The Effects of Mitral Regurgitation Alone Are Sufficient for
Leaflet Remodeling
by Elizabeth H. Stephens, Tom C. Nguyen, Akinobu Itoh, Neil B. Ingels, D. Craig
Miller, and K. Jane Grande-Allen
Circulation
Volume 118(14 suppl 1):S243-S249
September 30, 2008
Copyright © American Heart Association, Inc. All rights reserved.
Figure 1. Intraoperative picture of hole punch made in the posterior leaflet of the mitral valve.
Elizabeth H. Stephens et al. Circulation. 2008;118:S243S249
Copyright © American Heart Association, Inc. All rights reserved.
Figure 2. A, Diagram showing location from which AML cross-sections were taken.
Elizabeth H. Stephens et al. Circulation. 2008;118:S243S249
Copyright © American Heart Association, Inc. All rights reserved.
Figure 3. A, Microstructure of a mitral valve anterior leaflet (originally stained with Movat
pentachrome) showing different regions and layers.
Elizabeth H. Stephens et al. Circulation. 2008;118:S243S249
Copyright © American Heart Association, Inc. All rights reserved.
Figure 4. A, MR grade of HOLE versus CTRL. B, Sample echo image of regurgitant jet in a HOLE
animal.
Elizabeth H. Stephens et al. Circulation. 2008;118:S243S249
Copyright © American Heart Association, Inc. All rights reserved.
Figure 5. Staining intensity of matrix components in HOLE and CTRL animals. *P<0.05;
†P=0.022R; ‡P=0.081.
Elizabeth H. Stephens et al. Circulation. 2008;118:S243S249
Copyright © American Heart Association, Inc. All rights reserved.
Figure 6. A, MMP-9 expression in various regions of the valve (P=0.021).
Elizabeth H. Stephens et al. Circulation. 2008;118:S243S249
Copyright © American Heart Association, Inc. All rights reserved.
Figure 7. Background elastin staining (overall P=0.023).
Elizabeth H. Stephens et al. Circulation. 2008;118:S243S249
Copyright © American Heart Association, Inc. All rights reserved.