Cellular Respiration: Harvesting Chemical Energy All the energy in all the food you eat can be traced back to sunlight If you exercise too hard, your muscles shut down from a lack of oxygen FEELING THE “BURN” When you exercise: Muscles need energy in order to perform work Your cells use oxygen to release energy from the sugar glucose Aerobic metabolism (oxygen is present) When enough oxygen reaches cells to support energy needs Anaerobic metabolism (oxygen is not present) When the demand for oxygen outstrips the body’s ability to deliver it Energy Flow in the Biosphere Fuel molecules in food represent solar energy Energy stored in food can be traced back to the sun Animals depend on plants to convert solar energy to chemical energy This chemical energy is in the form of sugars and other organic molecules Photoautotrophs “Self-feeders”: Undergo photosynthesis Plants and other organisms that make all their own organic matter from inorganic nutrients Heterotrophs “Other-feeders” rely on autotrophs for energy Humans and other animals that cannot make organic molecules from inorganic ones Plants - Autotrophs: self-producers. Animals - Heterotrophs: consumers. Sunlight energy Ecosystem Photosynthesis (in chloroplasts) Glucose Oxygen Carbon dioxide Water Cellular respiration (in mitochondria) for cellular work Heat energy Cellular Respiration is the step-wise release of energy from carbohydrates and other molecules Energy from these reactions is used to synthesize ATP molecules This is an aerobic process—it requires oxygen Don’t mix up Cellular Respiration and Respiratory Breathing! Cellular respiration and breathing are closely related Cellular respiration requires a cell to exchange gases with its surroundings Breathing exchanges these gases between the blood and outside air Breathing Lungs Muscle cells Cellular respiration Figure 6.4 The Overall Equation for Cellular Respiration A common fuel molecule for cellular respiration is glucose Glucose This is the overall equation for what happens to glucose during cellular respiration Oxygen Carbon dioxide Water Energy Catabolic or anabolic? The Role of Oxygen in Cellular Respiration During cellular respiration, hydrogen and its bonding electrons change partners Hydrogen and its electrons go from sugar to oxygen, forming water Why? Oxygen is much more electronegative than carbon (it’s a good tief of electrons!) Review The loss of electrons (or hydrogen) during a redox reaction is called ________________ The acceptance of electrons during a redox reaction is called _____________ LEO GER Oxidation [Glucose loses electrons (and hydrogens)] Glucose Oxygen Carbon dioxide Water Reduction [Oxygen gains electrons (and hydrogens)] The Metabolic Pathway of Cellular Respiration Cellular respiration is an example of a metabolic pathway A series of chemical reactions in cells –building or degradation process All of the reactions involved in cellular respiration can be grouped into four main stages Glycolysis Pyruvate oxidation The Krebs cycle Electron transport chain Breakdown of Cellular Respiration Four main parts (reactions): 1. Glycolysis (splitting of sugar) cytoplasm, just outside of mitochondria. 2. Pyruvate Oxidation migration from cytoplasm to matrix. Breakdown of Cellular Respiration 3. Krebs Cycle (Citric Acid Cycle) mitochondrial matrix 4. Electron Transport Chain (ETC) and Oxidative Phosphorylation Also called Chemiosmosis inner mitochondrial membrane Goals of Cellular Respiration To break the bonds between the six carbon atoms in glucose (this creates 6 molecules of carbon dioxide) To move hydrogen atom electrons from glucose to oxygen to form 6 molecules of water While the various reactions take place, free energy is released from the bonds as they break; thus the cell works to trap as much of the released free energy in the form of ATP A Road Map for Cellular Respiration cytoplasm Mitochondrion High-energy electrons carried mainly by NADH High-energy electrons carried by NADH Glycolysis Glucose 2 Pyruvic acid Krebs Cycle Electron Transport Substrate-Level Phosphorylation ATP is formed directly when an enzyme transfers a phosphate group from a substrate to ADP Oxidative Phosphorylation Different from substrate-level phosphorylation ATP is formed INDIRECTLY via other redox reactions (i.e. NAD+ and FADH) Oxidative Phosphorylation NAD+ and FADH •Oxidation-reduction reactions use NAD+ or FADH (nicotinamide adenine dinucleotide, flavin adenine dinucleotide) which are coenzymes (A molecule that binds to an enzyme and is essential for its activity, but is not permanently alteredNAD+ by the accepts reaction). two •When a metabolite is oxidized, NAD+ electrons and FAD can be used over andion over(H+) again. plus a hydrogen andThey NADH are likeresults, trucks that carry and deliver where its leaving a free H+ energy ion in the cell needed. - NAD+ is reduced to NADH •Conversely, NADH can also reduce a metabolite by giving up electrons - NADH is oxidized to NAD+ Oxidative Phosphorylation NAD+ and FADH Did you Know? NAD+ is a derivative of vitamin B3 (also known as niacin or niacinamide) An Overview Glycolysis = ‘Sugar-breaking’ Where? • Occurs in the cytoplasm What? • It is the breakdown of glucose Start with: glucose End with: two pyruvate molecules. • Glycolysis is universally found in all organisms. • Glycolysis does not require oxygen (anaerobic). Let’s Look over the Steps of Glycolysis… Follow along and fill in your handout! Keep track of the inputs and outputs (ATP, NADH, H2O, ADP etc.) in a table like this: INPUT Net Products OUTPUT So let’s do some accounting… INPUT OUTPUT •2 ATP •2 NADH •4 ATP •2 H2O •2 Pyruvate Net Products •2 ATP •2 NADH •2 H2O •2 Pyruvate The Wonderful World of the Mitochondria 2. Pyruvate Oxidation Occurs when Oxygen is present (aerobic) Mitochondrial 2 Pyruvate (3C) molecules are Matrix transported through the mitochondria membrane to the matrix and is converted to 2 Acetyl CoA (2C) molecules cytoplasm 2 CO2 C C C Matrix C-C 2 Pyruvate 2 NAD+ 2NADH 2 Acetyl CoA Pyruvate Oxidation •This stage connects glycolysis to the Krebs cycle •Pyruvate is converted to acetyl CoA and CO2 is released •During this oxidation reaction, NAD+ is converted to NADH + H+ •This reaction occurs twice per glucose molecule Review: Cellular Respiration Glycolysis Glucose Pyruvate Pyruvate Oxidation Pyruvate Acetyl-CoA Acetyl-CoA ATP Krebs Cycle Pyruvate Oxidation Cytoplasm Mitochondrion Matrix O O O C Pyruvate Transport C O Protein H C H H Krebs Cycle Redox Reaction O O C Pyruvate C Decarboxylase Acetic Acid H Group C H CoA H C O Acetyl-CoA H C H H H H NAD+ S Reduced NADH + H+ S CoA Summary of Pyruvate Oxidation Pyruvate oxidation occurs twice to use one molecule of glucose One molecule of NADH produced One molecule of CO2 is released The product of pyruvate oxidation is acetylCoA In cellular respiration, acetyl-CoA enters Krebs Cycle to eventually produce molecules of ATP CoA activates the acetyl group for the first reaction in the Krebs Cycle Homework Review Glycolysis and Transition reaction (Pyruvate oxidation) More notes to follow……
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