale for
production purposes. Furthermore, according to the National Centre for Biotechnology
Information (NCBI), in 2014, 65.6% of the clinical scale manufacturers and around 42% of the
commercial manufacturers used single-use bioreactors to improve their bioprocessing. Europe is
expected to witness significant growth rate in the bioreactors market due to increasing usage of
bioreactors in biopharmaceutical companies. According to the Organization for Economic Cooperation and Development (OECD), in 2015, around 1,700 biopharmaceutical companies, which
utilize bioreactors, are from Europe.
Report includes chapters which deeply display the following deliverable about industry :
• Bioreactors Market Research Objective and Assumption
• Bioreactors Market Purview - Report Description, Executive Summary, and Coherent
Opportunity Map (COM)
• Bioreactors Market Dynamics, Regulations, and Trends Analysis - Market Dynamics, Regulatory
Scenario, Industry Trend, Merger and Acquisitions, New system Launch/Approvals, Value Chain
Analysis, Porter’s Analysis, and PEST Analysis
• Global Bioreactors Market, By Regions
• Bioreactors Market Competition by Manufacturers including Production, Share, Revenue,
Average Price, Manufacturing Base Distribution, Sales Area and Product Type.
• Bioreactors Market Manufacturers Profiles/Analysis including Company Basic Information,
Manufacturing Base and Its Competitors.
• Bioreactors Market Manufacturing Cost Analysis including Key Raw Materials and Key
Suppliers of Raw Materials.
• Industrial Chain, Sourcing Strategy and Downstream Buyers including Upstream Raw Materials
Sourcing and Downstream Buyers
• Marketing Strategy Analysis, Distributors/Traders including Marketing Channel, Market
Positioning and Distributors/Traders List.
• Market Effect Factors Analysis including Technology Progress/Risk, Consumer Needs/Customer
Preference Change and Economic/Political Environmental Change.
• Bioreactors Market Forecast including Production, Consumption, Import and Export Forecast
by Type, Applications and Region.
• Research Findings and Conclusion
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Key players operating in bioreactors market include Thermo Fisher Scientific, Inc., Merck KGaA,
GE Healthcare, Pall Corporation, ZETA Holdings GmbH, Sartorius AG BBI, Solaris, Praj HiPurity
Systems Limited, BiOENGiNEERiNG, INC., Infors AG, and Appplikon Biotechnology, Inc.
Market Taxonomy
Bioreactors market is segmented on the basis of bioreactor type, usage, capacity, end user, and
geography.
By Bioreactor type• Stainless Steel Bioreactor
• Glass Bioreactor
• Single-Use Bioreactor
By Usage• Large scale production
• Pilot-scale production
• Full scale production
By Capacity• 5L – 20L
• 20L - 200L
• 200L – 1500L
• Above 1500L
By End Users• Biopharmaceutical companies
• Research Organization
• Others
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Bioreactor is an engineered or manufactured vessel that is used in the production of wide range of biological products.

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