Sirtuin 1 Retards Hyperphosphatemia-Induced
Calcification of Vascular Smooth Muscle Cells
by Aya Takemura, Katsuya Iijima, Hidetaka Ota, Bo-Kyung Son, Yuki Ito, Sumito
Ogawa, Masato Eto, Masahiro Akishita, and Yasuyoshi Ouchi
Arterioscler Thromb Vasc Biol
Volume 31(9):2054-2062
August 17, 2011
Copyright © American Heart Association, Inc. All rights reserved.
Presence of senescent vascular cells colocalized with calcification in aortic media of renal
failure rats.
Aya Takemura et al. Arterioscler Thromb Vasc Biol.
2011;31:2054-2062
Copyright © American Heart Association, Inc. All rights reserved.
Inorganic phosphate (Pi) stimulation induces cellular senescence in vascular smooth muscle
cells (SMCs) via its cotransporter.
Aya Takemura et al. Arterioscler Thromb Vasc Biol.
2011;31:2054-2062
Copyright © American Heart Association, Inc. All rights reserved.
Inorganic phosphate (Pi) stimulation leads to sirtuin 1 (SIRT1) downregulation and subsequent
p21 activation.
Aya Takemura et al. Arterioscler Thromb Vasc Biol.
2011;31:2054-2062
Copyright © American Heart Association, Inc. All rights reserved.
Modulation of sirtuin 1 (SIRT1) affects inorganic phosphate (Pi)–induced senescent phenotypic
change and calcification in smooth muscle cells (SMCs).
Aya Takemura et al. Arterioscler Thromb Vasc Biol.
2011;31:2054-2062
Copyright © American Heart Association, Inc. All rights reserved.
Augmentation of senescence-related smooth muscle cell (SMC) calcification by sirtuin 1 (SIRT1)
knockdown in association with osteoblastic phenotypic change and prevention of inorganic
phosphate (Pi)–induced changes by p21 knockdown.
Aya Takemura et al. Arterioscler Thromb Vasc Biol.
2011;31:2054-2062
Copyright © American Heart Association, Inc. All rights reserved.
High sensitivity of smooth muscle cells (SMCs) with replicative senescence to inorganic
phosphate (Pi)–induced calcification.
Aya Takemura et al. Arterioscler Thromb Vasc Biol.
2011;31:2054-2062
Copyright © American Heart Association, Inc. All rights reserved.