RSTB_367_1602_Cover.qxd
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volume 367
. number 1602 . pages 2511–2668
The evolution of protein phosphorylation
Papers of a Theme Issue compiled and edited by Tony Hunter and Tony Pawson
Preface
Preface
T. Hunter & T. Pawson
2512
Articles
Why nature chose phosphate to modify proteins
T. Hunter
2513
Evolution of the eukaryotic protein kinases as dynamic molecular switches
S. S. Taylor, M. M. Keshwani, J. M. Steichen & A. P. Kornev
2517
Design principles underpinning the regulatory diversity of protein kinases
K. Oruganty & N. Kannan
2529
Modular evolution of phosphorylation-based signalling systems
J. Jin & T. Pawson
2540
Evolution of SH2 domains and phosphotyrosine signalling networks
B. A. Liu & P. D. Nash
2556
2574
Mutational properties of amino acid residues: implications for evolvability of phosphorylatable
residues
P. Creixell, E. M. Schoof, C. S. H. Tan & R. Linding
2584
Protein abundance is key to distinguish promiscuous from functional phosphorylation based
on evolutionary information
E. D. Levy, S. W. Michnick & C. R. Landry
2594
An evolutionary perspective on the kinome of malaria parasites
E. Talevich, A. B. Tobin, N. Kannan & C. Doerig
2607
Diversity, classification and function of the plant protein kinase superfamily
M. D. Lehti-Shiu & S.-H. Shiu
2619
Bacterial tyrosine kinases: evolution, biological function and structural insights
C. Grangeasse, S. Nessler & I. Mijakovic
2640
Structural and mechanistic insights into the bifunctional enzyme isocitrate dehydrogenase
kinase/phosphatase AceK
J. Zheng, S. P. Yates & Z. Jia
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2656
volume 367
number 1602
pages 2511–2668
In this Issue
The evolution of protein phosphorylation
Papers of a Theme Issue compiled and edited by Tony Hunter and Tony Pawson
The evolution of protein phosphorylation
Protein kinases display minimal interpositional dependence on substrate sequence: potential
implications for the evolution of signalling networks
B. A. Joughin, C. Liu, D. A. Lauffenburger, C. W. V. Hogue & M. B. Yaffe
Phil. Trans. R. Soc. B | vol. 367 no. 1602 pp. 2511–2668 | 19 Sep 2012
19 September 2012
ISSN 0962-8436
The world’s first science journal
rstb.royalsocietypublishing.org
Published in Great Britain by the Royal Society,
6–9 Carlton House Terrace, London SW1Y 5AG
19 September 2012