-REACTIONS
#Glycolysis and Gluconeogenesis
Mlut_13470 :
GLC + POLYP -> G6P + nPOLYP
Mlut_13470 :
bDGLC + POLYP -> bDG6P + nPOLYP
Mlut_05040 :
GLC <-> bDGLC
Mlut_11410 :
G6P <-> bDG6P
Mlut_11410 :
G6P <-> F6P
Mlut_11410 :
bDG6P <-> F6P
Mlut_11410 :
G6P <-> bDG6P
Mlut_11410 :
G6P <-> F6P
Mlut_11410 :
bDG6P <-> F6P
Mlut_01060 :
G6P <-> G1P
Mlut_17370 :
F6P + ATP -> FDP + ADP
Mlut_05200 :
FDP -> F6P + PI
Mlut_02060 :
FDP <-> G3P + DHAP
Mlut_18420 :
FDP <-> G3P + DHAP
Mlut_11370 :
DHAP <-> G3P
Mlut_09530 :
G3P + PI + NAD <-> NADH + 13PDG
Mlut_11350 :
G3P + PI + NAD <-> NADH + 13PDG
Mlut_18410 :
G3P + PI + NADP <-> 13PDG + NADPH
Mlut_18410 :
G3P + PI + NAD <-> 13PDG + NADH
Mlut_11360 :
13PDG + ADP <-> 3PG + ATP
Mlut_03720 :
3PG <-> 2PG
Mlut_10190 :
3PG <-> 2PG
Mlut_04980 :
2PG <-> PEP
Mlut_11020 :
PEP + ADP -> PYR + ATP
Mlut_15310 :
PEP + ADP -> PYR + ATP
Mlut_06800 :
PYR + LIPO -> ADLIPO + CO2
Mlut_06810 :
PYR + LIPO -> ADLIPO + CO2
Mlut_09340 :
PYR + LIPO -> ADLIPO + CO2
Mlut_17800 :
PYR + LIPO -> ADLIPO + CO2
Mlut_17810 :
PYR + LIPO -> ADLIPO + CO2
Mlut_06820 :
COA + ADLIPO -> DLIPO + ACCOA
Mlut_17790 :
COA + ADLIPO -> DLIPO + ACCOA
Mlut_05640 :
DLIPO + NAD -> LIPO + NADH
#Citrate cycle (TCA Cycle)
Mlut_15490 :
ACCOA + OA -> COA + CIT
Mlut_13040 :
CIT <-> ICIT
Mlut_04530 :
ICIT + NADP -> NADPH + AKG + CO2
Mlut_07730 :
AKG + LIPO -> SDLIPO + CO2
Mlut_13330 :
SDLIPO + COA -> DLIPO + SUCCOA
Mlut_04270/Mlut_04280
:
ADP + PI + SUCCOA <-> ATP + SUCC + COA
Mlut_05170 :
FUM <-> MAL
Mlut_00950 :
MAL + NAD <-> NADH + OA
Mlut_00870 :
CIT -> AC + OA
Mlut_06890 :
CIT -> AC + OA
Mlut_19950 :
CIT -> AC + OA
# Pyruvate metabolism
Mlut_02430 :
ATP + AC + COA -> AMP + PPI + ACCOA
Mlut_02890 :
ATP + AC + COA -> AMP + PPI + ACCOA
Mlut_18230 :
ATP + AC + COA -> AMP + PPI + ACCOA
Mlut_20370 :
ATP + AC + COA -> AMP + PPI + ACCOA
Mlut_15880 :
ACCOA -> COA + AC
Mlut_01050 :
ACAL + NAD -> NADH + AC
Mlut_21440 :
ACAL + NADP -> NADPH + AC
Mlut_21510 :
LLAC + NAD <-> PYR + NADH
Mlut_05890 :
ACCOA + ATP + CO2 <-> MALCOA + ADP + PI
Mlut_02710 :
PYR + MK -> MKH2 + AC + CO2
Mlut_21430 :
ACAL + NADH <-> ETH + NAD
Mlut_22590 :
ACAL + NADH <-> ETH + NAD
Mlut_01770 :
AC + ATP -> ACETYLP + ADP
Mlut_01780 :
ACETYLP + COA -> ACCOA + PI
Mlut_13810 :
PYR + ATP + CO2 -> ADP + OA + PI
Mlut_03380 :
PEP + CO2 + GDP -> OA + GTP
#Pentose phosphate pathway
Mlut_11400 :
G6P + NADP -> D6PGL + NADPH
Mlut_11400 :
G6P + NAD -> D6PGL + NADH
Mlut_17870 :
G6P + NADP -> D6PGL + NADPH
Mlut_17870 :
G6P + NAD -> D6PGL + NADH
Mlut_09430 :
D6PGC + NADP -> NADPH + CO2 + RL5P
Mlut_10820 :
RL5P <-> X5P
Mlut_09810 :
RL5P <-> R5P
Mlut_01060 :
R1P <-> R5P
Mlut_06810 :
R5P + X5P <-> G3P + S7P
Mlut_06810 :
X5P + E4P <-> F6P + G3P
Mlut_17800 :
R5P + X5P <-> G3P + S7P
Mlut_17800 :
X5P + E4P <-> F6P + G3P
Mlut_11430 :
R5P + X5P <-> G3P + S7P
Mlut_11430 :
X5P + E4P <-> F6P + G3P
Mlut_11420 :
G3P + S7P <-> E4P + F6P
Mlut_11420 :
G3P + S7P <-> E4P + F6P
Mlut_05590 :
DR5P -> G3P + ACAL
Mlut_02040 :
G15L -> GLUC
Mlut_05630 :
UDPG + 2 NAD -> UDPDGLUC + 2 NADH
Mlut_08720 :
UDPG + 2 NAD -> UDPDGLUC + 2 NADH
Mlut_08980 :
UDPG + 2 NAD -> UDPDGLUC + 2 NADH
# Methane metabolism
Mlut_04620 :
FOR + NAD -> CO2 + NADH
Mlut_04320 :
FALD + NAD <-> FOR+ NADH + 2 H
Mlut_02220 :
METHANOL + 2 H2O2 -> FALD + O2
Mlut_04660 :
METHANOL + 2 H2O2 -> FALD + O2
Mlut_04640 :
FTHF + H2O -> FOR + THF
# Propanoate metabolism
Mlut_01780 :
PROPIONYLP + COA -> PROPIONYLCOA + PI
Mlut_01770 :
PROPANOATE + ATP -> PROPIONYLP + ADP
Mlut_14120 :
ATP + PROPANOATE + COA -> AMP + PPI + PROPIONYLCOA
Mlut_02440 :
MK + PROPIONYLCOA -> ACRCOA + MKH2
Mlut_02830 :
ACRCOA <-> HPCOA
Mlut_02840 :
ACRCOA <-> HPCOA
Mlut_19570 :
ACRCOA <-> HPCOA
Mlut_20200 :
ACRCOA <-> HPCOA
Mlut_20230 :
ACRCOA <-> HPCOA
Mlut_14160 :
PROPIONYLCOA + OA <-> 2MCIT + COA
Mlut_14150 :
2MICIT <-> PYR + SUCC
Mlut_14140 :
2MCIT <-> 2MACO
# Butanoate metabolism
Mlut_20240 :
AACCOA + NADPH <-> SHYDROXYBUTANOYL + NADP
Mlut_20300 :
AACCOA + NADPH <-> SHYDROXYBUTANOYL + NADP
Mlut_12970 :
AACCOA + NADPH <-> SHYDROXYBUTANOYL + NADP
Mlut_02830 :
CROTONOYLCOA <-> SHYDROXYBUTANOYL
Mlut_02840 :
CROTONOYLCOA <-> SHYDROXYBUTANOYL
Mlut_19570 :
CROTONOYLCOA <-> SHYDROXYBUTANOYL
Mlut_20200 :
CROTONOYLCOA <-> SHYDROXYBUTANOYL
Mlut_20230 :
CROTONOYLCOA <-> SHYDROXYBUTANOYL
Mlut_07590 :
BUTDIOL + NAD <-> ACTOIN + NADH
Mlut_07590 :
DIACTYL + NADH -> ACTOIN + NAD
# Inositol phosphate metabolism
Mlut_23300 :
G6P -> MI1P
Mlut_04390 :
MI1P -> MYOI + PI
Mlut_05950 :
MI1P -> MYOI + PI
# Glyoxylate shunt
Mlut_02080 :
ICIT -> GLX + SUCC
Mlut_02090 :
ACCOA + GLX -> COA + MAL
Mlut_10340 :
GLAL + NAD -> NADH + GLYCOLATE
Mlut_22180 :
GLYCOLATE + O2 -> GLX + H2O2
Mlut_02220 :
2 H2O2 -> O2
Mlut_04660 :
2 H2O2 -> O2
Mlut_01500 :
GLYCOLATE + NAD <-> GLX + NADH
Mlut_11340 :
2 SUPEROXIDE + 2 H -> O2 + H2O2
# ONE CARBON POOL BY FOLATE
Mlut_04690 :
METTHF + NADP <-> METHF + NADPH
Mlut_04690 :
METHF <-> FTHF
Mlut_07440 :
FAD + NADH <-> FADH2 + NAD
Mlut_17460 :
METTHF + dUMP <-> DHF + dTMP
Mlut_16430 :
ATP + FTHF -> ADP + PI + MTHF
# ENERGY METABOLISM
Mlut_11050 :
NADH + MK -> NAD + MKH2
Mlut_05010 :
NADH + FAD -> NAD + FADH2
Mlut_04820 :
SUCC + MK + 2 H <-> FUM + MKH2
Mlut_04830 :
SUCC + MK + 2 H <-> FUM + MKH2
Mlut_04840 :
SUCC + MK + 2 H <-> FUM + MKH2
Mlut_04850 :
SUCC + MK + 2 H <-> FUM + MKH2
Mlut_13210/Mlut_13220
bc1-aa3
:
:
MKH2 + 0.5 O2 -> MK + 2 H
MKH2 + 0.5 O2 -> MK + 6 H
Mlut_08120/Mlut_08130/Mlut_08140/Mlut_08150/Mlut_08160/Mlut_08170/M
lut_08180/Mlut_08190
:
ADP + PI + 4 H <-> ATP
Mlut_01180 :
PPI -> PI + PI
Mlut_01180 :
PPI -> PI + PI + H
Mlut_09420 :
nPOLYP + ATP <-> POLYP + ADP
Mlut_01640 :
ATP + PIout <-> ADP + PI + PIin
Mlut_16570 :
ATP + FECout <-> ADP + PI + FECin
Mlut_10030 :
2 FERO + NADP <-> 2 FERI + NADPH
Mlut_17680 :
2 FERO + NADP <-> 2 FERI + NADPH
Mlut_12120/Mlut_12210/Mlut_12220
FERI + 4 H_PO
:
2 FERO + 0.5 O2 + 4 H_PO -> 2
Mlut_21370 :
ATP + CUin -> ADP + PI + CUout
Mlut_18390 :
ATP + CUin -> ADP + PI + CUout
# Maximal P/O ratio can be set by changing the amount of protons consumed per
one ATP synthesis, here P/O ratio is 6/4 =1.5
# AMINO ACID METABOLISM
# Glutamate, Glutamine, Arginine, Proline
Mlut_13400 :
GLU + NH3 + ATP -> GLN + ADP + PI
Mlut_13430 :
GLU + NH3 + ATP -> GLN + ADP + PI
Mlut_11000/Mlut_11010
Mlut_19410 :
:
AKG + GLN + NADPH <-> NADP + 2 GLU
AKG + GLN + NADPH <-> NADP + 2 GLU
Mlut_11000/Mlut_11010
:
AKG + GLN + NADH <-> NAD + 2 GLU
Mlut_19410 :
AKG + GLN + NADH <-> NAD + 2 GLU
Mlut_00880 :
AKG + NH3 + NADH <-> GLU + NAD
Mlut_00880 :
AKG + NH3 + NADPH <-> GLU + NADP
Mlut_04440 :
AKG + NH3 + NADPH <-> GLU + NADP
Mlut_10140 :
GLU + ATP -> ADP + GLUP
Mlut_10150 :
GLUP + NADPH -> NADP + PI + GLUGSAL
Spontaneous :
GLUGSAL <-> P5C
Mlut_18050 :
P5C + NADPH + NADH <-> PRO + NADP + NAD
Mlut_01560 :
GLU + ACCOA -> COA + NAGLU
Mlut_14410 :
GLU + ACCOA -> COA + NAGLU
Mlut_14400 :
NAGLU + ATP -> ADP + NAGLUP
Mlut_14420 :
NAGLUP + NADPH -> NADP + PI + NAGLUS
Mlut_14390 :
NAGLUS + GLU -> AKG + NAORN
Mlut_14410 :
NAORN + GLU -> ORN + NAGLU
Mlut_12580/Mlut_12590
:
GLN + 2 ATP + CO2 -> GLU + CAP + 2 ADP + PI
Mlut_14340 :
CITR + ASP + ATP <-> AMP + PPI + ARGSUCC
Mlut_14330 :
ARGSUCC <-> FUM + ARG
r4.1.1.19
ARG -> AGMT + CO2
:
Mlut_19440 :
AGMT -> CBPTRSC + NH3
Mlut_04350 :
AGMT -> PTRSC + UREA
Mlut_03420/Mlut_03430/Mlut_03440
:
UREA -> CO2 + 2 NH3
Mlut_10360 :
GABA + AKG -> SUCCSAL + GLU
Mlut_05360 :
SUCCSAL + NADP -> SUCC + NADPH
Mlut_07850 :
SUCCSAL + NADP -> SUCC + NADPH
Mlut_08350 :
DGLUTAMATE <-> GLU
Mlut_04560 :
GLN -> GLU + NH3
Mlut_22150 :
GLN -> GLU + NH3
Mlut_19430 :
P5C + NAD -> NADH + GLU
Mlut_19430 :
GLUGSAL + NAD -> NADH + GLU
Mlut_14380 :
ORN + CAP <-> CITR + PI
Mlut_08010 :
ORN -> PTRSC + CO2
Mlut_01820 :
PTRSC + SAM -> SPRMD + 5MTA
Mlut_10560 :
URI + GTP <-> UMP + GDP
Mlut_10560 :
CYTD + GTP -> GDP + CMP
Mlut_10560 :
URI + ATP -> ADP + UMP
Mlut_19250 :
UREAC -> 2 NH3 + 2 CO2
Mlut_03150 :
ORN <-> PRO + NH3
# Valine, Isoleucine, Leucine (The branched chain amino acids)
Mlut_08530/Mlut_08540
:
PYR + PYR -> ACLAC + CO2
Mlut_21480 :
PYR + PYR -> ACLAC + CO2
Mlut_04360 :
PYR + PYR -> ACLAC + CO2
Mlut_08550 :
ACLAC + NADPH -> NADP + DHMVA
Mlut_08500 :
DHMVA -> OIVAL
Mlut_08600 :
OIVAL + GLU -> AKG + VAL
Mlut_05060 :
THR -> OBUT + NH3
Mlut_08530/Mlut_08540
:
PYR + OBUT -> ABUT + CO2
Mlut_21480 :
PYR + OBUT -> ABUT + CO2
Mlut_04360 :
PYR + OBUT -> ABUT + CO2
Mlut_08550 :
ABUT + NADPH -> NADP +
DIHYDROXYMETHYLPENTANOATE
Mlut_08500 :
DIHYDROXYMETHYLPENTANOATE ->
OXOMETHYLPENTANOATE
Mlut_08600 :
OXOMETHYLPENTANOATE + GLU -> AKG + ILE
Mlut_12300 :
ACCOA + OIVAL -> COA + IPPMAL
Mlut_08740/Mlut_08750
:
IPPMAL <-> CBHCAP
Mlut_08590 :
CBHCAP + NAD -> NADH + OICAP
Spontaneous :
OICAP -> MOP + CO2
Mlut_08600 :
MOP + GLU -> AKG + LEU
Mlut_06800 :
OXOMETHYLPENTANOATE + LIPO -> 2MBUTLIPO + CO2
Mlut_06820 :
COA + 2MBUTLIPO -> DLIPO + 2MBUTCOA
Mlut_17790 :
COA + 2MBUTLIPO -> DLIPO + 2MBUTCOA
Mlut_06870 :
2MBUTCOA + MK -> 2MBECOA + MKH2
Mlut_23170 :
2MBUTCOA + MK -> 2MBECOA + MKH2
Mlut_02440 :
2MBUTCOA + MK -> 2MBECOA + MKH2
Mlut_02830 :
2MBECOA -> HMBUTCOA
Mlut_02840 :
2MBECOA -> HMBUTCOA
Mlut_19570 :
2MBECOA -> HMBUTCOA
Mlut_20200 :
2MBECOA -> HMBUTCOA
Mlut_20230 :
2MBECOA -> HMBUTCOA
Mlut_12970 :
HMBUTCOA + NAD -> MAACCOA + NADH
Mlut_19540 :
MAACCOA + COA -> PROPIONYLCOA + ACCOA
Mlut_11720 :
MAACCOA + COA -> PROPIONYLCOA + ACCOA
Mlut_07600 :
MAACCOA + COA -> PROPIONYLCOA + ACCOA
Mlut_20220 :
MAACCOA + COA -> PROPIONYLCOA + ACCOA
Mlut_05890 :
PI
PROPIONYLCOA + CO2 + ATP -> SMMALONYLCOA + ADP +
Mlut_06800 :
MOP + LIPO -> 3MBUTLIPO + CO2
Mlut_06820 :
COA + 3MBUTLIPO -> DLIPO + 3MBUTCOA
Mlut_17790 :
COA + 3MBUTLIPO -> DLIPO + 3MBUTCOA
Mlut_02440 :
3MBUTCOA + MK -> 3MBECOA + MKH2
Mlut_06850 :
3MBECOA + ATP + CO2 -> MGLUTCOA + ADP + PI
Mlut_17880 :
MGLUTCOA -> HMGLUTCOA
Mlut_07610 :
ACTAC + SUCCOA <-> SUCC + AACCOA
Mlut_07620 :
ACTAC + SUCCOA <-> SUCC + AACCOA
Mlut_06800 :
OMVAL + LIPO -> IBUTLIPO + CO2
Mlut_06820 :
COA + IBUTLIPO -> DLIPO + IBUTCOA
Mlut_17790 :
COA + IBUTLIPO -> DLIPO + IBUTCOA
Mlut_02440 :
IBUTCOA + MK -> MACRCOA + MKH2
Mlut_02830 :
MACRCOA -> HIBUTCOA
Mlut_02840 :
MACRCOA -> HIBUTCOA
Mlut_19570 :
MACRCOA -> HIBUTCOA
Mlut_20200 :
MACRCOA -> HIBUTCOA
Mlut_20230 :
MACRCOA -> HIBUTCOA
r3.1.2.4
HIBUTCOA -> HIBUT + COA
:
Mlut_12970 :
HIBUT + NAD -> METHYLMALONATES + NADH
Mlut_02850 :
HIBUT + NAD -> METHYLMALONATES + NADH
Mlut_01370 :
HIBUT + NAD -> METHYLMALONATES + NADH
Mlut_01380 :
NADH + CO2
METHYLMALONATES + NAD + COA -> PROPIONYLCOA +
Mlut_02860 :
NADH + CO2
METHYLMALONATES + NAD + COA -> PROPIONYLCOA +
Mlut_10360 :
METHYLMALONATES + GLU <->
AMINOMETHYLPROPOATE + AKG
# Aspartate, Asparagine, Threonine, Lysine, Methionine
Mlut_08850 :
OA + GLU <-> ASP + AKG
Mlut_19000 :
ASP + ATP + GLN -> GLU + ASN + AMP + PPI
Mlut_02610 :
ASP + ATP -> ADP + BASP
Mlut_17490 :
BASP + NADPH -> NADP + PI + ASPSA
Mlut_08020 :
ASPSA + NADPH -> NADP + HSER
Mlut_08040 :
HSER + ATP -> ADP + PHSER
Mlut_08050 :
HSER + ATP -> ADP + PHSER
Mlut_08030 :
PHSER -> THR + PI
Mlut_07150 :
ASPSA + PYR -> DIHYDRODIPICOLINATE
Mlut_09540 :
ASPSA + PYR -> DIHYDRODIPICOLINATE
Mlut_07120 :
DIHYDRODIPICOLINATE + NADH + NADPH -> NAD + NADP
+ TETRAHYDRODIPICOLINATE
Mlut_15470 :
TETRAHYDRODIPICOLINATE + SUCCOA -> SAOPIM + COA
Mlut_15500 :
SAOPIM + GLU -> SDAPIM + AKG
Mlut_15460 :
SDAPIM -> DAPIM + SUCC
Mlut_07270 :
DAPIM <-> MDAPIM
Mlut_19060 :
NADPH
MDAPIM + NADP <-> TETRAHYDRODIPICOLINATE + NH3 +
Mlut_08010 :
MDAPIM -> LYS + CO2
Mlut_14780 :
HCYS + MTHPTGLU <-> THPTGLU + MET
Mlut_20790 :
HCYS + MTHPTGLU <-> THPTGLU + MET
Mlut_20790 :
HCYS + MTHF <-> THF + MET
Mlut_02350 :
OAHSER + H2S -> HCYS + AC
Mlut_06040 :
OAHSER + H2S -> HCYS + AC
Mlut_20820 :
OAHSER + H2S -> HCYS + AC
Mlut_20440 :
SAM + DNA -> SAH + DNA5MCY
Mlut_08850 :
CYS + AKG -> MCPYC + GLU
Mlut_07810 :
MCPYC + CYNIDE -> PYR + TCYNIDE
Mlut_10720 :
MCPYC + CYNIDE -> PYR + TCYNIDE
spontaneous :
ISUCC -> OA + NH3
Mlut_10360 :
bALA + AKG <-> MALONATES + GLU
Mlut_18570 :
ASN -> ASP + NH3
Mlut_22840 :
ASN -> ASP + NH3
Mlut_01000 :
THR -> GLY + ACAL
Mlut_07590 :
THR + NAD -> 2A3KB + NADH
spontaneous :
2A3KB -> AMINOACETONE + CO2
Mlut_02900 :
GLUTCOA + 2 NAD -> AACCOA + 2 NADH
Mlut_03070 :
GLUTCOA + 2 NAD -> AACCOA + 2 NADH
Mlut_19560 :
GLUTCOA + 2 NAD -> AACCOA + 2 NADH
Mlut_23170 :
GLUTCOA + 2 NAD -> AACCOA + 2 NADH
spontaneous :
OBUT + O2 + PI -> PROPIONYLP + CO2
# Alanine, Serine, Glycine, Cysteine
Mlut_19910 :
PYR + NH3 + NADH <-> ALA + NAD
Mlut_16720 :
ALA <-> DALA
Mlut_08790 :
2 DALA + ATP -> ALAALA + ADP + PI
Mlut_08560 :
3PG + NAD -> NADH + PHP
Mlut_04180 :
PHP + GLU -> AKG + 3PSER
Mlut_01160 :
3PSER -> PI + SER
Mlut_04680 :
THF + SER <-> GLY + METTHF
Mlut_22690 :
THF + SER <-> GLY + METTHF
Mlut_09440 :
SER + ACCOA -> COA + ASER
Mlut_09450 :
ASER + H2S -> CYS + AC
Mlut_06050 :
ACCOA + HSER <-> COA + OAHSER
Mlut_17600 :
SER + HCYS -> LLCT
Mlut_04510 :
SER + HCYS -> LLCT
Mlut_20810 :
LLCT -> CYS + NH3 + OBUT
Mlut_17590 :
LLCT -> CYS + NH3 + OBUT
Mlut_22690 :
LLCT -> CYS + NH3 + OBUT
Mlut_12520 :
MET + ATP -> PPI + PI + SAM
Mlut_05310 :
SAH -> HCYS + ADN
Mlut_13050 :
SAM -> SAH
Mlut_07070 :
SAM -> SAH
Mlut_02950 :
THF + SAP -> METTHF + NH3 + DHLIPOYLPROTEIN
Mlut_04680 :
THF + SER <-> GLY + METTHF
Mlut_02940 :
GLY + LIPOYLPROTEIN -> SAP + CO2
Mlut_05640 :
DHLIPOYLPROTEIN + NAD -> NADH + LIPOYLPROTEIN
Mlut_13320 :
DHLIPOYLPROTEIN + NAD -> NADH + LIPOYLPROTEIN
Mlut_02760 :
SER -> PYR + NH3
Mlut_05060 :
SER -> PYR + NH3
Mlut_20810 :
CYS -> H2S + PYR + NH3
Mlut_17590 :
CYS -> H2S + PYR + NH3
Mlut_22690 :
CYS -> H2S + PYR + NH3
r2.6.1.76
:
ASPSA + GLU -> DIAMINOBUNOATE + AKG
r2.3.1.178
+ COA
:
DIAMINOBUNOATE + ACCOA -> ACTYLDIAMINOBUNOATE
Mlut_02920 :
ACTYLDIAMINOBUNOATE -> ECTOINE
Mlut_07960 :
GLY + O2 -> GLX + NH3 + H2O2
Mlut_07960 :
# Histidine
DALA + O2 -> PYR + NH3 + H2O2
:
Mlut_10900 :
PRPP + ATP -> PPI + PRBATP
Mlut_10890 :
PRBATP -> PPI + PRBAMP
Mlut_10920 :
PRBAMP -> PRFP
Mlut_07390 :
PRFP -> PRLP
Mlut_07370 :
PRLP + GLN -> GLU + AICAR + DIMGP
Mlut_10910 :
PRLP + GLN -> GLU + AICAR + DIMGP
Mlut_07360 :
DIMGP -> IMACP
Mlut_07350 :
IMACP + GLU -> AKG + HISOLP
Mlut_20100 :
IMACP + GLU -> AKG + HISOLP
Mlut_15290 :
HISOLP -> PI + HISOL
Mlut_19310 :
HISOL + 2 NAD -> HIS + 2 NADH
Mlut_11630 :
HIS -> MHIS
Mlut_02290 :
HIS -> UROCANATE + NH3
Mlut_02260 :
UROCANATE -> ODHIMP
Mlut_02280 :
ODHIMP -> FORGLU
Mlut_02330 :
FORGLU -> GLU + FORMAMIDE
# Tryptophan
Mlut_10930 :
CHOR + GLN -> GLU + PYR + AN
Mlut_12100 :
AN + PRPP -> PPI + NPRAN
r5.3.1.24
NPRAN -> CPAD5P
:
Mlut_10960 :
CPAD5P -> CO2 + IGP
Mlut_10970/Mlut_10980
:
IGP + SER -> G3P + TRP
# Tyrosine, Phenylalanine
Mlut_14790 :
CHOR <-> PHEN
Mlut_01130 :
PHEN -> CO2 + PHPYR
Mlut_08850 :
PHPYR + GLU <-> AKG + PHE
Mlut_14060 :
PHEN + NAD -> 4HPP + CO2 + NADH
Mlut_08850 :
4HPP + GLU -> AKG + TYR
Mlut_07350 :
AKG + TYR <-> 4HPP + GLU
Mlut_20100 :
AKG + TYR <-> 4HPP + GLU
Mlut_07350 :
PHE + AKG <-> PHPYR + GLU
Mlut_20100 :
PHE + AKG <-> PHPYR + GLU
Mlut_20290 :
PHAC + NAD -> PAC + NADH
Mlut_01110 :
PHEACE -> PAC + NH3
Mlut_20330 :
PAC + ATP + CoA -> AMP + PPI + PHEACCCOA
#spontaneous
:
#r1.14.13.3
HPHENYLAC + NADH + O2 -> DIHYPREAC + NAD
:
PAC -> HPHENYLAC
#r1.13.11.15 :
DIHYPREAC + O2 -> CARMHMUCOSAL
Mlut_20000 :
CARMHMUCOSAL + NAD -> CARMHMUCO + NADH
#r5.3.3.10
:
CARMHMUCO -> CARHEPTENE
r4.1.1.68
:
CARHEPTENE <-> HYHEPTDIDIOATE + CO2
Mlut_20020 :
HYHEPTDIDIOATE -> DIHHENEDOATE
Mlut_20030 :
DIHHENEDOATE -> SUCCSAL
# Aminoacyl-tRNA biosynthesis
Mlut_14310 :
ATP + TYR + TRNA -> AMP + PPI + LTyrTRNA
Mlut_04760 :
ATP + TRP + TRNA -> AMP + PPI + TRPTRNA
Mlut_10670 :
ATP + THR + TRNA -> AMP + PPI + LTHETRNA
Mlut_12480 :
ATP + LEU + TRNA -> AMP + PPI + LLeuTRNA
Mlut_10050 :
ATP + ILE + TRNA -> AMP + PPI + LILEUTRNA
Mlut_01510 :
ATP + LYS + TRNA -> AMP + PPI + LLTRNA
Mlut_12720 :
ATP + ALA + TRNA -> AMP + PPI + LAlaTRNA
Mlut_09930 :
ATP + VAL + TRNA -> AMP + PPI + LValTRNA
Mlut_08580 :
ATP + MET + TRNA -> AMP + PPI + LMETTRNA
Mlut_01150 :
ATP + SER + TRNA -> AMP + PPI + LSERTRNA
Mlut_12790 :
ATP + ASP + TRNA -> AMP + PPI + ASPTRNA
Mlut_06090 :
ATP + GLY + TRNA -> AMP + PPI + GLYTRNA
Mlut_06960 :
ATP + PRO + TRNA -> AMP + PPI + LPROTRNA
Mlut_03790 :
ATP + CYS + TRNA -> AMP + PPI + LCYSTRNA
Mlut_11810 :
ATP + CYS + TRNA -> AMP + PPI + LCYSTRNA
Mlut_02670 :
ATP + GLU + TRNA -> AMP + PPI + LGLUTRNA
Mlut_08000 :
ATP + ARG + TRNA -> AMP + PPI + ALTRNA
Mlut_14470 :
ATP + PHE + TRNA -> AMP + PPI + LPheTRNA
Mlut_12810 :
ATP + GLU + TRNA -> AMP + PPI + HHTRNA
r6.1.1.24
ATP + GLU + TRNA -> AMP + PPI + GLUTRNAGLN
:
Mlut_05980/Mlut_05990/Mlut_06000
ADP + PI + GLUMITRNAGLN + GLU
r6.1.1.23
:
:
ATP + GLUTRNAGLN + GLN ->
ATP + ASP + TRNA -> AMP + PPI + ASPTRNAASN
Mlut_05980/Mlut_05990/Mlut_06000
PI + ASPGITRNAASN + GLU
: ATP + ASPTRNAASN + GLN -> ADP +
Mlut_10800 :
FTHF + LMETTRNA -> THF + FOFMET
Mlut_18760 :
SAM + TRNA -> SAH + METN7GTRNA
Mlut_09180 :
SAM + TRNA -> SAH + METN1GTRNA
# NUCLEOTIDE BIOSYNTHESIS
# Pyrimidines
Mlut_05480 :
R5P + ATP <-> PRPP + AMP
Mlut_12620 :
CAP + ASP -> CAASP + PI
Mlut_12610 :
CAASP <-> DOROA
Mlut_12260 :
DOROA + O2 <-> H2O2 + OROA
Mlut_12260 :
DOROA + MK <-> MKH2 + OROA
Mlut_01980 :
OROA + PRPP <-> PPI + OMP
Mlut_12570 :
OMP -> CO2 + UMP
Mlut_06760 :
ATP + UMP <-> ADP + UDP
Mlut_10080 :
UDP + ATP <-> UTP + ADP
Mlut_14180 :
UTP + GLN + ATP -> GLU + CTP + ADP + PI
Mlut_14180 :
ATP + UTP + NH3 -> ADP + PI + CTP
Mlut_10080 :
CDP + ATP <-> CTP + ADP
Mlut_10490 :
CDP + RTHIO -> DCDP + OTHIO
Mlut_10500 :
CDP + RTHIO -> DCDP + OTHIO
Mlut_10080 :
DCDP + ATP <-> DCTP + ADP
Mlut_04940 :
THY + DR1P <-> DT + PI
Mlut_02120 :
DT + ATP -> ADP + DTMP
Mlut_18990 :
DCTP -> DUTP + NH3
Mlut_13120 :
DUTP -> PPI + DUMP
Mlut_17460 :
METTHF + DUMP + FADH2 <-> THF + DTMP + FAD
Mlut_03690 :
DTMP + ATP <-> DTDP + ADP
Mlut_10080 :
DTDP + ATP <-> DTTP + ADP
Mlut_14050 :
CMP + ATP <-> ADP + CDP
Mlut_23380 :
OTHIO + NADPH -> RTHIO + NAD
Mlut_00630 :
OTHIO + NADPH -> RTHIO + NAD
Mlut_14050 :
DCMP + ATP <-> ADP + DCDP
Mlut_02120 :
DU + ATP -> DUMP + ADP
Mlut_04940 :
DU + PI <-> URA + DR1P
Mlut_03340 :
URA + PRPP -> UMP + PPI
Mlut_12630 :
URA + PRPP -> UMP + PPI
Mlut_03250 :
URA + R5P <-> PURI5P
# Purines
Mlut_18600 :
PRPP + GLN -> PPI + GLU + PRAM
Mlut_18510 :
PRAM + ATP + GLY <-> ADP + PI + GAR
Mlut_04480 :
GAR + FTHF -> THF + FGAR
Mlut_02500/Mlut_02510/Mlut_02520
ADP + PI + FGAM
:
FGAR + ATP + GLN -> GLU +
Mlut_18610 :
FGAM + ATP -> ADP + PI + AIR
Mlut_05240 :
AIR + CO2 + ATP -> CAIR + ADP + PI
Mlut_05230 :
AIR + CO2 + ATP -> CAIR + ADP + PI
Mlut_18500 :
CAIR + ATP + ASP <-> ADP + PI + SAICAR
Mlut_20390 :
SAICAR <-> FUM + AICAR
Mlut_04500 :
AICAR + FTHF <-> THF + PRFICA
Mlut_04500 :
PRFICA <-> IMP
Mlut_05920 :
ATP -> cAMP + PPI
Mlut_05920 :
GTP -> cGMP + PPI
r3.1.4.17
:
cAMP -> AMP
r3.1.4.17
:
cGMP -> GMP
Mlut_12550 :
DGMP + ATP <-> DGDP + ADP
Mlut_12550 :
GMP + DATP <-> GDP + DADP
Mlut_10080 :
DUDP + ATP <-> DUTP + ADP
Mlut_10080 :
IDP + ATP <-> ITP + ADP
Mlut_10490 :
UDP + RTHIO -> OTHIO + DUDP
Mlut_10500 :
UDP + RTHIO -> OTHIO + DUDP
Mlut_13880 :
AD + PRPP -> PPI + AMP
Mlut_13880 :
GN + PRPP -> PPI + GMP
Mlut_01220 :
HYXN + PRPP -> PPI + IMP
Mlut_01220 :
GN + PRPP -> PPI + GMP
Mlut_01220 :
AD + PRPP -> PPI + AMP
Mlut_01220 :
XAN + PRPP -> PPI + XMP
Mlut_05610 :
DIN + PI <-> HYXN + DR1P
Mlut_05610 :
DA + PI <-> AD + DR1P
Mlut_05610 :
DG + PI <-> GN + DR1P
Mlut_05610 :
HYXN + R1P <-> INS + PI
Mlut_05610 :
AD + R1P <-> PI + ADN
Mlut_05610 :
GN + R1P <-> PI + GSN
Mlut_05610 :
XAN + R1P <-> PI + XTSINE
Mlut_04960 :
ADN -> INS + NH3
Mlut_04960 :
ADN -> INS + NH3
Mlut_04960 :
ADN -> INS + NH3
Mlut_04960 :
ADN -> INS + NH3
Mlut_04960 :
ADN -> INS + NH3
Mlut_04960 :
DA -> DIN + NH3
Mlut_04960 :
DA -> DIN + NH3
Mlut_04960 :
DA -> DIN + NH3
Mlut_04960 :
DA -> DIN + NH3
Mlut_04960 :
DA -> DIN + NH3
Mlut_04930 :
CYTD -> URI + NH3
Mlut_06250 :
DGTP -> DG + H5P3O10
Mlut_12840 :
ATP + GTP -> ppGpp + AMP
Mlut_12840 :
ppGpp -> GDP + PPI
Mlut_14530 :
ADPRIB -> AMP + R5P
Mlut_16380 :
ADPRIB -> AMP + R5P
# ATP, dATP
Mlut_02210 :
IMP + GTP + ASP -> GDP + PI + ASUC
Mlut_20390 :
ASUC <-> FUM + AMP
Mlut_16960 :
ATP + AMP <-> ADP + ADP
Mlut_10490 :
ADP + RTHIO -> DADP + OTHIO
Mlut_10500 :
ADP + RTHIO -> DADP + OTHIO
Mlut_10080 :
DADP + ATP <-> DATP + ADP
# GTP, dGTP
Mlut_07740 :
IMP + NAD -> NADH + XMP
Mlut_16500 :
IMP + NAD -> NADH + XMP
Mlut_16510 :
IMP + NAD -> NADH + XMP
Mlut_16470 :
XMP + ATP + GLN -> GLU + AMP + PPI + GMP
Mlut_12550 :
GMP + ATP <-> GDP + ADP
Mlut_10080 :
GDP + ATP <-> GTP + ADP
Mlut_10490 :
GDP + RTHIO -> DGDP + OTHIO
Mlut_10500 :
GDP + RTHIO -> DGDP + OTHIO
Mlut_10080 :
DGDP + ATP <-> DGTP + ADP
# LIPIDS BIOSYNTHESIS
# Fatty acids biosynthesis (Path I)
Mlut_09320 :
MALCOA + ACP -> MALACP + COA
Mlut_09310 :
ACCOA + ACP -> ACACP + COA
Mlut_13230 :
ACCOA + ACP -> ACACP + COA
Mlut_09310, Mlut_13230, Mlut_09290, Mlut_11580, Mlut_11730
:
ACACP + 4 MALACP + 8 NADPH -> 8 NADP + C100ACP + 4 CO2 + 4 ACP
Mlut_09310, Mlut_13230, Mlut_09290, Mlut_11580, Mlut_11730
:
ACACP + 5 MALACP + 10 NADPH -> 10 NADP + C120ACP + 5 CO2 + 5 ACP
Mlut_09310, Mlut_13230, Mlut_09290, Mlut_11580, Mlut_11730
:
ACACP + 6 MALACP + 12 NADPH -> 12 NADP + C140ACP + 6 CO2 + 6 ACP
Mlut_09310, Mlut_13230, Mlut_09290, Mlut_11580, Mlut_11730
:
ACACP + 6 MALACP + 11 NADPH -> 11 NADP + C141ACP + 6 CO2 + 6 ACP
Mlut_09310, Mlut_13230, Mlut_09290, Mlut_11580, Mlut_11730
:
ACACP + 7 MALACP + 14 NADPH -> 14 NADP + C160ACP + 7 CO2 + 7 ACP
Mlut_09310, Mlut_13230, Mlut_09290, Mlut_11580, Mlut_11730
:
ACACP + 7 MALACP + 13 NADPH -> 13 NADP + C161ACP + 7 CO2 + 7 ACP
Mlut_09310, Mlut_13230, Mlut_09290, Mlut_11580, Mlut_11730
:
ACACP + 8 MALACP + 16 NADPH -> 16 NADP + C180ACP + 8 CO2 + 8 ACP
Mlut_09310, Mlut_13230, Mlut_09290, Mlut_11580, Mlut_11730
:
ACACP + 8 MALACP + 15 NADPH -> 15 NADP + C181ACP + 8 CO2 + 8 ACP
Mlut_22420 :
C181ACP + NADH + O2 <-> C182ACP + NAD + 2 H2O
Mlut_09320 :
PROPIONYLCOA + ACP -> PROPIONYLACP + COA
Mlut_09310, Mlut_13230, Mlut_09290, Mlut_11580, Mlut_11730
:
PROPIONYLACP + 6 MALACP + 12 NADPH -> 12 NADP + C150ACP + 6
CO2 + 6 ACP
Mlut_09310, Mlut_13230, Mlut_09290, Mlut_11580, Mlut_11730
:
PROPIONYLACP + 7 MALACP + 14 NADPH -> 14 NADP + C170ACP + 7
CO2 + 7 ACP
Mlut_09310, Mlut_13230, Mlut_09290, Mlut_11580, Mlut_11730
:
ACACP + 2 MALACP + 4 NADPH -> 4 NADP + C060ACP + 2 CO2 + 2 ACP
Mlut_09300 :
C060ACP + COA <-> C060COA + ACP
Mlut_09310, Mlut_13230, Mlut_09290, Mlut_11580, Mlut_11730
:
ACACP + 6.5 MALACP + 13 NADPH -> 13 NADP + C150ACP + 6.5 CO2 + 6.5
ACP
# Fatty acids biosynthesis (Path II)
Mlut_07600 :
2 ACCOA <-> COA + AACCOA
Mlut_11720 :
2 ACCOA <-> COA + AACCOA
Mlut_19540 :
2 ACCOA <-> COA + AACCOA
Mlut_20220 :
2 ACCOA <-> COA + AACCOA
Mlut_11700, Mlut_02830, Mlut_02840, Mlut_19570, Mlut_20200, Mlut_20230,
Mlut_02900, Mlut_03070, Mlut_19560, Mlut_23170
:
AACCOA + 2
NADH <-> 2 NAD + C040COA
Mlut_07600, Mlut_11720, Mlut_19540, Mlut_20220, Mlut_11700, Mlut_02830,
Mlut_02840, Mlut_19570, Mlut_20200, Mlut_20230
:
AACCOA +
ACCOA + 4 NADH <-> 4 NAD + C060COA + COA
Mlut_11700, Mlut_02830, Mlut_02840, Mlut_19570, Mlut_20200, Mlut_20230
:
AACCOA + 2 ACCOA + 6 NADH <-> 6 NAD + C080COA + 2 COA
Mlut_11700, Mlut_02830, Mlut_02840, Mlut_19570, Mlut_20200, Mlut_20230
:
AACCOA + 3 ACCOA + 8 NADH <-> 8 NAD + C100COA + 3 COA
Mlut_11700, Mlut_02830, Mlut_02840, Mlut_19570, Mlut_20200, Mlut_20230
:
AACCOA + 4 ACCOA + 10 NADH <-> 10 NAD + C120COA + 4 COA
Mlut_11700, Mlut_02830, Mlut_02840, Mlut_19570, Mlut_20200, Mlut_20230
:
AACCOA + 5 ACCOA + 12 NADH <-> 12 NAD + C140COA + 5 COA
Mlut_11700, Mlut_02830, Mlut_02840, Mlut_19570, Mlut_20200, Mlut_20230
:
AACCOA + 6 ACCOA + 14 NADH <-> 14 NAD + C160COA + 6 COA
Mlut_22810 :
C60 + COA + ATP <-> C060COA + PPI + AMP
Mlut_13790 :
C60 + COA + ATP <-> C060COA + PPI + AMP
Mlut_05330 :
C60 + COA + ATP <-> C060COA + PPI + AMP
Mlut_22810 :
C80 + COA + ATP <-> C080COA + PPI + AMP
Mlut_13790 :
C80 + COA + ATP <-> C080COA + PPI + AMP
Mlut_05330 :
C80 + COA + ATP <-> C080COA + PPI + AMP
Mlut_22810 :
C100 + COA + ATP <-> C100COA + PPI + AMP
Mlut_13790 :
C100 + COA + ATP <-> C100COA + PPI + AMP
Mlut_05330 :
C100 + COA + ATP <-> C100COA + PPI + AMP
Mlut_22810 :
C120 + COA + ATP <-> C120COA + PPI + AMP
Mlut_13790 :
C120 + COA + ATP <-> C120COA + PPI + AMP
Mlut_05330 :
C120 + COA + ATP <-> C120COA + PPI + AMP
Mlut_22810 :
C140 + COA + ATP <-> C140COA + PPI + AMP
Mlut_13790 :
C140 + COA + ATP <-> C140COA + PPI + AMP
Mlut_05330 :
C140 + COA + ATP <-> C140COA + PPI + AMP
Mlut_22810 :
C150 + COA + ATP <-> C150COA + PPI + AMP
Mlut_13790 :
C150 + COA + ATP <-> C150COA + PPI + AMP
Mlut_05330 :
C150 + COA + ATP <-> C150COA + PPI + AMP
Mlut_22810 :
C160 + COA + ATP <-> C160COA + PPI + AMP
Mlut_13790 :
C160 + COA + ATP <-> C160COA + PPI + AMP
Mlut_05330 :
C160 + COA + ATP <-> C160COA + PPI + AMP
Mlut_22810 :
C161 + COA + ATP <-> C161COA + PPI + AMP
Mlut_13790 :
C161 + COA + ATP <-> C161COA + PPI + AMP
Mlut_05330 :
C161 + COA + ATP <-> C161COA + PPI + AMP
Mlut_22810 :
C170 + COA + ATP <-> C170COA + PPI + AMP
Mlut_13790 :
C170 + COA + ATP <-> C170COA + PPI + AMP
Mlut_05330 :
C170 + COA + ATP <-> C170COA + PPI + AMP
Mlut_22810 :
C180 + COA + ATP <-> C180COA + PPI + AMP
Mlut_13790 :
C180 + COA + ATP <-> C180COA + PPI + AMP
Mlut_05330 :
C180 + COA + ATP <-> C180COA + PPI + AMP
Mlut_22810 :
C181 + COA + ATP <-> C181COA + PPI + AMP
Mlut_13790 :
C181 + COA + ATP <-> C181COA + PPI + AMP
Mlut_05330 :
C181 + COA + ATP <-> C181COA + PPI + AMP
Mlut_22810 :
C182 + COA + ATP <-> C182COA + PPI + AMP
Mlut_13790 :
C182 + COA + ATP <-> C182COA + PPI + AMP
Mlut_05330 :
C182 + COA + ATP <-> C182COA + PPI + AMP
Mlut_20060 :
RFERRE + NAD <-> OFERRE + NADH
# Phospholipids biosynthesis
# Phosphatidylethanolamine, Phosphatidylglycerol, Cardiolipin
PHOSPHOLIPID1
:
GL3P + 0.094 C140ACP + 0.294 C150ACP + 0.262
C160ACP + 0.293 C170ACP + 0.057 C181ACP -> AGL3P + ACP
PHOSPHOLIPID2
:
DHAP + 0.094 C140ACP + 0.294 C150ACP + 0.262
C160ACP + 0.293 C170ACP + 0.057 C181ACP -> ADHAP + ACP
PHOSPHOLIPID3
:
ADHAP + NADPH -> AGL3P + NADP
Mlut_13770 :
AGL3P + 0.094 C140ACP + 0.294 C150ACP + 0.262
C160ACP + 0.293 C170ACP + 0.057 C181ACP -> PA + ACP
Mlut_08770 :
AGL3P + 0.094 C140ACP + 0.294 C150ACP + 0.262
C160ACP + 0.293 C170ACP + 0.057 C181ACP -> PA + ACP
Mlut_11290 :
AGL3P + 0.094 C140ACP + 0.294 C150ACP + 0.262
C160ACP + 0.293 C170ACP + 0.057 C181ACP -> PA + ACP
Mlut_06780 :
PA + CTP <-> CDPDG + PPI
r2.7.8.8
:
CDPDG + SER <-> CMP + PS
r4.1.1.65
:
PS -> PE + CO2
Mlut_08780 :
DHAP + NADH <-> GL3P + NAD
Mlut_23030 :
DHAP + QH2 <-> GL3P + Q
Mlut_01040 :
GLYCEROCHO -> GL3P+ ALCOHOL
Mlut_01400 :
GLYCEROCHO -> GL3P+ ALCOHOL
Mlut_01720 :
GLYCEROCHO -> GL3P+ ALCOHOL
Mlut_06680 :
CDPDG + GL3P <-> CMP + PGP
Mlut_10690 :
CDPDG + GL3P <-> CMP + PGP
Mlut_07180 :
CDPDG + GL3P <-> CMP + PGP
r3.1.3.27
PGP -> PI + PG
:
Mlut_21690 :
CDPDG + PG -> CMP + CL
r2.7.7.39
:
GL3P + CTP -> PPI + CDPGL
r2.7.8.12
:
12 CDPGL -> 12 CMP + POLYGP
# Polyprenoids
# Polyprenoids
Mlut_13030 :
PYR + G3P -> DX5P + CO2
Mlut_06920 :
DX5P + NADPH -> MDE4P + NADP
Mlut_03780 :
MDE4P + CTP -> CDPMDE + PPI
Mlut_05400 :
CDPMDE + ATP -> 2PCDPMDE + ADP
Mlut_03780 :
2PCDPMDE -> MDECPP + CMP
Mlut_06940 :
MDECPP + NADH -> NAD + HMB4PP
Mlut_16300 :
HMB4PP + NADH -> NAD + IPP
Mlut_16300 :
HMB4PP + NADH -> NAD + DMPP
Mlut_21260 :
IPP <-> DMPP
Mlut_11440 :
DMPP + IPP -> GPP + PPI
Mlut_13720 :
GPP + IPP -> FPP + PPI
Mlut_05130 :
GPP + IPP -> FPP + PPI
Mlut_17720 :
FPP + IPP -> HEPPP + PPI
Mlut_12280 :
FPP + 8 IPP -> 8 PPI + DECAPPP
Mlut_21240 :
FPP + IPP -> GGPP + PPI
Mlut_11440 :
GGPP + IPP -> PPPP + PPI
Mlut_11440 :
GGPP + IPP -> PPPP + PPI
r2.5.1.33
PPPP + IPP -> HPPP + PPI
:
Mlut_17720 :
HPPP + IPP -> HEPPP + PPI
Mlut_17720 :
HEPPP + IPP -> OPP + PPI
r2.5.1.84
GPP + 7 IPP -> NPP + 7 PPI
:
#Synthesis of long-chain alkene
Mlut_13230, Mlut_13240, Mlut_13250
:
NADPH -> C170COA + COA + 2 NADP + CO2
C150COA + MALCOA + 2
Mlut_13230, Mlut_13240, Mlut_13250
:
NADPH -> C190COA + COA + 2 NADP + CO2
C170COA + MALCOA + 2
Mlut_13230, Mlut_13240, Mlut_13250
:
NADPH -> C210COA + COA + 2 NADP + CO2
C190COA + MALCOA + 2
Mlut_13230, Mlut_13240, Mlut_13250
:
NADPH -> C230COA + COA + 2 NADP + CO2
C210COA + MALCOA + 2
Mlut_13230, Mlut_13240, Mlut_13250
:
NADPH -> C250COA + COA + 2 NADP + CO2
C230COA + MALCOA + 2
Mlut_13230, Mlut_13240, Mlut_13250
:
NADPH -> C270COA + COA + 2 NADP + CO2
C250COA + MALCOA + 2
Mlut_13230, Mlut_13240, Mlut_13250
:
NADPH -> C290COA + COA + 2 NADP + CO2
C270COA + MALCOA + 2
# COFACTORS BIOSYNTHESIS
# The shikimate pathway
Mlut_13760 :
E4P + PEP -> PI + 3DDAH7P
Mlut_13760 :
E4P + PEP -> PI + 3DDAH7P
Mlut_12660 :
3DDAH7P -> DQT + PI
Mlut_21280 :
DQT -> DHSK
Mlut_04980 :
DQT -> DHSK
Mlut_12690 :
DHSK + NADPH -> SME + NADP
Mlut_12670 :
SME + ATP -> ADP + SME3P
Mlut_07690 :
SME3P + PEP -> 3PSME + PI
Mlut_12680 :
3PSME -> PI + CHOR
# Nicotinamide nucleotides (NAD+, NADP+)
r1.4.3.16
:
ASP + FUM -> ISUCC + SUCC
r1.4.3.16
:
ASP + O2 -> ISUCC + H2O2
Mlut_15680 :
ISUCC + DHAP -> PI + QA
Mlut_15690 :
QA + PRPP -> NACN + CO2 + PPI
Mlut_08310 :
NAM <-> NAC + NH3
Mlut_08320 :
NAC + PRPP -> NACN + PPI
Mlut_10170 :
NACN + ATP -> PPI + NAAD
Mlut_01960 :
NAAD + ATP + NH3 -> NAD + AMP + PPI
Mlut_05610 :
NAC + R1P -> PI + NACD
Mlut_05610 :
NAM + R1P -> PI + NAMD
Mlut_00750 :
NAMD + ATP -> NAMN + ADP
Mlut_00760 :
NAMD + ATP -> NAMN + ADP
Mlut_10170 :
NAMN + ATP -> PPI + NAD
Mlut_14220 :
NAD + ATP -> NADP + ADP
r3.2.2.5
:
NAD -> ADPRIB + NAM
rNADPH
: NADH + NADP + H -> NADPH + NAD
# Riboflavin (vitamin B2), FMN and FAD
Mlut_10870 :
GTP -> D6RP5P + FOR + PPI
Mlut_10850 :
D6RP5P -> A6RP5P + NH3
Mlut_10850 :
A6RP5P + NADPH -> A6RP5P2 + NADP
Mlut_10880 :
DB4P + A6RP -> D8RL + PI
r3.1.3.-
A6RP5P2 -> A6RP + PI
:
Mlut_10870 :
RL5P -> DB4P + FOR
Mlut_10860 :
2 D8RL -> RIBFLAV + A6RP
Mlut_07060 :
RIBFLAV + ATP -> FMN + ADP
Mlut_07060 :
FMN + ATP -> FAD + PPI
# Coenzyme-A
Mlut_13440 :
OIVAL + METTHF -> AKP + THF
r1.1.1.169
AKP + NADPH -> NADP + PANT
:
Mlut_20270 :
ASP -> CO2 + bALA
Mlut_01440 :
PANT + bALA + ATP -> AMP + PPI + PNTO
Mlut_16790 :
PNTO + ATP -> ADP + 4PPNTO
Mlut_12530 :
4PPNTO + CTP + CYS -> CMP + PPI + 4PPNCYS
Mlut_12530 :
4PPNCYS -> CO2 + 4PPNTE
Mlut_08860 :
4PPNTE + ATP -> PPI + DPCOA
Mlut_11180 :
DPCOA + ATP -> ADP + COA
Mlut_11170 :
DPCOA + ATP -> ADP + COA
Mlut_16740 :
COA -> PAP + ACP
r3.1.4.14
ACP -> 4PPNTE
:
# Folate
Mlut_01250 :
GTP -> FOR + AHTD
Mlut_19690 :
AHTD -> DHP + 3 PI
Mlut_14320 :
AHTD -> DHP + PPI + PI
Mlut_01270 :
DHP -> AHHMP + GLAL
Mlut_01280 :
AHHMP + ATP -> AMP + AHHMD
Mlut_00740 :
CHOR + GLN -> ADCHOR + GLU
Mlut_06300 :
CHOR + GLN -> ADCHOR + GLU
Mlut_18900 :
ADCHOR -> PYR + PABA
Mlut_01260 :
PABA + AHHMD -> PPI + DHPT
Mlut_14860 :
PABA + AHHMD -> PPI + DHPT
Mlut_01260 :
PABA + AHHMP -> DHPT
Mlut_14860 :
PABA + AHHMP -> DHPT
Mlut_10060 :
DHPT + ATP + GLU -> ADP + PI + DHF
Mlut_17470 :
DHF + NADPH -> NADP + THF
Mlut_10060 :
THF + ATP + GLU <-> ADP + PI + THFG
# Menaquinone
Mlut_21330 :
CHOR <-> ICHOR
Mlut_17740 :
ICHOR + AKG -> SHCHC + PYR + CO2
Mlut_17760 :
SHCHC -> OSB
Mlut_17900 :
OSB + ATP + COA -> AMP + PPI + OSBCOA
Mlut_17880 :
OSBCOA -> DHN + COA
Mlut_17910 :
DHN + NPP -> PPI + CO2 + DMK
Mlut_22070 :
DMK + SAM -> MKH2 + SAH
# Antranilate
Mlut_10930 :
CHOR + GLN -> GLU + PYR + AN
Mlut_12110 :
AN + PRPP -> PPI + NPRAN
Mlut_10960 :
CPAD5P -> CO2 + IGP
#Biotin
Mlut_05890 :
CBCCP + ACCOA <-> BCCP + MALCOA
Mlut_05670 :
ATP + BCCP + CO2 -> ADP + PI + CBCCP
Mlut_06860 :
ATP + BCCP + CO2 -> ADP + PI + CBCCP
Mlut_02190 :
DTB + 2 SAM + S -> BT + 2 MET + 2 DA
Mlut_05900 :
BT + ATP + AACOACOL -> ACOACOL + PPI + AMP
#Porphyrin, Heme
Mlut_15240 :
LGLUTRNA + NADPH -> GLU1SAL + TRNA + NADP
Mlut_15130 :
GLU1SAL -> AMIEVUL
Mlut_15140 :
2 AMIEVUL -> PPBG
Mlut_15190 :
4 PPBG + H2O -> HMTB + 4 NH3
Mlut_15180 :
HMTB -> UPGIII
Mlut_15230 :
UPGIII -> CPGIII + 4 CO2
Mlut_12400 :
CPGIII + 2 SAM -> PPGIX + 2 CO2 + 2 MET + 2 DA
Mlut_15220 :
PPGIX + 3 O2 -> PPRIX + 3 H2O
Mlut_19080 :
PPGIX + 3 O2 -> PPRIX + 3 H2O
Mlut_15200 :
PPRIX -> PHEME
Mlut_11440 :
PHEME -> HEME_O
Mlut_11450 :
HEME_O -> HEME_A
Mlut_10020 :
SAM + UPGIII -> SAH + PRECOR
Mlut_10020 :
PRECOR + NAD -> SHCR + NADH
Mlut_10020 :
SHCR -> SIHM
#Thiamine
Mlut_07900 :
AIR -> AHM
Mlut_07930 :
AHM + ATP -> AHMP + ADP
Mlut_07930 :
AHMP + ATP -> AHMPP + ADP
Mlut_03020 :
AHMP + ATP -> AHMPP + ADP
r2.7.1.50
THZ + ATP -> THZP + ADP
:
Mlut_07950 :
THZP + AHMPP -> THMP + PPI
Mlut_08710 :
THMP + ATP -> THDP + ADP + PI
Mlut_08380 :
ATP + THDP -> THMP + ADP + PI
#Glutathione
Mlut_13800 :
NADPH + OGT -> NADP + 2 RGT
# SUBSTRATES UTILISATION
# CARBON SOURCES
# C3 compounds
# Glycerol
Mlut_23050 :
GL + ATP -> GL3P + ADP
Mlut_23030 :
GL3P + MK -> DHAP + MKH2
Mlut_01050 :
T3 + NAD -> NADH + DGLYCERATE
# C6 compounds
# Fructose
Mlut_02060 :
F1P -> DHAP + T3
Mlut_18420 :
F1P -> DHAP + T3
Mlut_00940 :
FRU + ATP -> F6P + ADP
Mlut_18060 :
FRU <-> GLC
# Mannose
Mlut_04860 :
MAN6P <-> F6P
Mlut_05210 :
MAN6P <-> F6P
Mlut_03540 :
MAN6P <-> MAN1P
Mlut_05600 :
MAN6P <-> MAN1P
Mlut_04860 :
GTP + MAN1P -> PPI + GDPMAN
Mlut_04860 :
GDP + MAN1P <-> PI + GDPMAN
# Galactose
Mlut_05730 :
UDPG <-> UDPGAL
Mlut_15870 :
UDPG + GAL1P <-> G1P + UDPGAL
Mlut_08870 :
G1P + UTP <-> UDPG + PPI
# Lactate
Mlut_10340 :
LACTAL + NAD -> LLAC + NADH
Mlut_04620 :
LAC + NAD <-> PYR + NADH
Mlut_08790 :
DALA + LAC + ATP -> ALALAC + ADP + PI
# Disaccharides
# maltose
Mlut_01920 :
MLT -> 2 GLC
Mlut_01920 :
SUC -> GLC + FRU
# lactose
r3.2.1.23
:
LACTOSE -> GLAC + GLC
# trehalose
Mlut_17860 :
TRE6P -> TRE + PI
Mlut_21740 :
TRE -> 2 GLC
#Amino sugar and nucleotide sugar metabolism
Mlut_03260 :
ATP + G1P <-> PPI + ADPGLC
Mlut_11680 :
ATP + G1P <-> PPI + ADPGLC
Mlut_06290 :
GA6P <-> F6P + NH3
Mlut_08960 :
UDPMANNAC + 2 NAD <-> UDPMANNACA + 2 NADH
Mlut_16830 :
GA6P <-> GA1P
Mlut_09080 :
UDPNAG <-> UDPMANNAG
Mlut_08520 :
NAGM6P <-> GA6P + AC
Mlut_16770 :
F6P + GLN -> GLU + GA6P
Mlut_01060 :
GA6P <-> GA1P
Mlut_05450 :
ACCOA + GA1P -> NAGA1P + COA
Mlut_05450 :
UTP + NAGA1P <-> UDPNAG + PPI
#Peptidoglycan Biosynthesis
Mlut_08760 :
UDPNAG + PEP -> UDPNACVG + PI
Mlut_17500 :
UDPNACVG + NADPH -> UDPNAM + NADP
Mlut_13590 :
ATP + UDPNAM + ALA -> ADP + PI + UDPMURNACLALA
Mlut_13620 :
ATP + UDPMURNACLALA + DGLUTAMATE -> ADP + PI +
UDPMURNACLALAGLU
Mlut_13650 :
ATP + UDPMURNACLALAGLU -> ADP + PI +
UDPMURNACLALAGLUDP
Mlut_13640 :
ATP + UDPMURNACLALAGLUDP -> ADP + PI +
UDPMURNACLALAGLUDPAA
Mlut_13630 :
MURACUNDECAP
UDPMURNACLALAGLUDPAA + UDECAPP -> UMP +
Mlut_13600 :
MURACUNDECAP + UDPNAG -> UDP + GLCNACMURPP
Mlut_00770, Mlut_13660, Mlut_16800, Mlut_01190
> PEPTIDOGLYCAN + DALA
:
Spontaneous :
PEPTIDOGLYCAN -> UDECAPPP
Mlut_08790 :
ATP + 2 DALA -> ADP + PI + ALAALA
Mlut_11800 :
UDECAPPP -> UDECAPP + PI
# SULPHATE METABOLISM
Mlut_09980 :
SLF + ATP -> PPI + APS
Mlut_09990 :
APS + ATP -> ADP + PAPS
Mlut_09970 :
APS + RTHIO -> OTHIO + H2SO3 + AMP
Mlut_09960 :
H2SO3 + 6 FERO -> H2S + 6 FERI
r3.1.3.7
PAP -> PI + AMP
:
Mlut_21270 :
AMP + H2SO3 + OTHIO <-> APS + RTHIO
# NITROGEN METABOLISM
Mlut_09960 :
NO2 + 6 FERO -> NH3 + 6 FERI
GLCNACMURPP -
Mlut_05180 :
CO2 + H2O -> H + HCO3
Mlut_03510 :
2 NO + 2 O2 + NADH -> 2 NO3 + NAD
# CAROTENOID BIOSYNTHESIS
Mlut_21240 :
FPP + IPP -> GGPP + PPI
Mlut_21230 :
2 GGPP -> PPI + PPTPPI
Mlut_21230 :
PPTPPI -> PHYTOENE + PPI
Mlut_21220 :
PHYTOENE -> BCAROTENE
Mlut_21220 :
PHYTOENE -> LYCOPENE
Mlut_21210 :
LYCOPENE -> NNFVXANTHIN
Mlut_21210 :
NNFVXANTHIN -> FVXANTHIN
Mlut_21190/Mlut_21200
:
FVXANTHIN -> SXANTHIN
rCrtX :
SXANTHIN -> SXANTHINMGS
rCrtX :
SXANTHINMGS -> SXANTHINDGS
# TRANSPORT REACTIONS
# FREE DIFFUSSION
CO2_in_out
:
CO2xt <-> CO2
FOR_in_out
: FORxt <-> FOR
NH3_in_out
:
NH3xt <-> NH3
NO3_in_out
:
NO3xt <-> NO3
O2_in_out
:
O2xt <-> O2
GLYCOLATE_in_out :
GLYCOLATExt <-> GLYCOLATE
# FACILITATED DIFFUSSION
ACAL_in_out :
ACALxt <-> ACAL
AN_out
AN <-> ANxt
:
CITR_in_out :
CITR <-> CITRxt
GL_in_out
GLxt <-> GL
:
GLYN_in_out :
GLYNxt <-> GLYN
GN_in_out
GNxt <-> GN
:
HYXN_in_out :
HYXNxt <-> HYXN
NAC_in_out
:
NACxt <-> NAC
PAC_out
:
PAC <-> PACxt
T3_in_out
:
T3xt <-> T3
UREA_in_out :
UREAxt <-> UREA
XAN_in_out
XANxt <-> XAN
:
# AMINO ACID TRANSPORT
ALA_in:
ALAxt + ATP -> ALA + ADP + PI
ARG_in
:
ARGxt + ATP -> ARG + ADP + PI
ASN_in
:
ASNxt + ATP -> ASN + ADP + PI
ASP_in1
:
ASPxt + ATP -> ASP + ADP + PI
DGLUTAMATE_in
:
DAPIM_in
DAPIMxt + ATP -> DAPIM + ADP + PI
:
DGLUTAMATExt + ATP -> DGLUTAMATE + ADP + PI
CYS_in :
CYSxt + ATP -> CYS + ADP + PI
GLN_in
:
GLNxt + ATP -> GLN + ADP + PI
GLU_in
:
GLUxt + ATP -> GLU + ADP + PI
HIS_in1
:
HISxt + ATP -> HIS + ADP + PI
ILE_in1
:
ILExt + ATP -> ILE + ADP + PI
LEU_in1
:
LEUxt + ATP -> LEU + ADP + PI
LYS_in1
:
LYSxt + ATP -> LYS + ADP + PI
MET_in
:
METxt + ATP -> MET + ADP + PI
MLT_in
:
MLTxt + ATP -> MLT + ADP + PI
ORN_in
:
ORNxt + ATP -> ORN + ADP + PI
PRO_in1
:
PROxt + ATP -> PRO + ADP + PI
SLF_in :
SLFxt + ATP -> SLF + ADP + PI
THR_in1
:
THRxt + ATP -> THR + ADP + PI
VAL_in1
:
VALxt + ATP -> VAL + ADP + PI
# Carbon sources transport
LACTOSE_in :
GLC_in :
LACTOSExt + ATP -> LACTOSE + ADP + PI
GLCxt + H -> GLC
# Phosphate transport
PI_in :
PIxt + ATP -> 2 PI + ADP
# PROTON-LINKED ACTIVE TRANSPORT
AC_in_out
:
ACxt + H <-> AC
AD_in_out
:
ADxt + H <-> AD
ADN_in_out
:
ADNxt + H <-> ADN
ASP_in2
:
ASPxt + H -> ASP
ASP_in3
:
ASPxt + 2 H -> ASP
ASP_in4
:
ASPxt + 3 H -> ASP
CIT_in_out
:
CITxt + 3 H <-> CIT
CYTD_in_out :
CYTDxt + H <-> CYTD
CYTS_in_out :
CYTSxt + H <-> CYTS
DA_in_out
DAxt + H <-> DA
:
DALA_in_out :
DALAxt + H <-> DALA
DC_in_out
:
DCxt + H <-> DC
DG_in_out
:
DGxt + H <-> DG
DIN_in_out
:
DINxt + H <-> DIN
DT_in_out
:
DTxt + H <-> DT
DU_in_out
:
DUxt + H <-> DU
ETH_in_out
:
ETHxt + H <-> ETH
AKG_in_out
: AKGxt + H <-> AKG
FUM_in1
:
FUMxt + 2 H -> FUM
FUM_in2
:
FUMxt + 3 H -> FUM
GABA_in_out :
GABAxt + H <-> GABA
TRP_in_out
:
TRPxt + H <-> TRP
TYR_in_out
:
TYRxt + H <-> TYR
URA_in_out
:
URAxt + H <-> URA
URI_in_out
:
URIxt + H <-> URI
VAL_in2
:
VALxt + H -> VAL
VAL_out
:
VAL -> VALxt + H
GLU_out
:
GLU -> GLUxt + H
GLY_in_out
:
GLYxt + H <-> GLY
GSN_in_out
:
GSNxt + H <-> GSN
HIS_in2
:
HISxt + H -> HIS
HIS_out
:
HIS -> HISxt + H
ILE_out
:
ILE -> ILExt + H
ILE_in2
:
ILExt + H -> ILE
INS_in_out
:
INSxt + H <-> INS
LAC_in_out
:
LACxt + H <-> LAC
LEU_in2
:
LEUxt + H -> LEU
LEU_out
:
LEU -> LEUxt + H
LLAC_in_out :
LLACxt + H <-> LLAC
LYS_in2
:
LYSxt + H -> LYS
LYS_out
:
LYS -> LYSxt + H
MAL_in1
:
MALxt + 2 H -> MAL
MAL_in2
:
MALxt + 3 H -> MAL
PHE_in_out
:
PHExt + H <-> PHE
PI_in_out
:
PIxt + H <-> PI
PRO_in2
:
PROxt + H -> PRO
PRO_out
:
PRO -> PROxt + H
PROPANOATE_in_out
PYR_in_out
:
:
PROPANOATExt + H <-> PROPANOATE
PYRxt + H <-> PYR
SER_in1
:
SERxt + H -> SER
SER_out
:
SER -> SERxt + H
SUCC_in1
:
SUCCxt + 2 H -> SUCC
SUCC_in2
:
SUCCxt + 3 H -> SUCC
SUCC_out
:
SUCC -> SUCCxt + H
THR_in2
:
THRxt + H -> THR
THR_out
:
THR -> THRxt + H
# Antiporters
CIT_in_SUCC_out
: CITxt + SUCC -> CIT + SUCCxt
FUM_in_SUCC_out
:
FUMxt + SUCC <-> FUM + SUCCxt
GL3P_in_PI_out
:
GL3Pxt + PI -> GL3P + PIxt
#######################################################
#################
# PTS:PEP transport system
FRU_in1
:
FRUxt + PEP -> PYR + F6P
FRU_in2
:
FRUxt + PEP -> PYR + F1P
MAN_in
:
MANxt + PEP -> PYR + MAN6P
TRE_in: TRExt + PEP -> TRE6P + PYR
#Transport reaction
METHANOL_in_out :
H2SO3_in_out :
METHANOLxt <-> METHANOL
H2SO3xt <-> H2SO3
#Biomass Equation (Directly taken from S. coelicolor, Borodina et al, Genome
Research, 2005)
#Lipid synthesis
PHOSLIP: 1.089 PE + 0.250 PG + 0.052 CL -> PHOSPHOLIPID
TRI_GLYOLS: 1.244 GL3P + 0.050 C140ACP + 1.677 C150ACP + 0.421 C160ACP +
1.570 C170ACP + 0.014 C181ACP -> TAG + 3.732 ACP + 1.244 PI
#Small molecules synthesis
SMALL_MOL: 0.188 NAD + 0.168 NADP + 0.163 COA + 0.012 ACP + 0.146 MK +
0.281 THF + 0.274 FMN + 0.159 FAD -> SMALL MOLECULES
#Nucleotide synthesis
DNA_syn: 0.448 DATP + 1.169 DCTP + 0.448 DTTP + 1.169 DGTP + 4.4 ATP -> 4.4
ADP + 4.4 PI + 3.236 PPI + DNA
RNA_syn: 0.600 ATP + 0.826 GTP + 1.031 CTP + 0.662 UTP + 1.25 ATP -> 1.25
ADP + 1.25 PI + RNA + 3.119 PPI
#Protein synthesis
PROTEIN_syn: 1.350 ALA + 0.352 ARG + 0.394 ASN + 0.391 ASP + 0.165 CYS +
0.382 GLN + 0.379 GLU + 2.015 GLY + 0.131 HIS + 0.477 ILE + 0.742 LEU + 0.499
LYS + 0.221 MET + 0.238 PHE + 0.422 PRO + 0.459 SER + 0.465 THR + 0.059 TRP
+ 0.159 TYR + 0.797 VAL + 40.0 ATP -> 40.0 ADP + 40.0 PI + PROTEIN
#Carbohydrate synthesis
CARBO: 1.897 UDPNAG + 3.794 UDPGAL -> 5.691 UDP + CARBOHYDRATE
# Cell wall synthesis
PEP_GLYCAN: 1.007 UDPNAM + 1.197 UDPNAG + 1.900 ALAALA + 0.950 ALA +
1.140 MDAPIM + 1.014 DGLUTAMATE + 0.973 GLY + 5.026 ATP ->
PEPTIDOGLYCAN + 0.950 DALAxt + 1.197 UDP + 1.007 UMP + 5.026 ADP + 5.026
PI
TEICH_ACID: 0.518 POLYGP + 0.129 LYS + 0.129 UDPNAG + 0.129 ATP -> TEICH
+ 0.129 UDP + 0.129 ADP + 0.129 PI
#Biomass production
Growth: 0.412 PROTEIN + 0.167 RNA + 0.036 DNA + 0.027 PHOSPHOLIPID +
0.018 TAG + 0.03 SMALL MOLECULES + 0.110 PEPTIDOGLYCAN + 0.044
CARBOHYDRATE + 0.066 TEICH + 47 ATP -> BIOMASS + 47 ADP + 47 PI
#ATP maintanace
ATP_main
: ATP -> ADP + PI
-CONSTRAINTS
AC_in_out [-100000, 0]
ADN_in_out [-100000, 0]
AD_in_out [-100000, 0]
AKG_in_out [-100000, 0]
ALA_in [0, 0]
AN_out [0, 100000]
ARG_in [0, 0]
ASN_in [0, 0]
ASP_in3 [0, 0]
ASP_in4 [0, 0]
ASP_in1 [0, 0]
ASP_in2 [0, 0]
ATP_main [3.8, 3.8]
CITR_in_out [0, 100000]
CIT_in_out [-100000, 0]
CIT_in_SUCC_out [0, 0]
CO2_in_out [-100000, 0]
CYS_in [0, 0]
CYTD_in_out [-100000, 0]
CYTS_in_out [-100000, 0]
DALA_in_out [0, 0]
DAPIM_in [0, 0]
DA_in_out [-100000, 0]
DC_in_out [-100000, 0]
DGLUTAMATE_in [0, 0]
DG_in_out [-100000, 0]
DIN_in_out [-100000, 0]
DT_in_out [-100000, 0]
DU_in_out [-100000, 0]
ETH_in_out [-100000, 0]
FOR_in_out [-100000, 0]
FRU_in2 [0, 0]
FRU_in1 [1, 1]
FUM_in1 [0, 0]
FUM_in2 [0, 0]
FUM_in_SUCC_out [0, 0]
GABA_in_out [-100000, 0]
GL3P_in_PI_out [0, 0]
GLC_in [0, 0]
GLN_in [0, 0]
GLU_out [0, 100000]
GLU_in [0, 0]
GL_in_out [-100000, 0]
GLYCOLATE_in_out [-100000, 0]
GLYN_in_out [-100000, 0]
GLY_in_out [-100000, 0]
GN_in_out [-100000, 0]
GSN_in_out [-100000, 0]
HIS_out [0, 100000]
HIS_in1 [0, 0]
HIS_in2 [0, 0]
HYXN_in_out [-100000, 0]
ILE_out [0, 100000]
ILE_in1 [0, 0]
ILE_in2 [0, 0]
INS_in_out [-100000, 0]
#KDG_in_out [-100000, 0]
LACTOSE_in [0, 0]
LAC_in_out [-100000, 0]
LEU_out [0, 100000]
LEU_in1 [0, 0]
LEU_in2 [0, 0]
LLAC_in_out [-100000, 0]
LYS_out [0, 100000]
LYS_in1 [0, 0]
LYS_in2 [0, 0]
MAL_in1 [0, 0]
MAL_in2 [0, 0]
MAN_in [0, 0]
MET_in [0, 0]
MLT_in [0, 0]
NAC_in_out [-100000, 0]
NH3_in_out [-100000, 100000]
NO3_in_out [-100000, 0]
O2_in_out [0, 100000]
ORN_in [0, 0]
PAC_out [-100000, 0]
PHE_in_out [-100000, 0]
PI_in [0, 100000]
PI_in_out [-100000, 100000]
PRO_out [0, 100000]
PROPANOATE_in_out [-100000, 0]
PRO_in1 [0, 0]
PRO_in2 [0, 0]
PYR_in_out [-100000, 0]
SER_out [0, 100000]
SER_in1 [0, 0]
SLF_in [0, 100000]
ACAL_in_out [-100000, 0]
SUCC_out [0, 100000]
SUCC_in1 [0, 0]
SUCC_in2 [0, 0]
T3_in_out [-100000, 0]
THR_out [0, 100000]
THR_in1 [0, 0]
THR_in2 [0, 0]
TRE_in [0, 0]
TRP_in_out [-100000, 0]
TYR_in_out [-100000, 0]
URA_in_out [-100000, 0]
UREA_in_out [-100000, 0]
URI_in_out [-100000, 0]
VAL_out [0, 100000]
VAL_in1 [0, 0]
VAL_in2 [0, 0]
XAN_in_out [-100000, 0]
Mlut_03150 [0, 0]
-EXTERNAL METABOLITES
BIOMASS
ACALxt
ACxt
ADNxt
ADxt
AKGxt
ALAxt
ANxt
ARGxt
ASNxt
ASPxt
CITRxt
CITxt
CO2xt
CYSxt
CYTDxt
CYTSxt
DALAxt
DAPIMxt
DAxt
DCxt
DGLUTAMATExt
DGxt
DINxt
DTxt
DUxt
ETHxt
FORxt
FRUxt
FUMxt
GABAxt
GL3Pxt
GLCxt
GLNxt
GLUxt
GLxt
GLYCOLATExt
GLYNxt
GLYxt
GNxt
GSNxt
HISxt
HYXNxt
ILExt
INSxt
LACTOSExt
LACxt
LEUxt
LLACxt
LYSxt
MALxt
MANxt
METxt
MLTxt
NACxt
NH3xt
NO3xt
O2xt
ORNxt
PACxt
PHExt
PIxt
PROxt
PROPANOATExt
PYRxt
OTHIO
SERxt
SLFxt
SUCCxt
T3xt
THRxt
TRExt
TRPxt
TYRxt
URAxt
UREAxt
URIxt
VALxt
XANxt
-MAXIMIZE
Growth