From: Collagen XVIII Short Isoform Is Critical for Retinal Vascularization, and Overexpression of the Tsp-1 Domain Affects
Eye Growth and Cataract Formation
Invest. Ophthalmol. Vis. Sci.. 2013;54(12):7450-7462. doi:10.1167/iovs.13-13039
Figure Legend:
Immunofluorescence stainings of FVB/N control eye and Col18a1P1/P1 , Col18a1P2/P2 , and Col18a1−/− mouse eyes at
postnatal day 7 with the anti–all-18-antibody (recognizing all isoforms of collagen XVIII) showed distinct expression
patterns for the short and medium/long isoforms. (A) In the anterior part of the FVB/N control mouse eye collagen XVIII
is localized to the BM zones of the ciliary body and iris epithelia (red arrow and red arrowhead, respectively) and to the
lens capsule (green arrow). (B) In the Col18a1P1/P1 mice the collagen XVIII immunosignal can be seen in the epithelia of
the ciliary body and the iris (red arrow and red arrowhead, respectively). (C) The anti–all-18 staining pattern in the
P2/P2 mice is similar to that in the FVB/N control mice, that is, collagen XVIII positivity could be seen in the
Col18a1
Date
of download:
7/31/2017
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epithelia of the ciliary body and the iris (red arrow and red arrowhead, respectively), and in the lens capsule (green