1 Your Hormone Blueprint Are you here to find answers to your unwanted symptoms? Perhaps you’re having difficulty with energy levels through your day, or you drive your loved ones crazy with moodiness? Maybe you dread your periods due to pain or heaviness, or experience unwanted skin break outs and stubborn mid section weight gain? The underlying culprit to your health challenges may be a hormone imbalance and you’ve come to the right place to find out more! 2 2 ~ Hormones 101 Hormones have the significant job in your body of delivering important chemical messages to your tissues and organs. Ultimately this controls functions such as your metabolism, hunger, cravings, sexual function, physiology, reproduction, moods and energy levels as well as skin and hair health. Your hormones are produced from a group of cells called endocrine glands, these include the hypothalamus, pituitary, pineal and thymus glands in your brain, your adrenal and thyroid glands, your pancreas and your ovaries (in men, ovaries are replaced with testes). It’s heartbreaking to learn that young women are going through high school and into their early adulthood, without gaining a sound knowledge and understanding of their hormones and precious reproductive cycle. I was no different! To be honest, throughout my teens I didn’t know when and how ovulation took place. I was equipped with the basics - knowing I inconveniently had my period once a month but because I was on the oral contraceptive pill, I wouldn’t fall pregnant. It helped to keep my skin under control and gave me freedom and convenience for you-know-what. I was oblivious to the fact that my ovaries had shut down and I wasn’t ovulating, let alone getting an explanation from my GP about potential short and long term side effects of taking the “innocent” daily pill. 3 It wasn’t until my naturopathy studies that I began to truly understand the intricate happenings of a woman’s cycle, both naturally and on synthetic hormones. It fascinated me and once I was supporting patients in clinic, I developed a passion to pass this knowledge on to women like yourself. Educating you about options other than synthetic hormones is of vital importance to me. There are natural ways to balance your hormones and overcome hormone driven symptoms along with natural contraceptive alternatives which empower you with knowledge of your natural cycle rhythms and are free from dangerous side effects. More information coming up in later chapters. In this chapter, I will pass on the valuable information for you to learn the intricacies of your reproductive cycle and the other hormones which ultimately affect their function. Unfortunately, my experience in clinic repeatedly shows a scenario similar to Lena’s* story. Lena has never really understood her cycle, but is well aware of her painful periods and suffers from moodiness, breast tenderness and cravings before her period. Lena visits her GP and is explained the solution to her health challenge is in the oral contraceptive pill. She is not however given an explanation of any risks involved in taking the pill. A few years go by and Lena and her partner Jake decide they would like to prepare for having a baby. Lena discontinues taking the pill but is shocked when 4 months later, she still hasn’t experienced her period. Skin breakouts occur around Lena’s chin and jawline, her moodiness is heightened and she has put on a few very unwelcome kilos. Lena looks into how the oral contraceptive pill works and is surprised by what she discovers. It turns out all this time taking the pill, she has not been ovulating and her periods were merely a ‘withdrawal bleed.’ Lena is also shocked by the generous amount of data indicating the negative effects the pill has placed on her body, long and short term. From deficiencies in vital nutrients, disruption to her gut bacteria balance and an increased risk of developing the side effects of long term use, including depression, blood clots and breast cancer. Lena is devastated. She has been misinformed. *Names have been changed to protect the privacy of my patients. 4 Note: When taking the oral contraceptive pill, you are not experiencing a natural period, but instead a forced withdrawal bleed from stopping the active hormone pills each month. The good news is that with dedication to nourish your body and mind, such an imbalance in hormones can be addressed. A regular cycle can return and hormonal imbalance symptoms such as mood swings, cravings and fluid retention can be overcome when you take control of your health. Whether you have a history of synthetic hormone use or not, throughout this book my aim is to teach you how to move forward the natural way. The topic of hormones involves quite a complex discussion, including your brain, ovaries, pancreas, thyroid and adrenal glands. To clearly understand the role of hormones in your body, let me take you back to that awkward talk you may have been given at school or by your parents. Here I have a more detailed chat about your monthly menstrual cycle. Fig. 1: The endocrine system 5 Your menstrual cycle summary Your complex reproductive cycle is a brain driven event with your master gland, called the hypothalamus, calling the shots. To ensure a cycle runs its natural course, communication and feedback loops occur between your hypothalamus and the pituitary gland in your brain, with your ovaries. This interaction controls the different stages of your menstrual cycle. Your hypothalamus triggers the development of an immature egg by releasing gonadotropin – releasing hormone (GrRH). GrRH functions to stimulate your pituitary gland (also in the brain), to release two powerful hormones into your bloodstream - follicle stimulating hormone (FSH) and luteinising hormone (LH). In response to this production of the FSH and LH from your pituitary gland, hormones progesterone and oestrogen are released from your ovaries at differing amounts throughout the cycle. Fig. 2: Communication between your brain and your ovaries 6 These female hormones perform powerful actions within your body such as triggering the development for future reproduction (at puberty), initiating the formation of a new life, nurturing a baby through pregnancy and breastfeeding and eventually slowing the reproductive process as you reach menopause and beyond. Reproductive hormones also allow adaptive response to stress, exertion and strong emotions, such as love. Your menstrual cycle begins at puberty, with an initial surge of oestrogen from your ovaries, which was stimulated by the pituitary gland in your brain. This oestrogen promotes the growth of your breasts, the development of your reproductive system and the shape of your body. Cycles are often irregular for the first year after your initial period, as the body perfects its intricate communication of hormones and events occurring throughout your menstrual cycle. Once egg production and follicle development is running on schedule, your menstrual cycle should regulate into a monthly occurrence. Although great variation can occur from cycle to cycle and from one woman to the next, a textbook cycle will last for 28 days. Day one is the first day of your period (not including spotting) and the last day of your cycle is the day before menstrual bleeding begins once again. Ovulation will therefore occur around day 14, leaving a 2-week time frame to the lead up of your next period. From my experience in clinic, this textbook 28-day cycle with ovulation occurring on day 14, is not the norm for many women. A delay in ovulation can often occur, which creates a lengthier follicular phase (explained below) resulting in a longer cycle. Otherwise a shorter follicular phase may occur creating a shorter time from your period to ovulation, or a shorter luteal phase may take place (ovulation to your period). The latter of the two is a common cause of an infertile cycle, referred to as a luteal phase defect which I’ll explain in chapter 3. 7 The Follicular Phase The first half of your cycle, from menstruation up to ovulation is known as the follicular phase and is responsible for your egg development. During the follicular phase, your cervix is blocked by a thick mucous plug which protects your reproductive system from infection and also prevents conception, by blocking the entrance of sperm. At some stage in the follicular phase (this differs for every woman), the follicle stimulating hormone (FSH) stimulates small amounts of oestrogen and progesterone to be produced from your ovaries and sent throughout your bloodstream. The oestrogen triggers several clusters of cells (called follicles) to begin ripening. Each of these follicles contains a precious egg. As the follicles grow, they manufacture and further release oestrogen (oestradiol) into your blood stream. During the follicular phase, oestrogen levels build up to a peak, just before ovulation. This heightened level of oestrogen stimulates the production of a fertile, wet, sperm-protective mucous from your cervix which is usually very detectible for you to feel and see. Before this occurs, some women experience the mucous plug being released from the cervix and vagina which often appears as a thick blob of glue like substance and allows the fertile mucous through. These mucous changes are an important sign that your body is preparing for ovulation and therefore should be considered a time of potential fertility. Ovulation Ovulation is the magical time when the fully matured follicle has made its way to the surface of the ovary and ejects an egg into the abdominal cavity. For ovulation to occur, your pituitary gland must release a surge of luteinising hormone (LH) that therefore triggers your ovaries to promote this fully matured follicle. LH also stimulates the ovaries to produce increased levels of the sex hormone progesterone. If ovulation was to happen on day 14, this progesterone surge occurs around day 12-13 of your cycle. 8 Along with supporting the development of the tissue and blood in your uterus, progesterone encourages the change to a slippery sensation of egg-white type mucous at the cervix, a rise in body temperature and an increased libido, which you may experience at the time of ovulation. The mucous changes around ovulation (egg white type) occur as the rise in progesterone triggers the production of mineral manganese at the small folds in the lower end of the vagina (known as pockets of shaw). Interestingly, progesterone also initiates communication from the matured egg producing ovary to the other ovary, to stop the growth of their follicles. This allows the chosen matured follicle to continue rapid growth (up to ¾ inch in size), in the last 1-2 days before ovulation. Once the egg is released at ovulation, the follicle transforms into an endocrine gland, known as the corpus luteum and resembles a blister on the surface of your ovary. Oestrogen production continues from the corpus luteum but progesterone should be dominant in this second half of your cycle called the Luteal Phase. As Dr Sherrill Sellman explains in her book Hormone Heresy: What Women Must Know About Their Hormones, “When Progesterone peaks (in the luteal phase), there is about 200 times as much progesterone as oestrogen.” pg. 35, 1 Progesterone also plays an important role in balancing your moods, by stimulating the activity of the calming neurotransmitter called gamma-Aminobutyric acid, or better known as GABA. Progesterone is the precursor for a neuro-steroid in the brain called allopregnanolone. This neuro-steroid binds to a GABA receptor, stimulating GABA activity which results in helping to alleviate your pain, anxiety and irritability.2 9 The Luteal Phase The luteal phase of a cycle can vary from woman to woman but is generally the same time frame during each of your cycles. This can vary from 11-16 days, but must be at least 11 days for the cycle to be considered fertile. A short luteal phase indicates an issue at ovulation leading to inadequate progesterone production or an early drop in progesterone levels. As progesterone is the hormone required to ripen and preserve the tissue and blood of your uterus, a deficiency causes premature shedding of the uterus lining and results in an infertile cycle called a luteal phase defect. Apart from early menstruation, other symptoms of a luteal phase defect may include an erratic basal body temperature after ovulation, lower back pain and loose stools. The resulting luteal phase defect is also a major contributor of repeated miscarriages. On testing, progesterone levels will be deficient for where they should be in a healthy luteal phase. See more information about recommended testing in chapter 4. A luteal phase defect can occur during any cycle, due to different factors. If the pituitary gland doesn’t produce enough FSH in the first half of your cycle, this will contribute to weakened follicle production, low oestrogen levels, a thin uterine lining and therefore early menstruation. In the case of fertility, this state will cause challenges with fertilisation and healthy implantation. The absence of a LH surge required to bring on ovulation, can also cause a luteal phase defect. This is a common occurrence in the condition of polycystic ovarian syndrome (PCOS). Learn more about contributors to low FSH, LH, oestrogen and progesterone production, in chapter 3. 10 Successful ovulation & fertilisation After ovulation, the egg is gracefully scooped up by the finger like fibrae of the fallopian tube and encouraged along by contraction-like movements and the brushing motion of microscopic hairs along the fallopian tube lining. The egg has a lifespan of 12-24 hours, unless fertilised by a sperm within this time. It is here in the outer third of the fallopian tube where an egg may become fertilised with a sperm, forming a single celled zygote. If fertilisation occurs, the zygote is the earliest form of an embryo and contains ‘the plan’ for the whole body. In a swimming motion, the zygote heads towards the uterus and prepares the body for its arrival. This zygote continues along the fallopian tube and toward the uterus, where the final maturation occurs. It begins dividing at a fast rate and creates a cluster of cells approximately the size of a raspberry. After the first division, the development of the embryo begins and is referred to as a morula. By day 5 after fertilisation, the embryo develops into an early blastocyst. Throughout this time, progesterone plays an important role in supporting the uterine lining to build strength and resilience. It becomes thickened and engorged with blood in preparation to support a growing foetus. Progesterone deficiency during this time of the cycle can therefore contribute to issues with conception and miscarriage. Pregnancy Once the blastocyst reaches the womb, implantation into the uterus wall begins at around day 8-9 and finishes around day 14, after fertilisation has taken place. Successful implantation triggers the release of the human chorionic gonoadotropin hormone (better known as hCG) to prepare the womb to nourish the developing embryo. The hCG released also reaches the ovaries to prevent another ovulation to take place. When implantation is effective, pregnancy occurs and the production of progesterone continues, preventing the lining of the uterus to shed and therefore sustains the developing embryo. Production of progesterone through pregnancy is taken over by the placenta; the organ which nourishes the foetus through the umbilical cord. Throughout pregnancy, levels 11 of oestrogen also soar to around one thousand times that of a non-pregnant state, driving the size and development of the uterus, as well as the breasts in preparation for lactation. Fig. 3: Ovulation, Fertilisation & Implantation When fertilisation is unsuccessful If the egg is not fertilised in the fallopian tube within 24 hours, it will die and disintegrate. If a fertilised egg is not implanted into the lining of the uterus, the body will reabsorb it. In both cases the levels of oestrogen and progesterone drop off and from 11-16 days following ovulation your uterus sheds it’s lining, making up the blood of your menstruation. 12 The Period The bleeding of menstruation typically lasts 4-5 days but also varies from cycle to cycle and woman to woman. This process should be virtually pain free and should not cause the need to be housebound, due to heaviness (although I often hear reports of otherwise). As the follicular phase kicks off, more hormones are released, new growth occurs and the cycle continues. Fig. 4: Hormone levels and uterine lining throughout the menstrual cycle 13 Breastfeeding At birth, your placenta is expelled, resulting in drastically reduced progesterone production and activates your breast milk. Just seeing, smelling and thinking about your baby, together with the suckling during breastfeeding will stimulate the hormone prolactin and oxytocin to be produced from your pituitary gland. These hormones in turn initiate the production and release of your milk supply. Providing that breastfeeding is regular, cycles are generally non-existent during the first 6 months of breast feeding, due to the reduction of oestrogen during this time. As oestrogen is required to ovulate, ovulation is also put on hold. Past the 6-month mark of breastfeeding, or as your feeds are fewer and farther between, oestrogen levels start to rise and ovulation can occur. Despite the old wives’ tale, it is therefore still very likely to fall pregnant while breastfeeding. Menopause At around the age of 40 (in some cases much earlier or later), a woman enters the stage of peri menopause. It is still unknown if this is initially triggered by the hypothalamus and pituitary gland in the brain, or the ovaries. As follicle stimulation drops off, your production of oestrogen and progesterone from your ovaries will also reduce by around 40-60% at the time of menopause. Periods become irregular, light and eventually cease completely. Menopause is embraced once you are without a menstrual cycle for 12 consecutive months. The ovaries continue to produce small amounts of sex hormones, along with the adrenal glands, which work in unity to support bone and skin health, libido and protect against heart disease. 14 The Thyroid & Adrenal Gland Dance Your Thyroid Gland Function Your thyroid gland is a crucial part of your body’s endocrine system and is found in prime position, at the front of your neck. Just like your menstrual cycle, thyroid function is also a brain driven event via a feedback loop between your hypothalamus, pituitary and thyroid gland. The balance of your adrenal and sex hormones are also reliant on the health of your thyroid. In order to have balanced thyroid function and adequate thyroid hormone levels to use throughout your body, a cascade of reactions must occur. 1.As needed, the hypothalamus gland in your brain sends out thyrotropin releasing hormone (TRH), to stimulate your pituitary gland into releasing thyroid stimulating hormone (TSH). 2.TSH triggers the production and release of thyroid hormones, thyroxine (T4) and triiodothyronine (T3), which are used for numerous functions in the body. Amongst these are improved oxygen uptake by your cells, energy production, healthy development and maintenance of your metabolic rate and body temperature. 3.T4 is the inactive form of thyroid hormone, and requires effective conversion into T3, for your body to utilise it for important intracellular functions. Once converted, T3 binds to available thyroid receptors and energises all the cells of your body. When your body is under stress, in a state of toxic overload and/ or nutritional deficiency, conversion into T3 can be restricted. Instead, the body will convert T4, into a dangerous inactive form of T3, called reverse T3 (RT3). Healthy thyroid function therefore relies on controlled conversion of T3 into RT3. 4.Stress, heightened inflammation and/ or immune dysregulation, may cause your body to detect normal healthy thyroid tissue, as foreign. When this 15 occurs, thyroid antibodies are produced, including thyroid peroxidase (TPO) and thyroglobulin (TG) antibodies. Increased thyroid antibodies occur in the auto immune conditions of the thyroid, such as hashimotos thyroiditis and graves disease. Another facet of having a healthy, balanced thyroid gland is therefore controlled antibody production. Have you been misdiagnosed? Far too often I see patients who have been told by their GP that their thyroid gland function is healthy. Unfortunately, the whole panel of thyroid hormones and thyroid antibodies are missed. This was the case for Tamara. Tamara presented to me with symptoms of extreme fatigue, poor concentration levels, thinning hair and all over body aches. She suffered with ongoing painful periods and was starting to notice an increase in midsection weight. Although her symptoms seemed like an obvious case of underactive thyroid, I ran some bloods to rule out autoimmune activity. Although Tamara’s TSH result was within range, she showed an extremely high level of thyroid antibodies, along with low T4 and T3 hormones. If the TSH had merely been tested, her results would have looked normal. As I looked into the whole thyroid panel, the underlying driver of her underactive thyroid was detected. We could then focus on detecting the causes of her heightened antibodies and work on regaining normal thyroid hormone production and reversal of her symptoms. If I hadn’t requested the extra test to check for T4 and T3 hormones, plus thyroid antibodies, Tamara would have been told by her GP that her thyroid function was healthy. With any unresolved symptoms pointing to an underactive thyroid, or other adrenal and sex hormone symptoms, it is always important to check the whole panel of TSH, T4, T3, RT3 and rule out auto-immunity of your thyroid. See chapter 4 for more information on thyroid testing. 16 Nutrients needed for healthy thyroid function The production of thyroid hormone takes place in the follicles of your thyroid, which requires the mineral iodine and the amino acid, tyrosine.3,4 Inositol (part of the B group vitamin family), sensitises the response of the body to TSH, to initiate the first steps of thyroid hormone production. Adequate levels of the minerals iodine 5, selenium and zinc, together with the amino acid tyrosine,pg. 143, 6 are required for the body to produce healthy levels of thyroid hormones T3 and T4. Vitamin A, C, D and E also contribute to healthy thyroid hormone production via their antioxidant support. Additionally, vitamin A supports the formation of thyroid hormone receptors. Indirectly, tyrosine and Vitamin B5 improve thyroid health, by supporting adrenal gland function, while B6 encourages balanced neurotransmitter levels in your brain. T4 contains 4 molecules of the mineral iodine and T3 contains 3 iodine molecules, therefore without adequate iodine levels in your body, the health of your thyroid and production of thyroid hormones, will suffer.pg. 141, 7 The mineral selenium is just as important as the critical conversion of T4 into T3 involves a process which removes one iodine molecule of T4 (called monodeiodination) and relies on 3 selenium dependant enzymes (called deiodinases).pg. 161, 8 The majority of this vital conversion of T4 into T3 takes place in your liver, therefore the health of your liver is also essential for thyroid health.9, 10 Once converted, B group vitamins and the mineral iron, play an important role in encouraging the production of energy (ATP) from T3, while vitamin A and zinc improve cellular sensitivity toward thyroid hormone. Healthy digestion and adequate levels of the minerals zinc and selenium, along with B2 and B6, promote healthy immune function, providing auto-immune prevention. Your Adrenal Gland Health The tongue twisting hypothalamic-pituitary-adrenal axis, also known as the HPAAxis, refers to the communication between your hypothalamus and pituitary 17 glands in your brain, with your adrenal glands. It’s the crucial feedback between these glands which helps to control your stress response in your body, amongst managing your energy levels, digestion, immunity, moods, emotions, memory and metabolism. How your adrenal glands affect your hormone health Your two walnut sized adrenal glands sit just above your kidneys and contain two sections, the inner adrenal medulla and the outer adrenal cortex. The adrenals are stimulated via the HPA-Axis and responsible for the production of hormones and chemicals, which in turn regulate your moods, thyroid and sex hormone health. Your adrenal glands control the release of: • Adrenaline (epinephrine) and noradrenaline (norepinephrine) are produced by the adrenal medulla and released into your bloodstream as your short-term stress hormones. Adrenaline would be released if someone jumped out from behind the door to scare you and consequently affect your autonomic nervous system (ANS), to escape the danger. It triggers the release of glucose into your blood stream, increases blood pressure, mental alertness and respiratory rate. You may also notice increased sweating and the need to urinate more often. Blood supply is also directed away from your digestive system to your arms and legs, to allow for a swift escape. • Dopamine is produced from the adrenals in small amounts, also in response to stress. It is actually the precursor to adrenaline and noradrenaline and responsible for experiencing feelings of pleasure and euphoria. • Cortisol and to a lesser extent, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEA-S), are also produced and released from your adrenal glands when the HPA-Axis is stimulated under a perceived physical, chemical or psychological stress. The hypothalamus gland in your brain triggers your pituitary gland via the corticotropinreleasing hormone (CRH), to produce a hormone messenger called adrenocorticotrophic hormone (ACTH). 18 ACTH stimulates the adrenal cortex to produce the stress hormones cortisol, DHEA and DHEA-S. Once the stress is over, feedback is sent back to your brain, to slow the production of CRH and ACTH and therefore normalise cortisol synthesis. All sex hormones are derived initially from cholesterol which is your hormone building block. This cholesterol is converted into your mother hormone pregnenolone and feeds your DHEA production. DHEA is converted into androstenedione, which fuels the production of testosterone and potentially (if the conditions in the body favour the pathway), to the more potent and dangerous form of testosterone, dihydriotestosterone (DHT). Although the exact level is unknown, oestrogen and progesterone are also produced from the adrenal cortex in premenopausal years. After this time, your adrenals take over from the ovaries with the majority of your sex hormone production. • Aldosterone is produced from the outer adrenal cortex of your adrenal glands, to control your body’s water and salt balance and therefore blood pressure. These hormones and chemicals enter your blood stream and act as messengers to the tissues of your body to control certain functions. Cortisol Other than the production of cortisol from your adrenal glands in response to stress, levels are naturally released at higher amounts via your HPA-Axis, in the morning. Cortisol should peak 30-60 minutes after waking to support your energy levels, but production should gradually decrease over the day, to eventual low levels at night. This enables the sleep hormone melatonin to kick in and promote a restful night’s sleep. At healthy levels, cortisol provides an important anti-inflammatory role in your body and helps to control your pain levels. 19 Fig. 5: The HPA Axis Stress Response Your addictive screen time, 3pm caffeine hit or extensive late night workout, might be disrupting your body’s natural cortisol rhythm. More on the contributors to adrenal gland stress next up in chapter 3. 20 Blood Sugar, Insulin & Leptin Level Balance How food can affect your hormones The food and drinks you consume and how your body uses them, will ultimately effect your hormone balance. Keeping it simple, when meals and beverages containing carbohydrates (mainly fruits, vegetables, grains, legumes, sweets and any products made from them) are ingested, they are broken down by digestive enzymes and good bacteria, into three primary building blocks being glucose, fructose and ribose. Differing amounts are found in each food and food item. Glucose Any glucose from these foods moves directly from your small intestine and into your bloodstream. The rate at which glucose causes a spike in blood sugar (glucose) levels, depends on the foods glycemic index (GI). The increase in glucose stimulates your pancreas to release the hormone insulin. Insulin is responsible for transporting glucose into the cells of your tissues and organs, where it is used for energy or stored as fat, in times of inactivity. It is crucial for your body to therefore be sensitive towards this insulin, to ensure healthy blood sugar levels, weight, cardiovascular, brain and hormonal health, among much more. Fructose & Insulin Fructose, also known as fruit sugar, is metabolised differently. When fructose is consumed, it must be transported from your small intestine into the liver, to be metabolised. Where the body can use glucose as fuel, it stores fructose in the liver. When fructose reaches your liver, it is converted into triglycerides (fat) and transported around the body for storage. Insulin levels also soar when fructose is delivered to the liver and overtime, contributes to a condition of insulin resistance. Fructose rich foods are mistaken as a healthier option because the fructose doesn’t raise the blood sugar levels as rapidly as glucose and therefore has a lower GI. Later in chapter 3 I’ll discuss why fructose can be extremely damaging to 21 your body, when consumed in high levels. Leptin The hormone leptin works hand in hand with insulin, and plays a crucial role in your appetite control, the quality and rate of your metabolism, hormone health and longevity. It is produced by your fat cells which signals to the brain when you are in need of or have an excess of energy and what to do with it. Leptin tells your brain when you should be hungry, store fat, burn fat, or allow the body to rest and repair. When leptin is activated and your body is responding to the levels, you are able to appropriately regulate your hunger. Fig. 6: The healthy leptin response It’s a rare case when I see a patient who is presenting with optimal endocrine gland control and function. Through my clinical experience, hormone health is an area requiring constant, attention, support and nourishment. 22 Are your hormones working in harmony or causing havoc? Find out if your hormones are imbalanced and affecting the way you look and feel, by reading my hormone health book- Balanced, The Natural Way To Healthy Hormones. I delve into common hormone imbalance signs, symptoms and share effective diet, lifestyle and supplementation treatment to promote a state of hormone balance in your body. Find out more here: www.kaseywillsonnd.com/balanced/ I look forward to guiding you to healthy hormones. References (1) Sellman, S. Hormone Heresy, What Woman Must Know About Their Hormones. Australia: Joshua Books; 2011. (2) Schule C, Nothdurfter C, Rupprecht R. The role of allopregnanolone in depression and anxiety. Prog Neurobiol. 2014 Feb;133:79-87. (3) Tortora, Grabowski. Principles of anatomy and physiology, 7th ed. Harper Collins, 1993. (4) Guyton AC, Hall JE. Textbook of Medical Physiology, 11th ed. Philadelphia: Elsevier, 2006. (5) Natural Medicines. Iodine. Viewed Jan 2016, https://naturalmedicines.therapeuticresearch. com/databases/food,-herbs-supplements/professional.aspx?productid=35. (6) Osiecki H. The Nutrient Bibl. 8 th edition. QLD Australia: Bio Concepts Publishing. (7) Osiecki H. The Nutrient Bibl. 8 th edition. QLD Australia: Bio Concepts Publishing. (8) Osiecki H. The Nutrient Bibl. 8 th edition. QLD Australia: Bio Concepts Publishing. (9) Roti E, Minelli R, Salvi M. Thyroid hormone metabolism in obesity. Int J Obes Relat Metab Disord 2000;24 Supp 2:S113-S115. (10) Kelly GS. Peripheral metabolism of thyroid hormones: a review. Altern Med Rev 2000;5(4):306333. 23
© Copyright 2026 Paperzz