CURRICULUM VITAE Name: Ashraf Tawfik Mohamed Soliman Date of preparation: May 2012 A. GENERAL INFORMATION Office address: Office telephone: Department of Pediatrics University of Alexandria Alexandria-Egypt Pediatric Endocrinology Section Hamad Medical Corporation P.O. Box 3050 Doha, Qatar (974) 4439 1526 Office fax: (974) 4443 9571 Home address: Home telephone: Cell phone: Beeper: AlMasilah Compound, Al Rayyan Road, Sunset Street , Villa 134 (974) 4486 5075 (974) 55983874 (974) 434 5368 Email: Citizenship: [email protected] Egyptian Birth date: October 2, 1956 Birth place: Alexandria, Egypt Social Security Number: Not Applicable Marital status: Married Spouse’s name: Rania Kamal ElAlaily Children’s name and ages: Nada 19 years Mohamed 18 years Amr 17 years 1 B. EDUCATIONAL BACKGROUND Degree Institution name, city and state Dates attended Year Awarded MBBCh School of Medicine University of Alexandria Alexandria, Egypt, 1973-1979 1979 Master Degree in Pediatrics School of Medicine, University of Alexandria, Alexandria, Egypt 1980-1983 1983 Doctoral degree (MD) in Pediatrics, University of Alexandria, College of Medicine, Alexandria, Egypt 1983-1988 1988 Ph.D. University of Glamorgan, School of 1995-1998 Applied Sciences, Wales, U.K. 1998 FRCP Royal College of Physician, Edinburgh 1999 C. PROFESSIONAL POSITIONS AND EMPLOYMENT Post-doctoral training including residency/fellowship Title Institution name, city and state Dates Intern University of Alexandria, General Hospital, Alexandria, Egypt 1980-1981 Resident, Pediatrics University of Alexandria Children's Hospital, Alexandria, Egypt 1981-1984 Research Fellow of Pediatric Endocrinology University of Virginia Health Sciences Center, School of Medicine Charlottesville, Virginia 1986-1987 Fellow in Diabetology, Royal East Sussex Hospital, International Diabetes Hastings, England. Federation 1988 Clinical Fellow of Pediatric Endocrinology 1988-1990 Jackson Memorial Hospital University of Miami, School of Medicine Miami, Florida 2 Academic positions (teaching and research) Title Institution name, city and state Dates Assistant Lecturer in Pediatrics University of Alexandria Children’s Hospital 1985-1988 University of Alexandria Children’s Hospital 1988-1993 University of Alexandria Children's Hospital. 1993-1998 University of Alexandria Children’s Hospital 1998-2003 Weil Cornell Medical College –Qatar June 2006thru Lecturer in Pediatrics Associate Professor of Pediatrics Professor of Pediatrics and Endocrinology Clinical Associate Professor of Pediatrics Hospital positions (attending physician, if applicable) Title Institution name, city and state Dates Consultant Pediatric Endocrinologist Hamad Medical Corporation Doha, Qatar 2003-present Employment (other than positions listed above) Title Institution name, city and state Dates Chief, Department of Pediatrics Aflaj General Hospital, Riyadh, M.O.H., Saudi Arabia 1991-1992 Chief, Pediatric Endocrinology Division Royal Hospital, Muscat, Oman 1992-1996 Head, Pediatric Endocrinology /Diabetes Unit University of Alexandria Children’s Hospital 1996-2003 Name of specialty Board Certificate # Date of Certification ECFMG & VQE Educational commission for foreign medical graduates- 1979 & 1980 FRCP Royal college of PhysiciansEdinburgh 1998-1999 3 E. PROFESSIONAL MEMBERSHIPS (medical and scientific societies) Member/officer Name of Organization Dates held Member The Egyptian Pediatric Association 1987-present Member The Egyptian Pediatric Endocrinology Association 1988-present Member The Arab Society of Nephrology and Renal Transplantation 1989-present Member Alexandria Society for Mentally Handicapped Children 1990-present Member The Egyptian Pediatric Cardiology Association 1993-present Member Endocrine Society (USA) 1995-present Fellow Royal College of Physicians – Edinburgh - UK 1999-present Secretary General MAGAM (Mediterranean and middle east group for Adolescent Medicine)- Ferrera-Italy 2000-present Member European Society of Pediatric Endocrinology 2009- present 4 F. HONORS AND AWARDS Name of award Date awarded The best Fellow in Pediatrics-University of Miami, School of Medicine 1989 The National Egyptian Award for the Best Medical Scientific Researcher 1996 Professor Mohammed Fakhry Award for the Best Group of Researchers in Pediatrics- Egyptian Academy of Science and Research 1996 Medal of Excellence in Medical Sciences from His Excellency the President of Egypt 1997 Professor Yehia El-Gamal Award for the Best Group of Researchers in Pediatrics. Egyptian Academy of Science and Research. 1998 Professor Samy Khalifa Award for the Best Group of Researchers in Pediatric Hematology- Egyptian Academy of Science and Research Best Teacher in Pediatrics Award , Hamad Medical Center, Qatar 1999 2007 5 Editor and Reviewer of Peerreviewed International Journals: Co-Editor of : Rivista Italiana Medicina Adolescenza, Fererra , Italy Indexed in EMBASE/Compendex/ Geobase/SCOPUS Honorary Editorial Board of Research and Reports in Tropical Medicine (Invited) Reviewer for the following Journals: Archives of Diseases in childhood (UK) Pediatrics (USA) Hormone Research in Pediatrics European Society of Pediatric Endocrinology ( Reviewer for abstracts in the field of growth and calcium homeostasis for the annual conference) British Journal of Nutrition Indian J of Pediatrics. Pediatric International. Italian Journal of Pediatrics. Journal of Pediatric Neuroradiology Digestive Diseases and Sciences. Journal of Pediatric Biochemistry Qatar Medical Journal. Journal of Emergency Medicine , Trauma and acute care ( JEMTAC) (Qatar) 6 I. CURRENT AND PAST INSTITUTIONAL RESPONSIBILITIES AND PERCENT EFFORT Teaching (list courses and your role) Teaching activities include teaching undergraduate and postgraduate students. Giving lectures in general pediatrics and pediatric Endocrinology, inpatient thru ward rounds, outpatient endocrinology clinics. Dates 1984-present Undergraduate Medical Students 1. 2. Didactic Lectures: ( twice monthly) General pediatrics and pediatric Endocrinology Clinical teaching : Inpatient : thru ward rounds, morning reports and case discussions. Outpatient : thru our Pediatric and Pediatric Endocrinology Clinics. Basic Structural teaching program objectives include development of: History taking skills Clinical examination skills. The ability to use Biochemical and Imaging investigations related to the disease. Interpretation and diagnostic skills based on the clinical assessment Presentation and discussion skills Setting up a small clinical research project 1. Medical Student Evaluations.Written exams: 2-h exam after the Pediatric round( 2-month) and final (MBBCh) exam (3-h) at the end of the year. Developed Multiple choice, problem solving and short essay type of questions. 2. Clinical exams: 2 short-cases for end of round exam and 3 short-cases for final exam 3. Oral exam: each student is examined orally on 2 sessions by 2 examiners. 7 2 .Postgraduate students Diploma in Pediatrics(1- year program) and Master (3-year program, two parts) in Pediatrics and Doctor in Medicine in Pediatrics (4-5 years). Didactic Lectures ( once weekly) General pediatrics and pediatric Endocrinology Clinical teaching : Inpatient : thru ward rounds, morning reports and case discussions Outpatient : thru our Pediatric and Pediatric Endocrinology Clinics. Postgraduate student evaluations a. Written: include 3 exam papers (3-h each) 2 in General Pediatrics and one in Neonatology b. Clinical : 3 short cases: with 20-minute discussion. One long case: to test his/her ability to write-up a detailed and professional history, clinical examination and interpretation with differential diagnosis. c. Oral. The postgraduate is examined on 3 occasions (3 professors/session) 2 in general Pediatrics and 1 in Neonatology. Doctor Degree (Pediatrics): As Professor ( lecturer , moderator and supervisor of research thesis) A structured advanced (clinical and research ) program (4-years) for those with masters of Pediatrics who need to pursue higher academic career. 8 Clinical Care Inpatient care in the Department of Pediatrics at Alexandria University Children’s Hospital and a twice weekly outpatient pediatric endocrinology/diabetology clinic. Dates 1988-2003 Inpatient care in the Department of Pediatrics and division of Pediactric Endocrinology and a twice weekly pediatric endocrinology and diabetology clinic. I developed a special clinic to study growth and endocrine complications in chronic hemolytic diseases ( more than 200 patients enrolled) 2003-present 9 Clinical Mentorship Narratives about clinical mentorship and career advice with outcome. (If applicable, list related publications, abstracts and presentations - copy and paste from CV.) Please provide the name(s) of the individuals you have mentored if you are the primary supervisor and describe the clinical position held or level of training 1. Medical Student : Clinical mentorship ; 2 undergraduate students (WCMC-Q) 2009-2010 2. Residents: Clinical mentorship for 3 Residents ( Dr. Zeina, Dr Ishan, Dr. Mohamed Sobhy )…. All of them passed successfully their Arab Board final exam 3. Fellows : A) Endocrine Fellows; Clinical , Research Mentorship and Career development for all the fellows trained in Ped. Endocrinology Fellowship Program ( Dr. Fawzia alkhalf, Dr. Noora AlHumaidy , Dr. Aml Sabt) (research topics and publications included) B) Cardiology Fellows: Research Mentorship and Career development For ( Dr Saad Said, Ayman Khellah, and Haytham S)) research topics and publications included C) Gastroenterology Fellows: Research Mentorship and Career development For ( Dr Khaled Abohezeima, and Wesam S) (research topics and publications included) D) Hematology/Oncology Fellows: Research Mentorship and Career development For ( Dr Rasha Ashour) (research topics and publications included) E) Pulmonology Fellows : Research Mentorship and Career development For ( Dr Ahmed Aboshaheen) (research topics and publications included) F) Neonatology Fellows: Research Mentorship and Career development For ( Dr Emad Shatlah) (research topics and publications included) 10 Research work Performed by the above mentioned doctors and published in Peer-reviewed - International Publications/Presentations 1. Soliman AT, Ahmed Abushahin, Khalid Abohezeima, Hany Khalafallah et al. Age Related IGF-I Changes and IGF-I Generation in Thalassemia Major. Pediatric Endocrine Rev ; 2011, 8, 2, 155-159. 2. Soliman AT, Ashraf Adel, Magda Wagdy, Maryam AlAli, Elsaid M. Aziz Bedair . Manifestations of Severe Vitamin D Deficiency in Adolescents: Effects of Intramuscular Injection of a Megadose of Cholecalciferol. J Tropical Pediatrics 2011, http://tropej.oxfordjournals.org/content/early/2010/04/28/tropej.fmq028. 3. Soliman AT, Eldabbagh M. Study of Longitudinal Growth Data of Normal Infants in Qatar: Comparison with WHO and CDC Growth Data. Indian J Pediatr May 2011. /www.indianpediatrics.net/RB300511/RB-346.pdf 4. Fawziya Al-Khalaf, Adel Ismail, Ashraf T. Soliman, David E. C. Cole and Tawfeg Ben-Omran. Neonatal severe hyperparathyroidism: further clinical and molecular delineation. European J Pediatr 2010, DOI: 10.1007/s00431-010-1335-z 5. Ashraf Soliman, Ashraf Adel, et al. Clinical, biochemical and radiological manifestations of severe vitamin D deficiency in adolescents: effects of intramuscular injection of a megadose of cholecalciferol: a case control study. Hormone Research Pediatr 2010, 74 (suppl 3) 448: 136. 6. Ashraf Soliman, Khella A. Linear Growth and IGF-I in Infants and Children with Congenital Cyanotic Heart Disease before vs. after Surgical Intervention. Preseted at The Endocrine Society's Annual Meeting, June 19-22, 2010. San Diego, California. J Clin Endocrinol Metabolism 2010, Suppl. (abstr) 7. Mahmoud Alzyoud; Magda Wagdee; Maryam Al Ali; Ashraf Soliman; Noura Al Hemaidi; Fawzeiah Alkhalaf. Growth response to growth hormone (GH) therapy in children with and without GH deficiency. Horm Res Pediatr 74 (suppl 3) 2010 p2-d1448: 136. 8. Ahmed El-Awwa, Ashraf Soliman, Alsaeed Bedir. Linear Growth And Hormonal And Radiological Manifestations Of A Case Of Neglected Congenital Hypothyroidism: 10 Years Of Follow-Up. Horm Res Pediatr 2010; 74 (suppl 3) p2-d3848: 253. 9. Noura Al Hemaidi ; Ashraf Soliman. Disorders of sex development. Horm Res Pediatr 2010; 74 (suppl 3) R102: 286. 10. Soliman A T , Mohamed El-Dabbagh, Ashraf Adel, Maryam Al Ali, Elsaid M. Aziz Bedair, and Rania K. ElAlaily. Clinical Responses to a Mega-dose of Vitamin D3 in Infants and Toddlers With Vitamin D Deficiency Rickets. J Trop Pediatr 2010 56: 1926. 11. Soliman AT ; Hany Khalafallah; Rasha Ashour Growth and Factors Affecting it in Thalassemia Major. Hemoglobin, 1532-432X, Volume 33, Issue 1, Supplement 1, 2009, Pages S116 – S126 11 12. Ahmed Abushahin, Ashraf Soliman, Amjad Tuffaha. Linear growth at different growth phases in pancreatic sufficient patients with cystic fibrosis. Rivista Italiana di Medicina deil, Adolescenza , 2009, 7; 2: 23-26. 13. Soliman AT, GROWTH and Factors Affecting It In Thalassemia Major. Pediatric Endocrinology Reviews (PER), 6 Supp 1, 2008. 14. Ashraf T Soliman, Ashraf Adel. Linear growth in children with iron-deficiency anemia before versus after treatment. " the 2nd Congress of the European Academy of Paediatric Societies – EAPS, Nice France; October,2008. abstract Arch Dis Child 2009-268-0007-00031 15. Ashraf T Soliman, Mohamed Eldabbagh,Ashraf Adel. Effect of vitamin D therapy on the hematological parameters in children with vitamin D deficiency. the 2nd Congress of the European Academy of Paediatric Societies – EAPS, Nice France; October 2008. abstract Arch Dis Child 2009-268 (suppl) 16. Soliman AT, M M. Al Dabbagh, A H Habboub, A Adel, N Al Humaidy , A Abushahin. Linear Growth in Children with Iron Deficiency Anemia Before and After Treatment Journal of Tropical Pediatrics 2009 55(5):324-327; doi:10.1093/tropej/fmp011 17. A El-Sisia, A Khellaa, M Numana, M Dilwara, A Bhata, Soliman AT. Linear Growth in Relation to the Circulating Concentration of Insulin-like Growth Factor-I and Free Thyroxine in Infants and Children with Congenital Cyanotic Heart Disease Before vs. After Surgical Intervention. Journal of Tropical Pediatrics 2009 55(5):302-306; doi:10.1093/tropej/fmp010 18. Atqah Abdul Wahab, Ashraf Soliman, Mohamed O. A. Rahman. Growth parameters and calcium homeostasis in cystic fibrosis patients with CFTR I1234V mutation Annals of Saudi Medicine, Ann Saudi Med. 2009 Nov–Dec; 29(6): 487–488. doi: 10.4103/0256-4947.57176. 19. Soliman AT, Ashraf Adel, Magda Wagdy, Maryam AlAli. Calcium Homeostasis in 40 Adolescents with Beta Thalassemia Major. Effect of Intramuscular Injection of A Megadose of Cholecalciferol. Pediatric Endocrinology Reviews (PER) 2008;volume 6,supplement1 August: 155-7.1, Arch Dis Child 2008, 93;: pw400 (abstract) 20. Ashraf Soliman, Noora AlHemidi, Magda Wagdy, Maryam AlAli. Use of insulin pump in children with type I diabetes mellitus: Effect on glycemic control and body mass indices. QMJ 2008, 17, 2: 41-43. 21. Soliman AT, Omar M, El Awwa A, Rizk MM, El Alaily RK, Bedair EM. Linear growth, growth-hormone secretion and IGF-I generation in children with neglected hypothyroidism before and after thyroxine replacement. Journal of tropical pediatrics 2008;54(5):347-9. 22. Elsaid M Aziz Bedair , Abbas NE Helmy, Khalid Yakout , Soliman AT. Review of Radiologic Skeletal changes in Thalassemia . Pediatric Endocrinology Reviews (PER) 2008;volume 6,supplement1 August: 123 -6. 23. Soliman AT, Ashraf Adel, Magda Wagdy, Elsaid Bedair. An adolescent boy with thalassemia major presenting with bone pain,numbness,titanic contractions and growth and pubertal delay: panhypopituitarism and combined Vitamin D and 12 parathyroid defects Pediatric Endocrinology Reviews (PER) 2008;volume 6,supplement1 August: 155-7. 24. Ashraf Soliman, Ashraf Adel, Magda Wagdy. Linear growth in children with iron deficiency anemia before and after treatment. Presented in the 2nd congress of the European Academy of Pediatrics (EAP) 2008. Arch Dis Childhood 2008,93, Suppl (Abstract) 25. Soliman AT, Omar M, El Awwa A, Rizk MM, El Alaily RK, Bedair EM. Linear growth, growth-hormone secretion and IGF-I generation in children with neglected hypothyroidism before and after thyroxine replacement. J Trop Pediatr. 2008 Oct;54(5):347-9. 26. Soliman AT, Al Khalaf F, Alhemaidi N, Al Ali M, Al Zyoud M, Yakoot K. Linear growth in relation to the circulating concentrations of insulin-like growth factor I, parathyroid hormone, and 25-hydroxy vitamin D in children with nutritional rickets before and after treatment: endocrine adaptation to vitamin D deficiency. Metabolism. 2008 Jan;57(1):95-102. 27. Fawziya AlKhalaf, Ashraf Soliman, Noora AlHemaidy. Phosphate binder and calcitonin as adjavant therapy in treating hyperphosphatemic tumeral calcinosis. Presented in the European Society of Pediatric Endocrinology (ESPE) conference Helsinki , Finland , 2007. Hormone Research 2007, 68, Suppl 1, (Abstract -PO2-240) 28. Noora AlHemaidy, Ashraf T Soliman. Rickets, osteopenia and bone cyst in an adolescent girl due to 25-cholecalciferol hydroxylase deficiency . Presented in the European Society of Pediatric Endocrinology (ESPE) conference Helsinki , Finland , 2007. Hormone Research 2007,68, Suppl 1, (Abstract R-8) 29. Soliman AT, Omar M, Rizk MM, El Awwa A, AlGhobashy FM. Glycaemic control with modified intensive insulin injections (MII) using insulin pens and premixed insulin in children with type-1 diabetes: a randomized controlled trial. J Trop Pediatr. 2006 Aug;52(4):276-81 30. Ashraf Soliman, Noura ElHemeidy, Maryam AlAli, Fauzia AlKhalaf, Mahmoud Zayoud. Linear growth in relation to the circulating concentrations of insulin-like growth factor-I (IGF-I), parathormone (PTH) and cholecalciferol in children with nutritional rickets before and after treatment. Presented in the European Society of Pediatric Endocrinology (ESPE) conference , Rotterdam July 2006, Hormone Research Pediatr , 2006;65(suppl 4), 134. 31. Soliman AT, Omar M, Al Ali M, Rizk MM, Nasr I, AbolMagd M. Congenital adrenal hyperplasia: family screening using 17-hydroxyprogesterone (17-OHP) response to adrenocorticotropin (ACTH). J Trop Pediatr. 2006 Apr;52(2):147-8. Epub 2005 Oct 28. 32. Soliman A T; Nasr Ibrahim; Thabet Alaa; Rizk Mustafa M; El Matary Wael Human chorionic gonadotropin therapy in adolescent boys with constitutional delayed puberty vs those with beta-thalassemia major. Metabolism: clinical and experimental 2005;54(1):15-23. 33. Ashraf Soliman, Alaa Thabet, Mustfa Rizk, Wael ElMatary. Human chorionic gonadotropin therapy in adolescents with constitutional delayed puberty vs those 13 with thalassemia. Presented at the European Society of Pediatric Endocrinology (ESPE) conference, Hormone Research , 2005, Suppl (Abstr 207) 34. Soliman A T; El-Matary Wael; Fattah Mohamed M Abdel; Nasr Ibrahim S; El Alaily Rania K; Thabet M Alaa. The effect of high-calorie diet on nutritional parameters of children with beta-thalassaemia major. Clinical nutrition (Edinburgh, Scotland) 2004;23(5):1153-8. 35. Soliman A T; Taman Khaled H; Rizk Mohamed M; Nasr Ibrahim S; Alrimawy Hala; Hamido Mohamed S M. Circulating adrenocorticotropic hormone (ACTH) and cortisol concentrations in normal, appropriate-for-gestational-age newborns versus those with sepsis and respiratory distress: Cortisol response to low-dose and standard-dose ACTH tests. Metabolism: clinical and experimental 2004;53(2):209-14. 36. Soliman A T; Omar Magdi; Assem Hala M; Nasr Ibrahim S; Rizk Mohamed M; El Matary Wael; El Alaily Rania K. Serum leptin concentrations in children with type 1 diabetes mellitus: relationship to body mass index, insulin dose, and glycemic control. Metabolism: clinical and experimental 2002;51(3):292-6. 37. Soliman A T; Ramadan M A; Sherif A; Aziz Bedair E S; Rizk M M. Pycnodysostosis: clinical, radiologic, and endocrine evaluation and linear growth after growth hormone therapy. Metabolism: clinical and experimental 2001;50(8):905-11. 14 BIBLIOGRAPHY 1. Vincenzo De Sanctis; Soliman AT, Ahmad Elawwa; Michael Angastiniotis; Androulla Eleftheriou; Christos Kattamis; Mehran Karimi; Mohamed El Kholy; Heba Elsedfy; Mohd Abdel Daem Mohd Yassin; Bernadette Fiscina; et al. Highlights from the First Thalassaemia Forum on Growth and Endocrine Complications in Thalassemia Doha, (October 2-3, 2011). Pediatric endocrinology reviews : PER 2012;9(3):672-9. 2. Ashraf T Soliman; Ahmed Abushahin; Khalid Abohezeima; Hany Khalafallah; Ashraf Adel; Ahmed Elawwa; Naima Elmulla. Age related IGF-I changes and IGF-I generation in thalassemia major. Pediatric endocrinology reviews : PER 2011;8 Suppl 2():278-83. 3. Soliman AT, Yasin M, Awwa A, Vincenzo De Sanctis. Acute Effects of Blood transfusion on Pituitary Gonadal Axis and Sperm Parameters in Adolescents and Young Males with Thalassaemia Major. Fertil Steril ( accepted April, 2012) 4. Ashraf T Soliman, Hatem Abdel Rahman,Awwa A, Hoda M Badran Linear Growth and Circulating Insulin-like growth factor-I (IGF-I) In Children with Tufting Enteropathy Receiving Long Term Total Parental Nutrition (TPN). J Pediatr Gastroenterol Nutr) (2012) PMID 22411267. 5. Ashraf T. Soliman, Muhamed Eldabbagh, Ahmed Elawwa, Rasha Ashour and Wael Saleem. The Effect of Vitamin D Therapy on Hematological Indices in Children with Vitamin D Deficiency. J Trop Pediatr (2012) doi: 10.1093/tropej/fms020 6. Ashraf Soliman, Ashraf Adel, Magda Wagdy, Maryam AlAli , Rania ElAlaily, Said Bedair. CLINICAL MANIFESTATIONS OF VITAMIN D DEFICIENCY (VDD) IN ADOLESCENTS: TWO DIFFERENT PATTERNS OF RADIOLOGICAL CHANGES RELATED TO BODY MASS INDEX, CALCIUM INTAKE AND IGF-I LEVEL. Endocrine Rev 2012 (abstract) 7. Soliman AT Awwa A, “Linear Growth And Neurodevelopmental outcome of Children with Congenital Hypothyroidism (CH) Detected by Neonatal Screening: A Controlled study” Indian J Endocrinol Metab ( accepted 2012) 8. Soliman AT, Desanctis V.“An Approach to Constitutional delay of growth and puberty (CDGP)”(review). Indian J Endocrinol Metab (accepted 2012). 9. Soliman AT, Yassin M, Awwa A. Detection of Glycemic Abnormalities in Adolescents with Beta Thalassemia using Continuous Glucose Monitoring (CGM) and Oral glucose tolerance in Adolescents and Young Adults with β thalassemia major (BTM). Indian J Endocrinol Metab (accepted 2012) 10. Seleem W, Soliman AT, , Elawwa A. Linear growth in Children After Acute Meningitis: A Controlled Study. Arch Dis Child (abstract) 2012 11. Soliman A, Bedair E. The Relation Between Endocrine and Radiological Changes In Adolescents With Vitamin D Deficiency. Endocrine Rev 2012 (abstract) 12. Soliman AT, Yasin M, Awwa A, Vincenzo De Sanctis Detection of Glycaemic Abnormalities in Young Adult Patients with Β Thalassemia Major using Continuous 15 Glucose Monitoring System (CGMS) versus Oral glucose tolerance test (OGTT). Endocrine Rev 2012 (abstract) 13. Desanctis V, Soliman AT. Macro-orchidism.(review). Ped Endocrine Rev (accepted 2012) 14. Soliman AT, Desanctis V, Adel A, Awwa A. Clinical, Biochemical and Radiological Manifestations of Severe Vitamin D deficiency in Adolescents versus Children: Response to Therapy. Georgia Med J ( accepted 212) 15. Awwa A, Soliman AT, desanctis V, Alali M. Continuous Glucose Monitoring, Oral Glucose Tolerance, and Insulin – Glucose Parameters in Adolescents with Simple Obesity. Georgia Med J ( accepted 212) 16. Vincenzo Desanctis, Soliman AT. Hypoparathyroidism (Review) Pediatric Endocrine Rev ( accepted 2012) 17. Soliman AT, Awwa A. The adolescent in the Arabic culture. Rivista Italiana di Medicina dell”Adolescenza. (SIMA) , 2012, (in press) 18. Ahmed El-Awwa, Ashraf Soliman, Bajes Hamad. Continuous glucose monitoring, glucose tolerance and indices of insulin resistance in children on high dose corticosteroid therapy. Horm Res 2011; 76 (suppl 2): 160. 19. Soliman AT, Amal Sabt, El-Awwa A, Haytham Yassin. Effect of a large ventricular septal defect (VSD) on linear growth: A lesson from an affected case who is part of a triplet. Horm Res 2011; 76 (suppl 2): 267. 20. Noura Alhemaidi, Soliman AT, Amal Sabt, El-Awwa A. Complete catch-up growth in a neglected case of hypothyroidism a year after starting therapy. Horm Res 2011; 76 (suppl 2): 281. 21. Amal Sabt, Ashraf Soliman, Noura Alhumaidi, Ahmed Elawwa, Nadra Abdelmajeed. Complete catch-up growth in a case of Johansen Blizzard Syndrome with severe postnatal growth retardation. Horm Res 2011; 76 (suppl 2): 281. 22. Mahmoud Alzyoud, Magda Wegdee , Mariam Al Ali, Ashraf Soliman . Oral Clonidine Test In The Diagnosis Of Growth Hormone Deficiency In Children. Horm Res 2011; 76 (suppl 2) 23. Fawzia Alkhalaf, Maryam Alali, Ashraf Soliman, et al. Continuous subcutaneous insulin infusion (CSII) : a successful mode of therapy for neonatal diabetes (Experience in Qatar). Horm Res 2011, 76: (Suppl 2) 24. Soliman AT, Abushahin A, Abohezeima et al. The age-related changes in serum concentrations of insulin-like growth factor-I (IGF-I) in patients with beta thalassemia major (BTM) and IGF-I generation before and after blood transfusion. Horm Res 2011, 76; (suppl 2) , 190. 25. Soliman AT, Ahmed Abushahin, Khalid Abohezeima, Hany Khalafallah et al. Age Related IGF-I Changes and IGF-I Generation in Thalassemia Major. Pediatric Endocrine Rev 2011, 8, 2, 155-159. 26. Soliman AT, Ashraf Adel, Magda Wagdy, Maryam AlAli, Elsaid M. Aziz Bedair . Manifestations of Severe Vitamin D Deficiency in Adolescents: Effects of 16 Intramuscular Injection of a Megadose of Cholecalciferol. J Tropical Pediatrics 2011, http://tropej.oxfordjournals.org/content/early/2010/04/28/tropej.fmq028. 27. Soliman AT, Eldabbagh M. Study of Longitudinal Growth Data of Normal Infants in Qatar: Comparison with WHO and CDC Growth Data. Indian J Pediatr 2011, 48, 791-96. 28. Fawziya Al-Khalaf, Adel Ismail, Ashraf T. Soliman, David E. C. Cole and Tawfeg Ben-Omran. Neonatal severe hyperparathyroidism: further clinical and molecular delineation. European J Pediatr 2010, DOI: 10.1007/s00431-010-1335-z 29. Ashraf Soliman, Ashraf Adel, et al. Clinical, biochemical and radiological manifestations of severe vitamin D deficiency in adolescents: effects of intramuscular injection of a megadose of cholecalciferol: a case control study. Hormone Research Pediatr 2010, 74 (suppl 3) 448: 136. 30. Wahab, Atqah Abdul; Soliman, Ashraf; Rahman, Mohamed O. A.Growth parameters and calcium homeostasis in cystic fibrosis patients with CFTR I1234V mutation. Annals of Saudi Medicine (2009) 29: 487-488 , January 01, 2009 31. Ashraf Soliman, Khella A. Linear Growth and IGF-I in Infants and Children with Congenital Cyanotic Heart Disease before vs. after Surgical Intervention. Preseted at The Endocrine Society's Annual Meeting, June 19-22, 2010. San Diego, California. J Clin Endocrinol Metabolism 2010, Suppl. (abstr) 32. Mahmoud Alzyoud; Magda Wagdee; Maryam Al Ali; Ashraf Soliman; Noura Al Hemaidi; Fawzeiah Alkhalaf. Growth response to growth hormone (GH) therapy in children with and without GH deficiency. Horm Res Pediatr 74 (suppl 3) 2010 p2-d1448: 136. 33. Ahmed El-Awwa, Ashraf Soliman, Alsaeed Bedir. Linear Growth And Hormonal And Radiological Manifestations Of A Case Of Neglected Congenital Hypothyroidism: 10 Years Of Follow-Up. Horm Res Pediatr 2010; 74 (suppl 3) p2-d3848: 253. 34. Noura Al Hemaidi ; Ashraf Soliman. Disorders of sex development. Horm Res Pediatr 2010; 74 (suppl 3) R102: 286. 35. Soliman A T , Mohamed El-Dabbagh, Ashraf Adel, Maryam Al Ali, Elsaid M. Aziz Bedair, and Rania K. ElAlaily. Clinical Responses to a Mega-dose of Vitamin D3 in Infants and Toddlers With Vitamin D Deficiency Rickets. J Trop Pediatr 2010 56: 1926. 36. Soliman AT ; Hany Khalafallah; Rasha Ashour Growth and Factors Affecting it in Thalassemia Major. Hemoglobin, 1532-432X, Volume 33, Issue 1, Supplement 1, 2009, Pages S116 – S126 37. Ahmed Abushahin, Ashraf Soliman, Amjad Tuffaha. Linear growth at different growth phases in pancreatic sufficient patients with cystic fibrosis. Rivista Italiana di Medicina deil, Adolescenza , 2009, 7; 2: 23-26. 38. Soliman AT, GROWTH and Factors Affecting It In Thalassemia Major. Pediatric Endocrinology Reviews (PER), 6 Supp 1, 2008. 17 39. Ashraf T Soliman, Ashraf Adel. Linear growth in children with iron-deficiency anemia before versus after treatment. " the 2nd Congress of the European Academy of Paediatric Societies – EAPS, Nice France; October,2008. abstract Arch Dis Child 2009-268-0007-00031 40. Ashraf T Soliman, Mohamed Eldabbagh,Ashraf Adel. Effect of vitamin D therapy on the hematological parameters in children with vitamin D deficiency. the 2nd Congress of the European Academy of Paediatric Societies – EAPS, Nice France; October 2008. abstract Arch Dis Child 2009-268 (suppl) 41. Soliman AT, M M. Al Dabbagh, A H Habboub, A Adel, N Al Humaidy , A Abushahin. Linear Growth in Children with Iron Deficiency Anemia Before and After Treatment Journal of Tropical Pediatrics 2009 55(5):324-327; doi:10.1093/tropej/fmp011 42. A El-Sisia, A Khellaa, M Numana, M Dilwara, A Bhata, Soliman AT. Linear Growth in Relation to the Circulating Concentration of Insulin-like Growth Factor-I and Free Thyroxine in Infants and Children with Congenital Cyanotic Heart Disease Before vs. After Surgical Intervention. Journal of Tropical Pediatrics 2009 55(5):302-306; doi:10.1093/tropej/fmp010 43. Atqah Abdul Wahab, Ashraf Soliman, Mohamed O. A. Rahman. Growth parameters and calcium homeostasis in cystic fibrosis patients with CFTR I1234V mutation Annals of Saudi Medicine, Ann Saudi Med. 2009 Nov–Dec; 29(6): 487–488. doi: 10.4103/0256-4947.57176. 44. Soliman AT, Ashraf Adel, Magda Wagdy, Maryam AlAli. Calcium Homeostasis in 40 Adolescents with Beta Thalassemia Major. Effect of Intramuscular Injection of A Megadose of Cholecalciferol. Pediatric Endocrinology Reviews (PER) 2008;volume 6,supplement1 August: 155-7.1, Arch Dis Child 2008, 93;: pw400 (abstract) 45. Ashraf Soliman, Noora AlHemidi, Magda Wagdy, Maryam AlAli. Use of insulin pump in children with type I diabetes mellitus: Effect on glycemic control and body mass indices. QMJ 2008, 17, 2: 41-43. 46. Soliman AT, Omar M, El Awwa A, Rizk MM, El Alaily RK, Bedair EM. Linear growth, growth-hormone secretion and IGF-I generation in children with neglected hypothyroidism before and after thyroxine replacement. Journal of tropical pediatrics 2008;54(5):347-9. 47. Elsaid M Aziz Bedair , Abbas NE Helmy, Khalid Yakout , Soliman AT. Review of Radiologic Skeletal changes in Thalassemia . Pediatric Endocrinology Reviews (PER) 2008;volume 6,supplement1 August: 123 -6. 48. Soliman AT, Ashraf Adel, Magda Wagdy, Elsaid Bedair. An adolescent boy with thalassemia major presenting with bone pain,numbness,titanic contractions and growth and pubertal delay: panhypopituitarism and combined Vitamin D and parathyroid defects Pediatric Endocrinology Reviews (PER) 2008;volume 6,supplement1 August: 155-7. 49. Ashraf Soliman, Ashraf Adel, Magda Wagdy. Linear growth in children with iron deficiency anemia before and after treatment. Presented in the 2nd congress of the 18 European Academy of Pediatrics (EAP) 2008. Arch Dis Childhood 2008,93, Suppl (Abstract) 50. Soliman AT, Omar M, El Awwa A, Rizk MM, El Alaily RK, Bedair EM. Linear growth, growth-hormone secretion and IGF-I generation in children with neglected hypothyroidism before and after thyroxine replacement. J Trop Pediatr. 2008 Oct;54(5):347-9. 51. Soliman AT, Al Khalaf F, Alhemaidi N, Al Ali M, Al Zyoud M, Yakoot K. Linear growth in relation to the circulating concentrations of insulin-like growth factor I, parathyroid hormone, and 25-hydroxy vitamin D in children with nutritional rickets before and after treatment: endocrine adaptation to vitamin D deficiency. Metabolism. 2008 Jan;57(1):95-102. 52. Fawziya AlKhalaf, Ashraf Soliman, Noora AlHemaidy. Phosphate binder and calcitonin as adjavant therapy in treating hyperphosphatemic tumeral calcinosis. Presented in the European Society of Pediatric Endocrinology (ESPE) conference Helsinki , Finland , 2007. Hormone Research 2007, 68, Suppl 1, (Abstract -PO2-240) 53. Noora AlHemaidy, Ashraf T Soliman. Rickets, osteopenia and bone cyst in an adolescent girl due to 25-cholecalciferol hydroxylase deficiency . Presented in the European Society of Pediatric Endocrinology (ESPE) conference Helsinki , Finland , 2007. Hormone Research 2007,68, Suppl 1, (Abstract R-8) 54. Soliman AT, Omar M, Rizk MM, El Awwa A, AlGhobashy FM. Glycaemic control with modified intensive insulin injections (MII) using insulin pens and premixed insulin in children with type-1 diabetes: a randomized controlled trial. J Trop Pediatr. 2006 Aug;52(4):276-81 55. Ashraf Soliman, Noura ElHemeidy, Maryam AlAli, Fauzia AlKhalaf, Mahmoud Zayoud. Linear growth in relation to the circulating concentrations of insulin-like growth factor-I (IGF-I), parathormone (PTH) and cholecalciferol in children with nutritional rickets before and after treatment. Presented in the European Society of Pediatric Endocrinology (ESPE) conference , Rotterdam July 2006, Hormone Research Pediatr , 2006;65(suppl 4), 134. 56. Soliman AT, Omar M, Al Ali M, Rizk MM, Nasr I, AbolMagd M. Congenital adrenal hyperplasia: family screening using 17-hydroxyprogesterone (17-OHP) response to adrenocorticotropin (ACTH). J Trop Pediatr. 2006 Apr;52(2):147-8. Epub 2005 Oct 28. 57. Soliman A T; Nasr Ibrahim; Thabet Alaa; Rizk Mustafa M; El Matary Wael Human chorionic gonadotropin therapy in adolescent boys with constitutional delayed puberty vs those with beta-thalassemia major. Metabolism: clinical and experimental 2005;54(1):15-23. 58. Ashraf Soliman, Alaa Thabet, Mustfa Rizk, Wael ElMatary. Human chorionic gonadotropin therapy in adolescents with constitutional delayed puberty vs those with thalassemia. Presented at the European Society of Pediatric Endocrinology (ESPE) conference, Hormone Research , 2005, Suppl (Abstr 207) 59. Soliman A T; El-Matary Wael; Fattah Mohamed M Abdel; Nasr Ibrahim S; El Alaily Rania K; Thabet M Alaa. The effect of high-calorie diet on nutritional parameters of 19 children with beta-thalassaemia major. Clinical nutrition (Edinburgh, Scotland) 2004;23(5):1153-8. 60. Soliman A T; Taman Khaled H; Rizk Mohamed M; Nasr Ibrahim S; Alrimawy Hala; Hamido Mohamed S M. Circulating adrenocorticotropic hormone (ACTH) and cortisol concentrations in normal, appropriate-for-gestational-age newborns versus those with sepsis and respiratory distress: Cortisol response to low-dose and standard-dose ACTH tests. Metabolism: clinical and experimental 2004;53(2):209-14. 61. Soliman A T; Omar Magdi; Assem Hala M; Nasr Ibrahim S; Rizk Mohamed M; El Matary Wael; El Alaily Rania K. Serum leptin concentrations in children with type 1 diabetes mellitus: relationship to body mass index, insulin dose, and glycemic control. Metabolism: clinical and experimental 2002;51(3):292-6. 62. Soliman A T; Ramadan M A; Sherif A; Aziz Bedair E S; Rizk M M. Pycnodysostosis: clinical, radiologic, and endocrine evaluation and linear growth after growth hormone therapy. Metabolism: clinical and experimental 2001;50(8):905-11. 63. Soliman A T; Madkour A; Galil M A; El Zalabany M; Aziz S M; Ansari B M Growth parameters and endocrine function in relation to echocardiographic parameters in children with ventricular septal defect without heart failure. Journal of Tropical Pediatrics 2001;47(3):146-52. 64. Soliman A T; ElZalabany M M; Salama M; Ansari B M. Serum leptin concentrations during severe protein-energy malnutrition: correlation with growth parameters and endocrine function. Metabolism: clinical and experimental 2000;49(7):819-25. 65. Soliman A T; elZalabany M M; Ragab M; Abdel Fattah M; Hassab H; Rogol A D; Ansari B M. Spontaneous and GnRH-provoked gonadotropin secretion and testosterone response to human chorionic gonadotropin in adolescent boys with thalassaemia major and delayed puberty. Journal Tropical Pediatrics 2000;46(2):7985. 66. A T Soliman, M M Zalabani, M Montaser. Childhood Diabetes in Mediterranean Countries. (review article) Postgraduate Medicine 1999, (Special Supplement: Focus on Diabetes) 22,5: 6-9. 67. A T Soliman, et al. Serum leptin Concentrations During Severe Protein Energy Malnutrition (PEM) : Correlation With Growth Parameters And Endocrine Function. Metabolism 2000, 49, 819-825 68. Soliman A T; elZalabany M M; Mazloum Y; Bedair S M; Ragab M S; Rogol A D; Ansari B M. Spontaneous and provoked growth hormone (GH) secretion and insulinlike growth factor I (IGF-I) concentration in patients with beta thalassaemia and delayed growth. Journal Tropical Pediatrics 1999;45(6):327-37. 69. Soliman A T; elZalabany M M; Bappal B; alSalmi I; de Silva V; Asfour M. Permanent neonatal diabetes mellitus: epidemiology, mode of presentation, pathogenesis and growth. Indian Journal Pediatrics 1999;66(3):363-73. 70. Soliman A T; elZalabany M; Amer M; Ansari B M. Growth and pubertal development in transfusion-dependent children and adolescents with thalassaemia major and sickle cell disease: a comparative study. Journal of Tropical Pediatrics 1999;45(1):23-30. 20 71. Soliman A T; Rajab A; Alsalmi I; Bedair S M. Recessive Robinow syndrome: with emphasis on endocrine functions.Metabolism: clinical and Experimental 1998;47(11):1337-43. 72. Soliman A T; Rajab A; el Zalabany M; alSalmi I; Fattah M A. Defective growth hormone (GH) secretion and short-term treatment in Noonan syndrome. Indian Journal Pediatrics 1998;65(5):741-9. 73. A. El-Nawawy, A. T Soliman, O. El Azzouni. Interleukin-1-beta, tumor necrosis factor-alpha, insulin secretion and oral glucose tolerance in non diabetic siblings of children with IDDM. Indian J Pediatr 1998. 74. Soliman A T; Bererhi H; Darwish A; Alzalabani M M; Wali Y; Ansari B. Decreased bone mineral density in prepubertal children with sickle cell disease: correlation with growth parameters, degree of siderosis and secretion of growth factors. Journal Tropical Pediatrics 1998;44(4):194-8. 75. Soliman A T; El Banna N; Abdel Fattah M; ElZalabani M M; Ansari B M. Bone mineral density in prepubertal children with beta-thalassemia: correlation with growth and hormonal data. Metabolism: clinical and experimental 1998;47(5):541-8. 76. Soliman A T; El Banna N; Ansari B M. GH response to provocation and circulating IGF-I and IGF-binding protein-3 concentrations, the IGF-I generation test and clinical response to GH therapy in children with beta-thalassaemia. European journal of endocrinology 1998;138(4):394-400. 77. Soliman A T; el Banna N; alSalmi I; De Silva V; Craig A; Asfour M. Growth hormone secretion and circulating insulin-like growth factor-I (IGF-I) and IGF binding protein-3 concentrations in children with sickle cell disease. Metabolism: clinical and experimental 1997;46(11):1241-5. 78. Soliman A T; alSalmi I. Growth hormone secretion and serum insulin-like growth factor-I concentration in X-linked hypophosphatemic rickets before and after treatment. Journal of tropical pediatrics 1997;43(4):236-41. 79. Soliman A T; al Salmi I; Asfour M. Mode of presentation and progress of childhood diabetes mellitus in the Sultanate of Oman. Journal of Tropical Pediatrics 1997;43(3):128-32. 80. Soliman AT, el Nawawy A, el Azzoni O, el Ashmawy H, Marzook S, Amer ES.Growth parameters and endocrine function in relation to echocardiographic parameters in children and adolescents with compensated rheumatic heart disease. J Trop Pediatr. 1997 Feb;43(1):4-9. 81. A.T Soliman, I AlSalmi, M Asfour. Incidence and prevalence of insulin-dependent diabetes mellitu in the Sultanate of Oman. International Diabetes Digest UK, 1997. 82. Soliman A T; AlLamki M; AlSalmi I; Asfour M. Congenital adrenal hyperplasia complicated by central precocious puberty: linear growth during infancy and treatment with gonadotropin-releasing hormone analog. Metabolism: clinical and experimental 1997;46(5):513-7. 83. Soliman AT, El-Nawawy AA, El-Azzouni OF, Amer EA, Demian SR, El-Sayed MH High prevalence of islet cell antibody and defective insulin release in children with schistosomiasis. J Trop Pediatr. 1996 Feb;42(1):46-9. 21 84. Soliman A T; Alsalmi I; Asfour M. Hypoinsulinaemia has an important role in the development of oedema and hepatomegaly during malnutrition. Journal of tropical pediatrics 1996;42(5):297-9. 85. Soliman A T; el Banna N; alSalmi I; Asfour M. Insulin and glucagon responses to provocation with glucose and arginine in prepubertal children with thalassemia major before and after long-term blood transfusion. Journal of tropical pediatrics 1996;42(5):291-6. 86. Soliman AT, Al Suweid AR, Gamil H, Khader MM, Afour MG. Glucose tolerance, Cpeptide response to glucagon, and thyroid and adrenal functions in relation to autoantibodies in vitiligo. J Trop Pediatr. 1996 Feb;42(1):60. 87. Soliman A T; abdul Khadir M M. Growth parameters and predictors of growth in short children with and without growth hormone (GH) deficiency treated with human GH: a randomized controlled study. Journal of tropical pediatrics 1996;42(5):281-6. 88. Soliman A T; Rajab A; AlSalmi I; Asfour M G. Empty sellae, impaired testosterone secretion, and defective hypothalamic-pituitary growth and gonadal axes in children with Bardet-Biedl syndrome. Metabolism: clinical and experimental 1996;45(10):1230-4. 89. Soliman A T; Darwish A; alSalmi I; Asfour M. Defective growth hormone secretion and hypogonadism in the new syndrome of congenital hypoparathyroidism, growth failure and dysmorphic features. Indian journal of pediatrics 1996;63(5):679-82. 90. Soliman A T; Rajab A; AlSalmi I; Darwish A; Asfour M. Defective growth hormone secretion in children with pycnodysostosis and improved linear growth after growth hormone treatment. Archives of disease in childhood 1996;75(3):242-4. 91. Soliman A T; Ahmed H I; Asfour M G. Growth parameters, growth hormone (GH) response to clonidine and circulating insulin-like growth factor-I (IGF-I), free thyroxine (FT4) and cortisol concentrations in relation to glycaemic control in children with insulin-dependent diabetes mellitus. Journal of tropical pediatrics 1996;42(4):228-32. 92. Soliman A T; Al-Suwaid A R; Gamil H; Asfour M. Prevalence and significance of Acanthosis nigricans in children and adolescents. Annals of Saudi Medicine 1996;16(4):424-8. 93. Soliman A T; al-Salmi I S; Asfour M G. Epidemiology of childhood insulin-dependent diabetes mellitus in the Sultanate of Oman. Diabetic Medicine : 1996;13(6):582-6. 94. Soliman A T; Alsalmi I; Banna N E; Asfour M. Endocrine aspects of Langerhans cell histiocytosis. Indian Journal of Pediatrics 1996;63(3):402-6. 95. Soliman A T; Alsalmi I; Darwish A; Asfour M G. Growth and endocrine function after near total pancreatectomy for hyperinsulinaemic hypoglycaemia. Archives Disease Childhood 1996;74(5):379-85. 96. Eel-Nawawy A, Soliman AT, El-Azzouni O, Amer el-S, Demian S, el-Sayed M. Effect of passive smoking on frequency of respiratory illnesses and serum immunoglobulin-E (IgE) and interleukin-4 (IL-4) concentrations in exposed children. J Trop Pediatr. 1996 Jun;42(3):166-9 22 97. A T Soliman, B M Ansari. Study of growth and factors affecting it in prepubertal children with chronic hemolytic anaemias (sickle cell disease and beta thalathemia). The Welsh Paediatric Journal (The Journal of the Welsh Paediatric Society)(UK) 1996; 8:59-62. 98. D Green, A T Soliman, B M Ansari. Do children with heriditary spherocytosis have impaired growth? Presented at the 1997 Spring Meeting of the Welsh Paediatric Society, Llandudno, 16-May-1997. (Abstract) The Welsh Paediatric Journal (UK) 1997;9: 38-39. 99. El-Nawawy A, Soliman AT, El Azzouni O, Amer el-S, Karim MA, Demian S, el Sayed M. Maternal and neonatal prevalence of toxoplasma and cytomegalovirus (CMV) antibodies and hepatitis-B antigens in an Egyptian rural area. J Trop Pediatr. 1996 Jun;42(3):154-7 100. Soliman A T; Al Suweid A R; Gamil H; Khader M M; Afour M G. Glucose tolerance, C-peptide response to glucagon, and thyroid and adrenal functions in relation to auto-antibodies in vitiligo. Journal of Tropical Pediatrics 1996;42(1):60. 101. Soliman A T; Madina E H; Morsi M R. Radiological, biochemical, and hormonal changes in malnourished children with rachitic manifestations. Journal Tropical pediatrics 1996;42(1):34-7. 102. A T Soliman, N El Banna, A Darwish, M R Bassiouny, M. Asfour. Growth hormone (GH) response to provocation, insulin-like growth factor-I (IGF-I) generation test, CT scanning of the hypothalamic-pituitary area, and response to GH therapy in children with sickle cell disease. (Presented at the Second Meeting of the European Hematology Association (May 29- June 1, 1996) Paris, France. (Abstract): British J Hematology (UK), 1996, 93, supplement 2, 34, Abst No 132. 103. A. T. Soliman, N El Banna, I AlSalmi, M Asfour. Growth hormone (GH) response to provocation, insulin and insulin-like growth factor-I (IGF-I) concentrations, and IGF-I generation test in children with thalassemia major. Presented at the Second Meeting of the European Hematology Association (May 29June 1, 1996) Paris, France. (Abstract): British J Hematology (UK) 1996; 93, supplement 2,Abst No 131. 104. Soliman A T; Madina E H; Abdel Fattah M; el Zalabany M M; Asfour M; Morsi M R. Nocturnal growth hormone (GH) secretion and GH response to clonidine provocation in children before and after long-term prednisone therapy. Journal of Tropical Pediatrics 1995;41(6):344-7. 105. Soliman AT, Mohsin N, al Hasani M, Elbualy M. Defective clonidine-induced growth hormone secretion and normal thyroid and adrenal functions in prepubertal children with chronic renal insufficiency (CRF). J Trop Pediatr. 1995 Aug;41(4):2214. 106. el-Nanawy AA, el Azzouni OF, Soliman AT, Amer AE, Demian RS, el-Sayed HM. Prevalence of hepatitis-C antibody seropositivity in healthy Egyptian children and four high risk groups. J Trop Pediatr. 1995 Dec;41(6):341-3. 23 107. A T Soliman, M R Bassiony, N ElBanna. Study on some hepatic functions and prevalence of hepatitis-B surface antigenemia in Omani children with sickle cell disease. J Trop Pediatr (UK) 1995; 41: 174-176. 108. A T Soliman, A El Sweid, H Gamil, M Asfour. Glucose tolerance, C-peptide response to glucagon and thyroid and adrenal functions and their relationship to organ specific auto-antibodies in children with vitiligo. Presented at The 3rd International GCC Dermatology Congress, Manama, Bahrain (March 28, 1995). The Gulf Journal of Dermatology 1995, 2,(1): 14-18. 109. Soliman A T; Darwish A; Mohammed S H; Bassiony M R; el Banna N; Asfour M Circulating growth hormone (GH), insulin-like growth factor-I (IGF-I) and free thyroxine, GH response to clonidine provocation and CT scanning of the hypothalamic-pituitary area in children with sickle cell disease. Journal Tropical Pediatrics 1995;41(5):285-9. 110. M. G. Asfour, A. Lambourne, Ashraf Soliman, S. Al-Behlani, D. Al-Asfoor, H King. High Prevalence of Diabetes Mellitus and Impaired Glucose Tolerance in the Sultanate of Oman: Results of the 1991 National Survey. Diabetic Medicine. Volume 12, Issue 12, pages 1122–1125, December 1995. first published online: 30 JUL 2009. 111. Soliman A T; Darwish A; Asfour M G. Empty sella in short children with and without hypothalamic-pituitary abnormalities. Indian Journal Pediatrics 1995;62(5):597-603. 112. Soliman AT, El-Nawawy AA, El-Azzoni OO, Amer SA, Rajab A. SeipBerardinelli lipodystrophy: Report of three cases and their endocrine functions. Ann Saudi Med. 1995 Sep;15(5):501-5. 113. Soliman A T; Bappal B; Darwish A; Rajab A; Asfour M. Growth hormone deficiency and empty sella in DIDMOAD syndrome: an endocrine study. Archives of Disease in Childhood 1995;73(3):251-3. 114. Soliman A T; Khadir M M; Asfour M. Testosterone treatment in adolescent boys with constitutional delay of growth and development. Metabolism: clinical and experimental 1995;44(8):1013-5. 115. A T Soliman, E H Madina, M R Morsi. Radiological, biochemical and hormonal changes in malnourished children with rachitic manifestations. Presented at the Pan Arab Pediatric Societies Congress , Amman, Jordan (April 12-14, 1995). (Abstract): Pediatrics (USA) 1995,95;4, Supplement 2, 9. 116. A T Soliman, A Al-Sweid, H Gamil, M Asfour. Prevalence and metabolic significance of Acanthosis Nigricans in children and adolescents". Presented at the 3rd International Dermatology Conference, GCC League of Dermatology, Manamah, Bahrain, March 26-28, 1995. Presented at the Endocrine Society 77th Annual Meeting, June 14-16th, 1995, Washington DC. (Abstract): (J Clin Endocrinol Metab 1995) . 117. A T Soliman, N El Banna, M Asfour. Insulin and glucagon response to provocation with glucose and arginine in perpubertal children with thalassemia major before and after long-term blood transfusion. Presented at The 5th Conference 24 of The Union of The Arab Pediatric Societies, Jordan, Amman April 12-14, 1995. (Presented at the XXI International Congress of Pediatrics, Cairo, September 10-15, 1995.) (Abstract): Pediatrics (USA), 1995; 95;4, Supplement 2, 9-10. 118. Soliman A T; Bassiouny M R; Elbanna N A. Study of hepatic functions and prevalence of hepatitis-B surface antigenaemia in Omani children with sickle cell disease. Journal of tropical pediatrics 1995;41(3):174-6. 119. Morsy M R; Madina H; Sharaf S A; Soliman A T; Elzalabany M M; Ramadan M A Hyperammonemia in Marasmic children. Journal of tropical pediatrics 1994;40(2):97-9. 120. A T Soliman, M M Abdel-Kader, M Asfour, et al. Growth parameters, growth hormone response to clonidine and circulating insulin-like growth factor-I, free thyroxine and cortisol concentrations in relation to glycemic control in children with IDDM. (Presented at the 30th Annual Meeting of the European Association for the study of diabetes, Dusseldorf, Germany 27th September- 1st October 1994. (Abstract): Diabetologia 1994, 37,(Suppl-1) -A18. 121. A Darweesh , A T Soliman . Empty sella in children with sickle cell disease and growth retardation. Presented at the Royal College of Radiologist Annual Scientific Meeting, London, September 1994. (Abstract) : Clinical Radiology (UK) 1994, 49:10;746 122. A T Soliman, A Darwish, M Asfour. Growth parameters and endocrine functions in children and adults with empty sella syndrome.(Presented at the 5th hGH symposium, 7-10 April, Paris). (Abstract): European J Endocrinol 1994,Suppl 2; 130:144. 123. A T Soliman, E H Madina, M R Morsi et al. Growth hormone (GH) secretion and GH response to clonidine provocation in nephrotic children on long-term alternate day prednisone therapy. (Presented at The Third Congress of The Arab Society of Nephrology and Renal Transplant (Dec. 1993, Riyadh, Saudi Arabia). (Abstract):Saudi Kidney Diseases and Transplant Bulletin 1994;4 (3):S-87. 124. A T Soliman, M M Abdel-Kader, M Asfour, et al. Growth parameters, growth hormone response to clonidine and circulating insulin-like growth factor-I, free thyroxine and cortisol concentrations in relation to glycemic control in children with IDDM. (Presented at the 30th Annual Meeting of the European Association for the study of diabetes, Dusseldorf, Germany 27th September- 1st October 1994. (Abstract): Diabetologia (Germany) 1994, 37,(Suppl-1) -A18. 125. A T Soliman, A Darwish, S Mohammed, M Bassiouny. Circulating growth hormone (GH), insulin-like growth factor-I (IGF-I), GH response to provocation, CT scanning of the hypothalamic pituitary area and response to GH therapy in children with sickle cell disease. Presented at the IIIrd European Congress of Endocrinology, Amsterdam, The Netherland July 1994. (Abstract): European J Endocrinology, 1994, 130, Suppl 2; 195. 126. Hassanein E S; Soliman S I; Hammad H A; Abd-el Aal A; Hatem N L; Soliman A T; el Halawany A. Study on some exocrine and endocrine pancreatic functions in nephrotic children receiving daily and alternate-day corticosteroids. Journal of tropical pediatrics 1993;39(1):37. 25 127. Morsi M R; Madina E H; Anglo A A; Soliman A T. Evaluation of captopril versus reserpine and frusemide in treating hypertensive children with acute poststreptococcal glomerulonephritis. Acta paediatrica: 1992;81(2):145-9. 128. Hassan A H; Abd el Moneim M A; Abd el Aal A A; Abou Aly S A; Ahmed S H; Soliman A T; el Kersh M M. Circulating growth hormone, insulin-like growth factor I, cortisol and free thyroxine in children with schistosomiasis with and without hepatic fibrosis. Journal of Tropical Pediatrics 1991;37(1):25-30. 129. Soliman A T; Hassan A E; Aref M K Endocrine and Amino Acid Changes in Protein Energy Malnutrition (PEM). J Trop Pediatrics 1991, 37,331-333. 130. Hammad H A; el Fattah M M; Moris M; Madina E H; el Abbasy A A; Soliman A T. Study on some hepatic functions and prevalence of hepatitis B surface antigenaemia in Egyptian children with schistosomal hepatic fibrosis. Journal of Tropical Pediatrics 1990;36(3):126-7. 131. A T Soliman, A I Hassan, M K Aref, A D Rogol. Serum cortisol concentrations in children with protein energy malnutrition. (Presented in the 3rd International Pediatric Symposium, Riyadh, 1988). Annals of Saudi Medicine 1989;9:533-537. 132. Soliman A T; Aref M K; Hassan A E. Hormonal changes in protein energy malnutrition. Indian Journal of Pediatrics 1988;55(4):465-9. 133. Madina E H; Soliman A T; Morsi M R. Protein losing enteropathy in the different forms of protein-energy malnutrition. Journal of Tropical Pediatrics 1987;33(5):254-6. 134. Soliman A T; Aref M K; Rogol A D. Arginine-induced insulin and growth hormone secretion in children with nutritional rickets. Journal of Pediatric Gastroenterology and Nutrition 1987;6(4):589-92. 135. Soliman A T; Hassan A E; Aref M K; Hintz R L; Rosenfeld R G; Rogol A D Serum insulin-like growth factors I and II concentrations and growth hormone and insulin responses to arginine infusion in children with protein-energy malnutrition before and after nutritional rehabilitation. Pediatric Research 1986;20 (11):1122-30. 26 Chapters in Books: Soliman AT, Catch-up growthCatch-Up Growth: Role of GH- IGF-I Axis and Thyroxine. In: Preedy VR (ed) Handbook of Growth and Growth Monitoring in Health and Disease. New York: Springer 2012; pp 935-62 . Books and Theses: - Ph D thesis: “ Study of growth and bone mineral density and factors affecting them in children and adolescents with thalassaemia major and sickle cell disease” University of Glamorgan, (School of Applied Sciences, Wales, UK.) (Accepted June 1998) (Treasured by the National British Library, London, 1998) - MD thesis: Endocrine changes and amino-acid patterns in different forms of protein energy malnutrition. Universities of Alexandria (Egypt) and Virginia (USA) , Medical Schools. (Accepted 1987). (Treasured by the University of Virginia , USA and Alexandria University Libraries,1987) - Genetic diseases and syndromes with postnatal growth delay. 2000 The book is an illustrated comprehensive review (200 pages) of genetic diseases and syndromes characterized by postnatal growth abnormalities that have been reported in Arab countries during the last 20 years. - Update in Pediatric Growth and Endocrinology 1999 , 2000. This is the first Pediatric Endocrinology Book in Egypt that extensively reviews the different endocrine and growth problems in the Pediatric age group. (400 pages) 27 - The Endocrinology chapter of (The Essentials of Pediatrics, ed. Prof. Ahmed Madkour, University of Alexandria, 2000 -2004) for undergraduate students. This section includes: growth disorders, thyroid diseases, IDDM, hypoglycemia, adrenal disorders and calcium homeostasis in children. 28 Ongoing Research Topics: 1. Linear growth and development in infants and children with permanent neonatal diabetes mellitus on insulin pump therapy. 2. Study of Longitudinal Growth Data of low Birth Weight Infants in Qatar and Comparison of these Data with Normal Growth Standard. 3. Study of Longitudinal Growth Data of twins and triplets in relation to their midparental height in the first 3 years of life. 4. Treatment of Short Children with Thalassemia Major with IGF-I (Increlex): A pilot Study 5. Continuous glucose monitoring (CGMS) and insulin –glucose indices in children on long term corticosteroid therapy. 6. Continuous glucose monitoring (CGMS) and insulin –glucose indices in children with morbid obesity 7. Continuous glucose monitoring (CGMS) and insulin –glucose indices in children and adolescents with beta thalassemia major. 8. Continuous glucose monitoring (CGMS) and insulin –glucose indices in siblings of children and adolescents with type-1 and type 2 Diabetes Mellitus. 9. Study of linear growth and weight gain and IGF-I changes in infants and children following severe diarrhea. 10. Study of endocrine changes in patients with iron-deficiency anemia during and after treatment. 11. Ultrasonic evaluation of fetal femur and skull in pregnant women with and without vitamin D deficiency during the last trimester. 12. Linear growth and IGF-I changes in epileptic children on long-term anti-epileptic medication, a controlled study. 29 Supervision of MS/MD theses Supervised Research Theses in partial fulfillment for Master and MD Researches in Paediatrics 1. Master thesis Supervision: M Sc Thesis - Supervisor for : Dr Mohamed AbdelDaem Mohamed Yassin (specialist) Department of hematology and bone marrow transplant, HMC. “Detection of Glycemic Abnormalities in Young Adult Patients with Beta Thalassemia Major using Continuous Glucose Monitoring System (CGMS) and Oral glucose tolerance test (OGTT)” . Submitted as partial fulfillment of the requirements for the MSc in Haemoglobinopathy, University of London, 7-2011 2. Master and MD theses supervised and accepted University of Alexandria College of Medicine: 1. Properties of spontaneous growth hormone secretory bursts in prepubertal children with thalassemia major. (MS thesis, University of Alexandria, 1998) 2. Evaluation of pituitary gonadal axis in patients with beta-thalassemia major with delayed puberty. (MS thesis, University of Alexandria, 1998) 3. Testicular function and effect of treatment with human chorionic gonadotrophin in boys with thalassemia and delayed puberty (MS thesis, University of Alexandria, 1999) 4. Assessment of the nutritional status and the effect of high caloric diet on weight gain and insulin-like growth factor-I concentration in children with thalassemia major. (MS thesis, University of Alexandria 1997) 5. Anthropometry of fullterm neonates born in El-Shatby Hospital. ( MS thesis, University of Alexandria, 1997) 6. Growth parameters in relation to severity of VSD in children with compensated congenital heart disease. (MS thesis, University of Alexandria, 1999) 7. Serum leptin concentration in children with insulin-dependent diabetes mellitus : relation to anthropometrical data and glycemic control (MS thesis, 2000) 8. Serum leptin changes in infants with severe protein energy malnutrition before and after nutritional rehabilitation (MD thesis, University of Alexandria 1999) 30 9. Serum leptin concentration in obese children before and after treatment with pseudoephedrine (MS thesis, University of Alexandria, 1998) 10. Study of hypothalamic-pituitary adrenal axis in adolescents with thalassemia major. (MD thesis, University of Alexandria 2000) 11. Study of the effect of short and long-term administration of prednisone on seum leptin concentration , appetite and anthropometry in children with minimal change nephrotic syndrome (MS thesis, University of Alexandria 2000) Examinerships A) Internal Examiner, 1. University of Alexandria , Egypt, including: a. MB B Ch (twice yearly) since 1990 (written, oral and clinical exams) b. Diploma in Pediatrics ( twice yearly) since 1993 (written, oral and clinical exams) c. Master in Pediatrics (twice yearly) since 1993 (written, oral and clinical exams) d. MD in Pediatrics (twice yearly) since 1999 (written, oral and clinical exams) 2. Hamad Medical Center: In-service oral , MCQ and clinical exams for Arab Board Ped. Residents (Once/year) Exams for Pediatric Endocrinology Fellows (yearly) B) External Examiner: (Final Undergraduate Medical Student Exams) 1. Arab University of Bierut, College of Medicine, Lebanon 2. College of Science and Technology, Irbid, Jordan. 3. Gulf University College of Medicine, Bahrain. 31 C) Member : The Promotion Committee of King AbdulAziz University College of Medicine, Saudi Arabia 1. From Assistant to Associate Professor 2. From Associate Professor to Professor Referees: 1. Dr Ashraf Adel, Senior Consultant Pediatrician, Department of Pediatrics, Hamad Medical Center, Doha, Qatart. [email protected] 2. Professor Magdy Omar, Professor of Pediatrics, Alexandria University Children’s Hospital, ElChatby Alexandria , Egypt [email protected] 3. Professor Vincenzo Desanctis, Professor of Pediatrics and Endocrinology, Pediatric Department and Adolescent Outpatient Clinic, Quisisana Hospital, Ferrara, Italy [email protected] Signature: Ashraf Soliman MD PhD FRCP 32
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