Would you like to know more about what
the EU is doing to fight circulatory diseases,
neurological disorders and cancer?
What is Eicosanox?
Why Eicosanox?
We are a network of Europe’s premier academic
and biotechnology laboratories. The European
Union has granted us more than 10 million Euro
over five years to do basic and clinical research
into the biology of some of our most common
health problems: heart diseases, neurological
disorders and cancer.
Sweden
Karolinska Institutet (Project Coordination), Biolipox AB
Germany
University of Frankfurt, Humbolt University
Together the diseases that we study account for
the majority of deaths in Europe, a great deal of
suffering and enormous costs for society. Our research is finding new ways to fight these diseases
and will lead to the development of new treatments.
This project also supports European research by
improving infrastructure, increasing the exchange
and dissemination of ideas and, by training new scientists for the future
How will we do it?
We study genes and proteins that are involved
in the progression of disease. We focus on the cellular mechanisms that produce and use signalling
molecules called eicosanoids and nitric oxides,
and we are learning more about how these molecules are involved in cardiovascular, cerebral and
neoplastic pathologies. The Eicosanox project is
identifying new ways to interfere with the development of disease, learning how to treat symptoms and how to cure disease.
Italy
G. D’Annunzio University, University of Milan, NicOx S A
Spain
University of Madrid
Great Britain
The Wolfson Institute, UC London
William Harvey Research Institute, QMUL
Fighting disease with
European science
Ireland
University College of Dublin
Canada
Queens University
Signalling pathways consisting
of proteins and chemical mediators are important for normal
health as well as disease. We
want to know how these signals
affect each other and how this
“cross-talk” is important for the
development of the diseases we
study.
Biochemical and molecular properties of key enzymes and receptors
Mechanisms of Eicosanoid and
Nitric Oxide signalling
Functional genomics and proteomics of Eicosanoids and Nitric
Oxide
The role of Eicosanoids and Nitric
Oxide in disease processes
We are learning more about how eicosanoids and nitric oxide are involved in
atherosclerosis, brain disorders and
cancer. Better understanding leads to
better treatments because we can
define more specific targets and thus
avoid unnecessary side-effects.
We study the structure, function
and regulation of key enzymes
and receptors which helps us understand protein function and
design new drugs. Biochemical
characterization of protein interactions, modulation and modification helps us identify new drug
targets.
New strategies for therapeutic intervention and drug design
Profiling the expression of genes in various
tissues allows us to target genes that are
turned on or off as a disease progresses. New
genes that can be linked to the development
of disease are important and valuable tools
for finding new treatments and cures. The
proteins coded by these genes need to be
identified and thoroughly examined to understand how they can be used to slow
down or stop the disease progression.
Learning about disease and molecules involved is only part of the solution. Eicosanox will also help develop and evaluate new drugs, and
work to reduce the side-effects of existing treatments. We will do this
not only at the cellular and molecular levels, but also in patients as
we explore individual patients responses to various therapies.
Would you like to know more about our work, or perhaps start a collaboration?
The offices of the coordinator will be happy to provide contact information for our partners
and discuss any ideas for new work. You can also drop by our web site.
Eicosanoids and Nitric Oxide:
Mediators of Cardiovascular, Cerebral
And Neoplastic Diseases
Project Coordinator:
Phone:
Fax:
E-mail:
Address:
Prof. Jesper Z. Haeggström
+46 8 524 87612
+46 8 736 0439
[email protected]
Karolinska Institutet
Dept. of Medical Biochemistry and Biophysics
Physiological Chemistry II
S-171 77 Stockholm
Sweden
WWW.EICOSANOX.ORG