Oxidative Stress Contributes to Sex Differences in Blood
Pressure in Adult Growth-Restricted OffspringNovelty and
Significance
by Norma B. Ojeda, Bettye Sue Hennington, Danielle T. Williamson, Melanie L. Hill,
Nicole E.E. Betson, Julio C. Sartori-Valinotti, Jane F. Reckelhoff, Thomas P. Royals,
and Barbara T. Alexander
Hypertension
Volume 60(1):114-122
June 13, 2012
Copyright © American Heart Association, Inc. All rights reserved.
Mean arterial pressure in male control and intrauterine growth-restricted (IUGR) offspring
measured by radiotelemetry in conscious, free-moving animals from 12 weeks of age until 16
weeks of age.
Norma B. Ojeda et al. Hypertension. 2012;60:114-122
Copyright © American Heart Association, Inc. All rights reserved.
Mean arterial pressure in female control and intrauterine growth-restricted (IUGR) offspring
measured by radiotelemetry in conscious, free-moving animals from 12 weeks of age until 16
weeks of age.
Norma B. Ojeda et al. Hypertension. 2012;60:114-122
Copyright © American Heart Association, Inc. All rights reserved.
Renal superoxide production and urinary excretion of F2-isoprostanes in male and female
control and intrauterine growth-restricted (IUGR) offspring treated with the superoxide
dismutase (SOD) mimetic Tempol (1 mmol/L) or vehicle (tap water ad libitum) from 14 weeks to
16 weeks of age.
Norma B. Ojeda et al. Hypertension. 2012;60:114-122
Copyright © American Heart Association, Inc. All rights reserved.
Protein expression of renal antioxidant enzymes catalase (CAT), glutathione peroxidase (GPX),
manganese superoxide dismutase (Mn-SOD), and copper-zinc SOD (Cu-Zn SOD) in adult male
control and intrauterine growth-restricted (IUGR) offspring treated with the SOD mimetic Tempol
(1 mmol/L) or vehicle (tap water ad libitum) for 2 weeks from 14 weeks to 16 weeks of age.
Norma B. Ojeda et al. Hypertension. 2012;60:114-122
Copyright © American Heart Association, Inc. All rights reserved.
Protein expression of renal antioxidant enzymes catalase (CAT), glutathione peroxidase (GPX),
manganese superoxide dismutase (Mn-SOD), and copper-zinc SOD (Cu-Zn SOD) in adult female
control and intrauterine growth-restricted (IUGR) offspring treated with the SOD mimetic Tempol
(1 mmol/L) or vehicle (tap water ad libitum) from 14 weeks to 16 weeks of age.
Norma B. Ojeda et al. Hypertension. 2012;60:114-122
Copyright © American Heart Association, Inc. All rights reserved.
Activity of renal antioxidant enzymes catalase (CAT), copper-zinc superoxide dismutase (Cu-Zn
SOD), and glutathione peroxidase (GPX) in adult male and female control and intrauterine
growth-restricted (IUGR) offspring treated with the SOD mimetic Tempol (1 mmol/L) or vehicle
(tap water ad libitum) from 14 weeks to 16 weeks of age. *P<0.05 vs control. †P<0.05 vs
untreated counterpart. §P<0.05 vs male growth-restricted Tempol treated.
Norma B. Ojeda et al. Hypertension. 2012;60:114-122
Copyright © American Heart Association, Inc. All rights reserved.
Heart rate in male and female control and intrauterine growth-restricted (IUGR) offspring at 16
weeks of age measured by radiotelemetry in conscious, free-moving animals untreated and
treated with Tempol. *P<0.05 vs untreated male control offspring; †P<0.05 vs untreated male
growth-restricted offspring; ‡P<0.05 vs all male offspring.
Norma B. Ojeda et al. Hypertension. 2012;60:114-122
Copyright © American Heart Association, Inc. All rights reserved.