Dietary Fat Supply to Failing Hearts Determines Dynamic
Lipid Signaling for Nuclear Receptor Activation and
Oxidation of Stored TriglycerideCLINICAL PERSPECTIVE
by Ryan Lahey, Xuerong Wang, Andrew N. Carley, and E. Douglas Lewandowski
Circulation
Volume 130(20):1790-1799
November 11, 2014
Copyright © American Heart Association, Inc. All rights reserved.
Contractile function of sham-operated (SHAM) and hypertrophic (TAC) isolated perfused hearts.
Ryan Lahey et al. Circulation. 2014;130:1790-1799
Copyright © American Heart Association, Inc. All rights reserved.
Incorporation rates of 13C-oleate and 13C-palmitate into triglyceride (TG).
Ryan Lahey et al. Circulation. 2014;130:1790-1799
Copyright © American Heart Association, Inc. All rights reserved.
Myocardial triglyceride (TG) turnover and content, acyl intermediates, and related protein levels
of enzymes for TG dynamics.
Ryan Lahey et al. Circulation. 2014;130:1790-1799
Copyright © American Heart Association, Inc. All rights reserved.
Expression of peroxisome proliferator–activated receptor-α (PPAR-α) target genes and
diglyceride acyltransferase 1 (DGAT1), adipose triglyceride lipase (ATGL), and PPAR-γ
coactivator-1α (PGC-1α) and PGC-1β genes in perfused sham-operated (SHAM) and
hypertrophied (TAC) heart tissue.
Ryan Lahey et al. Circulation. 2014;130:1790-1799
Copyright © American Heart Association, Inc. All rights reserved.
Expression of peroxisome proliferator-activated receptor-α (PPAR-α) target genes and
diglyceride acyltransferase 1 (DGAT1), adipose triglyceride lipase (ATGL), and PPAR-γ
coactivator-1α (PGC-1α) and PGC-1β genes in sham-operated (SHAM) and hypertrophied (TAC)
hearts perfused with a 1:1 mix of oleate and palmitate.
Ryan Lahey et al. Circulation. 2014;130:1790-1799
Copyright © American Heart Association, Inc. All rights reserved.
Tricarboxylic acid (TCA) cycle flux and substrate contribution to oxidative ATP production.
Ryan Lahey et al. Circulation. 2014;130:1790-1799
Copyright © American Heart Association, Inc. All rights reserved.
Summary scheme depicting the proposed rate dependence of peroxisome proliferator–activated
receptor-α (PPAR-α) activation and triglyceride (TG) oxidation on TG turnover.
Ryan Lahey et al. Circulation. 2014;130:1790-1799
Copyright © American Heart Association, Inc. All rights reserved.