From: Glucagon Receptor Agonists and Antagonists Affect the Growth of the Chick Eye: A Role for Glucagonergic
Regulation of Emmetropization?
Invest. Ophthalmol. Vis. Sci.. 2005;46(11):3922-3931. doi:10.1167/iovs.04-1026
Figure Legend:
High concentrations of [Lys17,18,Glu21]-glucagon-NH2 alter rods in the chick retina. Micrographs of retinas from eyes,
open or form deprived, treated with saline or a dose of [Lys17,18,Glu21]-glucagon-NH2 that significantly reduced ocular
growth and caused a hyperopic shift in refraction (10−5 M in the syringe, five daily injections). Each pair shows (left)
histologic stain with toluidine blue and (right) darkfield immunofluorescence for rhodopsin. (a) Open, saline; (b) open
[Lys17,18,Glu21]-glucagon-NH2; (c) form-deprived, saline; and (d) form-deprived, [Lys17,18,Glu21]-glucagon-NH2. RPE,
retinal pigment epithelium; PRL, photoreceptor layer. Scale bar, 50 μm (d1 holds also for a1, b1, c1; d2 holds for a2, b2,
c2).of download: 7/31/2017
Date
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