PHRM 5103
Medical Immunology
Course Syllabus
Fall 2012
Course Instructors
Dr. Christopher Farrell (Course Coordinator)
Assistant Professor/Pharmaceutical Sciences
Office: RM219
Phone: (864) 938-3834
E-mail: [email protected]
Office hours: W 2:30-3:30
F 1-2
Dr. Amy Messersmith
Assistant Professor/Pharmaceutical Sciences
Office: RM206
Phone: (864) 938-3874
E-mail: [email protected]
Dr. Eddie Grace
Associate Professor/Pharmacy Practice
Office: RM305
Phone: (864) 938-3856
E-mail: [email protected]
Questions about course material should be submitted to the course instructor responsible for teaching the
related material. If the question is not resolved or the student has questions about course administration
the student should contact the course coordinator in person or via phone or e-mail. If the question/issue is
not resolved, the student should contact the Department Chair of the course coordinator finally, the
Associate Dean for Academic Affairs.
Course Description
Medical immunology will be an introductory course that presents the basic elements of the immune
system, the means through which the mechanisms of immunity act in a wide range of clinical
conditions, including protection against infectious agents, rejection of tumors, transplantation of
tissues and organs, autoimmune and other immunopathologic conditions, and allergy. (Fall P1
year; three lecture hours per week)
Course Objectives
The objectives of this course are:
1) To develop an understanding about the two types of immune responses - the innate and the
adaptive
2) To identify all the major cellular components and molecules involved in the different types of
immune responses
3) To develop an understanding about the mechanisms which are clinically important for
defending against infectious agents and other diseases
4) To identify the inappropriate responses of the immune system including immunodeficiency
diseases, hypersensitivities, and autoimmune diseases
5) To identify some of the pharmaceutical agents/products that target the immune system
including immunosuppressive drugs, vaccines, and monoclonal antibody therapies
Course Learning Outcomes (ACPE Appendix B Outcomes)
Immunology
Methods of Assessment
Quizzes
Written assignments/ homework
Short-answer exams
Multiple choice exams
Participation
Active Learning Techniques
Problem based learning
Clicker-based activities
Online and written quizzes
PC Twelve Competencies met by this Course
Evidence Based Decisions in the Practice of Pharmacy
Problem Prevention and Solving
Class Meeting Times
M, W, F 8:30-9:20 AM
(Lecture)
Room 104 Center for Pharmacy Education
Textbook
Required: The Immune System; Third Edition; Peter Parham
PowerPoint slides, case studies, and articles will be available on the Moodle website.
Recommended: Immunobiology: The Immune System In Health and Disease; Sixth Edition;
Charles A. Janeway, Paul Travers, Mark Walport; Mark J Schomchick
Kuby Immunology; Sixth Edition; Kindt, Goldsby, Osborne
Attendance and Participation
Students are expected to attend and actively participate in all class sessions; attendance will be
monitored regularly throughout the semester (including unannounced quizzes). Attendance for
classes with a guest speaker is considered mandatory. Excused absences will be granted by the
course coordinator on an individual basis, and only if an appropriate excuse (such as student
illness or injury with doctor’s note, or death of immediate family member) is provided by the
student within 1 week of the missed class, assignment, quiz, or exam. Once attendance or quiz
grades are posted, students have one (1) week to contest the grade; after that time period the
posted grade is final. There will be no make-ups for any unexcused absences resulting in a
missed graded assignment, quiz, or exam. Absence from more than 20% of lectures may result
in a 1 letter grade reduction to be imposed at the end of the semester upon the student’s final
earned grade in the course.
Classroom Etiquette
Professionalism is reflected in one's behavior in class. In this class the following are expected as
characteristics of professional behavior:

Reading assignments should be completed before class.




Students are expected to be ready to begin class at the scheduled time and remain in the
classroom until class is dismissed.
Avoid any and all behavior that does not allow others to hear and learn. Side conversations
should be kept to a minimum during lectures.
All cell phones and other electronic devices / noise-making devices should be turned OFF
during class.
Student participation during lecture is encouraged and instructors will gladly address student
questions during class.
Special Accommodations
Any student in this course who has a disability that may prevent him/her from fully demonstrating
his/her abilities should contact the instructor personally as soon as possible to discuss
accommodations necessary to ensure full participation and facilitate his/her educational
opportunities
Honor Code
The School of Pharmacy supports and enforces the College's Honor System. Pharmacy students
are expected to read, understand, and abide by the tenets of the PC Blue Book. Quizzes, tests,
examinations, projects, and papers to be graded should be accompanied by the pledge “On my
honor, I pledge that I have neither given nor received any unacknowledged aid on
this assignment” followed by the student’s signature. Unacknowledged aid includes aid that is
not allowed by the instructor. In some courses, students will be expected to work in small
groups to conduct experiments or other projects. When authorized by the instructor, these
activities are not Honor Code violations. However, the interpretation of data and the reporting of
results and conclusions are, unless stated otherwise by the instructor, individual responsibilities.
Assignments and Grading Policy
Basis for course grade:
Grading Scale:
Quizzes (Weekly)/Case Studies/Attendance
Exam I
Exam II
Exam III
Final Exam
93
90
87
83
80
77
70
60
59
- 100%
- 92
– 89
– 86
– 82
– 79
– 76
– 69
or below
20%
20%
20%
20%
20%
A
AB+
B
BC+
C
D
F
(Grading scale approved by faculty)
The course coordinator reserves the right to make adjustments to the grading scale as necessary in
recording the final grade.
These policies will be followed as closely as possible throughout the semester; however, the course coordinator
reserves the right to adjust policies if needed during the semester. Any adjustment(s) will be provided in writing to
the students prior to implementation.
Topical Outline
Medical Immunology
Fall 2012
PHRM 5103
Date
M
08/20
W
08/22
F
M
W
F
M
W
F
M
W
F
M
W
F
M
W
F
M
W
F
M
W
F
M
W
F
M
W
F
M
W
F
M
W
F
M
W
F
M
W
F
M
W
F
Th
08/24
08/27
08/29
08/31
09/03
09/05
09/07
09/10
09/12
09/14
09/17
09/19
09/21
09/24
09/26
09/28
10/01
10/03
10/05
10/08
10/10
10/12
10/15
10/17
10/19
10/22
10/24
10/26
10/29
10/31
11/02
11/05
11/07
11/09
11/12
11/14
11/16
11/19
11/21
11/23
11/26
12/28
12/30
12/06
Topic
Overview of the course
Introduction to the Immune System (Ch1)
Concepts of the Immune System (Ch1)
(Cells & Lymphoid Tissues)
Innate Immunity – Front Line of Defense (Ch2)
Complement (Ch2)
Innate Immunity-Receptors (Ch2)
Antibodies – Structure & Function (Ch3 & 4)
Antibodies – Immunoglobulin Genes (Ch3 & 4)
Antibodies – Structure & Function (Ch3 & 4)
T Exam I
T-Cell Receptors (Ch3 & 5)
MHC molecules – Gene Rearrangement (Ch5)
MHC molecules
Development of B-Cells (Ch6) (Case Study)
Development of T-Cells (Ch7)
Lymphoid Diseases
T-Cell Mediated Immunity (Ch8) (Case Study)
T-Cell Mediated Immunity (Ch8)
T-Cell Mediated Immunity (Ch8)
Exam II
Humoral Immune (B-cell) Response (Ch9)
Humoral Immune (B-cell) Response (Case Study)
FALL BREAK
Response of Adaptive Immunity (Ch10)
Inherited Immunodeficiency Diseases (Ch11)
Inherited Immunodeficiency Diseases (Ch11)
HIV/AIDS (Ch11)
Allergy (Hypersensivity I) (Ch12)
Allergy cont/Hypersensivity II-IV (Case Study)
Hypersensivity cont. (Ch12)
Autoimmunity (Ch13)
Autoimmunity (Ch13)
Autoimmunity (Ch13)
Exam III
Cancer (Ch16)
Manipulation of the Immune System (Case Study)
Manipulation of the Immune System-Autoimmune
Manipulation of the Immune System - Cancer
Transplant Rejection (Ch15)
Immunosuppressive Agents (Case Study)
Vaccinations (Ch14)
THANKSGIVING BREAK
THANKSGIVING BREAK
Vaccinations
Vaccinations
Vaccinations/ Review
Exam IV
9AM-12PM
Instructor
Farrell
Farrell
Farrell
Farrell
Farrell
Farrell
Farrell
Farrell
Farrell
Farrell
Farrell
Farrell
Farrell
Farrell
Farrell
Farrell
Messersmith
Messersmith
Messersmith
Farrell
Farrell
Farrell
Farrell
Farrell
Farrell
Grace
Farrell
Farrell
Farrell
Messersmith
Messersmith
Messersmith
Farrell
Farrell
Farrell
Farrell
Farrell
Farrell
Farrell
Farrell
Farrell
Messersmith
Farrell
This topical outline will be followed as closely as possible throughout the semester; however, the instructor(s)
reserve the right to adjust the course schedule as he/she deems necessary.