Improve the animals gut health
and performance
Jaco Eissen, PhD
Business Manager innovation Selko Feed Additives
26 October 2015
Index
Introduction
Challenge
Solution
Value
proposition
Benchmark
3
Annual Deaths Attributable to AMR by 2050
will exceed other causes 2050
Source: The Review on Antimicrobial Resistance, December 2014
4
Annual AMR-Related Deaths by 2050 will hit
Asia and Africa the hardest
Source: The Review on Antimicrobial Resistance, December 2014
Less microbiota diversity after weaning
Pre-weaning
Post-weaning
Jejunum
Colon
Higher proportion of Lactobacillus reuteri post-weaning
Reduced diversity
Nutreco R&D, 2011
Index
Introduction
Challenge
Solution
Value
proposition
Benchmark
Presan’s integrated approach
to support gut health – features and benefits
Improves microbial balance
Improve gut wall
integrity and
recovery intestinal
cells
Reduces the need
for antibiotics
- Phenolic compound
- Slow release C12
Increase diversity
microbiota
- Target release butyrate
- Blend of MCFA and organic acids
Reduces broad spectrum
range of bacteria
Maintain healthy status of gut
Effect of Presan in the intestine
Only Gramnegative
Also Gram²
postive
9
Selko pH forms a strong team with Presan
Product Improve digestion
focus • Reduce pH in
Product
Stabilise microbiota
Boost intestinal barrier
• Increase diversity
• Improve tight junctions
crop/stomach
Gram negative bacteria
Gram negative bacteria / Gram positive bacteria
Gram negative bacteria / Gram positive bacteria
Preventive synergistic approach
Gram negative bacteria / Gram positive bacteria
Extra power
against pathogens
Presan development:
cutting edge technologies used
Samples from animals
Microflora profiling
Bio-informatics
and
data analysis
Bar-coded Pyrosequencing
Bar-coded Pyrosequencing for microbiota profiling
11
Presan animation
| 12
Presan stabilises microbiota
throughout small intestine
Improves microbial
balance
Trial details report 2
Animal: weaned piglets
Sampling sites: Duodenum/jejunum & ileum
Duration: 2 weeks
Sampling material: digesta
Conditions: Hygiene challenge at SRC, Netherlands
Techniques used: qPCR and Pyrosequencing
Source::NIZO Food Research and SRC, The Netherlands 2011
13
Presan stabilises microbiota in jejunum
Improves microbial
balance
Representative Pyrosequencing
profiles from group on D7
Control
Presan™
Trial details report 1
Animal: weaned piglets
Sampling sites: jejunum
Duration: 1 week post weaning
Sampling material: digesta
Conditions: Research farm SRC, Netherlands
Techniques used: qPCR and Pyrosequencing
Source::NIZO Food Research and SRC, The Netherlands 2011
14
Importance of healthy gut barrier
1. tight junctions

Importance of healthy gut barrier
2.inflammation
Interleukines (IL) are
indicators of
inflammation
Presan may improve tight junction quality
May boost gut wall
integrity
IL-1β = Interleukin 1β
Trial details
Animal: pigs
Sampling sites: jejunal tissue
IL8 = Interleukin 8
- Both are important mediators of inflammatory responses Duration: 10 days & challenged with gut barrier stress at D7
Conditions: high health
Source:: INRA, France and Nutreco R&D, The Netherlands 2010
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Index
Introduction
Challenge
Solution
Value
proposition
Benchmark
Value proposition
Knowledge is knowing a
tomato is a fruit.
Wisdom is not putting it in
a fruit salad.
Value proposition
Microbial balance
-FX
Reducing need
for AMGP
• Less microbiota
• More diversity
Gut integrity
• Less inflammation
• Stronger tight
junctions
Reducing need
for
antibiotics/ZnO
Improving
animal
performance
ADG
FCR
Uniformity
20
Presan™
• Supports tight junction quality
Boosts gut wall integrity
Maximising synergistic effect
=
Maximum return on intestine
FY
FX
Stabilises microbiota
•
Improves microbial balance in small intestine
1. Presan in piglets
Healthy gut
Lower need for antibiotics
Better consistency of faeces
Higher feed intake
Less small piglets
Higher uniformity
22
Presan improves piglet performance
significantly
Trial details report 9
Animal: weaned piglets
Duration: 6weeks
Conditions: commercial conditions
23
Source:Agreseach, Canada 2011
Presan improves uniformity
Variation coefficient:
- 1 kg: 11% reduction
- 2 kg: 13% reduction
Final body weight
Control
Presan-FX
1kg/ton
Presan-FX
2kg/ton
Trial details report 9
Animal: weaned piglets
Duration: 6 weeks
Conditions: commercial conditions
24
Source:Agreseach, Canada 2011
Presan: consistently improved ADG
and feed efficiency in piglets
•
•
•
•
Meta-analyses of 9 controlled R&D studies
Presan versus control diet without antibiotics, ZnO
Data of in total 2310 piglets included
No bias, all studies are included
ADG, g/day
Feed intake, g/day
Feed Conversion Ratio
+ 5%
p < 0.001
+ 4%
p = 0.029
- 2%
p < 0.001
| 25
Presan: Economical value for Farmers / Integrators
Performance piglets: Improvement fecal consistency/ ADG / FCR
€€ value
value piglet
piglet
€/piglet
€/piglet
€€ 1,50
1,50
€€ 1,00
1,00
€€ 0,50
0,50
€€ -0,33
-0,33
€€ 1,08
1,08
€€ 0,64
0,64
€€ 0,00
0,00
-€
-€ 0,50
0,50
€€ -0,11
-0,11
-€
-€ 1,00
1,00
Presan
Presan investment
investment
Extra
Extra feed
feed cost
cost
Weight-Mortality
Weight-Mortality
Net
Net value/piglet
value/piglet
-€
-€ 1,50
1,50
Average ROI > 4 *
* Economical data based on local feed & swine prices
* Data based on statistical significant trails, but outcome varies per situation
*
Presan fits in strategy to reduce zinc oxide
Treatment
Weaning-D8*
D9-20**
D21-40
Control
3100 ppm ZnO
3100 ppm ZnO
3100 ppm ZnO
Presan-low
3100 ppm ZnO
1550 ppm ZnO
+ 1 kg Presan
No ZnO
+ 1 kg Presan
Presan-high 3100 ppm ZnO
1550 ppm ZnO
+ 2 kg Presan
No ZnO
+ 2 kg Presan
*All treatments received
additionally colistine in diet.
** All treatments received
additionally amoxycillin in diet.
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Nutreco R&D, 2012
…. and strong financial results with largest profit
benefit for 2 kg Presan
Control
Presan 1kg/ton Presan 2 kg/ton
ZnO & Presan cost (€/piglet)
€ 0.15
€ 0.08
€ 0.15
Feed costs (€)
€ 8.42
€ 9.03
€ 9.18
Value per piglet (end trial)
€ 24.00
€ 25.75
€ 26.54
Value piglet - feed costs
€ 15.43
€ 16.64
€ 17.21
Additional value compared to
control (€/piglet)
€ 0.00
€ 1.21
€ 1.79
Difference ZnO/Presan costs
compared to control (€/piglet)
€ 0.00
-€ 0.07
€ 0.00
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*
29
Presan improves FE in AGP free diets
0,68
ab
FE (G/F), d.1-28
0,67
0,66
0,65
NC
0,64
PC (AGP)
0,63
ab
Presan
b
0,62
0,61
FE (G/F)
China 2015, Sichuan Agri University, piglets
AGP: 5 ppm colistine sulphate + 5 ppm olaquindox
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2. Presan in lactating sows
for sow and piglet
Healthy gut
Higher feed intake
Less backfat loss
Higher milk production
• Supports natural
immunity
• Higher feed intake
Healthier weaned piglets
• Healthy gut microbiota
• Higher feed intake
• Higher weaning weight
Healthy sow
• Lower culling rate
• Less non productive days
31
Higher feed intake in lactating sows
results in higher weaning weights
Animal: sows and piglets
Duration: 4weeks/sow
Conditions: reasonably good health status
Trial details report 17
32
Source:Agreseach, Canada 2011
Higher feed intake in lactating sows
results in higher weaning weights
Prercentage per litter
Piglet weaning weight categories
50%
45%
40%
35%
30%
25%
20%
15%
10%
5%
0%
Control
P<0.05
P<0.05
<4.0
Animal: sows and piglets
Presan-FX
4.0-5.0
5.0-6.0
6.0-7.0
Piglet Weaning Weight (kg)
Duration: 4weeks/sow
>7.0
Conditions: reasonably good health status
Trial details report 17
33
Source:Agreseach, Canada 2011
Presan sows : Pig Progress
| 34
3. Presan in G/F pigs
Healthy gut
Replacement AGP
Lower need for antibiotics
Better consistency of faeces
Lower mortality
Better FE, ADG
Better performance
35
Meta-analysis Presan-FX in finishing pigs
Presan-FX can replace AGP in finishing diets:
• no adverse effect on performance
• 4% improvement in ADG
• 6% reduction in FG
• Cost neutral (potential reduction)
Presan-FX (with AGP) improves performance:
• 4% improvement in ADG
• -0.10 reduction in FG
• 33% reduction in mortality
• Additional cost $1.60/pig (due to high AGP + Elarom
feed cost)
36
Our advice
Feed & water application
Presan-FX
Sows gestation
Sows lactation
Piglets preweaning
Piglets postweaning phase 1 (week 1)
Piglets postweaning phase 2 (week 2-3)
Piglets postweaning phase 3 (week 4-6)
Growing pigs (25-40 kg)
Finishing pigs (40 kg – finish,eg. 110 kg)
& Selko-pH*
(to be applied in standard
feed program): kg/mt
L/1000 L (to be applied in
standard feed program)
Zinc oxide
0
1
2
2
2
2
2
1
2
1
0
2
2
2
2
0/2**
(3000-2500 ppm)
(1500 ppm)
0 ppm
-
*Dosage based on titration
(buffercapacity of water)
** in case of problems
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Healthy growth guide
Feed
management
Q1 ‘16
Health
management
•Antibiotic programs
•Vaccination programs
•Additives to support animal
health
•Scoring gut health
•Measuring accurate
nutritional value (NIR)
•Quality of feed & raw
materials
•Composition irt age animals
•Physical feature of feed
•Feed additives to enhance
digestion
Farm
management
•Datamanagement
•Housing system
•Biosecurity
•Cleaning & desinfection
•Health status of animals at
arrival
•Water management
•Climate control
•Stocking density
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Index
Introduction
Challenge
Solution
Value
proposition
Benchmark
Presan in the world of organic acids
and MCFA’s
41
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