Direct Measurement of Cardiac Na+ Channel
Conformations Reveals Molecular Pathologies of Inherited
Mutations
by Zoltan Varga, Wandi Zhu, Angela R. Schubert, Jennifer L. Pardieck, Arie
Krumholz, Eric J. Hsu, Mark A. Zaydman, Jianmin Cui, and Jonathan R. Silva
Circ Arrhythm Electrophysiol
Volume 8(5):1228-1239
October 20, 2015
Copyright © American Heart Association, Inc. All rights reserved.
Ionic and gating currents from the wild-type large fluorescence signal (WT-LFS) construct.
Zoltan Varga et al. Circ Arrhythm Electrophysiol.
2015;8:1228-1239
Copyright © American Heart Association, Inc. All rights reserved.
V215C (DI-large fluorescence signal [LFS]) ionic currents and fluorescence.
Zoltan Varga et al. Circ Arrhythm Electrophysiol.
2015;8:1228-1239
Copyright © American Heart Association, Inc. All rights reserved.
DII-large fluorescence signal (LFS; S805C) ionic currents and fluorescence.
Zoltan Varga et al. Circ Arrhythm Electrophysiol.
2015;8:1228-1239
Copyright © American Heart Association, Inc. All rights reserved.
DIII-large fluorescence signal (LFS; M1296C) ionic currents and fluorescence.
Zoltan Varga et al. Circ Arrhythm Electrophysiol.
2015;8:1228-1239
Copyright © American Heart Association, Inc. All rights reserved.
DIV-large fluorescence signal (LFS; S1618C) ionic currents and fluorescence.
Zoltan Varga et al. Circ Arrhythm Electrophysiol.
2015;8:1228-1239
Copyright © American Heart Association, Inc. All rights reserved.
DII-large fluorescence signal (LFS)-A735V and DII-LFS-G752R Brugada syndrome mutants.
Zoltan Varga et al. Circ Arrhythm Electrophysiol.
2015;8:1228-1239
Copyright © American Heart Association, Inc. All rights reserved.
Comparison of valence-weighted F–V functions with Q–V functions.
Zoltan Varga et al. Circ Arrhythm Electrophysiol.
2015;8:1228-1239
Copyright © American Heart Association, Inc. All rights reserved.