• The liver is the largest internal and most metabolically complex organ in humans. • The liver performs more than 500 different functions for example: fighting off infection, neutralizing toxins, manufacturing proteins and hormones, controlling blood sugar and helping to clot the blood. • medical terms related to the liver often start in 'hepato'- or 'hepatic'. • At any given time, your liver contains about 10% of the blood which your body contains and it pumps about 1.4 liters through per minute. • (fun fact) For the Greeks, the liver was considered the seat of the emotions. They practised something called 'hepatoscopy' which involved sacrificing oxen or goats and examining their livers to determine whether their military campaigns would succeed or fail. The Greeks viewed the liver as being the organ in closest contact with divinity. • The liver is the only organ that can regenerate itself thus making it possible for one person to donate part of their liver to another person. When a portion of the liver is transplanted, the donor's liver will regenerate back to its original size while the transplanted portion will grow to the appropriate size for the recipient. • The liver is positioned just under the ribs. • The liver is dark reddish-brown in colour and made up of two sections (lobes), the right being much larger than the left. It has two blood supplies: one from the heart and the other, full of nutrients, from the intestines (the portal vein). Right Left • Two-thirds of the liver is made up of liver cells; the rest is made up of tubes known as bile ducts. . The pancreas is a carrot shaped gland which lies just below your stomach . The larger end of the pancreas is on the right tucking into the gut. . The tail end in on the left, touching your spleen. . The pancreas is made from a substance called exoane tissue. .The pancreas is a glandular organ that secretes digestive enzymes and hormones. . It lies beneath the stomach and is connected to the small intestine at the duodenum. • it makes and secretes bile to help your body absorb fats and fat-soluble vitamins (A, D, E and K) • It metabolizes and stores carbohydrates, fats, sugars, vitamins (and other nutrients obtained from the foods we eat) for energy and brain function. • It breaks down harmful chemicals (bilirubin and ammonia) produced by the body and keeps the body regulated and healthy. • It manufactures proteins to help maintain blood purity and proper flow. • It breaks down hormones, detoxifies water and removes drugs, alcohol and environmental toxins • And it filters waste products from your blood. • Assimilating and storing fat-soluble vitamins • Creating bile • Filtering blood • Metabolizing fats, proteins, and carbohydrates • Metabolizing hormones, internally-produced wastes, and foreign chemicals • Producing urea (a primary waste product, flushed from the body in urine) • Purifying and clearing waste products, toxins, and drugs • Regulating and secreting substances important to maintaining body functions and health • Storing important nutrients (such as glycogen glucose), vitamins, and minerals • Synthesizing blood proteins Bile Production • One of the functions of the liver as it relates to the digestive system is that it produces bile. Bile is necessary for the breakdown of fats. The liver makes bile and stores it in the gallbladder. When a person consumes fatty foods, the gallbladder will release bile into the stomach in order to help the acids of the stomach breakdown the fat. Nutrients and Toxins • The liver also processes nutrients and toxins. When a person eats, the stomach and small intestine digests the food (or liquids or medications and vitamins). The broken-down substances are absorbed by the intestine walls and travel to the liver. The liver then breaks them down further. Molecules that are nutritional are transformed in such a way that become the most beneficial for what the body needs at the time. Toxins are broken down into molecules that are the least harmful possible. Glucose • The liver also receives and produces glucose. Most of the glucose the liver receives is produced during the digestive process in the small intestine. The enzymes in the small intestine break down the molecules in carbohydrates and sugar, producing glucose molecules, which then travel from the small intestine to the liver. The liver stores it as glycogen. When you need energy, the liver will transform the glycogen back into glucose, which is then sent into the bloodstream. Toxin Metabolism The liver also can play a role in the digestive system by the way that it filters out toxins. Some things that the digestive system absorbs can build up in the blood and poison the tissues of the digestive tract or other organs. The liver is one of the main areas in which toxins and other things are broken down (a process called metabolism). This is another way in which the liver interacts with the digestive system---by metabolizing some of the nutrients and chemicals that it absorbs. For example, the liver plays a major role in the way the digestive system handles alcohol, by helping process and eliminate the chemical. Blood Sugar Another function of the liver is how it works with the digestive system to modulate the amount of sugar in the blood. When the digestive system absorbs excess sugar in the form of glucose, the liver may take some of this energy and convert it into a highly compact carbohydrate called glycogen. This allows the liver to store excess sugar when it has been consumed. During periods in which the digestive system is not absorbing sugar, the glycogen can be converted back into glucose and used to keep blood sugar levels high--even during times of starvation. The pancreas is a cream-coloured gland, lying just underneath the stomach. The pancreas makes a fluid called pancreatic juice which contains many enzymes and flows along the pancreatic duct that goes from the pancreas to the duodenum. These enzymes include amylase, trypsin, and lipase Amylase, one of the enzymes produced by the pancreas breaks down starch to maltose. Another is lipase which breaks down neutral fats to fatty acids and glycerol. Another is trypsin, which is a protease and breaks down proteins to polypeptides. Pancreatic juice contains sodium hydrogencarbonate which neutralises the hydrochloric acid in the chime coming from the stomach The more acid the chime has, the more pancreatic juice is released
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